aspirin has been researched along with Femur Neck Fractures in 18 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A prospective, randomized controlled trial was used to compare the efficacy of the arteriovenous (AV) impulse system and aspirin in reducing venous thrombosis after fracture to the femoral neck." | 9.09 | Deep vein thrombosis prophylaxis in hip fractures: a comparison of the arteriovenous impulse system and aspirin. ( Dallo Vedova, PA; Griffen, DR; Kennedy, JG; Kumar, S; Rogers, BW; Sheehan, LJ; Soffe, KE; Sullivan, RJ, 2000) |
| "Among the patients with hip fracture, allocation to aspirin produced proportional reductions in pulmonary embolism of 43% (95% CI 18-60; p=0." | 9.09 | Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial. ( , 2000) |
| "A prospective, randomized controlled trial was used to compare the efficacy of the arteriovenous (AV) impulse system and aspirin in reducing venous thrombosis after fracture to the femoral neck." | 5.09 | Deep vein thrombosis prophylaxis in hip fractures: a comparison of the arteriovenous impulse system and aspirin. ( Dallo Vedova, PA; Griffen, DR; Kennedy, JG; Kumar, S; Rogers, BW; Sheehan, LJ; Soffe, KE; Sullivan, RJ, 2000) |
| "Among the patients with hip fracture, allocation to aspirin produced proportional reductions in pulmonary embolism of 43% (95% CI 18-60; p=0." | 5.09 | Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial. ( , 2000) |
| "A telephone questionnaire was undertaken to examine the current practice amongst 110 orthopaedic departments in the UK regarding the discontinuation of clopidogrel prior to trauma surgery for femoral neck fractures." | 3.74 | Is clopidogrel stopped prior to hip fracture surgery--A survey of current practice in the United Kingdom. ( Odutola, A; Palan, J; White, SP, 2007) |
| " It appears from this study that in these cases prophylaxis against venous thromboembolism using aspirin in a dosage of 600 mg bid is ineffective." | 1.26 | Aspirin prophylaxis of venous thromboembolic disease following fracture of the upper femur. ( Channon, GM; Wiley, AM, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (38.89) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ginsel, BL | 1 |
| Taher, A | 1 |
| Whitehouse, SL | 1 |
| Bell, JJ | 1 |
| Pulle, CR | 1 |
| Crawford, RW | 1 |
| Li, T | 1 |
| Lv, M | 1 |
| Li, Q | 1 |
| Duggie, AJ | 1 |
| Dimech, J | 1 |
| Manning, BJ | 1 |
| O'Brien, N | 1 |
| Aravindan, S | 1 |
| Cahill, RA | 1 |
| McGreal, G | 1 |
| Redmond, HP | 1 |
| Hitos, K | 1 |
| Fletcher, JP | 1 |
| Palan, J | 1 |
| Odutola, A | 1 |
| White, SP | 1 |
| Rodgers, A | 1 |
| Gray, H | 1 |
| MacMahon, S | 1 |
| Spansberg, NL | 1 |
| Anker-Møller, E | 1 |
| Dahl, JB | 1 |
| Schultz, P | 1 |
| Christensen, EF | 1 |
| Prentice, CR | 2 |
| Kennedy, JG | 1 |
| Soffe, KE | 1 |
| Rogers, BW | 1 |
| Kumar, S | 1 |
| Griffen, DR | 1 |
| Dallo Vedova, PA | 1 |
| Sullivan, RJ | 1 |
| Sheehan, LJ | 1 |
| Wiggins, CE | 1 |
| Channon, GM | 1 |
| Wiley, AM | 1 |
| Morris, GK | 1 |
| Mitchell, JR | 1 |
| Mazuch, J | 1 |
| Mihalovics, T | 1 |
| Filo, M | 1 |
| Zekert, F | 1 |
| Kohn, P | 1 |
| Vormittag, E | 1 |
| Poigenfürst, J | 1 |
| Thien, M | 1 |
| Lyon, LJ | 1 |
| Nevins, MA | 1 |
| Wood, EH | 1 |
| McGrouther, DA | 1 |
| Sinclair, J | 1 |
| McNicol, GP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Nonrandomized, Study Comparing the Use of Aspirin and Intraoperative Blood Loss and Postoperative Complications Following Open Inguinal Hernia Repair.[NCT02084615] | 300 participants (Anticipated) | Interventional | 2014-08-31 | Enrolling by invitation | |||
| A Different Approach to Preventing Thrombosis (ADAPT): A Randomized Controlled Trial Comparing Low Molecular Weight Heparin to Acetylsalicylic Acid in Orthopedic Trauma Patients[NCT02774265] | Phase 3 | 329 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
DVT and how the diagnosis was made will be recorded. The number of events in participants in each arm will be compared to evaluate efficacy. (NCT02774265)
Timeframe: 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| VTE Prophylaxis With Enoxaparin 30mg BID | 5 |
| VTE Prophylaxis With Aspirin 81mg BID | 9 |
Bases on imaging obtained for symptoms. (NCT02774265)
Timeframe: 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| VTE Prophylaxis With Enoxaparin 30mg BID | 6 |
| VTE Prophylaxis With Aspirin 81mg BID | 2 |
Includes a greater than 2g/dL drop in hemoglobin, blood transfusion, hematoma evacuation, re-operation for a deep surgical site infection or minor procedure for bleeding and GI bleed (NCT02774265)
Timeframe: 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| VTE Prophylaxis With Enoxaparin 30mg BID | 52 |
| VTE Prophylaxis With Aspirin 81mg BID | 53 |
1 review available for aspirin and Femur Neck Fractures
| Article | Year |
|---|---|
Prevention of thromboembolism after hip fracture.
Topics: Aged; Anticoagulants; Aspirin; Bandages; Coumarins; Dextrans; Exercise Therapy; Femoral Neck Fractur | 1973 |
7 trials available for aspirin and Femur Neck Fractures
| Article | Year |
|---|---|
[Comprehensive prophylaxis for deep venous thrombosis after proximal femur fractures in geriatric patients].
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Combined Modality Therapy; Female; Femoral Neck Fr | 2008 |
The value of continuous blockade of the lumbar plexus as an adjunct to acetylsalicyclic acid for pain relief after surgery for femoral neck fractures.
Topics: Administration, Rectal; Aged; Aged, 80 and over; Analgesia; Analgesics, Opioid; Anesthesia, Spinal; | 1996 |
Deep vein thrombosis prophylaxis in hip fractures: a comparison of the arteriovenous impulse system and aspirin.
Topics: Aged; Aspirin; Cardiology; Female; Femoral Neck Fractures; Humans; Leg; Male; Platelet Aggregation I | 2000 |
Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial.
Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Aspirin; Cause of Death; Dose-Response Rela | 2000 |
Preventing venous thromboembolism in elderly patients with hip fractures: studies of low-dose heparin, dipyridamole, aspirin, and flurbiprofen.
Topics: Age Factors; Aged; Aspirin; Dipyridamole; Drug Evaluation; Femoral Neck Fractures; Flurbiprofen; Hep | 1977 |
[Prevention of thromboembolism using acetylsalicylic acid in the surgery of hip-joint proximal fractures].
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Female; Femoral Fractures; Femoral Neck Fractures; H | 1974 |
Trial of aspirin and RA 233 in prevention of post-operative deep vein thrombosis.
Topics: Aspirin; Dipyridamole; Femoral Neck Fractures; Fibrinogen; Humans; Iodine Radioisotopes; Placebos; P | 1973 |
10 other studies available for aspirin and Femur Neck Fractures
| Article | Year |
|---|---|
Effects of anticoagulants on outcome of femoral neck fracture surgery.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Female; Femoral Neck Fractures; Human | 2015 |
Emergency surgery following trancutaneous aortic valve insertion.
Topics: Aged, 80 and over; Aortic Valve; Aspirin; Blood Loss, Surgical; Clopidogrel; Emergency Medical Servi | 2011 |
The effect of aspirin on blood loss and transfusion requirements in patients with femoral neck fractures.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Loss, Surgical; Blo | 2004 |
Venous thromboembolism and fractured neck of femur.
Topics: Aged; Aged, 80 and over; Anesthesia; Anticoagulants; Aspirin; Blood Loss, Surgical; Blood Transfusio | 2005 |
Is clopidogrel stopped prior to hip fracture surgery--A survey of current practice in the United Kingdom.
Topics: Anticoagulants; Aspirin; Clinical Protocols; Clopidogrel; Contraindications; Femoral Neck Fractures; | 2007 |
Pharmacological thromboprophylaxis in hip and knee surgery: a survey of New Zealand orthopaedic surgeons.
Topics: Arthroplasty; Aspirin; Femoral Neck Fractures; Heparin; Heparin, Low-Molecular-Weight; Hip Joint; Hu | 1994 |
Thromboprophylaxis in elective orthopaedic surgery -- what is the purpose?
Topics: Anticoagulants; Aspirin; Bone and Bones; Chemoprevention; Elective Surgical Procedures; Femoral Neck | 1997 |
Pulmonary embolism prophylaxis in the orthopaedic and trauma patient.
Topics: Arthroplasty; Aspirin; Dextrans; Femoral Neck Fractures; Heparin; Hip Joint; Humans; Postoperative C | 1976 |
Aspirin prophylaxis of venous thromboembolic disease following fracture of the upper femur.
Topics: Aged; Aspirin; Female; Femoral Neck Fractures; Hip Fractures; Hip Prosthesis; Humans; Male; Middle A | 1979 |
[Prevention of thromboembolic complications in fractures of the upper part of the femur].
Topics: Aged; Aspirin; Femoral Neck Fractures; Fracture Fixation, Internal; Heparin; Humans; Middle Aged; Po | 1986 |