Page last updated: 2024-10-23

aspirin and Fatty Liver

aspirin has been researched along with Fatty Liver in 20 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.

Research Excerpts

ExcerptRelevanceReference
"Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury; however its therapeutic strategy has not been established yet."5.37Nitro-aspirin is a potential therapy for non alcoholic fatty liver disease. ( Abdelrahman, AM; Farghaly, E; Gomaa, W; Ibrahim, M; Kelleni, M, 2011)
"Acute fatty liver is a rare but fatal complication of pregnancy."5.32Acute fatty liver of pregnancy after aspirin intake. ( Deren, O; Durukan, T; Kizilkiliç-Parlakgümüş, A; Onderoğlu, L; Saygan-Karamürsel, B, 2004)
"This cohort study demonstrated that regular aspirin use was associated with a reduced risk of liver disease in men without an elevated risk of gastrointestinal bleeding or ulcers."4.31Aspirin is associated with a reduced incidence of liver disease in men. ( Alqahtani, S; Creasy, KT; Hehl, L; Krishnan, A; Rader, DJ; Rendel, MD; Schneider, CV; Schneider, KM; Scorletti, E; Seeling, KS; Serper, M; Trautwein, C; Vell, MS; Vujkovic, M; Wangensteen, K; Zandvakili, I, 2023)
"All three antiplatelet drugs, namely aspirin, ticlopidine and cilostazol, significantly attenuated liver steatosis, inflammation and fibrosis in the CDAA diet group."3.74Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease. ( Abe, Y; Endo, H; Fujita, K; Inamori, M; Iwasaki, T; Kirikoshi, H; Kobayashi, N; Kubota, K; Nagashima, Y; Nakajima, A; Nozaki, Y; Saito, S; Takahashi, H; Wada, K; Yoneda, M, 2008)
"Effects of inhibitors of arachidonic acid (AA) metabolism on the development of fatty liver, cirrhosis, glutathione-S-transferase placental form (GST-P)-positive nodules and the generation of 8-hydroxydeoxyguanosine (8-OHdG) and thiobarbituric acid-reactive substances (TBARS), caused by a choline-deficient, L-amino acid-defined (CDAA) diet, were examined in male Fischer 344 rats by feeding CDAA diets supplemented with the inhibitors for 12 and 30 weeks."3.69Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats. ( Denda, A; Endoh, T; Horiguchi, K; Kobayashi, E; Konishi, Y; Nakae, D; Noguchi, O; Ogasawara, H; Sugimura, M; Tamura, K; Tang, Q; Tsujiuchi, T, 1996)
"Gallbladder stones (cholecystolithiasis) are the main risk factor for gallbladder cancer (GBC), a lethal biliary malignancy with poor survival rates worldwide."1.56Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia. ( Arrese, M; Bizama, C; Espinoza, JA; Ferreccio, C; García, P; Gómez, N; González, X; Guevara, F; Kalergis, AM; Lobos-González, L; Miquel, JF; Muñoz-Durango, N; Roa, JC; Rosa, L; Saavedra, N; Villegas, J; Wichmann, IA, 2020)
"Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury; however its therapeutic strategy has not been established yet."1.37Nitro-aspirin is a potential therapy for non alcoholic fatty liver disease. ( Abdelrahman, AM; Farghaly, E; Gomaa, W; Ibrahim, M; Kelleni, M, 2011)
"Aspirin intake was associated with reduced risk for sinusoidal lesions (P = ."1.35Risk factors for chemotherapy-associated liver injuries: A multivariate analysis of a group of 146 patients with colorectal metastases. ( Beauchet, A; Benoist, S; Brouquet, A; Julie, C; Nordlinger, B; Penna, C; Rougier, P, 2009)
"Acute fatty liver is a rare but fatal complication of pregnancy."1.32Acute fatty liver of pregnancy after aspirin intake. ( Deren, O; Durukan, T; Kizilkiliç-Parlakgümüş, A; Onderoğlu, L; Saygan-Karamürsel, B, 2004)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19909 (45.00)18.7374
1990's2 (10.00)18.2507
2000's4 (20.00)29.6817
2010's2 (10.00)24.3611
2020's3 (15.00)2.80

Authors

AuthorsStudies
Vell, MS1
Krishnan, A1
Wangensteen, K1
Serper, M1
Seeling, KS1
Hehl, L1
Rendel, MD1
Zandvakili, I1
Vujkovic, M1
Scorletti, E1
Creasy, KT1
Trautwein, C1
Rader, DJ1
Alqahtani, S1
Schneider, KM1
Schneider, CV1
Rosa, L1
Lobos-González, L1
Muñoz-Durango, N1
García, P1
Bizama, C1
Gómez, N1
González, X1
Wichmann, IA1
Saavedra, N1
Guevara, F1
Villegas, J1
Arrese, M1
Ferreccio, C1
Kalergis, AM1
Miquel, JF1
Espinoza, JA1
Roa, JC1
Kinter, CW1
Saxon, GE1
Ahmad, M1
Berhane, H1
Gensler, L1
Khosroshahi, A1
Fujita, K1
Nozaki, Y1
Wada, K1
Yoneda, M1
Endo, H1
Takahashi, H1
Iwasaki, T1
Inamori, M1
Abe, Y1
Kobayashi, N1
Kirikoshi, H1
Kubota, K1
Saito, S1
Nagashima, Y1
Nakajima, A1
Brouquet, A1
Benoist, S1
Julie, C1
Penna, C1
Beauchet, A1
Rougier, P1
Nordlinger, B1
Ibrahim, M1
Farghaly, E1
Gomaa, W1
Kelleni, M1
Abdelrahman, AM1
Russo, MW1
Pierson, J1
Narang, T1
Montegudo, A1
Eskind, L1
Gulati, S1
GILES, HM1
Saygan-Karamürsel, B1
Kizilkiliç-Parlakgümüş, A1
Deren, O1
Onderoğlu, L1
Durukan, T1
Farhadi, A1
Gundlapalli, S1
Shaikh, M1
Frantzides, C1
Harrell, L1
Kwasny, MM1
Keshavarzian, A1
Kolts, BE1
Langfitt, M1
Fraser, JL1
Antonioli, DA1
Chopra, S1
Wang, HH1
Endoh, T1
Tang, Q1
Denda, A1
Noguchi, O1
Kobayashi, E1
Tamura, K1
Horiguchi, K1
Ogasawara, H1
Tsujiuchi, T1
Nakae, D1
Sugimura, M1
Konishi, Y1
Linnemann, CC1
Ueda, K1
Hug, G1
Schaeffer, A1
Clark, A1
Schiff, GM1
Thaler, MM1
Velásquez-Jones, L1
Simell, O1
Hilty, MD1
Romshe, CA1
Delamater, PV1
Strauss, RG1
McAdams, AJ1

Reviews

1 review available for aspirin and Fatty Liver

ArticleYear
Metabolic mechanisms in Reye syndrome. End of a Mystery?
    American journal of diseases of children (1960), 1976, Volume: 130, Issue:3

    Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Aspirin; Brain Diseases; Carbamoyl-Phosphate Synthase

1976

Other Studies

19 other studies available for aspirin and Fatty Liver

ArticleYear
Aspirin is associated with a reduced incidence of liver disease in men.
    Hepatology communications, 2023, 10-01, Volume: 7, Issue:10

    Topics: Aspirin; Cohort Studies; Fatty Liver; Female; Gastrointestinal Hemorrhage; Humans; Incidence; Liver

2023
Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia.
    Molecular oncology, 2020, Volume: 14, Issue:11

    Topics: Animals; Aspirin; Chemoprevention; Cholecystolithiasis; Cholesterol; Cholesterol, Dietary; Chronic D

2020
Multisystem inflammatory syndrome in an adult with involvement of the skin, lymph nodes, muscle, heart, liver and kidneys.
    Rheumatology (Oxford, England), 2021, 11-03, Volume: 60, Issue:11

    Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents; Aspirin; Asymptomatic Infections; Biomarkers;

2021
Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease.
    Gut, 2008, Volume: 57, Issue:11

    Topics: Alanine Transaminase; Animals; Aspirin; Cholesterol; Choline Deficiency; Cilostazol; Dietary Fats; D

2008
Risk factors for chemotherapy-associated liver injuries: A multivariate analysis of a group of 146 patients with colorectal metastases.
    Surgery, 2009, Volume: 145, Issue:4

    Topics: Aged; Antineoplastic Agents; Aspirin; Chemical and Drug Induced Liver Injury; Colorectal Neoplasms;

2009
Nitro-aspirin is a potential therapy for non alcoholic fatty liver disease.
    European journal of pharmacology, 2011, Jun-01, Volume: 659, Issue:2-3

    Topics: Alanine Transaminase; Animals; Aspirin; Cyclooxygenase 2; Fatty Liver; Gene Expression Regulation, E

2011
Coronary artery stents and antiplatelet therapy in patients with cirrhosis.
    Journal of clinical gastroenterology, 2012, Volume: 46, Issue:4

    Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Fatty Liver; Female; Follow-Up Studies; Gastroi

2012
ENCEPHALOPATHY AND FATTY DEGENERATION OF THE VISCERA.
    Lancet (London, England), 1965, May-15, Volume: 1, Issue:7394

    Topics: Aspirin; Brain Diseases; Carbohydrate Metabolism; Coma; Fatty Liver; Heart Diseases; Humans; Kidney

1965
Acute fatty liver of pregnancy after aspirin intake.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2004, Volume: 16, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Component Transfusion; Diagnosis, Dif

2004
Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis.
    Liver international : official journal of the International Association for the Study of the Liver, 2008, Volume: 28, Issue:7

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Endotoxemia; Fatty Liver; Female; Humans; I

2008
Drugs and the liver.
    Comprehensive therapy, 1984, Volume: 10, Issue:12

    Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv

1984
Prevalence and nonspecificity of microvesicular fatty change in the liver.
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 1995, Volume: 8, Issue:1

    Topics: Aged; Aged, 80 and over; Aspirin; Fatty Liver; Female; Humans; Male; Middle Aged; Pilot Projects; Ri

1995
Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats.
    Carcinogenesis, 1996, Volume: 17, Issue:3

    Topics: Acetophenones; Animals; Aspirin; Choline; Choline Deficiency; Cyclooxygenase Inhibitors; Fatty Liver

1996
Salicylate intoxication and influenza in ferrets.
    Pediatric research, 1979, Volume: 13, Issue:1

    Topics: Animals; Arginase; Argininosuccinate Lyase; Aspartate Aminotransferases; Aspirin; Carbamoyl-Phosphat

1979
[Reye's syndrome and the administration of acetylsalicylic acid in children].
    Boletin medico del Hospital Infantil de Mexico, 1985, Volume: 42, Issue:6

    Topics: Aspirin; Child; Fatty Liver; Humans; Liver; Muscles; Reye Syndrome; Virus Diseases

1985
[Reye's syndrome--visceral fatty degeneration and encephalopathy].
    Duodecim; laaketieteellinen aikakauskirja, 1985, Volume: 101, Issue:14

    Topics: Aspirin; Brain; Child; Fatty Liver; Humans; Reye Syndrome; Virus Diseases

1985
Reye's syndrome and hyperaminoacidemia.
    The Journal of pediatrics, 1974, Volume: 84, Issue:3

    Topics: Amino Acids; Aspirin; Brain Diseases; Child; Child, Preschool; Diagnosis, Differential; Fatty Liver;

1974
Arthritis, aspirin, and coma.
    The Journal of pediatrics, 1970, Volume: 77, Issue:1

    Topics: Arthritis, Juvenile; Aspirin; Brain Edema; Chemical and Drug Induced Liver Injury; Child, Preschool;

1970
Reye's syndrome and salicylate intoxication.
    Pediatrics, 1970, Volume: 46, Issue:6

    Topics: Adipose Tissue; Aspirin; Brain Diseases; Chemical and Drug Induced Liver Injury; Fatty Liver; Humans

1970