aspirin has been researched along with Experimental Hepatoma in 14 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effects of inhibitors of arachidonic acid (AA) metabolism on the development of fatty liver, cirrhosis, glutathione-S-transferase placental form (GST-P)-positive nodules and the generation of 8-hydroxydeoxyguanosine (8-OHdG) and thiobarbituric acid-reactive substances (TBARS), caused by a choline-deficient, L-amino acid-defined (CDAA) diet, were examined in male Fischer 344 rats by feeding CDAA diets supplemented with the inhibitors for 12 and 30 weeks." | 3.69 | Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats. ( Denda, A; Endoh, T; Horiguchi, K; Kobayashi, E; Konishi, Y; Nakae, D; Noguchi, O; Ogasawara, H; Sugimura, M; Tamura, K; Tang, Q; Tsujiuchi, T, 1996) |
| "The growth rate (studied by mean tumor dry weight) and vascularization (studied by microangiography) of two transplantable rat tumors, a 20-methylcholanthrene-induced fibrosarcoma and a hepatoma, were significantly reduced by three prostaglandin synthesis inhibitors, indomethacin, diclofenac-sodium and aspirin, irrespective of whether the drugs were administered early or late during tumor growth." | 3.66 | Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat. ( Peterson, HI, 1983) |
| "Accelerated progression of residual hepatocellular carcinoma (HCC) after incomplete radiofrequency ablation (RFA) has been reported more frequently." | 1.42 | Inflammation and cancer: inhibiting the progression of residual hepatic VX2 carcinoma by anti-inflammatory drug after incomplete radiofrequency ablation. ( Ding, J; Duan, B; Jiang, T; Lu, S; Zhang, X, 2015) |
| "Although no lung metastasis was observed in the rats killed at the end of the period of carcinogen exposure, lung metastasis was found in 100% of animals in all the groups at the end of the experiment." | 1.32 | Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma. ( Futakuchi, M; Ogawa, K; Shirai, T; Takahashi, S; Tamano, S, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (21.43) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moeini, A | 1 |
| Torrecilla, S | 1 |
| Tovar, V | 1 |
| Montironi, C | 1 |
| Andreu-Oller, C | 1 |
| Peix, J | 1 |
| Higuera, M | 1 |
| Pfister, D | 1 |
| Ramadori, P | 1 |
| Pinyol, R | 1 |
| Solé, M | 1 |
| Heikenwälder, M | 1 |
| Friedman, SL | 1 |
| Sia, D | 1 |
| Llovet, JM | 1 |
| Jiang, T | 1 |
| Zhang, X | 1 |
| Ding, J | 1 |
| Duan, B | 1 |
| Lu, S | 1 |
| Xie, SQ | 1 |
| Zhang, LL | 1 |
| Yang, T | 1 |
| Ma, Y | 1 |
| Zhang, YH | 1 |
| Li, Q | 1 |
| Wang, JH | 1 |
| Zhao, J | 1 |
| Wang, CJ | 1 |
| Tang, LP | 1 |
| Tang, CW | 1 |
| Wang, CH | 1 |
| Futakuchi, M | 2 |
| Ogawa, K | 2 |
| Sano, M | 1 |
| Tamano, S | 2 |
| Takeshita, F | 1 |
| Shirai, T | 2 |
| Takahashi, S | 1 |
| Peterson, HI | 1 |
| Trevisani, A | 1 |
| Ferretti, E | 1 |
| Capuzzo, A | 1 |
| Tomasi, V | 1 |
| Denda, A | 3 |
| Tang, Q | 3 |
| Endoh, T | 2 |
| Tsujiuchi, T | 3 |
| Horiguchi, K | 2 |
| Noguchi, O | 2 |
| Mizumoto, Y | 1 |
| Nakae, D | 2 |
| Konishi, Y | 3 |
| Tsutsumi, M | 1 |
| Amanuma, T | 1 |
| Murata, Y | 1 |
| Maruyama, H | 1 |
| Yokoyama, I | 1 |
| Hayashi, S | 1 |
| Kobayashi, T | 1 |
| Negita, M | 1 |
| Yasutomi, M | 1 |
| Uchida, K | 1 |
| Takagi, H | 1 |
| Kobayashi, E | 1 |
| Tamura, K | 1 |
| Ogasawara, H | 1 |
| Sugimura, M | 1 |
| Uehara, H | 1 |
| Otsuka, H | 1 |
| Izumi, K | 1 |
| Ono, M | 1 |
| Tanaka, N | 1 |
14 other studies available for aspirin and Experimental Hepatoma
| Article | Year |
|---|---|
An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Biomarkers, Tumor; Carcinoma, Hepatocellular; Case-Contro | 2019 |
Inflammation and cancer: inhibiting the progression of residual hepatic VX2 carcinoma by anti-inflammatory drug after incomplete radiofrequency ablation.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Aspirin; Carcinoma, Hepatocellular; Cathet | 2015 |
[Acetylsalicylic acid strengthens the effects of ANISpm against hepatocellular carcinoma and its molecular mechanism].
Topics: Acetyltransferases; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Caspase 8; Caspase 9; Cell L | 2011 |
[Inhibiting effects of aspirin on the growth of human hepatocellular carcinoma].
Topics: Animals; Apoptosis; Aspirin; Cell Division; Dose-Response Relationship, Drug; Humans; Liver Neoplasm | 2002 |
Suppression of lung metastasis by aspirin but not indomethacin in an in vivo model of chemically induced hepatocellular carcinoma.
Topics: Animals; Aspirin; Indomethacin; Intercellular Adhesion Molecule-1; Liver Neoplasms, Experimental; Lu | 2002 |
Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma.
Topics: Acetylcysteine; Animals; Aspirin; Blotting, Western; Carcinogens; Diethylnitrosamine; E-Selectin; En | 2004 |
Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat.
Topics: Animals; Aspirin; Diclofenac; Fibrosarcoma; Indomethacin; Liver Neoplasms, Experimental; Neoplasm Tr | 1983 |
Elevated levels of prostaglandin E2 in Yoshida hepatoma and the inhibition of tumour growth by non-steroidal anti-inflammatory drugs.
Topics: Animals; Arachidonic Acids; Aspirin; Cell Division; Cells, Cultured; Cyclic AMP; Cyclooxygenase Inhi | 1980 |
Prevention by acetylsalicylic acid of liver cirrhosis and carcinogenesis as well as generations of 8-hydroxydeoxyguanosine and thiobarbituric acid-reactive substances caused by a choline-deficient, L-amino acid-defined diet in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amino Acids; Animals; Arachidonic Acid; Aspirin; Choline Deficiency; De | 1994 |
Inhibitory effects of inhibitors of arachidonic acid metabolism on the evolution of rat liver preneoplastic foci into nodules and hepatocellular carcinomas with or without phenobarbital exposure.
Topics: Acetophenones; Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Diethylnitrosamine; Li | 1993 |
Prevention of experimental hepatic metastasis with thromboxane synthase inhibitor.
Topics: Animals; Aspirin; Colonic Neoplasms; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Liver Neoplasms, | 1995 |
Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats.
Topics: Acetophenones; Animals; Aspirin; Choline; Choline Deficiency; Cyclooxygenase Inhibitors; Fatty Liver | 1996 |
Modifying effects of a mixture of acetaminophen, aspirin, dipyrone and ethenzamide on a multiorgan initiation model and its carcinogenicity in male F344 rats.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-St | 1999 |
Augmentation of natural killer activity by neuraminidase treatment of lymphocytes from tumor-bearing mice.
Topics: Animals; Aspirin; Cytotoxicity, Immunologic; Dinoprostone; Indomethacin; Interferons; Killer Cells, | 1986 |