aspirin has been researched along with Endotoxemia in 7 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen was the superior antipyretic drug in endotoxemia compared with aspirin." | 9.09 | Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial. ( Bieglmayer, C; Eichler, HG; Jilma, B; Kapiotis, S; Pernerstorfer, T; Schmid, R, 1999) |
| "Acetaminophen was the superior antipyretic drug in endotoxemia compared with aspirin." | 5.09 | Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial. ( Bieglmayer, C; Eichler, HG; Jilma, B; Kapiotis, S; Pernerstorfer, T; Schmid, R, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kiers, D | 2 |
| van der Heijden, WA | 1 |
| van Ede, L | 1 |
| Gerretsen, J | 2 |
| de Mast, Q | 1 |
| van der Ven, AJ | 1 |
| El Messaoudi, S | 1 |
| Rongen, GA | 1 |
| Gomes, M | 1 |
| Kox, M | 2 |
| Pickkers, P | 2 |
| Riksen, NP | 1 |
| Leijte, GP | 1 |
| van der Heijden, W | 1 |
| Jansen, A | 1 |
| Boerrigter, V | 1 |
| Netea, MG | 1 |
| Derhaschnig, U | 1 |
| Schweeger-Exeli, I | 1 |
| Marsik, C | 1 |
| Cardona, F | 1 |
| Minuz, P | 1 |
| Jilma, B | 3 |
| Paiva, CN | 1 |
| Arras, RH | 1 |
| Lessa, LP | 1 |
| Gibaldi, D | 1 |
| Alves, L | 1 |
| Metz, CN | 1 |
| Gazzinelli, R | 1 |
| Pyrrho, AS | 1 |
| Lannes-Vieira, J | 1 |
| Bozza, MT | 1 |
| Farhadi, A | 1 |
| Gundlapalli, S | 1 |
| Shaikh, M | 1 |
| Frantzides, C | 1 |
| Harrell, L | 1 |
| Kwasny, MM | 1 |
| Keshavarzian, A | 1 |
| Blann, A | 1 |
| Pernerstorfer, T | 2 |
| Stohlawetz, P | 1 |
| Eichler, HG | 2 |
| Vondrovec, B | 1 |
| Amiral, J | 1 |
| Richter, V | 1 |
| Wagner, OF | 1 |
| Schmid, R | 1 |
| Bieglmayer, C | 1 |
| Kapiotis, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Impact of Aspirin Dose Modification on the Innate Immune Response - Will Lower Dose Aspirin Therapy Reduce the Response to Endotoxin[NCT03869268] | Phase 4 | 72 participants (Actual) | Interventional | 2019-04-24 | Completed | ||
| Characterisation of a Novel Regimen of Very Low-dose Aspirin Combined With Rivaroxaban in Patients With Chronic Coronary Syndromes: WILL lOWer Dose Aspirin be Better With Rivaroxaban in Patients With Chronic Coronary Syndromes?[NCT04990791] | Phase 4 | 48 participants (Anticipated) | Interventional | 2021-08-26 | Recruiting | ||
| The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation[NCT01099566] | Phase 4 | 20 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for aspirin and Endotoxemia
| Article | Year |
|---|---|
A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia.
Topics: Adenosine; Administration, Intravenous; Adolescent; Adult; Aspirin; Cells, Cultured; Clopidogrel; Cy | 2017 |
A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia.
Topics: Adenosine; Administration, Intravenous; Adolescent; Adult; Aspirin; Cells, Cultured; Clopidogrel; Cy | 2017 |
A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia.
Topics: Adenosine; Administration, Intravenous; Adolescent; Adult; Aspirin; Cells, Cultured; Clopidogrel; Cy | 2017 |
A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia.
Topics: Adenosine; Administration, Intravenous; Adolescent; Adult; Aspirin; Cells, Cultured; Clopidogrel; Cy | 2017 |
Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.
Topics: Adult; Aged; Aspirin; Dose-Response Relationship, Drug; Double-Blind Method; Endotoxemia; Endotoxins | 2019 |
Effects of aspirin and NO-aspirin (NCX 4016) on platelet function and coagulation in human endotoxemia.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Coagulation; Blood Platelets; Double- | 2010 |
Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Adhesion Molecules; Dou | 1999 |
Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Aspirin; Body Temperature; Double-Blind Method; Endo | 1999 |
2 other studies available for aspirin and Endotoxemia
| Article | Year |
|---|---|
Unraveling the lethal synergism between Trypanosoma cruzi infection and LPS: a role for increased macrophage reactivity.
Topics: Animals; Aspirin; Chagas Disease; Cyclooxygenase Inhibitors; Endotoxemia; Enzyme-Linked Immunosorben | 2007 |
Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Endotoxemia; Fatty Liver; Female; Humans; I | 2008 |