aspirin has been researched along with Endometrial Neoplasms in 28 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the efficacy of fertility-sparing treatment using medroxyprogesterone acetate (MPA) for endometrial carcinoma (EC) and atypical endometrial hyperplasia (AH) in young women." | 9.12 | Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women. ( Fukunaga, M; Hatae, M; Hiura, M; Iwasaka, T; Kamura, T; Kodama, S; Konishi, I; Nakanishi, T; Saito, T; Saji, F; Sakamoto, A; Sasaki, H; Terakawa, N; Tsuda, H; Ushijima, K; Yaegashi, N; Yahata, H; Yasugi, T; Yoshikawa, H, 2007) |
| ": To investigate the effect of aspirin on human Ishikawa adenocarcinoma endometrium cell proliferation and apoptosis and its related mechanism through in vitro experiments." | 7.75 | Experimental research on the depressant effect of aspirin on Ishikawa adenocarcinoma endometrium cell growth. ( Hongwei, L; Shu, L; Xiaoxin, M; Yanxia, L; Yingnan, J; Yuanqi, H, 2009) |
| "Among women with endometrial cancer, aspirin use exerted a modest effect on VTE prophylaxis, whereas statin use was associated with a decreased prevalence of VTE, especially in women with obesity and type II cancer, compared with those in non-users." | 5.72 | Effects of aspirin and statin use on venous thromboembolism prophylaxis and survival in patients with endometrial cancer. ( Klar, M; Matsuo, K; Matsuzaki, S; Miller, H; Takiuchi, T, 2022) |
| "To assess the efficacy of fertility-sparing treatment using medroxyprogesterone acetate (MPA) for endometrial carcinoma (EC) and atypical endometrial hyperplasia (AH) in young women." | 5.12 | Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women. ( Fukunaga, M; Hatae, M; Hiura, M; Iwasaka, T; Kamura, T; Kodama, S; Konishi, I; Nakanishi, T; Saito, T; Saji, F; Sakamoto, A; Sasaki, H; Terakawa, N; Tsuda, H; Ushijima, K; Yaegashi, N; Yahata, H; Yasugi, T; Yoshikawa, H, 2007) |
| ": To investigate the effect of aspirin on human Ishikawa adenocarcinoma endometrium cell proliferation and apoptosis and its related mechanism through in vitro experiments." | 3.75 | Experimental research on the depressant effect of aspirin on Ishikawa adenocarcinoma endometrium cell growth. ( Hongwei, L; Shu, L; Xiaoxin, M; Yanxia, L; Yingnan, J; Yuanqi, H, 2009) |
| "We observed risk reductions in endometrial cancer associated with regular use of aspirin (case-control: 11%, cohort: 8%) and NA-NSAIDs (case-control: 9%, cohort: 6%), compared to non-use." | 2.53 | Non-steroidal anti-inflammatory drug use and risk of endometrial cancer: A systematic review and meta-analysis of observational studies. ( Albieri, V; Dehlendorff, C; Friis, S; Kjaer, SK; Verdoodt, F, 2016) |
| " Subgroup analysis was conducted based on obesity, hormone replacement therapy use, and cancer subtype; sensitivity analysis was conducted by pooling risk ratios of the highest dosage or longest duration of use." | 2.53 | Can Aspirin Reduce the Risk of Endometrial Cancer?: A Systematic Review and Meta-analysis of Observational Studies. ( Bai, B; Xi, Y; Zhang, D; Zhao, Y, 2016) |
| " There was a significant inverse dose-response (p-trend <0." | 2.49 | Aspirin, nonsteroidal anti-inflammatory drugs, paracetamol and risk of endometrial cancer: a case-control study, systematic review and meta-analysis. ( Nagle, CM; Neill, AS; Obermair, A; Protani, MM; Spurdle, AB; Webb, PM, 2013) |
| " However, long-term administration of NSAIDs carries the risk of various side effects, including those in the digestive and circulatory systems." | 1.72 | Biological Activity of ( Kowalczyk, A; Kuźmycz, O; Stączek, P, 2022) |
| "Among women with endometrial cancer, aspirin use exerted a modest effect on VTE prophylaxis, whereas statin use was associated with a decreased prevalence of VTE, especially in women with obesity and type II cancer, compared with those in non-users." | 1.72 | Effects of aspirin and statin use on venous thromboembolism prophylaxis and survival in patients with endometrial cancer. ( Klar, M; Matsuo, K; Matsuzaki, S; Miller, H; Takiuchi, T, 2022) |
| " We found no indication of a dose-response association according to increasing tablet strength, cumulative amount or duration of use, and the HRs were similar for pre-diagnostic and post-diagnostic low-dose aspirin use compared with non-use." | 1.56 | Low-dose aspirin use and endometrial cancer mortality-a Danish nationwide cohort study. ( Aalborg, GL; Dehlendorff, C; Friis, S; Kjaer, SK; Sperling, CD; Verdoodt, F, 2020) |
| " There were also no evidence of a dose-response association between these drug groups and EC survival." | 1.46 | Commonly used medications and endometrial cancer survival: a population-based cohort study. ( Cardwell, CR; Coleman, HG; Mc Menamin, ÚC; Murray, LJ; Sanni, OB; Sharp, L, 2017) |
| "Analyses were stratified by endometrial cancer type, and potential effect modification by parity, obesity, and hormone replacement therapy (HRT) use was investigated." | 1.42 | Use of nonsteroidal anti-inflammatory drugs and risk of endometrial cancer: a nationwide case-control study. ( Baandrup, L; Brøns, N; Dehlendorff, C; Kjaer, SK, 2015) |
| "Data on the role of aspirin on endometrial cancer risk are scanty." | 1.36 | Aspirin and risk of endometrial cancer: a case-control study from Italy. ( Bosetti, C; Bravi, F; La Vecchia, C; Montella, M; Negri, E; Talamini, R, 2010) |
| "NSAID use was unrelated to risk of endometrial cancer in both obese and nonobese women." | 1.35 | Use of nonsteroidal antiinflammatory drugs and risk of endometrial cancer. ( Bodelon, C; Chen, C; Doherty, JA; Rossing, MA; Weiss, NS, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 8 (28.57) | 29.6817 |
| 2010's | 15 (53.57) | 24.3611 |
| 2020's | 4 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Kuźmycz, O | 1 |
| Kowalczyk, A | 1 |
| Stączek, P | 1 |
| Sperling, CD | 1 |
| Verdoodt, F | 3 |
| Aalborg, GL | 1 |
| Dehlendorff, C | 4 |
| Friis, S | 4 |
| Kjaer, SK | 5 |
| Meiser, B | 1 |
| Kaur, R | 1 |
| Kirk, J | 1 |
| Morrow, A | 1 |
| Peate, M | 1 |
| Wong, WKT | 1 |
| McPike, E | 1 |
| Cops, E | 1 |
| Dowson, C | 1 |
| Austin, R | 1 |
| Fine, M | 1 |
| Thrupp, L | 1 |
| Ward, R | 1 |
| Macrae, F | 1 |
| Hiller, JE | 1 |
| Trainer, AH | 1 |
| Mitchell, G | 1 |
| Matsuzaki, S | 1 |
| Miller, H | 1 |
| Takiuchi, T | 2 |
| Klar, M | 1 |
| Matsuo, K | 4 |
| Sanni, OB | 1 |
| Mc Menamin, ÚC | 1 |
| Cardwell, CR | 1 |
| Sharp, L | 1 |
| Murray, LJ | 1 |
| Coleman, HG | 1 |
| Blake, EA | 1 |
| Sood, AK | 2 |
| Brasky, TM | 3 |
| Webb, PM | 2 |
| Na, R | 1 |
| Weiderpass, E | 1 |
| Adami, HO | 1 |
| Anderson, KE | 1 |
| Bertrand, KA | 1 |
| Botteri, E | 1 |
| Brinton, LA | 1 |
| Chen, C | 2 |
| Doherty, JA | 2 |
| Lu, L | 1 |
| McCann, SE | 1 |
| Moysich, KB | 3 |
| Olson, S | 1 |
| Petruzella, S | 1 |
| Palmer, JR | 1 |
| Prizment, AE | 1 |
| Schairer, C | 1 |
| Setiawan, VW | 1 |
| Spurdle, AB | 2 |
| Trabert, B | 1 |
| Wentzensen, N | 1 |
| Wilkens, L | 1 |
| Yang, HP | 1 |
| Yu, H | 1 |
| Risch, HA | 1 |
| Jordan, SJ | 1 |
| Hom, MS | 1 |
| Yabuno, A | 1 |
| Shida, M | 2 |
| Kakuda, M | 2 |
| Adachi, S | 2 |
| Mandelbaum, RS | 1 |
| Ueda, Y | 2 |
| Hasegawa, K | 1 |
| Enomoto, T | 2 |
| Mikami, M | 2 |
| Roman, LD | 2 |
| Tuyaerts, S | 1 |
| Van Nuffel, AMT | 1 |
| Naert, E | 1 |
| Van Dam, PA | 1 |
| Vuylsteke, P | 1 |
| De Caluwé, A | 1 |
| Aspeslagh, S | 1 |
| Dirix, P | 1 |
| Lippens, L | 1 |
| De Jaeghere, E | 1 |
| Amant, F | 1 |
| Vandecasteele, K | 1 |
| Denys, H | 1 |
| Baandrup, L | 2 |
| Olsen, JH | 1 |
| Brøns, N | 1 |
| Nevadunsky, NS | 1 |
| Van Arsdale, A | 1 |
| Strickler, HD | 1 |
| Spoozak, LA | 1 |
| Moadel, A | 1 |
| Kaur, G | 1 |
| Girda, E | 1 |
| Goldberg, GL | 1 |
| Einstein, MH | 1 |
| Albieri, V | 1 |
| Zhang, D | 1 |
| Bai, B | 1 |
| Xi, Y | 1 |
| Zhao, Y | 1 |
| Cahoon, SS | 1 |
| Yoshihara, K | 1 |
| Moeini, A | 1 |
| Machida, H | 1 |
| Garcia-Sayre, J | 1 |
| Xiaoxin, M | 1 |
| Yingnan, J | 1 |
| Yanxia, L | 1 |
| Shu, L | 1 |
| Yuanqi, H | 1 |
| Hongwei, L | 1 |
| Bodelon, C | 1 |
| Rossing, MA | 1 |
| Weiss, NS | 1 |
| Bosetti, C | 1 |
| Bravi, F | 1 |
| Talamini, R | 1 |
| Montella, M | 1 |
| Negri, E | 1 |
| La Vecchia, C | 1 |
| Neill, AS | 1 |
| Nagle, CM | 1 |
| Protani, MM | 1 |
| Obermair, A | 1 |
| Cohn, DE | 1 |
| White, E | 1 |
| Din, FV | 1 |
| Dunlop, MG | 1 |
| Stark, LA | 1 |
| Gao, J | 1 |
| Niwa, K | 1 |
| Sun, W | 1 |
| Takemura, M | 1 |
| Lian, Z | 1 |
| Onogi, K | 1 |
| Seishima, M | 1 |
| Mori, H | 1 |
| Tamaya, T | 1 |
| Baker, JA | 1 |
| Rodabaugh, KJ | 1 |
| Villella, JA | 1 |
| Ushijima, K | 1 |
| Yahata, H | 1 |
| Yoshikawa, H | 1 |
| Konishi, I | 1 |
| Yasugi, T | 1 |
| Saito, T | 2 |
| Nakanishi, T | 1 |
| Sasaki, H | 1 |
| Saji, F | 1 |
| Iwasaka, T | 1 |
| Hatae, M | 1 |
| Kodama, S | 1 |
| Terakawa, N | 1 |
| Yaegashi, N | 1 |
| Hiura, M | 1 |
| Sakamoto, A | 1 |
| Tsuda, H | 1 |
| Fukunaga, M | 1 |
| Kamura, T | 1 |
| Viswanathan, AN | 1 |
| Feskanich, D | 1 |
| Schernhammer, ES | 1 |
| Hankinson, SE | 1 |
| Sato, K | 1 |
| Mori, Y | 1 |
| Okamura, N | 1 |
| Mizuuchi, H | 1 |
| Arango, HA | 1 |
| Icely, S | 1 |
| Roberts, WS | 1 |
| Cavanagh, D | 1 |
| Becker, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Investigation of Pembrolizumab (Keytruda) in Combination With Radiation and an Immune Modulatory Cocktail in Patients With Cervical and Uterine Cancer (PRIMMO Trial)[NCT03192059] | Phase 2 | 43 participants (Actual) | Interventional | 2017-07-01 | Completed | ||
| Value of Levonorgestrel-Releasing Intrauterine System (LNG-IUS) in the Fertility-preserving Treatment of Atypical Endometrial Hyperplasia and Early Endometrial Carcinoma[NCT03463252] | Phase 2/Phase 3 | 224 participants (Anticipated) | Interventional | 2018-04-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for aspirin and Endometrial Neoplasms
| Article | Year |
|---|---|
Influence of aspirin and non-aspirin NSAID use on ovarian and endometrial cancer: Summary of epidemiologic evidence of cancer risk and prognosis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Endometrial Neoplasms; Female; Humans; Ovarian Neo | 2017 |
Aspirin use and endometrial cancer risk and survival.
Topics: Aspirin; Dose-Response Relationship, Drug; Endometrial Neoplasms; Female; Humans | 2018 |
Non-steroidal anti-inflammatory drug use and risk of endometrial cancer: A systematic review and meta-analysis of observational studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Endometrial Neoplasms; Femal | 2016 |
Can Aspirin Reduce the Risk of Endometrial Cancer?: A Systematic Review and Meta-analysis of Observational Studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Endometrial Neop | 2016 |
Aspirin, nonsteroidal anti-inflammatory drugs, paracetamol and risk of endometrial cancer: a case-control study, systematic review and meta-analysis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Australia; Case-Control Studies; Co | 2013 |
2 trials available for aspirin and Endometrial Neoplasms
| Article | Year |
|---|---|
PRIMMO study protocol: a phase II study combining PD-1 blockade, radiation and immunomodulation to tackle cervical and uterine cancer.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Aspirin; Chemoradiotherapy; Curcumin; Cycl | 2019 |
Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women.
Topics: Adult; Aspirin; Carcinoma; Disease-Free Survival; Endometrial Neoplasms; Endometrium; Female; Fertil | 2007 |
21 other studies available for aspirin and Endometrial Neoplasms
| Article | Year |
|---|---|
Biological Activity of
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line, Tumor; Cyclooxygenase 2; Endometrial Ne | 2022 |
Low-dose aspirin use and endometrial cancer mortality-a Danish nationwide cohort study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cause of Death; Co | 2020 |
Evaluation of implementation of risk management guidelines for carriers of pathogenic variants in mismatch repair genes: a nationwide audit of familial cancer clinics.
Topics: Adult; Anticarcinogenic Agents; Aspirin; Colonoscopy; Colorectal Neoplasms; Colorectal Neoplasms, He | 2020 |
Effects of aspirin and statin use on venous thromboembolism prophylaxis and survival in patients with endometrial cancer.
Topics: Anticoagulants; Aspirin; Endometrial Neoplasms; Female; Humans; Hydroxymethylglutaryl-CoA Reductase | 2022 |
Commonly used medications and endometrial cancer survival: a population-based cohort study.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspir | 2017 |
Use of aspirin, other nonsteroidal anti-inflammatory drugs and acetaminophen and risk of endometrial cancer: the Epidemiology of Endometrial Cancer Consortium.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Cont | 2019 |
Association of statins, aspirin, and venous thromboembolism in women with endometrial cancer.
Topics: Aspirin; Endometrial Neoplasms; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inci | 2019 |
Low-dose aspirin use and the risk of ovarian cancer in Denmark.
Topics: Adenocarcinoma, Clear Cell; Adenocarcinoma, Mucinous; Adult; Aged; Aged, 80 and over; Anti-Inflammat | 2015 |
Use of nonsteroidal anti-inflammatory drugs and risk of endometrial cancer: a nationwide case-control study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studi | 2015 |
Association Between Statin Use and Endometrial Cancer Survival.
Topics: Adult; Aged; Aspirin; Endometrial Neoplasms; Female; Follow-Up Studies; Humans; Hydroxymethylglutary | 2015 |
Association of Low-Dose Aspirin and Survival of Women With Endometrial Cancer.
Topics: Adenocarcinoma; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Comorbidity; Diabetes Mellit | 2016 |
Experimental research on the depressant effect of aspirin on Ishikawa adenocarcinoma endometrium cell growth.
Topics: Adenocarcinoma; Apoptosis; Aspirin; bcl-X Protein; Cell Cycle; Cell Line, Tumor; Cell Proliferation; | 2009 |
Use of nonsteroidal antiinflammatory drugs and risk of endometrial cancer.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Mass Index; Case-Control Studies; Drug | 2009 |
Aspirin and risk of endometrial cancer: a case-control study from Italy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-C | 2010 |
Non-steroidal anti-inflammatory drugs and endometrial cancer risk in the VITamins And Lifestyle (VITAL) cohort.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemoprevention; Cohort Studies; Endometrial | 2013 |
Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis.
Topics: Adenomatous Polyposis Coli; Apoptosis; Aspirin; beta Catenin; Breast Neoplasms; Cell Nucleus; Colore | 2004 |
Non-steroidal anti-inflammatory drugs inhibit cellular proliferation and upregulate cyclooxygenase-2 protein expression in endometrial cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Cell Cycle; Cell Proliferation; Cycloox | 2004 |
Regular analgesic use and risk of endometrial cancer.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Mass Index; Case-C | 2005 |
Aspirin, NSAID, and acetaminophen use and the risk of endometrial cancer.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Mass Index; Cohort Stud | 2008 |
[A report of two endometrial cancer cases in that low-dose aspirin was effective for hypercoagulopathy caused by medroxyprogesterone acetate].
Topics: Adenocarcinoma; Adult; Aspirin; Cystadenocarcinoma, Serous; Endometrial Neoplasms; Female; Humans; M | 1995 |
Aspirin effects on endometrial cancer cell growth.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Cell Division; Dose-Response Relationsh | 2001 |