aspirin has been researched along with ER-Negative PR-Negative HER2-Negative Breast Cancer in 12 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Microscopic imaging, the formation of 3D multicellular tumour spheroids, immunocytochemistry, flow cytometry, Annexin V Assay, Caspase 3/7 Apoptosis Assay, tube formation assay and analysis, and WST-1 cell viability assay evaluated the formation of MCTS, morphologic changes, cell viability, apoptosis activity and the expression levels of ALDH1A1, CD44 and CD24 on the cell surface, MDA-MB231 triple-negative breast cancer, tamoxifen (Tmx) resistant variant (MDA-MB-231-TmxR)." | 7.96 | A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer. ( Burov, SV; Haq, S; Harless, W; Markvicheva, E; Qorri, B; Sambi, M; Samuel, V; Szewczuk, MR, 2020) |
| "Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been hypothesized to be associated with reduced risk of breast cancer; however, results of epidemiological studies have been mixed." | 7.96 | Aspirin use and risk of breast cancer in African American women. ( Barber, L; Bertrand, KA; Bethea, TN; Coogan, PF; Gerlovin, H; Palmer, JR; Rosenberg, L, 2020) |
| "Metformin can induce breast cancer (BC) cell apoptosis and reduce BC local and metastatic growth in preclinical models." | 7.83 | Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells. ( Albini, A; Bertolini, F; Calleri, A; Dallaglio, K; Gregato, G; Labanca, V; Mancuso, P; Noonan, DM; Orecchioni, S; Reggiani, F; Rossi, T; Talarico, G, 2016) |
| "Microscopic imaging, the formation of 3D multicellular tumour spheroids, immunocytochemistry, flow cytometry, Annexin V Assay, Caspase 3/7 Apoptosis Assay, tube formation assay and analysis, and WST-1 cell viability assay evaluated the formation of MCTS, morphologic changes, cell viability, apoptosis activity and the expression levels of ALDH1A1, CD44 and CD24 on the cell surface, MDA-MB231 triple-negative breast cancer, tamoxifen (Tmx) resistant variant (MDA-MB-231-TmxR)." | 3.96 | A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer. ( Burov, SV; Haq, S; Harless, W; Markvicheva, E; Qorri, B; Sambi, M; Samuel, V; Szewczuk, MR, 2020) |
| "Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been hypothesized to be associated with reduced risk of breast cancer; however, results of epidemiological studies have been mixed." | 3.96 | Aspirin use and risk of breast cancer in African American women. ( Barber, L; Bertrand, KA; Bethea, TN; Coogan, PF; Gerlovin, H; Palmer, JR; Rosenberg, L, 2020) |
| "Metformin can induce breast cancer (BC) cell apoptosis and reduce BC local and metastatic growth in preclinical models." | 3.83 | Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells. ( Albini, A; Bertolini, F; Calleri, A; Dallaglio, K; Gregato, G; Labanca, V; Mancuso, P; Noonan, DM; Orecchioni, S; Reggiani, F; Rossi, T; Talarico, G, 2016) |
| "However, postsurgical metastasis poses an immense setback in cancer therapy." | 1.51 | Minimal dosing of leukocyte targeting TRAIL decreases triple-negative breast cancer metastasis following tumor resection. ( Himmel, LE; Jyotsana, N; King, MR; Yu, F; Zhang, Z, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 4 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, YS | 1 |
| Kornelius, E | 1 |
| Lo, SC | 1 |
| Wang, YH | 1 |
| Huang, CN | 1 |
| Sambi, M | 1 |
| Samuel, V | 1 |
| Qorri, B | 1 |
| Haq, S | 1 |
| Burov, SV | 1 |
| Markvicheva, E | 1 |
| Harless, W | 1 |
| Szewczuk, MR | 1 |
| Ma, J | 1 |
| Fan, Z | 1 |
| Tang, Q | 1 |
| Xia, H | 1 |
| Zhang, T | 1 |
| Bi, F | 1 |
| Bertrand, KA | 1 |
| Bethea, TN | 1 |
| Gerlovin, H | 1 |
| Coogan, PF | 1 |
| Barber, L | 1 |
| Rosenberg, L | 1 |
| Palmer, JR | 1 |
| Hsieh, CC | 1 |
| Wang, CH | 1 |
| Bhardwaj, A | 1 |
| Singh, H | 1 |
| Trinidad, CM | 1 |
| Albarracin, CT | 1 |
| Hunt, KK | 1 |
| Bedrosian, I | 1 |
| Jyotsana, N | 1 |
| Zhang, Z | 1 |
| Himmel, LE | 1 |
| Yu, F | 1 |
| King, MR | 1 |
| Harrington, M | 1 |
| Lee, YR | 1 |
| Kim, KM | 1 |
| Jeon, BH | 1 |
| Choi, S | 1 |
| Talarico, G | 1 |
| Orecchioni, S | 1 |
| Dallaglio, K | 1 |
| Reggiani, F | 1 |
| Mancuso, P | 1 |
| Calleri, A | 1 |
| Gregato, G | 1 |
| Labanca, V | 1 |
| Rossi, T | 1 |
| Noonan, DM | 1 |
| Albini, A | 1 |
| Bertolini, F | 1 |
| Shiao, J | 1 |
| Thomas, KM | 1 |
| Rahimi, AS | 1 |
| Rao, R | 1 |
| Yan, J | 1 |
| Xie, XJ | 1 |
| DaSilva, M | 1 |
| Spangler, A | 1 |
| Leitch, M | 1 |
| Wooldridge, R | 1 |
| Rivers, A | 1 |
| Farr, D | 1 |
| Haley, B | 1 |
| Kim, DW | 1 |
| Altundag, K | 1 |
12 other studies available for aspirin and ER-Negative PR-Negative HER2-Negative Breast Cancer
| Article | Year |
|---|---|
Aspirin and Risk of Specific Breast Cancer Subtype in Women with Diabetes.
Topics: Aspirin; Breast Neoplasms; Diabetes Mellitus; Female; Hormones; Humans; Middle Aged; Retrospective S | 2023 |
A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer.
Topics: Aldehyde Dehydrogenase 1 Family; Antineoplastic Agents; Apoptosis; Aspirin; Breast Neoplasms; CD24 A | 2020 |
Aspirin attenuates YAP and β-catenin expression by promoting β-TrCP to overcome docetaxel and vinorelbine resistance in triple-negative breast cancer.
Topics: Animals; Aspirin; beta Catenin; Cell Cycle Proteins; Disease Models, Animal; Drug Resistance, Neopla | 2020 |
Aspirin use and risk of breast cancer in African American women.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Black or African American; Breast Neo | 2020 |
Aspirin Disrupts the Crosstalk of Angiogenic and Inflammatory Cytokines between 4T1 Breast Cancer Cells and Macrophages.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Cell Line, Tumor | 2018 |
The isomiR-140-3p-regulated mevalonic acid pathway as a potential target for prevention of triple negative breast cancer.
Topics: Animals; Aspirin; Biomarkers, Tumor; Biosynthetic Pathways; Cell Line, Tumor; Cell Transformation, N | 2018 |
Minimal dosing of leukocyte targeting TRAIL decreases triple-negative breast cancer metastasis following tumor resection.
Topics: Animals; Apoptosis; Aspirin; Cell Line, Tumor; Cell Proliferation; Curcumin; Dioxolanes; E-Selectin; | 2019 |
An aspirin a day keeps cancer at bay?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antineoplastic Agents, Horm | 2013 |
Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation.
Topics: Acetylation; Antigens, Neoplasm; Apoptosis; Aspirin; Breast Neoplasms; Cell Line, Tumor; Cell Membra | 2015 |
Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells.
Topics: Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Asp | 2016 |
Aspirin/antiplatelet agent use improves disease-free survival and reduces the risk of distant metastases in Stage II and III triple-negative breast cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Breast Neop | 2017 |
Association between aspirin use triple negative breast cancer: More benefit is expected.
Topics: Aspirin; Breast Neoplasms; Cohort Studies; Humans; Receptor, ErbB-2; Receptors, Estrogen; Receptors, | 2017 |