aspirin has been researched along with Duodenal Diseases in 27 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Duodenal Diseases: Pathological conditions in the DUODENUM region of the small intestine (INTESTINE, SMALL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous erosive oesophagitis studies have excluded patients with peptic ulcers or taking aspirin, and conflicting results have been reported concerning the influence of." | 7.71 | Correlation between erosive oesophageal and gastro-duodenal diseases. the influence of aspirin, simple analgesics, and Helicobacter pylori. ( Angerson, WJ; Morran, CG; Taha, AS, 2002) |
| "Ninety-one normal, healthy volunteers participated in a single-center, double-blind, placebo-controlled, randomized, parallel group study: 1) to compare the prostaglandin E1 analog, misoprostol, given at a dose of 200 micrograms bid, with the recommended dose of 200 micrograms qid in protecting the gastroduodenal mucosa against injury due to anti-inflammatory doses of aspirin (3900 mg/day); and 2) to determine whether the reduced dose was associated with a lesser incidence of gastrointestinal (GI) side effects, particularly diarrhea." | 5.07 | A double-blind, placebo-controlled, 6-day evaluation of two doses of misoprostol in gastroduodenal mucosal protection against damage from aspirin and effect on bowel habits. ( Deysach, LG; Geis, GS; Kochman, RL; Lanza, FL; Rack, EM, 1991) |
| " We report IDH secondary to aspirin therapy that was associated with transient obstructive jaundice and acute cholecystitis in a 47-year-old woman." | 3.76 | Spontaneous intramural duodenal haematoma with transient biliary obstruction and acute cholecystitis. ( Basir, N; Chong, VH, 2010) |
| "Previous erosive oesophagitis studies have excluded patients with peptic ulcers or taking aspirin, and conflicting results have been reported concerning the influence of." | 3.71 | Correlation between erosive oesophageal and gastro-duodenal diseases. the influence of aspirin, simple analgesics, and Helicobacter pylori. ( Angerson, WJ; Morran, CG; Taha, AS, 2002) |
| "A prospective endoscopic study was carried out in 65 patients with rheumatoid arthritis to assess the prevalence of gastroduodenal lesions on aspirin alone or aspirin plus another anti-inflammatory drug (n = 26)." | 3.66 | Effect of anti-inflammatory drug administration in patients with rheumatoid arthritis. An endoscopic assessment. ( Butt, JH; Grandione, J; Hewitt, J; Holt, SD; Ivey, KJ; Morris, AD; Silvoso, GR; Tatum, W, 1981) |
| "pylori gastritis was present than when it was absent, despite similar degrees of gastric mucosal prostaglandin depletion." | 2.70 | Role of Helicobacter pylori infection in gastroduodenal injury and gastric prostaglandin synthesis during long term/low dose aspirin therapy: a prospective placebo-controlled, double-blind randomized trial. ( Cryer, B; Feldman, M; Go, MF; Mallat, D, 2001) |
| "Study 1: In this double-blind study 18 volunteers received randomized dosing with either EC-ASA 100 mg or placebo for 15 days." | 2.69 | Enteric coating of aspirin significantly decreases gastroduodenal mucosal lesions. ( Burkhardt, F; Dammann, HG; Wolf, N, 1999) |
| " However, the use of ASA and, indeed, other non-steroidal anti-inflammatory drugs (NSAIDs) is limited by the incidence of adverse gastroduodenal events." | 2.45 | Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugs. ( Brailsford, W; Hawkey, CJ; Naesdal, J; Yeomans, ND, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (33.33) | 18.7374 |
| 1990's | 7 (25.93) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 6 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Valkhoff, VE | 1 |
| Sturkenboom, MC | 1 |
| Hill, C | 1 |
| Veldhuyzen van Zanten, S | 1 |
| Kuipers, EJ | 1 |
| Rotondano, G | 1 |
| Telaku, S | 1 |
| Kraja, B | 1 |
| Qirjako, G | 1 |
| Prifti, S | 1 |
| Fejza, H | 1 |
| Kanbayashi, Y | 1 |
| Konishi, H | 1 |
| Lai, LH | 1 |
| Chan, FK | 1 |
| Yeomans, ND | 1 |
| Hawkey, CJ | 1 |
| Brailsford, W | 1 |
| Naesdal, J | 1 |
| Basir, N | 1 |
| Chong, VH | 1 |
| Burri, E | 1 |
| Toia, D | 1 |
| Meier, R | 1 |
| Taha, AS | 1 |
| Angerson, WJ | 1 |
| Morran, CG | 1 |
| Hoftiezer, JW | 1 |
| Silvoso, GR | 3 |
| Burks, M | 1 |
| Ivey, KJ | 3 |
| Börsch, G | 1 |
| Schmidt, G | 1 |
| Bretagne, JF | 1 |
| Feuillu, A | 1 |
| Gosselin, M | 1 |
| Gastard, J | 1 |
| Morris, AD | 1 |
| Holt, SD | 1 |
| Hewitt, J | 1 |
| Tatum, W | 1 |
| Grandione, J | 1 |
| Butt, JH | 2 |
| Lockard, OO | 1 |
| Sisk, C | 1 |
| Holt, S | 1 |
| Saldanha, R | 1 |
| Srikrishna, SV | 1 |
| John, AK | 1 |
| Kordecki, H | 1 |
| Kurowski, M | 1 |
| Kosik, R | 1 |
| Pilecka, D | 1 |
| García-Sancho Martín, L | 1 |
| Dibuz, M | 1 |
| Szabó, T | 1 |
| Monoki, E | 1 |
| Nagymélykuti, L | 1 |
| Illyés, M | 1 |
| Varga, E | 1 |
| Csípö, L | 1 |
| Dammann, HG | 1 |
| Burkhardt, F | 1 |
| Wolf, N | 1 |
| Feldman, M | 1 |
| Cryer, B | 1 |
| Mallat, D | 1 |
| Go, MF | 1 |
| Salawu, L | 1 |
| Olaomi, OO | 1 |
| Paul-Odo, B | 1 |
| Olayinka, OS | 1 |
| Durosinmi, MA | 1 |
| Faivre, J | 1 |
| Faivre, M | 1 |
| Lery, N | 1 |
| Ducluzeau, R | 1 |
| Moulinier, B | 1 |
| Paliard, P | 1 |
| Lanza, FL | 2 |
| Kochman, RL | 1 |
| Geis, GS | 1 |
| Rack, EM | 1 |
| Deysach, LG | 1 |
| Jaszewski, R | 1 |
| Royer, GL | 1 |
| Nelson, RS | 1 |
| Rack, MF | 1 |
| Seckman, CC | 1 |
| Hájek, M | 1 |
| Vlasák, V | 1 |
| Horák, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study Evaluating the Gastroprotective Effect of Carvedilol in Patients With Ischemic Heart Disease on Aspirin Therapy[NCT05553717] | 66 participants (Anticipated) | Interventional | 2022-10-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for aspirin and Duodenal Diseases
| Article | Year |
|---|---|
Low-dose acetylsalicylic acid use and the risk of upper gastrointestinal bleeding: a meta-analysis of randomized clinical trials and observational studies.
Topics: Aspirin; Cardiovascular Diseases; Duodenal Diseases; Esophageal Diseases; Gastrointestinal Hemorrhag | 2013 |
Epidemiology and diagnosis of acute nonvariceal upper gastrointestinal bleeding.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Diseases; Endoscopy, Gastr | 2014 |
Nonsteroid anti-inflammatory drug-induced gastroduodenal injury.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Cyclooxygenase Inhibitors; Drug Inter | 2009 |
Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Dose-Response Relationship, Drug; Drug- | 2009 |
[Drug-induced lesions in the upper gastrointestinal tract].
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Arthritis, Rheumatoid; Aspirin; Cheilitis; Drug-Rela | 1984 |
[Gastric and duodenal intramural hematoma: report of two cases].
Topics: Adult; Aspirin; Chronic Disease; Duodenal Diseases; Gastric Mucosa; Hematoma; Humans; Intestinal Muc | 1998 |
6 trials available for aspirin and Duodenal Diseases
| Article | Year |
|---|---|
Comparison of the effects of regular and enteric-coated aspirin on gastroduodenal mucosa of man.
Topics: Adult; Aspirin; Duodenal Diseases; Duodenum; Erythema; Gastric Mucosa; Humans; Intestinal Mucosa; Py | 1980 |
[Aspirin and gastroduodenal toxicity. A double-blind endoscopic study of the effects of placebo, aspirin and lysine acetylsalicylate in healthy subjects].
Topics: Adult; Aspirin; Double-Blind Method; Duodenal Diseases; Duodenum; Endoscopy; Female; Gastric Mucosa; | 1984 |
Enteric coating of aspirin significantly decreases gastroduodenal mucosal lesions.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Double-Blind Method; Du | 1999 |
Role of Helicobacter pylori infection in gastroduodenal injury and gastric prostaglandin synthesis during long term/low dose aspirin therapy: a prospective placebo-controlled, double-blind randomized trial.
Topics: Adolescent; Adult; Antibodies, Bacterial; Aspirin; Blood Platelets; Cyclooxygenase 1; Double-Blind M | 2001 |
A double-blind, placebo-controlled, 6-day evaluation of two doses of misoprostol in gastroduodenal mucosal protection against damage from aspirin and effect on bowel habits.
Topics: Adult; Aspirin; Diarrhea; Double-Blind Method; Duodenal Diseases; Duodenoscopy; Female; Gastric Muco | 1991 |
Ethanol, aspirin, ibuprofen, and the gastroduodenal mucosa: an endoscopic assessment.
Topics: Adult; Aspirin; Drug Interactions; Drug Synergism; Duodenal Diseases; Ethanol; Female; Gastric Mucos | 1985 |
15 other studies available for aspirin and Duodenal Diseases
| Article | Year |
|---|---|
Clinical outcomes of nonvariceal upper gastrointestinal bleeding in Kosova.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; An | 2014 |
Predictive Factors for NSAIDs-related Gastrointestinal Toxicity: Can COX-2 Selective Inhibtor Prevent it?.
Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antineoplast | 2015 |
Spontaneous intramural duodenal haematoma with transient biliary obstruction and acute cholecystitis.
Topics: Aspirin; Cholecystitis, Acute; Cholestasis, Extrahepatic; Duodenal Diseases; Female; Gastrointestina | 2010 |
Triple pylorus.
Topics: Abdominal Pain; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Diseases; Endoscopy | 2012 |
Correlation between erosive oesophageal and gastro-duodenal diseases. the influence of aspirin, simple analgesics, and Helicobacter pylori.
Topics: Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy; Duode | 2002 |
Effect of anti-inflammatory drug administration in patients with rheumatoid arthritis. An endoscopic assessment.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Drug Therapy, Combination; Duodenal Diseas | 1981 |
The prevalence of duodenal lesions in patients with rheumatic diseases on chronic aspirin therapy.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Buffers; Duodenal Diseases; Duodenal Ulcer; Endoscopy; | 1980 |
Acute duodenal perforation after coronary artery bypass grafting.
Topics: Acute Disease; Aspirin; Coronary Artery Bypass; Duodenal Diseases; Humans; Intestinal Perforation; M | 1994 |
Is Helicobacter pylori infection a risk or protective factor for mucosal lesions development in patients chronically treated with acetylsalicylic acid?
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Dru | 1997 |
[Aspirin and surgery].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Diseases; Endoscopy; Gastroi | 1997 |
Aspirin-induced duodenal perforation in a Nigerian with sickle cell disease: a case report.
Topics: Adult; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Diseases; Hum | 2001 |
Aspirin and gastrointestional bleeding. Interest of plasma salicylate determination.
Topics: Aspirin; Duodenal Diseases; Enteritis; Gastritis; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer | 1979 |
Frequency of gastroduodenal lesions in asymptomatic patients on chronic aspirin or nonsteroidal antiinflammatory drug therapy.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Diseases; Endoscopy; Female; | 1990 |
[Gastric and duodenal hemorrhage after drug administration].
Topics: Analgesics; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Chloramphenicol; Duodenal Diseases; G | 1973 |
[Round table discussion of gastric ulcer].
Topics: Aspirin; Cortisone; Duodenal Diseases; Gastric Juice; Gastritis; Humans; Ischemia; Stomach Ulcer; St | 1968 |