aspirin has been researched along with Drug-Related Side Effects and Adverse Reactions in 148 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with acute minor ischemic stroke or high-risk transient ischemic attack enrolled in the POINT trial (Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke [POINT] Trial), the combination of clopidogrel and aspirin for 90 days reduced major ischemic events but increased major hemorrhage in comparison to aspirin alone." | 9.30 | Time Course for Benefit and Risk of Clopidogrel and Aspirin After Acute Transient Ischemic Attack and Minor Ischemic Stroke. ( Albers, GW; Barsan, WG; Cucchiara, BL; Easton, JD; Elm, JJ; Farrant, M; Johnston, SC; Kim, AS; Kleindorfer, DO; Lindblad, AS; Lutsep, HL; Palesch, YY; Pearson, C; Sethi, P; Vora, N; Zurita, KG, 2019) |
| "Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel reduces the risk for recurrent cardiovascular events after acute coronary syndrome (ACS)." | 7.88 | Pharmacogenetic and clinical predictors of response to clopidogrel plus aspirin after acute coronary syndrome in Egyptians. ( Cavallari, LH; El Wakeel, LL; Fathy, S; Khalil, BM; Langaee, T; Sabry, NA; Saleh, A; Schaalan, MF; Shahin, MH, 2018) |
| "In this observational study, aspirin use was not associated with an increase in mortality rates or HF readmission rates, and aspirin did not attenuate the benefits of ACE inhibitors, even in patients without coronary disease, patients with renal dysfunction, or patients treated with high-dose aspirin and low-dose ACE inhibitors." | 7.73 | Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure. ( Armstrong, PW; Fang, J; Ghali, WA; Gong, Y; McAlister, FA; Tu, JV, 2006) |
| " Increased risks were, in addition, found for tetracyclines, nitrofurantoin and a history of allergic asthma and a decreased risk found for rheumatic symptoms." | 7.69 | Acetaminophen, some other drugs, some diseases and the risk of transitional cell carcinoma. A population-based case-control study. ( Gerhardsson de Verdier, M; Steineck, G; Wiholm, BE, 1995) |
| "0) combined with ASA (mean dose ≥100 mg/day) and ASA." | 6.55 | Efficacy and safety of aspirin combined with warfarin after acute coronary syndrome : A meta-analysis. ( Huang, X; Li, J; Li, L; Shen, C; Wu, C; Zhang, P; Zhang, W, 2017) |
| "Omeprazole was superior to famotidine with less gastrointestinal symptoms and recurrent ulcers/erosions in patients using 24-week low-dose aspirin." | 5.40 | Comparison of proton pump inhibitor and histamine-2 receptor antagonist in the prevention of recurrent peptic ulcers/erosions in long-term low-dose aspirin users: a retrospective cohort study. ( Chan, HH; Chen, WC; Cheng, JS; Chiang, PH; Lai, KH; Li, YD; Tsai, TJ; Tsai, WL; Tsay, FW; Wang, EM, 2014) |
| "In patients with acute minor ischemic stroke or high-risk transient ischemic attack enrolled in the POINT trial (Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke [POINT] Trial), the combination of clopidogrel and aspirin for 90 days reduced major ischemic events but increased major hemorrhage in comparison to aspirin alone." | 5.30 | Time Course for Benefit and Risk of Clopidogrel and Aspirin After Acute Transient Ischemic Attack and Minor Ischemic Stroke. ( Albers, GW; Barsan, WG; Cucchiara, BL; Easton, JD; Elm, JJ; Farrant, M; Johnston, SC; Kim, AS; Kleindorfer, DO; Lindblad, AS; Lutsep, HL; Palesch, YY; Pearson, C; Sethi, P; Vora, N; Zurita, KG, 2019) |
| "Following mechanical valve replacement, combined low dose aspirin and warfarin therapy was associated with a greater reduction in thromboembolism events than warfarin therapy alone." | 5.15 | Anticoagulation therapy with combined low dose aspirin and warfarin following mechanical heart valve replacement. ( Chai, SD; Dong, MF; Ma, SJ; Ma, ZS; Tang, PZ; Wang, LX; Yao, DK, 2011) |
| " The most reported triplet were apixaban-aspirin-gastrointestinal hemorrhage." | 5.05 | Drug interactions with apixaban: A systematic review of the literature and an analysis of VigiBase, the World Health Organization database of spontaneous safety reports. ( Fernandez, S; Lenoir, C; Rollason, V; Samer, C, 2020) |
| " Known side effects of aspirin-tinnitus, deafness, and gastrointestinal disturbance-were more efficiently shown and symptoms not included in the check list were more likely to be reported when a check list was not used." | 5.04 | Measurement of side effects of drugs. ( Huskisson, EC; Wojtulewski, JA, 1974) |
| "The safety of fixed-dose combination aspirin-extended-release (ER) dipyridamole for stroke prevention in patients with ischemic heart disease is reviewed." | 4.86 | Safety of fixed-dose aspirin-extended-release dipyridamole in patients with ischemic heart disease. ( Crown, N; Mysak, T, 2010) |
| " Some local complications are destruction of teeth due to the intake of medicines with high sugar content; erosive lesions of the oral mucosa; paraformaldehyde necrosis; and those arising from the use of chlorhexidine." | 4.77 | Complications in patients on therapeutic drugs. ( Petersen, JK, 1986) |
| "Background Aspirin-exacerbated respiratory disease (AERD), also known as Samter's triad or aspirin (ASA)-intolerant asthma, affects 7% of asthmatics and has a higher prevalence in those with chronic rhinosinusitis and concomitant nasal polyposis." | 3.88 | Long-term Clinical Outcomes of Aspirin Desensitization With Continuous Daily Aspirin Therapy in Aspirin-exacerbated Respiratory Disease. ( Waldram, JD; Walters, KM; White, AA; Woessner, KM, 2018) |
| "Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel reduces the risk for recurrent cardiovascular events after acute coronary syndrome (ACS)." | 3.88 | Pharmacogenetic and clinical predictors of response to clopidogrel plus aspirin after acute coronary syndrome in Egyptians. ( Cavallari, LH; El Wakeel, LL; Fathy, S; Khalil, BM; Langaee, T; Sabry, NA; Saleh, A; Schaalan, MF; Shahin, MH, 2018) |
| "Sarpogrelate-containing triple antiplatelet therapy demonstrated comparable rates of MACCE prevention to the conventional dual antiplatelet therapy after PCI without significantly increasing bleeding risk during the two-year follow-up period." | 3.83 | Antiplatelet Therapy of Cilostazol or Sarpogrelate with Aspirin and Clopidogrel after Percutaneous Coronary Intervention: A Retrospective Cohort Study Using the Korean National Health Insurance Claim Database. ( Bae, SK; Kim, GJ; Kim, JH; Lee, J; Lee, S; Lim, HS; Noh, Y; Oh, E; Shin, S, 2016) |
| "This ecological comparison of bleeding reports and dispensed prescriptions showed a signal towards a higher prevalence of bleeding reports in women on clopidogrel treatment while the opposite was found for low-dose aspirin." | 3.80 | Sex differences in spontaneous reports on adverse bleeding events of antithrombotic treatment. ( Holm, L; Loikas, D; Malmström, RE; Mejyr, S; Rydberg, DM; Schenck-Gustafsson, K; von Euler, M; Wettermark, B, 2014) |
| " Bleeding caused by some combination of nonsteroidal antiinflammatory drugs (NSAIDs), cyclooxygenase-2-selective NSAIDS, aspirin, and clopidogrel was the most common reason for ADR-related MICU admissions." | 3.74 | Admissions to a medical intensive care unit related to adverse drug reactions. ( Rivkin, A, 2007) |
| "In this observational study, aspirin use was not associated with an increase in mortality rates or HF readmission rates, and aspirin did not attenuate the benefits of ACE inhibitors, even in patients without coronary disease, patients with renal dysfunction, or patients treated with high-dose aspirin and low-dose ACE inhibitors." | 3.73 | Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure. ( Armstrong, PW; Fang, J; Ghali, WA; Gong, Y; McAlister, FA; Tu, JV, 2006) |
| " The medications were pravastatin, a cholesterol-lowering drug for the prevention of cardiovascular disease; alendronate, a bisphosphonate for the treatment and prevention of osteoporosis; and aspirin, which is used for the prevention of cardiovascular disease." | 3.70 | Coverage by the news media of the benefits and risks of medications. ( Bero, L; Henry, D; Lee, K; Mah, C; Moynihan, R; Ross-Degnan, D; Soumerai, SB; Watkins, J, 2000) |
| " Increased risks were, in addition, found for tetracyclines, nitrofurantoin and a history of allergic asthma and a decreased risk found for rheumatic symptoms." | 3.69 | Acetaminophen, some other drugs, some diseases and the risk of transitional cell carcinoma. A population-based case-control study. ( Gerhardsson de Verdier, M; Steineck, G; Wiholm, BE, 1995) |
| " Efficacy outcomes included ischemic stroke, stent thrombosis, major adverse cardiovascular event (MACE), all-cause mortality and myocardial infarction (MI); safety outcome was major bleeding." | 2.58 | Efficacy and safety of triple therapy versus dual antiplatelet therapy in patients with atrial fibrillation undergoing coronary stenting: A meta-analysis. ( Huang, J; Liu, L; Tang, X; Zhang, X, 2018) |
| "0) combined with ASA (mean dose ≥100 mg/day) and ASA." | 2.55 | Efficacy and safety of aspirin combined with warfarin after acute coronary syndrome : A meta-analysis. ( Huang, X; Li, J; Li, L; Shen, C; Wu, C; Zhang, P; Zhang, W, 2017) |
| "Unlike heart attacks, stroke and cancer, GI bleeding is an acute event, usually followed by complete recovery." | 2.53 | Systematic Review and Meta-Analysis of Randomised Trials to Ascertain Fatal Gastrointestinal Bleeding Events Attributable to Preventive Low-Dose Aspirin: No Evidence of Increased Risk. ( Chia, JW; Dolwani, S; Elwood, PC; Galante, J; Graziano, JM; Kelson, M; Lanas, A; Longley, M; Morgan, G; Morris, D; Phillips, CJ; Pickering, J; Roberts, SE; Soon, SS; Steward, W; Weightman, AL, 2016) |
| " However, the use of ASA and, indeed, other non-steroidal anti-inflammatory drugs (NSAIDs) is limited by the incidence of adverse gastroduodenal events." | 2.45 | Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugs. ( Brailsford, W; Hawkey, CJ; Naesdal, J; Yeomans, ND, 2009) |
| "If acetylsalicylic acid therapy is maintained, short-term discontinuation of a thienopyridine may be relatively safe in patients with drug-eluting stents." | 2.45 | Safety of short-term discontinuation of antiplatelet therapy in patients with drug-eluting stents. ( Eisenberg, MJ; Filion, KB; Libersan, D; Richard, PR, 2009) |
| "Migraine is often associated with health consequences including impaired quality of life, and the cost of treating migraine headaches places a significant financial burden on patients who suffer from migraines." | 2.44 | Efficacy and safety of 1,000 mg effervescent aspirin: individual patient data meta-analysis of three trials in migraine headache and migraine accompanying symptoms. ( Diener, HC; Lampl, C; Voelker, M, 2007) |
| " The review establishes that aspirin, paracetamol and ibuprofen are safe in OTC doses and that there is no evidence for any difference between the medicines as regards efficacy and safety for treatment of colds and flu (except in certain cases such as the use of aspirin in feverish children)." | 2.43 | Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu. ( Eccles, R, 2006) |
| "Reports of drug-induced pulmonary disease from other countries are also reviewed." | 2.38 | Drug-induced pulmonary disease. ( Bryant, DH, 1992) |
| "The aim of this study is to assess patterns of potential drug-drug interactions (DDIs) with direct oral anticoagulants (DOACs) in an inpatient hospital setting." | 1.56 | Evaluation of Potential Drug-Drug Interactions With Direct Oral Anticoagulants in a Large Urban Hospital. ( Karakas-Torgut, A; Mo, Y; Pham, AQ, 2020) |
| "Aspirin was the most commonly used drug, some hypertensive patients were taking aspirin without being on concomitant antihypertensive drugs." | 1.51 | Inappropriate drug use in the elderly outpatient population in a West-African metropolitan community . ( Amao, O; Arikawe, A; Megbuwawon, T; Ogunyemi, A; Olusanya, A, 2019) |
| "Nonsteroidal anti-inflammatory drugs (NSAIDs), which are globally prescribed, exhibit mainly anti-inflammatory and analgesic effects but also can cause adverse effects including gastrointestinal erosions, ulceration, bleeding, and perforation." | 1.43 | (1)H-Nuclear magnetic resonance-based metabolic profiling of nonsteroidal anti-inflammatory drug-induced adverse effects in rats. ( Choi, KH; Chung, MW; Lee, HJ; Park, JH; Um, SY, 2016) |
| "Background Drug-drug interactions in patients taking warfarin may contribute to a higher risk of adverse events." | 1.43 | Study of warfarin utilization in hospitalized patients: analysis of possible drug interactions. ( Camargo, HP; Girotto, E; Guidoni, CM; Obreli-Neto, PR; Pereira, LR, 2016) |
| "Omeprazole was superior to famotidine with less gastrointestinal symptoms and recurrent ulcers/erosions in patients using 24-week low-dose aspirin." | 1.40 | Comparison of proton pump inhibitor and histamine-2 receptor antagonist in the prevention of recurrent peptic ulcers/erosions in long-term low-dose aspirin users: a retrospective cohort study. ( Chan, HH; Chen, WC; Cheng, JS; Chiang, PH; Lai, KH; Li, YD; Tsai, TJ; Tsai, WL; Tsay, FW; Wang, EM, 2014) |
| "We assessed the safety of thrombolysis under APs in 11,865 patients compliant with the European license criteria and recorded between 2002 and 2007 in the Safe Implementation of Treatments in Stroke (SITS) International Stroke Thrombolysis Register (SITS-ISTR)." | 1.36 | Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset. ( Ahmed, N; Diedler, J; Ford, GA; Lees, KR; Luijckx, GJ; Overgaard, K; Ringleb, P; Soinne, L; Sykora, M; Uyttenboogaart, M; Wahlgren, N, 2010) |
| " The physicians accepted 86% of the recommendations to initiate low dosage ASA and treatment was implemented for 63% of the patients." | 1.33 | Drug-related problems in general practice: results from a development project in Denmark. ( Dinsen, C; Herborg, H; Kirkeby, B; Kjellberg, J; Soendergaard, B; Staehr, P, 2006) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| "Determination of potential drug toxicity and side effect in early stages of drug development is important in reducing the cost and time of drug discovery." | 1.31 | Prediction of potential toxicity and side effect protein targets of a small molecule by a ligand-protein inverse docking approach. ( Chen, YZ; Ung, CY, 2001) |
| " Desensitization, when essential, may be achieved for most drugs with graduated dosage schedules and maintained through continued administration of the drug." | 1.27 | Management of adverse drug reactions. ( Pennoyer, DS; Sheffer, AL, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 63 (42.57) | 18.7374 |
| 1990's | 5 (3.38) | 18.2507 |
| 2000's | 30 (20.27) | 29.6817 |
| 2010's | 44 (29.73) | 24.3611 |
| 2020's | 6 (4.05) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Yamashiro, K | 1 |
| Jouta, M | 1 |
| Hosomi, K | 1 |
| Yokoyama, S | 1 |
| Ozaki, Y | 1 |
| Hirata, A | 1 |
| Ogata, F | 1 |
| Nakamura, T | 1 |
| Tanei, S | 1 |
| Kawasaki, N | 1 |
| Hahn, J | 1 |
| Appel, H | 1 |
| Scheithauer, MO | 1 |
| Petereit, F | 1 |
| Greve, J | 1 |
| Lindemann, J | 1 |
| Hoffmann, TK | 1 |
| Veit, JA | 1 |
| Sommer, F | 1 |
| Hagiwara, H | 1 |
| Fukuta, H | 1 |
| Niimura, T | 1 |
| Zamami, Y | 1 |
| Ishizawa, K | 1 |
| Kimura, K | 1 |
| Kamiya, T | 1 |
| Ohte, N | 1 |
| Sangma, JW | 1 |
| Anal, SRN | 1 |
| Pal, V | 1 |
| Fernandez, S | 1 |
| Lenoir, C | 1 |
| Samer, C | 1 |
| Rollason, V | 1 |
| Martin, AC | 1 |
| Houssany-Pissot, S | 1 |
| Zlotnik, D | 1 |
| Taylor, G | 1 |
| Godier, A | 1 |
| Walters, KM | 1 |
| Waldram, JD | 1 |
| Woessner, KM | 1 |
| White, AA | 1 |
| Lim, JW | 1 |
| Chee, SX | 1 |
| Wong, WJ | 1 |
| He, QL | 1 |
| Lau, TC | 1 |
| Liu, L | 2 |
| Huang, J | 1 |
| Zhang, X | 1 |
| Tang, X | 1 |
| Mo, Y | 1 |
| Karakas-Torgut, A | 1 |
| Pham, AQ | 1 |
| Lichtenberger, LM | 1 |
| Burge, S | 1 |
| Fathy, S | 1 |
| Shahin, MH | 1 |
| Langaee, T | 1 |
| Khalil, BM | 1 |
| Saleh, A | 1 |
| Sabry, NA | 1 |
| Schaalan, MF | 1 |
| El Wakeel, LL | 1 |
| Cavallari, LH | 1 |
| Argiz, L | 1 |
| Múgica, MV | 1 |
| Vega, F | 1 |
| Blanco, C | 1 |
| Bustamante, R | 1 |
| Earles, A | 1 |
| Murphy, JD | 1 |
| Bryant, AK | 1 |
| Patterson, OV | 1 |
| Gawron, AJ | 1 |
| Kaltenbach, T | 1 |
| Whooley, MA | 1 |
| Fisher, DA | 1 |
| Saini, SD | 1 |
| Gupta, S | 1 |
| Weitz, JI | 1 |
| Chan, NC | 1 |
| Luo, WH | 1 |
| Guo, Y | 1 |
| Huang, JW | 1 |
| Zhang, PD | 1 |
| Olusanya, A | 1 |
| Ogunyemi, A | 1 |
| Arikawe, A | 1 |
| Megbuwawon, T | 1 |
| Amao, O | 1 |
| Johnston, SC | 1 |
| Elm, JJ | 1 |
| Easton, JD | 1 |
| Farrant, M | 1 |
| Barsan, WG | 1 |
| Kim, AS | 1 |
| Lindblad, AS | 1 |
| Palesch, YY | 1 |
| Zurita, KG | 1 |
| Albers, GW | 1 |
| Cucchiara, BL | 1 |
| Kleindorfer, DO | 1 |
| Lutsep, HL | 1 |
| Pearson, C | 1 |
| Sethi, P | 1 |
| Vora, N | 1 |
| Rydberg, DM | 1 |
| Holm, L | 1 |
| Mejyr, S | 1 |
| Loikas, D | 1 |
| Schenck-Gustafsson, K | 1 |
| von Euler, M | 1 |
| Wettermark, B | 1 |
| Malmström, RE | 1 |
| Dahal, UP | 1 |
| Obach, RS | 1 |
| Gilbert, AM | 1 |
| Thushara, RM | 1 |
| Hemshekhar, M | 1 |
| Kemparaju, K | 1 |
| Rangappa, KS | 1 |
| Devaraja, S | 1 |
| Girish, KS | 1 |
| Koziolova, NA | 1 |
| Chen, WC | 1 |
| Li, YD | 1 |
| Chiang, PH | 1 |
| Tsay, FW | 1 |
| Chan, HH | 1 |
| Tsai, WL | 1 |
| Tsai, TJ | 1 |
| Wang, EM | 1 |
| Cheng, JS | 1 |
| Lai, KH | 1 |
| Topaz, M | 1 |
| Lai, K | 1 |
| Dhopeshwarkar, N | 1 |
| Seger, DL | 1 |
| Sa'adon, R | 1 |
| Goss, F | 1 |
| Rozenblum, R | 1 |
| Zhou, L | 1 |
| Noh, Y | 1 |
| Lee, J | 1 |
| Shin, S | 1 |
| Lim, HS | 1 |
| Bae, SK | 1 |
| Oh, E | 1 |
| Kim, GJ | 1 |
| Kim, JH | 1 |
| Lee, S | 1 |
| Yang, L | 1 |
| Lu, YL | 1 |
| Wang, HJ | 1 |
| Zhou, WH | 1 |
| Guidoni, CM | 1 |
| Camargo, HP | 1 |
| Obreli-Neto, PR | 1 |
| Girotto, E | 1 |
| Pereira, LR | 1 |
| Um, SY | 1 |
| Park, JH | 1 |
| Chung, MW | 1 |
| Choi, KH | 1 |
| Lee, HJ | 1 |
| Zhang, P | 1 |
| Li, J | 1 |
| Wu, C | 1 |
| Huang, X | 1 |
| Li, L | 1 |
| Zhang, W | 1 |
| Shen, C | 1 |
| Ciejka, M | 1 |
| Nguyen, K | 1 |
| Bluth, MH | 1 |
| Dubey, E | 1 |
| Elwood, PC | 1 |
| Morgan, G | 1 |
| Galante, J | 1 |
| Chia, JW | 1 |
| Dolwani, S | 1 |
| Graziano, JM | 1 |
| Kelson, M | 1 |
| Lanas, A | 1 |
| Longley, M | 1 |
| Phillips, CJ | 1 |
| Pickering, J | 1 |
| Roberts, SE | 1 |
| Soon, SS | 1 |
| Steward, W | 1 |
| Morris, D | 1 |
| Weightman, AL | 1 |
| Toimela, T | 1 |
| Huttala, O | 1 |
| Sabell, E | 1 |
| Mannerström, M | 1 |
| Sarkanen, JR | 1 |
| Ylikomi, T | 1 |
| Heinonen, T | 1 |
| Payne, CD | 1 |
| Li, YG | 1 |
| Brandt, JT | 1 |
| Jakubowski, JA | 1 |
| Small, DS | 1 |
| Farid, NA | 1 |
| Salazar, DE | 1 |
| Winters, KJ | 1 |
| Spence, JD | 1 |
| Heer, T | 1 |
| Juenger, C | 1 |
| Gitt, AK | 1 |
| Bauer, T | 1 |
| Towae, F | 1 |
| Zahn, R | 1 |
| Senges, J | 1 |
| Zeymer, U | 1 |
| Eisenberg, MJ | 1 |
| Richard, PR | 1 |
| Libersan, D | 1 |
| Filion, KB | 1 |
| Mirabella, F | 1 |
| Francaviglia, B | 1 |
| Capodanno, D | 1 |
| Di Salvo, ME | 1 |
| Galassi, AR | 1 |
| Ussia, GP | 1 |
| Capranzano, P | 1 |
| Tamburino, C | 1 |
| Gorelick, PB | 1 |
| de Leon, J | 1 |
| Kiesel, JL | 1 |
| Fleming, MW | 1 |
| Strobl, B | 1 |
| Yeomans, ND | 1 |
| Hawkey, CJ | 1 |
| Brailsford, W | 1 |
| Naesdal, J | 1 |
| Diedler, J | 1 |
| Ahmed, N | 1 |
| Sykora, M | 1 |
| Uyttenboogaart, M | 1 |
| Overgaard, K | 1 |
| Luijckx, GJ | 1 |
| Soinne, L | 1 |
| Ford, GA | 1 |
| Lees, KR | 1 |
| Wahlgren, N | 1 |
| Ringleb, P | 1 |
| Kramer, E | 1 |
| Hadad, E | 1 |
| Westreich, M | 1 |
| Shalom, A | 1 |
| Crown, N | 1 |
| Mysak, T | 1 |
| Hassan, AE | 1 |
| Zacharatos, H | 1 |
| Vazquez, G | 1 |
| Rodriguez, GJ | 1 |
| Suri, MF | 1 |
| Tummala, RP | 1 |
| Taylor, RA | 1 |
| Qureshi, AI | 1 |
| Gukop, P | 1 |
| Kakouros, N | 1 |
| Hosseini, MT | 1 |
| Valencia, O | 1 |
| Kourliouros, A | 1 |
| Sarsam, M | 1 |
| Chandrasekaran, V | 1 |
| Fried, TR | 1 |
| Tinetti, ME | 1 |
| Towle, V | 1 |
| O'Leary, JR | 1 |
| Iannone, L | 1 |
| Rerkpattanapipat, T | 1 |
| Chiriac, AM | 1 |
| Demoly, P | 1 |
| De Caterina, R | 1 |
| Hylek, EM | 1 |
| Dong, MF | 1 |
| Ma, ZS | 1 |
| Ma, SJ | 1 |
| Chai, SD | 1 |
| Tang, PZ | 1 |
| Yao, DK | 1 |
| Wang, LX | 1 |
| Reidenberg, MM | 1 |
| Patel, V | 1 |
| Fisher, M | 1 |
| Voelker, M | 2 |
| Gessner, U | 1 |
| Wu, CS | 1 |
| Sung, SF | 1 |
| Tong, SH | 1 |
| Ong, CT | 1 |
| Bennett, CL | 1 |
| Starko, KM | 1 |
| Thomsen, HS | 1 |
| Cowper, S | 1 |
| Sartor, O | 1 |
| Macdougall, IC | 1 |
| Qureshi, ZP | 1 |
| Bookstaver, PB | 1 |
| Miller, AD | 1 |
| Norris, LB | 1 |
| Xirasagar, S | 1 |
| Trenery, A | 1 |
| Lopez, I | 1 |
| Kahn, A | 1 |
| Murday, A | 1 |
| Luminari, S | 1 |
| Cournoyer, D | 1 |
| Locatelli, F | 1 |
| Ray, P | 1 |
| Mattison, DR | 1 |
| Baglikov, AN | 1 |
| Rafal'skiĭ, VV | 1 |
| STERNE, TL | 1 |
| CHASSAGNE, P | 1 |
| DEVAUX, JP | 1 |
| BURNS, JJ | 1 |
| CUCINELL, SA | 1 |
| KOSTER, R | 1 |
| CONNEY, AH | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial[NCT00991029] | Phase 3 | 4,881 participants (Actual) | Interventional | 2010-05-28 | Terminated (stopped due to The trial was halted by the DSMB.) | ||
| PPD Trial Pilot Study: Plavix, Prasugrel and Drug Eluting Stents[NCT01103843] | 1,000 participants (Anticipated) | Interventional | 2010-04-30 | Recruiting | |||
| SPIDER: A Structured Process Informed by Data, Evidence and Research - A Research and Quality Improvement Collaboration Supporting Practices in Improving Care for Complex Elderly Patients[NCT03689049] | 104 participants (Anticipated) | Interventional | 2018-03-26 | Enrolling by invitation | |||
| Pharmacist-led Intervention to Reduce Potentially Inappropriate Prescription in Elderly and Polypharmacy Patients at Primary Care Setting (PHARM-PC) Cluster Randomized Trial[NCT02224833] | 549 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| Prevention of Adverse Drug Events (ADEs) in Hospitalised Older Patients Using STOPP/START Criteria[NCT01467050] | Phase 4 | 732 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| A Three Month, Open-label, Single-arm Trial Evaluating the Safety and Pharmacokinetics of Oral Lithium in Patients Diagnosed With Chronic Spinal Cord Injury[NCT00431171] | Phase 1 | 20 participants (Anticipated) | Interventional | 2007-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Secondary efficacy outcome: Number of participants with ischemic stroke, myocardial infarction, death from ischemic vascular causes, or major hemorrhage (NCT00991029)
Timeframe: Up to 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Clopidogrel | 141 |
| Placebo | 167 |
Primary efficacy outcome: Number of Participants with Ischemic Stroke, Myocardial Infarction, or Death From Ischemic Vascular Causes (NCT00991029)
Timeframe: Up to 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Clopidogrel | 121 |
| Placebo | 160 |
Other safety outcome: Number of Participants with Death from any cause (NCT00991029)
Timeframe: up to 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Clopidogrel | 18 |
| Placebo | 12 |
Secondary efficacy outcome: Number of participants with Death from ischemic vascular causes (NCT00991029)
Timeframe: Up to 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Clopidogrel | 6 |
| Placebo | 4 |
Other safety outcome: Number of participants with Hemorrhagic stroke (NCT00991029)
Timeframe: up to 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Clopidogrel | 5 |
| Placebo | 3 |
Secondary efficacy outcome: Number of participants with Ischemic or hemorrhagic stroke (NCT00991029)
Timeframe: Up to 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Clopidogrel | 116 |
| Placebo | 156 |
Secondary efficacy outcome:Number of participants with Ischemic stroke (NCT00991029)
Timeframe: Up to 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Clopidogrel | 112 |
| Placebo | 155 |
Primary safety outcome: Number of Participants with major hemorrhage (NCT00991029)
Timeframe: Up to 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Clopidogrel | 23 |
| Placebo | 10 |
Other safety outcome: Number of Participants with Major hemorrhage other than intracranial hemorrhage (NCT00991029)
Timeframe: up to 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Clopidogrel | 17 |
| Placebo | 7 |
Other safety outcome:Number of Participants with Minor hemorrhage (NCT00991029)
Timeframe: up to 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Clopidogrel | 40 |
| Placebo | 13 |
Secondary efficacy outcome: Number of participants with Myocardial infarction (NCT00991029)
Timeframe: Up to 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Clopidogrel | 10 |
| Placebo | 7 |
Other safety outcome: Number of participants with other symptomatic intracranial hemorrhage (NCT00991029)
Timeframe: up to 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Clopidogrel | 2 |
| Placebo | 0 |
Other safety outcome: Number of participants with Symptomatic intracerebral hemorrhage (NCT00991029)
Timeframe: up to 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Clopidogrel | 2 |
| Placebo | 2 |
36 reviews available for aspirin and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Drug interactions with apixaban: A systematic review of the literature and an analysis of VigiBase, the World Health Organization database of spontaneous safety reports.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Area Under Curve; Aspirin; | 2020 |
[Management of the bleeding risk associated with antiplatelet agents].
Topics: Adenosine; Aspirin; Clopidogrel; Drug-Related Side Effects and Adverse Reactions; Hemorrhage; Humans | 2017 |
Traditional Chinese medicine: herb-drug interactions with aspirin.
Topics: Aspirin; Carthamus; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Herb-Dru | 2018 |
Efficacy and safety of triple therapy versus dual antiplatelet therapy in patients with atrial fibrillation undergoing coronary stenting: A meta-analysis.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Drug Combinations; Drug-Related Side Effects and Adverse | 2018 |
Long-Term Management of Venous Thromboembolism: Lessons from EINSTEIN CHOICE and Other Extension Trials.
Topics: Anticoagulants; Aspirin; Canada; Clinical Trials as Topic; Drug-Related Side Effects and Adverse Rea | 2019 |
Therapeutic drug-induced platelet apoptosis: an overlooked issue in pharmacotoxicology.
Topics: Apoptosis; Aspirin; Blood Platelets; Cisplatin; Drug-Related Side Effects and Adverse Reactions; Hum | 2014 |
[Antiplatelet therapy in atherosclerosis of various localizations: acute and stable States].
Topics: Acute Coronary Syndrome; Aspirin; Atherosclerosis; Drug Therapy, Combination; Drug-Related Side Effe | 2014 |
Efficacy and safety of aspirin combined with warfarin after acute coronary syndrome : A meta-analysis.
Topics: Acute Coronary Syndrome; Adult; Aged; Anticoagulants; Aspirin; Causality; Comorbidity; Dose-Response | 2017 |
Drug Toxicities of Common Analgesic Medications in the Emergency Department.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2016 |
Systematic Review and Meta-Analysis of Randomised Trials to Ascertain Fatal Gastrointestinal Bleeding Events Attributable to Preventive Low-Dose Aspirin: No Evidence of Increased Risk.
Topics: Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastrointestinal Hemorrhage; Humans; Myoca | 2016 |
Polypill: for Pollyanna.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Drug Therapy; | 2008 |
Safety of short-term discontinuation of antiplatelet therapy in patients with drug-eluting stents.
Topics: Aged; Aspirin; Case-Control Studies; Data Collection; Drug-Eluting Stents; Drug-Related Side Effects | 2009 |
Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Dose-Response Relationship, Drug; Drug- | 2009 |
Safety of fixed-dose aspirin-extended-release dipyridamole in patients with ischemic heart disease.
Topics: Aspirin; Aspirin, Dipyridamole Drug Combination; Dipyridamole; Drug Combinations; Drug-Related Side | 2010 |
Drug provocation tests in hypersensitivity drug reactions.
Topics: Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; beta-Lactams; Contrast Media; | 2011 |
Stroke prevention in atrial fibrillation: current status and near-future directions.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antithrombins; Aspirin; Atrial Fibrillation; Contrain | 2011 |
Gastrointestinal effects of the addition of ascorbic acid to aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Ascorbic Acid; Aspirin; Drug-Related Side Eff | 2012 |
Linking drugs to obscure illnesses: lessons from pure red cell aplasia, nephrogenic systemic fibrosis, and Reye's syndrome. a report from the Southern Network on Adverse Reactions (SONAR).
Topics: Aspirin; Drug-Related Side Effects and Adverse Reactions; Erythropoietin; Female; Gadolinium; Humans | 2012 |
Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Child, Preschool; Com | 2006 |
Efficacy and safety of 1,000 mg effervescent aspirin: individual patient data meta-analysis of three trials in migraine headache and migraine accompanying symptoms.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relatio | 2007 |
[Drug-induced pulmonary edema].
Topics: Amiodarone; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; | 2007 |
Over-the-counter and iatrogenically induced psychoses: a review of the literature.
Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Appetite Depressants; Aspirin; Cimetidine; Disulfir | 1984 |
[Drug-induced lesions in the upper gastrointestinal tract].
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Arthritis, Rheumatoid; Aspirin; Cheilitis; Drug-Rela | 1984 |
Clinical studies of drug effects in humans.
Topics: Aspirin; Case-Control Studies; Cohort Studies; Drug Therapy; Drug-Related Side Effects and Adverse R | 1996 |
[Pulmonary toxicity caused by drugs].
Topics: Acute Disease; Amiodarone; Anti-Arrhythmia Agents; Anti-Infective Agents, Urinary; Anti-Inflammatory | 1999 |
Drug-induced pulmonary disease.
Topics: Adrenergic beta-Antagonists; Adverse Drug Reaction Reporting Systems; Aerosols; Amiodarone; Angioten | 1992 |
[Drugs in Poland: a review of literature on the symptoms of side effects].
Topics: Aminopyrine; Anaphylaxis; Anti-Bacterial Agents; Aspirin; Barbiturates; Chloramphenicol; Contrast Me | 1985 |
Complications in patients on therapeutic drugs.
Topics: Adrenal Cortex Hormones; Anemia, Aplastic; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Catech | 1986 |
Drug-vitamin interaction.
Topics: Anticonvulsants; Ascorbic Acid; Ascorbic Acid Deficiency; Aspirin; Drug Interactions; Drug-Related S | 1985 |
Adverse hematologic effects of drugs.
Topics: Anemia, Hemolytic; Anemia, Macrocytic; Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents | 1972 |
Potential environmental chemical hazards. I. Drugs.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Analgesics; Animals; Aspirin; Carcinogens; Drug-Rela | 1972 |
Present status of drugs as teratogens in man.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Anti-Bacterial Agents; Anticonvulsants; Antiemetics; | 1973 |
Allergy in adverse drug reactions.
Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Aged; Anemia, Aplastic; Anemia, Hemolytic; Anemia, | 1973 |
[Drugs and parameters in the laboratory medicine].
Topics: Aminosalicylic Acids; Aspirin; Blood Cell Count; Chlorpromazine; Chlorpropamide; Circadian Rhythm; C | 1973 |
[Side effects of drugs and their causes].
Topics: Aspirin; Diet; Drug Hypersensitivity; Drug Tolerance; Drug-Related Side Effects and Adverse Reaction | 1969 |
[Present position of the toxicology of drugs].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Amantadine; Aminopterin; Animals; Animals, Newbo | 1970 |
5 trials available for aspirin and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Time Course for Benefit and Risk of Clopidogrel and Aspirin After Acute Transient Ischemic Attack and Minor Ischemic Stroke.
Topics: Acute Disease; Aspirin; Clinical Protocols; Clopidogrel; Drug Therapy, Combination; Drug-Related Sid | 2019 |
Switching directly to prasugrel from clopidogrel results in greater inhibition of platelet aggregation in aspirin-treated subjects.
Topics: Adenosine Diphosphate; Adult; Aspirin; Clopidogrel; Drug-Related Side Effects and Adverse Reactions; | 2008 |
Practice considerations of early aspirin administration following coronary artery bypass surgery.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Comorbidity; Coronary Artery Bypass; Drug-Re | 2011 |
Anticoagulation therapy with combined low dose aspirin and warfarin following mechanical heart valve replacement.
Topics: Adult; Anticoagulants; Aspirin; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Rea | 2011 |
Measurement of side effects of drugs.
Topics: Analgesics; Anti-Inflammatory Agents; Aspirin; Deafness; Drug-Related Side Effects and Adverse React | 1974 |
107 other studies available for aspirin and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Adverse event profiles of microscopic colitis in the Japanese Adverse Drug Event Report (JADER) database.
Topics: Adverse Drug Reaction Reporting Systems; Aspirin; Colitis, Microscopic; Drug-Related Side Effects an | 2022 |
Symptom Control of Patients With Chronic Rhinosinusitis With Nasal Polyps Under Maintenance Therapy With Daily Acetylsalicylic Acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma, Aspirin-Induced; Chronic Disease; Desensit | 2020 |
Comparison of Hemorrhagic Risk between Prasugrel and Clopidogrel: a Retrospective Study using Adverse Drug Event Reporting Databases.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clinical Trials, Phase II | 2020 |
Clustering-Based Hybrid Approach for Identifying Quantitative Multidimensional Associations Between Patient Attributes, Drugs and Adverse Drug Reactions.
Topics: Algorithms; Aspirin; Cluster Analysis; Data Mining; Drug-Related Side Effects and Adverse Reactions; | 2020 |
Long-term Clinical Outcomes of Aspirin Desensitization With Continuous Daily Aspirin Therapy in Aspirin-exacerbated Respiratory Disease.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma, Aspirin-In | 2018 |
Evaluation of Potential Drug-Drug Interactions With Direct Oral Anticoagulants in a Large Urban Hospital.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Dabigatran; Drug Comb | 2020 |
Aspirin use and the risk of malignant melanoma.
Topics: Aspirin; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; Humans; Male; Melanoma; Sk | 2019 |
Pharmacogenetic and clinical predictors of response to clopidogrel plus aspirin after acute coronary syndrome in Egyptians.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combina | 2018 |
Drug-Induced Fixed Urticaria as a Presentation of NSAID Intolerance.
Topics: Administration, Oral; Allergens; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Hypersensiti | 2019 |
Ascertainment of Aspirin Exposure Using Structured and Unstructured Large-scale Electronic Health Record Data.
Topics: Adult; Aged; Aspirin; Colonoscopy; Data Collection; Databases, Factual; Drug Prescriptions; Drug-Rel | 2019 |
Do Statins Have a Positive Impact on Patients with Coronary Microvascular Dysfunction on Long-Term Clinical Outcome? A Large Retrospective Cohort Study.
Topics: Aged; Aspirin; Coronary Angiography; Coronary Artery Disease; Diabetes Mellitus; Drug-Related Side E | 2019 |
Inappropriate drug use in the elderly outpatient population in a West-African metropolitan community
.
Topics: Africa, Western; Aged; Aspirin; Drug-Related Side Effects and Adverse Reactions; Humans; Hypertensio | 2019 |
Sex differences in spontaneous reports on adverse bleeding events of antithrombotic treatment.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aspirin; Child; Child, Preschool; | 2014 |
Benchmarking in vitro covalent binding burden as a tool to assess potential toxicity caused by nonspecific covalent binding of covalent drugs.
Topics: Adamantane; Aspirin; Carbon Radioisotopes; Cells, Cultured; Drug-Related Side Effects and Adverse Re | 2013 |
Comparison of proton pump inhibitor and histamine-2 receptor antagonist in the prevention of recurrent peptic ulcers/erosions in long-term low-dose aspirin users: a retrospective cohort study.
Topics: Aged; Aged, 80 and over; Aspirin; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; F | 2014 |
Clinicians' Reports in Electronic Health Records Versus Patients' Concerns in Social Media: A Pilot Study of Adverse Drug Reactions of Aspirin and Atorvastatin.
Topics: Adverse Drug Reaction Reporting Systems; Aspirin; Atorvastatin; Drug-Related Side Effects and Advers | 2016 |
Antiplatelet Therapy of Cilostazol or Sarpogrelate with Aspirin and Clopidogrel after Percutaneous Coronary Intervention: A Retrospective Cohort Study Using the Korean National Health Insurance Claim Database.
Topics: Aspirin; Cilostazol; Clopidogrel; Drug-Related Side Effects and Adverse Reactions; Hemorrhage; Human | 2016 |
[Pharmacogenomics study of 620 whole-exome sequencing: focusing on aspirin application].
Topics: Asian People; Aspirin; Child; Drug-Related Side Effects and Adverse Reactions; Exome; Gene Frequency | 2016 |
Study of warfarin utilization in hospitalized patients: analysis of possible drug interactions.
Topics: Adult; Aged; Amiodarone; Anticoagulants; Aspirin; Brazil; Cross-Sectional Studies; Drug Interactions | 2016 |
(1)H-Nuclear magnetic resonance-based metabolic profiling of nonsteroidal anti-inflammatory drug-induced adverse effects in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; D | 2016 |
Intra-laboratory validated human cell-based in vitro vasculogenesis/angiogenesis test with serum-free medium.
Topics: 2-Methoxyestradiol; Adipose Tissue; Aspirin; Cells, Cultured; Culture Media; Drug-Related Side Effec | 2017 |
Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: Recommendation Statement.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Colorectal N | 2016 |
Efficacy and safety of optimized antithrombotic therapy with aspirin, clopidogrel and enoxaparin in patients with non-ST segment elevation acute coronary syndromes in clinical practice.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Drug Evaluation; Drug Therapy, Combination; Dru | 2009 |
Treatment of multilesion coronary artery disease with simultaneous drug-eluting and bare-metal stent implantation: clinical follow up and angiographic mid-term results.
Topics: Abciximab; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; A | 2009 |
Cerebral microbleeds: evidence of heightened risk associated with aspirin use.
Topics: Aspirin; Biomarkers; Cardiovascular Diseases; Cerebral Arteries; Cerebral Hemorrhage; Cohort Studies | 2009 |
Valproic acid toxicity associated with low dose of aspirin and low total valproic acid levels: a case report.
Topics: Aspirin; Dose-Response Relationship, Drug; Drug Interactions; Drug-Related Side Effects and Adverse | 2009 |
Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Cerebral Hemorrh | 2010 |
Lack of complications in skin surgery of patients receiving clopidogrel as compared with patients taking aspirin, warfarin, and controls.
Topics: Aged; Anticoagulants; Aspirin; Case-Control Studies; Clopidogrel; Dermatologic Surgical Procedures; | 2010 |
Low risk of intracranial and systemic hemorrhages in patients on dual antiplatelet treatment beyond 1 month following neuroendovascular angioplasty and/or stent placement.
Topics: Angioplasty; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Combined Modality Therapy; Comorbidity; | 2012 |
Effects of benefits and harms on older persons' willingness to take medication for primary cardiovascular prevention.
Topics: Aged; Aged, 80 and over; Aspirin; Cardiotonic Agents; Cardiovascular Diseases; Drug-Related Side Eff | 2011 |
Drug discontinuation effects are part of the pharmacology of a drug.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Aspirin; Awards and Prizes; Cardiovascular Age | 2011 |
Multiple cerebral infarctions related to famotidine-induced eosinophilia.
Topics: Acarbose; Adrenergic alpha-1 Receptor Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulc | 2012 |
[The value of compliance during chronic administration of acetylsalicylic acid in patients with acute coronary syndrome: results of the study FORPOST].
Topics: Abdominal Pain; Acute Coronary Syndrome; Aged; Aspirin; Drug-Related Side Effects and Adverse Reacti | 2012 |
Adverse drug reaction update.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bupropion; Chemical and Drug Induced Liver Injury; | 2002 |
Exchange transfusion for aspirin poisoning.
Topics: Aminosalicylic Acid; Aspirin; Blood Transfusion; Drug-Related Side Effects and Adverse Reactions; Ex | 1959 |
[Acute intoxication caused by aspirin].
Topics: Aspirin; Drug-Related Side Effects and Adverse Reactions; Psychoses, Substance-Induced | 1961 |
APPLICATION OF DRUG METABOLISM TO DRUG TOXICITY STUDIES.
Topics: Aspirin; Blood; Chromatography; Dicumarol; Diphenhydramine; Dogs; Drug-Related Side Effects and Adve | 1965 |
ACUTE SALICYLATE INTOXICATION: EFFECT ON THE DIRECT EOSINOPHIL COUNT.
Topics: Aspirin; Drug-Related Side Effects and Adverse Reactions; Eosinophils; Leukocyte Count; Poisoning; P | 1965 |
Accidental chemical poisonings. Triflupromazine hydrochloride, aspirin, and phosphorus poisonings.
Topics: Aspirin; Drug-Related Side Effects and Adverse Reactions; Phosphorus; Phosphorus, Dietary; Tranquili | 1962 |
Drug-induced hepatotoxicity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Injury; Child; Dru | 2003 |
Adverse drug reactions in children requiring hospital admission.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Bacterial Agents; Aspirin; Child, Preschool; Developin | 2003 |
[The problems of multiple-chemical sensitivity patients in using medicinal drugs].
Topics: Adult; Aspirin; Caffeine; Contraindications; Drug Hypersensitivity; Drug-Related Side Effects and Ad | 2004 |
Drug-induced upper gastrointestinal disorders requiring hospitalization: a five-year study in a South Indian hospital.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug-Related Side Effects a | 2004 |
Suppressing the scourge of AMI.
Topics: Adrenergic beta-Antagonists; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitor | 2006 |
Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure.
Topics: Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Ste | 2006 |
Patients' knowledge of adverse reactions to current medications.
Topics: Acute Disease; Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulant | 2006 |
Drug-related problems in general practice: results from a development project in Denmark.
Topics: Aged; Aspirin; Attitude of Health Personnel; Community Pharmacy Services; Cooperative Behavior; Denm | 2006 |
Clinically important drug-disease interactions and their prevalence in older adults.
Topics: Aged; Aspirin; Calcium Channel Blockers; Chronic Disease; Drug-Related Side Effects and Adverse Reac | 2006 |
The trouble with making combination drugs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-HIV Agents; Aspirin; Chemistry, Pharmaceutical; Drug | 2006 |
Prevalence and patient awareness of selected potential drug interactions with self-medication.
Topics: Administration, Oral; Adult; Aged; Anticoagulants; Aspirin; Clinical Pharmacy Information Systems; D | 2007 |
Admissions to a medical intensive care unit related to adverse drug reactions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Drug-Related Side Effects and Adverse | 2007 |
[The Brazilian pharmaceutical market and the North American war effort].
Topics: Analgesics; Antimalarials; Aspirin; Brazil; Culture; Drug and Narcotic Control; Drug Delivery System | 2002 |
STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation.
Topics: Abbreviations as Topic; Age Factors; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspi | 2008 |
STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation.
Topics: Abbreviations as Topic; Age Factors; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspi | 2008 |
STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation.
Topics: Abbreviations as Topic; Age Factors; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspi | 2008 |
STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation.
Topics: Abbreviations as Topic; Age Factors; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspi | 2008 |
Management of adverse drug reactions.
Topics: Anaphylaxis; Antineoplastic Agents; Aspirin; Bronchial Spasm; Drug Hypersensitivity; Drug-Related Si | 1984 |
[Drug-induced disturbances of the coagulation system (author's transl)].
Topics: Adrenal Cortex Hormones; Anticoagulants; Aspirin; Blood Coagulation; Contraceptives, Oral, Hormonal; | 1980 |
Gastrointestinal consequences of treatment with drugs in elderly patients.
Topics: Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Digestive System Physiological Phenom | 1982 |
Record linkage for drug monitoring.
Topics: Aged; Aspirin; Cerebral Hemorrhage; Computers; Delivery, Obstetric; Diarrhea; Digoxin; Drug-Related | 1981 |
Acetaminophen, some other drugs, some diseases and the risk of transitional cell carcinoma. A population-based case-control study.
Topics: Acetaminophen; Age Factors; Analgesics; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Aspir | 1995 |
Adverse drug reactions resulting in hospital admission.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Analgesics; Ant | 1994 |
Coverage by the news media of the benefits and risks of medications.
Topics: Alendronate; Anticholesteremic Agents; Aspirin; Biomedical Research; Cardiovascular Diseases; Confli | 2000 |
Shaking the world of gene therapy.
Topics: Aspirin; California; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Genetic Therapy; | 2000 |
Prediction of potential toxicity and side effect protein targets of a small molecule by a ligand-protein inverse docking approach.
Topics: Ascorbic Acid; Aspirin; Computer Simulation; Drug-Related Side Effects and Adverse Reactions; Gentam | 2001 |
[Infantile thrombopenias and drugs].
Topics: Anti-Bacterial Agents; Antimalarials; Aspirin; Child; Child, Preschool; Drug-Related Side Effects an | 1978 |
Drug-induced anaphylaxis, convulsions, deafness, and extrapyramidal symptoms.
Topics: Anaphylaxis; Anti-Bacterial Agents; Aspirin; Basal Ganglia Diseases; Deafness; Drug-Related Side Eff | 1977 |
Rhinitis medicamentosa.
Topics: Antihypertensive Agents; Aspirin; Cocaine; Drug-Related Side Effects and Adverse Reactions; Estrogen | 1979 |
Behavioral side effects of medical drugs.
Topics: Adrenal Cortex Hormones; Aged; Antihypertensive Agents; Antitubercular Agents; Aspirin; Behavior; Ca | 1979 |
[Gastrointestinal hemorrhages as a consequence of the side effects of drug substances].
Topics: Aspirin; Blood Volume; Drug-Related Side Effects and Adverse Reactions; Female; Gastrointestinal Hem | 1977 |
Gastric mucosal injury from common drugs.
Topics: Adrenal Cortex Hormones; Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastric Mucosa; G | 1978 |
Ototoxicity of commonly used pharmaceutical preparations.
Topics: Adolescent; Adult; Ampicillin; Antihypertensive Agents; Antineoplastic Agents; Aspirin; Child; Chlor | 1979 |
Ototoxic agents.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Aspirin; Child; Drug-Related Side Effects and Adver | 1978 |
[Medicines in young children].
Topics: Aspirin; Child; Digoxin; Drug-Related Side Effects and Adverse Reactions; Humans; Iron; Penicillins; | 1978 |
[Effect of drug therapy during pregnancy on the clotting potential of the newborn].
Topics: Aspirin; Blood Coagulation Disorders; Drug-Related Side Effects and Adverse Reactions; Female; Hemos | 1977 |
[Gastrointestinal hemorrhage caused by side effect of drugs].
Topics: Adult; Aged; Aspirin; Butadienes; Drug-Related Side Effects and Adverse Reactions; Female; Humans; I | 1976 |
Adverse interaction of drugs.
Topics: Aged; Antacids; Aspirin; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Ethanol | 1976 |
[Serious complications of current treatments].
Topics: Acidosis; Adolescent; Aged; Alcoholism; Antihypertensive Agents; Aspirin; Diuretics; Drug-Related Si | 1975 |
A clinical look at the problem of drugs in pregnancy and their effect on the fetus.
Topics: Abnormalities, Drug-Induced; Anesthesia, Obstetrical; Aspirin; Drug-Related Side Effects and Adverse | 1975 |
A practical classification of untoward drug effects.
Topics: Aspirin; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Humans; Penicillins | 1975 |
Adverse drug reactions. A critical review.
Topics: Anti-Bacterial Agents; Antihypertensive Agents; Aspirin; Costs and Cost Analysis; Digitalis Glycosid | 1975 |
Occurence of peptic ulcer disease in Copenhagen males age 40-59. Life incidence and one-year incidence correlated to environmental factors, life habits, physical factors, and concomitant disease.
Topics: Adult; Alcohol Drinking; Aspirin; Denmark; Drug-Related Side Effects and Adverse Reactions; Follow-U | 1976 |
Drugs and gastric damage.
Topics: Adrenal Cortex Hormones; Aspirin; Buffers; Caffeine; Drug Compounding; Drug-Related Side Effects and | 1976 |
Drug-induced illness as a cause for admission to a community hospital.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug- | 1989 |
Drug use before hospital admission in Zimbabwe.
Topics: Analgesics; Anti-Bacterial Agents; Aspirin; Chloroquine; Drug Therapy; Drug-Related Side Effects and | 1988 |
[Digestive hemorrhages caused by drugs].
Topics: Anti-Inflammatory Agents; Anticoagulants; Aspirin; Drug-Related Side Effects and Adverse Reactions; | 1973 |
Lung disease caused by drugs.
Topics: Aspirin; Asthma; Contraceptives, Oral; Drug-Related Side Effects and Adverse Reactions; Eosinophilia | 1969 |
Drugs--remarkably nontoxic.
Topics: Adult; Aspirin; Boston; Digoxin; Drug Evaluation; Drug Therapy; Drug Utilization; Drug-Related Side | 1974 |
[Deafness as a result of the use of drugs].
Topics: Anti-Bacterial Agents; Aspirin; Deafness; Drug-Related Side Effects and Adverse Reactions; Ethacryni | 1974 |
Editorial: The pursuit of a chimera.
Topics: Acetaminophen; Animals; Aspirin; Barbiturates; Chloroform; Dogs; Drug-Related Side Effects and Adver | 1974 |
[Medicamentous agranulocytosis as a manifestation of drug induced disease].
Topics: Adult; Agranulocytosis; Aminopyrine; Aspirin; Chloramphenicol; Drug-Related Side Effects and Adverse | 1974 |
Developments in drug therapy.
Topics: Antiparkinson Agents; Appetite Depressants; Aspirin; Biopharmaceutics; Drug-Related Side Effects and | 1973 |
[Blood coagulation disorders of a toxic (alcoholism, drugs, poisoning) or iatrogenic (anticoagulants) nature].
Topics: Alcoholic Intoxication; Analgesics; Anticoagulants; Aspirin; Blood Coagulation Disorders; Blood Coag | 1972 |
[Gastric erosions and ulcerations in gastritis caused by drugs].
Topics: Aminopyrine; Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastritis; Gastroscopy; Gluco | 1972 |
Adverse reaction profiles of drug eruptions.
Topics: Ampicillin; Analgesics; Aspirin; Chlorpromazine; Drug-Related Side Effects and Adverse Reactions; Er | 1972 |
Drug-induced deafness.
Topics: Adult; Anti-Bacterial Agents; Aspirin; Deafness; Drug-Related Side Effects and Adverse Reactions; Et | 1973 |
A pharmacist-based study of the epidemiology of adverse drug reactions in pediatric medicine patients.
Topics: Age Factors; Aspirin; Cardiovascular System; Child; Computers; Drug-Related Side Effects and Adverse | 1973 |
Death after taking medicaments.
Topics: Adrenal Cortex Hormones; Analgesics; Anti-Bacterial Agents; Antidepressive Agents; Aspirin; Chlorpro | 1974 |
Recognizing and avoiding adverse gastrointestinal effects of drugs.
Topics: Aged; Antacids; Aspirin; Colon; Digestive System; Drug Antagonism; Drug Interactions; Drug-Related S | 1974 |
100-day LD 50 index of chronic toxicity.
Topics: Acetaminophen; Administration, Oral; Animals; Aspirin; Atropine; Caffeine; DDT; Drug-Related Side Ef | 1971 |
Studies on the epidemiology of adverse drug reactions. VI. Utilization and interactions of prescription and nonprescription drugs in outpatients.
Topics: Adult; Aspirin; Drug Interactions; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactio | 1971 |
Drugs and children.
Topics: Aminophylline; Aspirin; Atropine; Cardiomyopathies; Cataract; Child, Preschool; Chloramphenicol; Chl | 1968 |
[Iatrogenic hemorrhage].
Topics: Anticoagulants; Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastrointestinal Hemorrhag | 1968 |
[Digestive disorders from drug origin. I. Gastrointestinal lesions].
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anticoagulants; Aspirin; C | 1971 |
Studies on the detection of adverse drug reactions in the newborn. I. Fetal exposure to maternal medication.
Topics: Antacids; Aspirin; Drug-Related Side Effects and Adverse Reactions; Female; Gestational Age; Humans; | 1970 |
The other edge.
Topics: Aged; Aspirin; Atropine; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Imipramine | 1970 |