aspirin has been researched along with Down Syndrome in 7 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Some are beginning to broaden prenatal screening to include pregnancy complications such as pre-eclampsia that can be prevented using soluble low-dose aspirin treatment started before 16 weeks of gestation." | 4.93 | Development of prenatal screening--A historical overview. ( Cuckle, H; Maymon, R, 2016) |
| "Standard treatment of Kawasaki disease was administered (immunoglobulins, acetylsalicylic acid) and orciprenalin due to described cardiac block." | 1.33 | [Late recognition of Kawasaki disease--difficulties in diagnosis]. ( Berdej-Szczot, E; Giec-Fuglewicz, G; Gołba, E; Kohut, J; Smoleńska-Petelenz, J; Szydłowski, L, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cuckle, H | 1 |
| Maymon, R | 1 |
| Butera, G | 1 |
| Gaio, G | 1 |
| Carminati, M | 1 |
| Kohut, J | 1 |
| Gołba, E | 1 |
| Giec-Fuglewicz, G | 1 |
| Smoleńska-Petelenz, J | 1 |
| Berdej-Szczot, E | 1 |
| Szydłowski, L | 1 |
| Takasugi, H | 1 |
| Maemoto, T | 1 |
| Kitazawa, K | 1 |
| Honda, A | 1 |
| Ebadi, MS | 1 |
| Kugel, RB | 1 |
| Sahud, MA | 1 |
| Alderson, MR | 1 |
2 reviews available for aspirin and Down Syndrome
| Article | Year |
|---|---|
Development of prenatal screening--A historical overview.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Cell-Free System; DNA; Down Syndrome; | 2016 |
Platelet disorders: a review of disturbances in adhesion, aggregation, and release reaction.
Topics: Adenosine Diphosphate; Afibrinogenemia; Anemia; Aspirin; Blood Platelet Disorders; Connective Tissue | 1972 |
1 trial available for aspirin and Down Syndrome
| Article | Year |
|---|---|
Are clinical trials required.
Topics: Aspirin; Clinical Trials as Topic; Common Cold; Diphtheria Toxoid; Down Syndrome; Drug Evaluation; H | 1974 |
4 other studies available for aspirin and Down Syndrome
| Article | Year |
|---|---|
Is steroid therapy enough to reverse complete atrioventricular block after percutaneous perimembranous ventricular septal defect closure?
Topics: Anti-Inflammatory Agents; Aspirin; Atrioventricular Block; Cardiac Catheterization; Cardiac Pacing, | 2009 |
[Late recognition of Kawasaki disease--difficulties in diagnosis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bradycardia; Child; Coronary Aneurysm; Coronary Ve | 2006 |
[A case of Down syndrome with moyamoya syndrome presenting extensive multiple cerebral infarction during measles infection].
Topics: Aspirin; Cerebral Infarction; Child, Preschool; Down Syndrome; Humans; Male; Measles; Moyamoya Disea | 2000 |
Alteration in metabolism of acetylsalicylic acid in children with Down's syndrome: decreased plasma binding and formation of salicyluric acid.
Topics: Aspirin; Child; Child, Preschool; Down Syndrome; Erythrocytes; Female; Humans; Male; Pharmacogenetic | 1970 |