aspirin has been researched along with Disease Models, Animal in 786 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our results demonstrated that the combination of quercetin and aspirin exerted significantly stronger effects than aspirin alone on decreasing systolic blood pressure and proteinuria, reducing pro-inflammatory cytokine production, and inhibiting M1-type decidual macrophages polarization in an LPS-induced rat model of preeclampsia." | 8.31 | Natural Flavonoid Quercetin Enhances the Anti-inflammatory Effects of Aspirin in a Preeclampsia-like Rat Model Induced by Lipopolysaccharide. ( Chen, D; Ding, J; Liu, A; Yang, S, 2023) |
| "Aspirin induced TTS can protect from cisplatin-induced ototoxicity." | 8.31 | The protective effect of aspirin-induced temporary threshold shift in an animal model of cisplatin-related ototoxicity. ( Attias, J; Barkan, N; Hikri, E; Hilly, O; Mizrachi, A; Shivatzki, S; Tzelnick, S; Yosefof, E, 2023) |
| " To evaluate the analgesic effects of AC, 4 different pain models including hot plate assay, acetic acid writhing assay, formalin and CFA induced pain models were adopted in this study." | 8.02 | Comparison of analgesic activities of aconitine in different mice pain models. ( Chen, J; Deng, J; Feng, Q; Han, J; Huang, Q; Leung, EL; Liu, Z; Lu, L; Qi, X; Wang, D; Wang, Y; Zhang, Y, 2021) |
| "The protective effect of aspirin against myocardial hypertrophy (MH) was studied." | 8.02 | The Protective Effect of Aspirin against Myocardial Hypertrophy in Rats. ( Fan, X; Liu, J; Ma, X; Wei, M; Wu, X; Xue, M; Zhang, H, 2021) |
| "Beside its therapeutic role in the thrombotic vascular events, Clopidogrel confers significant protection against ischemic myocardial injury by counteracting the platelet-mediated inflammation and oxidative stress associated with HFD-C consumption in animals." | 7.96 | Clopidogrel Prophylaxis Abates Myocardial Ischemic Injury and Inhibits the Hyperlipidemia-Inflammation Loop in Hypercholestrolemic Mice. ( Korish, AA, 2020) |
| "We assessed the effects of ticagrelor, aspirin and prasugrel, started 7days after myocardial ischemia-reperfusion injury on remodeling, inflammation and fibrosis in the rat." | 7.91 | Ticagrelor Improves Remodeling, Reduces Apoptosis, Inflammation and Fibrosis and Increases the Number of Progenitor Stem Cells After Myocardial Infarction in a Rat Model of Ischemia Reperfusion. ( Birnbaum, Y; Chen, H; Nylander, S; Sampaio, LC; Tran, D; Ye, Y, 2019) |
| "Present study was planned to estimate the gastroprotective activity of Euphorbia prostrata plant against aspirin induced gastric ulcers in male adult albino rabbits." | 7.91 | Gastroprotective and antioxidant potential of Euphorbia prostrata against aspirin induced gastric ulcers in rabbits. ( Ahmad, M; Aslam, B; Mohsin, M; Muhammad, F; Raza, A, 2019) |
| "Our study reveals a novel mechanism by which aspirin alleviates pressure overload-induced cardiac interstitial fibrosis in TAC mice by suppressing the p-Erk1/2 and p-Akt/β-catenin signalling pathways." | 7.88 | Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways. ( E, X; Feng, Y; Gitau, SC; Li, T; Li, X; Liang, H; Liu, X; Qian, M; QiLi, M; Shan, H; Shen, Z; Wang, G; Xu, B; Zhang, Y; Zhao, D, 2018) |
| "Antipsychotic drugs plus aspirin (acetylsalicylic acid), which targets prostaglandin-endoperoxide synthase 1 (PTGS1: COX1), improved therapeutic outcomes when treating schizophrenia." | 7.88 | Studies on Prostaglandin-Endoperoxide Synthase 1: Lower Levels in Schizophrenia and After Treatment with Antipsychotic Drugs in Conjunction with Aspirin. ( Dean, B; Gibbons, A; Gogos, A; Scarr, E; Thomas, E; Udawela, M, 2018) |
| "The consequences of using aspirin (ASA) for the pathogenesis of Chagas disease are unclear." | 7.85 | Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease. ( Araújo, EJ; Massocatto, CL; Moreira, NM; Muniz, E; Pinge-Filho, P; Rossi, RM; Sant'Ana, DM, 2017) |
| "Metformin can induce breast cancer (BC) cell apoptosis and reduce BC local and metastatic growth in preclinical models." | 7.83 | Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells. ( Albini, A; Bertolini, F; Calleri, A; Dallaglio, K; Gregato, G; Labanca, V; Mancuso, P; Noonan, DM; Orecchioni, S; Reggiani, F; Rossi, T; Talarico, G, 2016) |
| "End-pouch ECA aneurysms were created in adult rats and were then embedded with either platinum or HydroCoils." | 7.83 | Aspirin and Clopidogrel Inhibit Aneurysm Healing after HydroCoil Implantation in External Carotid Artery Aneurysm Model. ( Chaudhary, N; Gemmete, JJ; Li, P; Pandey, AS; Thompson, BG; Xi, G; Zhang, C, 2016) |
| " The effects of AEE on platelet aggregation and anticoagulant in vitro showed that AEE could inhibit adenosine diphosphate (ADP)-induced platelet aggregation as dose-dependence but no notable effect on blood clotting." | 7.81 | Preventive Effect of Aspirin Eugenol Ester on Thrombosis in κ-Carrageenan-Induced Rat Tail Thrombosis Model. ( Li, JY; Liu, GR; Liu, XW; Ma, N; Mohamed, I; Yang, YJ; Zhang, JY, 2015) |
| "MTT assay, colony formation assay, and apoptosis assay were employed to analyze the effects of aspirin on the osteosarcoma cell viability in vitro." | 7.81 | Aspirin Suppresses the Growth and Metastasis of Osteosarcoma through the NF-κB Pathway. ( Duan, T; Hu, K; Kang, T; Liao, D; Lv, X; Wang, G; Wang, X; Zhang, RH; Zhong, L, 2015) |
| "Aspirin has been proposed in recent years as a candidate for chemoprevention of adenocarcinoma in patients with Barrett's esophagus." | 7.80 | Effect of aspirin treatment on the prevention of esophageal adenocarcinoma in a rat experimental model. ( Cebrián, C; Esquivias, P; García-González, MA; Lanas, A; Morandeira, A; Ortego, J; Piazuelo, E; Santander, S, 2014) |
| "Aspirin (ASA) has been frequently used for thromboprophylaxis in patients with multiple myeloma (MM) when treated with thalidomide or lenalidomide." | 7.80 | Aspirin inhibits proliferation and induces apoptosis of multiple myeloma cells through regulation of Bcl-2 and Bax and suppression of VEGF. ( Chen, GA; Ding, JH; Huang, RB; Yuan, LY, 2014) |
| "To examine the effect of meloxicam, a selective COX-2 inhibitor, or low dose aspirin on the development of experimental atherosclerosis in apoE knockout (KO) compared to wild-type (WT) mice." | 7.80 | Aspirin but not meloxicam attenuates early atherosclerosis in apolipoprotein E knockout mice. ( Afek, A; Arber, N; Aroch, I; Eisenberg, O; Finkelstein, A; George, J; Kazanov, D; Kraus, S; Naumov, I; Shapira, S, 2014) |
| " Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats." | 7.79 | Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. ( Agrawal, M; Madhur, G; Mishra, V; Narender, T; Onasanwo, SA; Palit, G; Pandey, HP; Rastogi, P, 2013) |
| "To investigate the effects of long term pretreatment with low-, medium- and high-dose aspirin (acetylsalicylic acid, ASA) on a model of acute pancreatitis (AP) induced in rats." | 7.79 | Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats. ( Akyazi, I; Bala, DA; Cırakli, ZL; Ekiz, EE; Eraslan, E; Gülçubuk, A; Haktanir, D; Matur, E; Ozcan, M; Ozkurt, M, 2013) |
| "We previously demonstrated the pro-metastasis effect of sorafenib in hepatocellular carcinoma (HCC), which is mediated by down-regulation of tumor suppressor HTATIP2." | 7.79 | Aspirin minimized the pro-metastasis effect of sorafenib and improved survival by up-regulating HTATIP2 in hepatocellular carcinoma. ( Ao, JY; Chai, ZT; Kong, LQ; Li, JQ; Lu, L; Sun, HC; Tang, ZY; Wang, L; Wang, WQ; Wu, WZ; Zhang, KZ; Zhang, QB; Zhang, W; Zhang, YY; Zhu, XD, 2013) |
| "Tumor-associated inflammation is a driving force in several adult cancers and intake of low-dose aspirin has proven to reduce cancer incidence." | 7.79 | Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma. ( Carlson, LM; Idborg, H; Jakobsson, PJ; Kogner, P; Rasmuson, A; Segerström, L; Sveinbjörnsson, B, 2013) |
| "To establish a model of acute lung injury induced by paraquat poisoning and to observe the effects of anticoagulant therapy on acute lung injury induced by paraquat poisoning." | 7.78 | [Experimental anticoagulant therapy of acute lung injury induced by paraquat]. ( Bi, YQ; Jian, XD; Jiang, J; Liu, F; Liu, HM; Niu, YY; Shang, B; Tian, D; Zhang, W; Zhang, ZC; Zhou, Q, 2012) |
| "Our findings show that the use of dipyridamole before testicular reperfusion has a potentially protective effect against long-term injury in testicular ischemia reperfusion injury." | 7.78 | Comparison of the protective effect of dipyridamole and acetylsalicylic acid on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury. ( Karagüzel, E; Kazaz, İO; Kutlu, Ö; Mungan, S; Özgür, GK; Tok, DS; Yuluğ, E, 2012) |
| "Hydrogen sulfide (H(2)S) is a novel gaseous mediator that plays important roles in atherosclerosis." | 7.78 | Effect of S-aspirin, a novel hydrogen-sulfide-releasing aspirin (ACS14), on atherosclerosis in apoE-deficient mice. ( Fan, Y; Gu, T; Guo, C; Sparatore, A; Wang, C; Wu, D; Zhang, A; Zhang, H, 2012) |
| "3 nmol) of lipoxin A4 (LXA4), lipoxin B4 (LXB4) or aspirin-triggered-15-epi-lipoxin A4 (ATL) could alleviate the mechanical allodynia in CIBP on day 7 after surgery." | 7.78 | Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines. ( Hu, S; Huang, YL; Jiang, JW; Mao-Ying, QL; Mi, WL; Wang, J; Wang, XW; Wang, YQ; Wang, ZF; Wu, GC, 2012) |
| "Aspirin is associated with a reduced risk of colorectal cancer (CRC), and it showed inhibited effects on interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway which is thought to play an important role in intestinal inflammation and the tumorigenesis of CRC." | 7.77 | Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway. ( Chen, H; Gao, W; Mao, X; Ren, C; Song, T; Tian, Y; Wang, D; Ye, Y, 2011) |
| "To explore the therapeutic effects of aspirin on postmenopausal osteoporosis and understand its action mechanism." | 7.77 | [Effect of aspirin administration for the treatment of osteoporosis in ovariectomized rat model]. ( Chen, ZW; Feng, J; Li, XJ; Qin, GL; Sang, HX; Wang, J; Wang, JC; Wang, LS; Wu, ZX; Zhang, D, 2011) |
| "These findings suggest that ASA changes Th17-type into Th2-type inflammation mainly via the adenosine and uric acid metabolic pathway in the lung." | 7.76 | Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. ( Gyu Jeon, S; Kim, YK; Kim, YS; Moon, HG; Oh, SY; Song Gho, Y; Tae, YM; Zhu, Z, 2010) |
| "Combined antiplatelet agents (cAPA), aspirin plus clopidogrel, increase the risk of bleeding." | 7.76 | Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel. ( Bachelot-Loza, C; Dizier, B; Emmerich, J; Gaussem, P; Godier, A; Grelac, F; Hindy-François, C; Le Bonniec, B; Samama, CM, 2010) |
| " The aim of the present study was to examine the effect of chronic administration of aspirin on metabolic and cardiovascular parameters in fructose-fed rats (FFR), an experimental model of metabolic syndrome." | 7.75 | Effect of chronic aspirin administration on an experimental model of metabolic syndrome. ( González, ES; Lama, MC; Miatello, RM; Renna, NF; Vazquez, MA, 2009) |
| "Aspirin (acetylsalicylic acid) or ibuprofen [2-(4-isobutyl-phenyl)-propionic acid] was administered to mice undergoing treatment of tuberculosis infection with pyrazinamide to determine if these non-steroidal anti-inflammatory drugs (NSAIDs) enhance pyrazinamide activity in vivo." | 7.74 | Aspirin and ibuprofen enhance pyrazinamide treatment of murine tuberculosis. ( Byrne, ST; Denkin, SM; Zhang, Y, 2007) |
| "The results suggest that triflusal and aspirin appear to be equally neuroprotective against middle cerebral artery occlusion-induced cerebral ischemia." | 7.74 | Effects of triflusal and aspirin in a rat model of cerebral ischemia. ( Allen, GV; Bayona, NA; Cechetto, DF; Cheng, G; Hachinski, VC; Whitehead, SN, 2007) |
| "Continuous aspirin treatment (120 mg/kg/d) reduces the expression of proinflammatory cytokines after myocardial infarction, but does not affect post-infarct cardiac remodeling and cardiac function." | 7.74 | High dose aspirin and left ventricular remodeling after myocardial infarction: aspirin and myocardial infarction. ( Adamek, A; Bauersachs, J; Bayer, B; Ertl, G; Frantz, S; Hu, K; Wagner, H, 2007) |
| "The present study was carried out to investigate the effect of the combination of an endothelin antagonist TAK-044 and an antiinflammatory agent aspirin in middle cerebral artery (MCA) occlusion model of acute ischemic stroke in rats." | 7.74 | Effect of combination of endothelin receptor antagonist (TAK-044) and aspirin in middle cerebral artery occlusion model of acute ischemic stroke in rats. ( Briyal, S; Gulati, A; Gupta, YK, 2007) |
| "Acetylsalicylic acid (ASA) and the thienopyridine clopidogrel are established anti-platelet drugs that significantly reduce secondary cardiovascular events in patients with manifest atherosclerosis." | 7.74 | Effect of chronic treatment with acetylsalicylic acid and clopidogrel on atheroprogression and atherothrombosis in ApoE-deficient mice in vivo. ( Koellnberger, M; Konrad, I; Lorenz, R; Massberg, S; Orschiedt, L; Sauer, S; Schulz, C; Walter, U, 2008) |
| "COX-1-dependent eicosanoid formation accelerates atherogenesis, and low-dose aspirin reduces early atherosclerosis." | 7.73 | Stabilization of advanced atherosclerosis in low-density lipoprotein receptor-deficient mice by aspirin. ( Cyrus, T; Praticò, D; Tung, LX; Yao, Y, 2006) |
| "To investigate the possible effects of nuclear factor-KappaB (NF-KappaB) activation on the expression of intercellular adhesion molecular-1 (ICAM-1) and P-selectin in murine acute lung injury (ALI) and assess the potential beneficial effects and mechanism of low molecular weight heparin (LMWH) and aspirin (ASA)." | 7.73 | [Therapeutic effects of low molecular weight heparin and aspirin on acute lung injury in rat]. ( Luan, ZG; Ma, XC; Nala, P; Zhang, ZD, 2006) |
| " Cardiac lesions induced by isoproterenol (ISO) are characterized by myocardial necrosis and exudative infiltration." | 7.72 | Effect of D-003 on isoproterenol-induced myocardial necrosis in rats. ( Arruzazabala, ML; Carbajal, D; González, J; Más, R; Mendoza, S; Molina, V; Noa, M, 2003) |
| "Using automatic erythrocyte aggregometer type MA-1 (Myrenne gmbh, Germany), we investigated the hypothesis that therapeutic effectiveness of quinapril--angiotensin converting enzyme inhibitor (ACEI)--in the treatment of hypertension would correlate with improvement of red blood cell (RBC) aggregability." | 7.72 | Secretory dysfunction of vascular endothelium limits the effect of angiotensin converting enzyme inhibitor quinapril on aggregation of erythrocytes in experimental hypertension. ( Adamek-Guzik, T; Korbut, R; Korbut, RA; Madej, J, 2003) |
| "To investigate the protective effects and mechanism of action of aspirin on focal cerebral ischemia-reperfusion rats." | 7.72 | [Protective effects and mechanism of action of aspirin on focal cerebral ischemia-reperfusion in rats]. ( Chen, CH; Qiu, LY; Yu, J; Zhou, Y, 2003) |
| "Chronic in vivo treatment with aspirin prevented the development of hypertension and reduced insulin resistance significantly in chronically glucose-fed rats." | 7.71 | Prevention of hypertension, hyperglycemia and vascular oxidative stress by aspirin treatment in chronically glucose-fed rats. ( de Champlain, J; El Midaoui, A; Wu, R, 2002) |
| "The present study was designed to evaluate the effects of a potassium channel opener, nicorandil, and to elucidate its possible mechanism of action in aspirin plus pylorus ligation induced and ethanol-induced gastric ulcers in rats." | 7.71 | Evaluation of the effects of nicorandil on experimentally induced gastric ulcers. ( Goswami, SG; Patel, HM; Santani, DD, 2001) |
| " We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat." | 7.71 | Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001) |
| "In this study the severity of aspirin-induced gastric mucosal damage was investigated in rats with obstructive cholestasis." | 7.70 | Enhancement of aspirin-induced gastric damage by cholestasis in rats. ( Alikhani, Z; Dehpour, AR; Ghaffari, K; Mani, AR; Nowroozi, A; Sabbagh, B; Sadr, S; Sharif, A; Toor Savadkoohi, S; Zeinoddini, M, 1998) |
| "Isoproterenol hydrochloride (ISO), a beta adrenergic agonist, is known to cause ischemic necrosis in rats." | 7.70 | Effect of a novel tetrapeptide derivative in a model of isoproterenol induced myocardial necrosis. ( Jayakumar, R; Jayasundar, S; Malarvannan, P; Puvanakrishnan, R; Ramesh, CV, 1998) |
| "Diaspirin cross-linked hemoglobin (DCLHb) is a vasoactive hemoglobin-based oxygen carrier or "blood substitute" that has been shown to improve base deficit in several experimental studies of hemorrhagic shock." | 7.70 | The effects of diaspirin cross-linked hemoglobin on hemodynamics, metabolic acidosis, and survival in burned rats. ( Hansbrough, JF; Soltero, RG, 1999) |
| "To evaluate the effect of singular or sustained hemodilution, with alpha-alpha diaspirin crosslinked hemoglobin (DCLHb), on the area of hypoperfusion after subarachnoid hemorrhage." | 7.70 | Subarachnoid hemorrhage in rats: effect of singular or sustained hemodilution with alpha-alpha diaspirin crosslinked hemoglobin on cerebral hypoperfusion. ( Cole, DJ; Drummond, JC; Jacobsen, WK; Nary, JC; Patel, PM; Reynolds, LW, 1999) |
| "This study examined the effect of low dose aspirin on cardiorenal and neurohumoral function and on the acute hemodynamic response to enalaprilat in a canine model of heart failure." | 7.69 | Effect of low dose aspirin on cardiorenal function and acute hemodynamic response to enalaprilat in a canine model of severe heart failure. ( Burnett, JC; Evans, MA; Redfield, MM, 1995) |
| "Adding NTG to a thrombolytic regimen with rt-PA, aspirin and heparin increases the magnitude of restored flow and total patency duration following recanalization in a rabbit model of arterial thrombosis." | 7.69 | Beneficial effect of nitroglycerin on arterial rethrombosis after thrombolysis. Results from a rabbit thrombosis model. ( Battler, A; Chernine, A; Hasdai, D; Kornowski, R; Ovadia, Z, 1995) |
| "Aspirin, when compared to placebo and controls, significantly increased muscle interstitial oedema when given orally and intravenously." | 7.69 | Aspirin increases tissue oedema after skeletal muscle ischaemia and reperfusion. ( Braithwaite, BD; Earnshaw, JJ; Gelabert, H; Moore, WS; Petrik, PV; Pollen, DN; Quinones-Baldrich, WJ, 1996) |
| "Inogatran (MW 439 Da), a new, selective, active site inhibitor of thrombin, was evaluated in three rat models of thrombosis." | 7.69 | Effects of inogatran, a new low-molecular-weight thrombin inhibitor, in rat models of venous and arterial thrombosis, thrombolysis and bleeding time. ( Börjesson, I; Elg, M; Gustafsson, D; Lenfors, S; Teger-Nilsson, AC, 1996) |
| "We determined the effects of aspirin and a novel thromboxane A2/prostaglandin endoperoxide (TP)-receptor antagonist, BMS-180291, on thrombosis and bleeding times in skin and mesenteric arteries." | 7.68 | Superior activity of a thromboxane receptor antagonist as compared with aspirin in rat models of arterial and venous thrombosis. ( Heran, CL; Ogletree, ML; Schumacher, WA; Steinbacher, TE; Youssef, S, 1993) |
| "The antithrombotic effects of the thromboxane (TX) A2-receptor antagonist and aspirin were determined using a photochemically-induced arterial thrombosis model in the femoral arteries of guinea pigs." | 7.68 | Inhibitory effect of KW-3635, a new thromboxane A2-receptor antagonist, on arterial thrombosis in guinea pigs. ( Higo, K; Karasawa, A, 1993) |
| "The effects of hemorrhagic shock, aspirin, and ethanol on the biochemical and morphologic changes of experimental pancreatitis were evaluated." | 7.68 | Effects of hemorrhagic shock, aspirin, and ethanol on secretagogue-induced experimental pancreatitis. ( Leli, U; Printz, H; Saluja, A; Sengupta, A; Steer, M, 1990) |
| "The ouabain threshold to induce cardiac arrhythmias in urethane-anaesthetized guinea-pigs was not modified by the administration of either dazmegrel, 4 mg/kg i." | 7.68 | Protective effects of dazmegrel on the PAF potential of ouabain-induced cardiac arrhythmias. ( Barrigón, S; Salinas, P, 1991) |
| "The intravenous administration of either aspirin, (in doses of 1 and 3 mg/kg) sodium meclofenamate (1 and 3 mg/kg) or indomethacin (1 and 3 mg/kg) markedly reduced ventricular arrhythmias (VT and VF) induced by coronary artery ligation in anaesthetised rats." | 7.67 | The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats. ( Fagbemi, SO, 1984) |
| "Cardiovascular responses to the calcium antagonist nifedipine, alone and combined with low dose acetylsalicyclic acid (ASA), were evaluated in a piglet model of endotoxin-induced pulmonary hypertension." | 7.67 | The effect of nifedipine alone or combined with low dose acetylsalicyclic acid on endotoxin-induced pulmonary hypertension in the piglet. ( Huth, RG; Jüngst, BK; Schranz, D; Stopfkuchen, H, 1988) |
| "The effects of ticlopidine and aspirin on endotoxin-induced experimental disseminated intravascular coagulation (DIC) were studied in rats." | 7.66 | Effects of ticlopidine and aspirin on endotoxin-induced disseminated intravascular coagulation in rats. ( Furukawa, Y; Kondo, M; Murakami, M; Takemura, S; Yoshikawa, T, 1983) |
| " 9 The results are also discussed in relation to the genesis of aspirin-induced asthma in man." | 7.66 | Spontaneous activity in the trachea of dogs treated with indomethacin: an experimental model for aspirin-related asthma. ( Ito, Y; Tajima, K, 1981) |
| "The effects of cimetidine, a new histamine H2-receptor antagonist, on the development of experimental gastric and duodenal ulcers were studied." | 7.65 | Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. ( Okabe, S; Takagi, K; Takeuchi, K; Urushidani, T, 1977) |
| "Tendinopathy is a common musculoskeletal system disorder in sports medicine, but regeneration ability of injury tendon is limited." | 5.56 | Aspirin promotes tenogenic differentiation of tendon stem cells and facilitates tendinopathy healing through regulating the GDF7/Smad1/5 signaling pathway. ( Bian, X; Chen, W; He, G; Kang, X; Lyu, J; Mu, M; Shi, Y; Tang, H; Tang, K; Wang, Y; Yang, M; Yuan, C; Zhang, J; Zhou, B; Zhou, M; Zhu, M, 2020) |
| " Therefore, the goal of this paper was to create a physiologically based pharmacokinetic (PBPK) model to offer a reasonable starting point for required total AT-RvD1 dosage to be administered in future mice and humans thereby eliminating the need for excessive use of animals and humans in preclinical and clinical trials, respectively." | 5.56 | Predictive modeling of aspirin-triggered resolvin D1 pharmacokinetics for the study of Sjögren's syndrome. ( Baker, OJ; Yellepeddi, VK, 2020) |
| "The presence or absence of thrombus in the vein graft samples was recorded under light microscopy." | 5.56 | Drug-eluting Vein Graft with Acetylsalicylic Acid-Ticagrelor-Unfractionated Heparin Complex Inhibits Early Graft Thrombosis ( Akşit, E; Büyük, B; Çokkalender, Ö; Kurt, T, 2020) |
| "Melanoma is the most aggressive and fatal type of skin cancer due to being highly proliferative." | 5.56 | Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis. ( Abou-Kheir, W; Ausina, P; Branco, JR; Demaria, TM; Esteves, AM; Leandro, JGB; Mendonça, APM; Ochioni, AC; Oliveira, MF; Palhano, FL; Sola-Penna, M; Zancan, P, 2020) |
| "Aspirin plays an important role in the prevention and therapy of pre-eclampsia." | 5.51 | Ameliorative effects of pre-eclampsia by quercetin supplement to aspirin in a rat model induced by L-NAME. ( Ma, Y; Shi, X; Song, L; Yang, S; Zhao, N, 2019) |
| "Aspirin treatment suppressed toll‑like receptor (TLR)4 and nuclear factor (NF)‑κB expression in cerebrovascular endothelial cells." | 5.48 | Aspirin ameliorates cerebral infarction through regulation of TLR4/NF‑κB‑mediated endoplasmic reticulum stress in mouse model. ( Cui, X; Shen, B; Sun, D; Wang, X, 2018) |
| "Mild hyperhomocysteinemia is considered a risk factor for development of neurodegenerative diseases." | 5.48 | Chronic Mild Hyperhomocysteinemia Alters Inflammatory and Oxidative/Nitrative Status and Causes Protein/DNA Damage, as well as Ultrastructural Changes in Cerebral Cortex: Is Acetylsalicylic Acid Neuroprotective? ( de S Moreira, D; Figueiró, PW; Guma, FCR; Manfredini, V; Prezzi, CA; Rohden, F; Siebert, C; Wyse, ATS, 2018) |
| "Preeclampsia is a severe pregnancy-related disorder, and patients usually present with high circulating inflammatory factor levels and excessive activation of the nuclear factor-κB (NF-κB) pathway." | 5.48 | The intervention effect of aspirin on a lipopolysaccharide-induced preeclampsia-like mouse model by inhibiting the nuclear factor-κB pathway. ( Li, G; Lin, L; Ma, L; Wang, YL; Yang, H, 2018) |
| "Non-alcoholic fatty liver disease (NAFLD) is now a public health issue worldwide, but no drug has yet received approval." | 5.48 | Genistein Ameliorates Non-alcoholic Fatty Liver Disease by Targeting the Thromboxane A ( Chen, J; Chen, W; Li, H; Mao, J; Wang, M; Wang, W; Zhang, H, 2018) |
| "Aspirin treatment significantly decreased the levels of pro-inflammatory cytokines in serum and placenta tissues of preeclampsia rats." | 5.48 | Ameliorative effects of aspirin against lipopolysaccharide-induced preeclampsia-like symptoms in rats by inhibiting the pro-inflammatory pathway. ( Liu, F; Lu, X; Sun, J; Tang, D; Zhang, H, 2018) |
| "Thus treatment with aspirin in the chronic phase of Chagas' disease changes the natural history of the disease and raises the possibility of using it as a new therapeutic approach to the treatment of this aspect of Chagas' disease pathology." | 5.46 | Treatment with low doses of aspirin during chronic phase of experimental Chagas' disease increases oesophageal nitrergic neuronal subpopulation in mice. ( de Almeida Araújo, EJ; de Mello Gonçales Sant'ana, D; Marques de Araújo, S; Martins Moreira, N; Massocatto, CL; Muniz, E; Pinge-Filho, P; Rossi, RM, 2017) |
| "Amitriptyline was also used in combination with aspirin and dexamethasone to inspect any synergistic effects." | 5.43 | Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats. ( Bhatt, S; Goswami, S; Raval, J; Shukla, P, 2016) |
| "Aspirin is a very common anti-inflammatory medication to relieve aches and pains." | 5.43 | Aspirin-Based Carbon Dots, a Good Biocompatibility of Material Applied for Bioimaging and Anti-Inflammation. ( Bu, W; Chang, B; Gu, Z; Li, C; Lin, C; Shen, Y; Sun, H; Xu, X; Yang, B; Zhang, K; Zhao, L; Zheng, C, 2016) |
| "There are many available drugs for treating gastric ulcer, but they have various side effects." | 5.42 | The postulated mechanism of the protective effect of ginger on the aspirin induced gastric ulcer: Histological and immunohistochemical studies. ( Salah Khalil, M, 2015) |
| "Kaempferol was shown to attenuate the expansion of inflammatory lesions seen in ethanol (EtOH)/HCl- and aspirin-induced gastritis, LPS/caerulein (CA) triggered pancreatitis, and acetic acid-induced writhing." | 5.42 | Kaempferol, a dietary flavonoid, ameliorates acute inflammatory and nociceptive symptoms in gastritis, pancreatitis, and abdominal pain. ( Baek, KS; Cho, JY; Ha, VT; Kim, E; Kim, HG; Kim, JH; Kim, SH; Lee, MN; Park, JG; Sung, GH; Sung, NY; Yang, S; Yang, WS; Yi, YS, 2015) |
| "Simvastatin has important immune-modulatory and anti-inflammatory effects independent of lipid lowering effects." | 5.40 | Effect of simvastatin on inflammatory cytokines balance in air pouch granuloma model. ( Al-Gayyar, MM; El-Gayar, AM; Hassan, HM; Ibrahim, TM, 2014) |
| "Stroke is the major cause of death and decrease in the activities of daily living." | 5.40 | Neurovascular protection of cilostazol in stroke-prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation. ( Abe, K; Deguchi, K; Ikeda, Y; Kono, S; Kurata, T; Liu, N; Liu, W; Omote, Y; Yamashita, T, 2014) |
| "Stroke is the second leading cause of death." | 5.39 | Neuroprotective effect of a new synthetic aspirin-decursinol adduct in experimental animal models of ischemic stroke. ( Ahn, JH; Cho, JH; Choi, JH; Her, S; Hwang, IK; Hyun, BH; Jun, JG; Kim, CK; Kim, IH; Kim, JS; Kim, YM; Kwon, SH; Kwon, YG; Lee, CH; Lee, JC; Lee, YL; Park, JH; Shin, BN; Suh, HW; Won, MH; Yan, BC; Yoo, KY, 2013) |
| "Aspirin is an anti-inflammatory drug demonstrated to possess a tremendous anticancer potential." | 5.38 | Gender-specific antitumor action of aspirin in a murine model of a T-cell lymphoma bearing host. ( Bharti, AC; Kumar, A; Singh, SM; Vishvakarma, NK, 2012) |
| "Focal cerebral ischemia was induced by MCA occlusion for 2 hours followed by reperfusion for 22 hours." | 5.37 | Protective effect of irbesartan, an angiotensin II receptor antagonist, alone and in combination with aspirin on middle cerebral artery occlusion model of focal cerebral ischemia in rats. ( Ahmad, SJ; Akhtar, M; Islam, F; Khanam, R; Pillai, KK; Pratap, R, 2011) |
| "Choline is a α7 nicotinic receptor agonist that has antinociceptive effects in a variety of pain models." | 5.37 | Pharmacological action of choline and aspirin coadministration on acute inflammatory pain. ( Hai, W; Hai-Tao, Y; Jin-Da, W; Ru-Huan, W; Xiang-Di, Z; Yong-Ping, S, 2011) |
| "Naproxen, which has an excellent cardiovascular profile, or epidermal growth factor receptor inhibitors may be effective in an adjuvant setting." | 5.36 | Screening agents for preventive efficacy in a bladder cancer model: study design, end points, and gefitinib and naproxen efficacy. ( Grubbs, CJ; Juliana, MM; Lubet, RA; Steele, VE, 2010) |
| " The authors--in view of the increased neuroinflammatory reaction frequently observed during normal brain ageing--suggest the long-term use of "fatty aspirin", an association of DHA and/or NPD1 and aspirin (or nitroaspirin), to postpone, or prevent, the structural neurodegeneration of the brain." | 5.35 | Fatty aspirin: a new perspective in the prevention of dementia of Alzheimer's type? ( Bria, P; Di Gioia, A; Pomponi, M; Pomponi, MF, 2008) |
| "Curcumin is a yellow-colored plant polyphenol with a long history of medicinal use in ayurvedic, Chinese and Japanese medicine." | 5.35 | Curcumin potentiates the anti-inflammatory activity of cyclooxygenase inhibitors in the cotton pellet granuloma pouch model. ( Chopra, K; Dhir, A; Kuhad, A; Nandal, S; Sharma, S, 2009) |
| "Atherosclerosis is an inflammatory response of the arterial wall to 'injury', which is prominently driven by inflammatory factors." | 5.34 | Effect of clopidogrel on the inflammatory progression of early atherosclerosis in rabbits model. ( Li, M; Ren, H; Zhang, Y; Zhu, X, 2007) |
| " Low-dose razaxaban was useful in combination with sub-optimal doses of aspirin and/or clopidogrel for the prevention of occlusive arterial thrombosis without excessive bleeding." | 5.34 | Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits. ( Crain, EJ; Knabb, RM; Lam, PY; Quan, ML; Watson, CA; Wexler, RR; Wong, PC, 2007) |
| "When choline (2 mg/kg) was coadministered with aspirin (9." | 5.33 | Antinociceptive effects of choline against acute and inflammatory pain. ( Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y, 2005) |
| "ASA, captopril or losartan were given at a concentration of 40 mg/kg/day in drinking water." | 5.32 | Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. ( Browne, AE; Chatterjee, K; Grossman, W; Karliner, JS; Lee, RJ; Parmley, WW; Sievers, RE; Zhu, BQ, 2003) |
| "Bradykinin is a potent endothelium-dependent vasodilator in the coronary vascular bed." | 5.32 | Involvement of nitric oxide and prostaglandin pathways in the cardioprotective actions of bradykinin in rats with experimental myocardial infarction. ( Akula, A; Veeravalli, KK, 2004) |
| "However, systemic study of thrombus formation in vein grafts is still lacking, and few effective techniques are available to prevent this event." | 5.32 | Thrombosis and neointima formation in vein grafts are inhibited by locally applied aspirin through endothelial protection. ( Hu, Y; Mayr, U; Thompson, WD; Torsney, E; Xu, Q; Zou, Y, 2004) |
| "Main parameter was thrombus weight." | 5.32 | Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model. ( Bégaud, B; Boisseau, M; Moore, N; Umar, A; Upur, H; Yusup, A, 2004) |
| "Endothelial dysfunction, defined as a deficit in the bioavailability of nitric oxide (NO), occurs as sequelae of many vascular diseases; however, the utility of supplementing NO to obviate the extent of disease is understudied." | 5.31 | Nitric oxide-releasing aspirin decreases vascular injury by reducing inflammation and promoting apoptosis. ( Rudic, RD; Sessa, WC; Yu, J, 2002) |
| " Combination therapy may produce synergic effects with better tumor inhibition as well as lower dosage or side affects." | 5.31 | [Effects of combination of octreotide and aspirin on proliferation of human hepatocellular carcinoma]. ( Tang, CW; Tang, LP; Wang, CH, 2002) |
| " A statistically significant increase in the threshold for 2 kHz was found 1 to 72 hr after dosing but not for 4, 8 and 10 kHz." | 5.30 | Frequency selectivity on aspirin-induced hearing loss in rats with auditory stimulus-induced conditioned suppression. ( Kurata, K; Nishida, N; Sato, S; Suzuki, T; Tokuriki, M; Tsukuda, R, 1997) |
| "This produced an occlusive thrombus in all vehicle-treated ferrets within 41 +/- 3 min with an average weight of 8 +/- 1 mg (n = 7)." | 5.29 | A ferret model of electrical-induction of arterial thrombosis that is sensitive to aspirin. ( Durham, SK; Megill, JR; Schumacher, WA; Steinbacher, TE, 1996) |
| "Thrombus was formed within seconds after laser injury and grew rapidly." | 5.29 | Antithrombotic effects of aspirin and LMWH in a laser-induced model of arterials and venous thrombosis. ( Aguejouf, O; Doutremepuich, C; Doutremepuich, F; Imbault, P, 1996) |
| "injection inhibited thrombus formation in small mesenteric vessels for more than 12 hours but less than 24 hours." | 5.28 | [Evaluation of the antithrombotic effects of pentoxifylline, acetylsalicylic acid and low molecular weight heparin in the laser model of thrombosis]. ( Bielawiec, M; Breddin, HK; Krupiński, K; Płonowski, A, 1992) |
| "Picotamide did not inhibit the formation of TxB2 in serum at any of the doses tested (100 to 750 mg/kg i." | 5.28 | Picotamide protects mice from death in a pulmonary embolism model by a mechanism independent from thromboxane suppression. ( Alberti, P; Corona, C; Gresele, P; Nenci, GG, 1990) |
| " These occurred only in the groups given MNNG in combination with stress, aspirin, or sodium taurocholate, and did not occur in experimental groups given either MNNG, stress, aspirin, or sodium taurocholate alone, and did not occur in the control group." | 5.27 | Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate. ( Cohen, A; Geller, SA; Horowitz, I; Toth, LS; Werther, JL, 1984) |
| " Moreover, the results of clinical studies have shown that the antiplatelet drug aspirin reduces the incidence of vascular events and colorectal cancer." | 4.90 | Role of platelets in inflammation and cancer: novel therapeutic strategies. ( Alberti, S; Dovizio, M; Guillem-Llobat, P; Patrignani, P, 2014) |
| "Lipoxins and aspirin-triggered lipoxins are lipid mediators generated from arachidonic acid that act to reduce inflammation and promote resolution." | 4.83 | Lipoxins and new lipid mediators in the resolution of inflammation. ( Schwab, JM; Serhan, CN, 2006) |
| "The current standard of care for the treatment of arterial thrombosis includes anticoagulants and three classes of antiplatelet agents--aspirin, thienopyridines and glycoprotein IIb-IIIa antagonists." | 4.82 | Therapeutic approaches in arterial thrombosis. ( Andre, P; Conley, PB; Phillips, DR; Sinha, U, 2005) |
| " In elective de novo lesions has shown remarkably clear lumens at follow-up angiography and intravascular ultrasound within the stented segments were observed with no lesion progression at the stent margins or thrombosis after a 2 month regimen of aspirin, and ticlopodine or clopidogrel." | 4.81 | Sirolimus-eluting stents: a review of experimental and clinical findings. ( Albiero, R; Colombo, A; Corvaja, N; Di Mario, C; Falotico, R; Stankovic, G; Takagi, T; Toutouzas, K, 2002) |
| "Our results demonstrated that the combination of quercetin and aspirin exerted significantly stronger effects than aspirin alone on decreasing systolic blood pressure and proteinuria, reducing pro-inflammatory cytokine production, and inhibiting M1-type decidual macrophages polarization in an LPS-induced rat model of preeclampsia." | 4.31 | Natural Flavonoid Quercetin Enhances the Anti-inflammatory Effects of Aspirin in a Preeclampsia-like Rat Model Induced by Lipopolysaccharide. ( Chen, D; Ding, J; Liu, A; Yang, S, 2023) |
| "Aspirin induced TTS can protect from cisplatin-induced ototoxicity." | 4.31 | The protective effect of aspirin-induced temporary threshold shift in an animal model of cisplatin-related ototoxicity. ( Attias, J; Barkan, N; Hikri, E; Hilly, O; Mizrachi, A; Shivatzki, S; Tzelnick, S; Yosefof, E, 2023) |
| " Paracetamol and aspirin were used to induce hepatotoxicity and gastric ulcer in rats, respectively." | 4.12 | Evaluation of Hepatoprotective and Gastroprotective Activities of Paspalidium flavidum Leaves Extract in Experimental Animal Models. ( Ahsan, H; Anjum, I; Ismail, S; Kahrizi, D; Movafagh, A; Naveed Mushtaq, M; Ramzan, HM; Razzaq, A; Shabbir, U; Shoukat, A, 2022) |
| " Therapeutic strategies using lipid mediators, such as aspirin-triggered resolvin D1 (ATRvD1), can contribute to the resolution of acute and chronic inflammation." | 4.02 | ATRvD1 Attenuates Renal Tubulointerstitial Injury Induced by Albumin Overload in Sepsis-Surviving Mice. ( Almeida-Souza, F; Benjamim, CF; Calabrese, KS; Calcia, TBB; Caruso-Neves, C; Guilherme, RF; Lemos, FS; Neves, JS; Silva, CP; Silva, JBNF, 2021) |
| "Aspirin reduces the incidence of conventional adenomas driven by APC mutation and thus colorectal cancer." | 4.02 | Aspirin reduces the incidence of metastasis in a pre-clinical study of Braf mutant serrated colorectal neoplasia. ( Bond, CE; Fennell, LJ; Kane, AM; Leggett, BA; Liu, C; McKeone, DM; Pollock, PM; Whitehall, VLJ; Young, G, 2021) |
| " To evaluate the analgesic effects of AC, 4 different pain models including hot plate assay, acetic acid writhing assay, formalin and CFA induced pain models were adopted in this study." | 4.02 | Comparison of analgesic activities of aconitine in different mice pain models. ( Chen, J; Deng, J; Feng, Q; Han, J; Huang, Q; Leung, EL; Liu, Z; Lu, L; Qi, X; Wang, D; Wang, Y; Zhang, Y, 2021) |
| "The protective effect of aspirin against myocardial hypertrophy (MH) was studied." | 4.02 | The Protective Effect of Aspirin against Myocardial Hypertrophy in Rats. ( Fan, X; Liu, J; Ma, X; Wei, M; Wu, X; Xue, M; Zhang, H, 2021) |
| "Beside its therapeutic role in the thrombotic vascular events, Clopidogrel confers significant protection against ischemic myocardial injury by counteracting the platelet-mediated inflammation and oxidative stress associated with HFD-C consumption in animals." | 3.96 | Clopidogrel Prophylaxis Abates Myocardial Ischemic Injury and Inhibits the Hyperlipidemia-Inflammation Loop in Hypercholestrolemic Mice. ( Korish, AA, 2020) |
| "Discrepancies in preclinical studies of aspirin (ASA) antiplatelet activity in mouse models of bleeding and arterial thrombosis led us to evaluate commonly reported methods in order to propose a procedure for reliably measuring the effects of single dose ASA on mouse hemostasis." | 3.91 | Evaluation of commonly used tests to measure the effect of single-dose aspirin on mouse hemostasis. ( Bachelot-Loza, C; Belleville-Rolland, T; Decouture, B; Dizier, B; Gaussem, P; Leuci, A; Mansour, A; Martin, F; Pidard, D, 2019) |
| "It was concluded that simultaneous inhibition of the JAK-STAT and NF-κB signalling pathways with tofacitinib and aspirin respectively, could mitigate insulin resistance and hyperglycemia in T2D." | 3.91 | Inhibition of JAK-STAT and NF-κB signalling systems could be a novel therapeutic target against insulin resistance and type 2 diabetes. ( Bako, HY; Ibrahim, MA; Ibrahim, S; Isah, MS, 2019) |
| "We assessed the effects of ticagrelor, aspirin and prasugrel, started 7days after myocardial ischemia-reperfusion injury on remodeling, inflammation and fibrosis in the rat." | 3.91 | Ticagrelor Improves Remodeling, Reduces Apoptosis, Inflammation and Fibrosis and Increases the Number of Progenitor Stem Cells After Myocardial Infarction in a Rat Model of Ischemia Reperfusion. ( Birnbaum, Y; Chen, H; Nylander, S; Sampaio, LC; Tran, D; Ye, Y, 2019) |
| "Present study was planned to estimate the gastroprotective activity of Euphorbia prostrata plant against aspirin induced gastric ulcers in male adult albino rabbits." | 3.91 | Gastroprotective and antioxidant potential of Euphorbia prostrata against aspirin induced gastric ulcers in rabbits. ( Ahmad, M; Aslam, B; Mohsin, M; Muhammad, F; Raza, A, 2019) |
| " Our aim was to examine local and remote consequences of ASA-Tris administration in 2-,4-,6-trinitrobenzene-sulfonic acid (TNBS)-induced colitis as compared to ASA or mesalamine (5-aminosalicylate) treatment." | 3.88 | Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis. ( Boros, M; Érces, D; Ghyczy, M; Hartmann, P; Jász, DK; Lajkó, N; Molnár, R; Szűcs, S; Tóth, G; Ugocsai, M; Varga, G, 2018) |
| "Our study reveals a novel mechanism by which aspirin alleviates pressure overload-induced cardiac interstitial fibrosis in TAC mice by suppressing the p-Erk1/2 and p-Akt/β-catenin signalling pathways." | 3.88 | Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways. ( E, X; Feng, Y; Gitau, SC; Li, T; Li, X; Liang, H; Liu, X; Qian, M; QiLi, M; Shan, H; Shen, Z; Wang, G; Xu, B; Zhang, Y; Zhao, D, 2018) |
| "Aspirin prevented aneurysm rupture in a mouse intracranial aneurysm model, while cilostazol did not." | 3.88 | Prevention Effect of Antiplatelets on Aneurysm Rupture in a Mouse Intracranial Aneurysm Model. ( Hiramatsu, H; Hokamura, K; Kamio, Y; Kimura, T; Makino, H; Namba, H; Suzuki, T; Umemura, K; Yamasaki, T, 2018) |
| "Antipsychotic drugs plus aspirin (acetylsalicylic acid), which targets prostaglandin-endoperoxide synthase 1 (PTGS1: COX1), improved therapeutic outcomes when treating schizophrenia." | 3.88 | Studies on Prostaglandin-Endoperoxide Synthase 1: Lower Levels in Schizophrenia and After Treatment with Antipsychotic Drugs in Conjunction with Aspirin. ( Dean, B; Gibbons, A; Gogos, A; Scarr, E; Thomas, E; Udawela, M, 2018) |
| "Aspirin was substantially more effective than salicylate in reducing or delaying aggregation in human neuroblastoma cells grown in vitro, and in Caenorhabditis elegans models of human neurodegenerative diseases in vivo." | 3.85 | Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation. ( Alla, R; Ayyadevara, S; Balasubramaniam, M; Kakraba, S; Mehta, JL; Shmookler Reis, RJ, 2017) |
| "The consequences of using aspirin (ASA) for the pathogenesis of Chagas disease are unclear." | 3.85 | Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease. ( Araújo, EJ; Massocatto, CL; Moreira, NM; Muniz, E; Pinge-Filho, P; Rossi, RM; Sant'Ana, DM, 2017) |
| "Metformin can induce breast cancer (BC) cell apoptosis and reduce BC local and metastatic growth in preclinical models." | 3.83 | Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells. ( Albini, A; Bertolini, F; Calleri, A; Dallaglio, K; Gregato, G; Labanca, V; Mancuso, P; Noonan, DM; Orecchioni, S; Reggiani, F; Rossi, T; Talarico, G, 2016) |
| "To characterize the effect of aspirin (ASA) in mouse models of choroidal neovascularization (CNV) and retinal degeneration." | 3.83 | Effect of aspirin on models of retinal pigment epithelium pathology. ( Ali, O; Bora, NS; Bora, PS; Goyal, S; Lyzogubov, VV; Uwaydat, SH, 2016) |
| "To investigate the efficacy of intralesional 20% aspirin injection for treatment of experimental peritoneal endometriosis." | 3.83 | Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits. ( Barretto, AB; Denadai, R; Saad-Hossne, R; Siqueira, JM, 2016) |
| "End-pouch ECA aneurysms were created in adult rats and were then embedded with either platinum or HydroCoils." | 3.83 | Aspirin and Clopidogrel Inhibit Aneurysm Healing after HydroCoil Implantation in External Carotid Artery Aneurysm Model. ( Chaudhary, N; Gemmete, JJ; Li, P; Pandey, AS; Thompson, BG; Xi, G; Zhang, C, 2016) |
| " The aim of this study was to evaluate the protective potential of implanted human umbilical cord mesenchymal stem (hUCMs) cells with/without aspirin (ASA) against focal cerebral ischemia." | 3.81 | Coadministration of the Human Umbilical Cord Matrix-Derived Mesenchymal Cells and Aspirin Alters Postischemic Brain Injury in Rats. ( Eslaminejad, T; Esmaeilpour, K; Nematollahi-Mahani, SN; Shams ara, A; Sheibani, V, 2015) |
| " The effects of AEE on platelet aggregation and anticoagulant in vitro showed that AEE could inhibit adenosine diphosphate (ADP)-induced platelet aggregation as dose-dependence but no notable effect on blood clotting." | 3.81 | Preventive Effect of Aspirin Eugenol Ester on Thrombosis in κ-Carrageenan-Induced Rat Tail Thrombosis Model. ( Li, JY; Liu, GR; Liu, XW; Ma, N; Mohamed, I; Yang, YJ; Zhang, JY, 2015) |
| "MTT assay, colony formation assay, and apoptosis assay were employed to analyze the effects of aspirin on the osteosarcoma cell viability in vitro." | 3.81 | Aspirin Suppresses the Growth and Metastasis of Osteosarcoma through the NF-κB Pathway. ( Duan, T; Hu, K; Kang, T; Liao, D; Lv, X; Wang, G; Wang, X; Zhang, RH; Zhong, L, 2015) |
| " Aspirin 150 mg/kg was used to induce gastric ulcer in all groups except normal control." | 3.81 | Histopathological evaluation of gastro protective effect of Berberis vulgaris (Zereshk) seeds against aspirin induced ulcer in albino mice. ( Ali, A; Aslam, B; Javed, I; Khaliq, T; Majeed, W; Muhammad, F; Raza, A, 2015) |
| "Clopidogrel but not aspirin showed the ability of preventing bone loss in experimental periodontitis." | 3.80 | Antiplatelet drugs reduce the immunoinflammatory response in a rat model of periodontal disease. ( Coimbra, LS; Muscará, MN; Rossa, C; Spolidorio, LC; Steffens, JP, 2014) |
| "Aspirin has been proposed in recent years as a candidate for chemoprevention of adenocarcinoma in patients with Barrett's esophagus." | 3.80 | Effect of aspirin treatment on the prevention of esophageal adenocarcinoma in a rat experimental model. ( Cebrián, C; Esquivias, P; García-González, MA; Lanas, A; Morandeira, A; Ortego, J; Piazuelo, E; Santander, S, 2014) |
| "Aspirin (ASA) has been frequently used for thromboprophylaxis in patients with multiple myeloma (MM) when treated with thalidomide or lenalidomide." | 3.80 | Aspirin inhibits proliferation and induces apoptosis of multiple myeloma cells through regulation of Bcl-2 and Bax and suppression of VEGF. ( Chen, GA; Ding, JH; Huang, RB; Yuan, LY, 2014) |
| "To examine the effect of meloxicam, a selective COX-2 inhibitor, or low dose aspirin on the development of experimental atherosclerosis in apoE knockout (KO) compared to wild-type (WT) mice." | 3.80 | Aspirin but not meloxicam attenuates early atherosclerosis in apolipoprotein E knockout mice. ( Afek, A; Arber, N; Aroch, I; Eisenberg, O; Finkelstein, A; George, J; Kazanov, D; Kraus, S; Naumov, I; Shapira, S, 2014) |
| "Overall, this study suggested that both celecoxib and aspirin could prevent breast cancer growth by regulating proteins in the cell cycle and apoptosis without blocking estrogen synthesis." | 3.80 | Celecoxib increases miR-222 while deterring aromatase-expressing breast tumor growth in mice. ( Chan, FL; Chen, S; Leung, LK; Li, F; Lin, SM; Wong, TY, 2014) |
| "A murine model of asbestos-induced mesothelioma was used to test this hypothesis by providing the NSAID, aspirin, daily in the feed at 50mg/kg or 250 mg/kg." | 3.80 | Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: evidence from an animal model and a human cohort. ( Alfonso, H; Bill Musk, AW; Lake, RA; Nowak, AK; Olsen, N; Robinson, BW; Robinson, C; Woo, S, 2014) |
| " In this study, taking advantage of the transparency of larval zebrafish, Danio rerio, we assessed cardiovascular toxicity of seven known human cardiotoxic drugs (aspirin, clomipramine hydrochloride, cyclophosphamide, nimodipine, quinidine, terfenadine and verapamil hydrochloride) and two non-cardiovascular toxicity drugs (gentamicin sulphate and tetracycline hydrochloride) in zebrafish using six specific phenotypic endpoints: heart rate, heart rhythm, pericardial edema, circulation, hemorrhage and thrombosis." | 3.80 | Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish. ( Dong, QX; Gao, JM; He, JH; Huang, CJ; Li, CQ; Xu, YQ; Xuan, YX; Yu, HP; Zhu, JJ, 2014) |
| " Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats." | 3.79 | Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. ( Agrawal, M; Madhur, G; Mishra, V; Narender, T; Onasanwo, SA; Palit, G; Pandey, HP; Rastogi, P, 2013) |
| "Adjuvant arthritis was induced in rats with and without prophylactic losartan (AT1R antagonist) treatment." | 3.79 | Angiotensin II Type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis. ( Dunning, L; Ferrell, WR; Lockhart, JC; Mackenzie, A, 2013) |
| "To investigate the effects of long term pretreatment with low-, medium- and high-dose aspirin (acetylsalicylic acid, ASA) on a model of acute pancreatitis (AP) induced in rats." | 3.79 | Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats. ( Akyazi, I; Bala, DA; Cırakli, ZL; Ekiz, EE; Eraslan, E; Gülçubuk, A; Haktanir, D; Matur, E; Ozcan, M; Ozkurt, M, 2013) |
| "We previously demonstrated the pro-metastasis effect of sorafenib in hepatocellular carcinoma (HCC), which is mediated by down-regulation of tumor suppressor HTATIP2." | 3.79 | Aspirin minimized the pro-metastasis effect of sorafenib and improved survival by up-regulating HTATIP2 in hepatocellular carcinoma. ( Ao, JY; Chai, ZT; Kong, LQ; Li, JQ; Lu, L; Sun, HC; Tang, ZY; Wang, L; Wang, WQ; Wu, WZ; Zhang, KZ; Zhang, QB; Zhang, W; Zhang, YY; Zhu, XD, 2013) |
| " Built on these observations, a recent preclinical study took advantage of a previously established hepatitis B virus (HBV) transgenic mouse model of immune-mediated chronic hepatitis that progresses to hepatocellular carcinoma (HCC), to demonstrate that clinically achievable doses of the anti-platelet drugs aspirin and clopidogrel - administered continuously after the onset of liver disease - can prevent hepatocarcinogenesis and greatly improve overall survival." | 3.79 | Anti-platelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma. ( Guidotti, LG; Iannacone, M; Sitia, G, 2013) |
| " Peganine hydrochloride was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats." | 3.79 | Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers. ( Barthwal, MK; Khaliq, T; Mishra, V; Narender, T; Palit, G; Pandey, HP; Singh, VK; Tiwari, S, 2013) |
| " Geniposide and genipin were studied on venous thrombosis by oral administration." | 3.79 | Antithrombotic activities of aqueous extract from Gardenia jasminoides and its main constituent. ( Liu, H; Wei, SF; Yang, M; Zhang, HY, 2013) |
| " Long-term administration of cilostazol is more effective in reducing neointimal formation at non-overlapping segments of BESs in a porcine coronary model." | 3.79 | The impact of triple anti-platelet therapy for endothelialization and inflammatory response at overlapping bioabsorbable polymer coated drug-eluting stents in a porcine coronary model. ( Ahn, Y; Cho, JG; Hong, YJ; Jeong, MH; Kang, JC; Kim, JH; Kim, JM; Kim, KH; Lee, KH; Lim, KS; Park, DS; Park, HW; Park, JC; Park, KH; Sim, DS; Yoon, HJ; Yoon, NS, 2013) |
| "Tumor-associated inflammation is a driving force in several adult cancers and intake of low-dose aspirin has proven to reduce cancer incidence." | 3.79 | Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma. ( Carlson, LM; Idborg, H; Jakobsson, PJ; Kogner, P; Rasmuson, A; Segerström, L; Sveinbjörnsson, B, 2013) |
| "The antinociceptive effects of the EE, CE and EtOAcE of Prosopis strombulifera fruits were evaluated in vivo using the formalin-induced pain test in mice with aspirin and morphine as reference antinociceptive compounds." | 3.78 | Involvement of the L-arginine-nitric oxide pathway in the antinociception caused by fruits of Prosopis strombulifera (Lam.) Benth. ( Bustos, PS; Cabrera, JL; Chiabrando, GA; Ortega, MG; Pierosan, L; Santos, AR; Saragusti, AC, 2012) |
| " We examined the effects on thrombosis and haemostasis in PAR₄ -/- mice (platelets unresponsive to thrombin) treated with therapeutic doses of either aspirin or clopidogrel." | 3.78 | Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice. ( Hamilton, JR; Jackson, SP; Lee, H; Mountford, JK; Sturgeon, SA, 2012) |
| " In normal female rats, the sera total thyroxine (TT4) and total triiodothyronine (TT3) levels were detectably increased at day 10 post-partum than those at day 10 of pregnancy." | 3.78 | Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: II-the developmental pattern of neurons in relation to oxidative stress and antioxidant defense system. ( Abd El-Tawab, SM; Ahmed, OM; Ahmed, RG; El-Bakry, AM; El-Gareib, AW, 2012) |
| "To establish a model of acute lung injury induced by paraquat poisoning and to observe the effects of anticoagulant therapy on acute lung injury induced by paraquat poisoning." | 3.78 | [Experimental anticoagulant therapy of acute lung injury induced by paraquat]. ( Bi, YQ; Jian, XD; Jiang, J; Liu, F; Liu, HM; Niu, YY; Shang, B; Tian, D; Zhang, W; Zhang, ZC; Zhou, Q, 2012) |
| "Our findings show that the use of dipyridamole before testicular reperfusion has a potentially protective effect against long-term injury in testicular ischemia reperfusion injury." | 3.78 | Comparison of the protective effect of dipyridamole and acetylsalicylic acid on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury. ( Karagüzel, E; Kazaz, İO; Kutlu, Ö; Mungan, S; Özgür, GK; Tok, DS; Yuluğ, E, 2012) |
| "Hydrogen sulfide (H(2)S) is a novel gaseous mediator that plays important roles in atherosclerosis." | 3.78 | Effect of S-aspirin, a novel hydrogen-sulfide-releasing aspirin (ACS14), on atherosclerosis in apoE-deficient mice. ( Fan, Y; Gu, T; Guo, C; Sparatore, A; Wang, C; Wu, D; Zhang, A; Zhang, H, 2012) |
| "3 nmol) of lipoxin A4 (LXA4), lipoxin B4 (LXB4) or aspirin-triggered-15-epi-lipoxin A4 (ATL) could alleviate the mechanical allodynia in CIBP on day 7 after surgery." | 3.78 | Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines. ( Hu, S; Huang, YL; Jiang, JW; Mao-Ying, QL; Mi, WL; Wang, J; Wang, XW; Wang, YQ; Wang, ZF; Wu, GC, 2012) |
| "Aspirin is associated with a reduced risk of colorectal cancer (CRC), and it showed inhibited effects on interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway which is thought to play an important role in intestinal inflammation and the tumorigenesis of CRC." | 3.77 | Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway. ( Chen, H; Gao, W; Mao, X; Ren, C; Song, T; Tian, Y; Wang, D; Ye, Y, 2011) |
| " Previous cellular studies showed that aspirin (acetylsalicylic acid: ASA) and nitric oxide-donating ASA (NO-ASA) suppressed microsatellite instability (MSI) in mismatch repair (MMR)-deficient cells linked to the common cancer predisposition syndrome hereditary nonpolyposis colorectal cancer or Lynch syndrome (LS/HNPCC), at doses 300- to 3,000-fold less than ASA." | 3.77 | Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model. ( Bocker-Edmonston, T; Edelmann, W; Fishel, R; Kerepesi, LA; Kopelovich, L; Kucherlapati, MH; Kucherlapati, R; McIlhatton, MA; Tyler, J, 2011) |
| "To explore the therapeutic effects of aspirin on postmenopausal osteoporosis and understand its action mechanism." | 3.77 | [Effect of aspirin administration for the treatment of osteoporosis in ovariectomized rat model]. ( Chen, ZW; Feng, J; Li, XJ; Qin, GL; Sang, HX; Wang, J; Wang, JC; Wang, LS; Wu, ZX; Zhang, D, 2011) |
| "The antithrombotic effect of the glycopreotein IIb/IIIa (GP IIb/IIIa) receptor antagonist Z4A5, exert alone or combination with heparin, and/or aspirin, was examined in a rabbit arteriovenous shunt thrombosis model." | 3.77 | Antithrombotic activity of Z4A5, a new platelet glycoprotein IIb/IIIa receptor antagonist evaluated in a rabbit arteriovenous shunt thrombosis model. ( Jing, BB; Li, YP; Li, YX; Ren, ST; Wang, B; Wang, M; Zang, WJ; Zhang, H, 2011) |
| " Here, we evaluated the influence of aspirin and etodolac, a selective cyclooxygenase-2 inhibitor, on neovascularization using a murine ischemia hind limb model." | 3.76 | The cyclooxygenase-2 selective inhibitor, etodolac, but not aspirin reduces neovascularization in a murine ischemic hind limb model. ( Hisatome, I; Kita, Y; Shimizu, T; Tanaka, K; Tsujimoto, S; Uozumi, N; Yamamoto, Y; Yoshida, A, 2010) |
| "These findings suggest that ASA changes Th17-type into Th2-type inflammation mainly via the adenosine and uric acid metabolic pathway in the lung." | 3.76 | Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. ( Gyu Jeon, S; Kim, YK; Kim, YS; Moon, HG; Oh, SY; Song Gho, Y; Tae, YM; Zhu, Z, 2010) |
| "Effect of various doses (20, 40, 80, 160 and 320 mg/kg, po) of earthworm paste (Lampito mauritii, Kinberg) was studied on aspirin-induced gastric ulcer and compared to ranitidine." | 3.76 | Gastroprotective effect of earthworm paste (Lampito mauritii, Kinberg) on experimental gastric ulcer in rats. ( Gunasekaran, G; Prakash, M, 2010) |
| "5 of pregnancy, each group was respectively treated as follows: a) mice in group C (n = 12, control group) were injected with 100 microl of filtered phosphate-buffered saline into the tail vein every day; b) group PE (n = 15, preeclampsia model group) were injected in the same way with 100 microl of filtered PS/PC vesicle suspension; c) group H (n = 9, group treated with heparin) were injected with 1 unit heparin together with PS/PC vesicle suspension; d) group A (n = 10, group treated with aspirin) were injected with 20 microg/g aspirin-DL lysine as well; e) group LD (n = 10, group treated with low-dose Danshensu) were injected with 10 microg/g Danshensu; and f) group HD (n = 10, group treated with high-dose Danshensu) were injected with 30 microg/g Danshensu." | 3.76 | Effects of Danshensu on maternal syndrome in phosphatidylserine/phosphatidylcholine microvesicle induced-mouse model: is it a candidate for preeclampsia remedy? ( Hu, YL; Shen, Y; Wang, JM; Zhang, Y, 2010) |
| "Combined antiplatelet agents (cAPA), aspirin plus clopidogrel, increase the risk of bleeding." | 3.76 | Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel. ( Bachelot-Loza, C; Dizier, B; Emmerich, J; Gaussem, P; Godier, A; Grelac, F; Hindy-François, C; Le Bonniec, B; Samama, CM, 2010) |
| " The aim of the present study was to examine the effect of chronic administration of aspirin on metabolic and cardiovascular parameters in fructose-fed rats (FFR), an experimental model of metabolic syndrome." | 3.75 | Effect of chronic aspirin administration on an experimental model of metabolic syndrome. ( González, ES; Lama, MC; Miatello, RM; Renna, NF; Vazquez, MA, 2009) |
| "Compared with other non-steroid anti-inflammatory drugs (NSAIDs), aspirin is not correlated to hypertension." | 3.75 | Salicylates dilate blood vessels through inhibiting PYK2-mediated RhoA/Rho-kinase activation. ( Giachini, FR; Tostes, RC; Webb, RC; Ying, Z, 2009) |
| "6% of 10 ml) induced pain and the effects were also compared to aspirin, morphine and naloxone while formalin induced pain (0." | 3.75 | Antinociceptive activity of Amaranthus spinosus in experimental animals. ( Amresh, G; Rao, CV; Singh, S; Zeashan, H, 2009) |
| "Although decursinol, which is one of the coumarins purified from the dried roots of Angelica gigas Nakai, was previously demonstrated to have antinociceptive effects on various mouse pain models such as tail-flick, hot-plate, formalin, writhing, and several cytokine-induced pain tests, the possible involvement of its analgesic effects and non-steroidal anti-inflammatory drugs (NSAIDs) has not been clearly elucidated yet." | 3.75 | The analgesic effect of decursinol. ( Choi, SM; Huh, GH; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Sim, YB; Suh, HW, 2009) |
| "Atherosclerosis being considered as an inflammatory disorder, the present study was undertaken to investigate the effectiveness of anti-inflammatory drugs (ibuprofen, aspirin, and celecoxib) in hypercholesterolemia." | 3.74 | Antiatherosclerotic activity of ibuprofen, a non-selective COX inhibitor--an animal study. ( Dabhi, JK; Mehta, A; Solanki, JK, 2008) |
| "The ethanol extract of Toona ciliata Roemer (heart wood) was evaluated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer (antisecretory), HCl-ethanol induced ulcer (cytoprotective) and water immersion stress induced ulcer in rats." | 3.74 | Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood). ( Gopalakrishnan, G; Kavimani, S; Malairajan, P; Narasimhan, S; Veni, KJ, 2007) |
| "Aspirin (acetylsalicylic acid) or ibuprofen [2-(4-isobutyl-phenyl)-propionic acid] was administered to mice undergoing treatment of tuberculosis infection with pyrazinamide to determine if these non-steroidal anti-inflammatory drugs (NSAIDs) enhance pyrazinamide activity in vivo." | 3.74 | Aspirin and ibuprofen enhance pyrazinamide treatment of murine tuberculosis. ( Byrne, ST; Denkin, SM; Zhang, Y, 2007) |
| "The results suggest that triflusal and aspirin appear to be equally neuroprotective against middle cerebral artery occlusion-induced cerebral ischemia." | 3.74 | Effects of triflusal and aspirin in a rat model of cerebral ischemia. ( Allen, GV; Bayona, NA; Cechetto, DF; Cheng, G; Hachinski, VC; Whitehead, SN, 2007) |
| "Continuous aspirin treatment (120 mg/kg/d) reduces the expression of proinflammatory cytokines after myocardial infarction, but does not affect post-infarct cardiac remodeling and cardiac function." | 3.74 | High dose aspirin and left ventricular remodeling after myocardial infarction: aspirin and myocardial infarction. ( Adamek, A; Bauersachs, J; Bayer, B; Ertl, G; Frantz, S; Hu, K; Wagner, H, 2007) |
| "The present study was carried out to investigate the effect of the combination of an endothelin antagonist TAK-044 and an antiinflammatory agent aspirin in middle cerebral artery (MCA) occlusion model of acute ischemic stroke in rats." | 3.74 | Effect of combination of endothelin receptor antagonist (TAK-044) and aspirin in middle cerebral artery occlusion model of acute ischemic stroke in rats. ( Briyal, S; Gulati, A; Gupta, YK, 2007) |
| " Fibrin(ogen) deposition, light transmittance aggregometry (LTA; collagen, U46619, and ADP), and bleeding time (BT) were also evaluated." | 3.74 | A thromboxane A2/prostaglandin H2 receptor antagonist (S18886) shows high antithrombotic efficacy in an experimental model of stent-induced thrombosis. ( Badimon, L; Casaní, L; Vilahur, G, 2007) |
| "Aspirin is a common preventative therapy in patients at risk for cardiovascular diseases, yet little is known about how aspirin protects the vasculature in hypercholesterolemia." | 3.74 | Roles of platelet and endothelial cell COX-1 in hypercholesterolemia-induced microvascular dysfunction. ( Granger, DN; Specian, RD; Tailor, A; Wallace, JL; Wood, KC, 2007) |
| "Acetylsalicylic acid (ASA) and the thienopyridine clopidogrel are established anti-platelet drugs that significantly reduce secondary cardiovascular events in patients with manifest atherosclerosis." | 3.74 | Effect of chronic treatment with acetylsalicylic acid and clopidogrel on atheroprogression and atherothrombosis in ApoE-deficient mice in vivo. ( Koellnberger, M; Konrad, I; Lorenz, R; Massberg, S; Orschiedt, L; Sauer, S; Schulz, C; Walter, U, 2008) |
| "The objective of this study was to determine if orally-administered PD0348292, a direct specific factor Xa inhibitor, inhibits thrombosis following porcine carotid arterial injury comparably to aspirin or clopidogrel alone or in combination." | 3.74 | Comparison of PD0348292, a selective factor Xa inhibitor, to antiplatelet agents for the inhibition of arterial thrombosis. ( Baxi, S; Karnicki, K; Leadley, RJ; McBane, RD; Peterson, T; Wysokinski, W, 2008) |
| "At a similar level of efficacy in inhibiting secondary thrombosis, triflusal seems to better preserve Cox-2 expression than aspirin and its metabolite HTB was able to protect endothelial prostacyclin production." | 3.74 | Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2. ( Badimon, L; Duran, X; Sánchez, S; Vilahur, G, 2008) |
| " The extract at 400 mg/kg body weight, once daily, orally has a significant effect in cold restraint (CRU, 2 h cold restraint stress), aspirin (ASA, 150 mg/kg body weight, orally), alcohol (AL, 1 ml/200 gm of absolute alcohol) and pyloric ligation (PL, 4h ligation) induced gastric ulcer models as it showed protection index of 71." | 3.73 | Allophylus serratus: a plant with potential anti-ulcerogenic activity. ( Dharmani, P; Maurya, R; Mishra, PK; Palit, G; Singh Chauhan, V, 2005) |
| " albicans and vehicle inoculation on gastric secretion and healing of gastric ulcers induced by acetic acid in rats treated with 1) ranitidine (30 mg kg(-1) day(-1) s." | 3.73 | Influence of gastric colonization with Candida albicans on ulcer healing in rats: effect of ranitidine, aspirin and probiotic therapy. ( Bogdal, J; Brzozowski, T; Budak, A; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Kwiecien, S; Pawlik, WW; Stachura, J; Zwolinska-Wcislo, M, 2005) |
| "COX-1-dependent eicosanoid formation accelerates atherogenesis, and low-dose aspirin reduces early atherosclerosis." | 3.73 | Stabilization of advanced atherosclerosis in low-density lipoprotein receptor-deficient mice by aspirin. ( Cyrus, T; Praticò, D; Tung, LX; Yao, Y, 2006) |
| " Gaultherin, 2-[(6-O-beta-D-Xylopyranosyl-beta-D-glucopyranosyl)oxy] benzoic acid methyl ester, a natural salicylate derivative extracted from Gaultheria yunnanensis, has been shown to have analgesic and anti-inflammatory effects and lack gastric ulcerogenic effect compared to aspirin in our primary study." | 3.73 | Gaultherin, a natural salicylate derivative from Gaultheria yunnanensis: towards a better non-steroidal anti-inflammatory drug. ( Ding, Y; Du, GH; He, XL; Zhang, B, 2006) |
| "Reactive oxygen species, neutrophil infiltration and proinflammatory cytokines play an important role in the pathogenesis of gastric ulcers caused by aspirin." | 3.73 | Attenuation of neutrophil infiltration and proinflammatory cytokines by Cissus quadrangularis: a possible prevention against gastric ulcerogenesis. ( Jainu, M; Shyamala Devi, CS, 2005) |
| "To investigate the possible effects of nuclear factor-KappaB (NF-KappaB) activation on the expression of intercellular adhesion molecular-1 (ICAM-1) and P-selectin in murine acute lung injury (ALI) and assess the potential beneficial effects and mechanism of low molecular weight heparin (LMWH) and aspirin (ASA)." | 3.73 | [Therapeutic effects of low molecular weight heparin and aspirin on acute lung injury in rat]. ( Luan, ZG; Ma, XC; Nala, P; Zhang, ZD, 2006) |
| " Cardiac lesions induced by isoproterenol (ISO) are characterized by myocardial necrosis and exudative infiltration." | 3.72 | Effect of D-003 on isoproterenol-induced myocardial necrosis in rats. ( Arruzazabala, ML; Carbajal, D; González, J; Más, R; Mendoza, S; Molina, V; Noa, M, 2003) |
| "Using automatic erythrocyte aggregometer type MA-1 (Myrenne gmbh, Germany), we investigated the hypothesis that therapeutic effectiveness of quinapril--angiotensin converting enzyme inhibitor (ACEI)--in the treatment of hypertension would correlate with improvement of red blood cell (RBC) aggregability." | 3.72 | Secretory dysfunction of vascular endothelium limits the effect of angiotensin converting enzyme inhibitor quinapril on aggregation of erythrocytes in experimental hypertension. ( Adamek-Guzik, T; Korbut, R; Korbut, RA; Madej, J, 2003) |
| "To investigate the protective effects and mechanism of action of aspirin on focal cerebral ischemia-reperfusion rats." | 3.72 | [Protective effects and mechanism of action of aspirin on focal cerebral ischemia-reperfusion in rats]. ( Chen, CH; Qiu, LY; Yu, J; Zhou, Y, 2003) |
| "Gastric ulcers were induced in Wistar rats (male, 200 +/- 25 g), by 150 mg/kg acidified aspirin application." | 3.72 | The role of transforming growth factor alpha formulation on aspirin-induced ulcer healing and oxidant stress in the gastric mucosa. ( Akbulut, KG; Celebi, N; Gönül, B; Ozer, C; Yetkin, G, 2004) |
| "The aim of this study is to assess the role of high fibre diet and aspirin on dimethylhydrazine (DMH)-induced colorectal cancer in rats." | 3.72 | The effect of aspirin and high fibre diet on colorectal carcinoma: a comparative experimental study. ( Kiskinis, D; Miliaras, D; Miliaras, S; Vrettou, E; Zavitsanakis, A, 2004) |
| "Chronic in vivo treatment with aspirin prevented the development of hypertension and reduced insulin resistance significantly in chronically glucose-fed rats." | 3.71 | Prevention of hypertension, hyperglycemia and vascular oxidative stress by aspirin treatment in chronically glucose-fed rats. ( de Champlain, J; El Midaoui, A; Wu, R, 2002) |
| "The present study was designed to evaluate the effects of a potassium channel opener, nicorandil, and to elucidate its possible mechanism of action in aspirin plus pylorus ligation induced and ethanol-induced gastric ulcers in rats." | 3.71 | Evaluation of the effects of nicorandil on experimentally induced gastric ulcers. ( Goswami, SG; Patel, HM; Santani, DD, 2001) |
| " We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat." | 3.71 | Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001) |
| "9), when given in the dose of 10-50 mg/kg, twice daily for 5 days, showed dose-dependent anti-ulcerogenic on various gastric ulcer models induced by ethanol, aspirin, 2 h cold restraint stress and 4 h pylorus ligation." | 3.71 | Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. ( Babu, MD; Goel, RK; Rao, CV; Sairam, K, 2001) |
| "In this model of chronic inflammation, aspirin, more selective for the inhibition of COX-1 is more effective than the selective COX-2 inhibitors nimesulide and NS-398 at inhibiting granuloma dry weight, vascularity and COX activity." | 3.70 | Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation. ( Gilroy, DW; Tomlinson, A; Willoughby, DA, 1998) |
| "In this study the severity of aspirin-induced gastric mucosal damage was investigated in rats with obstructive cholestasis." | 3.70 | Enhancement of aspirin-induced gastric damage by cholestasis in rats. ( Alikhani, Z; Dehpour, AR; Ghaffari, K; Mani, AR; Nowroozi, A; Sabbagh, B; Sadr, S; Sharif, A; Toor Savadkoohi, S; Zeinoddini, M, 1998) |
| "Isoproterenol hydrochloride (ISO), a beta adrenergic agonist, is known to cause ischemic necrosis in rats." | 3.70 | Effect of a novel tetrapeptide derivative in a model of isoproterenol induced myocardial necrosis. ( Jayakumar, R; Jayasundar, S; Malarvannan, P; Puvanakrishnan, R; Ramesh, CV, 1998) |
| "Diaspirin cross-linked hemoglobin (DCLHb) is a vasoactive hemoglobin-based oxygen carrier or "blood substitute" that has been shown to improve base deficit in several experimental studies of hemorrhagic shock." | 3.70 | The effects of diaspirin cross-linked hemoglobin on hemodynamics, metabolic acidosis, and survival in burned rats. ( Hansbrough, JF; Soltero, RG, 1999) |
| "To evaluate the effect of singular or sustained hemodilution, with alpha-alpha diaspirin crosslinked hemoglobin (DCLHb), on the area of hypoperfusion after subarachnoid hemorrhage." | 3.70 | Subarachnoid hemorrhage in rats: effect of singular or sustained hemodilution with alpha-alpha diaspirin crosslinked hemoglobin on cerebral hypoperfusion. ( Cole, DJ; Drummond, JC; Jacobsen, WK; Nary, JC; Patel, PM; Reynolds, LW, 1999) |
| "Aspirin has a well established role in the prevention of arterial thrombosis." | 3.70 | Time related neutralization of two doses acetyl salicylic acid. ( Aguejouf, O; Belon, P; Doutremepuich, C; Malfatti, E, 2000) |
| "A series of 2-substituted- and 2,3-disubstituted-4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-1H- pyrroles was synthesized and found to be active in the rat adjuvant arthritis model of inflammation." | 3.69 | Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR. ( Galbraith, W; Gans-Brangs, K; Grubb, M; Hewes, WE; Jaffee, B; Kenney, JP; Kerr, J; Wilkerson, WW; Wong, N, 1994) |
| "Anti-ulcerogenic activity of the methanolic extracts of 4 medicinal plants were studied in aspirin-induced gastric ulcers in rats." | 3.69 | Anti-ulcerogenic evaluation of the methanolic extracts of some indigenous medicinal plants of Pakistan in aspirin-ulcerated rats. ( Ahmad, KU; Akhtar, AH, 1995) |
| "This study examined the effect of low dose aspirin on cardiorenal and neurohumoral function and on the acute hemodynamic response to enalaprilat in a canine model of heart failure." | 3.69 | Effect of low dose aspirin on cardiorenal function and acute hemodynamic response to enalaprilat in a canine model of severe heart failure. ( Burnett, JC; Evans, MA; Redfield, MM, 1995) |
| "Adding NTG to a thrombolytic regimen with rt-PA, aspirin and heparin increases the magnitude of restored flow and total patency duration following recanalization in a rabbit model of arterial thrombosis." | 3.69 | Beneficial effect of nitroglycerin on arterial rethrombosis after thrombolysis. Results from a rabbit thrombosis model. ( Battler, A; Chernine, A; Hasdai, D; Kornowski, R; Ovadia, Z, 1995) |
| " Neither indomethacin nor aspirin showed any effect in preventing osteoarthritis progression." | 3.69 | An experimental model of osteoarthritis in rabbit. ( Chang, DM; Chang, ML; Chen, CM; Chu, SJ; Hsu, CM; Kuo, SY, 1994) |
| "Hirulog, a thrombin-specific inhibitor, has shown efficacy in reducing arterial thrombosis in patients treated with aspirin who require angioplasty or have unstable angina." | 3.69 | Inhibition of platelet deposition by combined hirulog and aspirin in a rat carotid endarterectomy model. ( Alving, BM; Barr, CF; Gomez, ER; Hamelink, JK; Jackson, MR; Reid, TJ; Tang, DB, 1995) |
| " Using a described model of microarterial thrombosis, the antithrombotic effects of oral aspirin (ASA) were assessed in rats." | 3.69 | The role of various antithrombotic agents in microvascular surgery. ( Buckley, RC; Das, SK; Davidson, SF, 1994) |
| "To examine the effects of aspirin on the oesophageal mucosa and on acid- and pepsin-induced oesophagitis." | 3.69 | Aspirin renders the oesophageal mucosa more permeable to acid and pepsin. ( Blas, JM; Esteva, F; Lanas, AI; Ortego, J; Sáinz, R; Soria, J; Sousa, FL, 1995) |
| "Aspirin, when compared to placebo and controls, significantly increased muscle interstitial oedema when given orally and intravenously." | 3.69 | Aspirin increases tissue oedema after skeletal muscle ischaemia and reperfusion. ( Braithwaite, BD; Earnshaw, JJ; Gelabert, H; Moore, WS; Petrik, PV; Pollen, DN; Quinones-Baldrich, WJ, 1996) |
| "Inogatran (MW 439 Da), a new, selective, active site inhibitor of thrombin, was evaluated in three rat models of thrombosis." | 3.69 | Effects of inogatran, a new low-molecular-weight thrombin inhibitor, in rat models of venous and arterial thrombosis, thrombolysis and bleeding time. ( Börjesson, I; Elg, M; Gustafsson, D; Lenfors, S; Teger-Nilsson, AC, 1996) |
| "We determined the effects of aspirin and a novel thromboxane A2/prostaglandin endoperoxide (TP)-receptor antagonist, BMS-180291, on thrombosis and bleeding times in skin and mesenteric arteries." | 3.68 | Superior activity of a thromboxane receptor antagonist as compared with aspirin in rat models of arterial and venous thrombosis. ( Heran, CL; Ogletree, ML; Schumacher, WA; Steinbacher, TE; Youssef, S, 1993) |
| "The antithrombotic effects of the thromboxane (TX) A2-receptor antagonist and aspirin were determined using a photochemically-induced arterial thrombosis model in the femoral arteries of guinea pigs." | 3.68 | Inhibitory effect of KW-3635, a new thromboxane A2-receptor antagonist, on arterial thrombosis in guinea pigs. ( Higo, K; Karasawa, A, 1993) |
| " Administration of bFGF (3-300 micrograms/kg/day) by an intragastric or an intraperitoneal route or sucralfate (400 mg/kg/day) orally to rats with acetic acid induced gastric ulcers, enhanced the healing rate of these ulcers during seven day treatment in a dose dependent manner." | 3.68 | Fibroblast growth factor in gastroprotection and ulcer healing: interaction with sucralfate. ( Bielanski, W; Brzozowski, T; Konturek, SJ; Majka, J; Otto, W; Stachura, J; Szlachcic, A, 1993) |
| "This model of arterial thrombosis induced by laser was used to evaluate the effect of aspirin (Aspegic) on embolization." | 3.68 | Effects of aspirin on embolization in an arterial model of laser-induced thrombus formation. ( Doutremepuich, C; Doutremepuich, F; Lalanne, MC; Vesvres, MH, 1993) |
| "The effects of hemorrhagic shock, aspirin, and ethanol on the biochemical and morphologic changes of experimental pancreatitis were evaluated." | 3.68 | Effects of hemorrhagic shock, aspirin, and ethanol on secretagogue-induced experimental pancreatitis. ( Leli, U; Printz, H; Saluja, A; Sengupta, A; Steer, M, 1990) |
| "The ouabain threshold to induce cardiac arrhythmias in urethane-anaesthetized guinea-pigs was not modified by the administration of either dazmegrel, 4 mg/kg i." | 3.68 | Protective effects of dazmegrel on the PAF potential of ouabain-induced cardiac arrhythmias. ( Barrigón, S; Salinas, P, 1991) |
| " Of the 21 compounds prepared, two were found to be one-tenth as potent as indomethacin in the pleurisy model and one compound was tested and found to be weakly active in the adjuvant arthritis model." | 3.67 | Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives. ( Sancilio, LF; Sleevi, MC; Walsh, DA, 1984) |
| "Trimipramine, a tricyclic antidepressant, significantly inhibited the development of experimental gastric ulcers induced by various methods like stress, drug (aspirin, reserpine) and Shay's pyloric ligation in an inbred strain of albino rats." | 3.67 | Antiulcer effects of trimipramine using various laboratory models. ( Aguwa, CN; Ramanujam, TR, 1984) |
| "The intravenous administration of either aspirin, (in doses of 1 and 3 mg/kg) sodium meclofenamate (1 and 3 mg/kg) or indomethacin (1 and 3 mg/kg) markedly reduced ventricular arrhythmias (VT and VF) induced by coronary artery ligation in anaesthetised rats." | 3.67 | The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats. ( Fagbemi, SO, 1984) |
| "Cardiovascular responses to the calcium antagonist nifedipine, alone and combined with low dose acetylsalicyclic acid (ASA), were evaluated in a piglet model of endotoxin-induced pulmonary hypertension." | 3.67 | The effect of nifedipine alone or combined with low dose acetylsalicyclic acid on endotoxin-induced pulmonary hypertension in the piglet. ( Huth, RG; Jüngst, BK; Schranz, D; Stopfkuchen, H, 1988) |
| "The effects of ticlopidine and aspirin on endotoxin-induced experimental disseminated intravascular coagulation (DIC) were studied in rats." | 3.66 | Effects of ticlopidine and aspirin on endotoxin-induced disseminated intravascular coagulation in rats. ( Furukawa, Y; Kondo, M; Murakami, M; Takemura, S; Yoshikawa, T, 1983) |
| "The anti-inflammatory effect of single doses and combinations of aspirin and commonly used nonsteroidal anti-inflammatory drugs was investigated by the polyurethane sponge implantation model of acute inflammation." | 3.66 | Assessment of nonsteroidal anti-inflammatory drug combinations by the polyurethane sponge implantation model in the rat. ( Brooks, PM; Garrett, R; Manthey, B; Vernon-Roberts, B, 1983) |
| " 9 The results are also discussed in relation to the genesis of aspirin-induced asthma in man." | 3.66 | Spontaneous activity in the trachea of dogs treated with indomethacin: an experimental model for aspirin-related asthma. ( Ito, Y; Tajima, K, 1981) |
| "The effects of cimetidine, a new histamine H2-receptor antagonist, on the development of experimental gastric and duodenal ulcers were studied." | 3.65 | Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. ( Okabe, S; Takagi, K; Takeuchi, K; Urushidani, T, 1977) |
| "Breast cancer is the most ubiquitous type of neoplasms among women worldwide." | 2.66 | Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions. ( Manoharan, R; Natarajan, SR; Ponnusamy, L; Thangaraj, K, 2020) |
| "Aspirin is a generally well-tolerated drug that is now widely used in aged patients for its antithrombotic action." | 2.55 | Aspirin treatment for chronic wounds: Potential beneficial and inhibitory effects. ( Darby, IA; Weller, CD, 2017) |
| "Inflammation has become a research hotspot in solid tumours and has been confirmed as a key factor in tumour development through the interactions of inflammatory mediators with gene expression, cell proliferation, and apoptosis." | 2.49 | Aspirin: a potential therapeutic approach in pancreatic cancer. ( Chen, C; Duan, W; Han, L; Li, P; Li, W; Ma, Q; Ma, Z; Shen, X; Xu, Q; Yu, S; Zhang, L, 2013) |
| "Enlargement of an abdominal aortic aneurysm (AAA) is usually associated with the development of an intraluminal mural thrombus (ILT)." | 2.49 | Anti-platelet treatment of middle-sized abdominal aortic aneurysms. ( Björck, M; Lindholt, JS; Michel, JB, 2013) |
| "Antiphospholipid syndrome is one of the few treatable causes of pregnancy loss, and successful pregnancy rates of 70% or more can be achieved with appropriate treatment." | 2.44 | [Pregnancy and antiphospholipid antibodies]. ( Goffinet, F; Le Guern, V, 2008) |
| "Fondaparinux has not shown any impairment in vitro." | 2.44 | The effect of anticoagulant pharmacotherapy on fracture healing. ( Cockbain, AJ; El Masry, MA; Katonis, P; Lindner, T; Schizas, C; Tsiridis, E, 2008) |
| "The relative risk of colorectal cancer is about 0." | 2.41 | Nonsteroidal anti-inflammatory drugs and the gastrointestinal tract. Extent, mode, and dose dependence of anticancer effects. ( Sjödahl, R, 2001) |
| "Normal pregnancy is characterized by a marked reduction in peripheral vascular resistance." | 2.40 | Hypertension in pregnancy. ( Bernheim, J, 1997) |
| " Chronic administration of aspirin alone over 18 to 68 weeks in doses of 120 to 500 mg/kg/d has been reported to cause renal papillary necrosis in rats." | 2.39 | Does aspirin cause acute or chronic renal failure in experimental animals and in humans? ( D'Agati, V, 1996) |
| "Food allergy is one of the major existing health problems, but no effective treatment is available." | 1.91 | A Murine Model of Food Allergy by Epicutaneous Adjuvant-Free Allergen Sensitization Followed by Oral Allergen Challenge Combined with Aspirin for Enhanced Detection of Hypersensitivity Manifestations and Immunotherapy Monitoring. ( Fujisawa, T; Kameda, K; Kido, H; Kimoto, T; Morita, R; Nagao, M; Sakai, S; Takahashi, E, 2023) |
| "Aspirin (50 mg/kg) was administered on postoperative days (PODs) one and two via oral gavage." | 1.72 | Aspirin Administration Mitigates Platelet Hyperaggregability After Splenectomy in a Murine Model. ( Baucom, MR; England, L; Goodman, MD; Pritts, TA; Schuster, R; Turner, K; Wallen, TE; Youngs, J, 2022) |
| "UVR promotes skin cancer through multiple mechanisms, including induction of inflammation, oxidative stress, and DNA damage such as 8-oxoguanine and cyclobutane pyrimidine dimers." | 1.62 | Aspirin Protects Melanocytes and Keratinocytes against UVB-Induced DNA Damage In Vivo. ( Boucher, KM; Burd, CE; Florell, SR; Grossman, D; Kumar, D; Liu, T; Lum, D; Okwundu, N; Rahman, H; VanBrocklin, MW, 2021) |
| "Fibrosis was significantly less in treated mice atria." | 1.62 | Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation. ( Dixit, G; Li, Z; Ozcan, C, 2021) |
| "Animals without steatosis (ie NAFLD) at week 16 were excluded from the data analysis." | 1.62 | The effect of acetylsalicylic acid and pentoxifylline in guinea pigs with non-alcoholic steatohepatitis. ( Andersen, M; Buelund, LE; Ipsen, DH; Latta, M; Lintrup, K; Lykkesfeldt, J; Skaarup, R; Skat-Rørdam, J; Svenningsen, M; Tveden-Nyborg, P, 2021) |
| "The degree of neovascularization, thrombus, calcification, inflammatory infiltrates, and fibrosis were analyzed histopathologically by hematoxylin and eosin staining." | 1.62 | Anti-thrombotic and anti-inflammatory activity of sulodexide compared to aspirin in the rat model. ( Jo, WM; Kim, JW; Kim, TS; Sohn, SH; Yoo, SM, 2021) |
| "Tendinopathy is a common musculoskeletal system disorder in sports medicine, but regeneration ability of injury tendon is limited." | 1.56 | Aspirin promotes tenogenic differentiation of tendon stem cells and facilitates tendinopathy healing through regulating the GDF7/Smad1/5 signaling pathway. ( Bian, X; Chen, W; He, G; Kang, X; Lyu, J; Mu, M; Shi, Y; Tang, H; Tang, K; Wang, Y; Yang, M; Yuan, C; Zhang, J; Zhou, B; Zhou, M; Zhu, M, 2020) |
| " Therefore, the goal of this paper was to create a physiologically based pharmacokinetic (PBPK) model to offer a reasonable starting point for required total AT-RvD1 dosage to be administered in future mice and humans thereby eliminating the need for excessive use of animals and humans in preclinical and clinical trials, respectively." | 1.56 | Predictive modeling of aspirin-triggered resolvin D1 pharmacokinetics for the study of Sjögren's syndrome. ( Baker, OJ; Yellepeddi, VK, 2020) |
| " ASA treatment also evoked an increase in platelet and granulocyte counts and decreased systemic NO bioavailability along with increased markers of systemic oxidant stress such as higher GSSG/lower GSH concentrations in RBC." | 1.56 | Unexpected effects of long-term treatment with acetylsalicylic acid on late phase of pulmonary metastasis in murine model of orthotopic breast cancer. ( Berkowicz, P; Chlopicki, S; Derszniak, K; Jasztal, A; Kieronska-Rudek, A; Kij, A; Matyjaszczyk-Gwarda, K; Proniewski, B; Przyborowski, K; Smeda, M; Sternak, M; Stojak, M, 2020) |
| "The presence or absence of thrombus in the vein graft samples was recorded under light microscopy." | 1.56 | Drug-eluting Vein Graft with Acetylsalicylic Acid-Ticagrelor-Unfractionated Heparin Complex Inhibits Early Graft Thrombosis ( Akşit, E; Büyük, B; Çokkalender, Ö; Kurt, T, 2020) |
| "Neonatal ischemic stroke has a higher incidence than childhood stroke." | 1.56 | Preventive Effects of Neuroprotective Agents in a Neonatal Rat of Photothrombotic Stroke Model. ( Choi, SG; Kang, JW; Kim, DW; Kim, SK; Shin, HJ; Song, HJ; Yi, YY, 2020) |
| "Melanoma is the most aggressive and fatal type of skin cancer due to being highly proliferative." | 1.56 | Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis. ( Abou-Kheir, W; Ausina, P; Branco, JR; Demaria, TM; Esteves, AM; Leandro, JGB; Mendonça, APM; Ochioni, AC; Oliveira, MF; Palhano, FL; Sola-Penna, M; Zancan, P, 2020) |
| "Gallbladder stones (cholecystolithiasis) are the main risk factor for gallbladder cancer (GBC), a lethal biliary malignancy with poor survival rates worldwide." | 1.56 | Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia. ( Arrese, M; Bizama, C; Espinoza, JA; Ferreccio, C; García, P; Gómez, N; González, X; Guevara, F; Kalergis, AM; Lobos-González, L; Miquel, JF; Muñoz-Durango, N; Roa, JC; Rosa, L; Saavedra, N; Villegas, J; Wichmann, IA, 2020) |
| "Aspirin was injected intraperitoneally twice daily for 11 days." | 1.51 | Aspirin alleviates orthopedic implant‑associated infection. ( Jiang, Y; Lin, JC; Qin, HJ; Ren, ML; Wang, SN; Wu, HT; Yu, B, 2019) |
| "Aspirin treatment also had favorable therapeutic effects on bone regeneration in the bone defect model, and the number of osteoclasts was decreased." | 1.51 | Aspirin inhibits RANKL-induced osteoclast differentiation in dendritic cells by suppressing NF-κB and NFATc1 activation. ( Bai, Y; Du, J; Guo, L; Jia, L; Jiang, Y; Liu, Y; Luo, Z; Wu, L, 2019) |
| " We used femtosecond laser ablation to rupture arterioles in the cortex of both young (2-5 months old) and aged (18-29 months old) mice dosed on aspirin in their drinking water and measured the extent of penetration of both red blood cells and blood plasma into the surrounding tissue." | 1.51 | Aspirin treatment does not increase microhemorrhage size in young or aged mice. ( Brophy, M; Chan, S; Nishimura, N; Schaffer, CB, 2019) |
| "Aspirin plays an important role in the prevention and therapy of pre-eclampsia." | 1.51 | Ameliorative effects of pre-eclampsia by quercetin supplement to aspirin in a rat model induced by L-NAME. ( Ma, Y; Shi, X; Song, L; Yang, S; Zhao, N, 2019) |
| "Aspirin eugenol ester (AEE) is a novel compound that is formed from the esterification of aspirin (acetylsalicylic acid (ASA)) and eugenol." | 1.51 | UPLC-Q-TOF/MS-Based Plasma Metabolomics to Evaluate the Effects of Aspirin Eugenol Ester on Blood Stasis in Rats. ( Jiao, Z; Kong, X; Li, J; Li, S; Liu, X; Ma, N; Qin, Z; Shen, D; Yang, Y, 2019) |
| "Aspirin treatment suppressed toll‑like receptor (TLR)4 and nuclear factor (NF)‑κB expression in cerebrovascular endothelial cells." | 1.48 | Aspirin ameliorates cerebral infarction through regulation of TLR4/NF‑κB‑mediated endoplasmic reticulum stress in mouse model. ( Cui, X; Shen, B; Sun, D; Wang, X, 2018) |
| "Aspirin pretreatment prevented the diffuse thrombosis of cortical and subcortical vessels after aSDH." | 1.48 | Direct visualization of microcirculation impairment after acute subdural hemorrhage in a novel animal model. ( Hsieh, ST; Huang, SJ; Lee, JE; Lin, WC; Po-Hao Huang, A; Tsai, JC; Wang, HC; Wang, KC, 2018) |
| "Mild hyperhomocysteinemia is considered a risk factor for development of neurodegenerative diseases." | 1.48 | Chronic Mild Hyperhomocysteinemia Alters Inflammatory and Oxidative/Nitrative Status and Causes Protein/DNA Damage, as well as Ultrastructural Changes in Cerebral Cortex: Is Acetylsalicylic Acid Neuroprotective? ( de S Moreira, D; Figueiró, PW; Guma, FCR; Manfredini, V; Prezzi, CA; Rohden, F; Siebert, C; Wyse, ATS, 2018) |
| "To explore the preventive and therapeutic effects of Resveratrol combined with total flavones of hawthorn, compatibility of traditional Chinese medicines, on the endothelial cells injury after artery bypass graft surgery." | 1.48 | Resveratrol combined with total flavones of hawthorn alleviate the endothelial cells injury after coronary bypass graft surgery. ( Feng, B; He, S; Su, Z; Zheng, G; Zhu, Y, 2018) |
| "Aspirin 100 mg/kg was used as a positive control." | 1.48 | Methanolic Extract of Leathery Murdah, Terminalia coriacea (Roxb.) Wight and Arn. Leaves Exhibits Anti-Inflammatory Activity in Acute and Chronic Models. ( Al-Sanea, MM; Gamal Mahmoud, M; Khatoon, N; Rahman, HU; Safwan Ali Khan, M, 2018) |
| "extract is traditionally used for the treatment of inflammation, bronchopneumonia, feverish pains, and breast cancer." | 1.48 | The new plant Parinari kerstingii Engl.: Toxicity studies and anti-inflammatory properties. ( Alolga, RN; Hanson, C; Linus, LO; Liu, Q; Lu, YT; Njokuocha, RC; Qi, LW; Shi, N; Wang, SL, 2018) |
| "Preeclampsia is a severe pregnancy-related disorder, and patients usually present with high circulating inflammatory factor levels and excessive activation of the nuclear factor-κB (NF-κB) pathway." | 1.48 | The intervention effect of aspirin on a lipopolysaccharide-induced preeclampsia-like mouse model by inhibiting the nuclear factor-κB pathway. ( Li, G; Lin, L; Ma, L; Wang, YL; Yang, H, 2018) |
| "Non-alcoholic fatty liver disease (NAFLD) is now a public health issue worldwide, but no drug has yet received approval." | 1.48 | Genistein Ameliorates Non-alcoholic Fatty Liver Disease by Targeting the Thromboxane A ( Chen, J; Chen, W; Li, H; Mao, J; Wang, M; Wang, W; Zhang, H, 2018) |
| "Aspirin treatment significantly decreased the levels of pro-inflammatory cytokines in serum and placenta tissues of preeclampsia rats." | 1.48 | Ameliorative effects of aspirin against lipopolysaccharide-induced preeclampsia-like symptoms in rats by inhibiting the pro-inflammatory pathway. ( Liu, F; Lu, X; Sun, J; Tang, D; Zhang, H, 2018) |
| " Administration of ASA increased the infarct severity; however, concomitant dosing with NTG somewhat attenuated this effect." | 1.48 | Nitroglycerin application and coronary arteriogenesis. ( Bramlage, P; Buschmann, IR; Dawid, R; Dülsner, A; Gatzke, N; Gorath, M; Güc, N; Hillmeister, P; Pagonas, N; Smith, KH, 2018) |
| "Aspirin eugenol ester (AEE) is a novel compound that exhibits efficacious anti-hyperlipidemia activities." | 1.48 | Aspirin eugenol ester regulates cecal contents metabolomic profile and microbiota in an animal model of hyperlipidemia. ( Jiao, ZH; Kong, XJ; Li, JY; Li, SH; Liu, XW; Ma, N; Qin, Z; Yang, YJ, 2018) |
| "Aspirin treatment during the acute phase of infection reduced parasitemia (P<." | 1.46 | Myenteric neuroprotective role of aspirin in acute and chronic experimental infections with Trypanosoma cruzi. ( Araújo, EJA; Araújo, SM; Belém, MO; Buttow, NC; Carlos, TM; Gouveia, R; Luchetti, BFC; Massocatto, CL; Moreira, NM; Oda, JY; Pinge-Filho, P; Sant Ana, DMG, 2017) |
| "Thioacetamide (TAA) was used to induce liver fibrosis in the model group." | 1.46 | Effects of aspirin and enoxaparin in a rat model of liver fibrosis. ( Li, CJ; Liu, DL; Shi, XL; Yang, ZH, 2017) |
| "Thus treatment with aspirin in the chronic phase of Chagas' disease changes the natural history of the disease and raises the possibility of using it as a new therapeutic approach to the treatment of this aspect of Chagas' disease pathology." | 1.46 | Treatment with low doses of aspirin during chronic phase of experimental Chagas' disease increases oesophageal nitrergic neuronal subpopulation in mice. ( de Almeida Araújo, EJ; de Mello Gonçales Sant'ana, D; Marques de Araújo, S; Martins Moreira, N; Massocatto, CL; Muniz, E; Pinge-Filho, P; Rossi, RM, 2017) |
| "Polychlorinated dibenzo-p-dioxins and dibenzofurans (dioxins) are classed as persistent organic pollutants and have adverse effects on multiple functions within the body." | 1.46 | Protective effects of levamisole, acetylsalicylic acid, and α-tocopherol against dioxin toxicity measured as the expression of AhR and COX-2 in a chicken embryo model. ( Całkosiński, I; Dobrzyński, M; Gamian, A; Gostomska-Pampuch, K; Kowalczyk, A; Kuropka, P; Ostrowska, A; Ziółkowski, P; Łukaszewicz, E, 2017) |
| "Amitriptyline was also used in combination with aspirin and dexamethasone to inspect any synergistic effects." | 1.43 | Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats. ( Bhatt, S; Goswami, S; Raval, J; Shukla, P, 2016) |
| "Nimodipine and aspirin were set as positive control separately." | 1.43 | Sodium Sulfide, a Hydrogen Sulfide-Releasing Molecule, Attenuates Acute Cerebral Ischemia in Rats. ( Chen, B; Cheng, MH; Fan, BS; Shi, HQ; Tian, JS; Yu, JG; Zhang, Y, 2016) |
| "Acute lung injury is a life-threatening condition caused by disruption of the alveolar-capillary barrier leading to edema, influx of inflammatory leukocytes, and impaired gas exchange." | 1.43 | Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia. ( Abdulnour, RE; Colas, RA; Colby, JK; Cui, Y; Dalli, J; El-Chemaly, S; Hellmann, J; Levy, BD; Petasis, NA; Serhan, CN; Sham, HP; Spite, M; Winkler, JW; Wong, B, 2016) |
| "Dual treatment with aspirin (5 mg kg(-1) ) and clopidogel (0." | 1.43 | A rabbit model of cerebral microembolic signals for translational research: preclinical validation for aspirin and clopidogrel. ( Chu, L; Desai, K; Gutstein, DE; Kurowski, S; Seiffert, D; Wang, X; Wu, W; Zhou, X, 2016) |
| "The rate of cerebral aneurysm rupture was similar in male mice receiving aspirin and 15-hydroxyprostaglandin dehydrogenase inhibitor compared with females receiving aspirin and 15-hydroxyprostaglandin dehydrogenase agonist, signaling a reversal of the sex-differential response to aspirin." | 1.43 | Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice. ( Brown, RD; Chalouhi, N; Correa, T; Hasan, DM; Jabbour, PM; Starke, RM; Torner, JC; Zanaty, M, 2016) |
| "Aspirin-PC was more potent (vs." | 1.43 | Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer. ( Bottsford-Miller, JN; Dial, EJ; Dorniak, PL; Fang, D; Filant, J; Haemmerle, M; Hansen, JM; Hatakeyama, H; Hu, W; Huang, Y; Lichtenberger, LM; Lyons, Y; Pradeep, S; Previs, RA; Shen, F; Sood, AK; Taylor, M; Wagner, MJ, 2016) |
| "The effective targeting of metastasis-related-pathways in cancer holds promise for a new generation of therapeutics." | 1.43 | A novel co-drug of aspirin and ursolic acid interrupts adhesion, invasion and migration of cancer cells to vascular endothelium via regulating EMT and EGFR-mediated signaling pathways: multiple targets for cancer metastasis prevention and treatment. ( Chen, H; Jia, L; Li, T; Liu, Y; Shao, J; Tang, Q; Yang, X; Zheng, G, 2016) |
| "Aspirin is a very common anti-inflammatory medication to relieve aches and pains." | 1.43 | Aspirin-Based Carbon Dots, a Good Biocompatibility of Material Applied for Bioimaging and Anti-Inflammation. ( Bu, W; Chang, B; Gu, Z; Li, C; Lin, C; Shen, Y; Sun, H; Xu, X; Yang, B; Zhang, K; Zhao, L; Zheng, C, 2016) |
| "The endometriomas were measured on days 1, 7, 14 and 21." | 1.42 | Development of a subcutaneous endometriosis rat model. ( Almeida, PR; Dias, BH; Guimarães, SB; Medeiros, Fd; Pereira, FE; Vasconcelos, PR, 2015) |
| "There are many available drugs for treating gastric ulcer, but they have various side effects." | 1.42 | The postulated mechanism of the protective effect of ginger on the aspirin induced gastric ulcer: Histological and immunohistochemical studies. ( Salah Khalil, M, 2015) |
| "Kaempferol was shown to attenuate the expansion of inflammatory lesions seen in ethanol (EtOH)/HCl- and aspirin-induced gastritis, LPS/caerulein (CA) triggered pancreatitis, and acetic acid-induced writhing." | 1.42 | Kaempferol, a dietary flavonoid, ameliorates acute inflammatory and nociceptive symptoms in gastritis, pancreatitis, and abdominal pain. ( Baek, KS; Cho, JY; Ha, VT; Kim, E; Kim, HG; Kim, JH; Kim, SH; Lee, MN; Park, JG; Sung, GH; Sung, NY; Yang, S; Yang, WS; Yi, YS, 2015) |
| "Simvastatin has important immune-modulatory and anti-inflammatory effects independent of lipid lowering effects." | 1.40 | Effect of simvastatin on inflammatory cytokines balance in air pouch granuloma model. ( Al-Gayyar, MM; El-Gayar, AM; Hassan, HM; Ibrahim, TM, 2014) |
| "Stroke is the major cause of death and decrease in the activities of daily living." | 1.40 | Neurovascular protection of cilostazol in stroke-prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation. ( Abe, K; Deguchi, K; Ikeda, Y; Kono, S; Kurata, T; Liu, N; Liu, W; Omote, Y; Yamashita, T, 2014) |
| " Taken together, these findings identify a previously unrecognized role of TERT in improving the immunomodulatory capacity of BMMSCs, suggesting that aspirin treatment is a practical approach to significantly reduce cell dosage in BMMSC-based immunotherapies." | 1.40 | Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression. ( Akiyama, K; Chen, C; Li, B; Shi, S; Xu, X; Yamaza, T; You, YO; Zhao, Y, 2014) |
| "Treatment with enalapril and ASS led to significant downregulation of known target genes Vegf and Rela at RNA level." | 1.40 | Enalapril and ASS inhibit tumor growth in a transgenic mouse model of islet cell tumors. ( Baier, A; Bartsch, DK; Fendrich, V; Holler, JP; Lopez, CL; Manoharan, J; Maschuw, K; Ramaswamy, A; Waldmann, J; Wichmann, S, 2014) |
| "MOR8457 also reduced liver fibrosis in mice placed on DDC-supplemented diets." | 1.40 | Extrahepatic platelet-derived growth factor-β, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice. ( Arch, RH; Chung, J; Ikenaga, N; Kim, YO; Liu, SB; Miyamoto, M; Ogawa, S; Peng, ZW; Popov, Y; Schuppan, D; Sverdlov, DY; Yoshida, S, 2014) |
| " The serial dosages were used in vivo: the low dosage, the medium dosage and the high dosage." | 1.39 | Anti-inflammatory effects of essential oil in Echinacea purpurea L. ( Hu, F; Jiang, L; Tai, Y; Xie, Z; Yang, X; Yu, D; Yuan, Y, 2013) |
| "Cystitis was induced in female rats by a single CYP injection." | 1.39 | Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder. ( Augé, C; Chene, G; Coelho, AM; Corman, B; Desoubzdanne, D; Dubourdeau, M; Lluel, P; Palea, S; Vergnolle, N, 2013) |
| "Bladder cancer is a common urological malignancy with high recurrence rate, which may be reduced by chemoprevention." | 1.39 | Oral chemoprevention with acetyl salicylic Acid, vitamin D and calcium reduces the risk of tobacco carcinogen-induced bladder tumors in mice. ( Burcharth, J; Pommergaard, HC; Raskov, H; Rosenberg, J, 2013) |
| "Pancreatic cancer is a deadly disease killing 37,000 Americans each year." | 1.39 | A novel combinatorial nanotechnology-based oral chemopreventive regimen demonstrates significant suppression of pancreatic cancer neoplastic lesions. ( Grandhi, BK; Prabhu, S; Thakkar, A; Wang, J, 2013) |
| "Stroke is the second leading cause of death." | 1.39 | Neuroprotective effect of a new synthetic aspirin-decursinol adduct in experimental animal models of ischemic stroke. ( Ahn, JH; Cho, JH; Choi, JH; Her, S; Hwang, IK; Hyun, BH; Jun, JG; Kim, CK; Kim, IH; Kim, JS; Kim, YM; Kwon, SH; Kwon, YG; Lee, CH; Lee, JC; Lee, YL; Park, JH; Shin, BN; Suh, HW; Won, MH; Yan, BC; Yoo, KY, 2013) |
| "Rats treated with aspirin showed intestinal barrier dysfunction; high contents of the specific antigen were absorbed into the lamina propria." | 1.39 | Oral antigens induce rheumatoid arthritis-like inflammation in a rat model. ( Chen, X; Hu, D; Huang, Z; Liu, X; Liu, Z; Su, H; Wu, D; Yang, PC; Zhang, H, 2013) |
| "Lung injury was assessed by wet/dry ratio, myeloperoxidase (MPO) activity, and bronchoalveolar lavage (BAL) neutrophil counts." | 1.38 | Protective role of cyclooxygenase (COX)-2 in experimental lung injury: evidence of a lipoxin A4-mediated effect. ( Bouchier-Hayes, D; Condron, C; Cunningham, AJ; Gang, C; Scully, M, 2012) |
| "Aspirin is an anti-inflammatory drug demonstrated to possess a tremendous anticancer potential." | 1.38 | Gender-specific antitumor action of aspirin in a murine model of a T-cell lymphoma bearing host. ( Bharti, AC; Kumar, A; Singh, SM; Vishvakarma, NK, 2012) |
| "Gastric ulcers were induced in mice by oral administration of hydrochloride (HCl)/ethanol or acidified aspirin." | 1.38 | Protective effects of astaxanthin from Paracoccus carotinifaciens on murine gastric ulcer models. ( Hara, H; Ishibashi, T; Murata, K; Oyagi, A; Shimazawa, M; Takahira, D; Tsuruma, K, 2012) |
| "Infective endocarditis is a typical biofilm-associated infectious disease frequently caused by commensal streptococci, but the contribution of host factors in biofilm formation is unclear." | 1.38 | Platelets enhance biofilm formation and resistance of endocarditis-inducing streptococci on the injured heart valve. ( Cheng, HW; Chia, JS; Hsu, RB; Jung, CJ; Lin, CS; Shun, CT; Yeh, CY, 2012) |
| "Pre-treatment with arbutin or omeprazole protected the gastric mucosa as seen by reduction in ulcer area and mucosal content, reduced or absence of edema, inflammation and leucocytes infiltration on both models." | 1.38 | Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of arbutin. ( Abdelwahab, SI; Abdulla, MA; Ali, HM; Hadi, AH; Salga, MS; Taha, MM, 2012) |
| " We examined the possibility that concurrent blockade of free radicals and prostaglandin E(2) (PGE(2))-mediated inflammation might constitute a safe and effective therapeutic approach to ALS." | 1.38 | Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. ( Cho, W; Gwag, BJ; Im, DS; Lee, JH; Lee, JK; Lee, YA; Lee, YB; Shin, JH; Springer, JE; Yun, BS, 2012) |
| "Gastric ulcer was induced by administering alcohol (or) acetylsalicylic acid (or) hypothermic restraint stress to rats pretreated with HAEPD (200 mg/kgbwt for 30 day)." | 1.38 | Antiulcerogenic activity of hydroalcoholic fruit extract of Pithecellobium dulce in different experimental ulcer models in rats. ( Geetha, A; Megala, J, 2012) |
| "Aspirin treatment of hPLTs in vitro abolished hPLT accumulation in the lung and protected mice from lung injury." | 1.38 | Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury. ( Chi, X; Gelderman, MP; Vostal, JG; Zhi, L, 2012) |
| "Focal cerebral ischemia was induced by MCA occlusion for 2 hours followed by reperfusion for 22 hours." | 1.37 | Protective effect of irbesartan, an angiotensin II receptor antagonist, alone and in combination with aspirin on middle cerebral artery occlusion model of focal cerebral ischemia in rats. ( Ahmad, SJ; Akhtar, M; Islam, F; Khanam, R; Pillai, KK; Pratap, R, 2011) |
| "Left ventricular thrombus (LVT) and rupture are important mechanical complications following myocardial infarction (MI) and are believed to be due to unrelated mechanisms." | 1.37 | Role of intramural platelet thrombus in the pathogenesis of wall rupture and intra-ventricular thrombosis following acute myocardial infarction. ( Dart, AM; Du, XJ; Gao, XM; Head, GA; Kiriazis, H; Liu, Y; Lobo, A; Shan, L, 2011) |
| "Aspirin treatment also reduced right ventricular hypertrophy and pulmonary arteriole proliferation in ASA-treated PAH model." | 1.37 | Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5-hydroxytryptamine levels. ( He, B; Pu, J; Shen, J; Shen, L, 2011) |
| "Aspirin treatment led to the normalization of inflammation- and oxidative stress-related mRNA levels in treated MPS IIIA mouse brains." | 1.37 | Neuroinflammatory and oxidative stress phenomena in MPS IIIA mouse model: the positive effect of long-term aspirin treatment. ( Arfi, A; Bonnefont-Rousselot, D; Gandolphe, C; Richard, M; Scherman, D; Thérond, P, 2011) |
| "Choline is a α7 nicotinic receptor agonist that has antinociceptive effects in a variety of pain models." | 1.37 | Pharmacological action of choline and aspirin coadministration on acute inflammatory pain. ( Hai, W; Hai-Tao, Y; Jin-Da, W; Ru-Huan, W; Xiang-Di, Z; Yong-Ping, S, 2011) |
| " Collagen and U46619 caused in vivo thrombus formation with the former, but not latter, sensitive to oral dosing with aspirin." | 1.37 | Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse. ( Armstrong, PC; Emerson, M; Kirkby, NS; Mitchell, JA; Warner, TD; Zain, ZN, 2011) |
| "Chronic myocardial ischemia was induced using a minimally invasive model in 16 landrace pigs." | 1.37 | Gene therapy with iNOS enhances regional contractility and reduces delayed contrast enhancement in a model of postischemic congestive heart failure. ( Abegunewardene, N; Gori, T; Horstick, G; Kreitner, KF; Lehr, HA; Münzel, T; Schmidt, KH; Schreiber, LM; Vosseler, M, 2011) |
| "To discover analgesics for treating chronic pain 17 novel Schiff's bases, N,N'-(Z-allylidene-1,3-diyl)bisamino acid methyl esters were prepared from 1,1,3,3,-tetramethoxypropane and amino acid methyl esters." | 1.36 | A class of novel Schiff's bases: Synthesis, therapeutic action for chronic pain, anti-inflammation and 3D QSAR analysis. ( Li, C; Peng, L; Peng, S; Wu, J; Wu, Y; Zhao, M; Zheng, M; Zhou, Y, 2010) |
| "Furthermore, development of invasive pancreatic cancer in LsL-Kras(G12D); LsL-Trp53(R172H); Pdx1-Cre transgenic mice was partially inhibited by enalapril and aspirin." | 1.36 | The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer. ( Bartsch, DK; Buchholz, M; Chen, NM; Feldmann, G; Fendrich, V; Maitra, A; Neef, M; Slater, EP; Waldmann, J, 2010) |
| "Naproxen, which has an excellent cardiovascular profile, or epidermal growth factor receptor inhibitors may be effective in an adjuvant setting." | 1.36 | Screening agents for preventive efficacy in a bladder cancer model: study design, end points, and gefitinib and naproxen efficacy. ( Grubbs, CJ; Juliana, MM; Lubet, RA; Steele, VE, 2010) |
| "With aspirin, however, it has long been believed that it is difficult to induce any damage in the intestinal mucosa of laboratory animals." | 1.36 | New method of inducing intestinal lesions in rats by intraduodenal administration of aspirin. ( Amagase, K; Nakagawa, K; Nakamura, M; Nonoyama, K; Okabe, S; Takeuchi, K, 2010) |
| "VEGF may play a role in ovarian cancer progression in the hen and the proliferation of ascites cells can be decreased by targeting the COX-1 but not COX-2 pathway." | 1.35 | VEGF expression and the effect of NSAIDs on ascites cell proliferation in the hen model of ovarian cancer. ( Giles, JR; Johnson, PA; Urick, ME, 2008) |
| "Aspirin treatment also restored endothelial function and beta(2)-adrenoceptor activity." | 1.35 | Antioxidative action of aspirin on endothelial function in hypercholesterolaemic rats. ( Fahim, M; Shahid, M; Sharma, KK; Tauseef, M, 2008) |
| " The authors--in view of the increased neuroinflammatory reaction frequently observed during normal brain ageing--suggest the long-term use of "fatty aspirin", an association of DHA and/or NPD1 and aspirin (or nitroaspirin), to postpone, or prevent, the structural neurodegeneration of the brain." | 1.35 | Fatty aspirin: a new perspective in the prevention of dementia of Alzheimer's type? ( Bria, P; Di Gioia, A; Pomponi, M; Pomponi, MF, 2008) |
| "Aspirin treatment decreased liver PGE(2) in treated hens as compared to control hens." | 1.35 | Dietary aspirin decreases the stage of ovarian cancer in the hen. ( Giles, JR; Johnson, PA; Urick, ME, 2009) |
| "Indomethacin is used to close the patent ductus arteriosus in premature infants and for tocolysis of preterm labor." | 1.35 | Delayed neonatal closure of the ductus arteriosus following early in utero exposure to indomethacin in the rat. ( Imamura, S; Ito, K; Momma, K; Nakanishi, T; Sugiyama, K; Sun, F; Toyoshima, K, 2009) |
| "Curcumin is a yellow-colored plant polyphenol with a long history of medicinal use in ayurvedic, Chinese and Japanese medicine." | 1.35 | Curcumin potentiates the anti-inflammatory activity of cyclooxygenase inhibitors in the cotton pellet granuloma pouch model. ( Chopra, K; Dhir, A; Kuhad, A; Nandal, S; Sharma, S, 2009) |
| " The present study investigated the importance of endogenous prostaglandin production and nitric oxide (NO) in the renal haemodynamic and excretory responses to ischaemia-reperfusion both normally and in the hypertensive state by chronic administration of cyclo-oxygenase (COX) inhibitors." | 1.35 | Renal functional responses to ischaemia-reperfusion injury in normotensive and hypertensive rats following non-selective and selective cyclo-oxygenase inhibition with nitric oxide donation. ( Johns, EJ; Knight, S, 2008) |
| " Increasing evidence suggests that an inflammatory reaction accompanies the pathological processes caused by Cyclooxygenase (COX) seen in many neurodegenerative disorders, including PD and according to the recent researches chronic use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) decreases the risk of PD in human." | 1.34 | Effects of aspirin and celecoxib on rigidity in a rat model of Parkinson's disease. ( Abid, KM; Ardestani, MS; Hemmati, A; Mehrab, H; Moghaddam, HF; Nazari, Z, 2007) |
| "Atherosclerosis is an inflammatory response of the arterial wall to 'injury', which is prominently driven by inflammatory factors." | 1.34 | Effect of clopidogrel on the inflammatory progression of early atherosclerosis in rabbits model. ( Li, M; Ren, H; Zhang, Y; Zhu, X, 2007) |
| " The antinociceptive efficacies were evaluated using several dose-response curves and time courses." | 1.34 | Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents. ( Déciga-Campos, M; González-Trujano, ME; Guevara-Fefer, P; López-Muñoz, FJ; Martínez, AL; Moreno, J; Peña, EI, 2007) |
| " Low-dose razaxaban was useful in combination with sub-optimal doses of aspirin and/or clopidogrel for the prevention of occlusive arterial thrombosis without excessive bleeding." | 1.34 | Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits. ( Crain, EJ; Knabb, RM; Lam, PY; Quan, ML; Watson, CA; Wexler, RR; Wong, PC, 2007) |
| "When ticlopidine was administered 1h after EtOH, it significantly (p<0." | 1.34 | Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat. ( De Luca, V; Guidobono, F; Lattuada, N; Netti, C; Pagani, F; Sibilia, V; Soglian, A, 2007) |
| "Naloxone pretreatment had no effect on the antinociceptive effects of intradermal diclofenac, ketorolac, lysine acetyl salicylate, and sodium salicylate." | 1.34 | The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test. ( Deveci, MS; Dogrul, A; Gul, H; Gülmez, SE; Ossipov, MH; Porreca, F; Tulunay, FC, 2007) |
| "Nitroglycerin can increase gastric blood flow and slow gastric emptying." | 1.34 | Intragastric nitroglycerin at a vasodilatory dose attenuates acidified aspirin-induced gastric mucosal injury. ( Chan, CC; Leung, FW, 2007) |
| " At the antithrombotic dosage they were free from prohemorrhagic side effect at variance with acetylsalicylic acid used as reference drug." | 1.34 | Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. ( Ballabeni, V; Barocelli, E; Bertoni, S; Bruni, R; Impicciatore, M; Tognolini, M, 2007) |
| " Platelet aggregation induced by ADP and dosing of prostanoid products 6-keto-PGF1alpha, TXB2, PGE2 and LTB4 were also performed." | 1.34 | Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension. ( Aguejouf, O; Belon, P; Desplat, V; Doutremepuich, C; Eizayaga, FX, 2007) |
| "However, indomethacin-induced nasal blockage was not provoked in non-sensitized animals." | 1.34 | Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis. ( Fujii, M; Han, HY; Kohno, S; Mizutani, N; Nabe, T; Takenaka, H; Terada, T, 2007) |
| "Treatment with aspirin (200 mg/kg, p." | 1.33 | Influence of protein malnutrition on induction and treatment of inflammation in mice. ( Bassiouny, K; Hamed, MR; Hassanein, NM; Talaat, RM, 2006) |
| "When choline (2 mg/kg) was coadministered with aspirin (9." | 1.33 | Antinociceptive effects of choline against acute and inflammatory pain. ( Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y, 2005) |
| "Rofecoxib in lower doses had the same effect on adenomas (p < 0." | 1.33 | Cyclooxygenase-2 inhibition in colon experimental carcinogenesis. ( Amengual Antich, I; Gamundí Gamundí, A; Ibarra de la Rosa, J; Noguera Aguilar, JF; Plaza Martínez, A; Pujol Tugores, JJ; Tortajada Collado, C, 2005) |
| "Aspirin was given starting 3 days before the intervention and administered for an additional 4 weeks." | 1.33 | Prevention of carotid artery restenosis after sirolimus-coated stent implantation in pigs. ( Claussen, CD; Dinkelborg, LM; Duda, SH; Laule, M; Muschick, P; Reddig, F; Tepe, G; Tielemans, H; Wehrmann, M, 2006) |
| "Thus, NO-ASA profoundly prevented pancreatic cancer and modulated multiple molecular targets in this model system; conventional ASA had no such effects." | 1.33 | Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model. ( Gao, J; Iatropoulos, MJ; Kashfi, K; Kopelovich, L; Ouyang, N; Rigas, B; Tsioulias, GJ; Williams, JL, 2006) |
| "Aspirin was found to be a potent inhibitor of the UPS in some tumour studies; however, its effect on AS remains to be demonstrated in vivo." | 1.33 | Inhibition of the ubiquitin-proteasome system: a new avenue for atherosclerosis. ( Huang, W; Li, Y; Pan, H; Tan, C; Tan, X, 2006) |
| "ASA, captopril or losartan were given at a concentration of 40 mg/kg/day in drinking water." | 1.32 | Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. ( Browne, AE; Chatterjee, K; Grossman, W; Karliner, JS; Lee, RJ; Parmley, WW; Sievers, RE; Zhu, BQ, 2003) |
| "Aspirin pretreatment increased the tongue-bleeding time, whereas the addition of CRL42796 or enoxaparin did not prolong bleeding time to a further degree." | 1.32 | Glycoprotein IIb/IIIa receptor antagonist (2S)-2-[(2-Naphthyl-sulfonyl)amino]-3-[[2-([4-(4-piperidinyl)-2-[2-(4-piperidinyl)ethyl] butanoyl]amino)acetyl]amino]propanoic acid dihydrochloride (CRL42796), in combination with aspirin and/or enoxaparin, preven ( Driscoll, EM; Giboulot, TA; Hong, TT; Lucchesi, BR; Sherigill, A; White, AJ, 2003) |
| "Nitroaspirin has shown a number of significant advantages over the presently available antiplatelet agents; however, only clinical studies will say whether nitroaspirin represents a step forward in antithrombotic treatment." | 1.32 | NCX4016: a novel antithrombotic agent. ( Gresele, P; Mezzasoma, AM; Momi, S, 2003) |
| "Bradykinin is a potent endothelium-dependent vasodilator in the coronary vascular bed." | 1.32 | Involvement of nitric oxide and prostaglandin pathways in the cardioprotective actions of bradykinin in rats with experimental myocardial infarction. ( Akula, A; Veeravalli, KK, 2004) |
| " This study was designed to assess the antiepileptic activity of aspirin and to investigate the potentiation of its activity in combination with a subconvulsive dose of lamotrigine." | 1.32 | Evaluation of antiepileptic activity of aspirin in combination with newer antiepileptic lamotrigine in mice. ( Anuradha, K; Pandhi, P; Tandon, M, 2003) |
| "PHA-798 reduced thrombus formation on the thrombogenic surface in a dose-dependent manner (56+/-1." | 1.32 | Administration of a small molecule tissue factor/factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: effects on thrombus formation and bleeding time. ( Blom, JD; Case, BL; LaChance, RM; Nicholson, NS; Panzer-Knodle, SG; Parlow, JJ; Salyers, AK; South, MS; Suleymanov, OD; Szalony, JA; Wood, RS, 2003) |
| "However, systemic study of thrombus formation in vein grafts is still lacking, and few effective techniques are available to prevent this event." | 1.32 | Thrombosis and neointima formation in vein grafts are inhibited by locally applied aspirin through endothelial protection. ( Hu, Y; Mayr, U; Thompson, WD; Torsney, E; Xu, Q; Zou, Y, 2004) |
| "Autoimmune diseases are a group of illnesses in which autoantibodies are produced against various organs, presenting with a variety of clinical symptoms." | 1.32 | Maternal autoimmune diseases and immunologically induced embryonic and fetoplacental damage. ( Chen, L; Miller, RK; Ornoy, A; Silver, RM, 2004) |
| "Myocardial infarction (MI) and congestive heart failure (CHF) were induced in rats by ligating the left coronary artery." | 1.32 | Inhibition of COX pathway in experimental myocardial infarction. ( Giaid, A; Hu, F; Huynh, T; Robinson, R; Rodger, IW; Saito, T, 2004) |
| "A novel model to induce occlusive thrombus formation was developed in mice in vivo." | 1.32 | A novel model of occlusive thrombus formation in mice. ( Cheng, XW; Iguchi, A; Kanda, S; Koike, T; Kuzuya, M; Maeda, K; Nakamura, K; Sasaki, T; Sato, K; Tamaya-Mori, N, 2004) |
| "Main parameter was thrombus weight." | 1.32 | Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model. ( Bégaud, B; Boisseau, M; Moore, N; Umar, A; Upur, H; Yusup, A, 2004) |
| "Both morphine and lidocaine were active topically in the tail formalin assay, although their time-course of action appeared to be shorter than that of the formalin." | 1.32 | Evaluation of the tail formalin test in mice as a new model to assess local analgesic effects. ( Cristea, M; Kolesnikov, Y; Oksman, G; Torosjan, A; Wilson, R, 2004) |
| "Endothelial dysfunction, defined as a deficit in the bioavailability of nitric oxide (NO), occurs as sequelae of many vascular diseases; however, the utility of supplementing NO to obviate the extent of disease is understudied." | 1.31 | Nitric oxide-releasing aspirin decreases vascular injury by reducing inflammation and promoting apoptosis. ( Rudic, RD; Sessa, WC; Yu, J, 2002) |
| "Both everolimus treatment groups significantly reduced in-stent neointimal growth (46% reduction and 42% reduction in intimal thickness in groups 1 and 2, respectively)." | 1.31 | Oral everolimus inhibits in-stent neointimal growth. ( Acampado, E; Farb, A; John, M; Kolodgie, FD; Prescott, MF; Virmani, R, 2002) |
| " Combination therapy may produce synergic effects with better tumor inhibition as well as lower dosage or side affects." | 1.31 | [Effects of combination of octreotide and aspirin on proliferation of human hepatocellular carcinoma]. ( Tang, CW; Tang, LP; Wang, CH, 2002) |
| "Pre-treatment with aspirin lessened the number of CFRs but did not reduce platelet accumulation in LAD myocardium (483+/-148%)." | 1.31 | Dynamic intracoronary thrombosis does not cause significant downstream platelet embolization. ( Barrabés, JA; Garcia-Dorado, D; Garcia-Lafuente, A; Puigfel, Y; Solares, J; Soler-Soler, J; Soriano, B; Trobo, L, 2000) |
| "The effects of classical and new anti-migraine drugs such as acetylsalicylic acid (ASA), sumatriptan and the new high efficacy 5-HT1B/1D agonist donitriptan (4-[4-[2-(2-aminoethyl)-1H-indol-5-yloxyl]acetyl]piperazinyl-1-yl]benzonitrile) were evaluated in comparison with the established model of neurogenic inflammation in the meninges." | 1.31 | An in vivo rat model to study calcitonin gene related peptide release following activation of the trigeminal vascular system. ( Diener, HC; Guehring, H; Katsarava, Z; Liedert, B; Limmroth, V; Michel, MC; Schmitz, K, 2001) |
| "Ticlopidine treatment resulted in increased platelet endostatin content and release." | 1.31 | Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. ( Buret, A; Cirino, G; Elliott, SN; Ignarro, LJ; Ma, L; Wallace, JL, 2001) |
| "In celecoxib-treated animals, vasodilation in response to arachidonic acid was reduced significantly compared with controls." | 1.31 | Effects of selective cyclooxygenase-2 inhibition on vascular responses and thrombosis in canine coronary arteries. ( Barrett, TD; Crofford, LJ; Driscoll, EM; Hennan, JK; Huang, J; Lucchesi, BR; Park, AM; Willens, DE, 2001) |
| "However, only r-hirudin inhibited thrombus formation at a therapeutical prolongation of aPTT, while heparin required supratherapeutical amounts to achieve the same inhibition." | 1.30 | A technique to investigate microvascular mural thrombus formation in arteries and veins: II. Effects of aspirin, heparin, r-hirudin, and G-4120. ( Hoylaerts, MF; Nyström, A; Stassen, JM; Stockmans, F; Vermylen, J, 1997) |
| "Acetaminophen has no effect on the rate of tooth movement in rabbits undergoing orthodontic treatment." | 1.30 | The effect of acetaminophen on tooth movement in rabbits. ( Acs, G; Cisneros, GJ; Roche, JJ, 1997) |
| " A statistically significant increase in the threshold for 2 kHz was found 1 to 72 hr after dosing but not for 4, 8 and 10 kHz." | 1.30 | Frequency selectivity on aspirin-induced hearing loss in rats with auditory stimulus-induced conditioned suppression. ( Kurata, K; Nishida, N; Sato, S; Suzuki, T; Tokuriki, M; Tsukuda, R, 1997) |
| "A controlled hemorrhagic shock (blood withdrawal of 40 mL/kg) was followed by resuscitation with either a combination of lactated Ringer's solution (75 mL/kg) and modified gelatin (15 mL/kg)(lactR/Gel) or 10% DCLHb (5 mL/kg)." | 1.30 | Low-volume resuscitation with a hemoglobin-based oxygen carrier after hemorrhage improves gut microvascular oxygenation in swine. ( Burhop, K; Ince, C; Sinaasappel, M; Trouwborst, A; van Iterson, M, 1998) |
| "Oral aspirin also inhibited thrombus formation in arterioles but not in venules, although the antithrombotic effects were delayed and prolonged." | 1.30 | The differential effects of aspirin on platelets, leucocytes and vascular endothelium in an in vivo model of thrombus formation. ( Giddings, JC; Hashimoto, M; Nagamatsu, Y; Tsujioka, Y; Yamamoto, J, 1999) |
| " BC2 extended aPTT to a maximum of 60 to 80 seconds at 100 to 1000 nmol/L in vitro (rat and human plasma, respectively) and ex vivo (rat) after dosing of rats up to 6 mg/kg in vivo." | 1.30 | Antithrombotic efficacy of a novel murine antihuman factor IX antibody in rats. ( Baker, A; Blackburn, MN; Bugelski, P; Church, WR; Feuerstein, GZ; Koster, P; Nichols, AJ; Patel, A; Toomey, JR; Valocik, R, 1999) |
| "74), and the areas under the time-serum salicylate concentration curve over 6 hours were 171,000 +/- 24,000 mg." | 1.29 | Effect of multiple-dose activated charcoal on the clearance of high-dose intravenous aspirin in a porcine model. ( Eppler, J; Fraga, C; Giesbrecht, E; Ito, S; Johnson, D; Rais, A; Verjee, Z; Wiggins, T, 1995) |
| "Aspirin (30 mg) was given orally before experiment." | 1.29 | A new animal model of coronary thrombosis and effects of antithrombotic agents. ( Chen, Z; Fan, Y; Wang, P; Zhang, W, 1995) |
| "Treatment with aspirin for 2 or 7 days had no effect on the constrictive responses at the injured site 1 month after injury or on those at the noninjured site at all times examined." | 1.29 | Inhibitory effects of aspirin on coronary hyperreactivity to autacoids after arterial balloon injury in miniature pigs. ( Ibayashi, S; Kuga, T; Ohara, Y; Shimokawa, H; Takeshita, A; Tomoike, H, 1995) |
| "Aspirin treatment is recognized as an advantageous adjunct to thrombolytic agents in myocardial infarct patients." | 1.29 | Intravenous aspirin causes a paradoxical attenuation of cerebrovascular thrombolysis. ( Bednar, MM; Bennett, WF; Errett, CJ; Gross, CE; Thibodeaux, H; Thomas, GR, 1995) |
| "To examine whether the dosage of a platelet-suppressive agent at which an antithrombotic effect is adequate and bleeding tendency is not increased can be found, the antithrombotic effects, antiplatelet effects and bleeding times of ticlopidine and aspirin were investigated in the rat experimental thrombus formation model." | 1.29 | Correlation between bleeding time and antithrombotic effect of platelet-suppressive agents in rat experimental model. ( Kakishita, E; Oura, Y; Suehiro, A; Ueda, M, 1994) |
| "Most of cerebral infarctions were observed in the hemisphere, ipsilateral to the irradiated carotid artery." | 1.29 | Effect of Y-20811, a thromboxane synthetase inhibitor, on photochemically induced cerebral embolism in rabbits. ( Fujimura, M; Mikashima, H, 1993) |
| "We developed a rat model of hemorrhagic shock based on achieving a fixed BD of 13 +/- 1 mmol/L before resuscitation." | 1.29 | Use of base deficit to compare resuscitation with lactated Ringer's solution, Haemaccel, whole blood, and diaspirin cross-linked hemoglobin following hemorrhage in rats. ( Hamilton, IN; Malcolm, DS; Schultz, SC, 1993) |
| "This produced an occlusive thrombus in all vehicle-treated ferrets within 41 +/- 3 min with an average weight of 8 +/- 1 mg (n = 7)." | 1.29 | A ferret model of electrical-induction of arterial thrombosis that is sensitive to aspirin. ( Durham, SK; Megill, JR; Schumacher, WA; Steinbacher, TE, 1996) |
| "However, their effects on thrombus formation have rarely been evaluated in experimental animals in vivo." | 1.29 | In vivo evaluation of antiplatelet agents in gerbil model of carotid artery thrombosis. ( Iwamoto, Y; Naritomi, H; Nishimura, H; Sugita, M; Tachibana, H, 1996) |
| " Dose-response analyses employing the fever model demonstrated that potency of aspirin to reduce fever was increased 5 to 10-fold when the aspirin was intragastrically administered in the lipid-associated state." | 1.29 | Zwitterionic phospholipids enhance aspirin's therapeutic activity, as demonstrated in rodent model systems. ( Dial, EJ; Illich, PA; Lichtenberger, LM; Romero, JJ; Ulloa, C; Vanous, AL; Walters, ET, 1996) |
| "Aspirin (50 mg." | 1.29 | [A rat middle cerebral artery thrombosis model for evaluation of thrombolytic and antithrombotic agents]. ( Liu, XG; Xu, LN, 1995) |
| "Thrombus was formed within seconds after laser injury and grew rapidly." | 1.29 | Antithrombotic effects of aspirin and LMWH in a laser-induced model of arterials and venous thrombosis. ( Aguejouf, O; Doutremepuich, C; Doutremepuich, F; Imbault, P, 1996) |
| "Inogatran-treated pigs showed a dose-dependent antithrombotic effect, and the average patency rates were 34 +/- 39, 54 +/- 37 and 80 +/- 32%, in groups 6, 7 and 8, respectively." | 1.29 | Antithrombotic activity of inogatran, a new low-molecular-weight inhibitor of thrombin, in a closed-chest porcine model of coronary artery thrombosis. ( Grip, L; Mattsson, C; Rydén, L; Sjöquist, PO; Uriuda, Y; Wang, QD, 1996) |
| "injection inhibited thrombus formation in small mesenteric vessels for more than 12 hours but less than 24 hours." | 1.28 | [Evaluation of the antithrombotic effects of pentoxifylline, acetylsalicylic acid and low molecular weight heparin in the laser model of thrombosis]. ( Bielawiec, M; Breddin, HK; Krupiński, K; Płonowski, A, 1992) |
| "Pretreatment with aspirin and Y-20811, a thromboxane synthetase inhibitor, significantly prolonged the time required for occlusion in the guinea-pigs, while these drugs were ineffective in the rats." | 1.28 | Arterial thrombosis model with photochemical reaction in guinea-pig and its property. ( Hirata, Y; Nakashima, M; Takiguchi, Y; Wada, K, 1992) |
| "The composition of the thrombus is analyzed by double isotope labeling of platelets and fibrinogen." | 1.28 | [Arterioarterial shunt coated with collagen. A model of acute arterial thrombosis for testing antithrombotic agents in rats]. ( Cazenave, JP; Freund, M; Mantz, F, 1991) |
| "Picotamide did not inhibit the formation of TxB2 in serum at any of the doses tested (100 to 750 mg/kg i." | 1.28 | Picotamide protects mice from death in a pulmonary embolism model by a mechanism independent from thromboxane suppression. ( Alberti, P; Corona, C; Gresele, P; Nenci, GG, 1990) |
| "In the first model thrombosis is induced in the vena cava by a combination of venous stasis and hypercoagulability; these thrombi consist merely of red cells and fibrin with only a few platelets." | 1.28 | Comparison of two experimental thrombosis models in rats effects of four glycosaminoglycans. ( Bourgondiën, FG; Hobbelen, PM; Meuleman, DG; Vogel, GM, 1989) |
| "Like human patients with Reye's syndrome, these rats showed hyperammonemia, compromised fatty acid oxidation, and accumulation of branched chain amino acid oxidation metabolites." | 1.28 | Hepatic metabolic alterations in rats treated with low-dose endotoxin and aspirin: an animal model of Reye's syndrome. ( Corkey, BE; Douglas, SD; Kilpatrick, LE; Polin, RA, 1989) |
| "The effects of protein deficiency on the biosynthesis of metabolites of arachidonic acid by rat pleural polymorphonuclear leukocytes stimulated with calcium ionophore were investigated." | 1.27 | Effects of protein deficiency on the metabolism of arachidonic acid by rat pleural polymorphonuclear leukocytes. ( Powell, WS; Varma, DR; Yue, TL, 1983) |
| "Effects of influenza B infection, aspirin treatment and hyperammonemia on the level of free fatty acids, total lipids and triacylglycerols in serum and liver of an animal model of Reye's syndrome are reported here." | 1.27 | Free fatty acids in an animal model of Reye's syndrome. ( Deshmukh, DR; Deshmukh, GD; Radin, NS; Shope, TC, 1983) |
| " These occurred only in the groups given MNNG in combination with stress, aspirin, or sodium taurocholate, and did not occur in experimental groups given either MNNG, stress, aspirin, or sodium taurocholate alone, and did not occur in the control group." | 1.27 | Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate. ( Cohen, A; Geller, SA; Horowitz, I; Toth, LS; Werther, JL, 1984) |
| "Thrombosis was produced in the aorta by the combination of local partial obstruction and systemic administration of hypotonic saline with serotonin." | 1.27 | The effect of antithrombotics in a new model of arterial thrombosis. ( Hladovec, J, 1986) |
| "Aspirin is a possible cofactor with influenza B virus in Reye's syndrome." | 1.27 | Influenza B virus model of Reye's syndrome in mice: the effect of aspirin. ( Davis, LE; Green, CL; Wallace, JM, 1985) |
| "Trapidil was expected to be an effective antithrombotic agent." | 1.26 | Antithrombotic activity and the mechanism of action of trapidil (Rocornal). ( Kitamura, Y; Ohnishi, H; Shimada, S; Suzuki, Y; Yamaguchi, K, 1982) |
| "Aspirin treatment however may be a precipitating factor when associated with other abnormalities of platelet function." | 1.26 | Bleeding time in rats: a comparison of different experimental conditions. ( de Gaetano, G; Dejana, E; Villa, S, 1982) |
| "Recent studies of Reye syndrome (RS) patients have suggested aspirin treatment as a possible factor in the etiology of this often fatal childhood disorder." | 1.26 | Interactions of aspirin and other potential etiologic factors in an animal model of Reye syndrome. ( Deshmukh, DR; Maassab, HF; Mason, M, 1982) |
| "Aspirin administration, at a dosage producing plasma levels within the human therapeutic range, caused marked inhibition of production of both vascular prostacyclin (a vasodilator) and platelet thromboxane (a vasoconstrictor) in beagle puppies." | 1.26 | Retrolental fibroplasia: evidence for a role of the prostaglandin cascade in the pathogenesis of oxygen-induced retinopathy in the newborn beagle. ( Blake, DA; Flower, RW, 1981) |
| "In 67 dogs with a 60-80% coronary stenosis produced by an external constricting plastic ring, blood flow measured with an electromagnetic flowmeter showed cyclical flow reductions of varying magnitude and duration, and then an abrupt return to control flow." | 1.26 | Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation? ( Folts, JD; Gallagher, K; Rowe, GG, 1982) |
| "Pretreatment with cimetidine caused a significant reduction in gastric mucosal injury in stressed animals receiving gastric mucosal barrier breakers." | 1.26 | Cimetidine protects against stress-induced gastric injury augmented by mucosal barrier breakers. ( Levine, BA; Pruitt, BA; Sirinek, KR, 1979) |
| "Heparin reduced thrombus only when sufficient was given to reduce blood coagulation." | 1.26 | Effects of heparin, aspirin and dipyridamole on thrombus formation on venous catheters. ( Hecker, JF; Spanos, HG, 1979) |
| " In animals pretreated by anti-inflammatory drugs in toxic doses an earlier development of ulceration was observed by distention with acid." | 1.26 | Distention ulcer as a model for testing of drugs for ulcerogenic side effects. ( Szelenyi, I; Thiemer, K, 1978) |
| "Rats treated with indomethacin showed a marked decrease of proteinuria (tested by the 3% sulfosalicylic aicd method) and a clear ultrastructural picture of hyperplasia and hypertrophy of podocytes." | 1.26 | Indomethacin and lysine acetylsalicylate in rats with autologous nephrotoxic serum nephritis. Biochemical and morphological studies. ( Cioffi, A; Conte, F; Di Belgiojoso, GB; Donati, MB; Saruggia, M; Sessa, A, 1978) |
| "Aspirin pretreatment prevented the ocular response following the intravenous injection of 10 mug per kilogram of endotoxin, but had no effect following 100 mug per kilogram." | 1.26 | The effects of aspirin and indomethacin on the ocular response to circulating bacterial endotoxin in the rabbit. ( Howes, EL; McKay, DG, 1976) |
| "Osteoarthritis was induced in the rabbit by a single intra-articular injection of 0." | 1.26 | Activity of anti-inflammatory drugs on an experimental model of osteoarthritis. ( Cros, J; Guiraud, R; Marcelon, G, 1976) |
| "Unilateral cerebrovascular occlusion was produced in heparinized rats within seconds after injection of microgram quantities of sodium arachidonate into the internal carotid artery." | 1.26 | Arachidonate-induced cerebrovascular occlusion in the rat. The role of platelets and aspirin in stroke. ( Bass, NH; Furlow, TW, 1976) |
| "Aspirin, 56 mg/kg IP, was shown to be mildly, but significantly discriminable from saline in a group of 12 nonarthritic rats exposed to a 2-lever fixed ratio 10 drug discrimination protocol for 56 trials." | 1.26 | The discriminability of apsirin in arthritic and nonarthritic rats. ( Weissman, A, 1976) |
| "In anesthetized dogs soft tissue trauma resulting in hypovolemia was associated with pulmonary trapping of 51Cr tagged platelets." | 1.25 | Development and treatment of post-traumatic pulmonary platelet trapping. ( Peer, RM; Schwartz, SI, 1975) |
| "Factors determining thrombus formation on a foreign surface were studied with the use of plastic flow chambers introduced into extracorporeal shunts." | 1.25 | Extracorporeal model for study of factors affecting thrombus formation. ( Aledort, LM; Benis, AM; Koffsky, RM; Leonard, EF; Litwak, RS; Nossel, HL; Shiang, H; Stevenson, JF, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 145 (18.45) | 18.7374 |
| 1990's | 129 (16.41) | 18.2507 |
| 2000's | 212 (26.97) | 29.6817 |
| 2010's | 243 (30.92) | 24.3611 |
| 2020's | 57 (7.25) | 2.80 |
| Authors | Studies |
|---|---|
| Walsh, DA | 1 |
| Sleevi, MC | 1 |
| Sancilio, LF | 1 |
| Wilkerson, WW | 1 |
| Galbraith, W | 1 |
| Gans-Brangs, K | 1 |
| Grubb, M | 1 |
| Hewes, WE | 1 |
| Jaffee, B | 1 |
| Kenney, JP | 1 |
| Kerr, J | 1 |
| Wong, N | 1 |
| Bruno, O | 1 |
| Brullo, C | 1 |
| Ranise, A | 1 |
| Schenone, S | 1 |
| Bondavalli, F | 1 |
| Barocelli, E | 2 |
| Ballabeni, V | 2 |
| Chiavarini, M | 1 |
| Tognolini, M | 2 |
| Impicciatore, M | 2 |
| Yogeeswari, P | 1 |
| Ragavendran, JV | 1 |
| Sriram, D | 1 |
| Nageswari, Y | 1 |
| Kavya, R | 1 |
| Sreevatsan, N | 1 |
| Vanitha, K | 1 |
| Stables, J | 1 |
| Soldi, C | 1 |
| Pizzolatti, MG | 1 |
| Luiz, AP | 1 |
| Marcon, R | 1 |
| Meotti, FC | 1 |
| Mioto, LA | 1 |
| Santos, AR | 2 |
| Pyo, MK | 1 |
| Lee, DH | 2 |
| Kim, DH | 1 |
| Lee, JH | 3 |
| Moon, JC | 1 |
| Chang, KC | 1 |
| Yun-Choi, HS | 1 |
| Venu, TD | 1 |
| Khanum, SA | 1 |
| Firdouse, A | 1 |
| Manuprasad, BK | 1 |
| Shashikanth, S | 1 |
| Mohamed, R | 1 |
| Vishwanth, BS | 1 |
| Chowdhury, MA | 1 |
| Abdellatif, KR | 2 |
| Dong, Y | 1 |
| Das, D | 1 |
| Suresh, MR | 1 |
| Knaus, EE | 1 |
| Zhou, Y | 3 |
| Zhao, M | 2 |
| Wu, Y | 2 |
| Li, C | 2 |
| Wu, J | 2 |
| Zheng, M | 2 |
| Peng, L | 1 |
| Peng, S | 1 |
| Lazzarato, L | 1 |
| Cena, C | 1 |
| Rolando, B | 1 |
| Marini, E | 1 |
| Lolli, ML | 1 |
| Guglielmo, S | 1 |
| Guaita, E | 1 |
| Morini, G | 1 |
| Coruzzi, G | 1 |
| Fruttero, R | 1 |
| Gasco, A | 1 |
| Liu, W | 2 |
| Zhou, J | 2 |
| Zhang, T | 3 |
| Zhu, H | 1 |
| Qian, H | 1 |
| Zhang, H | 7 |
| Huang, W | 4 |
| Gust, R | 1 |
| Zheng, H | 1 |
| Wei, Z | 1 |
| Xin, G | 1 |
| Ji, C | 1 |
| Wen, L | 1 |
| Xia, Q | 1 |
| Niu, H | 1 |
| Bi, W | 1 |
| Bi, Y | 1 |
| Gao, X | 1 |
| Yan, X | 1 |
| Zhang, Y | 15 |
| Harris, J | 1 |
| Legalley, TD | 1 |
| Gibson, KM | 1 |
| Bi, L | 1 |
| Riça, IG | 1 |
| Netto, CD | 1 |
| Rennó, MN | 1 |
| Abreu, PA | 1 |
| Costa, PRR | 1 |
| da Silva, AJM | 1 |
| Cavalcante, MCM | 1 |
| Gogoi, D | 1 |
| Pal, A | 1 |
| Chattopadhyay, P | 1 |
| Paul, S | 1 |
| Deka, RC | 1 |
| Mukherjee, AK | 1 |
| Shi, JB | 1 |
| Chen, LZ | 1 |
| Wang, BS | 1 |
| Huang, X | 2 |
| Jiao, MM | 1 |
| Liu, MM | 1 |
| Tang, WJ | 1 |
| Liu, XH | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 4 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Xu, M | 1 |
| Liu, F | 3 |
| Zhou, W | 1 |
| He, B | 2 |
| Tan, S | 1 |
| Vogelsang, A | 1 |
| Eichler, S | 1 |
| Huntemann, N | 1 |
| Masanneck, L | 1 |
| Böhnlein, H | 1 |
| Schüngel, L | 1 |
| Willison, A | 1 |
| Loser, K | 1 |
| Nieswandt, B | 1 |
| Kehrel, BE | 1 |
| Zarbock, A | 1 |
| Göbel, K | 1 |
| Meuth, SG | 1 |
| Guerrero-Solano, JA | 1 |
| Bautista, M | 1 |
| Velázquez-González, C | 1 |
| De la O-Arciniega, M | 1 |
| González-Olivares, LG | 1 |
| Fernández-Moya, M | 1 |
| Jaramillo-Morales, OA | 1 |
| Silva, JBNF | 1 |
| Calcia, TBB | 1 |
| Silva, CP | 1 |
| Guilherme, RF | 2 |
| Almeida-Souza, F | 1 |
| Lemos, FS | 1 |
| Calabrese, KS | 1 |
| Caruso-Neves, C | 1 |
| Neves, JS | 2 |
| Benjamim, CF | 2 |
| Rodriguez Lanzi, C | 1 |
| Wei, R | 1 |
| Luo, D | 1 |
| Mackenzie, GG | 1 |
| Zhu, D | 1 |
| Zou, H | 1 |
| Liu, J | 2 |
| Wang, J | 6 |
| Ma, C | 1 |
| Yin, J | 2 |
| Peng, X | 1 |
| Li, D | 1 |
| Yang, Y | 3 |
| Ren, Y | 1 |
| Zhang, Z | 1 |
| Zhou, P | 1 |
| Wang, X | 7 |
| Cao, Y | 1 |
| Xu, X | 3 |
| Pansare, K | 1 |
| Mohanty, B | 1 |
| Dhotre, R | 1 |
| Pettiwala, AM | 1 |
| Parab, S | 1 |
| Gupta, N | 1 |
| Gera, P | 1 |
| Gardi, N | 1 |
| Dugge, R | 1 |
| Sahu, P | 1 |
| Alhans, R | 1 |
| Kowtal, P | 1 |
| Chaudhari, P | 1 |
| Sarin, R | 1 |
| Grover, SP | 1 |
| Coughlin, T | 1 |
| Fleifil, SM | 1 |
| Posma, JJN | 1 |
| Spronk, HHM | 1 |
| Heitmeier, S | 1 |
| Owens, AP | 1 |
| Mackman, N | 1 |
| Babu, SSN | 1 |
| Singla, S | 1 |
| Jena, G | 1 |
| Chen, D | 1 |
| Yang, S | 3 |
| Ding, J | 2 |
| Liu, A | 1 |
| Tzelnick, S | 1 |
| Mizrachi, A | 1 |
| Barkan, N | 1 |
| Shivatzki, S | 1 |
| Yosefof, E | 1 |
| Hikri, E | 1 |
| Attias, J | 1 |
| Hilly, O | 1 |
| Guo, Y | 2 |
| Zhu, Y | 3 |
| Sun, Y | 1 |
| Yang, H | 3 |
| Wallen, TE | 1 |
| Youngs, J | 1 |
| Baucom, MR | 1 |
| Turner, K | 1 |
| Schuster, R | 1 |
| England, L | 1 |
| Pritts, TA | 1 |
| Goodman, MD | 2 |
| Kameda, K | 1 |
| Takahashi, E | 1 |
| Kimoto, T | 1 |
| Morita, R | 1 |
| Sakai, S | 1 |
| Nagao, M | 1 |
| Fujisawa, T | 1 |
| Kido, H | 1 |
| Ismail, S | 1 |
| Naveed Mushtaq, M | 1 |
| Shabbir, U | 1 |
| Razzaq, A | 1 |
| Ramzan, HM | 1 |
| Shoukat, A | 1 |
| Ahsan, H | 1 |
| Movafagh, A | 1 |
| Kahrizi, D | 1 |
| Anjum, I | 1 |
| Jiang, Y | 2 |
| Wang, SN | 1 |
| Wu, HT | 1 |
| Qin, HJ | 1 |
| Ren, ML | 1 |
| Lin, JC | 1 |
| Yu, B | 2 |
| Decouture, B | 1 |
| Leuci, A | 1 |
| Dizier, B | 2 |
| Belleville-Rolland, T | 1 |
| Mansour, A | 1 |
| Martin, F | 1 |
| Pidard, D | 1 |
| Gaussem, P | 2 |
| Bachelot-Loza, C | 2 |
| Orieke, D | 1 |
| Ohaeri, OC | 1 |
| Ijeh, II | 1 |
| Ijioma, SN | 1 |
| Zheng, Y | 2 |
| Lieschke, F | 1 |
| Schaefer, JH | 1 |
| Foerch, C | 1 |
| van Leyen, K | 1 |
| Wang, Y | 4 |
| He, G | 1 |
| Tang, H | 1 |
| Shi, Y | 1 |
| Zhu, M | 1 |
| Kang, X | 1 |
| Bian, X | 3 |
| Lyu, J | 1 |
| Zhou, M | 1 |
| Yang, M | 5 |
| Mu, M | 1 |
| Chen, W | 5 |
| Zhou, B | 1 |
| Yuan, C | 1 |
| Zhang, J | 2 |
| Tang, K | 1 |
| Kitahara, M | 1 |
| Seki, K | 1 |
| Midorikawa, T | 1 |
| Arita, J | 1 |
| Uchiyama, A | 1 |
| Wang, Q | 2 |
| Ma, WY | 1 |
| Wang, K | 2 |
| Chang, X | 1 |
| Johnson, ML | 1 |
| Bai, R | 1 |
| Bode, AM | 2 |
| Foster, NR | 1 |
| Falk, GW | 1 |
| Limburg, PJ | 1 |
| Iyer, PG | 1 |
| Dong, Z | 3 |
| Fu, J | 2 |
| Xu, Y | 3 |
| Liu, Y | 7 |
| Ma, L | 3 |
| Bako, HY | 1 |
| Ibrahim, MA | 1 |
| Isah, MS | 1 |
| Ibrahim, S | 1 |
| Fukushima, T | 1 |
| Yokooji, T | 2 |
| Hirano, T | 1 |
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| Taogoshi, T | 1 |
| Matsuo, H | 2 |
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| Luo, Z | 1 |
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| Birnbaum, Y | 2 |
| Tran, D | 1 |
| Chen, H | 3 |
| Nylander, S | 1 |
| Sampaio, LC | 1 |
| Ye, Y | 3 |
| Jiang, X | 3 |
| Liu, X | 5 |
| Wu, X | 2 |
| Jose, PA | 1 |
| Liu, M | 1 |
| Yang, Z | 1 |
| Zhuo, M | 1 |
| Shang, S | 1 |
| Guo, P | 1 |
| Peng, K | 1 |
| Li, M | 3 |
| Mo, P | 1 |
| Qiu, X | 1 |
| Yu, C | 1 |
| Clapper, ML | 1 |
| Chang, WL | 1 |
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| Yellepeddi, VK | 1 |
| Baker, OJ | 2 |
| Smeda, M | 1 |
| Kij, A | 1 |
| Proniewski, B | 1 |
| Matyjaszczyk-Gwarda, K | 1 |
| Przyborowski, K | 1 |
| Jasztal, A | 1 |
| Derszniak, K | 1 |
| Berkowicz, P | 1 |
| Kieronska-Rudek, A | 1 |
| Stojak, M | 1 |
| Sternak, M | 1 |
| Chlopicki, S | 1 |
| Akşit, E | 1 |
| Kurt, T | 1 |
| Büyük, B | 1 |
| Çokkalender, Ö | 1 |
| King, RM | 1 |
| Langan, ET | 1 |
| Ughi, GJ | 1 |
| Raskett, CM | 1 |
| Puri, AS | 1 |
| Henkes, H | 1 |
| Gounis, MJ | 1 |
| Zhao, R | 1 |
| Coker, OO | 1 |
| Zhao, L | 2 |
| Nakatsu, G | 1 |
| Wei, H | 1 |
| Chan, AWH | 1 |
| Sung, JJY | 1 |
| Chan, FKL | 1 |
| El-Omar, E | 1 |
| Yu, J | 3 |
| Ponnusamy, L | 1 |
| Natarajan, SR | 1 |
| Thangaraj, K | 1 |
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| Dludla, PV | 1 |
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| Kane, AM | 1 |
| Liu, C | 1 |
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| McKeone, DM | 1 |
| Bond, CE | 1 |
| Pollock, PM | 1 |
| Young, G | 1 |
| Leggett, BA | 1 |
| Whitehall, VLJ | 1 |
| Wanderer, S | 1 |
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| Wei, W | 1 |
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| Zhang, C | 4 |
| Yu, H | 1 |
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| Guo, Q | 1 |
| Zhen, X | 1 |
| Yu, Y | 1 |
| Deng, J | 1 |
| Han, J | 1 |
| Chen, J | 3 |
| Huang, Q | 1 |
| Qi, X | 1 |
| Liu, Z | 3 |
| Leung, EL | 1 |
| Wang, D | 2 |
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| Oncel, S | 1 |
| Gupta, R | 1 |
| Basson, MD | 1 |
| Wei, M | 1 |
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| Ma, Y | 2 |
| Yin, Z | 2 |
| Chen, B | 2 |
| Dai, H | 1 |
| Wu, D | 3 |
| Cong, J | 1 |
| Ye, L | 1 |
| Liao, C | 1 |
| Ye, Z | 1 |
| Huang, Z | 2 |
| de Abreu, MS | 1 |
| Giacomini, ACVV | 1 |
| Demin, KA | 1 |
| Galstyan, DS | 1 |
| Zabegalov, KN | 1 |
| Kolesnikova, TO | 1 |
| Amstislavskaya, TG | 1 |
| Strekalova, T | 1 |
| Petersen, EV | 1 |
| Kalueff, AV | 1 |
| Feng, Y | 2 |
| Tao, L | 1 |
| Wang, G | 3 |
| He, W | 1 |
| Zhong, X | 1 |
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| D'Agostino, I | 1 |
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| Bruno, A | 1 |
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| Luchetti, BFC | 1 |
| Moreira, NM | 3 |
| Massocatto, CL | 4 |
| Araújo, SM | 2 |
| Sant Ana, DMG | 1 |
| Buttow, NC | 1 |
| Pinge-Filho, P | 3 |
| Araújo, EJA | 2 |
| Ayyadevara, S | 1 |
| Balasubramaniam, M | 1 |
| Kakraba, S | 1 |
| Alla, R | 1 |
| Mehta, JL | 2 |
| Shmookler Reis, RJ | 1 |
| Dai, X | 1 |
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| Fu, X | 1 |
| Pan, Q | 1 |
| Sun, D | 2 |
| Nie, L | 1 |
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| Shen, A | 1 |
| Huang, M | 1 |
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| Geng, M | 2 |
| Yang, RL | 1 |
| Yu, TT | 1 |
| Zhou, YH | 1 |
| Li, CJ | 1 |
| Yang, ZH | 1 |
| Shi, XL | 1 |
| Liu, DL | 1 |
| Shen, B | 1 |
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| Hirono, J | 1 |
| Sanaki, H | 1 |
| Kitada, K | 1 |
| Sada, H | 1 |
| Suzuki, A | 1 |
| Lie, LK | 1 |
| Segi-Nishida, E | 1 |
| Nakagawa, K | 2 |
| Hasegawa, H | 1 |
| Wang, HC | 1 |
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| Grant, NH | 1 |
| Rosenthale, ME | 1 |
| Alburn, HE | 1 |
| Singer, AC | 1 |
| Dolan, MM | 1 |
| Yankell, SL | 1 |
| Friedman, H | 1 |
| Pfeiffer, CJ | 1 |
| Lewandowski, LG | 1 |
| Renaud, S | 1 |
| Godu, J | 1 |
| Byrne, JJ | 1 |
| Migliore, JJ | 1 |
| Beekley, W | 1 |
| Guardione, VA | 1 |
| Williams, LF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Randomized Control Trial of the Effect of Sorafenib Combined With Aspirin in Preventing the Recurrence in High-risk Patients With Hepatocellular Carcinoma[NCT02748304] | 52 participants (Actual) | Interventional | 2016-04-30 | Terminated (stopped due to The enrollment of this study was slow. With the approval of lenvatinib in HCC,many patients choose the new drug, so subsequent enrollment may be more difficult.) | |||
| Comparison of Triflusal With Aspirin in the Secondary Prevention of Atherothrombotic Events[NCT02616497] | Phase 4 | 1,220 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Prasugrel in the Prevention of Severe SARS-CoV2 Pneumonia in Hospitalised Patients[NCT04445623] | Phase 3 | 128 participants (Anticipated) | Interventional | 2020-07-31 | Not yet recruiting | ||
| WilL LOWer Dose Aspirin be More Effective Following ACS? (WILLOW-ACS)[NCT02741817] | Phase 4 | 20 participants (Actual) | Interventional | 2016-06-26 | Completed | ||
| The Effect of Resistant Starch Consumption on Zinc Hemostasis in Malawian Children at Risk for Zinc Deficiency[NCT01811836] | 20 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| GpCRC Pediatric Gastroparesis Registry 2: Characterization and Clinical Course of Symptoms and Gastric Emptying in Pediatric, Adolescent, and Young Adult Participants With Symptoms of Gastroparesis[NCT05981300] | 216 participants (Anticipated) | Observational [Patient Registry] | 2024-02-28 | Not yet recruiting | |||
| Gastrointestinal Ulceration in Patients on Dual Antiplatelet Therapy After Percutaneous Coronary Intervention[NCT00413309] | 30 participants (Anticipated) | Interventional | 2006-04-30 | Completed | |||
| Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer[NCT02418312] | 228 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Pantoprazole Versus Famotidine for the Prevention of Recurrent Peptic Ulcers in Thienopyridine Users - a Double-blind Randomized Controlled Trial[NCT02551744] | 101 participants (Actual) | Interventional | 2012-07-31 | Completed | |||
| Phase 4 Study of Postoperative Prostaglandin E1 in Head and Neck Microsurgery[NCT00733434] | Phase 4 | 242 participants (Anticipated) | Interventional | 2008-07-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Follow-up endoscopy was performed at the end of the 6th month (NCT02418312)
Timeframe: 6 months
| Intervention | participants (Number) |
|---|---|
| Histamine-2 Receptor Antagonist Group | 106 |
| Placebo Group | 101 |
Follow-up endoscopy was performed at the end of the 6th month (NCT02551744)
Timeframe: six month
| Intervention | participants (Number) |
|---|---|
| Proton Pump Inhibitor Group | 1 |
| Histamine-2 Receptor Antagonist Group | 7 |
53 reviews available for aspirin and Disease Models, Animal
| Article | Year |
|---|---|
Dysplastic Aberrant Crypt Foci: Biomarkers of Early Colorectal Neoplasia and Response to Preventive Intervention.
Topics: Aberrant Crypt Foci; Adenoma; Adenomatous Polyposis Coli Protein; Animals; Antineoplastic Agents; As | 2020 |
Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Aspirin; Biological Products; Breast | 2020 |
Unconventional anxiety pharmacology in zebrafish: Drugs beyond traditional anxiogenic and anxiolytic spectra.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Aspirin; Behavior, Animal; Disease Models, Animal; Humans; Ly | 2021 |
Effects of Ultra-Low-Dose Aspirin in Thrombosis and Haemorrhage.
Topics: Animals; Aspirin; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Hemorrhage; Homeopathy; Human | 2019 |
Prevention and intervention trials for colorectal cancer.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; An | 2013 |
Aspirin: a potential therapeutic approach in pancreatic cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Aspirin; Cycloox | 2013 |
Role of platelets in inflammation and cancer: novel therapeutic strategies.
Topics: Animals; Aspirin; Blood Platelets; Cardiovascular Diseases; Colorectal Neoplasms; Cyclooxygenase 2; | 2014 |
Hereditary cancer syndromes as model systems for chemopreventive agent development.
Topics: Adaptor Proteins, Signal Transducing; Adenomatous Polyposis Coli; Adenosine Triphosphatases; Animals | 2016 |
Aspirin treatment for chronic wounds: Potential beneficial and inhibitory effects.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Cyclooxygenase Inhibitor | 2017 |
Sex differences in stroke.
Topics: Acute Disease; Age Factors; Animals; Aspirin; Atrial Fibrillation; Carotid Stenosis; Cerebrovascular | 2008 |
[Pregnancy and antiphospholipid antibodies].
Topics: Animals; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Complemen | 2008 |
Lipoxin and aspirin-triggered lipoxins.
Topics: Animals; Aspirin; Disease Models, Animal; Lipoxins; Lipoxygenase | 2010 |
The effect on mortality of antipyretics in the treatment of influenza infection: systematic review and meta-analysis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspirin; Diclofenac; Disease Models, Animal; Human | 2010 |
Obstetric antiphospholipid syndrome.
Topics: Abortion, Habitual; Animals; Antibodies, Antiphospholipid; Antibody-Dependent Cell Cytotoxicity; Ant | 2012 |
Systematic review and meta-analysis of the effects of antipyretic medications on mortality in Streptococcus pneumoniae infections.
Topics: Animals; Antipyretics; Aspirin; Body Temperature; Disease Models, Animal; Fever; Humans; Pneumococca | 2012 |
Manifold beneficial effects of acetyl salicylic acid and nonsteroidal anti-inflammatory drugs on sepsis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; Dose-Response Rel | 2012 |
Anti-platelet treatment of middle-sized abdominal aortic aneurysms.
Topics: Animals; Aortic Aneurysm, Abdominal; Aspirin; Clinical Trials as Topic; Disease Models, Animal; Dise | 2013 |
Inhibitory effects of acetylsalicylic acid on exocrine pancreatic carcinogenesis.
Topics: Acinar Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Az | 2013 |
Sirolimus-eluting stents: a review of experimental and clinical findings.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Animals; Aspirin; Clopidogrel; Coronary Angiography | 2002 |
Chemoprevention of colorectal cancer--experimental approach and clinical applications.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemoprevention; Colorectal Neoplasms; Cy | 2003 |
Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Case-Control Stu | 2005 |
Therapeutic approaches in arterial thrombosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Atherosclerosis; Blood Pl | 2005 |
Lipoxins and new lipid mediators in the resolution of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Aspirin; Disease Models, Animal | 2006 |
[Molecular pathogenesis and therapeutic targets of lysosomal diseases].
Topics: 1-Deoxynojirimycin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; beta-N-Acetylhexosami | 2007 |
Translational therapeutics at the platelet vascular interface. Summary.
Topics: Angina, Unstable; Animals; Aspirin; Blood Platelets; Clopidogrel; Disease Models, Animal; Drug Evalu | 2008 |
The effect of anticoagulant pharmacotherapy on fracture healing.
Topics: Animals; Anticoagulants; Aspirin; Bone and Bones; Bone Remodeling; Disease Models, Animal; Fondapari | 2008 |
Cardiac death prevention in post-myocardial infarction patients: a review.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Animals; Anti-Arrhythmia Agents; Anticoagu | 1980 |
Pharmacologic problems in shock research.
Topics: Adrenergic alpha-Antagonists; Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Inflammatory Age | 1983 |
Evaluation of platelet-inhibiting drugs in models of atherosclerosis.
Topics: Animals; Arteriosclerosis; Aspirin; Blood Platelets; Cell Division; Disease Models, Animal; Drug Eva | 1982 |
Antiphospholipid syndrome: from the laboratory bench to the patients' bedside.
Topics: Animals; Antiphospholipid Syndrome; Aspirin; Disease Models, Animal; Drug Therapy, Combination; Fema | 1995 |
Summary: leukotrienes as mediators of asthma in humans but not always in experimental animals.
Topics: Animals; Aspirin; Asthma; Disease Models, Animal; Humans; Leukotrienes; Species Specificity | 1994 |
Immunosuppression of experimental systemic lupus erythematosus and antiphospholipid syndrome.
Topics: Adjuvants, Immunologic; Androgens; Animals; Antibodies, Anti-Idiotypic; Antiphospholipid Syndrome; A | 1994 |
[Treatment of multiple organ failure].
Topics: Alprostadil; Animals; Antithrombin III; Aspirin; Blood Component Transfusion; Disease Models, Animal | 1993 |
Does aspirin cause acute or chronic renal failure in experimental animals and in humans?
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Anim | 1996 |
Nonsteroidal anti-inflammatory drugs, eicosanoids, and colorectal cancer prevention.
Topics: Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agent | 1996 |
Hypertension in pregnancy.
Topics: Adult; Animals; Antihypertensive Agents; Aspirin; Disease Models, Animal; Eclampsia; Endothelium, Va | 1997 |
NSAID use and decreased risk of gastrointestinal cancers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; Disease Models, Animal | 1996 |
Aspirin, NSAIDS, and colon cancer prevention: mechanisms?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; Cyclooxygenase 2; Dise | 1998 |
Role of prostaglandins in gastroprotection.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Disease Models, Animal; Gastric Mucosa; Humans; Prostag | 1998 |
A perspective on the potential problems with aspirin as an antithrombotic agent: a comparison of studies in an animal model with clinical trials.
Topics: Animals; Aspirin; Clinical Trials as Topic; Coronary Disease; Disease Models, Animal; Dogs; Fibrinol | 1999 |
Aspirin-triggered 15-epi-lipoxin A4 and stable analogs on lipoxin A4 are potent inhibitors of acute inflammation. Receptors and pathways.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Base Sequence; Bindi | 1999 |
Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediators.
Topics: Amino Acid Sequence; Animals; Aspirin; Dermatitis; Disease Models, Animal; Endothelium; Humans; Hydr | 1999 |
Nonsteroidal anti-inflammatory drugs and the gastrointestinal tract. Extent, mode, and dose dependence of anticancer effects.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Colorectal Neopl | 2001 |
Nonsteroidal anti-inflammatory drugs, low-dose aspirin, and potential ways of reducing the risk of complications.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Disease Models, | 2001 |
Signal transduction pathways: targets for chemoprevention of skin cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Cell Transformat | 2000 |
Von Willebrand's disease.
Topics: Animals; Antibodies; Aspirin; Blood Platelets; Blood Transfusion; Disease Models, Animal; Dogs; Fact | 1976 |
Aspirin-induced gastric mucosal injury: lessons learned from animal models.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Disease Models, Animal; Gastric Mucosa; Prostaglandins; | 1989 |
Progress in Reye syndrome: epidemiology, biochemical mechanisms and animal models.
Topics: Adolescent; Animals; Aspirin; Child; Child, Preschool; Disease Models, Animal; Endotoxins; Escherich | 1989 |
A chronobiologic approach to ethanol and acidified aspirin injury of the gastric mucosa in the rat.
Topics: Animals; Aspirin; Circadian Rhythm; Disease Models, Animal; Ethanol; Gastric Mucosa; Rats | 1987 |
Animal models of osteoarthritis: implication for pathogenesis and treatment.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Aspirin; Chloroquine; Disease Models, An | 1985 |
[The importance of thrombocytes for thrombogenesis and the pharmacological influencing of thrombocyte function (author's transl)].
Topics: Animals; Anticoagulants; Aspirin; Blood Platelet Disorders; Blood Platelets; Clinical Trials as Topi | 1974 |
Arthritis and the working man: hope through research.
Topics: Animals; Arthritis; Arthritis, Infectious; Arthritis, Rheumatoid; Aspirin; Cyclophosphamide; Disease | 1973 |
[Clinical use of non-steroid anti-inflammatory agents].
Topics: Animals; Anti-Inflammatory Agents; Antigen-Antibody Complex; Arthritis, Rheumatoid; Aspirin; Cell Mi | 1974 |
3 trials available for aspirin and Disease Models, Animal
| Article | Year |
|---|---|
Targeting the COX1/2-Driven thromboxane A2 pathway suppresses Barrett's esophagus and esophageal adenocarcinoma development.
Topics: Adenocarcinoma; Animals; Aspirin; Barrett Esophagus; Carcinogenesis; Cell Line, Tumor; Cell Prolifer | 2019 |
Cardiac death prevention in post-myocardial infarction patients: a review.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Animals; Anti-Arrhythmia Agents; Anticoagu | 1980 |
[The importance of thrombocytes for thrombogenesis and the pharmacological influencing of thrombocyte function (author's transl)].
Topics: Animals; Anticoagulants; Aspirin; Blood Platelet Disorders; Blood Platelets; Clinical Trials as Topi | 1974 |
732 other studies available for aspirin and Disease Models, Animal
| Article | Year |
|---|---|
Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Chemical Phenomena; Chemistry | 1984 |
Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disease Models, Animal; D | 1994 |
Synthesis and pharmacological evaluation of 2,5-cycloamino-5H-[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity.
Topics: Adenosine Diphosphate; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Benzopyrans; | 2001 |
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; | 2007 |
Synthetic derivatives of the alpha- and beta-amyrin triterpenes and their antinociceptive properties.
Topics: Analgesics; Animals; Disease Models, Animal; Mice; Molecular Structure; Oleanolic Acid; Pain; Struct | 2008 |
Enantioselective synthesis of (R)-(+)- and (S)-(-)-higenamine and their analogues with effects on platelet aggregation and experimental animal model of disseminated intravascular coagulation.
Topics: Alkaloids; Amides; Animals; Catalysis; Chemistry, Pharmaceutical; Chromatography, High Pressure Liqu | 2008 |
Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines.
Topics: Algorithms; Animals; Animals, Inbred Strains; Anti-Inflammatory Agents, Non-Steroidal; Disease Model | 2008 |
Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeic Acids; Celecoxib; Cy | 2008 |
A class of novel Schiff's bases: Synthesis, therapeutic action for chronic pain, anti-inflammation and 3D QSAR analysis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Chronic Disease; Disease Models, Animal; Ea | 2010 |
Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Collagen; Cyclooxygenase 1; Cyclooxygenase 2; Disease Mo | 2011 |
Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Biological Assay; Breast Neoplasms; Cell L | 2012 |
Preventive effect of a novel diosgenin derivative on arterial and venous thrombosis in vivo.
Topics: Administration, Oral; Animals; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; | 2016 |
Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents; Curcumin; Cytochromes c; Disease Models, Animal; Edema; Enzyme-Li | 2016 |
Anti-inflammatory properties of pterocarpanquinone LQB-118 in mice.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Hydrogen Bonding; Inflammation; Lung Dise | 2016 |
First Report of Plant-Derived β-Sitosterol with Antithrombotic, in Vivo Anticoagulant, and Thrombus-Preventing Activities in a Mouse Model.
Topics: Animals; Anticoagulants; Antithrombins; Catalysis; Disease Models, Animal; Female; Fibrinogen; Human | 2018 |
Novel Pyrazolo[4,3- d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Crystallography, X-Ray; Dimerization; Di | 2019 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Preparation and preliminary quality evaluation of aspirin/L-glutamate compound pellets.
Topics: Animals; Aspirin; Chemistry, Pharmaceutical; Disease Models, Animal; Dose-Response Relationship, Dru | 2021 |
Platelet Inhibition by Low-Dose Acetylsalicylic Acid Reduces Neuroinflammation in an Animal Model of Multiple Sclerosis.
Topics: Animals; Aspirin; Blood Platelets; Brain; CD4-Positive T-Lymphocytes; Disease Models, Animal; Dose-R | 2021 |
Antinociceptive Synergism of Pomegranate Peel Extract and Acetylsalicylic Acid in an Animal Pain Model.
Topics: Analgesics; Animals; Aspirin; Disease Models, Animal; Drug Synergism; Nociceptive Pain; Pain Measure | 2021 |
ATRvD1 Attenuates Renal Tubulointerstitial Injury Induced by Albumin Overload in Sepsis-Surviving Mice.
Topics: Acute Kidney Injury; Albumins; Animals; Aspirin; Biomarkers; Cytokines; Disease Models, Animal; Doco | 2021 |
Phospho-Aspirin (MDC-22) inhibits pancreatic cancer growth in patient-derived tumor xenografts and KPC mice by targeting EGFR: Enhanced efficacy in combination with irinotecan.
Topics: Animals; Antineoplastic Agents; Aspirin; Disease Models, Animal; Drug Therapy, Combination; ErbB Rec | 2022 |
Inhibition of HMGB1 Ameliorates the Maternal-Fetal Interface Destruction in Unexplained Recurrent Spontaneous Abortion by Suppressing Pyroptosis Activation.
Topics: Abortion, Habitual; Adult; Animals; Aspirin; Biomarkers; Decidua; Disease Management; Disease Models | 2021 |
Aspirin Inhibition of Group VI Phospholipase A2 Induces Synthetic Lethality in AAM Pathway Down-Regulated Gingivobuccal Squamous Carcinoma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carcinoma, Squamous Cell; Cell Line, Tumo | 2021 |
Effect of combining aspirin and rivaroxaban on atherosclerosis in mice.
Topics: Animals; Aorta; Apolipoproteins E; Aspirin; Atherosclerosis; Disease Models, Animal; Male; Mice; Mic | 2022 |
Role of Combination Treatment of Aspirin and Zinc in DMH-DSS-induced Colon Inflammation, Oxidative Stress and Tumour Progression in Male BALB/c Mice.
Topics: Animals; Antioxidants; Aspirin; Colitis; Colitis-Associated Neoplasms; Colon; Disease Models, Animal | 2023 |
Natural Flavonoid Quercetin Enhances the Anti-inflammatory Effects of Aspirin in a Preeclampsia-like Rat Model Induced by Lipopolysaccharide.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Disease Models, Animal; Female; Flavonoids; Humans; Lipo | 2023 |
The protective effect of aspirin-induced temporary threshold shift in an animal model of cisplatin-related ototoxicity.
Topics: Animals; Aspirin; Cisplatin; Cochlea; Disease Models, Animal; Mice; Ototoxicity | 2023 |
The preventive effect of low-dose aspirin in a PPAR-γ antagonist treated mouse model of preeclampsia.
Topics: Animals; Aspirin; Disease Models, Animal; Female; Mice; Placenta; PPAR gamma; Pre-Eclampsia; Pregnan | 2022 |
Aspirin Administration Mitigates Platelet Hyperaggregability After Splenectomy in a Murine Model.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Disease Models, Animal; | 2022 |
A Murine Model of Food Allergy by Epicutaneous Adjuvant-Free Allergen Sensitization Followed by Oral Allergen Challenge Combined with Aspirin for Enhanced Detection of Hypersensitivity Manifestations and Immunotherapy Monitoring.
Topics: Adjuvants, Immunologic; Allergens; Animals; Aspirin; Caseins; Cattle; Disease Models, Animal; Female | 2023 |
Evaluation of Hepatoprotective and Gastroprotective Activities of Paspalidium flavidum Leaves Extract in Experimental Animal Models.
Topics: Acetaminophen; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Chemical and Drug Induced Liver In | 2022 |
Aspirin alleviates orthopedic implant‑associated infection.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; Female; Humans; I | 2019 |
Evaluation of commonly used tests to measure the effect of single-dose aspirin on mouse hemostasis.
Topics: Animals; Aspirin; Disease Models, Animal; Drug Evaluation, Preclinical; Hemorrhage; Hemostasis; Male | 2019 |
Gastrointestinal and uterine smooth muscles relaxant and anti-inflammatory effects of corchorus olitorius leaf extract in laboratory animal models.
Topics: Abortion, Spontaneous; Animals; Anti-Inflammatory Agents; Antidiarrheals; Aspirin; Corchorus; Diarrh | 2020 |
Dual Antiplatelet Therapy Increases Hemorrhagic Transformation Following Thrombolytic Treatment in Experimental Stroke.
Topics: Animals; Aspirin; Clopidogrel; Coronary Thrombosis; Disease Models, Animal; Drug Therapy, Combinatio | 2019 |
Aspirin promotes tenogenic differentiation of tendon stem cells and facilitates tendinopathy healing through regulating the GDF7/Smad1/5 signaling pathway.
Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bone Morphogenetic Prote | 2020 |
[The Analgesic Effect of Aspirin on Inflammatory Pain in Rats Is Affected by Pain Intensity and Administration Timing].
Topics: Analgesics; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Pain | 2020 |
Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-κB activation.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Aspirin; Cell Line, Tumor; Disease Models, Anim | 2019 |
Inhibition of JAK-STAT and NF-κB signalling systems could be a novel therapeutic target against insulin resistance and type 2 diabetes.
Topics: Animals; Aspirin; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2019 |
Aspirin enhances sensitization to the egg-white allergen ovalbumin in rats.
Topics: Administration, Oral; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Eg | 2019 |
Aspirin inhibits RANKL-induced osteoclast differentiation in dendritic cells by suppressing NF-κB and NFATc1 activation.
Topics: Animals; Apoptosis; Aspirin; Bone Diseases; Bone Regeneration; CD11c Antigen; Cell Differentiation; | 2019 |
Ticagrelor Improves Remodeling, Reduces Apoptosis, Inflammation and Fibrosis and Increases the Number of Progenitor Stem Cells After Myocardial Infarction in a Rat Model of Ischemia Reperfusion.
Topics: Animals; Apoptosis; Aspirin; Atrial Natriuretic Factor; Disease Models, Animal; Drug Therapy, Combin | 2019 |
Low-Dose Aspirin Treatment Attenuates Male Rat Salt-Sensitive Hypertension via Platelet Cyclooxygenase 1 and Complement Cascade Pathway.
Topics: Animals; Aspirin; Blood Platelets; Blood Pressure; Cells, Cultured; Complement Activation; Cyclooxyg | 2020 |
Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling.
Topics: Anilides; Animals; Aspirin; Carcinogenesis; Cell Proliferation; Colitis; Colorectal Neoplasms; Disea | 2020 |
Predictive modeling of aspirin-triggered resolvin D1 pharmacokinetics for the study of Sjögren's syndrome.
Topics: Administration, Intravenous; Animals; Aspirin; Clinical Trials as Topic; Computer Simulation; Diseas | 2020 |
Unexpected effects of long-term treatment with acetylsalicylic acid on late phase of pulmonary metastasis in murine model of orthotopic breast cancer.
Topics: Animals; Aspirin; Breast Neoplasms; Disease Models, Animal; Disease Progression; Female; Lung Neopla | 2020 |
Drug-eluting Vein Graft with Acetylsalicylic Acid-Ticagrelor-Unfractionated Heparin Complex Inhibits Early Graft Thrombosis
Topics: Animals; Anticoagulants; Aspirin; Coronary Artery Bypass; Disease Models, Animal; Graft Enhancement, | 2020 |
Acute Thrombus Burden on Coated Flow Diverters Assessed by High Frequency Optical Coherence Tomography.
Topics: Acute Disease; Animals; Aspirin; Clopidogrel; Coated Materials, Biocompatible; Disease Models, Anima | 2020 |
Aspirin Reduces Colorectal Tumor Development in Mice and Gut Microbes Reduce its Bioavailability and Chemopreventive Effects.
Topics: Adenomatous Polyposis Coli Protein; Animals; Anti-Bacterial Agents; Anticarcinogenic Agents; Aspirin | 2020 |
Preventive Effects of Neuroprotective Agents in a Neonatal Rat of Photothrombotic Stroke Model.
Topics: Animals; Animals, Newborn; Aspirin; Brain Ischemia; Clopidogrel; Disease Models, Animal; Inflammatio | 2020 |
Clopidogrel Prophylaxis Abates Myocardial Ischemic Injury and Inhibits the Hyperlipidemia-Inflammation Loop in Hypercholestrolemic Mice.
Topics: Animals; Aspirin; Clopidogrel; Disease Models, Animal; Humans; Hypercholesterolemia; Hyperlipidemias | 2020 |
Exploration in the mechanism of rhubarb for the treatment of hyperviscosity syndrome based on network pharmacology.
Topics: Animals; Aspirin; Blood Platelets; Blood Viscosity; Disease Models, Animal; Fibrinogen; Hematologic | 2020 |
Acetylsalicylic acid-like analgesic effects of Trametes versicolor in Wistar rats.
Topics: Analgesics; Animals; Aspirin; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Down-Regulatio | 2020 |
Aspirin Protects Melanocytes and Keratinocytes against UVB-Induced DNA Damage In Vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; DNA Damage; Kerat | 2021 |
Aspirin attenuates YAP and β-catenin expression by promoting β-TrCP to overcome docetaxel and vinorelbine resistance in triple-negative breast cancer.
Topics: Animals; Aspirin; beta Catenin; Cell Cycle Proteins; Disease Models, Animal; Drug Resistance, Neopla | 2020 |
Autophagy assuages myocardial infarction through Nrf2 signaling activation-mediated reactive oxygen species clear.
Topics: Animals; Apoptosis; Aspirin; Autophagy; Autophagy-Related Proteins; Disease Models, Animal; Male; Mi | 2020 |
Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Arrhythmia Agents; Aspirin; Atrial Fibrillation; Atrial | 2021 |
Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1.
Topics: Adenomatous Polyposis Coli; Adenomatous Polyposis Coli Protein; Animals; Aspirin; Disease Models, An | 2021 |
Aspirin modified strontium-doped β-tricalcium phosphate can accelerate the healing of femoral metaphyseal defects in ovariectomized rats.
Topics: 3T3 Cells; Animals; Anti-Inflammatory Agents; Aspirin; Bone Density; Bone Morphogenetic Protein 2; B | 2020 |
Effect of acetylsalicylic acid on inflamed adipose tissue. Insulin resistance and hepatic steatosis in a mouse model of diet-induced obesity.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diet, High-Fat; Disease M | 2021 |
Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Cell Line, Tumor; | 2020 |
Targeting Thymidine Phosphorylase With Tipiracil Hydrochloride Attenuates Thrombosis Without Increasing Risk of Bleeding in Mice.
Topics: Animals; Aspirin; Blood Platelets; Carotid Artery Thrombosis; Chlorocebus aethiops; COS Cells; Disea | 2021 |
Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia.
Topics: Animals; Aspirin; Chemoprevention; Cholecystolithiasis; Cholesterol; Cholesterol, Dietary; Chronic D | 2020 |
The effect of acetylsalicylic acid and pentoxifylline in guinea pigs with non-alcoholic steatohepatitis.
Topics: Animals; Aspirin; Diet, High-Fat; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Reposit | 2021 |
Anti-thrombotic and anti-inflammatory activity of sulodexide compared to aspirin in the rat model.
Topics: Animals; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Disease Models, Animal; Glycosaminoglyca | 2021 |
Rabbit Elastase Aneurysm: Imaging and Histology Correlates for Inflammation and Healing.
Topics: Animals; Aspirin; Carotid Artery Diseases; Carotid Artery, Common; Disease Models, Animal; Disease P | 2021 |
The aberrant expression of CD69 on peripheral T-helper cells in diet-induced inflammation is ameliorated by low-dose aspirin and metformin treatment.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Aspirin; Blood Glucose; Diabetes Mel | 2021 |
Aspirin reduces the incidence of metastasis in a pre-clinical study of Braf mutant serrated colorectal neoplasia.
Topics: Adenoma; Animals; Aspirin; Colorectal Neoplasms; Disease Models, Animal; Female; Incidence; Male; Mi | 2021 |
Aspirin treatment prevents inflammation in experimental bifurcation aneurysms in New Zealand White rabbits.
Topics: Aneurysm; Animals; Aspirin; Disease Models, Animal; Inflammation; Intracranial Aneurysm; Pancreatic | 2022 |
Low-Dose Aspirin Prevents Kidney Damage in LPS-Induced Preeclampsia by Inhibiting the WNT5A and NF-κB Signaling Pathways.
Topics: Animals; Apoptosis; Aspirin; Blood Pressure; Blood Proteins; Cell Line; Cells, Cultured; Disease Mod | 2021 |
Comparison of analgesic activities of aconitine in different mice pain models.
Topics: Acetic Acid; Aconitine; Analgesics; Animals; Aspirin; Disease Models, Animal; Edema; Female; Formald | 2021 |
ZINC40099027 Promotes Gastric Mucosal Repair in Ongoing Aspirin-Associated Gastric Injury by Activating Focal Adhesion Kinase.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Creatini | 2021 |
The Protective Effect of Aspirin against Myocardial Hypertrophy in Rats.
Topics: Animals; Apoptosis; Aspirin; Blood Pressure; Body Weight; Cardiotonic Agents; Disease Models, Animal | 2021 |
Food antigens exacerbate intestinal damage and inflammation following the disruption of the mucosal barrier.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis; Collagen Type II; Disease Models | 2021 |
Aspirin inhibits prostaglandins to prevents colon tumor formation via down-regulating Wnt production.
Topics: Animals; Aspirin; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colitis-Associated Neoplas | 2021 |
Low-dose Aspirin prevents hypertension and cardiac fibrosis when thromboxane A
Topics: Adult; Animals; Antifibrotic Agents; Antihypertensive Agents; Aspirin; Biomarkers; Blood Platelets; | 2021 |
Simultaneous Pretreatment of Aspirin and Omega-3 Fatty Acid Attenuates Nuclear Factor-κB Activation in a Murine Model with Ventilator-Induced Lung Injury.
Topics: Algorithms; Animals; Aspirin; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Fatty | 2021 |
Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis; Colon; Disease Models, Animal; I | 2018 |
Myenteric neuroprotective role of aspirin in acute and chronic experimental infections with Trypanosoma cruzi.
Topics: Animals; Aspirin; Chagas Disease; Cyclooxygenase Inhibitors; Disease Models, Animal; Male; Mice; Mye | 2017 |
Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation.
Topics: Acetylation; Animals; Aspirin; Caenorhabditis elegans; Cell Line; Disease Models, Animal; Humans; Mo | 2017 |
Aspirin Inhibits Cancer Metastasis and Angiogenesis via Targeting Heparanase.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Aspirin; Cell Line, Tumor; Chick Embryo; Di | 2017 |
[Acetylsalicylic acid treatment enhanced immunomodulatory function of mesenchymal stem cells derived from gingiva].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Colitis; Dextran Sulfate; Dise | 2017 |
Effects of aspirin and enoxaparin in a rat model of liver fibrosis.
Topics: Animals; Antithrombins; Aspirin; Disease Models, Animal; Enoxaparin; Liver; Liver Cirrhosis, Experim | 2017 |
Aspirin ameliorates cerebral infarction through regulation of TLR4/NF‑κB‑mediated endoplasmic reticulum stress in mouse model.
Topics: Animals; Apoptosis; Aspirin; Biomarkers; Cerebral Infarction; Disease Models, Animal; Endoplasmic Re | 2018 |
Expression of tissue inhibitor of metalloproteinases and matrix metalloproteinases in the ischemic brain of photothrombosis model mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain; Disease Models, Animal; Endothelia | 2018 |
Direct visualization of microcirculation impairment after acute subdural hemorrhage in a novel animal model.
Topics: Acute Disease; Animals; Aspirin; Blood Gas Monitoring, Transcutaneous; Blood-Brain Barrier; Brain; D | 2018 |
Chronic Mild Hyperhomocysteinemia Alters Inflammatory and Oxidative/Nitrative Status and Causes Protein/DNA Damage, as well as Ultrastructural Changes in Cerebral Cortex: Is Acetylsalicylic Acid Neuroprotective?
Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Catalase; Cerebral | 2018 |
Treatment with low doses of aspirin during chronic phase of experimental Chagas' disease increases oesophageal nitrergic neuronal subpopulation in mice.
Topics: Animals; Aspirin; Chagas Disease; Chronic Disease; Colon; Disease Models, Animal; Esophagus; Male; M | 2017 |
Aspirin Ameliorates Preeclampsia Induced by a Peroxisome Proliferator-Activated Receptor Antagonist.
Topics: Animals; Aspirin; Benzamides; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Fem | 2018 |
Resveratrol combined with total flavones of hawthorn alleviate the endothelial cells injury after coronary bypass graft surgery.
Topics: Animals; Aspirin; Coronary Artery Bypass; Crataegus; Disease Models, Animal; Endothelial Cells; Endo | 2018 |
Monoacylglycerol lipase inhibitor, JZL-184, confers neuroprotection in the mice middle cerebral artery occlusion model of stroke.
Topics: Animals; Aspirin; Behavior, Animal; Benzodioxoles; Brain; Brain Edema; Brain Ischemia; Disease Model | 2018 |
Methanolic Extract of Leathery Murdah, Terminalia coriacea (Roxb.) Wight and Arn. Leaves Exhibits Anti-Inflammatory Activity in Acute and Chronic Models.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug | 2018 |
Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways.
Topics: Actins; Angiotensin II; Animals; Aspirin; beta Catenin; Cell Line; Collagen Type I; Disease Models, | 2018 |
The new plant Parinari kerstingii Engl.: Toxicity studies and anti-inflammatory properties.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Chrysobalanaceae; Disease Models, Animal; D | 2018 |
Prevention Effect of Antiplatelets on Aneurysm Rupture in a Mouse Intracranial Aneurysm Model.
Topics: Aneurysm, Ruptured; Animals; Aspirin; Cerebral Arteries; Cilostazol; Cyclooxygenase 2; Cyclooxygenas | 2018 |
The intervention effect of aspirin on a lipopolysaccharide-induced preeclampsia-like mouse model by inhibiting the nuclear factor-κB pathway.
Topics: Animals; Aspirin; Cell Line, Tumor; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Inter | 2018 |
A Beneficial Effect of Low-Dose Aspirin in a Murine Model of Active Tuberculosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; Mice; Tuberculosi | 2018 |
Genistein Ameliorates Non-alcoholic Fatty Liver Disease by Targeting the Thromboxane A
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Diet, High-Fat; Disease Models, Animal; Disease Progres | 2018 |
Evaluation of the antithrombotic activity of Zhi-Xiong Capsules, a Traditional Chinese Medicinal formula, via the pathway of anti-coagulation, anti-platelet activation and anti-fibrinolysis.
Topics: Acute Disease; Animals; Anticoagulants; Antithrombins; Aspirin; Blood Coagulation; Capsules; Carotid | 2018 |
Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARα.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal | 2018 |
Ameliorative effects of aspirin against lipopolysaccharide-induced preeclampsia-like symptoms in rats by inhibiting the pro-inflammatory pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cytokines; Disease Models, Animal; Down-R | 2018 |
Macrophages confer resistance to PI3K inhibitor GDC-0941 in breast cancer through the activation of NF-κB signaling.
Topics: Animals; Aspirin; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Dise | 2018 |
Studies on Prostaglandin-Endoperoxide Synthase 1: Lower Levels in Schizophrenia and After Treatment with Antipsychotic Drugs in Conjunction with Aspirin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Aspirin; Bipolar Disorder; B | 2018 |
Nitroglycerin application and coronary arteriogenesis.
Topics: Animals; Aorta, Thoracic; Aspirin; Coronary Occlusion; Coronary Vessels; Disease Models, Animal; Hum | 2018 |
Comparative analgesic evaluation of Himalrandia tetrasperma and Wendlandia exserta of family Rubiaceae after induction of pain in mice.
Topics: Acetic Acid; Analgesics; Animals; Aspirin; Behavior, Animal; Disease Models, Animal; Hot Temperature | 2018 |
Aspirin eugenol ester regulates cecal contents metabolomic profile and microbiota in an animal model of hyperlipidemia.
Topics: Animals; Aspirin; Cecum; Diet; Disease Models, Animal; Eugenol; Gastrointestinal Microbiome; Hyperli | 2018 |
Time-Dependent Hypotensive Effect of Aspirin in Mice.
Topics: Animals; Antihypertensive Agents; ARNTL Transcription Factors; Aspirin; Blood Platelets; Blood Press | 2018 |
Aspirin treatment does not increase microhemorrhage size in young or aged mice.
Topics: Age Factors; Aging; Animals; Arterioles; Aspirin; Cerebral Cortex; Cerebral Hemorrhage; Disease Mode | 2019 |
Gastroprotective and antioxidant potential of Euphorbia prostrata against aspirin induced gastric ulcers in rabbits.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Cimetidine; Cytoprotection; Disease Models, Anima | 2019 |
Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity.
Topics: Acetylation; Amino Acid Sequence; Animals; Aspirin; Autoimmune Diseases; Autoimmune Diseases of the | 2019 |
Plant latex thrombin-like cysteine proteases alleviates bleeding by bypassing factor VIII in murine model.
Topics: Animals; Asclepias; Aspirin; Calotropis; Carica; Cysteine Endopeptidases; Disease Models, Animal; Fa | 2019 |
Aspirin-triggered proresolving mediators stimulate resolution in cancer.
Topics: Animals; Antineoplastic Agents; Aspirin; Chemokine CCL2; Chemokines; Cytokines; Disease Models, Anim | 2019 |
Aspirin Triggered Resolvin D1 reduces inflammation and restores saliva secretion in a Sjögren's syndrome mouse model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cytokines; Disease Models, Animal; Docosa | 2019 |
Involvement of the anti-inflammatory, anti-apoptotic, and anti-secretory activity of bee venom in its therapeutic effects on acetylsalicylic acid-induced gastric ulceration in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Apoptosis; Aspirin; bcl-2-Associ | 2019 |
Antithrombotic Activity of a Novel Diazepino[1,2-α] Benzimidazole Derivative on Arterial Thrombosis Model in Rats without Concomitant Pathology and in Rats with Experimental Myocardial Infarction.
Topics: Animals; Animals, Outbred Strains; Aspirin; Azepines; Benzimidazoles; Blood Coagulation Tests; Chlor | 2019 |
Local administration of aspirin with β-tricalcium phosphate/poly-lactic-co-glycolic acid (β-TCP/PLGA) could enhance osteoporotic bone regeneration.
Topics: Animals; Aspirin; Biomarkers; Biomechanical Phenomena; Bone Regeneration; Calcium Phosphates; Diseas | 2019 |
Thrombus targeting aspirin particles for near infrared imaging and on-demand therapy of thrombotic vascular diseases.
Topics: Animals; Aspirin; Cytokines; Disease Models, Animal; Fibrinolytic Agents; Hemorrhage; Hydrogen Perox | 2019 |
Ameliorative effects of pre-eclampsia by quercetin supplement to aspirin in a rat model induced by L-NAME.
Topics: Animals; Aspirin; Blood Pressure; Cytokines; Dietary Supplements; Disease Models, Animal; Female; In | 2019 |
Effect of acetylsalicylic acid on total myenteric neurons in mice experimentally infected with Trypanosoma cruzi.
Topics: Animals; Aspirin; Chagas Disease; Chronic Disease; Disease Models, Animal; Male; Mice; Myenteric Ple | 2019 |
UPLC-Q-TOF/MS-Based Plasma Metabolomics to Evaluate the Effects of Aspirin Eugenol Ester on Blood Stasis in Rats.
Topics: Animals; Aspirin; Blood; Blood Chemical Analysis; Blood Coagulation; Blood Viscosity; Chromatography | 2019 |
The Role of Chemoprophylactic Agents in Modulating Platelet Aggregability After Traumatic Brain Injury.
Topics: Amitriptyline; Animals; Aspirin; Blood Coagulation; Brain Injuries, Traumatic; Disease Models, Anima | 2019 |
Anti-inflammatory effects of essential oil in Echinacea purpurea L.
Topics: Albumins; Animals; Anti-Inflammatory Agents; Aspirin; Cotton Fiber; Disease Models, Animal; Distilla | 2013 |
Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Fruit; Gastric Acid; G | 2013 |
Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Cyclophos | 2013 |
Chronic aspirin via dose-dependent and selective inhibition of cardiac proteasome possibly contributed a potential risk to the ischemic heart.
Topics: Animals; Aspirin; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship | 2013 |
Protective role of acetylsalicylic acid in experimental Trypanosoma cruzi infection: evidence of a 15-epi-lipoxin A₄-mediated effect.
Topics: Animals; Aspirin; Cell Line; Chagas Disease; Disease Models, Animal; Lipoxins; Male; Mice; Mice, Inb | 2013 |
Angiotensin II Type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Arthritis, Experimental; Aspirin; Charyb | 2013 |
Protection of vascular endothelium by aspirin in a murine model of chronic Chagas' disease.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Chagas Cardiomyopathy; Chronic Disease; Disease Models, | 2013 |
Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats.
Topics: Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Biomarkers; Cerul | 2013 |
Aspirin minimized the pro-metastasis effect of sorafenib and improved survival by up-regulating HTATIP2 in hepatocellular carcinoma.
Topics: Acetyltransferases; Animals; Aspirin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferatio | 2013 |
Anti-platelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma.
Topics: Animals; Aspirin; Blood Platelets; Carcinoma, Hepatocellular; CD8-Positive T-Lymphocytes; Cell Proli | 2013 |
The role of food for the formation and prevention of gastrointestinal lesions induced by aspirin in cats.
Topics: Administration, Oral; Animals; Aspirin; Cats; Cimetidine; Diet; Dietary Fiber; Disease Models, Anima | 2013 |
Animal models of gastric bleeding induced by dual antiplatelet therapy using aspirin and clopidogrel--prophylactic effect of antiulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Drug Synergism; Histamine | 2014 |
Pulmonary antifibrotic mechanisms aspirin-triggered lipoxin A(4) synthetic analog.
Topics: Animals; Arginase; Aspirin; Biomarkers; Bleomycin; Bronchoalveolar Lavage Fluid; Cell Count; Cytokin | 2013 |
Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers.
Topics: Alcohols; Alkaloids; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Cold Temperature; Disease Mo | 2013 |
Oral chemoprevention with acetyl salicylic Acid, vitamin D and calcium reduces the risk of tobacco carcinogen-induced bladder tumors in mice.
Topics: Administration, Oral; Animals; Aspirin; Calcium; Calcium, Dietary; Carcinogens; Disease Models, Anim | 2013 |
Antiplatelet loading improves behavioral outcome in a rabbit model of stroke.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Brain Ischemia; Collagen | 2013 |
Aspirin prolongs survival and reduces the number of Foxp3+ regulatory T cells in a genetically engineered mouse model of pancreatic cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Aspirin; Carcinoma, Pancreatic Ductal; Cyclooxygenase Inhi | 2013 |
Low-dose aspirin and ibuprofen's sterilizing effects on Mycobacterium tuberculosis suggest safe new adjuvant therapies for tuberculosis.
Topics: Adjuvants, Pharmaceutic; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; As | 2013 |
A novel combinatorial nanotechnology-based oral chemopreventive regimen demonstrates significant suppression of pancreatic cancer neoplastic lesions.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemot | 2013 |
Angiogenic impairment of the vascular endothelium: a novel mechanism and potential therapeutic target in muscular dystrophy.
Topics: Animals; Apoptosis; Aspirin; Carcinoma, Lewis Lung; Caveolin 1; Cell Movement; Cell Proliferation; C | 2013 |
Neuroprotective effect of a new synthetic aspirin-decursinol adduct in experimental animal models of ischemic stroke.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzopyrans; Butyrates; Disease Models, A | 2013 |
Protective role of aspirin, vitamin C, and zinc and their effects on zinc status in the DMH-induced colon carcinoma model.
Topics: 1,2-Dimethylhydrazine; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antio | 2013 |
Chemoprevention with acetylsalicylic acid, vitamin D and calcium reduces risk of carcinogen-induced lung tumors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bone Density Conservation Agents; Calcium | 2013 |
Antiplatelet drugs reduce the immunoinflammatory response in a rat model of periodontal disease.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Aspirin; Clopidogrel; Collagen; Connective Ti | 2014 |
Effect of simvastatin on inflammatory cytokines balance in air pouch granuloma model.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; C-Reactive Protein; Cells, Cultured; Cytokines; Disease | 2014 |
Neurovascular protection of cilostazol in stroke-prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation.
Topics: Animals; Antigens; Aspirin; Cerebrovascular Circulation; Cilostazol; Clopidogrel; Disease Models, An | 2014 |
Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression.
Topics: Adipogenesis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; beta Catenin; Bone Marrow C | 2014 |
The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC(Min/+) mice.
Topics: Adenocarcinoma; Adenomatous Polyposis Coli; Administration, Oral; Animals; Anti-Inflammatory Agents; | 2014 |
Low-dose aspirin ameliorated hyperlipidemia, adhesion molecule, and chemokine production induced by high-fat diet in Sprague-Dawley rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Aspirin; Atherosclerosis; Blood P | 2014 |
Perioperative aspirin improves neurological outcome after focal brain ischemia possibly via inhibition of Notch 1 in rat.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Infarction; D | 2014 |
Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Blood Ur | 2014 |
Effect of aspirin treatment on the prevention of esophageal adenocarcinoma in a rat experimental model.
Topics: Adenocarcinoma; Animals; Aspirin; Barrett Esophagus; Dinoprostone; Disease Models, Animal; Esophagea | 2014 |
Aspirin inhibits proliferation and induces apoptosis of multiple myeloma cells through regulation of Bcl-2 and Bax and suppression of VEGF.
Topics: Animals; Antineoplastic Agents; Apoptosis; Aspirin; bcl-2-Associated X Protein; Caspases; Cell Line, | 2014 |
Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo.
Topics: Animals; Aspartic Acid Endopeptidases; Aspirin; Carbamates; Cell Fractionation; Cells, Cultured; Dip | 2014 |
Aspirin but not meloxicam attenuates early atherosclerosis in apolipoprotein E knockout mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apolipoproteins E; Aspirin; Atherosclerosis; Cyclo | 2014 |
Aspirin-triggered Lipoxin A4 attenuates mechanical allodynia in association with inhibiting spinal JAK2/STAT3 signaling in neuropathic pain in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Astrocytes; Constriction, Pathologic; Dis | 2014 |
Celecoxib increases miR-222 while deterring aromatase-expressing breast tumor growth in mice.
Topics: Animals; Apoptosis; Aromatase; Aspirin; Body Weight; Breast Neoplasms; Celecoxib; Cell Cycle; Cycloo | 2014 |
Enalapril and ASS inhibit tumor growth in a transgenic mouse model of islet cell tumors.
Topics: Adenoma, Islet Cell; Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Anima | 2014 |
Extrahepatic platelet-derived growth factor-β, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Aspirin; | 2014 |
Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: evidence from an animal model and a human cohort.
Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asbestos; Aspirin; Chemoprevention; Cohort S | 2014 |
Acetylsalicylic acid mitigates erythropoietin-associated blood pressure increase in nonuremic rats.
Topics: Anemia; Animals; Aspirin; Blood Pressure; Disease Models, Animal; Drug Monitoring; Erythropoietin; H | 2015 |
Identification of quinoline-chalcone hybrids as potential antiulcer agents.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Chalcone; Disease Models, Animal; Dose-Re | 2015 |
Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Gastric Acid; Gas | 2014 |
Development of a subcutaneous endometriosis rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Hormonal; Aspirin; Connecti | 2015 |
Low-dose aspirin (acetylsalicylate) prevents increases in brain PGE2, 15-epi-lipoxin A4 and 8-isoprostane concentrations in 9 month-old HIV-1 transgenic rats, a model for HIV-1 associated neurocognitive disorders.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain; Dinoprost; Dinoprostone; Disease M | 2015 |
The postulated mechanism of the protective effect of ginger on the aspirin induced gastric ulcer: Histological and immunohistochemical studies.
Topics: Animals; Anti-Ulcer Agents; Aspirin; bcl-2-Associated X Protein; Disease Models, Animal; Gastric Muc | 2015 |
Antioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasia.
Topics: Achondroplasia; Animals; Anti-Inflammatory Agents; Antioxidants; Aspirin; Cartilage Oligomeric Matri | 2015 |
Kaempferol, a dietary flavonoid, ameliorates acute inflammatory and nociceptive symptoms in gastritis, pancreatitis, and abdominal pain.
Topics: Abdominal Pain; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ceruletide; | 2015 |
Coadministration of the Human Umbilical Cord Matrix-Derived Mesenchymal Cells and Aspirin Alters Postischemic Brain Injury in Rats.
Topics: Adipogenesis; Analysis of Variance; Animals; Aspirin; Brain Injuries; Brain Ischemia; Cell Different | 2015 |
Cilostazol, Not Aspirin, Prevents Stenosis of Bioresorbable Vascular Grafts in a Venous Model.
Topics: Absorbable Implants; Animals; Aspirin; Blood Vessel Prosthesis; Cell Proliferation; Cilostazol; Dise | 2015 |
Preventive Effect of Aspirin Eugenol Ester on Thrombosis in κ-Carrageenan-Induced Rat Tail Thrombosis Model.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Carrageenan; Disease Models, Animal; Eryth | 2015 |
Aspirin Suppresses the Growth and Metastasis of Osteosarcoma through the NF-κB Pathway.
Topics: Animals; Apoptosis; Aspirin; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Ce | 2015 |
Synthesis and Analgesic Activity of Annelated Xanthine Derivatives in Experimental Models in Rodents.
Topics: Analgesics; Animals; Aspirin; Behavior, Animal; Cell Proliferation; Cell Survival; Disease Models, A | 2015 |
Aspirin plus ticlopidine prevented experimental endocarditis due to Enterococcus faecalis and Streptococcus gallolyticus.
Topics: Animals; Aspirin; Disease Models, Animal; Endocarditis, Bacterial; Enterococcus faecalis; Female; Gr | 2015 |
Sodium Cromoglycate Prevents Exacerbation of IgE-Mediated Food-Allergic Reaction Induced by Aspirin in a Rat Model of Egg Allergy.
Topics: Administration, Oral; Allergens; Anaphylaxis; Animals; Aspirin; Cromolyn Sodium; Disease Models, Ani | 2015 |
Experimental evaluation of anti-inflammatory, antinociceptive and antipyretic activities of clove oil in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Aspirin; Clove Oil; Disease Models, Ani | 2015 |
The effects of aspirin, flurbiprofen, and NO-donating acetylsalicylic acid (NCX 4016) on mice models of endotoxic and septic shock.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; Flurbiprofen; Liv | 2015 |
Aspirin Attenuates Angiotensin II-induced Cardiomyocyte Hypertrophy by Inhibiting the Ca(2+)/Calcineurin-NFAT Signaling Pathway.
Topics: Angiotensin II; Animals; Animals, Newborn; Aspirin; Atrial Natriuretic Factor; Calcineurin; Calcium; | 2016 |
The Influence of Prolonged Acetylsalicylic Acid Supplementation-Induced Gastritis on the Neurochemistry of the Sympathetic Neurons Supplying Prepyloric Region of the Porcine Stomach.
Topics: Animals; Aspirin; Dietary Supplements; Disease Models, Animal; Female; Ganglia, Sympathetic; Gastric | 2015 |
Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling.
Topics: Animals; Aspirin; beta Catenin; Cells, Cultured; Cyclooxygenase Inhibitors; Disease Models, Animal; | 2015 |
Histopathological evaluation of gastro protective effect of Berberis vulgaris (Zereshk) seeds against aspirin induced ulcer in albino mice.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Berberis; Cell Proliferatio | 2015 |
Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Aspirin; Behavior, Animal; | 2016 |
Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease.
Topics: Animals; Aspirin; Atrophy; Chagas Disease; Chronic Disease; Cyclooxygenase Inhibitors; Disease Model | 2017 |
Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells.
Topics: Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Asp | 2016 |
Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adult; Animals; Aspirin; Blood Coagulation; Blood Pl | 2016 |
Neutrophils influx and proinflammatory cytokines inhibition by sodium salicylate, unlike aspirin, in Candida albicans-induced peritonitis model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Candidiasis; Cytokines; Disease Models, A | 2016 |
Effect of aspirin on models of retinal pigment epithelium pathology.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Chemokine CCL2; Choroidal Neov | 2016 |
Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk.
Topics: Animals; Aspirin; Atrial Fibrillation; Bleeding Time; Carotid Artery Diseases; Case-Control Studies; | 2016 |
Role of thromboxane-dependent platelet activation in venous thrombosis: Aspirin effects in mouse model.
Topics: Animals; Aspirin; Blood Platelets; Cell-Derived Microparticles; Disease Models, Animal; Male; Mice; | 2016 |
Sodium Sulfide, a Hydrogen Sulfide-Releasing Molecule, Attenuates Acute Cerebral Ischemia in Rats.
Topics: Acute Disease; Analysis of Variance; Animals; Apoptosis; Aspirin; Blood Pressure; Cell Survival; Cel | 2016 |
Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Aspirin; Cyclooxygenase Inhibitors; Disease Models, An | 2016 |
Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia.
Topics: Acute Lung Injury; Animals; Aspirin; Blotting, Western; Disease Models, Animal; Fatty Acids, Unsatur | 2016 |
A rabbit model of cerebral microembolic signals for translational research: preclinical validation for aspirin and clopidogrel.
Topics: Animals; Aspirin; Carotid Artery Thrombosis; Chlorides; Clopidogrel; Disease Models, Animal; Drug Ev | 2016 |
Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice.
Topics: Aneurysm, Ruptured; Animals; Aspirin; Cerebral Arteries; Cyclooxygenase 2; Cyclooxygenase Inhibitors | 2016 |
Aspirin and Clopidogrel Inhibit Aneurysm Healing after HydroCoil Implantation in External Carotid Artery Aneurysm Model.
Topics: Aneurysm; Animals; Aspirin; Carotid Artery Diseases; Carotid Artery, External; Cell Movement; Clopid | 2016 |
Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Chronic Pain; Disease Mo | 2016 |
Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Biomarkers; Cell Line, | 2016 |
A novel co-drug of aspirin and ursolic acid interrupts adhesion, invasion and migration of cancer cells to vascular endothelium via regulating EMT and EGFR-mediated signaling pathways: multiple targets for cancer metastasis prevention and treatment.
Topics: Animals; Aspirin; Biomarkers; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Disease | 2016 |
Impact of different antithrombotics on the microcirculation and viability of perforator-based ischaemic skin flaps in a small animal model.
Topics: Animals; Aspirin; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Graft Survival; Heparin; | 2016 |
Aspirin-Based Carbon Dots, a Good Biocompatibility of Material Applied for Bioimaging and Anti-Inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biocompatible Materials; Bone Marrow Cell | 2016 |
Protective effects of levamisole, acetylsalicylic acid, and α-tocopherol against dioxin toxicity measured as the expression of AhR and COX-2 in a chicken embryo model.
Topics: alpha-Tocopherol; Animals; Aspirin; Brain; Chick Embryo; Chickens; Cyclooxygenase 2; Dioxins; Diseas | 2017 |
Investigations on anti-inflammatory and analgesic activities of Alnus nitida Spach (Endl). stem bark in Sprague Dawley rats.
Topics: Alnus; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Chromatography, High Pressure Liquid; | 2017 |
Improved Pig Model to Evaluate Heart Valve Thrombosis.
Topics: Animals; Aspirin; Blood Coagulation; Blood Platelets; Clopidogrel; Disease Models, Animal; Heart Val | 2016 |
Prothrombotic and hemorrhagic effects of aspirin.
Topics: Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Hemorrhage; Rats; Substa | 2009 |
VEGF expression and the effect of NSAIDs on ascites cell proliferation in the hen model of ovarian cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascites; Aspirin; Cell Growth Processes; Chickens; | 2008 |
Enhancement of anti-inflammatory property of aspirin in mice by a nano-emulsion preparation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Croton Oil; Disease Models, Animal; Drug | 2008 |
Inhibition of chemically induced inflammation and pain by orally and topically administered leaf extract of Manihot esculenta Crantz in rodents.
Topics: Administration, Cutaneous; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Aspi | 2008 |
Antioxidative action of aspirin on endothelial function in hypercholesterolaemic rats.
Topics: Animals; Antioxidants; Aorta, Thoracic; Aspirin; Cholesterol; Disease Models, Animal; Endothelium, V | 2008 |
Influence of protein malnutrition on induction and treatment of inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Diclofenac; Diet, Protein-Re | 2006 |
Antiatherosclerotic activity of ibuprofen, a non-selective COX inhibitor--an animal study.
Topics: Animals; Anti-Inflammatory Agents; Antiparasitic Agents; Aspirin; Atherosclerosis; Celecoxib; Diseas | 2008 |
Effect of chronic aspirin administration on an experimental model of metabolic syndrome.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aspirin; Blood Glucose; Blood Pressure; Bod | 2009 |
Effects of combination of calcium and aspirin on azoxymethane-induced aberrant crypt foci formation in the colons of mice and rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azoxymethane; Calcium, Dietary; Carcinoge | 2008 |
Fatty aspirin: a new perspective in the prevention of dementia of Alzheimer's type?
Topics: Alzheimer Disease; Animals; Antioxidants; Aspirin; Cognition Disorders; Dementia; Disease Models, An | 2008 |
Short- and long-term efficacy of aspirin and clopidogrel for thromboprophylaxis for mechanical heart valves: an in vivo study in swine.
Topics: Administration, Oral; Animals; Aspirin; Bioprosthesis; Clopidogrel; Dalteparin; Disease Models, Anim | 2008 |
Dietary aspirin decreases the stage of ovarian cancer in the hen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chickens; Diet; Dinoprostone; Disease Mod | 2009 |
Association between the efficacy of dual antiplatelet therapy and the development of in-stent neointimal hyperplasia in porcine coronary arteries.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Animals; Aspirin; Cell Proliferation; Clopido | 2008 |
Effects of aspirin and celecoxib on rigidity in a rat model of Parkinson's disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygena | 2007 |
Delayed neonatal closure of the ductus arteriosus following early in utero exposure to indomethacin in the rat.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibito | 2009 |
Protective effects of electroacupuncture on acetylsalicylic acid-induced acute gastritis in rats.
Topics: Animals; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Electroacupuncture; Ga | 2009 |
Long-term clopidogrel administration following severe coronary injury reduces proliferation and inflammation via inhibition of nuclear factor-kappaB and activator protein 1 activation in pigs.
Topics: Animals; Aspirin; Clopidogrel; Coronary Restenosis; Disease Models, Animal; Drug Therapy, Combinatio | 2009 |
Salicylates dilate blood vessels through inhibiting PYK2-mediated RhoA/Rho-kinase activation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Aspirin; Blood Pressure; Blood Ve | 2009 |
Neuroprotective effects of Kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia in rats.
Topics: Animals; Aspirin; Brain Ischemia; Cell Death; Disease Models, Animal; Dose-Response Relationship, Dr | 2009 |
Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Disease Models, Animal; Edema; F | 2009 |
Antinociceptive activity of Amaranthus spinosus in experimental animals.
Topics: Acetic Acid; Amaranthus; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carr | 2009 |
Curcumin potentiates the anti-inflammatory activity of cyclooxygenase inhibitors in the cotton pellet granuloma pouch model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Curcumin; Cyclooxygenase 2 Inhibitors; Cy | 2009 |
The analgesic effect of decursinol.
Topics: Acetaminophen; Acetic Acid; Analgesics; Angelica; Animals; Aspirin; Benzopyrans; Butyrates; Disease | 2009 |
Investigation of neuroprotective effects of cyclooxygenase inhibitors in the 6-hydroxydopamine induced rat Parkinson model.
Topics: Amphetamines; Animals; Antiparkinson Agents; Apomorphine; Aspirin; Behavior, Animal; Cyclooxygenase | 2009 |
Combination treatment with ethyl pyruvate and aspirin enhances neuroprotection in the postischemic brain.
Topics: Animals; Aspirin; Astringents; Astrocytes; Brain Infarction; Cells, Cultured; Cerebral Cortex; Cytok | 2010 |
The efficacy of Ankaferd Blood Stopper in antithrombotic drug-induced primary and secondary hemostatic abnormalities of a rat-bleeding model.
Topics: Analysis of Variance; Animals; Anticoagulants; Aspirin; Disease Models, Animal; Enoxaparin; Female; | 2009 |
The cyclooxygenase-2 selective inhibitor, etodolac, but not aspirin reduces neovascularization in a murine ischemic hind limb model.
Topics: Animals; Aspirin; Bone Marrow Cells; Cell Transplantation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclo | 2010 |
The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer.
Topics: Amylases; Angiotensin-Converting Enzyme Inhibitors; Animals; Anticarcinogenic Agents; Aspirin; Carci | 2010 |
Anti-ulcer role of herbomineral Siddha drug - Thamira parpam on experimentally induced gastric mucosal damage in rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Body Weight; Cytoprotection; Disease Models, Anim | 2010 |
Aspirin therapy: an attempt to explain the events of prothrombotic complications after treatment discontinuation.
Topics: Animals; Aspirin; Blood Coagulation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors | 2010 |
Endoscopic application of hemostatic thrombin-gelatin matrix (FloSeal) in anticoagulated pigs.
Topics: Animals; Anticoagulants; Aspirin; Blood Coagulation Disorders; Disease Models, Animal; Endoscopy; Ga | 2010 |
Synthesis and evaluation of novel 2-substituted-quinazolin-4(3H)-ones as potent analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Disease Models, Animal; Female; Indomethacin | 2010 |
Screening agents for preventive efficacy in a bladder cancer model: study design, end points, and gefitinib and naproxen efficacy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Cyclooxygenase Inh | 2010 |
Neuroprotective effects vary across nonsteroidal antiinflammatory drugs in a mouse model of developing excitotoxic brain injury.
Topics: Acetaminophen; Adrenal Cortex Hormones; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Ste | 2010 |
[Effects of danhong injection on experimental atherosclerosis rabbit model and its mechanism].
Topics: Animals; Aorta; Aspirin; Atherosclerosis; Carthamus tinctorius; Cholesterol; Disease Models, Animal; | 2009 |
Novel conjugates of aspirin with phenolic acid as anti-inflammatory agents having significantly reduced gastrointestinal toxicity.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aspirin; Biphenyl Compounds; Croton Oil; Disease Mo | 2010 |
Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung.
Topics: Adenosine; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Disease Mod | 2010 |
Gastroprotective effect of earthworm paste (Lampito mauritii, Kinberg) on experimental gastric ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cytoprotection; Disease Models, Animal; Dose-Response Relations | 2010 |
Modelling a dream: the molecular prevention of pancreatic cancer.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Disease Models, Animal; Drug Therapy, Combination; Enalap | 2010 |
Cytosolic phospholipase A2alpha mediates Pseudomonas aeruginosa LPS-induced airway constriction of CFTR -/- mice.
Topics: Administration, Intranasal; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Bronchoalveolar L | 2010 |
Protective effect of irbesartan, an angiotensin II receptor antagonist, alone and in combination with aspirin on middle cerebral artery occlusion model of focal cerebral ischemia in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Aspirin; Biphenyl Compounds; Brain I | 2011 |
Effects of Danshensu on maternal syndrome in phosphatidylserine/phosphatidylcholine microvesicle induced-mouse model: is it a candidate for preeclampsia remedy?
Topics: Animals; Anticoagulants; Aspirin; Disease Models, Animal; Female; Heparin; Lactates; Mice; Mice, Inb | 2010 |
New method of inducing intestinal lesions in rats by intraduodenal administration of aspirin.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; | 2010 |
Moringa oleifera induced potentiation of serotonin release by 5-HT(3) receptors in experimental ulcer model.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Enterochromaffin Cells; Female; Male; M | 2011 |
Combinatorial chemoprevention reveals a novel smoothened-independent role of GLI1 in esophageal carcinogenesis.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Aspirin; Barrett Esophagus; Cell Growth Processes; | 2010 |
Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel.
Topics: Animals; Aspirin; Carotid Arteries; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; | 2010 |
Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as safe anti-inflammatory, analgesic, antipyretic, antioxidant prodrugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Antipyretics; Aspirin; Dinoprostone; | 2010 |
Cilostazol prevents amyloid β peptide(25-35)-induced memory impairment and oxidative stress in mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspirin; Avoidance Learning; Cilostazol; Cytokine | 2010 |
NO-donating aspirin and aspirin partially inhibit age-related atherosclerosis but not radiation-induced atherosclerosis in ApoE null mice.
Topics: Age Factors; Animals; Apolipoproteins E; Aspirin; Atherosclerosis; Carotid Arteries; Disease Models, | 2010 |
Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway.
Topics: Animals; Apoptosis; Aspirin; bcl-X Protein; Body Weight; Colorectal Neoplasms; Disease Models, Anima | 2011 |
Effects of COX inhibitors on neurodegeneration and survival in mice exposed to the marine neurotoxin domoic acid.
Topics: Animals; Aspirin; Cell Survival; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Administrat | 2011 |
Favorable maternal and fetal effects of danshensu in an experimental mice model of preeclampsia.
Topics: Animals; Anticoagulants; Aspirin; Blood Pressure; Disease Models, Animal; Drugs, Chinese Herbal; Fem | 2011 |
Elucidation of possible mechanism of analgesic action of Valeriana wallichii DC chemotype (patchouli alcohol) in experimental animal models.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asp | 2010 |
Role of intramural platelet thrombus in the pathogenesis of wall rupture and intra-ventricular thrombosis following acute myocardial infarction.
Topics: Animals; Aspirin; Blood Platelets; Clopidogrel; Disease Models, Animal; Hemodynamics; Inflammation; | 2011 |
Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5-hydroxytryptamine levels.
Topics: Animals; Aspirin; Blood Pressure; Body Weight; Disease Models, Animal; Heart Rate; Hemodynamics; Hyp | 2011 |
Influence of anti-inflammatory and vasoactive drugs on microcirculation and angiogenesis after burn in mice.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Burns; Disease Models, Animal; Endothelium; Injections, | 2011 |
Neuroinflammatory and oxidative stress phenomena in MPS IIIA mouse model: the positive effect of long-term aspirin treatment.
Topics: Animals; Apoptosis; Aspirin; Brain; Disease Models, Animal; Female; Gene Expression Profiling; Gene | 2011 |
Pharmacological action of choline and aspirin coadministration on acute inflammatory pain.
Topics: Acute Disease; Analgesics; Animals; Aspirin; Choline; Disease Models, Animal; Drug Combinations; Fem | 2011 |
Chemoprevention: First line of defence.
Topics: Animals; Aspirin; Celecoxib; Clinical Trials, Phase II as Topic; Colonic Neoplasms; Cyclooxygenase I | 2011 |
Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Base Pair Mismatch; Colorectal Neoplasms, | 2011 |
[Effect of aspirin administration for the treatment of osteoporosis in ovariectomized rat model].
Topics: Animals; Aspirin; Disease Models, Animal; Female; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Daw | 2011 |
Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Collagen; Cycl | 2011 |
Nitroxide derivatives of non-steroidal anti-inflammatory drugs exert anti-inflammatory and superoxide dismutase scavenging properties in A459 cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Carrageenan; Cell Line, Tum | 2012 |
Gastroprotective effect of standardized leaf extract from Argyreia speciosa on experimental gastric ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Butanols; Catalase; Convolvulaceae; Cytoprotection; Disease Mod | 2011 |
Aspirin resistance and platelet turnover: a 25-year old issue.
Topics: Animals; Aspirin; Blood Platelets; Diabetic Angiopathies; Disease Models, Animal; Drug Resistance; H | 2011 |
In vivo and in vitro anti-inflammatory activity of neorogioltriol, a new diterpene extracted from the red algae Laurencia glandulifera.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Cell | 2011 |
The effect of intravesical acetylsalicylic acid instillation on tissue prostaglandin levels after partial bladder outlet obstruction in rabbits.
Topics: Administration, Intravesical; Animals; Aspirin; Carbachol; Collagen; Dinoprost; Dinoprostone; Diseas | 2011 |
Acetylsalicylic acid, but not clopidogrel, inhibits therapeutically induced cerebral arteriogenesis in the hypoperfused rat brain.
Topics: Animals; Aspirin; Brain Ischemia; Cell Line; Cerebral Angiography; Cerebrovascular Circulation; Chem | 2012 |
Chemoprevention of colon cancer in a rat carcinogenesis model using a novel nanotechnology-based combined treatment system.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; As | 2011 |
Antithrombotic activity of Z4A5, a new platelet glycoprotein IIb/IIIa receptor antagonist evaluated in a rabbit arteriovenous shunt thrombosis model.
Topics: Animals; Arteriovenous Shunt, Surgical; Aspirin; Blood Coagulation Tests; Disease Models, Animal; Do | 2011 |
Protective role of cyclooxygenase (COX)-2 in experimental lung injury: evidence of a lipoxin A4-mediated effect.
Topics: Animals; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Iloprost; L | 2012 |
Acetylsalicylic acid inhibits α,β-meATP-induced facilitation of neck muscle nociception in mice--implications for acute treatment of tension-type headache.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase In | 2011 |
Gender-specific antitumor action of aspirin in a murine model of a T-cell lymphoma bearing host.
Topics: Androgens; Animals; Antineoplastic Agents; Aspirin; Cell Cycle; Cell Proliferation; Cell Survival; D | 2012 |
Protective effects of astaxanthin from Paracoccus carotinifaciens on murine gastric ulcer models.
Topics: Acids; Animals; Anti-Ulcer Agents; Aspirin; Biphenyl Compounds; Disease Models, Animal; Ethanol; Fre | 2012 |
Gene therapy with iNOS enhances regional contractility and reduces delayed contrast enhancement in a model of postischemic congestive heart failure.
Topics: Animals; Anticoagulants; Aspirin; Clopidogrel; Contrast Media; Coronary Angiography; Coronary Stenos | 2011 |
Involvement of the L-arginine-nitric oxide pathway in the antinociception caused by fruits of Prosopis strombulifera (Lam.) Benth.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Argentina; Arginine; Aspirin; Cell Line; Disease Mode | 2012 |
Platelets enhance biofilm formation and resistance of endocarditis-inducing streptococci on the injured heart valve.
Topics: Animals; Anti-Bacterial Agents; Anticoagulants; Aspirin; Biofilms; Blood Platelets; Clindamycin; Dis | 2012 |
Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of arbutin.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Arbutin; Aspirin; Cell Line; Cytoprotection; Disease Model | 2012 |
Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice.
Topics: Animals; Aspirin; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Hemostasis; Mice; Mice, | 2012 |
The anti-inflammatory and antinociceptive properties of the chloroform fraction from Phyllanthus niruri plant is mediated via the peripheral nervous system.
Topics: Acetic Acid; Albumins; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Aspirin; Behavio | 2010 |
Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Biomarkers; Blood Platelets; Disease Models, Animal; Dow | 2012 |
Two-wavelength near-infrared fluorescence for the quantitation of drug antiplatelet effects in large animal model systems.
Topics: Analysis of Variance; Animals; Aspirin; Blood Platelets; Cilostazol; Disease Models, Animal; Female; | 2012 |
Anti-inflammatory and analgesic activity of novel oral aspirin-loaded nanoemulsion and nano multiple emulsion formulations generated using ultrasound cavitation.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Behavior, | 2012 |
Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Anti-Infl | 2012 |
Antiulcerogenic activity of hydroalcoholic fruit extract of Pithecellobium dulce in different experimental ulcer models in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Carbohydrate Metabolism; Cell Proliferation; Cold Temperature; | 2012 |
Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: II-the developmental pattern of neurons in relation to oxidative stress and antioxidant defense system.
Topics: Age Factors; alpha-Tocopherol; Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Ascorb | 2012 |
Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia.
Topics: Animals; Animals, Newborn; Apoptosis; Aspirin; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase Inh | 2012 |
Pharmacological evaluation of fruits of Terminalia belerica Roxb. for antiulcer activity.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Biomarkers; Cold Temperature; Disease Models, Animal; Dose-Resp | 2012 |
Antinociceptive effect of the Orbignya speciosa Mart. (Babassu) leaves: evidence for the involvement of apigenin.
Topics: Analgesics; Animals; Apigenin; Arecaceae; Aspirin; Atropine; Brazil; Disease Models, Animal; Dose-Re | 2012 |
Regular ingestion of cinnamomi cortex pulveratus offers gastroprotective activity in mice.
Topics: Acrolein; Animals; Anti-Ulcer Agents; Aspirin; Cinnamomum zeylanicum; Disease Models, Animal; Drugs, | 2013 |
Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury.
Topics: Acute Lung Injury; Adaptor Proteins, Signal Transducing; Airway Resistance; Animals; Anti-Inflammato | 2013 |
Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses.
Topics: Animals; Aspirin; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Cy | 2012 |
Effects of heparin on synaptic activity in the hemorrhagic stroke model in vitro.
Topics: Action Potentials; Animals; Aspirin; Blood Coagulation; Brain; Disease Models, Animal; Fibrinolytic | 2012 |
[Experimental anticoagulant therapy of acute lung injury induced by paraquat].
Topics: Acute Lung Injury; Animals; Anticoagulants; Aspirin; Disease Models, Animal; Drug Therapy, Combinati | 2012 |
Antiinflammatory treatment ameliorates HPA stress axis dysfunction in a mouse model of stress sensitivity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Astrocytes; Corticosterone; Corticotropin | 2012 |
[Effect of cyclooxygenase-2 on bone loss in ovariectomized rats].
Topics: Animals; Aspirin; Bone Density; Bone Resorption; Cyclooxygenase 2; Disease Models, Animal; Female; F | 2012 |
Sulforaphane protects small intestinal mucosa from aspirin/NSAID-induced injury by enhancing host defense systems against oxidative stress and by inhibiting mucosal invasion of anaerobic enterobacteria.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Capillary Permeability; Cel | 2013 |
Caffeic acid phenethyl ester protects kidneys against acetylsalicylic acid toxicity in rats.
Topics: Acute Kidney Injury; Animals; Aspirin; Caffeic Acids; Disease Models, Animal; Dose-Response Relation | 2012 |
Evaluation of the in vivo anti-inflammatory and analgesic activity of a highly water-soluble aspirin conjugate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Disease Models, Animal; Dose | 2013 |
Comparison of the protective effect of dipyridamole and acetylsalicylic acid on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury.
Topics: Animals; Apoptosis; Aspirin; Dipyridamole; Disease Models, Animal; Drug Administration Schedule; In | 2012 |
Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury.
Topics: Acute Lung Injury; Animals; Aspirin; Blood Platelets; Disease Models, Animal; Female; Humans; Lipopo | 2012 |
Evaluation of anti-nociceptive activity of methanolic extract of Tecomaria capensis Thunb. (Bignoniaceae) leaves in rats.
Topics: Acetic Acid; Analgesics; Animals; Aspirin; Bignoniaceae; Disease Models, Animal; Dose-Response Relat | 2012 |
Effect of S-aspirin, a novel hydrogen-sulfide-releasing aspirin (ACS14), on atherosclerosis in apoE-deficient mice.
Topics: Animals; Apolipoproteins E; Aspirin; Atherosclerosis; Brachiocephalic Trunk; Cell Line; Chemotaxis; | 2012 |
Protective effects of Ankaferd blood stopper on aspirin-induced oxidative mucosal damage in a rat model of gastric injury.
Topics: Animals; Aspirin; Disease Models, Animal; Gastric Mucosa; Male; Oxidative Stress; Plant Extracts; Pr | 2014 |
Antithrombotic activities of aqueous extract from Gardenia jasminoides and its main constituent.
Topics: Administration, Oral; Animals; Arteriovenous Shunt, Surgical; Aspirin; Carrageenan; Disease Models, | 2013 |
Oral antigens induce rheumatoid arthritis-like inflammation in a rat model.
Topics: Administration, Oral; Animals; Antigen-Antibody Complex; Antigens; Arthritis, Rheumatoid; Aspirin; C | 2013 |
Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bone Neoplasms; Carcinoma 256, Walker; Di | 2012 |
Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cardiotoxins; Clomipramine; Cyclophosphamide; Disease | 2014 |
The impact of triple anti-platelet therapy for endothelialization and inflammatory response at overlapping bioabsorbable polymer coated drug-eluting stents in a porcine coronary model.
Topics: Absorbable Implants; Animals; Aspirin; Cilostazol; Clopidogrel; Coated Materials, Biocompatible; Cor | 2013 |
Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma.
Topics: Animals; Aspirin; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Dendritic Cells | 2013 |
Preeclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Carrier Proteins | 2013 |
Nitric oxide-releasing aspirin decreases vascular injury by reducing inflammation and promoting apoptosis.
Topics: Animals; Apolipoproteins E; Apoptosis; Aspirin; Cholesterol; Disease Models, Animal; Femoral Artery; | 2002 |
Prevention of hypertension, hyperglycemia and vascular oxidative stress by aspirin treatment in chronically glucose-fed rats.
Topics: Animals; Aorta; Aspirin; Blood Glucose; Blood Pressure; Body Weight; Canada; Cyclooxygenase Inhibito | 2002 |
Acute pulmonary embolism: don't ignore the platelet.
Topics: Acute Disease; Animals; Anticoagulants; Aspirin; Blood Platelets; Clinical Trials as Topic; Clopidog | 2002 |
Oral everolimus inhibits in-stent neointimal growth.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Vessel Prosth | 2002 |
[Effects of combination of octreotide and aspirin on proliferation of human hepatocellular carcinoma].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Carcinoma, Hepatocellular; Cell Di | 2002 |
An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcimycin; Ce | 2002 |
Inhibitory effects of sodium salicylate and acetylsalicylic acid on UVB-induced mouse skin carcinogenesis.
Topics: Administration, Topical; Animals; Anticarcinogenic Agents; Aspirin; Biopsy, Needle; Cell Transformat | 2002 |
[Neuroprotection by aspirin in cerebrovascular pathology].
Topics: Adenosine Triphosphate; Algorithms; Amino Acid Transport System X-AG; Animals; Aspirin; Brain Ischem | 2002 |
Salycylate--induced pancreatic injury in the cat: a preliminary study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Calcium; Cats; Disease Models | 2002 |
The adverse renal effects of prostaglandin-synthesis inhibitors in the newborn rabbit.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Pressure; Cycloox | 2002 |
[Anti-gastric ulcer sesquiterpene lactone glycosides from Crepis napifera].
Topics: Animals; Anti-Ulcer Agents; Aspirin; Crepis; Disease Models, Animal; Female; Gastric Acid; Gastric M | 2002 |
Relationship between apoptosis, angiogenesis and colon-26 tumour growth after oral NSAID-treatment.
Topics: Adenocarcinoma; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; A | 2002 |
Effect of aspirin on late preconditioning against myocardial stunning in conscious rabbits.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Aspi | 2003 |
Late preconditioning against myocardial stunning. Does aspirin close the "second window" of endogenous cardioprotection?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Cyclooxygenase | 2003 |
The effect of ethanol on spermatogenesis and fertility in male Sprague-Dawley rats pretreated with acetylsalicylic acid.
Topics: Alcoholism; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Cyclooxygena | 2002 |
Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhib | 2003 |
Synergistic effect of D-003 and aspirin on experimental thrombosis models.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Aspirin; Death, Sudden; Disease Models, Ani | 2003 |
Glycoprotein IIb/IIIa receptor antagonist (2S)-2-[(2-Naphthyl-sulfonyl)amino]-3-[[2-([4-(4-piperidinyl)-2-[2-(4-piperidinyl)ethyl] butanoyl]amino)acetyl]amino]propanoic acid dihydrochloride (CRL42796), in combination with aspirin and/or enoxaparin, preven
Topics: Animals; Aspirin; Blood Coagulation; Coronary Thrombosis; Dipeptides; Disease Models, Animal; Dogs; | 2003 |
Effect of D-003 on isoproterenol-induced myocardial necrosis in rats.
Topics: Animals; Aspirin; Disease Models, Animal; Fatty Acids; Isoproterenol; Male; Myocardial Infarction; M | 2003 |
NCX4016: a novel antithrombotic agent.
Topics: Animals; Aspirin; Blood Platelets; Disease Models, Animal; Fibrinolytic Agents; Humans; In Vitro Tec | 2003 |
Antiinflammatory and antiulcer activities of Bambusa arundinacea.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Bambusa; Carrageenan; | 2003 |
Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No | 2003 |
Acetylsalicylic acid reduces perfusion deficit in ischemic injured brain in rats.
Topics: Animals; Aspirin; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Fibrinolytic | 2003 |
COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo.
Topics: Animals; Antibodies, Blocking; Aspirin; Benzenesulfonates; Carcinoma, Lewis Lung; Cyclooxygenase Inh | 2003 |
Secretory dysfunction of vascular endothelium limits the effect of angiotensin converting enzyme inhibitor quinapril on aggregation of erythrocytes in experimental hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aspirin; Blood Pressure; Bradykinin; Disease Mode | 2003 |
The protective effects of acetylsalicylic acid on free radical production in cisplatin induced nephrotoxicity: an experimental rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Cisplatin; Disease | 2003 |
Involvement of nitric oxide and prostaglandin pathways in the cardioprotective actions of bradykinin in rats with experimental myocardial infarction.
Topics: Animals; Aspirin; Bradykinin; Disease Models, Animal; Drug Therapy, Combination; Enalapril; Female; | 2004 |
[Protective effects and mechanism of action of aspirin on focal cerebral ischemia-reperfusion in rats].
Topics: Animals; Aspirin; Brain Ischemia; Disease Models, Animal; Epoprostenol; Male; Malondialdehyde; Neuro | 2003 |
The effects of antipyretics on influenza virus encephalitis in mice and chicks.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chickens; Diclofenac; Disease Models, Ani | 2003 |
Evaluation of antiepileptic activity of aspirin in combination with newer antiepileptic lamotrigine in mice.
Topics: Animals; Anticonvulsants; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Co | 2003 |
Hemoglobin-based oxygen carrier provides heterogeneous microvascular oxygenation in heart and gut after hemorrhage in pigs.
Topics: Analysis of Variance; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 2003 |
Antioxidant effect of acetylsalicylic and salicylic acid in rat brain slices subjected to hypoxia.
Topics: Animals; Aspirin; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combina | 2004 |
Administration of a small molecule tissue factor/factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: effects on thrombus formation and bleeding time.
Topics: Animals; Aspirin; Bleeding Time; Body Weight; Disease Models, Animal; Factor VIIa; Macaca fascicular | 2003 |
[Effect of different doses of aspirin on preconditioning against stunning in conscious sheep].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Aspirin; Disease Models, Ani | 2004 |
Antioxidant effects of a single dose of acetylsalicylic acid and salicylic acid in rat brain slices subjected to oxygen-glucose deprivation in relation with its antiplatelet effect.
Topics: Animals; Antioxidants; Aspirin; Cell Hypoxia; Disease Models, Animal; Dose-Response Relationship, Dr | 2004 |
Thrombosis and neointima formation in vein grafts are inhibited by locally applied aspirin through endothelial protection.
Topics: Animals; Arteriosclerosis; Aspirin; Blood Vessel Prosthesis Implantation; Carotid Arteries; Disease | 2004 |
Effects of triflusal on oxidative stress, prostaglandin production and nitric oxide pathway in a model of anoxia-reoxygenation in rat brain slices.
Topics: Analysis of Variance; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Gl | 2004 |
Cerebral perfusion pressure elevation with oxygen-carrying pressor after traumatic brain injury and hypotension in Swine.
Topics: Amyloid beta-Protein Precursor; Animals; Aspirin; Blood Pressure; Blood Volume; Brain Chemistry; Bra | 2004 |
Maternal autoimmune diseases and immunologically induced embryonic and fetoplacental damage.
Topics: Abortion, Habitual; Animals; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome | 2004 |
Inhibition of COX pathway in experimental myocardial infarction.
Topics: Animals; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease | 2004 |
Chemically modified porcine hemoglobins and their biological properties.
Topics: Allosteric Regulation; Animals; Aspirin; Blood Substitutes; Cross-Linking Reagents; Disease Models, | 2004 |
A novel model of occlusive thrombus formation in mice.
Topics: Animals; Arterial Occlusive Diseases; Aspirin; Carotid Artery Diseases; Carotid Artery, Common; Dise | 2004 |
Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia.
Topics: Animals; Apoptosis; Aspirin; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Ma | 2004 |
Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxy | 2004 |
Colorectal cancer and Coxibs.
Topics: 1,2-Dimethylhydrazine; Animals; Aspirin; Carcinogens; Colorectal Neoplasms; Cyclooxygenase Inhibitor | 2004 |
Influence of rofecoxib on experimental colonic carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Aspirin; Carcinogens; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxyg | 2004 |
Evaluation of the tail formalin test in mice as a new model to assess local analgesic effects.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; D | 2004 |
The role of transforming growth factor alpha formulation on aspirin-induced ulcer healing and oxidant stress in the gastric mucosa.
Topics: Analysis of Variance; Animals; Aspirin; Biomarkers; Disease Models, Animal; Gastric Mucosa; Glutathi | 2004 |
The effect of aspirin and high fibre diet on colorectal carcinoma: a comparative experimental study.
Topics: Animals; Aspirin; Chi-Square Distribution; Colorectal Neoplasms; Dietary Fiber; Dimethylhydrazines; | 2004 |
Salicylate inhibition of rat mammary carcinogenesis and angiogenesis in female rat compatible with misoprostol administration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Transformation, Neoplastic; Disease | 2005 |
Nitroaspirin plus clopidogrel versus aspirin plus clopidogrel against platelet thromboembolism and intimal thickening in mice.
Topics: Animals; Aspirin; Blood Coagulation Tests; Clopidogrel; Disease Models, Animal; Drug Therapy, Combin | 2005 |
Antinociceptive effects of choline against acute and inflammatory pain.
Topics: Aconitine; Acute Disease; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Anti-Inflamm | 2005 |
Antiulcerogenic effect of Justicia prostrata Gamble.
Topics: Acanthaceae; Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Dose-Response Relationship | 2005 |
Allophylus serratus: a plant with potential anti-ulcerogenic activity.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Cold Temperature; Disease Models, Animal; | 2005 |
The protective effects of rutaecarpine on gastric mucosa injury in rats.
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Evodia; Female; Gastric Muco | 2005 |
Influence of gastric colonization with Candida albicans on ulcer healing in rats: effect of ranitidine, aspirin and probiotic therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Biopsy; Blood Flow Vel | 2005 |
Histamine-3 receptor antagonists reduce superoxide anion generation and lipid peroxidation in rat brain homogenates.
Topics: Animals; Antioxidants; Aspirin; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; His | 2005 |
Minor inflammation after surgical evacuation compared with fibrinolytic therapy of experimental intracerebral hemorrhages.
Topics: Analysis of Variance; Animals; Aspirin; Blood Transfusion, Autologous; Cerebral Hemorrhage; Confiden | 2005 |
Cyclooxygenase inhibition with acetylsalicylic acid unmasks a role for prostacyclin in erythropoietin-induced hypertension in uremic rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Thoracic; Aspirin; Blood Pressure; Cyclooxygenase Inhi | 2005 |
The antithrombotic effect of melagatran in combination with clopidogrel and/or aspirin (carotid artery primary thrombosis study).
Topics: Animals; Aspirin; Azetidines; Benzylamines; Bleeding Time; Blood Flow Velocity; Blood Pressure; Caro | 2005 |
Aspirin, but not clopidogrel, reduces collateral conductance in a rabbit model of femoral artery occlusion.
Topics: Animals; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Disease Models, Animal; Electrophysiolog | 2005 |
Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Cloning, Molecular; Cyst | 2005 |
Cyclooxygenase-2 inhibition in colon experimental carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Aspirin; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhib | 2005 |
Anticoagulation regimes and their influence on the occlusion rate of aneurysms: an experimental study in rabbits.
Topics: Animals; Anticoagulants; Aspirin; Carotid Arteries; Disease Models, Animal; Embolization, Therapeuti | 2005 |
The cardiovascular pharmacology of COX-2 inhibition.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Blood Pressure; Cardiova | 2005 |
Stabilization of advanced atherosclerosis in low-density lipoprotein receptor-deficient mice by aspirin.
Topics: Animals; Aorta, Thoracic; Aspirin; Atherosclerosis; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dis | 2006 |
Gaultherin, a natural salicylate derivative from Gaultheria yunnanensis: towards a better non-steroidal anti-inflammatory drug.
Topics: Abdominal Pain; Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2006 |
Prevention of carotid artery restenosis after sirolimus-coated stent implantation in pigs.
Topics: Alloys; Angioplasty, Balloon, Coronary; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; A | 2006 |
Attenuation of cardiac hypertrophy in carnitine-deficient juvenile visceral steatosis (JVS) mice achieved by lowering dietary lipid.
Topics: Animals; Aspirin; Carnitine; Diet; Dinoprost; Disease Models, Animal; Dose-Response Relationship, Dr | 2006 |
Potent low dose platelet inhibitory effects of clopidogrel and aspirin on coronary thrombus formation in an animal model of acute unstable angina.
Topics: Acute Disease; Angina, Unstable; Animals; Aspirin; Clopidogrel; Coronary Thrombosis; Disease Models, | 2006 |
Attenuation of neutrophil infiltration and proinflammatory cytokines by Cissus quadrangularis: a possible prevention against gastric ulcerogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cissus; Cytokines; Dis | 2005 |
[The effect of paclitaxel-eluting stents on restenosis].
Topics: Animals; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Restenosis; Coronary | 2006 |
Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Aspirin; Carcinogens; Cell Growth Processes; Cricetinae | 2006 |
Inhibitory effects of cardiotonic pills on platelet function in dogs fed a high-fat diet.
Topics: Animals; Aspirin; Blood Platelets; Calcium; Cardiotonic Agents; Dietary Fats; Disease Models, Animal | 2006 |
Effects of melatonin or acetylsalicylic acid on gastric oxidative stress after bile duct ligation in rats.
Topics: Animals; Aspirin; Bile Ducts; Catalase; Cholestasis; Disease Models, Animal; Glutathione Peroxidase; | 2006 |
Influence of melatonin and acetylsalicylic acid on lipid peroxidation and antioxidant enzyme activities in gastric mucosa.
Topics: Animals; Aspirin; Bile Ducts; Disease Models, Animal; Gastric Mucosa; Lipid Peroxidation; Melatonin; | 2006 |
Role of COX-1 and COX-2 on skin PGs biosynthesis by mechanical scratching in mice.
Topics: Animals; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Epoprost | 2006 |
Antinociceptive effects of synthetic chalcones obtained from xanthoxyline.
Topics: Acetaminophen; Acetic Acid; Acetophenones; Administration, Oral; Analgesics; Animals; Aspirin; Chalc | 2006 |
[Therapeutic effects of low molecular weight heparin and aspirin on acute lung injury in rat].
Topics: Acute Lung Injury; Animals; Aspirin; Disease Models, Animal; Heparin, Low-Molecular-Weight; Intercel | 2006 |
The lipoxygenase-cyclooxygenase inhibitor licofelone prevents thromboxane A2-mediated cardiovascular derangement triggered by the inflammatory peptide fMLP in the rabbit.
Topics: Acetates; Animals; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Elect | 2006 |
Aspirin reduces platelet aggregation during high-energy excimer laser.
Topics: Analysis of Variance; Angioplasty, Balloon, Laser-Assisted; Animals; Aspirin; Biomarkers; Carotid Ar | 2006 |
Prostacyclin therapy increases right ventricular capillarisation in a model for flow-associated pulmonary hypertension.
Topics: Animals; Arachidonic Acid; Aspirin; Blood Pressure; Capillaries; Disease Models, Animal; Echocardiog | 2006 |
Inhibition of the ubiquitin-proteasome system: a new avenue for atherosclerosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aspirin; Atherosclerosis; Cholesterol; Diet | 2006 |
Swine model of carotid artery atherosclerosis: experimental induction by surgical partial ligation and dietary hypercholesterolemia.
Topics: Angiography; Angioplasty, Balloon; Animals; Aspirin; Calcinosis; Carotid Arteries; Carotid Artery In | 2006 |
Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer.
Topics: Animals; Apoptosis; Aspirin; Colorectal Neoplasms; Disease Models, Animal; Dose-Response Relationshi | 2007 |
Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood).
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Ligation; Male; Medici | 2007 |
Effect of clopidogrel on the inflammatory progression of early atherosclerosis in rabbits model.
Topics: Animals; Aspirin; Atherosclerosis; Atorvastatin; Chemokine CCL2; Clopidogrel; Diet, Atherogenic; Dis | 2007 |
Aspirin and ibuprofen enhance pyrazinamide treatment of murine tuberculosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antitubercular Agents; Aspirin; Disease Models, An | 2007 |
Effects of triflusal and aspirin in a rat model of cerebral ischemia.
Topics: Animals; Aspirin; Brain Ischemia; Disease Models, Animal; Drug Therapy, Combination; Male; Rats; Rat | 2007 |
Synthesis and pharmacological evaluation of some 3-(4-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Diclofenac; Disease Models, Ani | 2007 |
Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Disease Models, Animal; Dose-Resp | 2007 |
Modifications produced by indomethacin and L-NAME in the effect of ultralow-dose aspirin on platelet activity in portal hypertension.
Topics: Animals; Aspirin; Blood Coagulation Tests; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug I | 2006 |
Antinociceptive and antiarthritic activity of Cissampelos pareira roots.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Cissampelos; Dexamethasone; Disea | 2007 |
Aspirin before reperfusion blunts the infarct size limiting effect of atorvastatin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Atorvastatin; Cyclooxygenase 1; Cyclooxygenase 2; Cy | 2007 |
Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits.
Topics: Animals; Aspirin; Blood Coagulation; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; | 2007 |
Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat.
Topics: Administration, Oral; Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Ani | 2007 |
High dose aspirin and left ventricular remodeling after myocardial infarction: aspirin and myocardial infarction.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Collagen; Coronary Vessels; Disease Model | 2007 |
Attenuation of gastric mucosal inflammation induced by aspirin through inhibition of selective type III phospshodiesterase in rats.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents; Aspirin; Chemokine CXCL1; Ch | 2007 |
Cannabinoid receptor down-regulation in the ventral cochlear nucleus in a salicylate model of tinnitus.
Topics: Animals; Aspirin; Auditory Pathways; Behavior, Animal; Cell Count; Cochlear Nucleus; Disease Models, | 2007 |
The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Dipyrone; Disease | 2007 |
The thrombolytic effect of aspirin in animal model.
Topics: Adenosine Diphosphate; Adult; Animals; Aspirin; Disease Models, Animal; Female; Fibrinolysis; Humans | 2007 |
Gastroprotective effects of DA-6034, a new flavonoid derivative, in various gastric mucosal damage models.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Centra | 2007 |
Intragastric nitroglycerin at a vasodilatory dose attenuates acidified aspirin-induced gastric mucosal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Flow Velocity; Disease Models, Anim | 2007 |
Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits.
Topics: Adenosine Diphosphate; Analysis of Variance; Animals; Aspirin; Biomarkers; Bleeding Time; Blood Plat | 2007 |
Synthesis and pharmacological investigation of novel 3-(3-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Diclofenac; Disease Models, Ani | 2007 |
Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Carcinogens; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor | 2007 |
dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP.
Topics: Animals; Aspirin; Benzofurans; Brain; Brain Ischemia; Cerebral Arteries; Cerebrovascular Circulation | 2007 |
Effect of combination of endothelin receptor antagonist (TAK-044) and aspirin in middle cerebral artery occlusion model of acute ischemic stroke in rats.
Topics: Animals; Antioxidants; Aspirin; Brain Ischemia; Disease Models, Animal; Drug Therapy, Combination; E | 2007 |
[From willow bark to the coxibs. Development of antiphlogistic analgesics].
Topics: Acetanilides; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Aspirin; Cyc | 2007 |
[Soluble CD40 ligand: a potential marker of cardiovascular risk].
Topics: Abciximab; Acute Coronary Syndrome; Alanine; Angina, Unstable; Animals; Antibodies, Monoclonal; Anti | 2007 |
Hyperbaric oxygen treatment is comparable to acetylsalicylic acid treatment in an animal model of arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Behavior, Animal; Carrageenan; | 2007 |
Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Aorta; Aspirin; Blood Coagulation; Collagen; Disease Mo | 2007 |
A thromboxane A2/prostaglandin H2 receptor antagonist (S18886) shows high antithrombotic efficacy in an experimental model of stent-induced thrombosis.
Topics: Administration, Oral; Animals; Aorta; Aspirin; Bleeding Time; Blood Coagulation; Clopidogrel; Diseas | 2007 |
Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dinopros | 2007 |
Roles of platelet and endothelial cell COX-1 in hypercholesterolemia-induced microvascular dysfunction.
Topics: Animals; Aspirin; Blood Platelets; Bone Marrow Transplantation; Cardiovascular Diseases; Cell Adhesi | 2007 |
The history of aspirin.
Topics: Animals; Aspirin; Coronary Circulation; Coronary Thrombosis; Disease Models, Animal; Fibrinolytic Ag | 2007 |
Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromones; Diclofen | 2007 |
Antinociceptive action of limonexic acid obtained from Raulinoa echinata.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Dru | 2007 |
Renal functional responses to ischaemia-reperfusion injury in normotensive and hypertensive rats following non-selective and selective cyclo-oxygenase inhibition with nitric oxide donation.
Topics: Animals; Aspirin; Blood Pressure; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 In | 2008 |
Coronary artery in-stent stenosis persists despite inhibition of the von Willebrand factor--collagen interaction in baboons.
Topics: Angioplasty, Balloon, Coronary; Animals; Antibodies, Monoclonal; Aspirin; Clopidogrel; Collagen; Cor | 2007 |
The effect of postoperative aspirin on random pattern flaps in rats.
Topics: Animals; Aspirin; Disease Models, Animal; Follow-Up Studies; Graft Survival; Male; Platelet Aggregat | 2007 |
Iliac venous stenting: antithrombotic efficacy of PD0348292, an oral direct Factor Xa inhibitor, compared with antiplatelet agents in pigs.
Topics: Administration, Oral; Angioplasty; Animals; Antithrombin III; Aspirin; Clopidogrel; Constriction, Pa | 2008 |
Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Disease Models, An | 2007 |
Neuroprotection and glutamate attenuation by acetylsalicylic acid in temporary but not in permanent cerebral ischemia.
Topics: Analysis of Variance; Animals; Aspirin; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; | 2008 |
Effect of chronic treatment with acetylsalicylic acid and clopidogrel on atheroprogression and atherothrombosis in ApoE-deficient mice in vivo.
Topics: Animals; Aorta; Apolipoproteins E; Aspirin; Atherosclerosis; Blood Platelets; Carotid Arteries; Chol | 2008 |
The flavonoid luteolin inhibits niacin-induced flush.
Topics: Animals; Aspirin; Body Temperature; Disease Models, Animal; Flushing; Hypolipidemic Agents; Luteolin | 2008 |
Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse.
Topics: Adenosine Diphosphate; Anesthesia; Animals; Aspirin; Blood Platelets; Collagen; Disease Models, Anim | 2008 |
Interaction of inflammation, thrombosis, aspirin and enoxaparin in CNS experimental antiphospholipid syndrome.
Topics: Alprostadil; Analysis of Variance; Animals; Antiphospholipid Syndrome; Aspirin; Behavior, Animal; be | 2008 |
A pioneer study on the anti-ulcer activities of copper nicotinate complex [CuCl (HNA)2] in experimental gastric ulcer induced by aspirin-pylorus [corrected] ligation model (Shay model).
Topics: Animals; Anti-Ulcer Agents; Apoptosis; Aspirin; Disease Models, Animal; DNA Fragmentation; Gastric J | 2009 |
Evaluation of the changes in hemostatic parameters induced by etoricoxib in rat model.
Topics: Animals; Aspirin; Blood Coagulation Tests; Cyclooxygenase Inhibitors; Disease Models, Animal; Etoric | 2008 |
Comparison of PD0348292, a selective factor Xa inhibitor, to antiplatelet agents for the inhibition of arterial thrombosis.
Topics: Administration, Oral; Animals; Aspirin; Bleeding Time; Blood Coagulation; Carotid Artery Injuries; C | 2008 |
[Antiatherosclerotic mechanism of aspirin: experiment with rabbits].
Topics: Animals; Aspirin; Atherosclerosis; C-Reactive Protein; Cholesterol, Dietary; Cyclooxygenase 2; Cyclo | 2007 |
Comparison of anticoagulant effects on vein grafts between human TFPI gene transfection and aspirin oral administration.
Topics: Administration, Oral; Animals; Anticoagulants; Aspirin; Coronary Artery Bypass; Disease Models, Anim | 2008 |
Antinociceptive activity of the methanolic extract of Kaempferia galanga Linn. in experimental animals.
Topics: Analgesics; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Medici | 2008 |
Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2.
Topics: Animals; Aspirin; Base Sequence; Blood Vessels; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase I | 2008 |
Comparison of the action of antiphlogistics, anti-anaphylactics and antihistaminics in the carrageenin- & immunologically-induced inflammation model in the rat and in passive cutaneous anaphylaxis.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Disease Models, Animal; Edema; Female; Hist | 1982 |
Laser-induced thrombi in rat mesenteric vessels and antithrombotic drugs.
Topics: Animals; Aspirin; Blood Platelets; Dipyridamole; Disease Models, Animal; Fibrinolytic Agents; Hepari | 1983 |
Treatment of canine spontaneous diabetes mellitus with aspirin.
Topics: Animals; Aspirin; Cyclic AMP; Cyclic GMP; Diabetes Mellitus; Diabetic Retinopathy; Disease Models, A | 1980 |
Antithrombotic activity and the mechanism of action of trapidil (Rocornal).
Topics: Adenosine Triphosphate; Animals; Aspirin; Blood Coagulation; Blood Platelets; Dipyridamole; Disease | 1982 |
Aspirin-induced damage in the dog Heidenhain pouch and cytoprotection with 16,16-dimethyl PGE2.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Aspirin; Disease Models, Animal; Dogs; Female; Gastric Muco | 1984 |
Comparison of piroxicam, meclofenamate, ibuprofen, aspirin, and prostacyclin efficacy in a chronic model of cerebral vasospasm.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Behavior, Animal; Cerebral Angiography; Disease Models, | 1983 |
The influence of dose, time of administration, body temperature and salicylate kinetics on the antithrombotic action of acetylsalicylic acid in male rats.
Topics: Animals; Aspirin; Body Temperature; Cyclooxygenase Inhibitors; Disease Models, Animal; Kinetics; Mal | 1983 |
Effects of protein deficiency on the metabolism of arachidonic acid by rat pleural polymorphonuclear leukocytes.
Topics: Animals; Arachidonic Acids; Aspirin; Carrageenan; Disease Models, Animal; Kidney Medulla; Lipoxygena | 1983 |
[Efficacy of different therapeutic principles in experimental retinal vessel occlusions].
Topics: Animals; Aspirin; Disease Models, Animal; Epoprostenol; Laser Therapy; Nitroglycerin; Rabbits; Retin | 1983 |
Macrophage-dependent arachidonate metabolism in hydronephrosis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Bradykinin; Chromatography, Thin Layer; Dinop | 1984 |
Altered auditory brainstem evoked responses in the ferret model for Reye's syndrome.
Topics: Ammonia; Animals; Aspirin; Audiometry; Audiometry, Evoked Response; Brain Stem; Disease Models, Anim | 1984 |
[Formalin-induced minor tremor response as an indicator of pain].
Topics: Aminopyrine; Analgesics; Animals; Aspirin; Carrageenan; Disease Models, Animal; Dose-Response Relati | 1984 |
Aspirin in experimental cataractogenesis.
Topics: Animals; Aspirin; Cataract; Disease Models, Animal; Female; Galactose; Male; Naphthalenes; Rabbits; | 1984 |
Antiulcer effects of trimipramine using various laboratory models.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Dibenzazepines; Disease Models, Animal; Humans; Mal | 1984 |
Development of encephalopathic features similar to Reye syndrome in rabbits.
Topics: Acetaminophen; Animals; Aspirin; Disease Models, Animal; Encephalitis; Fatty Acids, Nonesterified; F | 1984 |
Free fatty acids in an animal model of Reye's syndrome.
Topics: Ammonia; Animals; Aspirin; Carnivora; Diet; Disease Models, Animal; Fatty Acids, Nonesterified; Ferr | 1983 |
Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate.
Topics: Adenocarcinoma; Animals; Aspirin; Cocarcinogenesis; Diet; Disease Models, Animal; Leiomyosarcoma; Ma | 1984 |
The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats.
Topics: Animals; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Aspirin; Coronary Vessels; Disease Models, | 1984 |
[Experimental models for peptic ulcer].
Topics: Animals; Aspirin; Disease Models, Animal; Dogs; Histamine; Immersion; Indomethacin; Peptic Ulcer; Ra | 1984 |
Bleeding time in rats: a comparison of different experimental conditions.
Topics: Anesthetics; Animals; Aspirin; Bleeding Time; Blood Coagulation; Blood Platelet Disorders; Dipyridam | 1982 |
Canine lymphosarcoma: a model for study of the hypercalcemia of cancer.
Topics: Animals; Antineoplastic Agents; Aspirin; Bone Resorption; Calcium; Disease Models, Animal; Dog Disea | 1980 |
A new reproducible experimental model of analgesic nephropathy.
Topics: Acetaminophen; Analgesics; Animals; Antipyrine; Aspirin; Disease Models, Animal; Female; Kidney; Kid | 1983 |
Mouse antithrombotic assay: a simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by ethyl alcohol.
Topics: Adenosine Triphosphate; Animals; Aspirin; Collagen; Disease Models, Animal; Drug Synergism; Epinephr | 1983 |
Effects of ticlopidine and aspirin on endotoxin-induced disseminated intravascular coagulation in rats.
Topics: Animals; Aspirin; Disease Models, Animal; Disseminated Intravascular Coagulation; Endotoxins; Female | 1983 |
Assessment of nonsteroidal anti-inflammatory drug combinations by the polyurethane sponge implantation model in the rat.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug | 1983 |
Interactions of aspirin and other potential etiologic factors in an animal model of Reye syndrome.
Topics: Ammonia; Animals; Arginine; Aspartate Aminotransferases; Aspirin; Diet; Disease Models, Animal; Ferr | 1982 |
[Comparison of the effect of 3-amino-4-mercapto-6-methylpyridazine with various antiphlogistic agents in rat models of inflammation].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Di | 1982 |
"Aspirinated" platelets are hemostatic in thrombocytopenic rats with "nonaspirinated" vessel walls--evidence from an exchange transfusion model.
Topics: Animals; Arachidonic Acids; Aspirin; Bleeding Time; Blood Vessels; Disease Models, Animal; Epoproste | 1980 |
Retrolental fibroplasia: evidence for a role of the prostaglandin cascade in the pathogenesis of oxygen-induced retinopathy in the newborn beagle.
Topics: Animals; Aspirin; Disease Models, Animal; Dogs; Epoprostenol; Oxygen Inhalation Therapy; Retinal Ves | 1981 |
Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation?
Topics: Animals; Aspirin; Constriction, Pathologic; Coronary Angiography; Coronary Circulation; Coronary Dis | 1982 |
Role of gastric mucosal folds in formation of focal ulcers in the rat.
Topics: Action Potentials; Animals; Aspirin; Disease Models, Animal; Gastric Mucosa; Ischemia; Permeability; | 1982 |
[Transfer of data to man and pathological models].
Topics: Animals; Aspirin; Cattle; Diarrhea; Disease Models, Animal; Humans; Kinetics; Sulfamethazine; Trimet | 1982 |
Spontaneous activity in the trachea of dogs treated with indomethacin: an experimental model for aspirin-related asthma.
Topics: Animals; Aspirin; Asthma; Atropine; Disease Models, Animal; Dogs; Female; Indomethacin; Male; Muscle | 1981 |
The "Internal Leak" as a possible cause in the pathogenesis of peptic ulcer.
Topics: Acridine Orange; Animals; Aspirin; Cats; Disease Models, Animal; Gastric Mucosa; Peptic Ulcer | 1981 |
Testing and treatment of arterial graft thrombosis.
Topics: Animals; Arteries; Aspirin; Blood Vessel Prosthesis; Constriction, Pathologic; Disease Models, Anima | 1981 |
Endotoxic shock in the primate: effects of aspirin and dipyridamole administration.
Topics: Animals; Aspirin; Blood Coagulation; Blood Pressure; Depression, Chemical; Dipyridamole; Disease Mod | 1981 |
Study of antiulcer activity of aqueous extract of leaves of Pyrenacantha staudtii (family Icacinaceae) using various models of experimental gastric ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Female; Indomethacin; Male; Nigeria; Pl | 1981 |
An hypothesis concerning the protective action of paracetamol against the erosive activity of acetylsalicylic acid in the rat stomach.
Topics: Acetaminophen; Animals; Aspirin; Disease Models, Animal; Gastric Mucosa; Male; Peptic Ulcer; Rats | 1980 |
Changes of prostaglandin and thromboxane levels in pleural fluid of rat carrageenin-induced pleurisy.
Topics: Animals; Aspirin; Butylated Hydroxytoluene; Carrageenan; Disease Models, Animal; Imidazoles; Inflamm | 1980 |
SEM of the ciliary processes after paracentesis.
Topics: Animals; Aspirin; Ciliary Body; Disease Models, Animal; Eye Injuries; Female; Functional Laterality; | 1980 |
Reye syndrome model in rats: protection against liver abnormalities by L-carnitine and acetyl-L-carnitine.
Topics: Acetylcarnitine; Acyl Coenzyme A; Animals; Aspirin; Carnitine; Coenzyme A; Disease Models, Animal; K | 1995 |
Anti-ulcerogenic evaluation of the methanolic extracts of some indigenous medicinal plants of Pakistan in aspirin-ulcerated rats.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Drug Evaluation, | 1995 |
Effect of multiple-dose activated charcoal on the clearance of high-dose intravenous aspirin in a porcine model.
Topics: Animals; Antidotes; Aspirin; Charcoal; Cross-Over Studies; Disease Models, Animal; Drug Evaluation, | 1995 |
Experimental thrombosis model induced by free radicals. Application to aspirin and other different substances.
Topics: Allopurinol; Animals; Antioxidants; Arterioles; Ascorbic Acid; Aspirin; Blood Coagulation; Blood Pla | 1995 |
Superior activity of a thromboxane receptor antagonist as compared with aspirin in rat models of arterial and venous thrombosis.
Topics: Animals; Aspirin; Bleeding Time; Bridged Bicyclo Compounds, Heterocyclic; Carotid Artery Thrombosis; | 1993 |
Sodium nitroprusside, an endothelium-derived relaxing factor congener, increases platelet cyclic GMP levels and inhibits epinephrine-exacerbated in vivo platelet thrombus formation in stenosed canine coronary arteries.
Topics: Animals; Aspirin; Blood Platelets; Blood Pressure; Coronary Circulation; Coronary Thrombosis; Cyclic | 1993 |
Thromboxane receptor antagonist BMS-180291, but not aspirin, reduces the severity of pacing-induced ischemia in dogs.
Topics: Angina Pectoris; Animals; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Cardiac Pacing, Artifici | 1994 |
A new animal model of coronary thrombosis and effects of antithrombotic agents.
Topics: Animals; Aspirin; Coronary Thrombosis; Disease Models, Animal; Drug Therapy, Combination; Fibrinolyt | 1995 |
Inhibition of restenosis by beraprost sodium (a prostaglandin I2 analogue) in the atherosclerotic rabbit artery after angioplasty.
Topics: Administration, Oral; Angioplasty, Balloon; Animals; Arteriosclerosis; Aspirin; Cholesterol, Dietary | 1995 |
Effect of acute administration of fish oil (omega-3 marine triglyceride) on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Fish Oils; Gastric Aci | 1995 |
Diaspirin crosslinked hemoglobin (DCLHb): absence of increased free radical generation following administration in a rabbit model of renal ischemia and reperfusion.
Topics: Animals; Aspirin; Cyclic N-Oxides; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Fre | 1995 |
Aspirin and anticonvulsant interaction.
Topics: Animals; Aspirin; Carbamazepine; Disease Models, Animal; Drug Synergism; Electroshock; Female; Male; | 1995 |
Effect of low dose aspirin on cardiorenal function and acute hemodynamic response to enalaprilat in a canine model of severe heart failure.
Topics: Aldosterone; Animals; Aspirin; Atrial Natriuretic Factor; Disease Models, Animal; Dogs; Drug Adminis | 1995 |
Effect of inhibitors of factor Xa or platelet adhesion, heparin, and aspirin on platelet deposition in an atherosclerotic rabbit model of angioplasty injury.
Topics: Angioplasty, Balloon, Coronary; Animals; Arteriosclerosis; Arthropod Proteins; Aspirin; Blood Platel | 1995 |
Beneficial effect of nitroglycerin on arterial rethrombosis after thrombolysis. Results from a rabbit thrombosis model.
Topics: Animals; Aspirin; Blood Flow Velocity; Blood Pressure; Disease Models, Animal; Drug Therapy, Combina | 1995 |
Inhibitory effects of aspirin on coronary hyperreactivity to autacoids after arterial balloon injury in miniature pigs.
Topics: Angiography; Angioplasty, Balloon, Coronary; Animals; Aspirin; Autacoids; Blood Pressure; Constricti | 1995 |
Intravenous aspirin causes a paradoxical attenuation of cerebrovascular thrombolysis.
Topics: Animals; Aspirin; Bleeding Time; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, A | 1995 |
An experimental model of osteoarthritis in rabbit.
Topics: Animals; Aspirin; Disease Models, Animal; Indomethacin; Male; Osteoarthritis; Rabbits | 1994 |
Inhibition of platelet deposition by combined hirulog and aspirin in a rat carotid endarterectomy model.
Topics: Animals; Aspirin; Blood Platelets; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Th | 1995 |
The skin bleeding time test as a predictor of brain bleeding time in a rat model.
Topics: Animals; Aspirin; Bleeding Time; Blood Platelet Disorders; Brain; Disease Models, Animal; Predictive | 1994 |
Adenosine-mediated inhibition of platelet aggregation by acadesine. A novel antithrombotic mechanism in vitro and in vivo.
Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Aspirin; Bloo | 1994 |
Role of aspirin in modulating myocardial ischemic reperfusion injury.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Aspirin; Blood Pressure; Creatinine; Disease | 1994 |
Antithrombotic effects of KW-3635, a thromboxane A2-receptor antagonist, in guinea pigs.
Topics: Animals; Arterial Occlusive Diseases; Aspirin; Benzimidazoles; Benzoxepins; Blood Coagulation; Blood | 1994 |
Aspirin reduces the incidence of colonic carcinoma in the dimethylhydrazine rat animal model.
Topics: Animals; Aspirin; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Dose-Response Relat | 1994 |
[Stimulation of peritoneal macrophage activity in rats with experimental peritonitis by transfusion of ultraviolet-irradiated blood].
Topics: Acute Disease; Animals; Aspirin; Blood; Blood Transfusion; Disease Models, Animal; Lipid Peroxidatio | 1994 |
Pharmacological characterization of FCE 27262, a combined thromboxane synthase inhibitor and PGH2/TXA2 receptor antagonist.
Topics: Animals; Aorta; Aspirin; Blood Platelets; Carbazoles; Coronary Thrombosis; Disease Models, Animal; D | 1993 |
Clopidogrel is more effective than aspirin in preventing coronary artery reocclusion after thrombolysis.
Topics: Animals; Aspirin; Blood Coagulation; Clopidogrel; Coronary Thrombosis; Disease Models, Animal; Dogs; | 1993 |
Asynchrony in circadian rhythms of gastric function in the rat. A model for gastric mucosal injury.
Topics: Animals; Aspirin; Bicarbonates; Cimetidine; Circadian Rhythm; Disease Models, Animal; Epoprostenol; | 1994 |
A new animal model of venous thrombosis in rats with low flow conditions in the venous blood stream.
Topics: Animals; Anticoagulants; Aspirin; Blood Flow Velocity; Constriction; Disease Models, Animal; Epopros | 1994 |
The efficacy of diaspirin crosslinked hemoglobin solution resuscitation in a model of uncontrolled hemorrhage.
Topics: Animals; Aspirin; Blood Pressure; Disease Models, Animal; Hemodynamics; Hemoglobins; Hemorrhage; Iso | 1994 |
Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics.
Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Aspirin; Clonidine; Diabetes Mellitus, Experi | 1994 |
Inhibitory effect of KW-3635, a new thromboxane A2-receptor antagonist, on arterial thrombosis in guinea pigs.
Topics: Animals; Arachidonic Acid; Aspirin; Benzimidazoles; Benzoxepins; Collagen; Disease Models, Animal; F | 1993 |
The role of various antithrombotic agents in microvascular surgery.
Topics: Administration, Oral; Anastomosis, Surgical; Animals; Aspirin; Bleeding Time; Disease Models, Animal | 1994 |
The significance of experimental models of systemic lupus erythematosus and antiphospholipid syndrome induced by idiotypic manipulation.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Anticardiolipin; Antibodies, Antinuclear; Antiphosp | 1994 |
[Acidified aspirin-induced gastric lesion in rats with hepatic cirrhosis produced by N-nitrosodiethylamine or carbon tetrachloride. Effect of aldioxa on gastric lesions].
Topics: Allantoin; Aluminum Hydroxide; Animals; Antacids; Aspirin; Carbon Tetrachloride; Diethylnitrosamine; | 1994 |
Experimental carotid thrombosis in the guinea pig.
Topics: Acetates; Animals; Aspirin; Biomechanical Phenomena; Blood Flow Velocity; Blood Pressure; Carotid Ar | 1994 |
Correlation between bleeding time and antithrombotic effect of platelet-suppressive agents in rat experimental model.
Topics: Animals; Aspirin; Bleeding Time; Carotid Artery Thrombosis; Disease Models, Animal; Male; Platelet A | 1994 |
Effects of ketoprofen on respiratory and circulatory changes in endotoxic shock.
Topics: Animals; Aspirin; Blood Circulation; Carbon Dioxide; Disease Models, Animal; Drug Evaluation, Precli | 1993 |
Combined effect of the 5-HT2 receptor antagonist DV-7028 and aspirin or heparin on coronary cyclic flow reductions in dogs.
Topics: Animals; Aspirin; Blood Pressure; Coronary Circulation; Coronary Disease; Disease Models, Animal; Do | 1993 |
Experimental thrombosis on a collagen coated arterioarterial shunt in rats: a pharmacological model to study antithrombotic agents inhibiting thrombin formation and platelet deposition.
Topics: Animals; Anticoagulants; Arterio-Arterial Fistula; Aspirin; Carotid Artery Thrombosis; Clopidogrel; | 1993 |
Effect of Y-20811, a thromboxane synthetase inhibitor, on photochemically induced cerebral embolism in rabbits.
Topics: Animals; Aspirin; Carotid Artery Thrombosis; Carotid Stenosis; Cerebral Infarction; Disease Models, | 1993 |
Fibroblast growth factor in gastroprotection and ulcer healing: interaction with sucralfate.
Topics: Acetates; Acetic Acid; Acute Disease; Animals; Aspirin; Disease Models, Animal; Dose-Response Relati | 1993 |
Combined use of aspirin and heparin inhibits in vivo acute carotid thrombosis.
Topics: Animals; Aspirin; Carotid Arteries; Carotid Artery Thrombosis; Disease Models, Animal; Drug Combinat | 1993 |
Use of base deficit to compare resuscitation with lactated Ringer's solution, Haemaccel, whole blood, and diaspirin cross-linked hemoglobin following hemorrhage in rats.
Topics: Acid-Base Equilibrium; Animals; Aspirin; Disease Models, Animal; Hemoglobins; Isotonic Solutions; Ma | 1993 |
Effects of aspirin in arterial thrombosis: why don't animals behave the way humans do?
Topics: Animals; Aspirin; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Humans; Platelet A | 1993 |
Effects of aspirin on embolization in an arterial model of laser-induced thrombus formation.
Topics: Animals; Arterioles; Aspirin; Disease Models, Animal; Embolism; Lasers; Lysine; Male; Platelet Aggre | 1993 |
Failure of calcium channel blockade to reduce platelet-mediated cyclic flow variations in dogs with coronary stenosis and endothelial injury.
Topics: Animals; Aspirin; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; Disea | 1995 |
Studies on antiulcer agents. IV. Antiulcer effects of 2-benzylthio5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Duodenal Ulcer; Epirizole; | 1995 |
A ferret model of electrical-induction of arterial thrombosis that is sensitive to aspirin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Blood Platelet | 1996 |
In vivo evaluation of antiplatelet agents in gerbil model of carotid artery thrombosis.
Topics: Animals; Aspirin; Carotid Artery Diseases; Carotid Artery Injuries; Carotid Artery, Common; Cerebrov | 1996 |
A novel 5-lipoxygenase inhibitor prevents gallstone formation in a lithogenic prairie dog model.
Topics: Animals; Aspirin; Cholelithiasis; Cholesterol; Cyclooxygenase Inhibitors; Disease Models, Animal; En | 1996 |
Zwitterionic phospholipids enhance aspirin's therapeutic activity, as demonstrated in rodent model systems.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Analysis of Variance; Animals; Aspirin; Body Temperature; Diseas | 1996 |
Aspirin renders the oesophageal mucosa more permeable to acid and pepsin.
Topics: Acids; Animals; Aspirin; Cell Division; Dinoprostone; Disease Models, Animal; Esophagitis; Esophagus | 1995 |
Aspirin increases tissue oedema after skeletal muscle ischaemia and reperfusion.
Topics: Administration, Oral; Animals; Aspirin; Cell Movement; Disease Models, Animal; Edema; Hindlimb; Infu | 1996 |
[A rat middle cerebral artery thrombosis model for evaluation of thrombolytic and antithrombotic agents].
Topics: Animals; Aspirin; Chlorides; Disease Models, Animal; Ferric Compounds; Fibrinolytic Agents; Intracra | 1995 |
Effect of cyclo-oxygenase inhibitors and modulators of cyclic AMP formation on lipopolysaccharide-induced neutrophil infiltration in mouse lung.
Topics: Administration, Inhalation; Animals; Antifungal Agents; Aspirin; Bronchoalveolar Lavage Fluid; Cycli | 1996 |
Diaspirin crosslinked hemoglobin (DCLHb): more effective than lactated Ringer's solution in restoring central venous oxygen saturation after hemorrhagic shock in rats.
Topics: Animals; Aspirin; Disease Models, Animal; Hemoglobins; Isotonic Solutions; Jugular Veins; Male; Oxyg | 1996 |
Antithrombotic effects of aspirin and LMWH in a laser-induced model of arterials and venous thrombosis.
Topics: Administration, Cutaneous; Animals; Aspirin; Disease Models, Animal; Heparin, Low-Molecular-Weight; | 1996 |
Antithrombotic activity of inogatran, a new low-molecular-weight inhibitor of thrombin, in a closed-chest porcine model of coronary artery thrombosis.
Topics: Animals; Aspirin; Coronary Thrombosis; Disease Models, Animal; Female; Glycine; Heparin; Male; Piper | 1996 |
Effects of inogatran, a new low-molecular-weight thrombin inhibitor, in rat models of venous and arterial thrombosis, thrombolysis and bleeding time.
Topics: Animals; Antithrombins; Arginine; Aspirin; Bleeding Time; Disease Models, Animal; Fibrinolytic Agent | 1996 |
Inhibitory effect of a novel orally active GP IIb/IIIa inhibitor, SC-54684A on intimal thickening in the guinea pig femoral artery.
Topics: Angioplasty, Balloon, Coronary; Animals; Aspirin; Benzamidines; Cell Movement; Cells, Cultured; Coro | 1996 |
A technique to investigate microvascular mural thrombus formation in arteries and veins: II. Effects of aspirin, heparin, r-hirudin, and G-4120.
Topics: Animals; Anticoagulants; Aspirin; Carotid Artery Thrombosis; Cricetinae; Disease Models, Animal; Dos | 1997 |
Resuscitation of pulmonary contusion: effects of a red cell substitute.
Topics: Animals; Aspirin; Blood Substitutes; Contusions; Disease Models, Animal; Drug Evaluation, Preclinica | 1997 |
Combination of aspirin and metoclopramide produces a synergistic antithrombotic effect in a canine model of coronary artery thrombosis.
Topics: Animals; Aspirin; Blood Pressure; Coronary Circulation; Coronary Disease; Coronary Thrombosis; Disea | 1997 |
The effect of acetaminophen on tooth movement in rabbits.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1997 |
Pulmonary hypertension and systemic vasoconstriction may offset the benefits of acellular hemoglobin blood substitutes.
Topics: Albumins; Animals; Aspirin; Cerebrovascular Circulation; Constriction, Pathologic; Disease Models, A | 1997 |
Effect of small-volume resuscitation on intracranial pressure and related cerebral variables.
Topics: Animals; Aspirin; Brain Injuries; Cerebrovascular Circulation; Dextrans; Disease Models, Animal; Dru | 1997 |
Effects of peroxisome proliferators and/or hypothyroidism on xenobiotic-metabolizing enzymes in rat testis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arylsulfotransferase; Aspiri | 1997 |
Lack of any additional benefit in combining aspirin with iloprost in a canine model of myocardial reperfusion injury.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Aspirin; Blood Pressure; Cyclooxygenase Inhib | 1997 |
Frequency selectivity on aspirin-induced hearing loss in rats with auditory stimulus-induced conditioned suppression.
Topics: Acoustic Stimulation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Auditory Threshold; | 1997 |
Discrimination of site-specific alterations in gastrointestinal permeability in the rat.
Topics: Animals; Aspirin; Biological Transport; Cyclooxygenase Inhibitors; Digestive System; Disease Models, | 1998 |
Discrimination of site-specific alterations in gastrointestinal permeability in the rat.
Topics: Animals; Aspirin; Biological Transport; Cyclooxygenase Inhibitors; Digestive System; Disease Models, | 1998 |
Discrimination of site-specific alterations in gastrointestinal permeability in the rat.
Topics: Animals; Aspirin; Biological Transport; Cyclooxygenase Inhibitors; Digestive System; Disease Models, | 1998 |
Discrimination of site-specific alterations in gastrointestinal permeability in the rat.
Topics: Animals; Aspirin; Biological Transport; Cyclooxygenase Inhibitors; Digestive System; Disease Models, | 1998 |
Involvement of fibrinogen in protamine-induced pulmonary hypertension.
Topics: Animals; Aspirin; Blood; Blood Pressure; Cattle; Cyclooxygenase Inhibitors; Disease Models, Animal; | 1997 |
Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation.
Topics: Air; Air Sacs; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Croton Oil; Cyclooxygenase | 1998 |
Cyclooxygenase-independent chemoprevention with an aspirin derivative in a rat model of colonic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Aspirin; Azoxymethane; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase | 1998 |
Intravenous administration of the glycoprotein IIb-IIIa receptor antagonist 7E3 induces reperfusion of an acute thrombotic occlusion of the canine coronary artery.
Topics: Abciximab; Acute Disease; Animals; Antibodies, Monoclonal; Anticoagulants; Aspirin; Blood Coagulatio | 1998 |
Aspirin prevents tumors in a murine model of familial adenomatous polyposis.
Topics: Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; be | 1998 |
Enhancement of aspirin-induced gastric damage by cholestasis in rats.
Topics: Animals; Aspirin; Bile Ducts; Cholestasis; Disease Models, Animal; Gastric Mucosa; Irritants; Laparo | 1998 |
Effect of a novel tetrapeptide derivative in a model of isoproterenol induced myocardial necrosis.
Topics: Adrenergic beta-Agonists; Animals; Aspirin; Body Weight; Creatine Kinase; Disease Models, Animal; Fe | 1998 |
Effects of clopidogrel, aspirin and combined therapy in a porcine ex vivo model of high-shear induced stent thrombosis.
Topics: Animals; Arteriovenous Shunt, Surgical; Aspirin; Bleeding Time; Blood Platelets; Clopidogrel; Corona | 1998 |
Low-volume resuscitation with a hemoglobin-based oxygen carrier after hemorrhage improves gut microvascular oxygenation in swine.
Topics: Animals; Aspirin; Blood Substitutes; Disease Models, Animal; Female; Hemodynamics; Hemoglobins; Ileu | 1998 |
Pathogenesis of acute radiation effects in the urinary bladder. Experimental results.
Topics: Animals; Aspirin; Disease Models, Animal; Mice; Radiation Injuries, Experimental; Radiotherapy; Time | 1998 |
Involvement of thromboxane A2 and prostacyclin in the early pulmonary hypertension after porcine meconium aspiration.
Topics: Adaptation, Physiological; Animals; Animals, Newborn; Aspirin; Cyclooxygenase Inhibitors; Disease Mo | 1998 |
The effects of diaspirin cross-linked hemoglobin on hemodynamics, metabolic acidosis, and survival in burned rats.
Topics: Acidosis; Animals; Aspirin; Burns; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therap | 1999 |
The differential effects of aspirin on platelets, leucocytes and vascular endothelium in an in vivo model of thrombus formation.
Topics: Animals; Aspirin; Blood Coagulation; Blood Platelets; Disease Models, Animal; Dose-Response Relation | 1999 |
Arachidonic acid-induced hind limb gangrene: a new experimental rat model of peripheral vascular disease.
Topics: Animals; Arachidonic Acid; Aspirin; Disease Models, Animal; Disease Progression; Drug Evaluation, Pr | 1999 |
[Aspirin and the prevention of pre-eclampsia: focus in 1999].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Controlled Clinical Trials as Topic; Dise | 1999 |
Subarachnoid hemorrhage in rats: effect of singular or sustained hemodilution with alpha-alpha diaspirin crosslinked hemoglobin on cerebral hypoperfusion.
Topics: Animals; Aspirin; Blood Flow Velocity; Cerebrovascular Circulation; Disease Models, Animal; Drug Eva | 1999 |
Oxidative damage in fetal rat brain induced by ischemia and subsequent reperfusion. Relation to arachidonic acid peroxidation.
Topics: Animals; Arachidonic Acid; Aspirin; Brain; Cyclooxygenase Inhibitors; Disease Models, Animal; Female | 1999 |
Antithrombotic efficacy of a novel murine antihuman factor IX antibody in rats.
Topics: Anesthesia; Animals; Antibodies, Monoclonal; Anticoagulants; Arterial Occlusive Diseases; Aspirin; B | 1999 |
An alternative model of carotid artery thrombosis in rats.
Topics: Animals; Aspirin; Blood Cell Count; Carotid Artery Thrombosis; Catheterization; Disease Models, Anim | 1999 |
Formation of endogenous "antiinflammatory" lipid mediators by transcellular biosynthesis. Lipoxins and aspirin-triggered lipoxins inhibit neutrophil recruitment and vascular permeability.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Aspirin; Biopsy, Needle; Capill | 2000 |
Antiplatelet and antithrombotic effects of orbofiban, a new orally active GPIIb/IIIa antagonist, in guinea pigs.
Topics: Adenosine Diphosphate; Administration, Oral; Alanine; Animals; Arteriovenous Shunt, Surgical; Aspiri | 2000 |
Isolation of the antiulcer compound in essential oil from the leaves of Cryptomeria japonica.
Topics: Acetaldehyde; Animals; Anti-Ulcer Agents; Aspirin; Cycadopsida; Disease Models, Animal; Gastric Juic | 2000 |
Histopathologic analysis of in-stent neointimal regression in a porcine coronary model.
Topics: Animals; Aspirin; Coronary Vessels; Disease Models, Animal; Platelet Aggregation Inhibitors; Prospec | 2000 |
Prevention of pulmonary thromboembolism by NCX 4016, a nitric oxide-releasing aspirin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Disease Models | 2000 |
Endogenous tissue factor pathway inhibitor modulates thrombus formation in an in vivo model of rabbit carotid artery stenosis and endothelial injury.
Topics: Animals; Antibodies; Aspirin; Blood Coagulation; Blood Flow Velocity; Carotid Artery Injuries; Carot | 2000 |
Effect of aspirin on platelet desaggregation induced by SR121566, a potent GP-IIb/IIIa antagonist.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Benzylamines; Blood Flow Velocity; Blood | 2000 |
Dynamic intracoronary thrombosis does not cause significant downstream platelet embolization.
Topics: Analysis of Variance; Animals; Aspirin; Coronary Thrombosis; Disease Models, Animal; Female; Male; M | 2000 |
PEP trial. Pulmonary Embolism Prevention.
Topics: Animals; Aspirin; Cause of Death; Cyclooxygenase Inhibitors; Disease Models, Animal; Humans; Platele | 2000 |
Effects of acetyl salicylic acid therapy on an experimental thrombosis induced by laser beam.
Topics: Adenosine Diphosphate; Animals; Aspirin; Bleeding Time; Disease Models, Animal; Fibrinogen; Lasers; | 2000 |
Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis.
Topics: Age Factors; Animals; Aorta; Arteriosclerosis; Aspirin; Diet, Atherogenic; Disease Models, Animal; E | 2000 |
Time related neutralization of two doses acetyl salicylic acid.
Topics: Animals; Aspirin; Bleeding Time; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Eval | 2000 |
Pharmacological properties of a newly synthesized H(+)/K(+) ATPase inhibitor, 1-(2-methyl-4-methoxyphenyl)-4-.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cysteamine; Disease Models, Animal; Dose-Response Relationship, | 2001 |
Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Anti-Inflammatory Agents, Non- | 2001 |
Successful and not so successful chemoprevention of tobacco smoke-induced lung tumors.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Chemoprevention; Cyclohexenes; Dexamethasone; Diet; Disea | 2000 |
Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Aspirin; Disease | 2001 |
An in vivo rat model to study calcitonin gene related peptide release following activation of the trigeminal vascular system.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcitonin Gene-Related Peptide; Disease | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Effects of selective cyclooxygenase-2 inhibition on vascular responses and thrombosis in canine coronary arteries.
Topics: Acetylcholine; Animals; Arachidonic Acid; Aspirin; Benzofurans; Blood Flow Velocity; Celecoxib; Coro | 2001 |
Up-regulation of gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide by aspirin but not indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Disease Models, Animal; Gastri | 2001 |
Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Base Pair Mismatch; Colorectal Neoplasms, | 2001 |
Evaluation of the effects of nicorandil on experimentally induced gastric ulcers.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Dose-Response Relationship, | 2001 |
Platelet inhibition reduces cyclic flow variations and neointimal proliferation in normal and hypercholesterolemic-atherosclerotic canine coronary arteries.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Animals; Aspirin; Blood Coagulation; Blood Flo | 2001 |
Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspirin; Behavior, Animal; Cyclooxygenase Inhibito | 2001 |
Thrombostatin inhibits cyclic flow variations in stenosed canine coronary arteries.
Topics: Animals; Aspirin; Blood Coagulation Tests; Bradykinin; Clopidogrel; Coronary Stenosis; Coronary Thro | 2001 |
Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis.
Topics: Aging; Angioplasty, Balloon, Coronary; Animals; Aspirin; Coronary Restenosis; Coronary Vessels; Dise | 2002 |
Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.
Topics: Acute Disease; Animals; Aspirin; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygen | 2001 |
Prophylactic and curative effects of Bacopa monniera in gastric ulcer models.
Topics: Acetic Acid; Animals; Antioxidants; Aspirin; Catalase; Cell Division; Cold Temperature; Disease Mode | 2001 |
The effect of aspirin and prostaglandin E(1) on the patency of microvascular anastomosis in the rats.
Topics: Administration, Oral; Alprostadil; Anastomosis, Surgical; Animals; Aspirin; Carotid Arteries; Caroti | 2001 |
Thrombostatin, a bradykinin metabolite, reduces platelet activation in a model of arterial wall injury.
Topics: Animals; Aspirin; Blood Platelets; Bradykinin; Carotid Arteries; Carotid Artery Injuries; Carotid St | 2002 |
Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain.
Topics: Adenosine Triphosphatases; Animals; Antigens, CD; Apyrase; Aspirin; Brain Ischemia; Disease Models, | 2002 |
Transatrial access to the normal pericardial space for local cardiac therapy: preclinical safety testing with aspirin and pulmonary artery hypertension.
Topics: Animals; Aspirin; Disease Models, Animal; Heart Atria; Hypertension, Pulmonary; Pericardium; Pulmona | 2001 |
Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers.
Topics: Administration, Oral; Animals; Aspirin; Carbachol; Depression, Chemical; Disease Models, Animal; Duo | 1977 |
Inhibitors of gastric lesions in the rat.
Topics: Animals; Aspirin; Disease Models, Animal; Female; Glutamine; Histamine Antagonists; Indomethacin; Li | 1978 |
Antiplatelet drugs in a rat microsurgical model of arterial thrombosis.
Topics: Animals; Aspirin; Blood Coagulation; Blood Platelets; Carotid Artery Thrombosis; Dipyridamole; Disea | 1979 |
Experimental arterial thromboembolism in baboons. Mechanism, quantitation, and pharmacologic prevention.
Topics: Animals; Arteriovenous Shunt, Surgical; Aspirin; Blood Platelets; Blood Transfusion; Dipyridamole; D | 1979 |
Development and treatment of post-traumatic pulmonary platelet trapping.
Topics: Animals; Aspirin; Biopsy; Blood Cell Count; Blood Platelets; Chromium Radioisotopes; Dextrans; Disea | 1975 |
Single and multiple drug therapy in autologous immune complex nephritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azathioprine; Basement Membrane; Compleme | 1976 |
Stress ulceration and the gastric mucosal barrier.
Topics: Animals; Aspirin; Bile Acids and Salts; Cats; Disease Models, Animal; Ethanol; Gastric Acidity Deter | 1975 |
The effect of prostaglandin E2, 15-methyl prostaglandin E2, and metiamide on established canine gastric mucosal barrier damage.
Topics: Administration, Topical; Animals; Aspirin; Cell Membrane Permeability; Disease Models, Animal; Dogs; | 1979 |
Salicylate intoxication and influenza in ferrets.
Topics: Animals; Arginase; Argininosuccinate Lyase; Aspartate Aminotransferases; Aspirin; Carbamoyl-Phosphat | 1979 |
Cimetidine protects against stress-induced gastric injury augmented by mucosal barrier breakers.
Topics: Animals; Aspirin; Cimetidine; Disease Models, Animal; Female; Gastric Mucosa; Guanidines; Rats; Stom | 1979 |
Inhibition by aspirin of gastrointestinal toxicity induced by indomethacin in polyarthritic rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Disease Models, Animal; Dose-Response Relation | 1979 |
Effects of heparin, aspirin and dipyridamole on thrombus formation on venous catheters.
Topics: Animals; Aspirin; Catheterization; Dipyridamole; Disease Models, Animal; Face; Heparin; Polyethylene | 1979 |
Inhibitors of platelet function and atherogenesis.
Topics: Animals; Arteriosclerosis; Aspirin; Blood Platelets; Dipyridamole; Disease Models, Animal; Humans; P | 1979 |
Migraine, platelets, and headache prophylaxis.
Topics: Animals; Aspirin; Blood Platelets; Disease Models, Animal; Humans; Migraine Disorders; Platelet Aggr | 1978 |
A new mechanical method for measuring rat paw edema.
Topics: Animals; Aspirin; Carrageenan; Disease Models, Animal; Edema; Male; Methods; Rats | 1978 |
Comparison of antithrombotic activity of heparin, ASA, sulfinpyrazone and VK 744 in a rat model of arterial thrombosis.
Topics: Animals; Aspirin; Blood Coagulation; Carotid Arteries; Carotid Artery Thrombosis; Disease Models, An | 1978 |
Distention ulcer as a model for testing of drugs for ulcerogenic side effects.
Topics: Animals; Aspirin; Disease Models, Animal; Hydrochloric Acid; Indomethacin; Male; Rats; Stomach; Stom | 1978 |
Indomethacin and lysine acetylsalicylate in rats with autologous nephrotoxic serum nephritis. Biochemical and morphological studies.
Topics: Animals; Aspirin; Basement Membrane; Disease Models, Animal; Female; Glomerulonephritis; Immune Sera | 1978 |
The effects of aspirin and indomethacin on the ocular response to circulating bacterial endotoxin in the rabbit.
Topics: Animals; Aspirin; Disease Models, Animal; Dogs; Endotoxins; Escherichia coli; Eye; Female; Indometha | 1976 |
Prostaglandins and the hemodynamic course of endotoxin shock.
Topics: Animals; Aspirin; Blood Pressure; Cardiac Output; Disease Models, Animal; Haplorhini; Hemodynamics; | 1976 |
Effects of antiinflammatory agents on the acute response of immune synovitis in rabbits.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Colchicine; Disease Models, Animal; Dose-Response Relati | 1977 |
Nephropathy and urinary stones in hyperuricemic rats. The effect of aspirin.
Topics: Animals; Aspirin; Disease Models, Animal; Granuloma; Male; Nephritis; Rats; Uric Acid; Urinary Calcu | 1977 |
[Characterization of the sodium nucleinate-edema of the rat paw].
Topics: Animals; Aspirin; Dextrans; Disease Models, Animal; Edema; Escin; Nucleic Acids; Ovalbumin; Phenylbu | 1977 |
Alteration of Hepatic microsomal enzyme systems and the lethal action of non-steroidal anti-arthritic drugs in acute and chronic models of inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Carrageenan; Chr | 1977 |
Activity of anti-inflammatory drugs on an experimental model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cartilage, Articular; Catalase; Disease Models, Animal; | 1976 |
Arachidonate-induced cerebrovascular occlusion in the rat. The role of platelets and aspirin in stroke.
Topics: Animals; Arachidonic Acids; Aspirin; Cerebral Cortex; Cerebrovascular Disorders; Disease Models, Ani | 1976 |
[Experimental thrombosis and treatment with acetylsalicylic acid in animals].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Disease Models, Animal; Germ-Free Life; Heparin; Rats; T | 1976 |
Evaluation of antithrombotic properties of suloctidil in comparison with aspirin and dipyridamole.
Topics: Animals; Aspirin; Dipyridamole; Disease Models, Animal; Drug Evaluation, Preclinical; Fibrinolytic A | 1976 |
Effects of carbenoxolone Na on acute and chronic gastric ulcer models in experimental animals.
Topics: Acute Disease; Animals; Aspirin; Carbenoxolone; Chronic Disease; Disease Models, Animal; Dogs; Gastr | 1976 |
The effect of a potent inhibitor of platelet aggregation, BL-3459, on adrenaline-induced myocardial necrosis in beagle dogs.
Topics: Animals; Aspirin; Blood Pressure; Disease Models, Animal; Dogs; Epinephrine; Female; Imidazoles; Mal | 1976 |
Anti-ulcer effects of 4'-(2-carboxyetyl) phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride (cetraxate) on various experimental gastric ulcers in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Cortisone; Cyclohexanecarboxylic Acids; Disease Model | 1976 |
The discriminability of apsirin in arthritic and nonarthritic rats.
Topics: Animals; Arthritis, Rheumatoid; Aspirin; Diagnosis, Differential; Discrimination Learning; Disease M | 1976 |
[Comparative studies on the antithrombotic effect of acetylsalicylic acid and anticoagulants on an experimental model of thrombosis].
Topics: Animals; Anticoagulants; Aspirin; Disease Models, Animal; Rabbits; Thrombosis | 1976 |
Extracorporeal model for study of factors affecting thrombus formation.
Topics: Animals; Aspirin; Blood Coagulation; Blood Flow Velocity; Disease Models, Animal; Dogs; Drug Synergi | 1975 |
A sensitive method for the comparative bioassay of nonsteroidal anti-inflammatory compounds in adjuvant-induced primary inflammation in the rat.
Topics: Aminopyrine; Analysis of Variance; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin | 1975 |
Conjunctival temperature: a measure of ocular decongestant and anti-inflammatory activity.
Topics: Administration, Oral; Administration, Topical; Animals; Antazoline; Anti-Inflammatory Agents; Aspiri | 1975 |
Protective effect of Pepto-Bismol liquid on the gastric mucosa of rats.
Topics: Animals; Aspirin; Bismuth; Cold Temperature; Disease Models, Animal; Ethanol; Gastric Mucosa; Peptic | 1975 |
Proceedings: The anti-thrombotic effect of warfarin, dipyridamole and aspirin in the rat.
Topics: Animals; Aspirin; Dipyridamole; Disease Models, Animal; Rats; Thrombosis; Warfarin | 1975 |
Cholesterol gallstones and aspirin.
Topics: Animals; Aspirin; Cholelithiasis; Cholesterol; Cricetinae; Disease Models, Animal; Dogs; Male; Mesoc | 1992 |
[Evaluation of the antithrombotic effects of pentoxifylline, acetylsalicylic acid and low molecular weight heparin in the laser model of thrombosis].
Topics: Animals; Aspirin; Disease Models, Animal; Heparin, Low-Molecular-Weight; In Vitro Techniques; Lasers | 1992 |
Focal cerebral ischemia in rats: effect of hemodilution with alpha-alpha cross-linked hemoglobin on CBF.
Topics: Animals; Aspirin; Brain; Brain Ischemia; Cerebrovascular Circulation; Cross-Linking Reagents; Diseas | 1992 |
Arterial thrombosis model with photochemical reaction in guinea-pig and its property.
Topics: Animals; Aspirin; Biphenyl Compounds; Disease Models, Animal; Femoral Artery; Fibrinolytic Agents; G | 1992 |
Cardioprotective effects of ischaemic preconditioning are not mediated by prostanoids.
Topics: Animals; Aspirin; Coronary Disease; Disease Models, Animal; Female; Heart; Myocardial Infarction; My | 1992 |
The effect of antiplatelet therapy on platelet accumulation after experimental angioplasty in the rabbit iliac model.
Topics: Angioplasty, Balloon; Animals; Arteriosclerosis; Aspirin; Dipyridamole; Disease Models, Animal; Drug | 1992 |
Synergistic antithrombotic properties of G4120, a RGD-containing synthetic peptide, and argatroban, a synthetic thrombin inhibitor, in a hamster femoral vein platelet-rich thrombosis model.
Topics: Animals; Antithrombins; Arginine; Aspirin; Blood Coagulation; Cricetinae; Disease Models, Animal; Dr | 1992 |
The de-endothelialized rat carotid arterial graft: a versatile experimental model for the investigation of arterial thrombosis.
Topics: Anastomosis, Surgical; Animals; Aspirin; Blood Coagulation Tests; Blood Vessel Prosthesis; Carotid A | 1992 |
Comparative arterial antithrombotic activity of clopidogrel and acetyl salicylic acid in the pig.
Topics: Animals; Aspirin; Bleeding Time; Clopidogrel; Disease Models, Animal; Female; Femoral Artery; Fibrin | 1992 |
Effect of aspirin on the fibrinolytic response in perfused rat hindquarters.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Disease Models, Animal; Endothelium, Vascular; Fibri | 1992 |
Aspirin pretreatment reduces ethanol withdrawal severity in a mouse model of binge drinking.
Topics: Alcoholism; Animals; Aspirin; Body Weight; Disease Models, Animal; Ethanol; Male; Mice; Mice, Inbred | 1992 |
A non-occlusive model of arterial thrombus formation in the rat and its modification by inhibitors of platelet function, or thrombin activity.
Topics: Animals; Aorta; Aspirin; Disease Models, Animal; Immunoenzyme Techniques; Infusions, Intravenous; In | 1992 |
Experimental carotid stenosis and endothelial injury in the rabbit: an in vivo model to study intravascular platelet aggregation.
Topics: Animals; Arachidonic Acid; Aspirin; Carotid Stenosis; Disease Models, Animal; Endothelium, Vascular; | 1992 |
A monoclonal antibody against the platelet glycoprotein IIb/IIIa receptor complex prevents platelet aggregation and thrombosis in a canine model of coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Animals; Antibodies, Monoclonal; Aspirin; Coronary Circulation; Coro | 1991 |
Effects of hemorrhagic shock, aspirin, and ethanol on secretagogue-induced experimental pancreatitis.
Topics: Amylases; Animals; Aspirin; Blood Pressure; Cathepsin B; Ceruletide; Disease Models, Animal; Ethanol | 1990 |
A reliable method for the production of antral gastric ulcer by a combination of 2-deoxy-D-glucose, aspirin and ammonia in rats.
Topics: Administration, Oral; Ammonia; Animals; Aspirin; Deoxyglucose; Disease Models, Animal; Drug Interact | 1991 |
Prevention by DV-7028, a selective 5-HT2 receptor antagonist, of the formation of coronary thrombi in dogs.
Topics: Animals; Aspirin; Coronary Thrombosis; Disease Models, Animal; Dogs; Drug Administration Schedule; P | 1991 |
Protective effects of dazmegrel on the PAF potential of ouabain-induced cardiac arrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Aspirin; Disease Models, Animal; Drug Synergism; Female; Guinea Pigs; | 1991 |
[Arterioarterial shunt coated with collagen. A model of acute arterial thrombosis for testing antithrombotic agents in rats].
Topics: Animals; Aspirin; Carotid Arteries; Clopidogrel; Collagen; Disease Models, Animal; Fistula; Graft Oc | 1991 |
Irreversible damage to the medullary interstitium in experimental analgesic nephropathy in F344 rats.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Disease Models, Animal; Female; Kidney Concentrating Ab | 1991 |
Increased susceptibility of the portal hypertensive gastric mucosa to damage.
Topics: Animals; Aspirin; Bile Acids and Salts; Disease Models, Animal; Ethanol; Gastric Mucosa; Hypertensio | 1991 |
Picotamide protects mice from death in a pulmonary embolism model by a mechanism independent from thromboxane suppression.
Topics: Animals; Aspirin; Disease Models, Animal; Epoprostenol; Male; Mice; Phthalic Acids; Platelet Aggrega | 1990 |
A new model for photochemically induced thrombosis in the inner ear microcirculation and the use of hearing loss as a measure for microcirculatory disorders.
Topics: Action Potentials; Animals; Aspirin; Cochlea; Disease Models, Animal; Ear, Inner; Hair Cells, Audito | 1990 |
The prominent role of thromboxane A2 formation on early pulmonary hypertension induced by oleic acid administration in sheep.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Platelets; Blood Pressure; Disease Models, Ani | 1990 |
Experimental analgesic nephropathy: changes in renal structure and urinary concentrating ability in Fischer 344 rats given continuous low doses of aspirin and paracetamol.
Topics: Acetaminophen; Animals; Aspirin; Body Weight; Disease Models, Animal; Female; Kidney Concentrating A | 1990 |
Comparison of two experimental thrombosis models in rats effects of four glycosaminoglycans.
Topics: Animals; Arteriovenous Shunt, Surgical; Aspirin; Blood Coagulation Factors; Blood Platelets; Chondro | 1989 |
Modulation of resynthesis of 1-alkyl-2-arachidonyl-glycero-3-phosphocholine and phosphatidylinositols for interception in vivo of free arachidonic acid, lyso-PAF, diacyl-glycerols, and phosphoinositides.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Burns; Diglycerides; Disease Models, Animal; | 1989 |
The differentiation of NSAIDs and prostaglandin action using a mechanical visceral pain model in the rat.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; Dose-Re | 1989 |
Application of a laser-induced endothelial injury model in the screening of antithrombotic drugs.
Topics: Animals; Aspirin; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelium, Vascular; Fibri | 1988 |
Can acid inhibitors be "true" cytoprotective agents?
Topics: Animals; Aspirin; Benzodiazepinones; Disease Models, Animal; Ethanol; Gastric Acid; Gastric Mucosa; | 1985 |
Hepatic metabolic alterations in rats treated with low-dose endotoxin and aspirin: an animal model of Reye's syndrome.
Topics: Acyl Coenzyme A; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aspirin; Disease Models, An | 1989 |
A sensitive model of venous thrombosis in rats.
Topics: Animals; Anticoagulants; Aspirin; Dipyridamole; Disease Models, Animal; Female; Heparin; Ketanserin; | 1986 |
The effect of nifedipine alone or combined with low dose acetylsalicyclic acid on endotoxin-induced pulmonary hypertension in the piglet.
Topics: Animals; Animals, Newborn; Aspirin; Disease Models, Animal; Drug Combinations; Drug Evaluation, Prec | 1988 |
An experimental study of analgesic nephropathy in rabbit. A light microscopic study.
Topics: Acetaminophen; Animals; Aspirin; Disease Models, Animal; Drug Combinations; Drug Synergism; Pyelitis | 1988 |
[Tracheal instillation of arachidonic acid as an asthma model in guinea pigs--preliminary results of the effect of inhibitors of arachidonic acid metabolism].
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Cyclooxygenase Inhibitors; Disease Mo | 1988 |
Inhibition of lipoxygenase (LOX) or of cyclooxygenase (COX) improves survival of rats in endotoxin shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Cyclooxygenase Inhibitors; Disease Models, Animal; L | 1988 |
Preventive effects of batroxobin on experimental canine coronary thrombosis.
Topics: Animals; Aspirin; Batroxobin; Coronary Disease; Coronary Thrombosis; Disease Models, Animal; Dogs; E | 1988 |
Indomethacin-induced gastric antral ulcers in hamsters.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cricetinae; Dinoprostone; Disease Models, Animal | 1988 |
A possible drug interaction between aspirin and L-glutamine on some experimental inflammatory and analgesic models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; Drug Interactions | 1988 |
Novel method for producing standard subacute gastric ulcer in rats and for the quantitative evaluation of the healing process. Effect of several drugs on healing.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Disease | 1988 |
[The effectiveness of the combined treatment of thrombocytic hemorrhagic diathesis of dogs with prednisolone and blood transfusion in the model of an aspirin-produced thrombocytopathy].
Topics: Animals; Aspirin; Bleeding Time; Blood Platelet Disorders; Blood Preservation; Blood Transfusion; Co | 1988 |
[Effect of various doses of aspirin on the development of aseptic thrombotic aortic endocarditis experimentally induced in the rabbit].
Topics: Animals; Aortic Diseases; Aspirin; Cardiac Catheterization; Disease Models, Animal; Dose-Response Re | 1988 |
Effect of dietary lipids on arterial thrombus formation: rationale for the support of drug therapy by diet.
Topics: Animals; Arteriosclerosis; Aspirin; Diet, Atherogenic; Dietary Fats; Disease Models, Animal; Fish Oi | 1988 |
A new experimental model of venous thrombosis in rats involving partial stasis and slight endothelium alterations.
Topics: Animals; Anticoagulants; Aspirin; Blood Platelets; Disease Models, Animal; Endothelium; Male; Micros | 1987 |
The thrombopenic effect of ellagic acid in the rat. Another model of platelet stimulation "in vivo".
Topics: Animals; Aspirin; Benzopyrans; Blood Platelets; Disease Models, Animal; Ellagic Acid; Female; Fibrin | 1987 |
Effect of the cyclo-oxygenase inhibitor indobufen on platelet accumulation in prosthetic vascular grafts.
Topics: Animals; Aspirin; Blood Vessel Prosthesis; Dipyridamole; Disease Models, Animal; Dogs; Drug Evaluati | 1986 |
Response of epithelial cells of the choroid plexus in the ferret model for Reye's syndrome.
Topics: Animals; Aspirin; Choroid Plexus; Disease Models, Animal; Epithelium; Ferrets; Male; Microscopy, Ele | 1987 |
[The modes of anti-inflammatory and analgesic actions of aspirin and salicylic acid].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Disease Models | 1985 |
Evidence that the rat is not an appropriate model to study the role of prostaglandins in normal or abnormal platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Blood Pressure; Disease Models, Animal; Ep | 1986 |
The effect of antithrombotics in a new model of arterial thrombosis.
Topics: Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fibrinolytic Age | 1986 |
Animal models for the study of atypical anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzydamine; Cortisone; Disease M | 1986 |
The ferret as a model for inner ear research.
Topics: Animals; Animals, Laboratory; Arginine; Aspirin; Carnivora; Disease Models, Animal; Ear, Inner; Ferr | 1985 |
Influenza B virus model of Reye's syndrome in mice: the effect of aspirin.
Topics: Animals; Aspartate Aminotransferases; Aspirin; Brain; Disease Models, Animal; Dose-Response Relation | 1985 |
Aspirin and the prevention of experimental arterial thrombosis: difficulty in establishing unequivocal effectiveness.
Topics: Animals; Aspirin; Disease Models, Animal; Male; Rats; Rats, Inbred Strains; Statistics as Topic; Thr | 1985 |
Platelet-induced vitreous membrane formation.
Topics: Animals; Aspirin; Blood Platelets; Chromatography, Gel; Disease Models, Animal; Endoplasmic Reticulu | 1973 |
Correlations between pathological changes in the hind paws of rats with adjuvant arthritis and their response to anti-inflammatory and analgesic drugs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Body Temperature; Bod | 1973 |
The prophylactic and therapeutic effects of gold sodium thiomalate against adjuvant-induced polyarthritis in rats.
Topics: Adjuvants, Immunologic; Animals; Arthritis; Aspirin; Blood Sedimentation; Body Weight; Disease Model | 1973 |
[Efficacy of different antiphlogistic agents with respect to carrageenan-inflammation, compared with other models of inflammation].
Topics: Adrenocorticotropic Hormone; Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; D | 1971 |
A modification of rat adjuvant arthritis for testing antirheumatic drugs.
Topics: Adjuvants, Immunologic; Aminopyrine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthr | 1972 |
Aspirin-flurbiprofen interaction in the adjuvant-induced polyarthritic rat.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Biphenyl Compounds; Chromatograph | 1974 |
Alterations in platelet aggregation associated with adjuvant arthritis in rats.
Topics: Adenosine Diphosphate; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin | 1974 |
Antithrombotic drugs and experimental thrombosis.
Topics: Animals; Aspirin; Dextrans; Dipyridamole; Disease Models, Animal; Drug Combinations; Fibrinolytic Ag | 1972 |
[Thromboembolism prevention after heart valve prosthesis in an experimental model].
Topics: Animals; Anticoagulants; Aspirin; Dipyridamole; Disease Models, Animal; Dogs; Heart Valve Prosthesis | 1972 |
Antagonism of cholera enterotoxin by anti-inflammatory agents in the rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Body Fluids; Body Weight; Cholera; | 1972 |
Prevention of cholera-induced intestinal secretion in the cat by aspirin.
Topics: Animals; Aspirin; Cats; Cholera; Diarrhea; Disease Models, Animal; Female; Intestinal Secretions; Ma | 1972 |
[Release of edemas in the rat paw due to sodium nucleinate and their modification by antiphlorgistic agents].
Topics: Animals; Aspirin; Disease Models, Animal; Edema; Escherichia coli; Forelimb; Prednisolone; Pyrogens; | 1972 |
Studies on the mode of action of non-steroid anti-inflammatory drugs.
Topics: Animals; Aspirin; Cell Movement; Disease Models, Animal; Indomethacin; Inflammation; Leukocytes; Mef | 1972 |
Dipyridamole and aspirin tested against an experimental model of thrombosis.
Topics: Animals; Aspirin; Blood Vessels; Dipyridamole; Disease Models, Animal; Dogs; Hematoma; Hemorrhagic D | 1973 |
Chronic gastric ulcer induced by aspirin: an experimental model.
Topics: Animals; Aspirin; Chronic Disease; Disease Models, Animal; Gastric Juice; Gastric Mucosa; Glycoprote | 1973 |
Laser-induced thrombosis in the microcirculation of the hamster cheek pouch and its inhibition by acetylsalicyclic acid.
Topics: Animals; Aspirin; Cheek; Constriction; Cricetinae; Disease Models, Animal; Injections, Intraperitone | 1973 |
[Quantitative and qualitative behaviour of the thrombocytes during scalding shock in the rabbit (author's transl)].
Topics: Animals; Aspirin; Blood Platelets; Burns; Disease Models, Animal; Female; Platelet Adhesiveness; Rab | 1973 |
I. Drug sensitivity of rat adjuvant arthritis, induced with "adjuvants" containing no mineral oil components.
Topics: Animals; Arthritis; Aspirin; Disease Models, Animal; Flufenamic Acid; Freund's Adjuvant; Lipids; Mal | 1974 |
Some anti-inflammatory properties of ascorbic acid.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Ascorbic Acid; Aspirin; Carrageenan; Disease Models, A | 1972 |
Adjuvant-induced arthritis in rats. II. Drug effects on physiologic, biochemical and immunologic parameters.
Topics: Animals; Anti-Inflammatory Agents; Antibodies; Arthritis; Aspirin; Body Weight; Cyclophosphamide; Di | 1971 |
Response of "acute phase" globulins in different models of inflammation in rats.
Topics: Acute Disease; Adjuvants, Immunologic; Animals; Arthritis; Aspirin; Disease Models, Animal; Granulom | 1971 |
Slowed lysosomal enzyme release and its normalization by drugs in adjuvant-induced polyarthritis.
Topics: Acid Phosphatase; Amino Acids; Animals; Arthritis; Aspirin; Chronic Disease; Disease Models, Animal; | 1971 |
Effects of topical hydrocortisone and acetylsalicylic acid on the primary lesion of adjuvant-induced arthritis.
Topics: Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin | 1971 |
Comparison of gastric toxicity of acetylsalicylic acid with route of administration in the rat.
Topics: Animals; Aspirin; Disease Models, Animal; Gastric Acidity Determination; Gastric Juice; Gastric Muco | 1971 |
Thrombosis prevention by acetylsalicylic acid in hyperlipemic rats.
Topics: Adenine Nucleotides; Adult; Animals; Aspirin; Blood Coagulation Tests; Collagen; Disease Models, Ani | 1970 |
Platelet response to induction of hemorrhagic pancreatitis.
Topics: Animals; Anti-Bacterial Agents; Aspirin; Blood Cell Count; Dipyridamole; Disease Models, Animal; Dog | 1971 |