Page last updated: 2024-10-23

aspirin and Diabetes Mellitus, Type 1

aspirin has been researched along with Diabetes Mellitus, Type 1 in 98 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.

Research Excerpts

ExcerptRelevanceReference
", aspirin alone (330 mg 3 times daily) or in combination with dipyridamole (75 mg 3 times daily), was tested versus placebo in 475 patients with early diabetic retinopathy."9.06Effect of aspirin alone and aspirin plus dipyridamole in early diabetic retinopathy. A multicenter randomized controlled clinical trial. The DAMAD Study Group. ( , 1989)
" Following a three week course of aspirin (330 mg)--dipyridamole (75 mg) taken three times daily there was significant reduction in exercise-induced albuminuria (expressed as the ratio of albumin excretion rate during exercise to that at rest before exercise) when compared to administration of placebo (P less than 0."9.06Reduction of exercise-induced albuminuria by aspirin-dipyridamole in patients with diabetes mellitus. ( Davies, JA; Hopper, AH; Tindall, H; Urquhart, S, 1987)
"The incidence of preeclampsia was similar in the 1254 women in the aspirin group and the 1249 women in the placebo group (aspirin, 18 percent; placebo, 20 percent; P=0."6.69Low-dose aspirin to prevent preeclampsia in women at high risk. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. ( Caritis, S; Hauth, J; Klebanoff, M; Landon, M; Lindheimer, MD; Meis, P; Miodovnik, M; Paul, R; Sibai, B; Thom, E; Thurnau, G; VanDorsten, P, 1998)
"Type 1 diabetes mellitus was established by intraperitoneal injection of streptozotocin (65 mg/kg)."5.91Long-term aspirin administration suppresses inflammation in diabetic cystopathy. ( Du, H; Li, N; Liu, J; Qin, Y; Xu, F; Xu, Y; Zhang, J, 2023)
"Glucose concentrations within target, appropriate gestational weight gain, adequate lifestyle, and, if necessary, antihypertensive treatment and low-dose aspirin reduces the risk of pre-eclampsia, preterm delivery, and other adverse pregnancy and neonatal outcomes in pregnancies complicated by type 1 diabetes."5.41Management of type 1 diabetes in pregnancy: update on lifestyle, pharmacological treatment, and novel technologies for achieving glycaemic targets. ( Battelino, T; Benhalima, K; Beunen, K; Buschur, E; Donovan, LE; Feig, DS; Kudva, YC; Levy, CJ; Mathiesen, ER; Mathieu, C; Murphy, HR; Painter, R; Polsky, S; Ringholm, L; Siegelaar, SE, 2023)
"We describe a patient with type 1 diabetes who had infarction of the muscles in her right thigh."5.30Enhanced platelet aggregation, high homocysteine level, and microvascular disease in diabetic muscle infarctions: implications for therapy. ( Levy, J; Ragatzki, P; Rajkumar, V; Sima, A, 1999)
"This was a prospective observation of pregnancy outcomes among 462 women with pregestational diabetes mellitus (White classes B-F) and singleton pregnancies who were enrolled in a multicenter trial to compare low-dose aspirin with placebo for preeclampsia prevention."5.09Risks of preeclampsia and adverse neonatal outcomes among women with pregestational diabetes mellitus. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. ( Caritis, S; Dombrowski, M; Hauth, J; Klebanoff, M; Landon, M; Lindheimer, M; MacPherson, C; McNellis, D; Meis, P; Miodovnik, M; Paul, R; Roberts, J; Sibai, BM; Thurnau, G; VanDorsten, JP, 2000)
", aspirin alone (330 mg 3 times daily) or in combination with dipyridamole (75 mg 3 times daily), was tested versus placebo in 475 patients with early diabetic retinopathy."5.06Effect of aspirin alone and aspirin plus dipyridamole in early diabetic retinopathy. A multicenter randomized controlled clinical trial. The DAMAD Study Group. ( , 1989)
" Following a three week course of aspirin (330 mg)--dipyridamole (75 mg) taken three times daily there was significant reduction in exercise-induced albuminuria (expressed as the ratio of albumin excretion rate during exercise to that at rest before exercise) when compared to administration of placebo (P less than 0."5.06Reduction of exercise-induced albuminuria by aspirin-dipyridamole in patients with diabetes mellitus. ( Davies, JA; Hopper, AH; Tindall, H; Urquhart, S, 1987)
"Aspirin administration, reduced the protein expression of Mysm1, increased the protein expression of H2AK119-Ub and thereby reduced the Set7 protein expression in glomeruli isolated from diabetic animals and prevented renal fibrosis."3.88Novel reno-protective mechanism of Aspirin involves H2AK119 monoubiquitination and Set7 in preventing type 1 diabetic nephropathy. ( Gaikwad, AB; Goru, SK, 2018)
"Aspirin use for primary prevention in patients at high risk with diabetes mellitus (DM) is often recommended under the assumption that most patients with DM have coronary artery disease (CAD)."3.83Value of Coronary Computed Tomography Angiography in Tailoring Aspirin Therapy for Primary Prevention of Atherosclerotic Events in Patients at High Risk With Diabetes Mellitus. ( Bax, JJ; de Graaf, MA; Delgado, V; Dimitriu-Leen, AC; Jukema, JW; Kharagjitsingh, AV; Knuuti, J; Kroft, LJ; Scholte, AJ; van den Hoogen, IJ; van Rosendael, AR; Wolterbeek, R, 2016)
" This adherence was concerned particularly with co-medication in patients diagnosed with hypertension, aspirin prescription in elderly patients and the achievement of target lipid levels following the prescription of statins."3.79Sex-specific-differences in cardiometabolic risk in type 1 diabetes: a cross-sectional study. ( Hintersteiner, J; Johnson, J; Kamyar, MR; Kautzky, A; Kautzky-Willer, A; Lemmens-Gruber, R; Saukel, J; Stich, K, 2013)
"A total of 48 participants with type 1 diabetes and 48 healthy controls were randomised to receive aspirin 75 or 300 mg once-daily (OD) in an open-label crossover study."3.01A randomised controlled trial to assess the antithrombotic effects of aspirin in type 1 diabetes: role of dosing and glycaemic control. ( Ajjan, RA; Grant, PJ; Hawkins, F; Kurdee, Z; Naseem, KM; Parker, WAE; Sagar, R; Storey, RF, 2021)
"Patients with type 1 diabetes form a less permeable fibrin network, which could contribute to their increased risk of cardiovascular disease (CVD)."2.77High-dose aspirin is required to influence plasma fibrin network structure in patients with type 1 diabetes. ( Adamson, U; Antovic, A; Jörneskog, G; Lins, PE; Mageed, K; Mobarrez, F; Tehrani, S; Wallén, HN, 2012)
"Preeclampsia is a severe pregnancy complication with high potential for adverse effects on maternal and fetal health during the perinatal period."2.72Family History of Hypertension, Cardiovascular Disease, or Diabetes and Risk of Developing Preeclampsia: A Systematic Review. ( Kay, VR; Smith, GN; Wedel, N, 2021)
"Aspirin sensitivity was defined as inhibition (i."2.71Aspirin sensitivity of platelet aggregation in diabetes mellitus. ( Albert, SG; Hasnain, BI; Joist, JH; Mooradian, AD; Ritter, DG, 2005)
"The incidence of preeclampsia was similar in the 1254 women in the aspirin group and the 1249 women in the placebo group (aspirin, 18 percent; placebo, 20 percent; P=0."2.69Low-dose aspirin to prevent preeclampsia in women at high risk. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. ( Caritis, S; Hauth, J; Klebanoff, M; Landon, M; Lindheimer, MD; Meis, P; Miodovnik, M; Paul, R; Sibai, B; Thom, E; Thurnau, G; VanDorsten, P, 1998)
"Accommodative amplitudes in Early Treatment Diabetic Retinopathy Study patients were lower than normal accommodative amplitudes."2.68Accommodative amplitudes in the Early Treatment Diabetic Retinopathy Study. ( Benson, WE; Braun, CI; Chew, EY; Ferris, FL; Remaley, NA, 1995)
"Patients with asymptomatic internal carotid artery stenosis exceeding 60% reduction in diameter who are acceptable candidates for elective operation may be considered for CEA if the combined arteriographic and surgical complication rates are 3% or less."2.68An analysis of perioperative surgical mortality and morbidity in the asymptomatic carotid atherosclerosis study. ACAS Investigators. Asymptomatic Carotid Atherosclerosis Study. ( Broderick, JP; Cohen, SN; Dempsey, RJ; Ernst, CB; Hosking, JD; Moore, WS; Robertson, JT; Toole, JF; Young, B, 1996)
"In the IDDM patients, baseline LDF (median: 27 (19-35); interquartile range) vs."2.67Peripheral macro- and microcirculation in short-term insulin-dependent diabetes mellitus: the role of prostaglandins in early haemodynamic changes. ( Bouhouch, E; Houben, AJ; Nieuwenhuijzen Kruseman, AC; Schaper, NC; Slaaf, DW, 1993)
"Aspirin resistance has been often considered a guilty actor, although many mechanisms have been mistaken for true aspirin resistance, such as patient poor compliance, inadequate dosing, drug interactions, and high-platelet turnover."2.58Aspirin in primary prevention for patients with diabetes: Still a matter of debate. ( Bonaventura, A; Liberale, L; Montecucco, F, 2018)
"Careful counseling of women with diabetic nephropathy before pregnancy with estimation of the risk for the mother and fetus is important."2.48Obstetric nephrology: pregnancy in women with diabetic nephropathy--the role of antihypertensive treatment. ( Clausen, P; Damm, P; Feldt-Rasmussen, B; Mathiesen, ER; Ringholm, L, 2012)
"Insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE) are two common autoimmune disorders that affect women of childbearing age."2.39Nutritional consequences of chronic maternal conditions during pregnancy and lactation: lupus and diabetes. ( Ferris, AM; Reece, EA, 1994)
"Type 1 diabetes mellitus was established by intraperitoneal injection of streptozotocin (65 mg/kg)."1.91Long-term aspirin administration suppresses inflammation in diabetic cystopathy. ( Du, H; Li, N; Liu, J; Qin, Y; Xu, F; Xu, Y; Zhang, J, 2023)
"Treatment of aspirin significantly prevented the progression of nephropathy and inhibited the augmented COX-2, NFkappaB (p65 levels), TNFalpha, and TGFbeta-smad expression."1.36Combination of aspirin with telmisartan suppresses the augmented TGFbeta/smad signaling during the development of streptozotocin-induced type I diabetic nephropathy. ( Gaikwad, AB; Mulay, SR; Tikoo, K, 2010)
" In this study, we investigated the effect of high-dose and long-term use of acetyl salicylic acid (ASA) on the streptozotocin-induced diabetic rats as a model of type I diabetes, with consideration on the structure and/or function of proteins."1.35Investigation of the mechanisms involved in the high-dose and long-term acetyl salicylic acid therapy of type I diabetic rats. ( Bathaie, SZ; Hassan, MZ; Jafarnejad, A; Nakhjavani, M, 2008)
"Aspirin resistance was not related to age, glycohemoglobin, total cholesterol, or a history of cardiovascular disease."1.33Comparison of aspirin resistance in type 1 versus type 2 diabetes mellitus. ( Aaronson, A; Abrahamson, M; Goldfine, AB; Mehta, SS; Silver, RJ, 2006)
" An independent endpoint review committee adjudicated all reported major adverse cardiovascular events, stent thromboses, and target-vessel revascularizations."1.33Safety of coronary sirolimus-eluting stents in daily clinical practice: one-year follow-up of the e-Cypher registry. ( Berge, C; Deme, M; Gershlick, AH; Guagliumi, G; Guyon, P; Lotan, C; Schofer, J; Seth, A; Sousa, JE; Stoll, HP; Urban, P; Wijns, W, 2006)
"During follow-up 56 recurrences occurred, making a total of 110 episodes of vitreous haemorrhage in 79 eyes of 54 patients."1.32Does cardiovascular therapy affect the onset and recurrence of preretinal and vitreous haemorrhage in diabetic eye disease? ( Banerjee, S; Denniston, AK; Dodson, PM; Gibson, JM, 2004)
"We describe a patient with type 1 diabetes who had infarction of the muscles in her right thigh."1.30Enhanced platelet aggregation, high homocysteine level, and microvascular disease in diabetic muscle infarctions: implications for therapy. ( Levy, J; Ragatzki, P; Rajkumar, V; Sima, A, 1999)
"Aspirin treatment also reduced the slope of the aggregation curve and increased the lag time (the period between the addition of collagen and the start of irreversible aggregation) significantly more in control than in diabetic platelets."1.28Differential effect of aspirin on platelet aggregation in IDDM. ( Burke, V; Douglas, AJ; McCulloch, RK; Mori, TA; Vandongen, R, 1992)

Research

Studies (98)

TimeframeStudies, this research(%)All Research%
pre-199017 (17.35)18.7374
1990's22 (22.45)18.2507
2000's36 (36.73)29.6817
2010's17 (17.35)24.3611
2020's6 (6.12)2.80

Authors

AuthorsStudies
Parker, WAE1
Sagar, R1
Kurdee, Z1
Hawkins, F1
Naseem, KM1
Grant, PJ1
Storey, RF1
Ajjan, RA1
Benhalima, K1
Beunen, K1
Siegelaar, SE1
Painter, R1
Murphy, HR1
Feig, DS1
Donovan, LE1
Polsky, S1
Buschur, E1
Levy, CJ1
Kudva, YC1
Battelino, T1
Ringholm, L2
Mathiesen, ER2
Mathieu, C2
Du, H1
Xu, F1
Liu, J1
Zhang, J1
Qin, Y1
Xu, Y1
Li, N1
Hameed, AB1
Combs, CA1
Kay, VR1
Wedel, N1
Smith, GN1
Ju, L1
McFadyen, JD1
Al-Daher, S1
Alwis, I1
Chen, Y1
Tønnesen, LL1
Maiocchi, S1
Coulter, B1
Calkin, AC1
Felner, EI1
Cohen, N1
Yuan, Y1
Schoenwaelder, SM1
Cooper, ME1
Zhu, C1
Jackson, SP1
Goru, SK1
Gaikwad, AB2
Bonaventura, A1
Liberale, L1
Montecucco, F1
Monif, GRG1
Egan, AM1
Brassill, MJ1
Brosnan, E1
Carmody, L1
Clarke, H1
Coogan Kelly, C1
Culliney, L1
Durkan, M1
Fenlon, M1
Ferry, P1
Hanlon, G1
Higgins, T1
Hoashi, S1
Khamis, A1
Kinsley, B1
Kinsley, T1
Kirwan, B1
Liew, A1
McGurk, C1
McHugh, C1
Murphy, MS1
Murphy, P1
O'Halloran, D1
O'Mahony, L1
O'Sullivan, E1
Nolan, M1
Peter, M1
Roberts, G1
Smyth, A1
Todd, M1
Tuthill, A1
Wan Mahmood, WA1
Yousif, O1
P Dunne, F1
Kautzky-Willer, A1
Stich, K1
Hintersteiner, J1
Kautzky, A1
Kamyar, MR1
Saukel, J1
Johnson, J1
Lemmens-Gruber, R1
Zaccardi, F1
Rizzi, A1
Petrucci, G1
Ciaffardini, F1
Tanese, L1
Pagliaccia, F1
Cavalca, V1
Ciminello, A1
Habib, A1
Squellerio, I1
Rizzo, P1
Tremoli, E1
Rocca, B1
Pitocco, D2
Patrono, C1
Wisinski, JA1
Kimple, ME1
Dimitriu-Leen, AC1
Scholte, AJ1
van Rosendael, AR1
van den Hoogen, IJ1
Kharagjitsingh, AV1
Wolterbeek, R1
Knuuti, J1
Kroft, LJ1
Delgado, V1
Jukema, JW1
de Graaf, MA1
Bax, JJ1
Chiva-Blanch, G1
Suades, R1
Padró, T1
Vilahur, G1
Peña, E1
Ybarra, J1
Pou, JM1
Badimon, L1
Belch, J1
MacCuish, A1
Campbell, I1
Cobbe, S1
Taylor, R1
Prescott, R1
Lee, R1
Bancroft, J1
MacEwan, S1
Shepherd, J1
Macfarlane, P1
Morris, A1
Jung, R1
Kelly, C1
Connacher, A1
Peden, N1
Jamieson, A1
Matthews, D1
Leese, G1
McKnight, J1
O'Brien, I1
Semple, C1
Petrie, J1
Gordon, D1
Pringle, S1
MacWalter, R1
Zaslavskaia, RM2
Tulemisov, EU2
Pulcinelli, FM1
Biasucci, LM1
Riondino, S1
Giubilato, S1
Leo, A1
Di Renzo, L1
Trifirò, E1
Mattiello, T1
Liuzzo, G1
Ghirlanda, G2
Crea, F1
Jackson, G1
Roffi, M1
Eberli, FR1
De La Cruz, JP4
Del Río, S1
Arrebola, MM3
López-Villodres, JA1
Jebrouni, N1
González-Correa, JA3
LaMarr, B1
Valdez, C1
Driscoll, K1
Ryan, M1
Mulay, SR1
Tikoo, K1
Ghannoum, JE1
Odingo, NA1
Provost, N1
Tehrani, S1
Antovic, A1
Mobarrez, F1
Mageed, K1
Lins, PE1
Adamson, U1
Wallén, HN1
Jörneskog, G1
Grove, EL1
Gregersen, S1
Feldt-Rasmussen, B1
Clausen, P1
Damm, P1
Serebruany, VL1
Dinicolantonio, JJ1
Can, MM1
Goto, S1
Bell, DS1
Bennett, KE1
Williams, D1
Feely, J1
Gysemans, C1
Stoffels, K1
Giulietti, A1
Overbergh, L1
Waer, M1
Lannoo, M1
Feige, U1
Fong, DS1
Aiello, L1
Gardner, TW1
King, GL1
Blankenship, G1
Cavallerano, JD1
Ferris, FL3
Klein, R2
Banerjee, S1
Denniston, AK1
Gibson, JM1
Dodson, PM1
Claudi, T1
Cooper, JG1
Hausken, MF1
Michaelsen, T1
Harboe, K1
Ingskog, W1
ØStrem, A1
Löbner, K1
Füchtenbusch, M1
Ragoobirsingh, D1
Morrison, EY1
Reid, HL1
Wilson, AM1
Boyle, AJ1
Fox, P1
Soedamah-Muthu, SS1
Stehouwer, CD1
Albert, SG1
Hasnain, BI1
Ritter, DG1
Joist, JH1
Mooradian, AD1
Charpentier, G1
Puel, J1
Steg, PG1
Brogan, GX1
Peterson, ED1
Mulgund, J1
Bhatt, DL1
Ohman, EM1
Gibler, WB1
Pollack, CV1
Farkouh, ME1
Roe, MT1
Watala, C1
Boncler, M1
Gresner, P1
Mehta, SS1
Silver, RJ1
Aaronson, A1
Abrahamson, M1
Goldfine, AB1
Urban, P1
Gershlick, AH1
Guagliumi, G1
Guyon, P1
Lotan, C1
Schofer, J1
Seth, A1
Sousa, JE1
Wijns, W1
Berge, C1
Deme, M1
Stoll, HP1
Cansino, AL1
Muñoz-Marín, J1
Guerrero, A2
Sánchez de la Cuesta, F4
Cañada, MJ1
Muñoz Marín, J1
Soares, PR1
Hueb, WA1
Lemos, PA1
Lopes, N1
Martinez, EE1
Cesar, LA1
Oliveira, SA1
Ramires, JA1
Kinduris, S1
Vaisvila, T1
Petronyte, J1
Budrikis, A1
Scheen, AJ1
Legrand, D1
Kraiem, S1
Abassi, C1
Annabi, N1
Smaali, I1
Issaa, I1
Wali, M1
Malou, M1
Hannachi, S1
Longo, S1
Battikh, K1
Slimane, ML1
Jafarnejad, A1
Bathaie, SZ1
Nakhjavani, M1
Hassan, MZ1
Podolecka, E1
Ciszewski, A1
Kepka, C1
Mazurkiewicz, Ł1
Ruzyłło, W1
Valone, J1
Giugliano, D1
Luyckx, AS1
Lefebvre, PJ1
Houben, AJ1
Nieuwenhuijzen Kruseman, AC1
Bouhouch, E1
Slaaf, DW1
Schaper, NC1
Ferris, AM1
Reece, EA1
De Cosmo, S1
Earle, K1
Morocutti, A1
Walker, J1
Ruggenenti, P1
Remuzzi, G1
Viberti, GC1
Homberg, M1
Tschöpe, D1
Greber, H1
Hackländer, T1
Schwippert, B1
Gries, FA1
Mödder, U1
Braun, CI1
Benson, WE1
Remaley, NA1
Chew, EY2
Feke, GT1
Yoshida, A1
Ogasawara, H1
Konno, S1
Goger, DG1
Buzney, SM1
McMeel, JW1
Franconi, F1
Miceli, M1
Fazzini, A1
Seghieri, G1
Caputo, S1
DiLeo, MA1
Lepore, D1
Young, B1
Moore, WS1
Robertson, JT1
Toole, JF1
Ernst, CB1
Cohen, SN1
Broderick, JP1
Dempsey, RJ1
Hosking, JD1
Ferris, F1
Husstedt, IW1
Grotemeyer, KH1
Evers, S1
Staschewski, F1
Wertelewski, R1
Simpfendorfer, C1
Kottke-Marchant, K1
Lowrie, M1
Anders, RJ1
Burns, DM1
Miller, DP1
Cove, CS1
DeFranco, AC1
Ellis, SG1
Moliterno, DJ1
Raymond, RE1
Sutton, JM1
Topol, EJ1
Colwell, JA1
Adamec, M1
Saudek, F1
Davis, MD1
Fisher, MR1
Gangnon, RE1
Barton, F1
Aiello, LM1
Knatterud, GL1
Caritis, S2
Sibai, B1
Hauth, J2
Lindheimer, MD1
Klebanoff, M2
Thom, E1
VanDorsten, P1
Landon, M2
Paul, R2
Miodovnik, M2
Meis, P2
Thurnau, G2
Rai, R1
Regan, L1
Moss, SE1
Klein, BE1
Wood, DM1
Plehwe, WE1
Colman, PG1
Rajkumar, V1
Ragatzki, P1
Sima, A1
Levy, J1
Sibai, BM1
Lindheimer, M1
VanDorsten, JP1
MacPherson, C1
Dombrowski, M1
Roberts, J1
McNellis, D1
Skyrme-Jones, RA2
Meredith, IT2
O'Brien, RC1
Hansen, HP1
Gaede, PH1
Jensen, BR1
Parving, HH1
Baron, BW1
Martin, MS1
Sucharetza, BS1
Jeon, H1
Baron, JM1
Teĭblium, MM1
Waitzman, MB1
Zannino, L1
Salvadori, G1
Eldor, A1
Diaz, EG1
Naparstek, E1
Manske, CL1
Wang, Y1
Rector, T1
Wilson, RF1
White, CW1
Ghiselli, A1
Laurenti, O1
De Mattia, G1
Maiani, G1
Ferro-Luzzi, A1
Mori, TA1
Vandongen, R1
Douglas, AJ1
McCulloch, RK1
Burke, V1
Patrassi, GM1
Martinelli, S1
Picchinenna, A1
Girolami, A1
Hopper, AH2
Tindall, H2
Davies, JA2
Ehrich, JH1
Wurster, U1
Lütge, M1
Doehring, E1
Oemar, B1
Pavia, J1
Garcia-Arnes, J1
Urquhart, S1
Aguilar Muñoz, A1
de la Cruz Cortés, JP1
Martos Crespo, F1
García Arnés, J1
de Pablo Molina, J1
DiMinno, G1
Silver, MJ1
Cerbone, AM1
Riccardi, G1
Rivellese, A1
Mancini, M1
Jones, DB1
Haitas, B1
Carter, RD1
Bown, E1
Mann, JI1
Amado, JA1
Suárez, M1
Richard, C1
Sedano, MC1
Kaye, R1
Athreya, BH1
Kunzman, EE1
Baker, L1

Clinical Trials (11)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Impact of Aspirin Dose Modification on the Innate Immune Response - Will Lower Dose Aspirin Therapy Reduce the Response to Endotoxin[NCT03869268]Phase 472 participants (Actual)Interventional2019-04-24Completed
Effects of Low and High Doses of Aspirin Treatment on Fibrin Network Formation in Patients With Type 1 Diabetes and Possible Influence of the Glycemic Control.[NCT01397513]Phase 448 participants (Actual)Interventional2006-03-31Completed
Testing the Effectiveness of Different Messaging Approaches to Increase Doctor Visits to Confirm or Exclude a Diagnosis of Prediabetes or Diabetes Amongst Individuals With Risk Factors for Diabetes: A Randomised, Controlled Trial[NCT05755555]5,000 participants (Actual)Interventional2022-08-04Active, not recruiting
Prospective, Single-Arm, Multi-Centre, Observational Registry to Further Validate Safety and Efficacy of the Nobori DES in Real-World Patients[NCT01261273]18,000 participants (Actual)Observational2010-08-25Completed
BIOTRONIK-Safety and Clinical PerFormance of the Drug ELuting Orsiro Stent in the Treatment of Subjects With de Novo Coronary Artery Lesions-VI[NCT02870985]Phase 3440 participants (Anticipated)Interventional2015-07-31Recruiting
Aqueous Biomarker Levels in Diabetic Retinopathy and Diabetic Macular Edema[NCT05333055]150 participants (Anticipated)Observational2022-04-11Not yet recruiting
[NCT00000151]Phase 30 participants Interventional1979-12-31Completed
Long-Term Efficacy and Safety of Intravitreal Aflibercept Injections for the Treatment of Diabetic Retinopathy for Subjects Who Completed the 2-Year PANORAMA Trial[NCT04708145]Phase 4150 participants (Anticipated)Interventional2021-06-01Active, not recruiting
Intravitreal Aflibercept for Retinal Non-Perfusion in Proliferative Diabetic Retinopathy[NCT02863354]Phase 243 participants (Actual)Interventional2016-08-31Completed
Intravitreal Aflibercept as Indicated by Real-Time Objective Imaging to Achieve Diabetic Retinopathy Improvement[NCT03531294]Phase 240 participants (Actual)Interventional2018-05-23Completed
Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial[NCT04855513]414 participants (Anticipated)Interventional2022-03-24Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Area of Retinal Capillary Non-perfusion Outside of the Macula

Change in area of retinal capillary non-perfusion outside of the macula from baseline to week 52 and week 100. (NCT02863354)
Timeframe: 52 weeks and 100 weeks

,
Interventionmm^2 (Mean)
Week 52Week 100
Q12WKS240.472387.204
Q4WKS182.467342.651

Change in Area of Retinal Capillary Non-perfusion Within the Macula

Change in area of retinal capillary non-perfusion within the macula compared to baseline, as assessed by ultrawide-field fluorescein angiogram from baseline to week 52 and week 100. (NCT02863354)
Timeframe: 52 weeks and 100 weeks

,
Interventionmm^2 (Mean)
Week 52Week 100
Q12WKS0.2170.940
Q4WKS0.0482.627

Change in Area of Total Retinal Capillary Non-perfusion, as Assessed by the Central Reading Center

Change in area of total retinal capillary non-perfusion, as assessed by the central reading center, at week 52 and week 100 compared to baseline. (NCT02863354)
Timeframe: 52 weeks and 100 weeks

,
Interventionmm^2 (Mean)
Week 52Week 100
Q12WKS66.752245.694
Q4WKS-11.994141.317

Change in Early Treatment of Diabetic Retinopathy Severity Best Corrected Visual Acuity

Mean change in Early Treatment of Diabetic Retinopathy Study Best Corrected Visual Acuity (ETDRS-BCVA) from baseline to week 52 and week 100. (NCT02863354)
Timeframe: 52 weeks and 100 weeks

,
InterventionETDRS letters (Mean)
Week 52Week 100
Q12WKS4.538.88
Q4WKS4.264.06

Changes in Visual Function Outcomes (Self Reported Visual Function)

Changes in self reported visual function utilizing the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) from baseline to week 52 and week 100. The NEI VFQ is a validated measure of patient-reported visual function measured on a scale from 0 (worst function) to 100 (best function). (NCT02863354)
Timeframe: 52 weeks and 100 weeks

,
Interventionunits on a scale (Mean)
Week 52Week 100
Q12WKS2.238.82
Q4WKS6.278.91

Mean Change in Central Subfield Thickness

Mean change in central subfield thickness (CST) from baseline to week 52 and week 100 (NCT02863354)
Timeframe: 52 weeks and 100 weeks

,
Interventionmicrometers (Mean)
Week 52Week 100
Q12WKS-20.813-23.313
Q4WKS-32.947-35.059

Number of Participants With Treatment-related Adverse Events as Assessed by CTCAE v4.0

• Assess the safety and tolerability of IAI for the treatment of proliferative diabetic retinopathy by evaluating the incidence and severity of ocular and systemic adverse events through week 52 and week 100. (NCT02863354)
Timeframe: 52 and 100 weeks

,
InterventionParticipants (Count of Participants)
Week 52Week 100
Q12WKS00
Q4WKS00

Percentage of Subjects Treated With Pan-retinal Photocoagulation or Vitrectomy

Percentage of subjects treated with PRP or vitrectomy for progression of PDR from baseline to week 52 and week 100. (NCT02863354)
Timeframe: 52 Weeks and 100 Weeks

,
InterventionParticipants (Count of Participants)
Week 52Week 100
Q12WKS00
Q4WKS00

Percentage of Subjects Who Develop Center-involving Diabetic Macular Edema

Percentage of subjects, at week 52 and week 100, who develop center-involving diabetic macular edema who did not have center-involving diabetic macular edema at baseline (NCT02863354)
Timeframe: 52 Weeks and 100 Weeks

,
InterventionParticipants (Count of Participants)
Week 52Week 100
Q12WKS00
Q4WKS00

Percentage of Subjects Who Develop Vitreous Hemorrhage

Percentage of subjects who develop vitreous hemorrhage from baseline to week 52 and week 100. (NCT02863354)
Timeframe: 52 Weeks and 100 Weeks

,
InterventionParticipants (Count of Participants)
Week 52Week 100
Q12WKS11
Q4WKS24

Percentage of Subjects With Increased Neovascularization

Percentage of subjects with increased neovascularization from baseline to week 52 and week 100. (NCT02863354)
Timeframe: 52 Weeks and 100 Weeks

,
InterventionParticipants (Count of Participants)
Week 52Week 100
Q12WKS00
Q4WKS10

Percentage of Subjects With Neovascularization Regression

Percentage of subjects with neovascularization regression (reduced area of neovascularization) as measured by the central image reading center from baseline to week 52 and week 100. (NCT02863354)
Timeframe: 52 Weeks and 100 Weeks

,
InterventionParticipants (Count of Participants)
Week 52Week 100
Q12WKS1815
Q4WKS1717

Reviews

17 reviews available for aspirin and Diabetes Mellitus, Type 1

ArticleYear
Management of type 1 diabetes in pregnancy: update on lifestyle, pharmacological treatment, and novel technologies for achieving glycaemic targets.
    The lancet. Diabetes & endocrinology, 2023, Volume: 11, Issue:7

    Topics: Antihypertensive Agents; Aspirin; Blood Glucose; Blood Glucose Self-Monitoring; Diabetes Mellitus, T

2023
Family History of Hypertension, Cardiovascular Disease, or Diabetes and Risk of Developing Preeclampsia: A Systematic Review.
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2021, Volume: 43, Issue:2

    Topics: Aspirin; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Female; Humans; Hypertension; Pre-Eclam

2021
Aspirin in primary prevention for patients with diabetes: Still a matter of debate.
    European journal of clinical investigation, 2018, Volume: 48, Issue:10

    Topics: Aspirin; Blood Platelets; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathie

2018
Diabetes and acute coronary syndromes.
    Best practice & research. Clinical endocrinology & metabolism, 2009, Volume: 23, Issue:3

    Topics: Acute Coronary Syndrome; Anticoagulants; Aspirin; Blood Glucose; Clopidogrel; Diabetes Mellitus; Dia

2009
Antiplatelet therapy in patients with diabetes mellitus.
    Current vascular pharmacology, 2012, Volume: 10, Issue:4

    Topics: Animals; Aspirin; Blood Platelets; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic An

2012
Obstetric nephrology: pregnancy in women with diabetic nephropathy--the role of antihypertensive treatment.
    Clinical journal of the American Society of Nephrology : CJASN, 2012, Volume: 7, Issue:12

    Topics: Albuminuria; Antihypertensive Agents; Aspirin; Counseling; Diabetes Mellitus, Type 1; Diabetes Melli

2012
Drugs for cardiovascular risk reduction in the diabetic patient.
    Current diabetes reports, 2001, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Diabetes Mellitus, Type 1

2001
[Inflammation and diabetes].
    MMW Fortschritte der Medizin, 2004, Sep-02, Volume: 146, Issue:35-36

    Topics: Adiponectin; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Arte

2004
[Cardiovascular protection and prevention in patients with cardiac conditions and diabetes].
    Presse medicale (Paris, France : 1983), 2005, Oct-22, Volume: 34, Issue:18

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Blood Glucose; Cardi

2005
Blood platelet abnormalities and pharmacological modulation of platelet reactivity in patients with diabetes mellitus.
    Pharmacological reports : PR, 2005, Volume: 57 Suppl

    Topics: Aspirin; Blood Platelets; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathie

2005
[Screening and management of coronary artery disease in diabetic patients].
    La Tunisie medicale, 2006, Volume: 84, Issue:10

    Topics: Adrenergic beta-Antagonists; Aged; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inh

2006
Proliferative diabetic retinopathy and patient age: presentation, prognosis, and management.
    International ophthalmology clinics, 1984,Winter, Volume: 24, Issue:4

    Topics: Adolescent; Adult; Age Factors; Anticoagulants; Aspirin; Diabetes Mellitus, Type 1; Diabetic Retinop

1984
Nutritional consequences of chronic maternal conditions during pregnancy and lactation: lupus and diabetes.
    The American journal of clinical nutrition, 1994, Volume: 59, Issue:2 Suppl

    Topics: Adult; Aspirin; Autoimmune Diseases; Diabetes Mellitus, Type 1; Female; Humans; Lactation Disorders;

1994
Antiphospholipid syndrome and pregnancy loss.
    Hospital medicine (London, England : 1998), 1998, Volume: 59, Issue:8

    Topics: Abortion, Habitual; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antiphospholipid Syndro

1998
Four patients with both thrombotic thrombocytopenic purpura and autoimmune thrombocytopenic purpura: the concept of a mixed immune thrombocytopenia syndrome and indications for plasma exchange.
    Journal of clinical apheresis, 2001, Volume: 16, Issue:4

    Topics: Adult; Arthritis, Rheumatoid; Aspirin; Autoimmune Diseases; Blood Platelets; Combined Modality Thera

2001
Proposed metabolic dysfunctions in diabetic microthromboses and microangiopathy.
    Metabolism: clinical and experimental, 1979, Volume: 28, Issue:4 Suppl 1

    Topics: Alprostadil; Aspirin; Blood Platelets; Calcimycin; Collagen; Cyclic AMP; Cyclic GMP; Diabetes Mellit

1979
[Platelet aggregation inhibitors. Their possible use in pediatric pathology].
    Minerva pediatrica, 1979, Jan-31, Volume: 31, Issue:2

    Topics: Age Factors; Anti-Inflammatory Agents; Aspirin; Child; Clofibrate; Dextrans; Diabetes Mellitus, Type

1979

Trials

23 trials available for aspirin and Diabetes Mellitus, Type 1

ArticleYear
A randomised controlled trial to assess the antithrombotic effects of aspirin in type 1 diabetes: role of dosing and glycaemic control.
    Cardiovascular diabetology, 2021, 12-17, Volume: 20, Issue:1

    Topics: Adolescent; Adult; Aspirin; Biomarkers; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 1

2021
The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease.
    BMJ (Clinical research ed.), 2008, Oct-16, Volume: 337

    Topics: Adult; Aged; Antioxidants; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic A

2008
[Correction of the disturbed coagulation circadian rhythm in patients with type 1 diabetes mellitus treated by aspirin chronotherapy].
    Klinicheskaia meditsina, 2008, Volume: 86, Issue:10

    Topics: Administration, Oral; Adolescent; Adult; Aspirin; Blood Coagulation; Circadian Rhythm; Diabetes Mell

2008
High-dose aspirin is required to influence plasma fibrin network structure in patients with type 1 diabetes.
    Diabetes care, 2012, Volume: 35, Issue:2

    Topics: Aspirin; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 1; Drug Administration Schedu

2012
Aspirin sensitivity of platelet aggregation in diabetes mellitus.
    Diabetes research and clinical practice, 2005, Volume: 70, Issue:2

    Topics: Aspirin; Cardiotonic Agents; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; M

2005
Coronary revascularization (surgical or percutaneous) decreases mortality after the first year in diabetic subjects but not in nondiabetic subjects with multivessel disease: an analysis from the Medicine, Angioplasty, or Surgery Study (MASS II).
    Circulation, 2006, Jul-04, Volume: 114, Issue:1 Suppl

    Topics: Adrenergic beta-Antagonists; Aged; Angioplasty, Balloon, Coronary; Angioplasty, Balloon, Laser-Assis

2006
Peripheral macro- and microcirculation in short-term insulin-dependent diabetes mellitus: the role of prostaglandins in early haemodynamic changes.
    European journal of clinical investigation, 1993, Volume: 23, Issue:10

    Topics: Adult; Aspirin; Blood Circulation; Blood Glucose; Diabetes Mellitus, Type 1; Double-Blind Method; Fe

1993
Glucose-induced changes in renal haemodynamics in proteinuric type 1 (insulin-dependent) diabetic patients: inhibition by acetylsalicilic acid infusion.
    Diabetologia, 1993, Volume: 36, Issue:7

    Topics: Adult; Analysis of Variance; Aspirin; Biopsy; Blood Proteins; Diabetes Mellitus, Type 1; Diabetic Ne

1993
Accommodative amplitudes in the Early Treatment Diabetic Retinopathy Study.
    Retina (Philadelphia, Pa.), 1995, Volume: 15, Issue:4

    Topics: Accommodation, Ocular; Adolescent; Adult; Age Factors; Aspirin; Diabetes Mellitus, Type 1; Diabetes

1995
Retinal blood flow increases following short-term aspirin usage in type I diabetics with no or minimal retinopathy.
    Ophthalmic research, 1996, Volume: 28, Issue:2

    Topics: Adult; Aspirin; Blood Flow Velocity; Cross-Over Studies; Diabetes Mellitus, Type 1; Diabetic Retinop

1996
An analysis of perioperative surgical mortality and morbidity in the asymptomatic carotid atherosclerosis study. ACAS Investigators. Asymptomatic Carotid Atherosclerosis Study.
    Stroke, 1996, Volume: 27, Issue:12

    Topics: Anesthesia; Arteriosclerosis; Aspirin; Carotid Stenosis; Cerebral Infarction; Combined Modality Ther

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
Early photocoagulation in patients with either type I or type II diabetes.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitu

1996
First chronic platelet glycoprotein IIb/IIIa integrin blockade. A randomized, placebo-controlled pilot study of xemilofiban in unstable angina with percutaneous coronary interventions.
    Circulation, 1997, Jul-01, Volume: 96, Issue:1

    Topics: Adult; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Benzamidines; Coronary Arter

1997
Risk factors for high-risk proliferative diabetic retinopathy and severe visual loss: Early Treatment Diabetic Retinopathy Study Report #18.
    Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:2

    Topics: Adolescent; Adult; Aged; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neu

1998
Low-dose aspirin to prevent preeclampsia in women at high risk. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units.
    The New England journal of medicine, 1998, Mar-12, Volume: 338, Issue:11

    Topics: Adult; Aspirin; Chronic Disease; Diabetes Mellitus, Type 1; Double-Blind Method; Female; Humans; Hyp

1998
Risks of preeclampsia and adverse neonatal outcomes among women with pregestational diabetes mellitus. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units.
    American journal of obstetrics and gynecology, 2000, Volume: 182, Issue:2

    Topics: Aspirin; Birth Weight; Blood Pressure; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female;

2000
Lack of impact of low-dose acetylsalicylic acid on kidney function in type 1 diabetic patients with microalbuminuria.
    Diabetes care, 2000, Volume: 23, Issue:12

    Topics: Adult; Albuminuria; Aspirin; Blood Pressure; Chromatography, High Pressure Liquid; Cross-Over Studie

2000
[Effects of aspirin standard therapy and chronotherapy on circadian organization of hemocoagulation in patients with insulin-dependent diabetes mellitus].
    Klinicheskaia meditsina, 2002, Volume: 80, Issue:2

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Coagulation; Chronotherap

2002
Coronary revascularisation in insulin-dependent diabetic patients with chronic renal failure.
    Lancet (London, England), 1992, Oct-24, Volume: 340, Issue:8826

    Topics: Adult; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Calcium Channel Blockers; Coronary

1992
Administration of aspirin-dipyridamole reduces proteinuria in diabetic nephropathy.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1989, Volume: 4, Issue:2

    Topics: Adult; Aspirin; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Dipyridamole; Double-Blind Method

1989
Effect of aspirin alone and aspirin plus dipyridamole in early diabetic retinopathy. A multicenter randomized controlled clinical trial. The DAMAD Study Group.
    Diabetes, 1989, Volume: 38, Issue:4

    Topics: Adult; Aspirin; Blood Pressure; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellit

1989
Reduction of exercise-induced albuminuria by aspirin-dipyridamole in patients with diabetes mellitus.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1987, Volume: 19, Issue:5

    Topics: Adult; Albuminuria; Aspirin; Diabetes Mellitus, Type 1; Dipyridamole; Drug Therapy, Combination; Hum

1987
[Effect of dipyridamole (225 mg/day) and acetylsalicylic acid (150 mg/day) on various platelet parameters in non-complicated diabetes mellitus].
    Medicina clinica, 1986, May-03, Volume: 86, Issue:17

    Topics: Aspirin; Blood Platelets; Diabetes Mellitus, Type 1; Dipyridamole; Humans; Malondialdehyde; Platelet

1986

Other Studies

58 other studies available for aspirin and Diabetes Mellitus, Type 1

ArticleYear
Long-term aspirin administration suppresses inflammation in diabetic cystopathy.
    Aging, 2023, 09-12, Volume: 15, Issue:17

    Topics: Animals; Aspirin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Inflammation; Male; Ra

2023
Society for Maternal-Fetal Medicine Special Statement: Updated checklist for antepartum care of pregestational diabetes mellitus.
    American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:5

    Topics: Aspirin; Checklist; Delivery, Obstetric; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disea

2020
Compression force sensing regulates integrin α
    Nature communications, 2018, 03-14, Volume: 9, Issue:1

    Topics: Adult; Animals; Aspirin; Blood Platelets; Clopidogrel; Diabetes Mellitus, Type 1; Female; Humans; Ma

2018
Novel reno-protective mechanism of Aspirin involves H2AK119 monoubiquitination and Set7 in preventing type 1 diabetic nephropathy.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:3

    Topics: Animals; Aspirin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies

2018
The myth of autoimmunity.
    Medical hypotheses, 2018, Volume: 121

    Topics: Antibodies; Antigens; Aspirin; Autoimmune Diseases; Autoimmunity; Crohn Disease; Diabetes Mellitus,

2018
ACOG Practice Bulletin No. 201 Summary: Pregestational Diabetes Mellitus.
    Obstetrics and gynecology, 2018, Volume: 132, Issue:6

    Topics: Administration, Oral; Aspirin; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2;

2018
An Irish National Diabetes in Pregnancy Audit: aiming for best outcomes for women with diabetes.
    Diabetic medicine : a journal of the British Diabetic Association, 2020, Volume: 37, Issue:12

    Topics: Abortion, Spontaneous; Adult; Aspirin; Cesarean Section; Clinical Audit; Delivery of Health Care; De

2020
Sex-specific-differences in cardiometabolic risk in type 1 diabetes: a cross-sectional study.
    Cardiovascular diabetology, 2013, May-24, Volume: 12

    Topics: Adult; Aspirin; Blood Pressure; Cardiovascular Diseases; Cross-Sectional Studies; Diabetes Complicat

2013
In Vivo Platelet Activation and Aspirin Responsiveness in Type 1 Diabetes.
    Diabetes, 2016, Volume: 65, Issue:2

    Topics: Adult; Albuminuria; Aspirin; Blood Glucose; Cross-Sectional Studies; Cyclooxygenase 1; Diabetes Mell

2016
Platelet Dysfunction in Type 1 Diabetes: Stressing the Thromboxanes.
    Diabetes, 2016, Volume: 65, Issue:2

    Topics: Aspirin; Diabetes Mellitus, Type 1; Epoprostenol; Female; Humans; Male; Platelet Activation; Platele

2016
Value of Coronary Computed Tomography Angiography in Tailoring Aspirin Therapy for Primary Prevention of Atherosclerotic Events in Patients at High Risk With Diabetes Mellitus.
    The American journal of cardiology, 2016, Mar-15, Volume: 117, Issue:6

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Mass Index; Coronary Angiography; Coron

2016
Microparticle Shedding by Erythrocytes, Monocytes and Vascular Smooth Muscular Cells Is Reduced by Aspirin in Diabetic Patients.
    Revista espanola de cardiologia (English ed.), 2016, Volume: 69, Issue:7

    Topics: Adult; Aged; Aspirin; Blood Platelets; Cardiovascular Diseases; Cell-Derived Microparticles; Diabete

2016
COX-1 sensitivity and thromboxane A2 production in type 1 and type 2 diabetic patients under chronic aspirin treatment.
    European heart journal, 2009, Volume: 30, Issue:10

    Topics: Adult; Aged; Aspirin; Blood Platelets; C-Reactive Protein; Case-Control Studies; Cyclooxygenase 1; D

2009
Aspirin: not currently for primary prevention in diabetes.
    International journal of clinical practice, 2009, Volume: 63, Issue:6

    Topics: Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Off-La

2009
Effect of virgin olive oil plus acetylsalicylic acid on brain slices damage after hypoxia-reoxygenation in rats with type 1-like diabetes mellitus.
    Neuroscience letters, 2010, Mar-03, Volume: 471, Issue:2

    Topics: Animals; Aspirin; Brain; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hypoxia, Brain;

2010
Influence of pharmacist intervention on prescribing of angiotensin-converting-enzyme inhibitors, angiotensin II-receptor blockers, and aspirin for diabetic patients.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2010, Feb-15, Volume: 67, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Con

2010
Combination of aspirin with telmisartan suppresses the augmented TGFbeta/smad signaling during the development of streptozotocin-induced type I diabetic nephropathy.
    Chemico-biological interactions, 2010, Apr-29, Volume: 185, Issue:2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin;

2010
Clinico-pathologic conference: case 6.
    Head and neck pathology, 2009, Volume: 3, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Carcinoma, Squamous Cell;

2009
Unclassified pleomorphic and spindle cell pulmonary neoplasm with brain metastases after prasugrel.
    Cardiology, 2013, Volume: 124, Issue:2

    Topics: Aged; Aspirin; Brain Neoplasms; Carcinoma; Clinical Trials, Phase III as Topic; Clopidogrel; Colonic

2013
Under-prescribing of cardiovascular therapies for diabetes in primary care.
    European journal of clinical pharmacology, 2003, Volume: 58, Issue:12

    Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibit

2003
Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents.
    Diabetologia, 2003, Volume: 46, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Diabetes Melli

2003
Retinopathy in diabetes.
    Diabetes care, 2004, Volume: 27 Suppl 1

    Topics: Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Humans; Laser C

2004
Does cardiovascular therapy affect the onset and recurrence of preretinal and vitreous haemorrhage in diabetic eye disease?
    Eye (London, England), 2004, Volume: 18, Issue:8

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Cardiovascular Agents; Cardiovascula

2004
[Risk intervention in persons with diabetes mellitus in general practice].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2004, Jun-03, Volume: 124, Issue:11

    Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Cardiovascular Diseases; Di

2004
Comparative blood studies in Jamaican diabetic patients.
    Journal of the National Medical Association, 2004, Volume: 96, Issue:11

    Topics: Aspirin; Blood Sedimentation; Blood Viscosity; Comorbidity; Diabetes Mellitus, Type 1; Erythrocyte A

2004
Management of ischaemic heart disease in women of child-bearing age.
    Internal medicine journal, 2004, Volume: 34, Issue:12

    Topics: Adult; Aspirin; Diabetes Mellitus, Type 1; Female; Fibrinolytic Agents; Humans; Hypoglycemic Agents;

2004
Cardiovascular disease morbidity and mortality in patients with type 1 diabetes mellitus : management strategies.
    Treatments in endocrinology, 2005, Volume: 4, Issue:2

    Topics: Antihypertensive Agents; Aspirin; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Humans; Hypogl

2005
Treatment disparities in the care of patients with and without diabetes presenting with non-ST-segment elevation acute coronary syndromes.
    Diabetes care, 2006, Volume: 29, Issue:1

    Topics: Acute Disease; Adrenergic beta-Antagonists; Adult; Aspirin; Cardiac Catheterization; Clopidogrel; Co

2006
Comparison of aspirin resistance in type 1 versus type 2 diabetes mellitus.
    The American journal of cardiology, 2006, Feb-15, Volume: 97, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Cholesterol, HDL; Diabetes Mellitu

2006
Safety of coronary sirolimus-eluting stents in daily clinical practice: one-year follow-up of the e-Cypher registry.
    Circulation, 2006, Mar-21, Volume: 113, Issue:11

    Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cause of Death; Clopidogrel; Comorbidity; Coronary Di

2006
Safety of coronary sirolimus-eluting stents in daily clinical practice: one-year follow-up of the e-Cypher registry.
    Circulation, 2006, Mar-21, Volume: 113, Issue:11

    Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cause of Death; Clopidogrel; Comorbidity; Coronary Di

2006
Safety of coronary sirolimus-eluting stents in daily clinical practice: one-year follow-up of the e-Cypher registry.
    Circulation, 2006, Mar-21, Volume: 113, Issue:11

    Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cause of Death; Clopidogrel; Comorbidity; Coronary Di

2006
Safety of coronary sirolimus-eluting stents in daily clinical practice: one-year follow-up of the e-Cypher registry.
    Circulation, 2006, Mar-21, Volume: 113, Issue:11

    Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cause of Death; Clopidogrel; Comorbidity; Coronary Di

2006
Effects of aspirin plus alpha-tocopherol on brain slices damage after hypoxia-reoxygenation in rats with type 1-like diabetes mellitus.
    Neuroscience letters, 2006, Jun-12, Volume: 400, Issue:3

    Topics: alpha-Tocopherol; Animals; Antioxidants; Aspirin; Brain Ischemia; Cells, Cultured; Diabetes Mellitus

2006
Antioxidant and antiplatelet effects of the alpha-tocopherol-aspirin combination in type 1-like diabetic rats.
    Life sciences, 2006, Sep-05, Volume: 79, Issue:15

    Topics: alpha-Tocopherol; Animals; Antioxidants; Aspirin; Diabetes Mellitus, Experimental; Diabetes Mellitus

2006
[Bleeding after cardiac surgery: risk factors, frequency, and outcomes].
    Medicina (Kaunas, Lithuania), 2006, Volume: 42, Issue:7

    Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Cardiac Surgical Procedures; Diabetes Mellitus,

2006
Aspirin and clopidogrel resistance in patients with diabetes mellitus.
    European heart journal, 2006, Volume: 27, Issue:23

    Topics: Aspirin; Clopidogrel; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; D

2006
Investigation of the mechanisms involved in the high-dose and long-term acetyl salicylic acid therapy of type I diabetic rats.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 324, Issue:2

    Topics: Animals; Aspirin; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty

2008
[Acetylsalicylic acid hypersensitivity in a patient with coronary artery disease and insulin-dependent diabetes mellitus].
    Kardiologia polska, 2008, Volume: 66, Issue:1

    Topics: Angioplasty, Balloon, Coronary; Aspirin; Coronary Angiography; Coronary Artery Disease; Desensitizat

2008
Effects of acetylsalicylic acid on blood glucose, plasma FFA, glycerol, 3-hydroxybutyrate, alanine, C-peptide, glucagon and growth hormone responses to arginine in insulin-dependent diabetics.
    Diabete & metabolisme, 1980, Volume: 6, Issue:1

    Topics: Adolescent; Adult; Alanine; Arginine; Aspirin; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1;

1980
[Optic neuropathy in type-1 diabetes and acetylsalicylic acid-refractory thrombocyte activation].
    Deutsche medizinische Wochenschrift (1946), 1993, Mar-05, Volume: 118, Issue:9

    Topics: Adult; Aspirin; Chronic Disease; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diabetic Neuropa

1993
Taurine and diabetes. Humans and experimental models.
    Advances in experimental medicine and biology, 1996, Volume: 403

    Topics: Animals; Arachidonic Acid; Aspirin; Blood Platelets; Diabetes Mellitus, Experimental; Diabetes Melli

1996
Progression of distal symmetric polyneuropathy during diabetes mellitus: clinical, neurophysiological, haemorheological changes and self-rating scales of patients.
    European neurology, 1997, Volume: 37, Issue:2

    Topics: Adolescent; Adult; Aged; Aspirin; Blood Glucose; Blood Viscosity; Diabetes Mellitus, Type 1; Diabete

1997
Aspirin therapy in diabetes mellitus.
    Diabetologia, 1997, Volume: 40, Issue:7

    Topics: Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Gastrointestin

1997
Our experience with pancreatic graft extraperitoneal placement.
    Transplantation proceedings, 1997, Volume: 29, Issue:7

    Topics: Adult; Anticoagulants; Aspirin; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Drug Therapy, Com

1997
The 14-year incidence of lower-extremity amputations in a diabetic population. The Wisconsin Epidemiologic Study of Diabetic Retinopathy.
    Diabetes care, 1999, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Age Factors; Age of Onset; Aged; Amputation, Surgical; Aspirin; Blood Pressure; D

1999
Aspirin usage in a large teaching hospital diabetes clinic setting.
    Diabetic medicine : a journal of the British Diabetic Association, 1999, Volume: 16, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Australia; Diabetes Mellitus, Type 1; Diabetes Mellitus, Ty

1999
Enhanced platelet aggregation, high homocysteine level, and microvascular disease in diabetic muscle infarctions: implications for therapy.
    Endocrine, 1999, Volume: 11, Issue:1

    Topics: Adult; Aspirin; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Female; Folic Acid; Hematinics; Ho

1999
Aspirin does not improve endothelial vasodilator function in Type 1 diabetes mellitus.
    Diabetic medicine : a journal of the British Diabetic Association, 2000, Volume: 17, Issue:7

    Topics: Acetylcholine; Adult; Aspirin; Blood Glucose; Brachial Artery; Diabetes Mellitus, Type 1; Endotheliu

2000
Vasodilator prostanoids, but not nitric oxide, may account for skeletal muscle hyperaemia in Type I diabetes mellitus.
    Clinical science (London, England : 1979), 2000, Volume: 99, Issue:5

    Topics: Adult; Area Under Curve; Aspirin; Case-Control Studies; Cyclooxygenase Inhibitors; Diabetes Mellitus

2000
Treatment of diabetic necrobiosis with aspirin and dipyridamole.
    The New England journal of medicine, 1978, May-04, Volume: 298, Issue:18

    Topics: Adult; Aspirin; Diabetes Mellitus, Type 1; Dipyridamole; Female; Humans; Necrobiosis Lipoidica

1978
Treatment of diabetic necrobiosis with aspirin or dipyridamole.
    The New England journal of medicine, 1978, 12-14, Volume: 299, Issue:24

    Topics: Adolescent; Adult; Animals; Aspirin; Diabetes Complications; Diabetes Mellitus, Type 1; Dipyridamole

1978
Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients.
    Free radical biology & medicine, 1992, Volume: 13, Issue:6

    Topics: Adult; Aspirin; Diabetes Mellitus, Type 1; Female; Gentisates; Humans; Hydroxybenzoates; Hydroxylati

1992
Differential effect of aspirin on platelet aggregation in IDDM.
    Diabetes, 1992, Volume: 41, Issue:3

    Topics: Adult; Aspirin; Blood Pressure; Cholesterol; Collagen; Diabetes Mellitus, Type 1; Fatty Acids, Omega

1992
Contact phase of coagulation in diabetes mellitus after aspirin administration.
    Folia haematologica (Leipzig, Germany : 1928), 1985, Volume: 112, Issue:2

    Topics: Aspirin; Blood Coagulation; Blood Platelets; Diabetes Mellitus, Type 1; Factor XI; Factor XII; Femal

1985
[Enzymuria and kidney diseases in childhood].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1986, Volume: 134, Issue:12

    Topics: Acetylglucosaminidase; Adolescent; Aminopeptidases; Anti-Bacterial Agents; Aspirin; CD13 Antigens; C

1986
Effects of triflusal and acetylsalicylic acid on platelet aggregation in whole blood of diabetic patients.
    European journal of haematology, 1988, Volume: 40, Issue:3

    Topics: Adult; Aspirin; beta-Thromboglobulin; Diabetes Mellitus, Type 1; Humans; Male; Platelet Aggregation;

1988
Platelet fibrinogen binding in diabetes mellitus. Differences between binding to platelets from nonretinopathic and retinopathic diabetic patients.
    Diabetes, 1986, Volume: 35, Issue:2

    Topics: Adolescent; Adult; Apyrase; Aspirin; Blood Platelets; Diabetes Mellitus, Type 1; Diabetic Retinopath

1986
Prostaglandin synthesis inhibition reduces platelet aggregation in diabetes mellitus.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1985, Volume: 17, Issue:1

    Topics: Aspirin; Diabetes Mellitus, Type 1; Dipyridamole; Humans; Platelet Aggregation; Prostaglandins

1985
Influence of acetylsalicylic acid on bleeding time and serum thromboxane B2 in diabetes mellitus type I.
    Diabete & metabolisme, 1985, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Aspirin; Bleeding Time; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Female;

1985
Antipyretics in patients with juvenile diabetes mellitus. Comparison of salicylate and a salicylate substitute (experimental preparation PAJ-102).
    American journal of diseases of children (1960), 1966, Volume: 112, Issue:1

    Topics: Acetaminophen; Adolescent; Aspirin; Blood Glucose; Child; Diabetes Mellitus, Type 1; Drug Administra

1966