aspirin has been researched along with Depressive Disorder in 14 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "High total plasma homocysteine (tHcy) is associated with increased risk of cardiovascular events and depression." | 7.78 | Aspirin decreases the risk of depression in older men with high plasma homocysteine. ( Alfonso, H; Almeida, OP; Flicker, L; Hankey, GJ; McCaul, K; Yeap, BB, 2012) |
| "Combining aspirin or nonsteroidal anti-inflammatory drugs with SSRIs for the treatment of interferon-associated neuropsychiatric side effects increases the risks of hemorrhage in patients with HCV who have developed cirrhosis and either portal hypertension or hepatic failure or both." | 6.20 | A critical review of selective serotonin reuptake inhibitor-associated bleeding: balancing the risk of treating hepatitis C-infected patients. ( Auriacombe, M; Chang, KM; Lewis, JD; Lynch, KG; Weinrieb, RM, 2003) |
| "To investigate whether continued use of non-aspirin NSAID, low-dose aspirin, high-dose aspirin, statins, allopurinol and angiotensin agents decreases the rate of incident depression using Danish nationwide population-based registers." | 3.91 | New drug candidates for depression - a nationwide population-based study. ( Andersen, PK; Berk, M; Ekstrøm, CT; Gerds, TA; Kessing, LV; Rytgaard, HC, 2019) |
| "High total plasma homocysteine (tHcy) is associated with increased risk of cardiovascular events and depression." | 3.78 | Aspirin decreases the risk of depression in older men with high plasma homocysteine. ( Alfonso, H; Almeida, OP; Flicker, L; Hankey, GJ; McCaul, K; Yeap, BB, 2012) |
| " All patients were prescribed a twice-per-day regimen of low dose aspirin to reduce their risk for myocardial infarction." | 3.69 | Major depression and medication adherence in elderly patients with coronary artery disease. ( Carney, RM; Eisen, SA; Freedland, KE; Jaffe, AS; Rich, MW, 1995) |
| "In many individuals with major neuropsychiatric disorders including depression, bipolar disorder and schizophrenia, their disease characteristics are consistent with a neuroprogressive illness." | 2.49 | Putative neuroprotective agents in neuropsychiatric disorders. ( Anderson, G; Berk, M; Dean, OM; Dodd, S; Maes, M; Moylan, S, 2013) |
| "Aspirin use was defined through self-report in the past 30 days and confirmed by a trained interviewer." | 1.48 | Aspirin and incident depressive symptoms: A longitudinal cohort study over 8 years. ( Carvalho, AF; Fernandes, BS; Fornaro, M; Koyanagi, A; Maggi, S; Mueller, C; Solmi, M; Stubbs, B; Thompson, T; Veronese, N, 2018) |
| "Although depressive disorders have been associated with increased risk of worse outcomes with cardiovascular diseases (CVDs), its relation with access to and quality of cardiovascular care is not well studied." | 1.48 | Impact of Depressive Disorder on Access and Quality of Care in Veterans With Prevalent Cardiovascular Disease. ( Butler, J; Lacey, M; Parikh, PB; Shroyer, AL; Srivastava, P, 2018) |
| "In patients with migraine, ECT may be expected to trigger a migraine attack, probably in the same way as spontaneous seizures." | 1.29 | Migraine after electroconvulsive therapy. ( Folkerts, H, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wium-Andersen, IK | 1 |
| Wium-Andersen, MK | 1 |
| Jørgensen, MB | 1 |
| Osler, M | 1 |
| Veronese, N | 1 |
| Koyanagi, A | 1 |
| Stubbs, B | 1 |
| Solmi, M | 1 |
| Fornaro, M | 1 |
| Fernandes, BS | 1 |
| Mueller, C | 1 |
| Thompson, T | 1 |
| Carvalho, AF | 1 |
| Maggi, S | 1 |
| Srivastava, P | 1 |
| Butler, J | 1 |
| Shroyer, AL | 1 |
| Lacey, M | 1 |
| Parikh, PB | 1 |
| Kessing, LV | 1 |
| Rytgaard, HC | 1 |
| Gerds, TA | 1 |
| Berk, M | 2 |
| Ekstrøm, CT | 1 |
| Andersen, PK | 1 |
| Bauer, IE | 1 |
| Green, C | 1 |
| Colpo, GD | 1 |
| Teixeira, AL | 1 |
| Selvaraj, S | 1 |
| Durkin, K | 1 |
| Zunta-Soares, GB | 1 |
| Soares, JC | 1 |
| Zafar, MU | 1 |
| Paz-Yepes, M | 1 |
| Shimbo, D | 1 |
| Vilahur, G | 1 |
| Burg, MM | 1 |
| Chaplin, W | 1 |
| Fuster, V | 1 |
| Davidson, KW | 1 |
| Badimon, JJ | 1 |
| Almeida, OP | 1 |
| Flicker, L | 1 |
| Yeap, BB | 1 |
| Alfonso, H | 1 |
| McCaul, K | 1 |
| Hankey, GJ | 1 |
| Dodd, S | 1 |
| Maes, M | 1 |
| Anderson, G | 1 |
| Dean, OM | 1 |
| Moylan, S | 1 |
| Weinrieb, RM | 1 |
| Auriacombe, M | 1 |
| Lynch, KG | 1 |
| Chang, KM | 1 |
| Lewis, JD | 1 |
| Serebruany, VL | 1 |
| Carney, RM | 1 |
| Freedland, KE | 1 |
| Eisen, SA | 1 |
| Rich, MW | 1 |
| Jaffe, AS | 1 |
| Folkerts, H | 1 |
| Shad, MU | 1 |
| Harvey, AT | 1 |
| Lucot, JB | 1 |
| Juárez-Olguín, H | 1 |
| Jung-Cook, H | 1 |
| Flores-Pérez, J | 1 |
| Lares-Asseff, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| ANGIOTENSIN AGENTS AND REDUCTION OF THE PRESCRIPTION OF ANTIDEPRESSANT DRUGS: A RETROSPECTIVE COHORT STUDY USING REAL-WORLD DATA[NCT04899206] | 120 participants (Anticipated) | Observational [Patient Registry] | 2021-04-12 | Active, not recruiting | |||
| A Double-blind Randomized Placebo-controlled Study of Aspirin and N-acetyl Cysteine as Adjunctive Treatments for Bipolar Disorder Patients (SMRI 11T-009)[NCT01797575] | Phase 2 | 38 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The MADRS is a ten-item diagnostic questionnaire used to measure the severity of depressive episodes in patients with mood disorders. A higher MADRS score indicates more severe depression, and each item yields a score of 0 to 6. The overall score ranges from 0 to 60. The questionnaire includes questions on the following symptoms: 1. Apparent sadness; 2. Reported sadness; 3. Inner tension; 4. Reduced sleep; 5. Reduced appetite; 6. Concentration difficulties; 7. Lassitude; 8. Inability to feel; 9. Pessimistic thoughts; and 10. Suicidal thoughts. This 30% MADRS reduction was analyzed in addition to initial outcome measures of 50% MADRS reduction due to the smaller than expected study sample size. (NCT01797575)
Timeframe: Received drug for 8 weeks during week 0 to week 8 of the study
| Intervention | Participants (Count of Participants) |
|---|---|
| Aspirin and NAC | 3 |
| Aspirin | 2 |
| N-Acetyl Cysteine (NAC) | 6 |
| Placebo | 7 |
The MADRS is a ten-item diagnostic questionnaire used to measure the severity of depressive episodes in patients with mood disorders. A higher MADRS score indicates more severe depression, and each item yields a score of 0 to 6. The overall score ranges from 0 to 60. The questionnaire includes questions on the following symptoms: 1. Apparent sadness; 2. Reported sadness; 3. Inner tension; 4. Reduced sleep; 5. Reduced appetite; 6. Concentration difficulties; 7. Lassitude; 8. Inability to feel; 9. Pessimistic thoughts; and 10. Suicidal thoughts. This 30% MADRS reduction was analyzed in addition to initial outcome measures of 50% MADRS reduction due to the smaller than expected study sample size. (NCT01797575)
Timeframe: Received drug for 8 weeks during week 9 to week 16 of the study
| Intervention | Participants (Count of Participants) |
|---|---|
| Aspirin and NAC | 4 |
| Aspirin | 3 |
| N-Acetyl Cysteine (NAC) | 3 |
| Placebo | 4 |
The MADRS is a ten-item diagnostic questionnaire used to measure the severity of depressive episodes in patients with mood disorders. A higher MADRS score indicates more severe depression, and each item yields a score of 0 to 6. The overall score ranges from 0 to 60. The questionnaire includes questions on the following symptoms: 1. Apparent sadness; 2. Reported sadness; 3. Inner tension; 4. Reduced sleep; 5. Reduced appetite; 6. Concentration difficulties; 7. Lassitude; 8. Inability to feel; 9. Pessimistic thoughts; and 10. Suicidal thoughts. (NCT01797575)
Timeframe: Received drug for 8 weeks during week 0 to week 8 of the study
| Intervention | Participants (Count of Participants) |
|---|---|
| Aspirin and NAC | 3 |
| Aspirin | 2 |
| N-Acetyl Cysteine (NAC) | 5 |
| Placebo | 6 |
The MADRS is a ten-item diagnostic questionnaire used to measure the severity of depressive episodes in patients with mood disorders. A higher MADRS score indicates more severe depression, and each item yields a score of 0 to 6. The overall score ranges from 0 to 60. The questionnaire includes questions on the following symptoms: 1. Apparent sadness; 2. Reported sadness; 3. Inner tension; 4. Reduced sleep; 5. Reduced appetite; 6. Concentration difficulties; 7. Lassitude; 8. Inability to feel; 9. Pessimistic thoughts; and 10. Suicidal thoughts. (NCT01797575)
Timeframe: Received drug for 8 weeks during week 9 to week 16 of the study
| Intervention | Participants (Count of Participants) |
|---|---|
| Aspirin and NAC | 3 |
| Aspirin | 1 |
| N-Acetyl Cysteine (NAC) | 3 |
| Placebo | 4 |
C-reactive protein (CRP) levels are blood test markers of inflammation. Higher CRP corresponds with higher levels of inflammation. CRP is measured in milligrams per liter. (NCT01797575)
Timeframe: baseline, week 8, week 16
| Intervention | milligrams per liter (Mean) | ||
|---|---|---|---|
| CRP at Baseline | CRP at Week 8 | CRP at Week 16 | |
| Aspirin | 6.85 | 6.82 | 10.76 |
| Aspirin and NAC | 5.1 | 17.02 | 9.39 |
| N-acetyl-cysteine | 17.65 | 41.09 | 17.69 |
| Sugar Pill | 17.30 | 7.4 | 13.10 |
Interleukin 6 (IL-6) is an interleukin that acts as a pro-inflammatory cytokine and an anti-inflammatory myokine. IL-6 is measured in picograms (pg) per milliliter (mL). Elevated interleukin-6 indicates potential immune system dysregulation and increased inflammation. (NCT01797575)
Timeframe: baseline, week 8, week 16
| Intervention | picograms per milliliter (Mean) | ||
|---|---|---|---|
| IL-6 at Baseline | IL-6 at Week 8 | IL-6 at Week 16 | |
| Aspirin | 1.27 | .78 | .90 |
| Aspirin and NAC | .85 | 1.76 | 1.72 |
| N-acetyl-cysteine | 3.22 | 3.53 | 2.6 |
| Sugar Pill | 2.3 | 1.87 | 1.71 |
3 reviews available for aspirin and Depressive Disorder
| Article | Year |
|---|---|
Putative neuroprotective agents in neuropsychiatric disorders.
Topics: Animals; Aspirin; Bipolar Disorder; Depressive Disorder; Humans; Lithium; Mental Disorders; Nerve Gr | 2013 |
A critical review of selective serotonin reuptake inhibitor-associated bleeding: balancing the risk of treating hepatitis C-infected patients.
Topics: Analgesics; Antidepressive Agents; Antiviral Agents; Aspirin; Depressive Disorder; Drug Interactions | 2003 |
Selective serotonin reuptake inhibitors and increased bleeding risk: are we missing something?
Topics: Aspirin; Clopidogrel; Depressive Disorder; Drug Interactions; Hemorrhage; Humans; Platelet Aggregati | 2006 |
2 trials available for aspirin and Depressive Disorder
| Article | Year |
|---|---|
A Double-Blind, Randomized, Placebo-Controlled Study of Aspirin and N-Acetylcysteine as Adjunctive Treatments for Bipolar Depression.
Topics: Acetylcysteine; Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 2018 |
A critical review of selective serotonin reuptake inhibitor-associated bleeding: balancing the risk of treating hepatitis C-infected patients.
Topics: Analgesics; Antidepressive Agents; Antiviral Agents; Aspirin; Depressive Disorder; Drug Interactions | 2003 |
10 other studies available for aspirin and Depressive Disorder
| Article | Year |
|---|---|
Anti-inflammatory treatment and risk for depression after first-time stroke in a cohort of 147 487 Danish patients.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Aspirin; Denmark; Depressive D | 2017 |
Aspirin and incident depressive symptoms: A longitudinal cohort study over 8 years.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Depressive Disorder; Female; Fibrinolytic Ag | 2018 |
Impact of Depressive Disorder on Access and Quality of Care in Veterans With Prevalent Cardiovascular Disease.
Topics: Age Distribution; Aged; Angina Pectoris; Antihypertensive Agents; Aspirin; Cardiovascular Diseases; | 2018 |
New drug candidates for depression - a nationwide population-based study.
Topics: Adult; Aged; Allopurinol; Angiotensins; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agen | 2019 |
Anxiety is a better predictor of platelet reactivity in coronary artery disease patients than depression.
Topics: Adenosine Diphosphate; Aged; Angina, Unstable; Anxiety Disorders; Aspirin; Clopidogrel; Cross-Sectio | 2010 |
Aspirin decreases the risk of depression in older men with high plasma homocysteine.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Aspirin; Australia; Cross-Sectional Studies; Depress | 2012 |
Major depression and medication adherence in elderly patients with coronary artery disease.
Topics: Aged; Aspirin; Coronary Disease; Depressive Disorder; Dose-Response Relationship, Drug; Female; Huma | 1995 |
Migraine after electroconvulsive therapy.
Topics: Antidepressive Agents; Aspirin; Combined Modality Therapy; Depressive Disorder; Dose-Response Relati | 1995 |
A possible pharmacokinetic interaction between fluoxetine and acetylsalicylic acid.
Topics: Adult; Arthralgia; Aspirin; Depressive Disorder; Drug Hypersensitivity; Drug Interactions; Fluoxetin | 1997 |
Adverse effects of imipramine are increased by interaction with ASA in depressed patients.
Topics: Adult; Antidepressive Agents, Tricyclic; Aspirin; Depressive Disorder; Drug Interactions; Female; Hu | 2000 |