Page last updated: 2024-10-23

aspirin and Delayed Hypersensitivity

aspirin has been researched along with Delayed Hypersensitivity in 15 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"Pretreatment with aspirin reduces the levels of cyclooxygenase metabolites in nasal secretions without affecting the immediate physiologic response to antigen or the expected increase in the levels of histamine, N-alpha-tosyl-L-arginine methyl ester-esterase activity, and leukotriene C4."2.66Experimentally induced nasal allergic responses. ( Adkinson, NF; Bascom, R; Kagey-Sobotka, A; Lichtenstein, LM; Naclerio, RM; Proud, D; Walden, SM, 1988)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-199010 (66.67)18.7374
1990's1 (6.67)18.2507
2000's3 (20.00)29.6817
2010's1 (6.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Castells, M1
Javeed, A1
Hou, Y1
Duan, K1
Zhang, B1
Shen, H1
Cao, Y1
Zhao, Y1
Schottelius, AJ1
Giesen, C1
Asadullah, K1
Fierro, IM1
Colgan, SP1
Bauman, J1
Guilford, W1
Perez, HD1
Parkinson, JF1
Erbagci, Z1
Stevenson, DD1
Pleskow, WW1
Simon, RA1
Mathison, DA1
Lumry, WR1
Schatz, M1
Zeiger, RS1
Bartocci, A1
Papademetriou, V1
Schlick, E1
Nisula, BC1
Chirigos, MA1
Sestini, P1
Refini, RM1
Pieroni, MG1
Vaghi, A1
Robuschi, M1
Bianco, S1
Geczy, AF1
de Weck, AL1
Finzi, AF1
Pigatto, PD1
Santoro, MG1
Favalli, C1
Mastino, A1
Jaffe, BM1
Esteban, M1
Garaci, E1
Walden, SM1
Proud, D1
Bascom, R1
Lichtenstein, LM1
Kagey-Sobotka, A1
Adkinson, NF1
Naclerio, RM1
Iurenev, PN1
Semenovich, NI1
Droszcz, W1
Riethling, AK1
Kochman, S1
Charreire, J1
Dubois de Montreynaud, JM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Dupilumab as add-on Therapy for Aspirin-exacerbated Respiratory Disease (AERD)[NCT03595488]Phase 211 participants (Actual)Interventional2018-09-05Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for aspirin and Delayed Hypersensitivity

ArticleYear
Rapid desensitization for hypersensitivity reactions to medications.
    Immunology and allergy clinics of North America, 2009, Volume: 29, Issue:3

    Topics: Anaphylaxis; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents;

2009
[What is known today about the immunology and biochemistry of asthma? Immunologic reaction in asthma].
    Gruzlica i choroby pluc; tuberculosis et pneumonologia, 1974, Volume: 42, Issue:12

    Topics: Adenylyl Cyclases; Allergens; Aspirin; Asthma; Bronchi; Desensitization, Immunologic; Drug Hypersens

1974
[Side effects of drugs and their causes].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1969, Jun-15, Volume: 24, Issue:12

    Topics: Aspirin; Diet; Drug Hypersensitivity; Drug Tolerance; Drug-Related Side Effects and Adverse Reaction

1969

Trials

3 trials available for aspirin and Delayed Hypersensitivity

ArticleYear
Aspirin-sensitive rhinosinusitis asthma: a double-blind crossover study of treatment with aspirin.
    The Journal of allergy and clinical immunology, 1984, Volume: 73, Issue:4

    Topics: Aspirin; Asthma; Clinical Trials as Topic; Double-Blind Method; Drug Hypersensitivity; Forced Expira

1984
Protective effect of inhaled lysine acetylsalicylate on allergen-induced early and late asthmatic reactions.
    The Journal of allergy and clinical immunology, 1997, Volume: 100, Issue:1

    Topics: Administration, Inhalation; Adolescent; Adult; Allergens; Anti-Inflammatory Agents, Non-Steroidal; A

1997
Experimentally induced nasal allergic responses.
    The Journal of allergy and clinical immunology, 1988, Volume: 81, Issue:5 Pt 2

    Topics: Antigens; Aspirin; Fluocinolone Acetonide; Humans; Hypersensitivity, Delayed; Mast Cells; Nasal Prov

1988

Other Studies

9 other studies available for aspirin and Delayed Hypersensitivity

ArticleYear
Aspirin significantly decreases the nonopsonic phagocytosis and immunogenicity of macrophages in mice.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011, Volume: 60, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chickens; Erythrocytes; Humans; Hypersens

2011
An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Dec-15, Volume: 169, Issue:12

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcimycin; Ce

2002
Multiple NSAID intolerance in chronic idiopathic urticaria is correlated with delayed, pronounced and prolonged autoreactivity.
    The Journal of dermatology, 2004, Volume: 31, Issue:5

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies;

2004
Effect of crude and purified human chorionic gonadotropin on murine delayed-type hypersensitivity: a role for prostaglandins.
    Cellular immunology, 1982, Volume: 71, Issue:2

    Topics: Animals; Aspirin; Chorionic Gonadotropin; Female; Hypersensitivity, Delayed; Indomethacin; Male; Mic

1982
Histocompatibility antigens and genetic control of the immune response in guinea-pigs. V. Evidence from further breeding studies for the polygenic control of the cellular immune response to structurally unrelated antigens in the guinea-pig.
    Journal of immunogenetics, 1977, Volume: 4, Issue:5

    Topics: Animals; Antigens; Aspirin; Breeding; Cattle; Dose-Response Relationship, Immunologic; Genes, MHC Cl

1977
[Up-date on urticaria].
    Minerva medica, 1986, Jul-31, Volume: 77, Issue:30-31

    Topics: Aspirin; Complement Activation; Drug Therapy, Combination; Histamine; Histamine H1 Antagonists; Huma

1986
Antiviral activity of a synthetic analog of prostaglandin A in mice infected with influenza A virus.
    Archives of virology, 1988, Volume: 99, Issue:1-2

    Topics: Animals; Antibodies, Viral; Antibody Formation; Aspirin; Female; Hypersensitivity, Delayed; Immunity

1988
[Desensitization therapy in myocardial infarct].
    Kardiologiia, 1970, Volume: 10, Issue:1

    Topics: Adrenal Glands; Amines; Aminopyrine; Aspirin; Autoimmune Diseases; Desensitization, Immunologic; Dip

1970
[Value of lymphoblastic transformation test (L.T.T.) in the diagnosis of delayed hypersensitivity and drug intolerance (682 cases)].
    La Presse medicale, 1969, Dec-06, Volume: 77, Issue:52

    Topics: Antigen-Antibody Reactions; Aspirin; Bacterial Proteins; Brucella; Candida; Diphtheria Toxin; Drug H

1969