aspirin has been researched along with Delayed Hypersensitivity in 15 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with aspirin reduces the levels of cyclooxygenase metabolites in nasal secretions without affecting the immediate physiologic response to antigen or the expected increase in the levels of histamine, N-alpha-tosyl-L-arginine methyl ester-esterase activity, and leukotriene C4." | 2.66 | Experimentally induced nasal allergic responses. ( Adkinson, NF; Bascom, R; Kagey-Sobotka, A; Lichtenstein, LM; Naclerio, RM; Proud, D; Walden, SM, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (66.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Castells, M | 1 |
| Javeed, A | 1 |
| Hou, Y | 1 |
| Duan, K | 1 |
| Zhang, B | 1 |
| Shen, H | 1 |
| Cao, Y | 1 |
| Zhao, Y | 1 |
| Schottelius, AJ | 1 |
| Giesen, C | 1 |
| Asadullah, K | 1 |
| Fierro, IM | 1 |
| Colgan, SP | 1 |
| Bauman, J | 1 |
| Guilford, W | 1 |
| Perez, HD | 1 |
| Parkinson, JF | 1 |
| Erbagci, Z | 1 |
| Stevenson, DD | 1 |
| Pleskow, WW | 1 |
| Simon, RA | 1 |
| Mathison, DA | 1 |
| Lumry, WR | 1 |
| Schatz, M | 1 |
| Zeiger, RS | 1 |
| Bartocci, A | 1 |
| Papademetriou, V | 1 |
| Schlick, E | 1 |
| Nisula, BC | 1 |
| Chirigos, MA | 1 |
| Sestini, P | 1 |
| Refini, RM | 1 |
| Pieroni, MG | 1 |
| Vaghi, A | 1 |
| Robuschi, M | 1 |
| Bianco, S | 1 |
| Geczy, AF | 1 |
| de Weck, AL | 1 |
| Finzi, AF | 1 |
| Pigatto, PD | 1 |
| Santoro, MG | 1 |
| Favalli, C | 1 |
| Mastino, A | 1 |
| Jaffe, BM | 1 |
| Esteban, M | 1 |
| Garaci, E | 1 |
| Walden, SM | 1 |
| Proud, D | 1 |
| Bascom, R | 1 |
| Lichtenstein, LM | 1 |
| Kagey-Sobotka, A | 1 |
| Adkinson, NF | 1 |
| Naclerio, RM | 1 |
| Iurenev, PN | 1 |
| Semenovich, NI | 1 |
| Droszcz, W | 1 |
| Riethling, AK | 1 |
| Kochman, S | 1 |
| Charreire, J | 1 |
| Dubois de Montreynaud, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dupilumab as add-on Therapy for Aspirin-exacerbated Respiratory Disease (AERD)[NCT03595488] | Phase 2 | 11 participants (Actual) | Interventional | 2018-09-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for aspirin and Delayed Hypersensitivity
| Article | Year |
|---|---|
Rapid desensitization for hypersensitivity reactions to medications.
Topics: Anaphylaxis; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; | 2009 |
[What is known today about the immunology and biochemistry of asthma? Immunologic reaction in asthma].
Topics: Adenylyl Cyclases; Allergens; Aspirin; Asthma; Bronchi; Desensitization, Immunologic; Drug Hypersens | 1974 |
[Side effects of drugs and their causes].
Topics: Aspirin; Diet; Drug Hypersensitivity; Drug Tolerance; Drug-Related Side Effects and Adverse Reaction | 1969 |
3 trials available for aspirin and Delayed Hypersensitivity
| Article | Year |
|---|---|
Aspirin-sensitive rhinosinusitis asthma: a double-blind crossover study of treatment with aspirin.
Topics: Aspirin; Asthma; Clinical Trials as Topic; Double-Blind Method; Drug Hypersensitivity; Forced Expira | 1984 |
Protective effect of inhaled lysine acetylsalicylate on allergen-induced early and late asthmatic reactions.
Topics: Administration, Inhalation; Adolescent; Adult; Allergens; Anti-Inflammatory Agents, Non-Steroidal; A | 1997 |
Experimentally induced nasal allergic responses.
Topics: Antigens; Aspirin; Fluocinolone Acetonide; Humans; Hypersensitivity, Delayed; Mast Cells; Nasal Prov | 1988 |
9 other studies available for aspirin and Delayed Hypersensitivity
| Article | Year |
|---|---|
Aspirin significantly decreases the nonopsonic phagocytosis and immunogenicity of macrophages in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chickens; Erythrocytes; Humans; Hypersens | 2011 |
An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcimycin; Ce | 2002 |
Multiple NSAID intolerance in chronic idiopathic urticaria is correlated with delayed, pronounced and prolonged autoreactivity.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; | 2004 |
Effect of crude and purified human chorionic gonadotropin on murine delayed-type hypersensitivity: a role for prostaglandins.
Topics: Animals; Aspirin; Chorionic Gonadotropin; Female; Hypersensitivity, Delayed; Indomethacin; Male; Mic | 1982 |
Histocompatibility antigens and genetic control of the immune response in guinea-pigs. V. Evidence from further breeding studies for the polygenic control of the cellular immune response to structurally unrelated antigens in the guinea-pig.
Topics: Animals; Antigens; Aspirin; Breeding; Cattle; Dose-Response Relationship, Immunologic; Genes, MHC Cl | 1977 |
[Up-date on urticaria].
Topics: Aspirin; Complement Activation; Drug Therapy, Combination; Histamine; Histamine H1 Antagonists; Huma | 1986 |
Antiviral activity of a synthetic analog of prostaglandin A in mice infected with influenza A virus.
Topics: Animals; Antibodies, Viral; Antibody Formation; Aspirin; Female; Hypersensitivity, Delayed; Immunity | 1988 |
[Desensitization therapy in myocardial infarct].
Topics: Adrenal Glands; Amines; Aminopyrine; Aspirin; Autoimmune Diseases; Desensitization, Immunologic; Dip | 1970 |
[Value of lymphoblastic transformation test (L.T.T.) in the diagnosis of delayed hypersensitivity and drug intolerance (682 cases)].
Topics: Antigen-Antibody Reactions; Aspirin; Bacterial Proteins; Brucella; Candida; Diphtheria Toxin; Drug H | 1969 |