Page last updated: 2024-10-23

aspirin and Degenerative Diseases, Central Nervous System

aspirin has been researched along with Degenerative Diseases, Central Nervous System in 8 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"Aspirin was substantially more effective than salicylate in reducing or delaying aggregation in human neuroblastoma cells grown in vitro, and in Caenorhabditis elegans models of human neurodegenerative diseases in vivo."3.85Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation. ( Alla, R; Ayyadevara, S; Balasubramaniam, M; Kakraba, S; Mehta, JL; Shmookler Reis, RJ, 2017)
"Collectively, these findings highlight the combination of Docosahexaenoic Acid and Aspirin as a possible measure against inflammation of the nervous system, thus leading to protection against neurodegenerative diseases with an inflammatory etiology."3.79Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin. ( Pettit, LK; Tadros, J; Varsanyi, C; Vassiliou, E, 2013)
"Both metformin and aspirin have been associated with improved cognitive outcomes."2.72AMPK activators for the prevention and treatment of neurodegenerative diseases. ( Neumann, NR; Thompson, DC; Vasiliou, V, 2021)
"With aspirin there is a 1."2.42[Prevention of cardiovascular and degenerative diseases: I. Aspirin, statins, or vitamins?]. ( Martin-Du Pan, RC, 2003)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's6 (75.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Neumann, NR1
Thompson, DC1
Vasiliou, V1
Ayyadevara, S1
Balasubramaniam, M1
Kakraba, S1
Alla, R1
Mehta, JL1
Shmookler Reis, RJ1
Yi, X2
Zhou, Q2
Wang, C2
Lin, J2
Chai, Z1
Ryan, JC1
Cross, CA1
Van Dolah, FM1
Wang, F1
Zhai, H1
Huang, L1
Li, H1
Xu, Y1
Qiao, X1
Sun, S1
Wu, Y1
Pettit, LK1
Varsanyi, C1
Tadros, J1
Vassiliou, E1
Martin-Du Pan, RC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Safety of Tirofiban in Patients With Acute Branch Atheromatous Disease (BAD)- Related Stroke (BRANT)[NCT06037889]Phase 3516 participants (Anticipated)Interventional2023-11-09Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for aspirin and Degenerative Diseases, Central Nervous System

ArticleYear
AMPK activators for the prevention and treatment of neurodegenerative diseases.
    Expert opinion on drug metabolism & toxicology, 2021, Volume: 17, Issue:10

    Topics: AMP-Activated Protein Kinases; Animals; Aspirin; Enzyme Activators; Humans; Metformin; Momordica cha

2021
[Prevention of cardiovascular and degenerative diseases: I. Aspirin, statins, or vitamins?].
    Revue medicale de la Suisse romande, 2003, Volume: 123, Issue:3

    Topics: Anticholesteremic Agents; Aspirin; Cardiovascular Diseases; Humans; Neurodegenerative Diseases; Vita

2003

Trials

1 trial available for aspirin and Degenerative Diseases, Central Nervous System

ArticleYear
Aspirin plus clopidogrel may reduce the risk of early neurologic deterioration in ischemic stroke patients carrying CYP2C19*2 reduced-function alleles.
    Journal of neurology, 2018, Volume: 265, Issue:10

    Topics: Aged; Aspirin; Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Fem

2018

Other Studies

5 other studies available for aspirin and Degenerative Diseases, Central Nervous System

ArticleYear
Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation.
    Antioxidants & redox signaling, 2017, Dec-10, Volume: 27, Issue:17

    Topics: Acetylation; Animals; Aspirin; Caenorhabditis elegans; Cell Line; Disease Models, Animal; Humans; Mo

2017
Interaction among COX-2, P2Y1 and GPIIIa gene variants is associated with aspirin resistance and early neurological deterioration in Chinese stroke patients.
    BMC neurology, 2017, Jan-09, Volume: 17, Issue:1

    Topics: Aged; Asian People; Aspirin; China; Cyclooxygenase 1; Cyclooxygenase 2; Drug Resistance; Female; Gen

2017
Effects of COX inhibitors on neurodegeneration and survival in mice exposed to the marine neurotoxin domoic acid.
    Neuroscience letters, 2011, Jan-03, Volume: 487, Issue:1

    Topics: Animals; Aspirin; Cell Survival; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Administrat

2011
Aspirin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity in primary midbrain cultures.
    Journal of molecular neuroscience : MN, 2012, Volume: 46, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Astrocytes; Coculture Techniques; Dopamin

2012
Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin.
    Lipids in health and disease, 2013, Feb-11, Volume: 12

    Topics: Anti-Inflammatory Agents; Aspirin; Cells, Cultured; Docosahexaenoic Acids; Glutathione; Humans; Infl

2013