aspirin and Curling Ulcer studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Curling Ulcer: Acute stress DUODENAL ULCER, usually observed in patients with extensive third-degree burns.

Research Excerpts

Excerpt	Relevance	Reference
"Lansoprazole was superior to gefarnate in reducing the risk of gastric or duodenal ulcer recurrence in patients with a definite history of gastric or duodenal ulcers who required long-term LDA therapy."	9.15	Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial. ( Abe, S; Ashida, K; Chiba, T; Hiramatsu, N; Itabashi, T; Kanto, T; Matsui, S; Matsumoto, Y; Mizokami, Y; Sakaki, N; Shimada, K; Sugano, K; Uchiyama, S; Uemura, N, 2011)
"A lower incidence of gastric and duodenal ulcers was seen in celecoxib/aspirin-treated subjects (19%) vs."	9.12	The impact of low-dose aspirin on endoscopic gastric and duodenal ulcer rates in users of a non-selective non-steroidal anti-inflammatory drug or a cyclo-oxygenase-2-selective inhibitor. ( Dodge, WE; Goldstein, JL; Lanza, FL; Lowry, SC; Schwartz, HI, 2006)
"Healing with bFGF (and cimetidine) was associated with reduced NSAID induced ulcer relapse in this model of gastric ulceration."	9.08	Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration. ( Brough, JL; Filipowicz, B; Hawkey, CJ; Hull, MA; Knifton, A; Vautier, G, 1997)
"Aspirin is commonly accepted as a risk factor for gastric ulcer; however, there is little published evidence linking aspirin consumption to duodenal ulcer."	9.06	The effect of chronic aspirin use on duodenal and gastric ulcer hospitalizations. ( Abbey, DE; Kurata, JH, 1990)
"To assess the associations of low-dose aspirin with gastric and duodenal ulcer incidence in prevalent- and new-user design."	8.12	Strongly increased risk of gastric and duodenal ulcers among new users of low-dose aspirin: results from two large cohorts with new-user design. ( Brenner, H; Chen, LJ; Holleczek, B; Nguyen, TNM; Schöttker, B; Sha, S, 2022)
"Long-term administration of low-dose aspirin (LDA) is associated with a greater risk of adverse events, including gastroduodenal ulcers."	7.79	Low-dose aspirin-associated upper gastric and duodenal ulcers in Japanese patients with no previous history of peptic ulcers. ( Funaki, Y; Iida, A; Ito, Y; Kasugai, K; Kawamura, N; Mizuno, M; Ogasawara, N; Sasaki, M, 2013)
"Endoscopy reveals low-dose aspirin-induced gastroduodenal injuries in patients with cerebral infarction."	7.76	Investigation of gastroduodenal mucosal injuries caused by low-dose aspirin therapy in patients with cerebral infarction. ( Kato, M; Nema, H, 2010)
" Optimal effective dose of PPSM (25 mg/kg) showed antiulcerogenic activity against acute gastric ulcers (GU) induced by pylorus ligation and aspirin and duodenal ulcer induced by cysteamine but not against ethanol-induced GU."	7.75	Effect of methanolic extract of Pongamia pinnata Linn seed on gastro-duodenal ulceration and mucosal offensive and defensive factors in rats. ( Agarwal, PK; Dorababu, M; Goel, RK; Goel, S; Joshi, VK; Prabha, T; Singh, A, 2009)
"Gastroduodenal ulcers are found in one in 10 patients taking low-dose aspirin, and most are asymptomatic; this needs considering when discussing risks/benefits with patients."	7.73	Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. ( Appelman-Eszczuk, S; Daneshjoo, R; Eriksson, B; Hawkey, CJ; Lanas, AI; Långström, G; Naesdal, J; Serrano, P; Singh, M; Skelly, MM; Talley, NJ; Thomson, AB; Yeomans, ND, 2005)
"The effect of cromakalim, a potassium-channel opener, was studied on pylorus ligation-induced, aspirin-induced and water-immersion plus restraint stress-induced gastric ulcers in rats and on histamine-induced duodenal ulcer in guinea-pigs."	7.69	Anti-ulcer activity of cromakalim (BRL 34915), a potassium-channel opener, against experimentally induced gastric and duodenal ulcers in rats and guinea-pigs. ( Goswami, S; Jain, S; Santani, D, 1997)
"The effects of omeprazole, a proton pump inhibitor, on gastric secretion and gastric or duodenal ulcers or erosions in rats were studied."	7.67	Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats. ( Okabe, S; Okada, Y; Yamamoto, O, 1984)
"Fifty-six patients who presented with non-steroidal anti-inflammatory drug-associated duodenal ulcers received maintenance treatment with ranitidine."	7.67	Ranitidine maintenance treatment of non-steroidal anti-inflammatory drug-induced duodenal ulceration. ( Penston, JG; Wormsley, KG, 1989)
"The distribution of mucosal PGE2-like activity was determined by bioassay technique in the body and antrum of the stomach and in the duodenum of healthy subjects and duodenal ulcer patients before and after administration of aspirin, paracetamol, or histamine."	7.66	Distribution of prostaglandins in gastric and duodenal mucosa of healthy subjects and duodenal ulcer patients: effects of aspirin and paracetamol. ( Kiec-Dembinska, A; Konturek, SJ; Obtulowicz, W; Oleksy, J; Sito, E; Wilkon, S, 1981)
"The effects of cimetidine, a new histamine H2-receptor antagonist, on the development of experimental gastric and duodenal ulcers were studied."	7.65	Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. ( Okabe, S; Takagi, K; Takeuchi, K; Urushidani, T, 1977)
" It is concluded that aspirin concurrently administered with ranitidine is safe and does not delay the healing of uncomplicated duodenal ulcers."	6.67	Aspirin concurrently administered with ranitidine does not delay healing of duodenal ulcer. ( Anand, BS; Kumar, N; Misra, SP, 1990)
"The rate of gastric ulcers in subjects receiving paracetamol (0/21, 0%) alone or aspirin (3/19, 16%) or both (2/20, 10%) was not different."	5.16	Does concomitant use of paracetamol potentiate the gastroduodenal mucosal injury associated with aspirin? A prospective, randomised, pilot study. ( Berkes, J; Boike, JR; Goldstein, JL; Kao, R; Markle, B; Meyer, D; Niebruegge, J; Rosenberg, J; Stein, AC, 2012)
"Lansoprazole was superior to gefarnate in reducing the risk of gastric or duodenal ulcer recurrence in patients with a definite history of gastric or duodenal ulcers who required long-term LDA therapy."	5.15	Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial. ( Abe, S; Ashida, K; Chiba, T; Hiramatsu, N; Itabashi, T; Kanto, T; Matsui, S; Matsumoto, Y; Mizokami, Y; Sakaki, N; Shimada, K; Sugano, K; Uchiyama, S; Uemura, N, 2011)
"To determine the rate of endoscopic gastric/duodenal ulcers (GDUs) associated with use of aspirin (81 mg q."	5.13	Endoscopic ulcer rates in healthy subjects associated with use of aspirin (81 mg q.d.) alone or coadministered with celecoxib or naproxen: a randomized, 1-week trial. ( Aisenberg, J; Berger, MF; Dodge, WE; Goldstein, JL; Zakko, SF, 2008)
"A lower incidence of gastric and duodenal ulcers was seen in celecoxib/aspirin-treated subjects (19%) vs."	5.12	The impact of low-dose aspirin on endoscopic gastric and duodenal ulcer rates in users of a non-selective non-steroidal anti-inflammatory drug or a cyclo-oxygenase-2-selective inhibitor. ( Dodge, WE; Goldstein, JL; Lanza, FL; Lowry, SC; Schwartz, HI, 2006)
"Subjects 18 years or older with osteoarthritis, without gastroduodenal ulcer or erosive esophagitis at baseline endoscopy, and a cardiovascular indication for prophylaxis low-dose (81 or 325 mg) aspirin were prescribed open-label aspirin and blindly randomized to celecoxib 200 mg/day or naproxen 500 mg twice daily plus lansoprazole 30 mg once daily."	5.12	Celecoxib plus aspirin versus naproxen and lansoprazole plus aspirin: a randomized, double-blind, endoscopic trial. ( Amer, F; Cryer, B; Goldstein, JL; Hunt, B, 2007)
"In this subgroup analysis in patients at high risk for recurrence of gastric ulcer, use of cotherapy with misoprostol 200 microg QID or lansoprazole 15 or 30 mg OD significantly lowered the risk for gastric ulcer recurrence."	5.11	Ulcer recurrence in high-risk patients receiving nonsteroidalanti-inflammatory drugs plus low-dose aspirin: results of a post HOC subanalysis. ( Amer, F; Christopoulos, NG; Goldstein, JL; Huang, B, 2004)
"Healing with bFGF (and cimetidine) was associated with reduced NSAID induced ulcer relapse in this model of gastric ulceration."	5.08	Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration. ( Brough, JL; Filipowicz, B; Hawkey, CJ; Hull, MA; Knifton, A; Vautier, G, 1997)
"Aspirin is commonly accepted as a risk factor for gastric ulcer; however, there is little published evidence linking aspirin consumption to duodenal ulcer."	5.06	The effect of chronic aspirin use on duodenal and gastric ulcer hospitalizations. ( Abbey, DE; Kurata, JH, 1990)
"Aspirin, even at low doses, has been known to cause upper gastro-intestinal complications, such as gastroduodenal ulcers, despite the definite benefits from its antithrombotic effects."	4.91	Geographic differences in low-dose aspirin-associated gastroduodenal mucosal injury. ( Iijima, K; Shimosegawa, T, 2015)
"Although figures vary considerably, the ingestion of aspirin or other non-aspirin non-steroidal anti-inflammatory drugs is associated with an increased risk of gastric ulceration, ulcer bleeding, ulcer complications and of death by a factor of around 3."	4.79	Nonsteroidal anti-inflammatory drug-induced gastric damage: epidemiology. ( Langman, MJ; Shorrock, CJ, 1995)
" Epidermal growth factor prevents efficiently the experimentally induced acute gastric mucosal lesions induced by aspirin, absolute ethanol, HCl, NaCl, immobilization, and immersion and it accelerates the healing of acetic acid-induced chronic gastric and cysteamine-induced chronic duodenal ulcers."	4.79	[Growth factors in experimental ulcer]. ( Buzás, G, 1994)
"A substantial body of studies (controlled, cohort and case-control studies) now confirm the long established impression that there is an increased prevalence of gastric and duodenal ulcer and of associated complications in subjects treated with aspirin (ASA) or with non-steroidal anti-inflammatory drugs (NSAIDs)."	4.79	[The epidemiology of the gastroduodenal damage induced by aspirin and other nonsteroidal anti-inflammatory drugs]. ( Benvenuti, S; de Guelmi, A; Dobrilla, G, 1997)
" Aspirin and all nonsalicylate NSAIDs share a risk of causing gastric ulcer, upper GI bleeding, and GI perforation."	4.78	Cost-conscious prescribing of nonsteroidal anti-inflammatory drugs for adults with arthritis. A review and suggestions. ( Greene, JM; Winickoff, RN, 1992)
" We counted and trended reports to FAERS in which aspirin was associated with anaphylaxis or anaphylaxis followed by death."	4.12	Analysis of Adverse Reactions of Aspirin in Prophylaxis Medication Based on FAERS Database. ( Guo, Y; Ren, W; Wang, W, 2022)
"To assess the associations of low-dose aspirin with gastric and duodenal ulcer incidence in prevalent- and new-user design."	4.12	Strongly increased risk of gastric and duodenal ulcers among new users of low-dose aspirin: results from two large cohorts with new-user design. ( Brenner, H; Chen, LJ; Holleczek, B; Nguyen, TNM; Schöttker, B; Sha, S, 2022)
"Long-term administration of low-dose aspirin (LDA) is associated with a greater risk of adverse events, including gastroduodenal ulcers."	3.79	Low-dose aspirin-associated upper gastric and duodenal ulcers in Japanese patients with no previous history of peptic ulcers. ( Funaki, Y; Iida, A; Ito, Y; Kasugai, K; Kawamura, N; Mizuno, M; Ogasawara, N; Sasaki, M, 2013)
"Advanced age, atherosclerosis, male gender and NSAID administration (particularly aspirin) are the major risk factors of upper GI hemorrhage in patients with gastric and/or duodenal ulcer."	3.77	Atherosclerosis and acetylsalicylic acid are independent risk factors for hemorrhage in patients with gastric or duodenal ulcer. ( Akkız, H; Coşar, A; Ozdil, B; Sandıkçı, M, 2011)
" Anti-ulcer activity was evaluated against cold restraint (CRU), pyloric ligation (PL), aspirin (ASP), alcohol (AL) induced gastric ulcer and histamine (HA) induced duodenal ulcer model and further confirmed through in vitro assay of H(+) K(+)-ATPase activity and plasma gastrin level."	3.77	Anti-ulcer constituents of Annona squamosa twigs. ( Dev, K; Maurya, R; Palit, G; Sahai, M; Sharma, R; Singh, N; Yadav, DK, 2011)
"Endoscopy reveals low-dose aspirin-induced gastroduodenal injuries in patients with cerebral infarction."	3.76	Investigation of gastroduodenal mucosal injuries caused by low-dose aspirin therapy in patients with cerebral infarction. ( Kato, M; Nema, H, 2010)
" Optimal effective dose of PPSM (25 mg/kg) showed antiulcerogenic activity against acute gastric ulcers (GU) induced by pylorus ligation and aspirin and duodenal ulcer induced by cysteamine but not against ethanol-induced GU."	3.75	Effect of methanolic extract of Pongamia pinnata Linn seed on gastro-duodenal ulceration and mucosal offensive and defensive factors in rats. ( Agarwal, PK; Dorababu, M; Goel, RK; Goel, S; Joshi, VK; Prabha, T; Singh, A, 2009)
"We present the case of a patient taking aspirin and etoricoxib who was admitted with upper digestive haemorrhage due to duodenal ulcer."	3.75	Low-dose aspirin reduces gastro-protective properties of COX-2 selective inhibitors. ( Soares, J, 2009)
"The present study was designed to investigate anti-ulcerogenic property of ethanolic extract of Desmodium gangeticum (DG) against cold restraint (CRU, 2 hr cold restraint stress), aspirin (ASP, 150 mg/kg orally), alcohol (AL, absolute alcohol 1 ml/200gm) and pyloric ligation (PL, 4 hr pylorus ligation) induced gastric ulcer models in Sprague Dawley rats, and histamine (HST, 0."	3.73	Desmodium gangeticum: a potent anti-ulcer agent. ( Chauhan, VS; Dharmani, P; Maurya, R; Mishra, PK; Palit, G, 2005)
"Gastroduodenal ulcers are found in one in 10 patients taking low-dose aspirin, and most are asymptomatic; this needs considering when discussing risks/benefits with patients."	3.73	Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. ( Appelman-Eszczuk, S; Daneshjoo, R; Eriksson, B; Hawkey, CJ; Lanas, AI; Långström, G; Naesdal, J; Serrano, P; Singh, M; Skelly, MM; Talley, NJ; Thomson, AB; Yeomans, ND, 2005)
"Erosive oesophagitis is common in patients with upper gastrointestinal bleeding taking low-dose aspirin or antithrombotic agents, and could potentially be confused with the coexisting heart disease."	3.73	Upper gastrointestinal mucosal abnormalities and blood loss complicating low-dose aspirin and antithrombotic therapy. ( Angerson, WJ; Blatchford, O; Knill-Jones, RP; Taha, AS, 2006)
" We evaluated its anti-ulcerogenic activity in cold restraint (CRU), aspirin (ASP), alcohol (AL), pyloric ligation (PL) induced gastric ulcer models in Sprague-Dawley rats, histamine-induced duodenal (HST) ulcer in guinea pigs, and ulcer-healing activity, in acetic acid-induced (AC) chronic ulcer model."	3.72	Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn. ( Dharmani, P; Kuchibhotla, VK; Maurya, R; Palit, G; Sharma, S; Srivastava, S, 2004)
"Gastric ulcers were induced in normal/NIDDM rats by various physical (2 hr cold restraint stress and 4 hr pylorus ligation) and chemical agents (ethanol, 1 ml/200 g, oral, 1 hr before; aspirin, 200 mg/kg, oral, 4 hr) and duodenal ulcers were induced by cysteamine (40 mg/200 g)."	3.72	Effect of Bacopa monniera and Azadirachta indica on gastric ulceration and healing in experimental NIDDM rats. ( Agrawal, VK; Aryya, NC; Dorababu, M; Goel, RK; Prabha, T; Priyambada, S, 2004)
" Ulcer score was calculated for cysteamine-induced duodenal ulcer model."	3.72	Biochemical studies on the anti-ulcerogenic potential of Hemidesmus indicus R.Br. var. indicus. ( Anoop, A; Jegadeesan, M, 2003)
" (BMJ) commonly known as Brahmi in Hindi was examined using gastric ulcer models induced by ethanol, aspirin, 2 h cold restraint stress and 4 h pylorus ligation."	3.70	Experimental evaluation of Bocopa monniera on rat gastric ulceration and secretion. ( Goel, RK; Rao, CV; Sairam, K, 2000)
"The effect of cromakalim, a potassium-channel opener, was studied on pylorus ligation-induced, aspirin-induced and water-immersion plus restraint stress-induced gastric ulcers in rats and on histamine-induced duodenal ulcer in guinea-pigs."	3.69	Anti-ulcer activity of cromakalim (BRL 34915), a potassium-channel opener, against experimentally induced gastric and duodenal ulcers in rats and guinea-pigs. ( Goswami, S; Jain, S; Santani, D, 1997)
" Z-103 given orally prevented development of gastric lesions induced by water immersion stress, histamine, HCl-aspirin, HCl-ethanol and also duodenal ulcers induced by mepirizole in a dose-dependent manner."	3.68	[Studies on anti-ulcer effects of a new compound, zinc L-carnosine (Z-103)]. ( Aita, H; Hori, Y; Morita, H; Okabe, S; Seiki, M; Soeda, M; Tagashira, E; Tanaka, Y; Ueki, S; Yoneta, T, 1990)
"A case-control study was performed to determine whether aspirin confers a similar risk of bleeding from gastric or duodenal ulcers in the elderly as non-aspirin, non-steroidal anti-inflammatory drugs."	3.67	Aspirin and bleeding peptic ulcers in the elderly. ( Faulkner, G; Langman, MJ; Prichard, P; Somerville, K, 1988)
"The purposes of this study were to determine whether inhibition of cyclooxygenase is a mechanism by which cysteamine and mepirizole produce duodenal ulcers, identify qualitative or quantitative differences in prostanoid production between gastric mucosa and duodenum, and determine whether differences in cyclooxygenase sensitivity to inhibition by aspirin exist between these two tissues."	3.67	Role of prostanoids in experimental duodenal ulcer in rat. ( Kauffman, GL; Kolve, E; Mangus, J; Walfisch, S, 1988)
"Fifty-six patients who presented with non-steroidal anti-inflammatory drug-associated duodenal ulcers received maintenance treatment with ranitidine."	3.67	Ranitidine maintenance treatment of non-steroidal anti-inflammatory drug-induced duodenal ulceration. ( Penston, JG; Wormsley, KG, 1989)
"The effects of omeprazole, a proton pump inhibitor, on gastric secretion and gastric or duodenal ulcers or erosions in rats were studied."	3.67	Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats. ( Okabe, S; Okada, Y; Yamamoto, O, 1984)
" Oral or intraduodenal administration of AG 629 in a dose range of 25-100 mg/kg inhibited water-immersion stress ulcer, exertion ulcer, Shay ulcer, indometacin- and acetylsalicylic acid (ASA)-induced gastric ulcer, and indomethacin-induced small intestinal ulcer in rats, histamine-induced gastric ulcer in guinea pigs, and ASA-induced gastric ulcer in dogs, though it was not effective against cysteamine-induced duodenal ulcer in rats."	3.67	Effects of 5-acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one, a new anti-ulcer agent, on experimental acute and chronic ulcers. ( Hirata, T; Inada, I; Inatomi, N; Maki, Y; Satoh, H; Sino, A, 1985)
"This study shows that human fundic mucosa generates various PGs, particularly PGE2, and thromboxanes and this generation appears to be significantly lower in gastric ulcer than in duodenal ulcer patients or normal subjects."	3.67	Prostaglandins in peptic ulcer disease: effect of nonsteroidal anti-inflammatory compounds (NOSAC). ( Konturek, SJ; Kopp, B; Kwiecień, N; Obtułowicz, W; Oleksy, J; Sito, E, 1984)
"Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear."	3.67	Peptic ulcer and non-steroidal anti-inflammatory agents. ( Dobson, AJ; Duggan, JM; Fahey, P; Johnson, H, 1986)
") inhibited the development of gastric ulcers induced by pylorus ligation, water-immersion stress, aspirin and reserpine and duodenal ulcers induced by cysteamine in rats."	3.67	Effect of elcatonin on experimental gastric and duodenal ulcers. ( Noguchi, M; Ohno, H; Takayanagi, N, 1985)
"The distribution of mucosal PGE2-like activity was determined by bioassay technique in the body and antrum of the stomach and in the duodenum of healthy subjects and duodenal ulcer patients before and after administration of aspirin, paracetamol, or histamine."	3.66	Distribution of prostaglandins in gastric and duodenal mucosa of healthy subjects and duodenal ulcer patients: effects of aspirin and paracetamol. ( Kiec-Dembinska, A; Konturek, SJ; Obtulowicz, W; Oleksy, J; Sito, E; Wilkon, S, 1981)
" However, SM powder had no effect on water-immersion stress- or aspirin-induced gastric lesions and mepirizole-induced duodenal ulcers."	3.66	[Effects of SM powder, a combined herbal preparation for stomach diseases, on gastric secretion and acute gastro-duodenal lesions in rats]. ( Ikenishi, H; Ohmi, F; Okabe, S; Takaoka, A; Takeuchi, K, 1983)
"The effects of a stable prostaglandin (PG) E2 analog (15-R-15 methyl PGE2) and aspirin, a potent inhibitor of cyclooxygenase, on modified sham-feeding (MSF)-stimulated gastric secretion and serum gastrin and pancreatic polypeptide (PP) levels were measured in patients with duodenal ulcer."	3.66	Prostaglandins and vagal stimulation of gastric secretion in duodenal ulcer patients. ( Konturek, SJ; Kwiecień, N; Obtułowicz, W; Oleksy, J, 1983)
"The effects of cimetidine, a new histamine H2-receptor antagonist, on the development of experimental gastric and duodenal ulcers were studied."	3.65	Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. ( Okabe, S; Takagi, K; Takeuchi, K; Urushidani, T, 1977)
"Rabeprazole prevents the recurrence of peptic ulcers with no evidence of a major dose-response effect in subjects on low-dose aspirin therapy."	2.79	Randomised clinical trial: prevention of recurrence of peptic ulcers by rabeprazole in patients taking low-dose aspirin. ( Arakawa, T; Fujimoto, K; Fujishiro, M; Higuchi, K; Iwakiri, R; Kato, M; Kinoshita, Y; Nakagawa, H; Ogawa, H; Okada, Y; Sanomura, M; Sugisaki, N; Takeuchi, T; Watanabe, T; Yamauchi, M, 2014)
"pylori gastritis was present than when it was absent, despite similar degrees of gastric mucosal prostaglandin depletion."	2.70	Role of Helicobacter pylori infection in gastroduodenal injury and gastric prostaglandin synthesis during long term/low dose aspirin therapy: a prospective placebo-controlled, double-blind randomized trial. ( Cryer, B; Feldman, M; Go, MF; Mallat, D, 2001)
"Gastric ulcers were noted in eight subjects in the aspirin group, one in the placebo group, and none in the risedronate group (P=0."	2.69	Placebo-controlled, randomized, evaluator-blinded endoscopy study of risedronate vs. aspirin in healthy postmenopausal women. ( Blank, MA; Krajewski, SA; Lanza, FL; Li, Z; Rack, MF, 2000)
" It is concluded that aspirin concurrently administered with ranitidine is safe and does not delay the healing of uncomplicated duodenal ulcers."	2.67	Aspirin concurrently administered with ranitidine does not delay healing of duodenal ulcer. ( Anand, BS; Kumar, N; Misra, SP, 1990)
"Misoprostol is a synthetic prostaglandin E1 analogue that inhibits gastric acid production and may augment mucosal defense."	2.66	Misoprostol reduces gastroduodenal injury from one week of aspirin: an endoscopic study. ( Jiranek, GC; Kimmey, MB; Saunders, DR; Shanahan, W; Silverstein, FE; Willson, RA, 1989)
" The introduction of new classes of drugs has resulted in new adverse effects that require consideration in patients presenting with gastroenterological symptoms."	2.43	Drug-induced side effects affecting the gastrointestinal tract. ( Chan, FK; Leong, RW, 2006)
"Chronic gastric ulcer is linked to aspirin intake in patients with rheumatic disease, and epidemiologically in all heavy aspirin users; paradoxically, in only one epidemiologic study was a significant association found between acetaminophen intake and chronic gastric ulcer."	2.36	Gastrointestinal effects of antipyretic analgesics. ( Ivey, KJ, 1983)
"With aspirin, however, it has long been believed that it is difficult to induce any damage in the intestinal mucosa of laboratory animals."	1.36	New method of inducing intestinal lesions in rats by intraduodenal administration of aspirin. ( Amagase, K; Nakagawa, K; Nakamura, M; Nonoyama, K; Okabe, S; Takeuchi, K, 2010)
"Gastric ulcer was detected in 12 subjects (six H."	1.36	Impact of upper gastrointestinal lesions in patients on low-dose aspirin therapy: preliminary study. ( Kawai, T; Watanabe, M; Yamashina, A, 2010)
"Gastroduodenal ulcers were found in 19 of 101 (18."	1.35	Endoscopic survey of low-dose-aspirin-induced gastroduodenal mucosal injuries in patients with ischemic heart disease. ( Asaka, M; Kato, M; Katsurada, T; Kawai, Y; Nema, H; Nozaki, Y; Okusa, T; Sakurai, M; Sato, K; Takagi, Y; Takiguchi, S; Yoshida, I; Yotsukura, A, 2008)
"In addition, diverticular bleeding in the elderly was highly associated with intake of Aspirin."	1.33	[Epidemiology of gastrointestinal bleeding in the elderly]. ( Bertschinger, P; Bühler, H; Geyer, M; Stamenic, I, 2006)
"Aspirin was associated with higher risk of upper gastrointestinal bleeding: OR=1."	1.31	[Upper gastrointestinal bleeding in patients treated by low-dose aspirin]. ( Amouretti, M; Capet, C; Colin, R; Czernichow, P; Dupas, JL; Goria, O; Gouérou, H; Herman, H; Hochain, P, 2001)
"Indomethacin (5 mg/kg) was given subcutaneously as a single dose and followed by multiple injections of histamine."	1.31	Protective effect of the nitric oxide donor molsidomine on indomethacin and aspirin-induced gastric injury in rats. ( Khuri, M; Mourad, FH; Nassar, CF; Shouaib, F, 2000)
" These lesions are mostly seen in patients with chronic use of nonsteroidal antiinflammatory drugs."	1.29	Duodenal diaphragmlike stricture induced by acetylsalicylic acid. ( Blinder, GH; Hautekeete, ML; Holvoet, JP; Hubens, HK; Kockx, MM, 1994)
"(4) Aspirin in 1% CMC was given to 10 rats of each group with the dose of 300 mg/kg body-weight."	1.28	[Influence of sucrose on aspirin ulcer]. ( Fujii, A; Okuma, K, 1989)
"Stress gastritis was present in 10% of patients, all of whom were in the intensive care unit."	1.27	Endoscopic diagnosis of gastritis: causative factors in 100 patients. ( Behler, E; Elta, G; Nostrant, T; Wilson, J, 1987)
"Aspirin alone was the least frequently ingested."	1.26	Analgesic ingestion and chronic peptic ulcer. ( Ariotti, DE; Fenton, BH; MacLennan, R; McIntosh, JH; Piper, DW, 1981)
" Duodenal mucosal injury, with or without gastric lesions, related to long-term use of anti-inflammatory drugs such as aspirin, indomethacin, ibuprofen, diclofenac or others are reported in three patients, in which the diagnosis was confirmed by emergency endoscopy after hematemesis."	1.26	Duodenal mucosal damage associated with chronic use of anti-inflammatory drugs. ( Ikeda, S; Tanaka, M; Uchiyama, M, 1977)
"One hundred consecutive cases of upper gastrointestinal hemorrhage were studied clinically, radiologically and endoscopically."	1.26	Upper gastrointestinal hemorrhage clinical, radiological and endoscopic correlation of 100 consecutive cases. ( Dinoso, VP; Lorber, SH; Meshkinpour, H, 1976)

Research

Studies (195)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Clostridium Difficile Diarrhea

Timeframe	Studies, this research(%)	All Research%
pre-1990	92 (47.18)	18.7374
1990's	31 (15.90)	18.2507
2000's	44 (22.56)	29.6817
2010's	24 (12.31)	24.3611
2020's	4 (2.05)	2.80

Authors	Studies
Nguyen, TNM	1
Sha, S	1
Chen, LJ	1
Holleczek, B	1
Brenner, H	1
Schöttker, B	1
Ren, W	1
Wang, W	1
Guo, Y	1
Yeomans, ND	2
Yang, HJ	1
Kawasaki, K	1
Nakamura, S	1
Kurahara, K	1
Nagasue, T	1
Yanai, S	1
Harada, A	1
Yaita, H	1
Fuchigami, T	1
Matsumoto, T	1
Taha, AS	2
McCloskey, C	1
McSkimming, P	1
McConnachie, A	1
Kogan, A	1
Tu, SW	1
Peleg, M	1
Sakaki, N	2
Ashida, K	2
Mizokami, Y	2
Chiba, T	2
Matsui, S	2
Kanto, T	2
Uemura, N	2
Hiramatsu, N	2
Sugano, K	2
Mousavi, M	1
Salehimarzijarani, B	1
Dadvar, Z	1
Jalalay, NY	1
Valizadeh, N	1
Sotoudeh, H	1
Zali, M	1
Kawamura, N	1
Ito, Y	1
Sasaki, M	1
Iida, A	1
Mizuno, M	2
Ogasawara, N	1
Funaki, Y	1
Kasugai, K	1
Iwakiri, R	2
Higuchi, K	1
Kato, M	3
Fujishiro, M	1
Kinoshita, Y	1
Watanabe, T	1
Takeuchi, T	1
Yamauchi, M	1
Sanomura, M	1
Nakagawa, H	1
Sugisaki, N	1
Okada, Y	2
Ogawa, H	1
Arakawa, T	1
Fujimoto, K	2
Howden, CW	1
Kwiecień, S	1
Magierowska, K	1
Śliwowski, Z	1
Wójcik, D	1
Magierowski, M	1
Brzozowski, T	1
Iijima, K	1
Shimosegawa, T	1
Cho, JH	1
Choi, JS	1
Chun, SW	1
Lee, S	1
Han, KJ	1
Kim, HM	1
Kanbayashi, Y	1
Konishi, H	1
Goldstein, JL	6
Scheiman, JM	1
Fort, JG	1
Whellan, DJ	1
Venerito, M	1
Treiber, G	1
Wex, T	1
Kuester, D	1
Roessner, A	1
Mönkemüller, K	1
Malfertheiner, P	1
Massó González, EL	1
García Rodríguez, LA	2
Sarkar, S	1
Buha, D	1
Nema, H	2
Katsurada, T	1
Nozaki, Y	1
Yotsukura, A	1
Yoshida, I	1
Sato, K	1
Kawai, Y	1
Takagi, Y	1
Okusa, T	1
Takiguchi, S	1
Sakurai, M	1
Asaka, M	1
Vestergård, A	1
Bredahl, K	1
de Muckadell, OB	1
Pedersen, OB	1
Hansen, JM	1
Dai, X	1
Makaryus, AN	1
Makaryus, JN	1
Jauhar, R	1
Prabha, T	2
Dorababu, M	2
Goel, S	1
Agarwal, PK	1
Singh, A	1
Joshi, VK	1
Goel, RK	3
Soares, J	1
Chen, TS	1
Luo, JC	1
Chang, FY	1
Nonoyama, K	1
Nakagawa, K	1
Amagase, K	1
Takeuchi, K	4
Nakamura, M	1
Okabe, S	8
Kawai, T	1
Watanabe, M	1
Yamashina, A	1
Ozdil, B	1
Coşar, A	1
Akkız, H	1
Sandıkçı, M	1
Yadav, DK	1
Singh, N	1
Dev, K	1
Sharma, R	1
Sahai, M	1
Palit, G	3
Maurya, R	3
Matsumoto, Y	1
Itabashi, T	1
Abe, S	1
Shimada, K	1
Uchiyama, S	1
Fujimori, S	1
Sakamoto, C	1
Shiotani, A	1
Manabe, N	1
Kamada, T	1
Fujimura, Y	1
Sakakibara, T	1
Haruma, K	1
Boike, JR	1
Kao, R	1
Meyer, D	1
Markle, B	1
Rosenberg, J	1
Niebruegge, J	1
Stein, AC	1
Berkes, J	1
Reed, S	1
Anoop, A	1
Jegadeesan, M	1
Shostak, NA	1
Riabkova, AA	1
Savel'ev, VS	1
Maliarova, LP	1
PLASS, HF	1
MENGUY, R	2
BUSSON, A	2
BOURDON, R	2
BARD, M	2
BISMUTH, V	2
LANGMAN, MJ	3
HANSKY, JH	1
DRURY, RA	1
JONES, FA	1
JENNINGS, GH	1
Hirschowitz, BI	1
Brandt, K	1
Sibilia, J	1
Ravaud, P	1
Marck, G	1
Jayaprakash, A	1
McGrath, C	1
McCullagh, E	1
Smith, F	1
Angelini, G	1
Probert, C	1
Priyambada, S	1
Agrawal, VK	1
Aryya, NC	1
Rao, ChV	1
Ojha, SK	1
Radhakrishnan, K	1
Govindarajan, R	1
Rastogi, S	1
Mehrotra, S	1
Pushpangadan, P	1
Tanaka, J	1
Iida, H	1
Abe, M	1
Yuda, Y	1
Inoue, S	1
Dharmani, P	2
Kuchibhotla, VK	1
Srivastava, S	1
Sharma, S	2
Devi, DP	1
Sushma, M	1
Guido, S	1
Huang, B	1
Amer, F	2
Christopoulos, NG	1
Arkkila, PE	1
Seppälä, K	1
Kosunen, TU	1
Sipponen, P	1
Mäkinen, J	1
Rautelin, H	1
Färkkilä, M	1
Niv, Y	1
Battler, A	1
Abuksis, G	1
Gal, E	1
Sapoznikov, B	1
Vilkin, A	1
Mishra, PK	1
Chauhan, VS	1
Lanas, AI	1
Talley, NJ	1
Thomson, AB	1
Daneshjoo, R	1
Eriksson, B	1
Appelman-Eszczuk, S	1
Långström, G	1
Naesdal, J	1
Serrano, P	1
Singh, M	1
Skelly, MM	1
Hawkey, CJ	5
Angerson, WJ	1
Knill-Jones, RP	1
Blatchford, O	1
Vallurupalli, NG	1
Goldhaber, SZ	1
Lowry, SC	1
Lanza, FL	4
Schwartz, HI	1
Dodge, WE	2
Geyer, M	1
Stamenic, I	1
Bühler, H	1
Bertschinger, P	1
Leong, RW	1
Chan, FK	1
Ribeiro, AQ	1
Sevalho, G	1
César, CC	1
Yilmaz, S	1
Bayan, K	1
Dursun, M	1
Canoruç, F	1
Kilinç, N	1
Tüzün, Y	1
Daniş, R	1
Ertem, M	1
Barreales Tolosa, L	1
Aisenberg, J	1
Zakko, SF	1
Berger, MF	1
Cryer, B	2
Hunt, B	1
Ishikawa, S	1
Inaba, T	1
Okada, H	1
Kuwaki, K	1
Kuzume, T	1
Yokota, H	1
Fukuda, Y	1
Takeda, K	1
Nagano, H	1
Wato, M	1
Kawai, K	1
O'Brien, WM	1
Ivey, KJ	3
Konturek, SJ	3
Kwiecień, N	2
Obtułowicz, W	2
Oleksy, J	3
Chiu, PJ	1
Barnett, A	1
Gerhart, C	1
Policelli, M	1
Kaminski, J	1
Sito, E	2
Kopp, B	1
Bruseghini, L	1
Basi, N	1
Gras, J	1
Llenas, J	1
de Miguel, G	1
Rodés, B	1
Sanfeliu, C	1
Vilageliu, J	1
Zapatero, J	1
Giraldez, A	1
Yamamoto, O	1
Desai, HG	1
Zaveri, MP	1
Kalro, RH	1
Ikenishi, H	1
Ohmi, F	1
Takaoka, A	1
Lockard, OO	1
Butt, JH	1
Silvoso, GR	2
Sisk, C	1
Holt, S	1
Protell, RL	1
Silverstein, FE	2
Gilbert, DA	1
Feld, AD	1
O'Laughlin, JC	1
Obtulowicz, W	1
Wilkon, S	1
Kiec-Dembinska, A	1
Scheibe, O	1
Piper, DW	2
McIntosh, JH	1
Ariotti, DE	1
Fenton, BH	1
MacLennan, R	1
Hochain, P	2
Berkelmans, I	1
Czernichow, P	2
Duhamel, C	1
Tranvouez, JL	1
Lerebours, E	1
Colin, R	2
Shorrock, CJ	1
Moulin, C	1
Bosson, JL	1
Rolachon, A	1
Li, V	1
Cohard, M	1
Girard, M	1
Hostein, J	1
Buzás, G	1
Sekiguchi, H	1
Hamada, K	1
Taga, F	1
Nishino, K	1
Blinder, GH	1
Hautekeete, ML	2
Holvoet, JP	1
Kockx, MM	1
Hubens, HK	1
Oren, R	1
Ligumsky, M	1
Lysy, J	2
Gonzales, J	1
Zimmerman, J	2
Terashima, K	1
Shimamura, H	1
Kawase, A	1
Tanaka, Y	2
Tanimura, T	1
Kamisaki, T	1
Ishizuka, Y	1
Sato, M	1
McAlindon, ME	1
Muller, AF	1
Filipowicz, B	3
Atherton, JC	2
Peek, RM	1
Tham, KT	1
Cover, TL	1
Blaser, MJ	1
Goswami, S	1
Jain, S	1
Santani, D	1
Hull, MA	1
Knifton, A	1
Brough, JL	1
Vautier, G	1
Prach, AT	1
Senior, BW	1
Hopwood, D	1
McBride, PD	1
MacDonald, TM	1
Kerr, MA	1
Murray, FE	1
Dobrilla, G	1
Benvenuti, S	1
de Guelmi, A	1
Rack, MF	2
Simon, TJ	1
Quan, H	1
Bolognese, JA	1
Hoover, ME	1
Wilson, FR	1
Harper, SE	1
Kaufman, DW	1
Kelly, JP	1
Wiholm, BE	1
Laszlo, A	1
Sheehan, JE	1
Koff, RS	1
Shapiro, S	1
Mourad, FH	1
Khuri, M	1
Shouaib, F	1
Nassar, CF	1
Donnelly, MT	1
Goddard, AF	1
Morant, SV	1
Shield, MJ	1
Li, Z	1
Krajewski, SA	1
Blank, MA	1
Rao, CV	1
Sairam, K	1
Capet, C	1
Dupas, JL	1
Goria, O	1
Gouérou, H	1
Amouretti, M	1
Herman, H	1
Feldman, M	1
Mallat, D	1
Go, MF	1
Stack, WA	1
Hawkey, GM	1
Logan, RF	1
Builder, J	1
Landecker, K	1
Whitecross, D	1
Urushidani, T	1
Takagi, K	2
Sogge, MR	1
Griffith, JL	1
Sinar, DR	1
Mayes, GR	1
Sicot, C	1
Tolot, F	1
Prost, G	1
Guignot, B	1
Pelletier, M	1
Graham, DY	2
Davis, RE	1
Baccaro, JC	1
González, BA	1
Cupula, CA	1
Oddsson, E	1
Binder, V	1
Thorgeirsson, T	1
Jonasson, TA	1
Gunnlaugsson, O	1
Wulff, M	1
Jónasson, K	1
Wulff, HR	1
Bjarnason, O	1
Riis, P	1
Lewis, EA	1
Aderoju, EA	1
Dorofeev, GI	1
Ivashkin, VT	1
Kuznetsov, VV	1
Tkachenko, EI	1
Duggan, JM	8
Goodman, MJ	1
Kent, PW	1
Truelove, SC	1
Tanaka, M	1
Uchiyama, M	1
Ikeda, S	1
Meshkinpour, H	1
Dinoso, VP	1
Lorber, SH	1
Buckingham, JM	1
Remine, WH	1
Greene, JM	1
Winickoff, RN	1
Arnon, R	1
Beeri, R	1
Keret, D	1
Ligumski, M	1
Gonzalez, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Misoprostol for the Healing of Small Bowel Ulceration in Patients With Obscure Blood Loss While Taking Low-dose Aspirin or Nonsteroidal Antiinflammatory Drugs [MASTERS Trial][NCT02202967]	Phase 3	104 participants (Actual)	Interventional	2016-01-07	Completed
Optimal Dose of Proton Pump Inhibitors Following an Upper Gastrointestinal Bleed[NCT02235311]		3 participants (Actual)	Interventional	2014-10-31	Terminated (stopped due to Difficulty recruiting and consenting participants)
European Registry on the Management of Helicobacter Pylori Infection[NCT02328131]		10,000 participants (Anticipated)	Observational	2013-06-30	Recruiting
Does Acetaminophen Potentiate the Gastroduodenal Mucosal Injury of Aspirin? A Prospective, Randomized, Pilot Study.[NCT00594867]	Phase 4	94 participants (Actual)	Interventional	2006-12-31	Completed
A Randomized, Double-Blind, Phase 3 Study to Compare the Efficacy and Safety of Lansoprazole 30 mg QD and Naproxen 500 mg BID Versus Celecoxib 200 mg QD in Risk Reduction of Non Steroidal Anti-Inflammatory-Associated Ulcers in Osteoarthritis Subjects Taki[NCT00175032]	Phase 3	1,045 participants (Actual)	Interventional	2003-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Clostridium difficile confirmed by polymerase chain reaction (PCR) (NCT02235311)
Timeframe: 8 weeks

Community-Acquired Pneumonia

Intervention	Participants (Count of Participants)
Pantoprazole Twice Daily	0
Pantoprazole Once Daily	0

As defined by clinical suspicion and/or positive sputum culture requiring antibiotic treatment (NCT02235311)
Timeframe: 8 weeks

Rate of Rebleed

Intervention	Participants (Count of Participants)
Pantoprazole Twice Daily	0
Pantoprazole Once Daily	0

"Per patient report or as defined by follow-up endoscopy per gastroenterology service, 8 weeks after UGIB acute management~High clinical suspicion of rebleed includes melena, hematochezia, confirmed by repeat endoscopy, requiring additional management" (NCT02235311)
Timeframe: 8 weeks

Ulcer Healing

Intervention	Participants (Count of Participants)
Pantoprazole Twice Daily	0
Pantoprazole Once Daily	0

as defined by follow-up endoscopy per gastroenterology service, 8 weeks after UGIB acute management (NCT02235311)
Timeframe: 8 weeks

Article	Year
Management of Peptic Ulcer Bleeding in Patients Taking Aspirin or Anticoagulant. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2020, 11-25, Volume: 76, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Duodenal Ulcer; Helicobacter Infec	2020
New insight into the mechanisms of gastroduodenal injury induced by nonsteroidal anti-inflammatory drugs: practical implications. Polskie Archiwum Medycyny Wewnetrznej, 2015, Volume: 125, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Duodenal Ulcer; Gastric	2015
Geographic differences in low-dose aspirin-associated gastroduodenal mucosal injury. World journal of gastroenterology, 2015, Jul-07, Volume: 21, Issue:25 Topics: Anti-Inflammatory Agents, Non-Steroidal; Asia; Aspirin; Australia; Duodenal Ulcer; Duodenum; Europe;	2015
Significant gastrointestinal bleeding in patients at risk of coronary stent thrombosis. Reviews in cardiovascular medicine, 2009,Winter, Volume: 10, Issue:1 Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Anti-Bacterial Agents; Aspirin; Clopidogrel; Coro	2009
[Actual status and vision of NSAIDs-induced intestinal injuries]. Nihon rinsho. Japanese journal of clinical medicine, 2011, Volume: 69, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Humans; Intestinal Diseases; Intes	2011
Risk and preventive factors of low-dose aspirin-induced gastroduodenal injuries: a comprehensive review. Journal of gastroenterology and hepatology, 2012, Volume: 27 Suppl 3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Duodena	2012
CURRENT CONCEPTS OF THE ETIOLOGY OF DUODENAL ULCER. The American journal of digestive diseases, 1964, Volume: 9 Topics: Adrenal Cortex Hormones; Aspirin; Caffeine; Duodenal Ulcer; Gastric Juice; Gastric Mucosa; Genetics,	1964
Usual and unusual causes of duodenal ulcer. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2003, Volume: 35, Issue:8 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Helicobacter Infections; Helicobac	2003
[Paracetamol in the treatment of osteoarthritis pain]. Drugs, 2003, Volume: 63 Spec No 2 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg	2003
[Digestive and hemorrhage complications of low-dose aspirin]. Presse medicale (Paris, France : 1983), 2003, Nov-22, Volume: 32, Issue:37 Pt 2 Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Co	2003
Gastrointestinal complications of dual antiplatelet therapy. Circulation, 2006, Mar-28, Volume: 113, Issue:12 Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Duodenal Ulcer; Endoscopy,	2006
Drug-induced side effects affecting the gastrointestinal tract. Expert opinion on drug safety, 2006, Volume: 5, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bone Density Conservation Agents; Colitis; Colon;	2006
Pharmacology of nonsteroidal anti-inflammatory drugs. Practical review for clinicians. The American journal of medicine, 1983, Oct-31, Volume: 75, Issue:4B Topics: Animals; Anti-Inflammatory Agents; Aspirin; Digestive System; Drug Evaluation, Preclinical; Duodenal	1983
Gastrointestinal effects of antipyretic analgesics. The American journal of medicine, 1983, Nov-14, Volume: 75, Issue:5A Topics: Acetaminophen; Adenosine Triphosphate; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bicarbonate	1983
Nonsteroidal anti-inflammatory drug-induced gastric damage: epidemiology. Digestive diseases (Basel, Switzerland), 1995, Volume: 13 Suppl 1 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Humans; M	1995
[Growth factors in experimental ulcer]. Orvosi hetilap, 1994, Dec-11, Volume: 135, Issue:50 Topics: Animals; Aspirin; Chronic Disease; Duodenal Ulcer; Epidermal Growth Factor; Ethanol; Fibroblast Grow	1994
[The epidemiology of the gastroduodenal damage induced by aspirin and other nonsteroidal anti-inflammatory drugs]. Recenti progressi in medicina, 1997, Volume: 88, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Duodenum; Gastric Mucosa; Humans;	1997
[Digestive complications of corticoid treatment]. La Revue du praticien, 1975, Mar-11, Volume: 25, Issue:15 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aspirin; Colonic Diseases; Duodenal Ulcer; Eso	1975
Progress report. Aspirin in chronic gastric ulcer: an Australian experience. Gut, 1976, Volume: 17, Issue:5 Topics: Aspirin; Australia; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Peptic Ulcer Hemorrhage; Self	1976
Cost-conscious prescribing of nonsteroidal anti-inflammatory drugs for adults with arthritis. A review and suggestions. Archives of internal medicine, 1992, Volume: 152, Issue:10 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Aspirin; Clinical Prot	1992
Experimental pathogenesis: drugs and chemical lesions in the gastric mucosa. Scandinavian journal of gastroenterology. Supplement, 1990, Volume: 174 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Ethanol; Gastric Mucosa;	1990
[Effects of gastric proton pump inhibitors on gastric secretion and peptic ulcers]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1986, Volume: 87, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Aspi	1986
Mechanisms of mucosal injury in the stomach and duodenum: time-sequence analysis of morphologic, functional, biochemical and histochemical studies. Scandinavian journal of gastroenterology. Supplement, 1987, Volume: 127 Topics: Animals; Aspirin; Duodenal Ulcer; Duodenum; Ethanol; Gastric Mucosa; Humans; Intestinal Mucosa; Rats	1987
What's new in steroid and nonsteroid drug effects on gastroduodenal mucosa? Pathology, research and practice, 1985, Volume: 180, Issue:4 Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Aspirin; Duodenal Ulcer; Duodenum; Gastr	1985
[Effect of some drugs in the development and exacerbation of gastric and duodenal ulcer]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1974, Jun-15, Volume: 27, Issue:12 Topics: Adrenocorticotropic Hormone; Aspirin; Caffeine; Catecholamines; Duodenal Ulcer; Fluorouracil; Glucoc	1974
[Effect of some antirheumatic agents on the gastric mucous membrane]. Klinicheskaia meditsina, 1971, Volume: 49, Issue:8 Topics: Adrenocorticotropic Hormone; Aged; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis, Rheuma	1971
Gastrointestinal hemorrhage. I. General considerations of diagnosis and the rapy. Advances in surgery, 1973, Volume: 7 Topics: Anus Diseases; Aspirin; Biliary Tract Diseases; Blood Coagulation Disorders; Burns; Child; Child, Pr	1973
Etiology of peptic ulcer. The Practitioner, 1974, Volume: 213, Issue:1273 Topics: Anxiety Disorders; Aspirin; Bile Acids and Salts; Blood Group Antigens; Diet; Duodenal Ulcer; Female	1974
[Modern views on peptic ulcers]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1970, Nov-01, Volume: 23, Issue:21 Topics: Alcohols; Aspirin; Duodenal Ulcer; Female; Gastric Mucosa; Gastrins; Humans; Male; Parasympatholytic	1970

Article	Year
Misoprostol for small bowel ulcers in patients with obscure bleeding taking aspirin and non-steroidal anti-inflammatory drugs (MASTERS): a randomised, double-blind, placebo-controlled, phase 3 trial. The lancet. Gastroenterology & hepatology, 2018, Volume: 3, Issue:7 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Capsule Endoscopy; Double	2018
Endoscopic evaluation of low-dose aspirin-induced gastric and duodenal ulcers during prophylaxis with lansoprazole. Hepato-gastroenterology, 2013, Volume: 60, Issue:124 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Comorbidity; Double-Blind	2013
Randomised clinical trial: prevention of recurrence of peptic ulcers by rabeprazole in patients taking low-dose aspirin. Alimentary pharmacology & therapeutics, 2014, Volume: 40, Issue:7 Topics: Aged; Anti-Ulcer Agents; Aspirin; Double-Blind Method; Duodenal Ulcer; Female; Fibrinolytic Agents;	2014
Aspirin Use in Secondary Cardiovascular Protection and the Development of Aspirin-Associated Erosions and Ulcers. Journal of cardiovascular pharmacology, 2016, Volume: 68, Issue:2 Topics: Adolescent; Adult; Aspirin; Cardiovascular Agents; Cardiovascular Diseases; Disease Progression; Dou	2016
Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial. Journal of gastroenterology, 2011, Volume: 46, Issue:6 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Ulcer Agents; Aspirin; Double-Blind Method; Duod	2011
Does concomitant use of paracetamol potentiate the gastroduodenal mucosal injury associated with aspirin? A prospective, randomised, pilot study. Alimentary pharmacology & therapeutics, 2012, Volume: 36, Issue:4 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster	2012
Ulcer recurrence in high-risk patients receiving nonsteroidalanti-inflammatory drugs plus low-dose aspirin: results of a post HOC subanalysis. Clinical therapeutics, 2004, Volume: 26, Issue:10 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, N	2004
Helicobacter pylori eradication as the sole treatment for gastric and duodenal ulcers. European journal of gastroenterology & hepatology, 2005, Volume: 17, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agent	2005
The impact of low-dose aspirin on endoscopic gastric and duodenal ulcer rates in users of a non-selective non-steroidal anti-inflammatory drug or a cyclo-oxygenase-2-selective inhibitor. Alimentary pharmacology & therapeutics, 2006, May-15, Volume: 23, Issue:10 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Doub	2006
Does adding misoprostol to standard intravenous proton pump inhibitor protocol improve the outcome of aspirin/NSAID-induced upper gastrointestinal bleeding?: a randomized prospective study. Digestive diseases and sciences, 2007, Volume: 52, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer A	2007
Endoscopic ulcer rates in healthy subjects associated with use of aspirin (81 mg q.d.) alone or coadministered with celecoxib or naproxen: a randomized, 1-week trial. Digestive diseases and sciences, 2008, Volume: 53, Issue:3 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Double-Blind Method; Drug Therapy	2008
Celecoxib plus aspirin versus naproxen and lansoprazole plus aspirin: a randomized, double-blind, endoscopic trial. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2007, Volume: 5, Issue:10 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovas	2007
Effect of allopurinol, sulphasalazine, and vitamin C on aspirin induced gastroduodenal injury in human volunteers. Gut, 1996, Volume: 38, Issue:4 Topics: Adult; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Ascorb	1996
Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration. Gut, 1997, Volume: 40, Issue:2 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cimetidine; Cross-Over S	1997
Specific inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen. Alimentary pharmacology & therapeutics, 1999, Volume: 13, Issue:6 Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenas	1999
Low-dose misoprostol for the prevention of low-dose aspirin-induced gastroduodenal injury. Alimentary pharmacology & therapeutics, 2000, Volume: 14, Issue:5 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Double-Blind Method; Duo	2000
Placebo-controlled, randomized, evaluator-blinded endoscopy study of risedronate vs. aspirin in healthy postmenopausal women. Alimentary pharmacology & therapeutics, 2000, Volume: 14, Issue:12 Topics: Adult; Aged; Aspirin; Duodenal Ulcer; Endoscopy, Gastrointestinal; Esophagus; Etidronic Acid; Female	2000
Role of Helicobacter pylori infection in gastroduodenal injury and gastric prostaglandin synthesis during long term/low dose aspirin therapy: a prospective placebo-controlled, double-blind randomized trial. The American journal of gastroenterology, 2001, Volume: 96, Issue:6 Topics: Adolescent; Adult; Antibodies, Bacterial; Aspirin; Blood Platelets; Cyclooxygenase 1; Double-Blind M	2001
Upper gastrointestinal bleeding in relation to previous use of analgesics and non-steroidal anti-inflammatory drugs. Catalan Countries Study on Upper Gastrointestinal Bleeding. Lancet (London, England), 1991, Jan-12, Volume: 337, Issue:8733 Topics: Adult; Age Factors; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control	1991
Relation of upper gastrointestinal bleeding to non-steroidal anti-inflammatory drugs and aspirin: a case-control study. Gut, 1991, Volume: 32, Issue:7 Topics: Adolescent; Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control	1991
Effect of Helicobacter pylori infection on the severity of gastroduodenal mucosal injury after the acute administration of naproxen or aspirin to normal volunteers. The American journal of gastroenterology, 1991, Volume: 86, Issue:6 Topics: Adult; Aspirin; Duodenal Ulcer; Duodenum; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Helic	1991
The effect of chronic aspirin use on duodenal and gastric ulcer hospitalizations. Journal of clinical gastroenterology, 1990, Volume: 12, Issue:3 Topics: Adult; Aged; Aspirin; Double-Blind Method; Duodenal Ulcer; Female; Follow-Up Studies; Hospitalizatio	1990
Aspirin concurrently administered with ranitidine does not delay healing of duodenal ulcer. Australian and New Zealand journal of medicine, 1990, Volume: 20, Issue:3 Topics: Adult; Aspirin; Drug Therapy, Combination; Duodenal Ulcer; Duodenoscopy; Female; Humans; Male; Ranit	1990
Misoprostol reduces gastroduodenal injury from one week of aspirin: an endoscopic study. Gastroenterology, 1989, Volume: 96, Issue:2 Pt 2 Sup Topics: Adolescent; Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Clinical Trials as Topic; Double-Blind M	1989
[Stomach tolerance of nonsteroidal antirheumatic drugs: comparative endoscopic study]. Zeitschrift fur Rheumatologie, 1987, Volume: 46 Suppl 1 Topics: Adult; Alprostadil; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspiri	1987

Article	Year
Strongly increased risk of gastric and duodenal ulcers among new users of low-dose aspirin: results from two large cohorts with new-user design. Alimentary pharmacology & therapeutics, 2022, Volume: 56, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Gastrointestinal Hemorrhage; Human	2022
Analysis of Adverse Reactions of Aspirin in Prophylaxis Medication Based on FAERS Database. Computational and mathematical methods in medicine, 2022, Volume: 2022 Topics: Adverse Drug Reaction Reporting Systems; Anaphylaxis; Aspirin; Duodenal Ulcer; Humans; Melena; Unite	2022
Editorial: risk of gastric and duodenal ulcers among new users of low-dose aspirin. Alimentary pharmacology & therapeutics, 2022, Volume: 56, Issue:2 Topics: Aspirin; Duodenal Ulcer; Humans; Stomach Ulcer	2022
Continuing use of antithrombotic medications for patients with bleeding gastroduodenal ulcer requiring endoscopic hemostasis: a case-control study. Scandinavian journal of gastroenterology, 2017, Volume: 52, Issue:9 Topics: Aged; Aged, 80 and over; Aspirin; Case-Control Studies; Duodenal Ulcer; Duodenum; Female; Fibrinolyt	2017
Goal-driven management of interacting clinical guidelines for multimorbidity patients. AMIA ... Annual Symposium proceedings. AMIA Symposium, 2018, Volume: 2018 Topics: Algorithms; Aspirin; Cardiovascular Diseases; Decision Support Systems, Clinical; Duodenal Ulcer; Go	2018
Relationship between continuous use of low-dose enteric-coated aspirin and gastrointestinal injuries in patients with gastrointestinal hemorrhage. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2013, Volume: 24, Issue:2 Topics: Aspirin; Case-Control Studies; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Gastrointestinal	2013
Low-dose aspirin-associated upper gastric and duodenal ulcers in Japanese patients with no previous history of peptic ulcers. BMC research notes, 2013, Nov-12, Volume: 6 Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Asian People; Aspirin; Diabetes Complications; Diabetes	2013
PPI vs. teprenone in preventing recurrence of ulcers during low-dose aspirin - authors' reply. Alimentary pharmacology & therapeutics, 2014, Volume: 40, Issue:11-12 Topics: Anti-Ulcer Agents; Aspirin; Duodenal Ulcer; Female; Fibrinolytic Agents; Humans; Male; Rabeprazole;	2014
PPI vs. teprenone in preventing recurrence of ulcers during low-dose aspirin. Alimentary pharmacology & therapeutics, 2014, Volume: 40, Issue:11-12 Topics: Anti-Ulcer Agents; Aspirin; Duodenal Ulcer; Female; Fibrinolytic Agents; Humans; Male; Rabeprazole;	2014
The IL-1B Genetic Polymorphism Is Associated with Aspirin-Induced PepticUlcers in a Korean Ethnic Group. Gut and liver, 2016, May-23, Volume: 10, Issue:3 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Sectional Studies; Cyclooxygenase 1; D	2016
Predictive Factors for NSAIDs-related Gastrointestinal Toxicity: Can COX-2 Selective Inhibtor Prevent it?. Hepato-gastroenterology, 2015, Volume: 62, Issue:140 Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antineoplast	2015
Short-term/low-dose aspirin-induced duodenal erosions are not dependent on Helicobacter pylori infection, cyclooxygenase expression and prostaglandin E2 levels. Scandinavian journal of gastroenterology, 2008, Volume: 43, Issue:7 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Du	2008
Proton pump inhibitors reduce the long-term risk of recurrent upper gastrointestinal bleeding: an observational study. Alimentary pharmacology & therapeutics, 2008, Sep-01, Volume: 28, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin;	2008
Effect of ripe fruit pulp extract of Cucurbita pepo Linn. in aspirin induced gastric and duodenal ulcer in rats. Indian journal of experimental biology, 2008, Volume: 46, Issue:9 Topics: Animals; Anti-Ulcer Agents; Aspirin; Cucurbita; Duodenal Ulcer; Female; Fruit; Male; Plant Extracts;	2008
Endoscopic survey of low-dose-aspirin-induced gastroduodenal mucosal injuries in patients with ischemic heart disease. Journal of gastroenterology and hepatology, 2008, Volume: 23 Suppl 2 Topics: Aged; Aspirin; Case-Control Studies; Drug Administration Schedule; Duodenal Ulcer; Duodenoscopy; Fem	2008
[Bleeding peptic ulcer. Prevalence of Helicobacter pylori and use of nonsteroidal anti-inflammatory drugs/acetylsalicylic acid]. Ugeskrift for laeger, 2009, Jan-19, Volume: 171, Issue:4 Topics: Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Femal	2009
Effect of methanolic extract of Pongamia pinnata Linn seed on gastro-duodenal ulceration and mucosal offensive and defensive factors in rats. Indian journal of experimental biology, 2009, Volume: 47, Issue:8 Topics: Acetic Acid; Animals; Aspirin; Catalase; Chromatography, Thin Layer; Cold Temperature; Duodenal Ulce	2009
Low-dose aspirin reduces gastro-protective properties of COX-2 selective inhibitors. Clinical drug investigation, 2009, Volume: 29 Suppl 2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents;	2009
Prevalence of Helicobacter pylori infection in duodenal ulcer and gastro-duodenal ulcer diseases in Taiwan. Journal of gastroenterology and hepatology, 2010, Volume: 25, Issue:5 Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breath Tests;	2010
Investigation of gastroduodenal mucosal injuries caused by low-dose aspirin therapy in patients with cerebral infarction. Journal of gastroenterology and hepatology, 2010, Volume: 25 Suppl 1 Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Cardiovascular Agents; Cerebral Infarction; Chi	2010
New method of inducing intestinal lesions in rats by intraduodenal administration of aspirin. Journal of gastroenterology and hepatology, 2010, Volume: 25 Suppl 1 Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents;	2010
Impact of upper gastrointestinal lesions in patients on low-dose aspirin therapy: preliminary study. Journal of gastroenterology and hepatology, 2010, Volume: 25 Suppl 1 Topics: Aged; Aspirin; Cardiovascular Agents; Duodenal Ulcer; Endoscopy, Digestive System; Esophageal Neopla	2010
Atherosclerosis and acetylsalicylic acid are independent risk factors for hemorrhage in patients with gastric or duodenal ulcer. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2011, Volume: 11, Issue:1 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ather	2011
Anti-ulcer constituents of Annona squamosa twigs. Fitoterapia, 2011, Volume: 82, Issue:4 Topics: Animals; Annona; Anti-Ulcer Agents; Aporphines; Aspirin; Benzylisoquinolines; Berberine Alkaloids; C	2011
Nonsteroidal anti-inflammatory drug-induced duodenal ulceration and perforation in a mature rottweiler. The Canadian veterinary journal = La revue veterinaire canadienne, 2002, Volume: 43, Issue:12 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dog Diseases; Dogs; Duodenal Ulcer; Male;	2002
Biochemical studies on the anti-ulcerogenic potential of Hemidesmus indicus R.Br. var. indicus. Journal of ethnopharmacology, 2003, Volume: 84, Issue:2-3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Carbohydrate Metabolis	2003
[Gastrointestinal hemorrhages as complications of gastropathies associated with intake of nonsteroidal anti-inflammatory drugs]. Terapevticheskii arkhiv, 2003, Volume: 75, Issue:5 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Duodenal Ulcer; Duodeno	2003
RENAL PAPILLARY NECROSIS ASSOCIATED WITH ANALGESIC ABUSE. Annals of internal medicine, 1964, Volume: 60 Topics: Analgesics; Aspirin; Caffeine; Duodenal Ulcer; Humans; Kidney Papillary Necrosis; Phenacetin; Radiog	1964
[RADIO-CLINICAL ASPECTS OF MEDICAMENTOUS GASTRO-DUODENAL ULCERS]. Archives des maladies de l'appareil digestif et des maladies de la nutrition, 1964, Volume: 53 Topics: Aspirin; Cortisone; Duodenal Ulcer; Methylprednisolone; Peptic Ulcer; Phenylbutazone; Radiography; T	1964
[ETIOLOGY OF THE DUODENAL ULCER]. Munchener medizinische Wochenschrift (1950), 1964, Mar-27, Volume: 106 Topics: Aspirin; Caffeine; Disease Susceptibility; Duodenal Ulcer; Genetics, Medical; Humans; Hyperparathyro	1964
[RADIO-CLINICAL ASPECTS OF MEDICAMENTOUS GASTRO-DUODENAL ULCERS]. La Presse medicale, 1964, Oct-28, Volume: 72 Topics: Adrenal Cortex Hormones; Aspirin; Duodenal Ulcer; Humans; Peptic Ulcer; Phenylbutazone; Radiography;	1964
THE GASTRIC MUCOSA IN RADIOLOGICALLY NEGATIVE ACUTE GASTROINTESTINAL BLEEDING. Gut, 1964, Volume: 5 Topics: Aspirin; Biopsy; Duodenal Ulcer; Gastric Acidity Determination; Gastric Mucosa; Gastritis; Gastroint	1964
CAUSAL INFLUENCES IN HAEMATEMESIS AND MELAENA. Gut, 1965, Volume: 6 Topics: Alcoholic Beverages; Arteriosclerosis; Aspirin; Blood Group Antigens; Duodenal Ulcer; Genetics, Medi	1965
Upper gastrointestinal haemorrhage following cardiac surgery: a comparative study with vascular surgery patients from a single centre. European journal of gastroenterology & hepatology, 2004, Volume: 16, Issue:2 Topics: Aged; Aspirin; Cardiac Surgical Procedures; Coronary Artery Bypass; Duodenal Ulcer; Female; Gastroin	2004
Effect of Bacopa monniera and Azadirachta indica on gastric ulceration and healing in experimental NIDDM rats. Indian journal of experimental biology, 2004, Volume: 42, Issue:4 Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Aspirin; Azadirachta; Bacopa; Cold Temperature; Diabetes Me	2004
Antiulcer activity of Utleria salicifolia rhizome extract. Journal of ethnopharmacology, 2004, Volume: 91, Issue:2-3 Topics: Acetic Acid; Administration, Oral; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Dose-Response	2004
Gastric antisecretory and anti-ulcer effect of ME3407, a new benzimidazole derivative, in rats. Arzneimittel-Forschung, 2004, Volume: 54, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Cysteamine; Duodenal	2004
Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn. Journal of ethnopharmacology, 2004, Volume: 93, Issue:2-3 Topics: Animals; Anti-Ulcer Agents; Aspirin; Duodenal Ulcer; Ethanol; Female; Guinea Pigs; Histamine; Male;	2004
Drug-induced upper gastrointestinal disorders requiring hospitalization: a five-year study in a South Indian hospital. Pharmacoepidemiology and drug safety, 2004, Volume: 13, Issue:12 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug-Related Side Effects a	2004
Endoscopy in asymptomatic minidose aspirin consumers. Digestive diseases and sciences, 2005, Volume: 50, Issue:1 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationshi	2005
Desmodium gangeticum: a potent anti-ulcer agent. Indian journal of experimental biology, 2005, Volume: 43, Issue:6 Topics: Alcohols; Animals; Anti-Ulcer Agents; Aspirin; Cold Temperature; Duodenal Ulcer; Ethanol; Fabaceae;	2005
Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. Alimentary pharmacology & therapeutics, 2005, Nov-01, Volume: 22, Issue:9 Topics: Aged; Aspirin; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Humans; Incidence; Male; Middle	2005
Upper gastrointestinal mucosal abnormalities and blood loss complicating low-dose aspirin and antithrombotic therapy. Alimentary pharmacology & therapeutics, 2006, Feb-15, Volume: 23, Issue:4 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Clopidogrel; Dipyrida	2006
Upper gastrointestinal bleeding after hip and knee arthroplasty. Orthopedics, 2006, Volume: 29, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Arthroplast	2006
[Epidemiology of gastrointestinal bleeding in the elderly]. Praxis, 2006, May-10, Volume: 95, Issue:19 Topics: Age Factors; Aged; Aged, 80 and over; Angiodysplasia; Anti-Inflammatory Agents, Non-Steroidal; Aspir	2006
The use of nonsteroidal anti-inflammatory drugs and the occurrence of gastric lesions among patients undergoing upper endoscopy in a university hospital in Brazil. Clinics (Sao Paulo, Brazil), 2006, Volume: 61, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brazil; Confounding Factors, Epidemiologic; Diclof	2006
Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population. Gastroenterology, 2007, Volume: 132, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Anticoagulants; Aspirin; Case-Control St	2007
Incidence of serious upper gastrointestinal bleeding in patients taking non-steroidal anti-inflammatory drugs in Japan. Acta medica Okayama, 2008, Volume: 62, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Du	2008
Prostaglandins and vagal stimulation of gastric secretion in duodenal ulcer patients. Scandinavian journal of gastroenterology, 1983, Volume: 18, Issue:1 Topics: Adult; Arbaprostil; Aspirin; Duodenal Ulcer; Gastric Acid; Gastric Juice; Gastrins; Humans; Pepsin A	1983
Gastric cytoprotective properties of SCH 32651, a novel antiulcer agent. Archives internationales de pharmacodynamie et de therapie, 1984, Volume: 270, Issue:1 Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cysteamine; Drug Evaluation, Preclinical; Duoden	1984
Prostaglandins in peptic ulcer disease: effect of nonsteroidal anti-inflammatory compounds (NOSAC). Scandinavian journal of gastroenterology. Supplement, 1984, Volume: 92 Topics: Adult; Anti-Inflammatory Agents; Aspirin; Carbazoles; Duodenal Ulcer; Gastric Mucosa; Humans; Indome	1984
Anti-ulcer activity and other pharmacological properties of lozilurea. Arzneimittel-Forschung, 1983, Volume: 33, Issue:12 Topics: Animals; Anti-Ulcer Agents; Aspirin; Dogs; Duodenal Ulcer; Female; Gastric Mucosa; Guinea Pigs; Hexo	1983
Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats. Digestive diseases and sciences, 1984, Volume: 29, Issue:5 Topics: Animals; Aspirin; Benzimidazoles; Chemical Phenomena; Chemistry; Duodenal Ulcer; Epirizole; Gastric	1984
Comparison of the effect of ordinary and microfined aspirin on the DNA content of gastric aspirates. The Indian journal of medical research, 1983, Volume: 77 Topics: Aspirin; DNA; Duodenal Ulcer; Gastric Mucosa; Gastritis; Humans; Particle Size	1983
[Effects of SM powder, a combined herbal preparation for stomach diseases, on gastric secretion and acute gastro-duodenal lesions in rats]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1983, Volume: 81, Issue:4 Topics: Animals; Aspirin; Depression, Chemical; Duodenal Ulcer; Ethanol; Gastric Juice; Immersion; Indometha	1983
The prevalence of duodenal lesions in patients with rheumatic diseases on chronic aspirin therapy. Gastrointestinal endoscopy, 1980, Volume: 26, Issue:1 Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Buffers; Duodenal Diseases; Duodenal Ulcer; Endoscopy;	1980
Severe upper gastrointestinal bleeding. Part I: Causes, pathogenesis and methods of diagnosis. Clinics in gastroenterology, 1981, Volume: 10, Issue:1 Topics: Angiography; Aspirin; Duodenal Ulcer; Endoscopy; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans	1981
Healing of aspirin-associated peptic ulcer disease despite continued salicylate ingestion. Archives of internal medicine, 1981, Volume: 141, Issue:6 Topics: Adolescent; Adult; Aged; Antacids; Arthritis, Rheumatoid; Aspirin; Cimetidine; Duodenal Ulcer; Femal	1981
Distribution of prostaglandins in gastric and duodenal mucosa of healthy subjects and duodenal ulcer patients: effects of aspirin and paracetamol. Gut, 1981, Volume: 22, Issue:4 Topics: Acetaminophen; Adult; Aspirin; Duodenal Ulcer; Duodenum; Gastric Mucosa; Histamine; Humans; Intestin	1981
[The meaning of specialist and adequate documentation for retrospective analysis of sicknesses (author's transl)]. Langenbecks Archiv fur Chirurgie, 1981, Volume: 355 Topics: Aspirin; Documentation; Duodenal Ulcer; Humans; Postoperative Complications; Prospective Studies; Ra	1981
Analgesic ingestion and chronic peptic ulcer. Gastroenterology, 1981, Volume: 80, Issue:3 Topics: Acetaminophen; Analgesics; Aspirin; Australia; Duodenal Ulcer; Female; Humans; Male; Peptic Ulcer; R	1981
Which patients taking non-aspirin non-steroidal anti-inflammatory drugs bleed? A case-control study. European journal of gastroenterology & hepatology, 1995, Volume: 7, Issue:5 Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Alcoholism; Anti-Inflammatory Agents, Non-Steroida	1995
[Can early recurrent hemorrhage in gastroduodenal ulcer be predicted?]. Gastroenterologie clinique et biologique, 1994, Volume: 18, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; En	1994
Effects of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy]propyl] urea with potent gastric mucosal protective activity on acute gastric lesions and duodenal ulcers in rats. Arzneimittel-Forschung, 1993, Volume: 43, Issue:2 Topics: Animals; Anti-Ulcer Agents; Aspirin; Cyanides; Duodenal Ulcer; Epirizole; Ethanol; Gastric Mucosa; H	1993
Duodenal diaphragmlike stricture induced by acetylsalicylic acid. Digestive diseases and sciences, 1994, Volume: 39, Issue:6 Topics: Aspirin; Constriction, Pathologic; Duodenal Obstruction; Duodenal Ulcer; Humans; Male; Middle Aged	1994
Gastro-duodenal injury associated with intake of 100-325 mg aspirin daily. Postgraduate medical journal, 1993, Volume: 69, Issue:815 Topics: Acute Disease; Aged; Aged, 80 and over; Aspirin; Drug Administration Schedule; Duodenal Ulcer; Femal	1993
[The prophylactic taking of low doses of acetylsalicylic acid and the risk of ulcer hemorrhage]. Deutsche medizinische Wochenschrift (1946), 1995, Dec-15, Volume: 120, Issue:50 Topics: Aspirin; Dose-Response Relationship, Drug; Duodenal Ulcer; Humans; Middle Aged; Peptic Ulcer Hemorrh	1995
Studies on antiulcer agents. IV. Antiulcer effects of 2-benzylthio5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds. Chemical & pharmaceutical bulletin, 1995, Volume: 43, Issue:11 Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Duodenal Ulcer; Epirizole;	1995
Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology, 1997, Volume: 112, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atrophy; Bacterial	1997
Anti-ulcer activity of cromakalim (BRL 34915), a potassium-channel opener, against experimentally induced gastric and duodenal ulcers in rats and guinea-pigs. The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:2 Topics: Animals; Aspirin; Benzopyrans; Cromakalim; Duodenal Ulcer; Female; Guinea Pigs; Histamine; Male; Pot	1997
Helicobacter pylori infection status in relation to antibiotic and non-steroidal prescribing in patients on maintenance treatment for chronic duodenal ulcer. European journal of gastroenterology & hepatology, 1997, Volume: 9, Issue:3 Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy; Chroni	1997
The risk of acute major upper gastrointestinal bleeding among users of aspirin and ibuprofen at various levels of alcohol consumption. The American journal of gastroenterology, 1999, Volume: 94, Issue:11 Topics: Acute Disease; Aged; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Contro	1999
Protective effect of the nitric oxide donor molsidomine on indomethacin and aspirin-induced gastric injury in rats. European journal of gastroenterology & hepatology, 2000, Volume: 12, Issue:1 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Gas	2000
Experimental evaluation of Bocopa monniera on rat gastric ulceration and secretion. Indian journal of physiology and pharmacology, 2000, Volume: 44, Issue:4 Topics: Animals; Anti-Ulcer Agents; Aspirin; Central Nervous System Depressants; Cold Temperature; DNA; Duod	2000
[Upper gastrointestinal bleeding in patients treated by low-dose aspirin]. Gastroenterologie clinique et biologique, 2001, Volume: 25, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Duodenal Ulcer; Female; France; Gastrointestinal Hemorrhage	2001
Interactions between Helicobacter pylori and other risk factors for peptic ulcer bleeding. Alimentary pharmacology & therapeutics, 2002, Volume: 16, Issue:3 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Bacterial; Aspirin; Bacterial Protei	2002
Aspirin esterase of gastric mucosal origin. Gastroenterology, 1977, Volume: 73, Issue:1 Topics: Age Factors; Alcoholic Beverages; Aspirin; Drug Stability; Duodenal Ulcer; Esterases; Ethanol; Femal	1977
Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. The American journal of digestive diseases, 1977, Volume: 22, Issue:8 Topics: Administration, Oral; Animals; Aspirin; Carbachol; Depression, Chemical; Disease Models, Animal; Duo	1977
Lavage to remove enteric-coated aspirin and gastric outlet obstruction. Annals of internal medicine, 1977, Volume: 87, Issue:6 Topics: Aspirin; Bicarbonates; Duodenal Ulcer; Humans; Hydrogen-Ion Concentration; Ischemia; Male; Pyloric S	1977
[Multiple manifestations of intolerance of a combination of anti-inflammatory drugs. Role of phenylbutazone]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1975, Dec-09, Volume: 51, Issue:48 Topics: Anti-Inflammatory Agents; Aspirin; Chemical and Drug Induced Liver Injury; Duodenal Ulcer; Erythema;	1975
Acute upper-gastrointestinal hemorrhage. New observations on an old problem. The American journal of digestive diseases, 1978, Volume: 23, Issue:1 Topics: Alcohol Drinking; Aspirin; Duodenal Ulcer; Esophageal and Gastric Varices; Esophagoscopy; Gastritis;	1978
[Value of endoscopy in the diagnosis of upper digestive tract hemorrhage]. Acta gastroenterologica Latinoamericana, 1979, Volume: 9, Issue:4 Topics: Alcoholic Beverages; Aspirin; Critical Care; Duodenal Ulcer; Endoscopy; Esophageal Diseases; Gastroi	1979
A prospective comparative study of clinical and pathological characteristics in Icelandic and Danish patients with gastric ulcer, duodenal ulcer, and X-ray negative dyspepsia. II. Histological results. Scandinavian journal of gastroenterology, 1978, Volume: 13, Issue:4 Topics: Adult; Age Factors; Aged; Alcohol Drinking; Aspirin; Denmark; Duodenal Ulcer; Dyspepsia; Female; Gas	1978
Factors in the aetiology of chronic duodenal ulcer in Ibadan. Tropical and geographical medicine, 1978, Volume: 30, Issue:1 Topics: Adolescent; Adult; Aged; Alcohol Drinking; Aspirin; Child; Diet; Duodenal Ulcer; Female; Food; Human	1978
[Lactate dehydrogenase (LDH) activity of the gastric juice depending on the metabolic state and protective barrier of the gastric mucosa]. Terapevticheskii arkhiv, 1978, Volume: 50, Issue:10 Topics: Adult; Aspirin; Chronic Disease; Duodenal Ulcer; Enzyme Activation; Gastric Juice; Gastric Mucosa; G	1978
Inhibition of glucosamine synthesis by salicylates, hydrocortisone and two non-ulcerogenic drugs. Archives internationales de pharmacodynamie et de therapie, 1977, Volume: 226, Issue:1 Topics: Acetaminophen; Aspirin; Carbohydrate Epimerases; Duodenal Ulcer; Gastric Mucosa; Gentamicins; Glutam	1977
Duodenal mucosal damage associated with chronic use of anti-inflammatory drugs. Endoscopy, 1977, Volume: 9, Issue:3 Topics: Aged; Anti-Inflammatory Agents; Aspirin; Diclofenac; Duodenal Ulcer; Endoscopy; Female; Fiber Optic	1977
Upper gastrointestinal hemorrhage clinical, radiological and endoscopic correlation of 100 consecutive cases. Pahlavi medical journal, 1976, Volume: 7, Issue:4 Topics: Adult; Aged; Aspirin; Duodenal Ulcer; Endoscopy; Esophageal Diseases; Ethanol; Female; Gastritis; Ga	1976
Results of emergency surgical management of hemorrhagic duodenal ulcer. Mayo Clinic proceedings, 1975, Volume: 50, Issue:5 Topics: Adolescent; Adult; Aged; Aspirin; Duodenal Ulcer; Emergencies; Female; Gastrectomy; Gastroscopy; Hum	1975
Seasonal fluctuations in acute upper gastrointestinal bleeding: lack of effect of nonsteroidal anti-inflammatory drugs. The American journal of gastroenterology, 1992, Volume: 87, Issue:11 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Emergencies; Esophagitis; Gastriti	1992
Helicobacter pylori-negative duodenal ulcer. The American journal of medicine, 1991, Volume: 91, Issue:1 Topics: Aspirin; Chronic Disease; Duodenal Ulcer; Duodenoscopy; Female; Gastritis; Helicobacter Infections;	1991
Aspirin concurrently administered with ranitidine does not delay healing of duodenal ulcer. Australian and New Zealand journal of medicine, 1991, Volume: 21, Issue:1 Topics: Aspirin; Duodenal Ulcer; Humans; Ranitidine; Statistics as Topic	1991
Ethical aspects of a study of the effects of aspirin on the healing of duodenal ulcer. Australian and New Zealand journal of medicine, 1991, Volume: 21, Issue:1 Topics: Aspirin; Duodenal Ulcer; Ethics, Medical; Humans; Ranitidine; Wound Healing	1991
[Studies on anti-ulcer effects of a new compound, zinc L-carnosine (Z-103)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1990, Volume: 95, Issue:5 Topics: Animals; Anti-Ulcer Agents; Aspirin; Carnosine; Dogs; Duodenal Ulcer; Epirizole; Ethanol; Gastric Ac	1990
[The duodenum and non-steroidal anti-inflammatory agents]. Recenti progressi in medicina, 1990, Volume: 81, Issue:6 Topics: Adolescent; Adult; Aged; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer;	1990
Mucosal protective activity of activated aluminum complex. Digestion, 1990, Volume: 45, Issue:1 Topics: Aluminum Hydroxide; Animals; Antacids; Aspirin; Cysteamine; Duodenal Ulcer; Ethanol; Gastric Mucosa;	1990
[Influence of sucrose on aspirin ulcer]. Nichidai koku kagaku = Nihon University journal of oral science, 1989, Volume: 15, Issue:4 Topics: Animals; Aspirin; Drug Interactions; Duodenal Ulcer; Rats; Stomach Ulcer; Sucrose	1989
Ranitidine maintenance treatment of non-steroidal anti-inflammatory drug-induced duodenal ulceration. Alimentary pharmacology & therapeutics, 1989, Volume: 3, Issue:5 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Duodenal Ulcer; Du	1989
Peptic ulcer disease: physiology and pathophysiology. Hospital practice (Office ed.), 1985, Jan-15, Volume: 20, Issue:1 Topics: Antacids; Aspirin; Bismuth; Duodenal Ulcer; Gastric Acid; Gastric Mucosa; Histamine H2 Antagonists;	1985
Role of prostanoids in experimental duodenal ulcer in rat. Digestive diseases and sciences, 1988, Volume: 33, Issue:6 Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Cysteamine; Dose-Response Relationship, Drug; Duodenal	1988
Aspirin and bleeding peptic ulcers in the elderly. BMJ (Clinical research ed.), 1988, Nov-19, Volume: 297, Issue:6659 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Female; Humans; Male; Middle	1988
[Changes in stomach and duodenal mucosa caused by acetylsalicylic acid therapy]. Acta medica Austriaca, 1988, Volume: 15, Issue:3 Topics: Aspirin; Dose-Response Relationship, Drug; Duodenal Ulcer; Duodenum; Female; Gastric Mucosa; Humans;	1988
Endoscopic diagnosis of gastritis: causative factors in 100 patients. Southern medical journal, 1987, Volume: 80, Issue:9 Topics: Adult; Aged; Alcoholism; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Duodeniti	1987
Peptic ulcer and non-steroidal anti-inflammatory agents. Gut, 1986, Volume: 27, Issue:8 Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Aspirin; Duodenal Ulcer; Female; Humans; Male; Middle	1986
[The weakness of the gastric mucosa barrier: a new concept]. Gastroenterologie clinique et biologique, 1985, Volume: 9, Issue:12 Pt 2 Topics: Action Potentials; Adult; Aged; Antacids; Aspirin; Duodenal Ulcer; Ethanol; Female; Gastric Acidity	1985
S.E.M. study II: Protective effect of ranitidine against gastric and duodenal lesions induced by non-steroidal anti-inflammatory drugs. International journal of tissue reactions, 1986, Volume: 8, Issue:1 Topics: Adult; Anti-Inflammatory Agents; Aspirin; Duodenal Ulcer; Endoscopy; Female; Humans; Male; Microscop	1986
Effect of elcatonin on experimental gastric and duodenal ulcers. Japanese journal of pharmacology, 1985, Volume: 37, Issue:1 Topics: Acetates; Acetic Acid; Actihaemyl; Animals; Anti-Ulcer Agents; Aspirin; Calcitonin; Cimetidine; Cyst	1985
Effects of 5-acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one, a new anti-ulcer agent, on experimental acute and chronic ulcers. Arzneimittel-Forschung, 1985, Volume: 35, Issue:10 Topics: Acetates; Acetic Acid; Acute Disease; Animals; Anti-Ulcer Agents; Aspirin; Benzofurans; Chronic Dise	1985
Environmental factors and the Australian gastric ulcer change. The Medical journal of Australia, 1969, Jun-07, Volume: 1, Issue:23 Topics: Adrenal Cortex Hormones; Adult; Alcohol Drinking; Aspirin; Australia; Disabled Persons; Duodenal Ulc	1969
[Duodenal ulcer and accessory pancreatitis. Sever hemorrhage triggered off by contact with aspirin]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1970, May-20, Volume: 46, Issue:24 Topics: Aspirin; Duodenal Ulcer; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Pan	1970
The effect of some drugs on oxalic acid excretion in urine. Arzneimittel-Forschung, 1970, Volume: 20, Issue:2 Topics: Ascorbic Acid; Aspirin; Asthma; Calcium; Citrates; Coronary Disease; Depression, Chemical; Diabetes	1970
Effects of an antiulcer agent N-acetyl-L-glutamine aluminum complex (KW-110) on the duodenal and gastric ulcer models in the rat. Japanese journal of pharmacology, 1974, Volume: 24, Issue:3 Topics: Acetates; Aluminum; Animals; Aspirin; Atropine; Duodenal Ulcer; Glutamine; Male; Rats; Stomach Ulcer	1974
The natural history of duodenal ulceration. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1972, Apr-08, Volume: 46, Issue:15 Topics: Aspirin; Duodenal Ulcer; Female; Gastric Acidity Determination; Gastric Juice; Gastrointestinal Hemo	1972
Acute gastro-intestinal haemorrhage. Prognostic factors on a conservative regime. The Medical journal of Australia, 1972, Jul-22, Volume: 2, Issue:4 Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Aspirin; Australia; Child; Child, Preschool; Du	1972
[Ulcers of the gastroduodenal tract due to drugs. Apropos of a personal experience]. Acta gastro-enterologica Belgica, 1972, Volume: 35, Issue:9 Topics: Adrenal Cortex Hormones; Adult; Aged; Analgesics; Aspirin; Duodenal Ulcer; Female; Gastrointestinal	1972
The management of upper gastro-intestinal tract haemorrhage. The British journal of surgery, 1973, Volume: 60, Issue:4 Topics: Adolescent; Adult; Aged; Aortic Aneurysm; Aspirin; Carcinoma; Duodenal Ulcer; Esophageal and Gastric	1973
Epidemiology and course of gastrointestinal haemorrhage in North-east Scotland. British medical journal, 1973, Sep-29, Volume: 3, Issue:5882 Topics: Adult; Aged; Alcohol Drinking; Aspirin; Blood Group Antigens; Duodenal Ulcer; Female; Gastritis; Gas	1973
Aspirin use in patients with major upper gastrointestinal bleeding and peptic-ulcer disease. A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. The New England journal of medicine, 1974, May-23, Volume: 290, Issue:21 Topics: Adult; Aged; Aspirin; Boston; Drug Evaluation; Duodenal Ulcer; Female; Gastrointestinal Hemorrhage;	1974
[Gastro-duodenal tolerance of some drugs with analgesic effect. Clinico-endoscopic considerations]. Minerva medica, 1974, Feb-24, Volume: 65, Issue:14 Topics: Analgesics; Anti-Inflammatory Agents; Antimalarials; Aspirin; Digestive System; Duodenal Ulcer; Esop	1974
[Endoscopic diagnosis of acute medication (aspirin) ulcers of the duodenal bulb]. Sovetskaia meditsina, 1974, Volume: 0, Issue:4 Topics: Acute Disease; Adult; Aspirin; Chronic Disease; Duodenal Ulcer; Endoscopy; Gastrointestinal Hemorrha	1974
The management of a patient with a duodenal ulcer. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1972, Nov-25, Volume: 46, Issue:47 Topics: Adult; Alcohol Drinking; Alkalies; Aspirin; Chronic Disease; Diet Therapy; Duodenal Ulcer; Humans; P	1972
Injury and repair in acute gastroduodenal ulceration. American journal of surgery, 1973, Volume: 125, Issue:1 Topics: Acute Disease; Aspirin; Burns; Cushing Syndrome; Duodenal Ulcer; Gastric Mucosa; Humans; Infections;	1973
Gastric and duodenal ulceration associated with aspirin ingestion. Gastrointestinal endoscopy, 1973, Volume: 19, Issue:4 Topics: Adult; Aged; Aspirin; Duodenal Ulcer; Endoscopy; Female; Gastroscopy; Humans; Male; Middle Aged; Sto	1973
[Peptic ulcer hemorrhage due to anticoagulants]. Deutsche medizinische Wochenschrift (1946), 1973, Sep-14, Volume: 98, Issue:37 Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Blood Transfusion; Coumarins; Digitalis Glycosides; Do	1973
Upper gastrointestinal disease in rheumatoid arthritis. The American journal of digestive diseases, 1974, Volume: 19, Issue:5 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Arizona; Arthritis, Rheumatoid; Aspir	1974
Aspirin ingestion and perforated peptic ulcer. Gut, 1972, Volume: 13, Issue:8 Topics: Aspirin; Duodenal Ulcer; Female; Humans; Male; Peptic Ulcer Perforation; Sex Factors; Stomach Ulcer;	1972
ABO blood groups in gastric bleeding. Gut, 1966, Volume: 7, Issue:6 Topics: ABO Blood-Group System; Adult; Aspirin; Blood Group Antigens; Duodenal Ulcer; Female; Gastric Mucosa	1966
Lesions associated with gastroduodenal haemorrhage, in relation to aspirin intake. British medical journal, 1968, Dec-14, Volume: 4, Issue:5632 Topics: Adult; Aged; Aspirin; Duodenal Ulcer; Gastrointestinal Hemorrhage; Gastroscopy; Hematemesis; Humans;	1968
[Upper digestive hemorrhages in patients with gastroduodenal ulcer after administration of ulcerogenic drugs]. Medicina interna, 1969, Mar-03, Volume: 21, Issue:3 Topics: Adult; Aged; Aminopyrine; Aspirin; Duodenal Ulcer; Female; Humans; Hydrocortisone; Influenza, Human;	1969
Aspirin and alcohol in gastrointestinal haemorrhage. Gut, 1971, Volume: 12, Issue:10 Topics: Aspirin; Drug Synergism; Duodenal Ulcer; Esophageal and Gastric Varices; Ethanol; Female; Gastritis;	1971
Perforated peptic ulcer. The Medical journal of Australia, 1969, Oct-25, Volume: 2, Issue:17 Topics: Adult; Age Factors; Aspirin; Australia; Duodenal Ulcer; Female; Follow-Up Studies; Gastrectomy; Huma	1969
The incidence of aspirin ingestion in patients with peptic ulcer. The Medical journal of Australia, 1970, Apr-18, Volume: 1, Issue:16 Topics: Adolescent; Adult; Age Factors; Aged; Aspirin; Australia; Caffeine; Child; Duodenal Ulcer; Female; H	1970
[Psychiatric and gastroenterological evaluation of patients with duodenal ulcer confirmed at operation. 100 patients studied by preoperative psychiatric interview and enlarged histamine test with special reference to the relation between psychic factors a Nordisk medicin, 1970, Oct-29, Volume: 83, Issue:44 Topics: Adolescent; Adult; Age Factors; Aged; Alcohol Drinking; Aspirin; Character; Child; Drinking Behavior	1970
[Stenosing esophagitis, postbulbar duodenal ulcer and aspirin addiction]. Lyon medical, 1971, May-23, Volume: 225, Issue:10 Topics: Adult; Aspirin; Duodenal Ulcer; Esophageal Stenosis; Humans; Male; Substance-Related Disorders	1971
Aspirin-induced gastrointestinal lesions in dogs. Journal of the American Veterinary Medical Association, 1968, Mar-15, Volume: 152, Issue:6 Topics: Animals; Aspirin; Dog Diseases; Dogs; Duodenal Ulcer; Female; Gastrointestinal Diseases; Male; Stoma	1968
Gastric ulcer, duodenal ulcer and gastric carcinoma: a case-control study of certain social and environmental factors. The Medical journal of Australia, 1968, Dec-21, Volume: 2, Issue:25 Topics: Adult; Aged; Alcohol Drinking; Aspirin; Australia; Divorce; Duodenal Ulcer; Educational Status; Fami	1968
Aspirin and uncomplicated peptic ulcer. Gut, 1969, Volume: 10, Issue:6 Topics: Adolescent; Adult; Age Factors; Aged; Aspirin; Australia; Child; Duodenal Ulcer; Female; Humans; Mal	1969
Gastric and duodenal ulcer. The association between aspirin ingestion, smoking and family history of ulcer. The Medical journal of Australia, 1969, Aug-09, Volume: 2, Issue:6 Topics: Adolescent; Adult; Age Factors; Aged; Aspirin; Australia; Duodenal Ulcer; Female; Humans; Male; Midd	1969
The relationship between perforated peptic ulcer and aspirin ingestion. The Medical journal of Australia, 1965, Oct-16, Volume: 2, Issue:16 Topics: Aged; Aspirin; Duodenal Ulcer; Dyspepsia; Female; Humans; Male; Middle Aged; Peptic Ulcer Perforatio	1965
The pattern of duodenal ulceration in Nairobi. East African medical journal, 1965, Volume: 42, Issue:11 Topics: Adolescent; Adult; Aged; Aspirin; Black or African American; Black People; Blood Group Antigens; Chi	1965
Multiple peptic ulcers after salicylate ingestion. Northwest medicine, 1966, Volume: 65, Issue:6 Topics: Aged; Aspirin; Duodenal Ulcer; Female; Humans; Stomach Ulcer	1966

aspirin and Curling Ulcer