aspirin has been researched along with Coma in 28 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study suggests that impaired response to both intravenous and oral aspirin is frequent in comatose patients resuscitated from OHCA." | 9.22 | Impaired biological response to aspirin in therapeutic hypothermia comatose patients resuscitated from out-of-hospital cardiac arrest. ( Bal Dit Sollier, C; Deye, N; Dillinger, JG; Drouet, L; Henry, P; Llitjos, JF; Megarbane, B; Sideris, G; Voicu, S, 2016) |
| "Comatose survivors of out of hospital cardiac arrest were included and divided into two groups, depending on whether dual platelet inhibition with peroral ticagrelor and aspirin was given or not." | 7.80 | Platelet aggregation and clot formation in comatose survivors of cardiac arrest treated with induced hypothermia and dual platelet inhibition with aspirin and ticagrelor; a prospective observational study. ( Dankiewicz, J; Friberg, H; Kander, T; Schött, U, 2014) |
| "This study suggests that impaired response to both intravenous and oral aspirin is frequent in comatose patients resuscitated from OHCA." | 5.22 | Impaired biological response to aspirin in therapeutic hypothermia comatose patients resuscitated from out-of-hospital cardiac arrest. ( Bal Dit Sollier, C; Deye, N; Dillinger, JG; Drouet, L; Henry, P; Llitjos, JF; Megarbane, B; Sideris, G; Voicu, S, 2016) |
| "Comatose survivors of out of hospital cardiac arrest were included and divided into two groups, depending on whether dual platelet inhibition with peroral ticagrelor and aspirin was given or not." | 3.80 | Platelet aggregation and clot formation in comatose survivors of cardiac arrest treated with induced hypothermia and dual platelet inhibition with aspirin and ticagrelor; a prospective observational study. ( Dankiewicz, J; Friberg, H; Kander, T; Schött, U, 2014) |
| "Seven children with juvenile rheumatoid arthritis had a syndrome characterized by hemorrhage and neurologic, hepatic, hematologic, and metabolic manifestations." | 1.27 | Acute hemorrhagic, hepatic, and neurologic manifestations in juvenile rheumatoid arthritis: possible relationship to drugs or infection. ( Griscelli, C; Hadchouel, M; Prieur, AM, 1985) |
| "The vomiting of Reye's syndrome is usually persistent, lasting for 24 to 96 hours before the onset of serious brain signs." | 1.27 | Management of Reye's syndrome: need for early diagnosis and intravenous treatment of stage I non-comatose cases. ( Partin, JC, 1985) |
| "We conclude that prolonged coma without evidence of major central nervous system structural lesions in TTP should be treated vigorously and continuously with plasma exchange." | 1.26 | Thrombotic thrombocytopenic purpura: prolonged coma with recovery of neurologic function with intensive plasma exchange. ( Frankel, AE; Rubenstein, MD; Wall, RT, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (60.71) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 6 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Li, J | 1 |
| Chen, M | 1 |
| Yang, T | 1 |
| Ruan, Z | 1 |
| Su, J | 1 |
| Xing, Y | 1 |
| Selves, A | 1 |
| Ruiz, S | 1 |
| Crognier, L | 1 |
| Conil, JM | 1 |
| Bonneville, F | 1 |
| Georges, B | 1 |
| Dupuy, M | 1 |
| Fourcade, O | 1 |
| Geeraerts, T | 1 |
| Kander, T | 1 |
| Dankiewicz, J | 1 |
| Friberg, H | 1 |
| Schött, U | 1 |
| Gouffran, G | 1 |
| Rosencher, J | 1 |
| Bougouin, W | 1 |
| Jakamy, R | 1 |
| Joffre, J | 1 |
| Lamhaut, L | 1 |
| Dumas, F | 1 |
| Cariou, A | 1 |
| Varenne, O | 1 |
| Llitjos, JF | 1 |
| Sideris, G | 1 |
| Voicu, S | 1 |
| Bal Dit Sollier, C | 1 |
| Deye, N | 1 |
| Megarbane, B | 1 |
| Drouet, L | 1 |
| Henry, P | 1 |
| Dillinger, JG | 1 |
| Catez, E | 1 |
| Ngoc, ET | 1 |
| Decoodt, P | 1 |
| Schmidt, T | 1 |
| Tsakiris, DA | 1 |
| Grapow, M | 1 |
| Siegemund, M | 1 |
| MITSUSE, J | 1 |
| MORIYAMA, K | 1 |
| MUIR, GG | 1 |
| BENSON, S | 1 |
| BEVERIDGE, GW | 1 |
| FORSHALL, W | 1 |
| MUNRO, JF | 1 |
| OWEN, JA | 1 |
| WESTON, IA | 1 |
| PICKERING, D | 1 |
| GILES, HM | 1 |
| Xia, JX | 1 |
| Wang, YX | 1 |
| Dove, DJ | 1 |
| Jones, T | 1 |
| Frankel, AE | 1 |
| Rubenstein, MD | 1 |
| Wall, RT | 1 |
| Watson, JE | 1 |
| Tagupa, ET | 1 |
| Herren, T | 1 |
| Como, F | 1 |
| Krähenbühl, S | 1 |
| Wyss, PA | 1 |
| Yoshida, I | 1 |
| Yoshino, M | 1 |
| Watanabe, J | 1 |
| Yamashita, F | 1 |
| Ninane, J | 1 |
| Mahieu, P | 1 |
| Hassoun, A | 1 |
| Goenen, M | 1 |
| Good, AE | 1 |
| Welch, MH | 1 |
| Bogusz, M | 1 |
| Gogoll, L | 1 |
| Bentsen, P | 1 |
| Hochrein, H | 1 |
| Hadchouel, M | 1 |
| Prieur, AM | 1 |
| Griscelli, C | 1 |
| Partin, JC | 1 |
| Done, AK | 1 |
| Temple, AR | 1 |
| Coldwell, BB | 1 |
| Boyd, EM | 1 |
| Strauss, RG | 1 |
| McAdams, AJ | 1 |
| Gietko, M | 1 |
| Ilowiecka, K | 1 |
| Worowska, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Platelet Inhibition With Cangrelor in Comatose Survivors of Out-of-hospital Cardiac Arrest Undergoing Primary Percutaneous Coronary Intervention[NCT04005729] | Phase 4 | 30 participants (Actual) | Interventional | 2019-07-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for aspirin and Coma
| Article | Year |
|---|---|
A Meta-Analysis of Randomized and Observational Studies: Aspirin Protects from Cardiac Surgery-Associated Acute Kidney Injury.
Topics: Acute Kidney Injury; Aspirin; Cause of Death; Coma; Coronary Artery Bypass; Heart Arrest; Heart Bloc | 2019 |
[Therapy of acute salicylate poisoning].
Topics: Aspirin; Charcoal; Coma; Fatal Outcome; Female; Fever; Gastric Lavage; Glycine; Hemoperfusion; Human | 1993 |
Treatment of salicylate poisoning.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Acute Kidney Injury; Alkalosis, Respiratory; Aspirin | 1971 |
1 trial available for aspirin and Coma
| Article | Year |
|---|---|
Impaired biological response to aspirin in therapeutic hypothermia comatose patients resuscitated from out-of-hospital cardiac arrest.
Topics: Acute Coronary Syndrome; Administration, Intravenous; Administration, Oral; Adult; Aged; Aspirin; Ca | 2016 |
24 other studies available for aspirin and Coma
| Article | Year |
|---|---|
[Aspirin and its danger: Reye syndrome in young adult].
Topics: Acyclovir; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Aspirin; Brain Edema; Coma; De | 2013 |
Platelet aggregation and clot formation in comatose survivors of cardiac arrest treated with induced hypothermia and dual platelet inhibition with aspirin and ticagrelor; a prospective observational study.
Topics: Adenosine; Adult; Aged; Aspirin; Blood Platelets; Coma; Combined Modality Therapy; Drug Therapy, Com | 2014 |
Stent thrombosis after primary percutaneous coronary intervention in comatose survivors of out-of-hospital cardiac arrest: Are the new P2Y12 inhibitors really more effective than clopidogrel?
Topics: Adenosine; Aspirin; Clopidogrel; Coma; Coronary Angiography; Coronary Thrombosis; Drug Therapy, Comb | 2016 |
Fulminant hepatic necrosis resulting from heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Cardiomyopathy, Dilated; Coma; Diagnosis, Differe | 2009 |
[Thrombotic microangiopathy after extracorporeal circulation: important differential diagnosis].
Topics: ADAM Proteins; ADAMTS13 Protein; Aged, 80 and over; Aortic Diseases; Aspirin; Coma; Critical Care; D | 2011 |
[PULMONARY ENCEPHALOPATHY].
Topics: Acidosis; Aspirin; Bicarbonates; Brain Diseases; Carbon Dioxide; Coma; Electroencephalography; Human | 1964 |
SCREENING TEST FOR HIGH SERUM SALICYLATE LEVELS.
Topics: Aspirin; Blood Chemical Analysis; Body Fluids; Coma; Indicators and Reagents; Salicylates; Toxicolog | 1964 |
ACUTE SALICYLATE POISONING IN ADULTS.
Topics: Acute Kidney Injury; Aspirin; Blood Chemical Analysis; Bronchopneumonia; Coma; Diagnosis, Differenti | 1964 |
SALICYLATE POISONING: THE DIAGNOSIS WHEN ITS POSSIBILITY IS DENIED BY THE PARENTS.
Topics: Aspirin; Child; Coma; Diabetic Coma; Diagnosis; Diagnosis, Differential; Humans; Hyperglycemia; Infa | 1964 |
ENCEPHALOPATHY AND FATTY DEGENERATION OF THE VISCERA.
Topics: Aspirin; Brain Diseases; Carbohydrate Metabolism; Coma; Fatty Liver; Heart Diseases; Humans; Kidney | 1965 |
[Oral aspirin caused Reye's syndrome in a child].
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Edema; Child; Coma; Fe | 2004 |
Delayed coma associated with salicylate intoxication.
Topics: Aspirin; Brain Edema; Child, Preschool; Coma; Female; Humans; Infant; Mannitol; Salicylates; Time Fa | 1982 |
Thrombotic thrombocytopenic purpura: prolonged coma with recovery of neurologic function with intensive plasma exchange.
Topics: Aspirin; Coma; Dipyridamole; Female; Humans; Middle Aged; Plasma Exchange; Platelet Count; Prednisol | 1981 |
Suicide attempt by means of aspirin enema.
Topics: Administration, Rectal; Adult; Aspirin; Coma; Enema; Female; Humans; Intestinal Absorption; Rectum; | 1994 |
Sudden onset of ornithine carbamoyltransferase deficiency after aspirin ingestion.
Topics: Adult; Aspirin; Coma; Humans; Male; Ornithine Carbamoyltransferase Deficiency Disease; Reye Syndrome | 1993 |
[Unusual side effects following administration of dipyrone and acetylsalicylic acid].
Topics: Aminopyrine; Aspirin; Child; Coma; Dipyrone; Female; Humans | 1978 |
Hospital-acquired salicylate intoxication. report of a case with psychosis, acidosis, and coma.
Topics: Acidosis; Arthritis, Rheumatoid; Aspirin; Coma; Hospitalization; Humans; Iatrogenic Disease; Male; M | 1975 |
The usefulness of the enzymatic tests in acute poisonings.
Topics: Adolescent; Adult; Aged; Alcohol Oxidoreductases; Alcoholic Intoxication; Alkaline Phosphatase; Aspi | 1975 |
[Cerebral complications in chronic acetylsalicylic acid poisoning].
Topics: Aspirin; Chronic Disease; Cognition Disorders; Coma; Combined Modality Therapy; Consciousness Disord | 1989 |
Acute hemorrhagic, hepatic, and neurologic manifestations in juvenile rheumatoid arthritis: possible relationship to drugs or infection.
Topics: Acute Disease; Arthritis, Juvenile; Aspirin; Bacterial Infections; Child; Child, Preschool; Coma; Di | 1985 |
Management of Reye's syndrome: need for early diagnosis and intravenous treatment of stage I non-comatose cases.
Topics: Aspirin; Chickenpox; Coma; Glucose; Humans; Influenza, Human; Infusions, Parenteral; Reye Syndrome | 1985 |
The acute rectal toxicity of acetylsalicylic acid.
Topics: Adrenal Glands; Animals; Aspirin; Ataxia; Body Weight; Brain; Coma; Diarrhea; Diuresis; Dyspnea; Fee | 1966 |
Arthritis, aspirin, and coma.
Topics: Arthritis, Juvenile; Aspirin; Brain Edema; Chemical and Drug Induced Liver Injury; Child, Preschool; | 1970 |
[Severe hypoglycemic coma in a 4-month-old infant during treatment with aspirin].
Topics: Acidosis; Acute Disease; Age Factors; Aspirin; Carbohydrate Metabolism; Coma; Humans; Hypoglycemia; | 1970 |