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aspirin and Cocarcinogenesis

aspirin has been researched along with Cocarcinogenesis in 5 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Cocarcinogenesis: The combination of two or more different factors in the production of cancer.

Research Excerpts

ExcerptRelevanceReference
" These occurred only in the groups given MNNG in combination with stress, aspirin, or sodium taurocholate, and did not occur in experimental groups given either MNNG, stress, aspirin, or sodium taurocholate alone, and did not occur in the control group."5.27Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate. ( Cohen, A; Geller, SA; Horowitz, I; Toth, LS; Werther, JL, 1984)
" These occurred only in the groups given MNNG in combination with stress, aspirin, or sodium taurocholate, and did not occur in experimental groups given either MNNG, stress, aspirin, or sodium taurocholate alone, and did not occur in the control group."1.27Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate. ( Cohen, A; Geller, SA; Horowitz, I; Toth, LS; Werther, JL, 1984)
"Aspirin is an inhibitor of prostaglandin H synthase and has been shown to inhibit FANFT-induced bladder carcinogenesis when coadministered in the diet."1.27Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide initiation and sodium saccharin promotion of urinary bladder carcinogenesis in male F344 rats. ( Cohen, SM; Hasegawa, R; Johansson, SL; Sakata, T; Zenser, TV, 1986)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19903 (60.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pandeya, N1
Webb, PM1
Sadeghi, S1
Green, AC1
Whiteman, DC1
Chang, TH1
Lee, YC1
Lee, KY1
Sun, CH1
Chang, YP1
Cohen, A1
Geller, SA1
Horowitz, I1
Toth, LS1
Werther, JL1
Ma, J1
Stampfer, MJ1
Giovannucci, E1
Artigas, C1
Hunter, DJ1
Fuchs, C1
Willett, WC1
Selhub, J1
Hennekens, CH1
Rozen, R1
Sakata, T1
Hasegawa, R1
Johansson, SL1
Zenser, TV1
Cohen, SM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Impact of Folates in the Care of the Male Infertility[NCT01407432]Phase 3162 participants (Actual)Interventional2011-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for aspirin and Cocarcinogenesis

ArticleYear
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.
    Cancer research, 1997, Mar-15, Volume: 57, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Aspirin; beta Carotene; Case-Control Studies; Coca

1997

Other Studies

4 other studies available for aspirin and Cocarcinogenesis

ArticleYear
Gastro-oesophageal reflux symptoms and the risks of oesophageal cancer: are the effects modified by smoking, NSAIDs or acid suppressants?
    Gut, 2010, Volume: 59, Issue:1

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Aspirin;

2010
Cocarcinogenic action of aspirin on gastric tumors induced by N-nitroso-N-methylnitroguanidine in rats.
    Journal of the National Cancer Institute, 1983, Volume: 70, Issue:6

    Topics: Adenocarcinoma; Animals; Aspirin; Carcinoma, Squamous Cell; Cocarcinogenesis; Female; Humans; Male;

1983
Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate.
    Cancer, 1984, Mar-01, Volume: 53, Issue:5

    Topics: Adenocarcinoma; Animals; Aspirin; Cocarcinogenesis; Diet; Disease Models, Animal; Leiomyosarcoma; Ma

1984
Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide initiation and sodium saccharin promotion of urinary bladder carcinogenesis in male F344 rats.
    Cancer research, 1986, Volume: 46, Issue:8

    Topics: Animals; Aspirin; Body Weight; Cocarcinogenesis; FANFT; Hydrogen-Ion Concentration; Male; Rats; Rats

1986