Page last updated: 2024-10-23

aspirin and Cirrhosis

aspirin has been researched along with Cirrhosis in 28 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to compare the effect of Neoral cyclosporin- and tacrolimus-based therapy on the development of renal allograft fibrosis (chronic allograft nephropathy; CAN) in a prospective randomized trial."9.10Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis. ( Furness, PN; Murphy, GJ; Nicholson, ML; Sandford, RS; Waller, JR, 2003)
"We assessed the effects of ticagrelor, aspirin and prasugrel, started 7days after myocardial ischemia-reperfusion injury on remodeling, inflammation and fibrosis in the rat."7.91Ticagrelor Improves Remodeling, Reduces Apoptosis, Inflammation and Fibrosis and Increases the Number of Progenitor Stem Cells After Myocardial Infarction in a Rat Model of Ischemia Reperfusion. ( Birnbaum, Y; Chen, H; Nylander, S; Sampaio, LC; Tran, D; Ye, Y, 2019)
"Our study reveals a novel mechanism by which aspirin alleviates pressure overload-induced cardiac interstitial fibrosis in TAC mice by suppressing the p-Erk1/2 and p-Akt/β-catenin signalling pathways."7.88Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways. ( E, X; Feng, Y; Gitau, SC; Li, T; Li, X; Liang, H; Liu, X; Qian, M; QiLi, M; Shan, H; Shen, Z; Wang, G; Xu, B; Zhang, Y; Zhao, D, 2018)
"The aim of this study was to examine the effect of the antithrombotic drugs aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of liver cirrhosis and to determine if these two drugs are beneficial in animals with advanced fibrosis or with established cirrhosis undergoing partial hepatectomy."7.74The beneficial effect of aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of cirrhosis. ( Assy, N; Hussein, O; Khalil, A; Luder, A; Paizi, M; Spira, G; Szvalb, S, 2007)
" The dosage of aspirin was 30 mg/kg orally during the acute febrile stage and 5-10 mg/kg orally after lysis of fever."6.67Histopathologic and coronary angiographic assessment of effectiveness of aspirin or aspirin-and-gammaglobulin in Kawasaki disease. ( Haneda, N; Mori, C, 1993)
"For aspirin, the RR was 1."5.91Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials. ( Christensen, DH; Eiset, AH; Jepsen, P; Kraglund, F; Villadsen, GE; West, J, 2023)
"Inflammation-driven scarring is a major contributor to surgical failure after subconjunctival bleb forming glaucoma surgery."5.72Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery. ( Armstrong, JJ; Hutnik, CML; Liu, H; Vinokurtseva, A, 2022)
"Warfarin treatment within 12 months achieved significantly higher rates of complete recanalization than aspirin or clopidogrel in patients with PVT (54."5.48Portal Vein Thrombosis in Patients With Cirrhosis Undergoing Elective Transjugular Intrahepatic Portosystemic Shunt: Risk Factors, Warfarin Efficacy, and Clinical Outcomes. ( Li, YH; Wu, HM; Xu, Y; Yang, J; Yang, LH; Yue-Meng, W, 2018)
"The aim of this study was to compare the effect of Neoral cyclosporin- and tacrolimus-based therapy on the development of renal allograft fibrosis (chronic allograft nephropathy; CAN) in a prospective randomized trial."5.10Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis. ( Furness, PN; Murphy, GJ; Nicholson, ML; Sandford, RS; Waller, JR, 2003)
"A total of 109 eyes (in 96 persons) with SRF, defined as a mound or sheet of gray to white tissue beneath the retina at or near the center of the macula, were identified during the Early Treatment Diabetic Retinopathy Study, which is a randomized clinical trial of photocoagulation and aspirin treatment in patients with mild to severe nonproliferative or early proliferative diabetic retinopathy."5.08Subretinal fibrosis in diabetic macular edema. ETDRS report 23. Early Treatment Diabetic Retinopathy Study Research Group. ( Davis, MD; Ferris, FL; Fong, DS; Hubbard, LD; Myers, F; Segal, PP, 1997)
"We assessed the effects of ticagrelor, aspirin and prasugrel, started 7days after myocardial ischemia-reperfusion injury on remodeling, inflammation and fibrosis in the rat."3.91Ticagrelor Improves Remodeling, Reduces Apoptosis, Inflammation and Fibrosis and Increases the Number of Progenitor Stem Cells After Myocardial Infarction in a Rat Model of Ischemia Reperfusion. ( Birnbaum, Y; Chen, H; Nylander, S; Sampaio, LC; Tran, D; Ye, Y, 2019)
"Our study reveals a novel mechanism by which aspirin alleviates pressure overload-induced cardiac interstitial fibrosis in TAC mice by suppressing the p-Erk1/2 and p-Akt/β-catenin signalling pathways."3.88Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways. ( E, X; Feng, Y; Gitau, SC; Li, T; Li, X; Liang, H; Liu, X; Qian, M; QiLi, M; Shan, H; Shen, Z; Wang, G; Xu, B; Zhang, Y; Zhao, D, 2018)
"Aspirin administration, reduced the protein expression of Mysm1, increased the protein expression of H2AK119-Ub and thereby reduced the Set7 protein expression in glomeruli isolated from diabetic animals and prevented renal fibrosis."3.88Novel reno-protective mechanism of Aspirin involves H2AK119 monoubiquitination and Set7 in preventing type 1 diabetic nephropathy. ( Gaikwad, AB; Goru, SK, 2018)
"The risk of hemorrhagic complications after extracorporeal shock-wave lithotripsy (ESWL) increases in patients with aspirin intake, but the hematoma-inducing mechanism has not been understood completely at the ultrastructural level."3.74[Extracorporeal shock-wave lithotripsy induced ultrastructural changes to the renal parenchyma under aspirin use. Electron microscopic findings in the rat kidney]. ( Fischer, C; Morgenroth, K; Pastor, J; Senge, T; Wöhrle, J, 2007)
"The aim of this study was to examine the effect of the antithrombotic drugs aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of liver cirrhosis and to determine if these two drugs are beneficial in animals with advanced fibrosis or with established cirrhosis undergoing partial hepatectomy."3.74The beneficial effect of aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of cirrhosis. ( Assy, N; Hussein, O; Khalil, A; Luder, A; Paizi, M; Spira, G; Szvalb, S, 2007)
"Low-dose aspirin (acetylsalicylic acid; ASA), inhibiting platelet thromboxane production in favor of endothelium formation of prostaglandins, is successfully used as primary or secondary prophylaxis against myocardial infarction."3.69Chronic aspirin treatment affects collagen deposition in non-infarcted myocardium during remodeling after coronary artery ligation in the rat. ( Kalkman, EA; Saxena, PR; Schoemaker, RG; van Dijk, JP; van Suylen, RJ, 1995)
" The dosage of aspirin was 30 mg/kg orally during the acute febrile stage and 5-10 mg/kg orally after lysis of fever."2.67Histopathologic and coronary angiographic assessment of effectiveness of aspirin or aspirin-and-gammaglobulin in Kawasaki disease. ( Haneda, N; Mori, C, 1993)
"For aspirin, the RR was 1."1.91Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials. ( Christensen, DH; Eiset, AH; Jepsen, P; Kraglund, F; Villadsen, GE; West, J, 2023)
"Inflammation-driven scarring is a major contributor to surgical failure after subconjunctival bleb forming glaucoma surgery."1.72Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery. ( Armstrong, JJ; Hutnik, CML; Liu, H; Vinokurtseva, A, 2022)
"Fibrosis was significantly less in treated mice atria."1.62Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation. ( Dixit, G; Li, Z; Ozcan, C, 2021)
"Warfarin treatment within 12 months achieved significantly higher rates of complete recanalization than aspirin or clopidogrel in patients with PVT (54."1.48Portal Vein Thrombosis in Patients With Cirrhosis Undergoing Elective Transjugular Intrahepatic Portosystemic Shunt: Risk Factors, Warfarin Efficacy, and Clinical Outcomes. ( Li, YH; Wu, HM; Xu, Y; Yang, J; Yang, LH; Yue-Meng, W, 2018)
"Endoscopic features of eosinophilic esophagitis (EoE) are variable with at least 2 phenotypes."1.43Impact of Diagnostic Delay and Other Risk Factors on Eosinophilic Esophagitis Phenotype and Esophageal Diameter. ( Kumar, A; Lipka, S; Richter, JE, 2016)
"Chronic myocardial ischemia was induced using a minimally invasive model in 16 landrace pigs."1.37Gene therapy with iNOS enhances regional contractility and reduces delayed contrast enhancement in a model of postischemic congestive heart failure. ( Abegunewardene, N; Gori, T; Horstick, G; Kreitner, KF; Lehr, HA; Münzel, T; Schmidt, KH; Schreiber, LM; Vosseler, M, 2011)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (17.86)18.2507
2000's4 (14.29)29.6817
2010's11 (39.29)24.3611
2020's8 (28.57)2.80

Authors

AuthorsStudies
Berg, J1
Jablonowski, R1
Mohammad, M1
Solem, K1
Borgquist, R1
Ostenfeld, E1
Arheden, H1
Carlsson, M1
Vinokurtseva, A1
Armstrong, JJ1
Liu, H1
Hutnik, CML1
Kraglund, F1
Christensen, DH1
Eiset, AH1
Villadsen, GE1
West, J1
Jepsen, P1
Birnbaum, Y1
Tran, D1
Chen, H1
Nylander, S1
Sampaio, LC1
Ye, Y1
Severo, MD1
Zhang, Z1
Li, S1
Deng, J1
Yang, S1
Xiang, Z1
Guo, H1
Xi, H1
Sang, M1
Zhang, W1
Ozcan, C1
Dixit, G1
Li, Z1
D'Agostino, I1
Tacconelli, S1
Bruno, A1
Contursi, A1
Mucci, L1
Hu, X1
Xie, Y1
Chakraborty, R1
Jain, K1
Sacco, A1
Zucchelli, M1
Landolfi, R1
Dovizio, M1
Falcone, L1
Ballerini, P1
Hwa, J1
Patrignani, P1
Li, X1
Wang, G1
QiLi, M1
Liang, H1
Li, T1
E, X1
Feng, Y1
Zhang, Y1
Liu, X1
Qian, M1
Xu, B1
Shen, Z1
Gitau, SC1
Zhao, D1
Shan, H1
Goru, SK1
Gaikwad, AB1
Simon, TG1
Corey, KE1
Pecci, A1
Croci, G1
Balduini, CL1
Boveri, E1
Siddesha, JM1
Valente, AJ1
Sakamuri, SS1
Gardner, JD1
Delafontaine, P1
Noda, M1
Chandrasekar, B1
Lipka, S1
Kumar, A1
Richter, JE1
Lu, Y1
Yue-Meng, W1
Li, YH1
Wu, HM1
Yang, J1
Yang, LH1
Xu, Y1
Liu, PP1
Liu, HH1
Sun, SH1
Shi, XX1
Yang, WC1
Su, GH1
Zhao, J1
Abegunewardene, N1
Schmidt, KH1
Vosseler, M1
Kreitner, KF1
Schreiber, LM1
Lehr, HA1
Gori, T1
Münzel, T1
Horstick, G1
Wu, R1
Yin, D1
Sadekova, N1
Deschepper, CF1
de Champlain, J1
Girouard, H1
Murphy, GJ1
Waller, JR1
Sandford, RS1
Furness, PN1
Nicholson, ML1
Breyer, MD1
Fischer, C1
Wöhrle, J1
Pastor, J1
Morgenroth, K1
Senge, T1
Assy, N1
Hussein, O1
Khalil, A1
Luder, A1
Szvalb, S1
Paizi, M1
Spira, G1
Haneda, N1
Mori, C1
Pearl, JM1
Laks, H1
Barthell, S1
Drinkwater, DC1
Capouya, ER1
Chang, PA1
Kalkman, EA1
van Suylen, RJ1
van Dijk, JP1
Saxena, PR1
Schoemaker, RG1
Fong, DS1
Segal, PP1
Myers, F1
Ferris, FL1
Hubbard, LD1
Davis, MD1
Boerboom, LE1
Olinger, GN1
Liu, TZ1
Rodriguez, ER1
Ferrans, VJ1
Kissebah, AH1

Trials

3 trials available for aspirin and Cirrhosis

ArticleYear
Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis.
    The British journal of surgery, 2003, Volume: 90, Issue:6

    Topics: Adult; Analysis of Variance; Aspirin; Cyclosporine; Extracellular Matrix; Female; Fibrosis; Graft Re

2003
Histopathologic and coronary angiographic assessment of effectiveness of aspirin or aspirin-and-gammaglobulin in Kawasaki disease.
    Acta paediatrica Japonica : Overseas edition, 1993, Volume: 35, Issue:4

    Topics: Acute Disease; Aspirin; Biopsy; Cardiomyopathies; Child; Child, Preschool; Coronary Aneurysm; Corona

1993
Subretinal fibrosis in diabetic macular edema. ETDRS report 23. Early Treatment Diabetic Retinopathy Study Research Group.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetic Retinopathy; Exudates and Transudates; Fi

1997

Other Studies

25 other studies available for aspirin and Cirrhosis

ArticleYear
Ventricular longitudinal shortening is an independent predictor of death in heart failure patients with reduced ejection fraction.
    Scientific reports, 2021, 10-13, Volume: 11, Issue:1

    Topics: Aged; Aspirin; Body Mass Index; Cicatrix; Diuretics; Female; Fibrosis; Follow-Up Studies; Heart Fail

2021
Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery.
    Experimental eye research, 2022, Volume: 225

    Topics: Aspirin; Cell Transdifferentiation; Cells, Cultured; Chromatography, Liquid; Cicatrix; Collagen; Cyt

2022
Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials.
    Hepatology communications, 2023, 01-01, Volume: 7, Issue:1

    Topics: Aspirin; Carcinoma, Hepatocellular; Fibrosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors

2023
Ticagrelor Improves Remodeling, Reduces Apoptosis, Inflammation and Fibrosis and Increases the Number of Progenitor Stem Cells After Myocardial Infarction in a Rat Model of Ischemia Reperfusion.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2019, Volume: 53, Issue:6

    Topics: Animals; Apoptosis; Aspirin; Atrial Natriuretic Factor; Disease Models, Animal; Drug Therapy, Combin

2019
Daily Aspirin Use Associated With Reduced Risk for Fibrosis Progression in Patients With Nonalcoholic Fatty Liver Disease.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2020, Volume: 18, Issue:2

    Topics: Aspirin; Disease Progression; Fibrosis; Humans; Liver Cirrhosis; Non-alcoholic Fatty Liver Disease

2020
Aspirin inhibits endometrial fibrosis by suppressing the TGF‑β1‑Smad2/Smad3 pathway in intrauterine adhesions.
    International journal of molecular medicine, 2020, Volume: 45, Issue:5

    Topics: Adult; Aspirin; Endometrium; Estrogens; Female; Fibrosis; Humans; Neovascularization, Pathologic; Re

2020
Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation.
    Journal of cardiovascular translational research, 2021, Volume: 14, Issue:3

    Topics: AMP-Activated Protein Kinases; Animals; Anti-Arrhythmia Agents; Aspirin; Atrial Fibrillation; Atrial

2021
Low-dose Aspirin prevents hypertension and cardiac fibrosis when thromboxane A
    Pharmacological research, 2021, Volume: 170

    Topics: Adult; Animals; Antifibrotic Agents; Antihypertensive Agents; Aspirin; Biomarkers; Blood Platelets;

2021
Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 45, Issue:5

    Topics: Actins; Angiotensin II; Animals; Aspirin; beta Catenin; Cell Line; Collagen Type I; Disease Models,

2018
Novel reno-protective mechanism of Aspirin involves H2AK119 monoubiquitination and Set7 in preventing type 1 diabetic nephropathy.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:3

    Topics: Animals; Aspirin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies

2018
Reply.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2020, Volume: 18, Issue:2

    Topics: Aspirin; Disease Progression; Fibrosis; Humans; Non-alcoholic Fatty Liver Disease

2020
Cutaneous involvement by post-polycythemia vera myelofibrosis.
    American journal of hematology, 2014, Volume: 89, Issue:4

    Topics: Aged; Aspirin; Biopsy; Cell Lineage; Disease Progression; Drug Therapy, Combination; Fibrosis; Hemat

2014
Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK.
    Journal of cellular physiology, 2014, Volume: 229, Issue:7

    Topics: Animals; Aspirin; Biomarkers, Tumor; Cell Line; Cell Movement; Collagen; Drug Combinations; Fibrobla

2014
Impact of Diagnostic Delay and Other Risk Factors on Eosinophilic Esophagitis Phenotype and Esophageal Diameter.
    Journal of clinical gastroenterology, 2016, Volume: 50, Issue:2

    Topics: Adult; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chi-Square Distribution;

2016
Letter: would aspirin alleviate fibrosis in alcoholic liver disease?
    Alimentary pharmacology & therapeutics, 2016, Volume: 44, Issue:2

    Topics: Aspirin; Fibrosis; Humans; Liver; Liver Cirrhosis, Alcoholic; Liver Diseases, Alcoholic

2016
Portal Vein Thrombosis in Patients With Cirrhosis Undergoing Elective Transjugular Intrahepatic Portosystemic Shunt: Risk Factors, Warfarin Efficacy, and Clinical Outcomes.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2018, Volume: 24, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Elective Surgical Procedures; Female; Fibrosis

2018
Aspirin alleviates cardiac fibrosis in mice by inhibiting autophagy.
    Acta pharmacologica Sinica, 2017, Volume: 38, Issue:4

    Topics: Animals; Apoptosis; Aspirin; Autophagy; Cardiomyopathies; Cardiotonic Agents; Cell Hypoxia; Fibrobla

2017
Gene therapy with iNOS enhances regional contractility and reduces delayed contrast enhancement in a model of postischemic congestive heart failure.
    Clinical hemorheology and microcirculation, 2011, Volume: 49, Issue:1-4

    Topics: Animals; Anticoagulants; Aspirin; Clopidogrel; Contrast Media; Coronary Angiography; Coronary Stenos

2011
Protective effects of aspirin from cardiac hypertrophy and oxidative stress in cardiomyopathic hamsters.
    Oxidative medicine and cellular longevity, 2012, Volume: 2012

    Topics: Animals; Aorta; Aspirin; Blood Pressure; Body Weight; Cardiomegaly; Cardiomyopathies; Cardiotonic Ag

2012
Getting to the heart of COX-2 inhibition.
    Cell metabolism, 2005, Volume: 2, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Blood Pressure;

2005
[Extracorporeal shock-wave lithotripsy induced ultrastructural changes to the renal parenchyma under aspirin use. Electron microscopic findings in the rat kidney].
    Der Urologe. Ausg. A, 2007, Volume: 46, Issue:2

    Topics: Animals; Apoptosis; Aspirin; Capillary Fragility; Fibrinolytic Agents; Fibrosis; Hematoma; Kidney; K

2007
The beneficial effect of aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of cirrhosis.
    Digestive diseases and sciences, 2007, Volume: 52, Issue:5

    Topics: Animals; Aspartate Aminotransferases; Aspirin; Bilirubin; Disease Progression; Enoxaparin; Fibrinoly

2007
Spontaneous closure of fenestrations in an interatrial Gore-Tex patch: application to the Fontan procedure.
    The Annals of thoracic surgery, 1994, Volume: 57, Issue:3

    Topics: Animals; Aspirin; Blood Platelets; Blood Vessel Prosthesis; Cardiac Surgical Procedures; Dogs; Fibro

1994
Chronic aspirin treatment affects collagen deposition in non-infarcted myocardium during remodeling after coronary artery ligation in the rat.
    Journal of molecular and cellular cardiology, 1995, Volume: 27, Issue:11

    Topics: Animals; Aspirin; Collagen; Coronary Vessels; Dose-Response Relationship, Drug; Eicosanoids; Endothe

1995
Histologic, morphometric, and biochemical evolution of vein bypass grafts in a nonhuman primate model. III. Long-term changes and their modification by platelet inhibition with aspirin and dipyridamole.
    The Journal of thoracic and cardiovascular surgery, 1990, Volume: 99, Issue:3

    Topics: Animals; Aspirin; Cholesterol; Dipyridamole; Drug Administration Schedule; Endothelium, Vascular; Fe

1990