aspirin has been researched along with Cirrhosis in 28 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to compare the effect of Neoral cyclosporin- and tacrolimus-based therapy on the development of renal allograft fibrosis (chronic allograft nephropathy; CAN) in a prospective randomized trial." | 9.10 | Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis. ( Furness, PN; Murphy, GJ; Nicholson, ML; Sandford, RS; Waller, JR, 2003) |
| "We assessed the effects of ticagrelor, aspirin and prasugrel, started 7days after myocardial ischemia-reperfusion injury on remodeling, inflammation and fibrosis in the rat." | 7.91 | Ticagrelor Improves Remodeling, Reduces Apoptosis, Inflammation and Fibrosis and Increases the Number of Progenitor Stem Cells After Myocardial Infarction in a Rat Model of Ischemia Reperfusion. ( Birnbaum, Y; Chen, H; Nylander, S; Sampaio, LC; Tran, D; Ye, Y, 2019) |
| "Our study reveals a novel mechanism by which aspirin alleviates pressure overload-induced cardiac interstitial fibrosis in TAC mice by suppressing the p-Erk1/2 and p-Akt/β-catenin signalling pathways." | 7.88 | Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways. ( E, X; Feng, Y; Gitau, SC; Li, T; Li, X; Liang, H; Liu, X; Qian, M; QiLi, M; Shan, H; Shen, Z; Wang, G; Xu, B; Zhang, Y; Zhao, D, 2018) |
| "The aim of this study was to examine the effect of the antithrombotic drugs aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of liver cirrhosis and to determine if these two drugs are beneficial in animals with advanced fibrosis or with established cirrhosis undergoing partial hepatectomy." | 7.74 | The beneficial effect of aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of cirrhosis. ( Assy, N; Hussein, O; Khalil, A; Luder, A; Paizi, M; Spira, G; Szvalb, S, 2007) |
| " The dosage of aspirin was 30 mg/kg orally during the acute febrile stage and 5-10 mg/kg orally after lysis of fever." | 6.67 | Histopathologic and coronary angiographic assessment of effectiveness of aspirin or aspirin-and-gammaglobulin in Kawasaki disease. ( Haneda, N; Mori, C, 1993) |
| "For aspirin, the RR was 1." | 5.91 | Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials. ( Christensen, DH; Eiset, AH; Jepsen, P; Kraglund, F; Villadsen, GE; West, J, 2023) |
| "Inflammation-driven scarring is a major contributor to surgical failure after subconjunctival bleb forming glaucoma surgery." | 5.72 | Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery. ( Armstrong, JJ; Hutnik, CML; Liu, H; Vinokurtseva, A, 2022) |
| "Warfarin treatment within 12 months achieved significantly higher rates of complete recanalization than aspirin or clopidogrel in patients with PVT (54." | 5.48 | Portal Vein Thrombosis in Patients With Cirrhosis Undergoing Elective Transjugular Intrahepatic Portosystemic Shunt: Risk Factors, Warfarin Efficacy, and Clinical Outcomes. ( Li, YH; Wu, HM; Xu, Y; Yang, J; Yang, LH; Yue-Meng, W, 2018) |
| "The aim of this study was to compare the effect of Neoral cyclosporin- and tacrolimus-based therapy on the development of renal allograft fibrosis (chronic allograft nephropathy; CAN) in a prospective randomized trial." | 5.10 | Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis. ( Furness, PN; Murphy, GJ; Nicholson, ML; Sandford, RS; Waller, JR, 2003) |
| "A total of 109 eyes (in 96 persons) with SRF, defined as a mound or sheet of gray to white tissue beneath the retina at or near the center of the macula, were identified during the Early Treatment Diabetic Retinopathy Study, which is a randomized clinical trial of photocoagulation and aspirin treatment in patients with mild to severe nonproliferative or early proliferative diabetic retinopathy." | 5.08 | Subretinal fibrosis in diabetic macular edema. ETDRS report 23. Early Treatment Diabetic Retinopathy Study Research Group. ( Davis, MD; Ferris, FL; Fong, DS; Hubbard, LD; Myers, F; Segal, PP, 1997) |
| "We assessed the effects of ticagrelor, aspirin and prasugrel, started 7days after myocardial ischemia-reperfusion injury on remodeling, inflammation and fibrosis in the rat." | 3.91 | Ticagrelor Improves Remodeling, Reduces Apoptosis, Inflammation and Fibrosis and Increases the Number of Progenitor Stem Cells After Myocardial Infarction in a Rat Model of Ischemia Reperfusion. ( Birnbaum, Y; Chen, H; Nylander, S; Sampaio, LC; Tran, D; Ye, Y, 2019) |
| "Our study reveals a novel mechanism by which aspirin alleviates pressure overload-induced cardiac interstitial fibrosis in TAC mice by suppressing the p-Erk1/2 and p-Akt/β-catenin signalling pathways." | 3.88 | Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways. ( E, X; Feng, Y; Gitau, SC; Li, T; Li, X; Liang, H; Liu, X; Qian, M; QiLi, M; Shan, H; Shen, Z; Wang, G; Xu, B; Zhang, Y; Zhao, D, 2018) |
| "Aspirin administration, reduced the protein expression of Mysm1, increased the protein expression of H2AK119-Ub and thereby reduced the Set7 protein expression in glomeruli isolated from diabetic animals and prevented renal fibrosis." | 3.88 | Novel reno-protective mechanism of Aspirin involves H2AK119 monoubiquitination and Set7 in preventing type 1 diabetic nephropathy. ( Gaikwad, AB; Goru, SK, 2018) |
| "The risk of hemorrhagic complications after extracorporeal shock-wave lithotripsy (ESWL) increases in patients with aspirin intake, but the hematoma-inducing mechanism has not been understood completely at the ultrastructural level." | 3.74 | [Extracorporeal shock-wave lithotripsy induced ultrastructural changes to the renal parenchyma under aspirin use. Electron microscopic findings in the rat kidney]. ( Fischer, C; Morgenroth, K; Pastor, J; Senge, T; Wöhrle, J, 2007) |
| "The aim of this study was to examine the effect of the antithrombotic drugs aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of liver cirrhosis and to determine if these two drugs are beneficial in animals with advanced fibrosis or with established cirrhosis undergoing partial hepatectomy." | 3.74 | The beneficial effect of aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of cirrhosis. ( Assy, N; Hussein, O; Khalil, A; Luder, A; Paizi, M; Spira, G; Szvalb, S, 2007) |
| "Low-dose aspirin (acetylsalicylic acid; ASA), inhibiting platelet thromboxane production in favor of endothelium formation of prostaglandins, is successfully used as primary or secondary prophylaxis against myocardial infarction." | 3.69 | Chronic aspirin treatment affects collagen deposition in non-infarcted myocardium during remodeling after coronary artery ligation in the rat. ( Kalkman, EA; Saxena, PR; Schoemaker, RG; van Dijk, JP; van Suylen, RJ, 1995) |
| " The dosage of aspirin was 30 mg/kg orally during the acute febrile stage and 5-10 mg/kg orally after lysis of fever." | 2.67 | Histopathologic and coronary angiographic assessment of effectiveness of aspirin or aspirin-and-gammaglobulin in Kawasaki disease. ( Haneda, N; Mori, C, 1993) |
| "For aspirin, the RR was 1." | 1.91 | Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials. ( Christensen, DH; Eiset, AH; Jepsen, P; Kraglund, F; Villadsen, GE; West, J, 2023) |
| "Inflammation-driven scarring is a major contributor to surgical failure after subconjunctival bleb forming glaucoma surgery." | 1.72 | Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery. ( Armstrong, JJ; Hutnik, CML; Liu, H; Vinokurtseva, A, 2022) |
| "Fibrosis was significantly less in treated mice atria." | 1.62 | Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation. ( Dixit, G; Li, Z; Ozcan, C, 2021) |
| "Warfarin treatment within 12 months achieved significantly higher rates of complete recanalization than aspirin or clopidogrel in patients with PVT (54." | 1.48 | Portal Vein Thrombosis in Patients With Cirrhosis Undergoing Elective Transjugular Intrahepatic Portosystemic Shunt: Risk Factors, Warfarin Efficacy, and Clinical Outcomes. ( Li, YH; Wu, HM; Xu, Y; Yang, J; Yang, LH; Yue-Meng, W, 2018) |
| "Endoscopic features of eosinophilic esophagitis (EoE) are variable with at least 2 phenotypes." | 1.43 | Impact of Diagnostic Delay and Other Risk Factors on Eosinophilic Esophagitis Phenotype and Esophageal Diameter. ( Kumar, A; Lipka, S; Richter, JE, 2016) |
| "Chronic myocardial ischemia was induced using a minimally invasive model in 16 landrace pigs." | 1.37 | Gene therapy with iNOS enhances regional contractility and reduces delayed contrast enhancement in a model of postischemic congestive heart failure. ( Abegunewardene, N; Gori, T; Horstick, G; Kreitner, KF; Lehr, HA; Münzel, T; Schmidt, KH; Schreiber, LM; Vosseler, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 4 (14.29) | 29.6817 |
| 2010's | 11 (39.29) | 24.3611 |
| 2020's | 8 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Berg, J | 1 |
| Jablonowski, R | 1 |
| Mohammad, M | 1 |
| Solem, K | 1 |
| Borgquist, R | 1 |
| Ostenfeld, E | 1 |
| Arheden, H | 1 |
| Carlsson, M | 1 |
| Vinokurtseva, A | 1 |
| Armstrong, JJ | 1 |
| Liu, H | 1 |
| Hutnik, CML | 1 |
| Kraglund, F | 1 |
| Christensen, DH | 1 |
| Eiset, AH | 1 |
| Villadsen, GE | 1 |
| West, J | 1 |
| Jepsen, P | 1 |
| Birnbaum, Y | 1 |
| Tran, D | 1 |
| Chen, H | 1 |
| Nylander, S | 1 |
| Sampaio, LC | 1 |
| Ye, Y | 1 |
| Severo, MD | 1 |
| Zhang, Z | 1 |
| Li, S | 1 |
| Deng, J | 1 |
| Yang, S | 1 |
| Xiang, Z | 1 |
| Guo, H | 1 |
| Xi, H | 1 |
| Sang, M | 1 |
| Zhang, W | 1 |
| Ozcan, C | 1 |
| Dixit, G | 1 |
| Li, Z | 1 |
| D'Agostino, I | 1 |
| Tacconelli, S | 1 |
| Bruno, A | 1 |
| Contursi, A | 1 |
| Mucci, L | 1 |
| Hu, X | 1 |
| Xie, Y | 1 |
| Chakraborty, R | 1 |
| Jain, K | 1 |
| Sacco, A | 1 |
| Zucchelli, M | 1 |
| Landolfi, R | 1 |
| Dovizio, M | 1 |
| Falcone, L | 1 |
| Ballerini, P | 1 |
| Hwa, J | 1 |
| Patrignani, P | 1 |
| Li, X | 1 |
| Wang, G | 1 |
| QiLi, M | 1 |
| Liang, H | 1 |
| Li, T | 1 |
| E, X | 1 |
| Feng, Y | 1 |
| Zhang, Y | 1 |
| Liu, X | 1 |
| Qian, M | 1 |
| Xu, B | 1 |
| Shen, Z | 1 |
| Gitau, SC | 1 |
| Zhao, D | 1 |
| Shan, H | 1 |
| Goru, SK | 1 |
| Gaikwad, AB | 1 |
| Simon, TG | 1 |
| Corey, KE | 1 |
| Pecci, A | 1 |
| Croci, G | 1 |
| Balduini, CL | 1 |
| Boveri, E | 1 |
| Siddesha, JM | 1 |
| Valente, AJ | 1 |
| Sakamuri, SS | 1 |
| Gardner, JD | 1 |
| Delafontaine, P | 1 |
| Noda, M | 1 |
| Chandrasekar, B | 1 |
| Lipka, S | 1 |
| Kumar, A | 1 |
| Richter, JE | 1 |
| Lu, Y | 1 |
| Yue-Meng, W | 1 |
| Li, YH | 1 |
| Wu, HM | 1 |
| Yang, J | 1 |
| Yang, LH | 1 |
| Xu, Y | 1 |
| Liu, PP | 1 |
| Liu, HH | 1 |
| Sun, SH | 1 |
| Shi, XX | 1 |
| Yang, WC | 1 |
| Su, GH | 1 |
| Zhao, J | 1 |
| Abegunewardene, N | 1 |
| Schmidt, KH | 1 |
| Vosseler, M | 1 |
| Kreitner, KF | 1 |
| Schreiber, LM | 1 |
| Lehr, HA | 1 |
| Gori, T | 1 |
| Münzel, T | 1 |
| Horstick, G | 1 |
| Wu, R | 1 |
| Yin, D | 1 |
| Sadekova, N | 1 |
| Deschepper, CF | 1 |
| de Champlain, J | 1 |
| Girouard, H | 1 |
| Murphy, GJ | 1 |
| Waller, JR | 1 |
| Sandford, RS | 1 |
| Furness, PN | 1 |
| Nicholson, ML | 1 |
| Breyer, MD | 1 |
| Fischer, C | 1 |
| Wöhrle, J | 1 |
| Pastor, J | 1 |
| Morgenroth, K | 1 |
| Senge, T | 1 |
| Assy, N | 1 |
| Hussein, O | 1 |
| Khalil, A | 1 |
| Luder, A | 1 |
| Szvalb, S | 1 |
| Paizi, M | 1 |
| Spira, G | 1 |
| Haneda, N | 1 |
| Mori, C | 1 |
| Pearl, JM | 1 |
| Laks, H | 1 |
| Barthell, S | 1 |
| Drinkwater, DC | 1 |
| Capouya, ER | 1 |
| Chang, PA | 1 |
| Kalkman, EA | 1 |
| van Suylen, RJ | 1 |
| van Dijk, JP | 1 |
| Saxena, PR | 1 |
| Schoemaker, RG | 1 |
| Fong, DS | 1 |
| Segal, PP | 1 |
| Myers, F | 1 |
| Ferris, FL | 1 |
| Hubbard, LD | 1 |
| Davis, MD | 1 |
| Boerboom, LE | 1 |
| Olinger, GN | 1 |
| Liu, TZ | 1 |
| Rodriguez, ER | 1 |
| Ferrans, VJ | 1 |
| Kissebah, AH | 1 |
3 trials available for aspirin and Cirrhosis
| Article | Year |
|---|---|
Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis.
Topics: Adult; Analysis of Variance; Aspirin; Cyclosporine; Extracellular Matrix; Female; Fibrosis; Graft Re | 2003 |
Histopathologic and coronary angiographic assessment of effectiveness of aspirin or aspirin-and-gammaglobulin in Kawasaki disease.
Topics: Acute Disease; Aspirin; Biopsy; Cardiomyopathies; Child; Child, Preschool; Coronary Aneurysm; Corona | 1993 |
Subretinal fibrosis in diabetic macular edema. ETDRS report 23. Early Treatment Diabetic Retinopathy Study Research Group.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetic Retinopathy; Exudates and Transudates; Fi | 1997 |
25 other studies available for aspirin and Cirrhosis
| Article | Year |
|---|---|
Ventricular longitudinal shortening is an independent predictor of death in heart failure patients with reduced ejection fraction.
Topics: Aged; Aspirin; Body Mass Index; Cicatrix; Diuretics; Female; Fibrosis; Follow-Up Studies; Heart Fail | 2021 |
Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery.
Topics: Aspirin; Cell Transdifferentiation; Cells, Cultured; Chromatography, Liquid; Cicatrix; Collagen; Cyt | 2022 |
Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials.
Topics: Aspirin; Carcinoma, Hepatocellular; Fibrosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors | 2023 |
Ticagrelor Improves Remodeling, Reduces Apoptosis, Inflammation and Fibrosis and Increases the Number of Progenitor Stem Cells After Myocardial Infarction in a Rat Model of Ischemia Reperfusion.
Topics: Animals; Apoptosis; Aspirin; Atrial Natriuretic Factor; Disease Models, Animal; Drug Therapy, Combin | 2019 |
Daily Aspirin Use Associated With Reduced Risk for Fibrosis Progression in Patients With Nonalcoholic Fatty Liver Disease.
Topics: Aspirin; Disease Progression; Fibrosis; Humans; Liver Cirrhosis; Non-alcoholic Fatty Liver Disease | 2020 |
Aspirin inhibits endometrial fibrosis by suppressing the TGF‑β1‑Smad2/Smad3 pathway in intrauterine adhesions.
Topics: Adult; Aspirin; Endometrium; Estrogens; Female; Fibrosis; Humans; Neovascularization, Pathologic; Re | 2020 |
Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Arrhythmia Agents; Aspirin; Atrial Fibrillation; Atrial | 2021 |
Low-dose Aspirin prevents hypertension and cardiac fibrosis when thromboxane A
Topics: Adult; Animals; Antifibrotic Agents; Antihypertensive Agents; Aspirin; Biomarkers; Blood Platelets; | 2021 |
Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways.
Topics: Actins; Angiotensin II; Animals; Aspirin; beta Catenin; Cell Line; Collagen Type I; Disease Models, | 2018 |
Novel reno-protective mechanism of Aspirin involves H2AK119 monoubiquitination and Set7 in preventing type 1 diabetic nephropathy.
Topics: Animals; Aspirin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies | 2018 |
Reply.
Topics: Aspirin; Disease Progression; Fibrosis; Humans; Non-alcoholic Fatty Liver Disease | 2020 |
Cutaneous involvement by post-polycythemia vera myelofibrosis.
Topics: Aged; Aspirin; Biopsy; Cell Lineage; Disease Progression; Drug Therapy, Combination; Fibrosis; Hemat | 2014 |
Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK.
Topics: Animals; Aspirin; Biomarkers, Tumor; Cell Line; Cell Movement; Collagen; Drug Combinations; Fibrobla | 2014 |
Impact of Diagnostic Delay and Other Risk Factors on Eosinophilic Esophagitis Phenotype and Esophageal Diameter.
Topics: Adult; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chi-Square Distribution; | 2016 |
Letter: would aspirin alleviate fibrosis in alcoholic liver disease?
Topics: Aspirin; Fibrosis; Humans; Liver; Liver Cirrhosis, Alcoholic; Liver Diseases, Alcoholic | 2016 |
Portal Vein Thrombosis in Patients With Cirrhosis Undergoing Elective Transjugular Intrahepatic Portosystemic Shunt: Risk Factors, Warfarin Efficacy, and Clinical Outcomes.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Elective Surgical Procedures; Female; Fibrosis | 2018 |
Aspirin alleviates cardiac fibrosis in mice by inhibiting autophagy.
Topics: Animals; Apoptosis; Aspirin; Autophagy; Cardiomyopathies; Cardiotonic Agents; Cell Hypoxia; Fibrobla | 2017 |
Gene therapy with iNOS enhances regional contractility and reduces delayed contrast enhancement in a model of postischemic congestive heart failure.
Topics: Animals; Anticoagulants; Aspirin; Clopidogrel; Contrast Media; Coronary Angiography; Coronary Stenos | 2011 |
Protective effects of aspirin from cardiac hypertrophy and oxidative stress in cardiomyopathic hamsters.
Topics: Animals; Aorta; Aspirin; Blood Pressure; Body Weight; Cardiomegaly; Cardiomyopathies; Cardiotonic Ag | 2012 |
Getting to the heart of COX-2 inhibition.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Blood Pressure; | 2005 |
[Extracorporeal shock-wave lithotripsy induced ultrastructural changes to the renal parenchyma under aspirin use. Electron microscopic findings in the rat kidney].
Topics: Animals; Apoptosis; Aspirin; Capillary Fragility; Fibrinolytic Agents; Fibrosis; Hematoma; Kidney; K | 2007 |
The beneficial effect of aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of cirrhosis.
Topics: Animals; Aspartate Aminotransferases; Aspirin; Bilirubin; Disease Progression; Enoxaparin; Fibrinoly | 2007 |
Spontaneous closure of fenestrations in an interatrial Gore-Tex patch: application to the Fontan procedure.
Topics: Animals; Aspirin; Blood Platelets; Blood Vessel Prosthesis; Cardiac Surgical Procedures; Dogs; Fibro | 1994 |
Chronic aspirin treatment affects collagen deposition in non-infarcted myocardium during remodeling after coronary artery ligation in the rat.
Topics: Animals; Aspirin; Collagen; Coronary Vessels; Dose-Response Relationship, Drug; Eicosanoids; Endothe | 1995 |
Histologic, morphometric, and biochemical evolution of vein bypass grafts in a nonhuman primate model. III. Long-term changes and their modification by platelet inhibition with aspirin and dipyridamole.
Topics: Animals; Aspirin; Cholesterol; Dipyridamole; Drug Administration Schedule; Endothelium, Vascular; Fe | 1990 |