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aspirin and Choline Deficiency

aspirin has been researched along with Choline Deficiency in 3 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Choline Deficiency: A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)

Research Excerpts

ExcerptRelevanceReference
"All three antiplatelet drugs, namely aspirin, ticlopidine and cilostazol, significantly attenuated liver steatosis, inflammation and fibrosis in the CDAA diet group."3.74Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease. ( Abe, Y; Endo, H; Fujita, K; Inamori, M; Iwasaki, T; Kirikoshi, H; Kobayashi, N; Kubota, K; Nagashima, Y; Nakajima, A; Nozaki, Y; Saito, S; Takahashi, H; Wada, K; Yoneda, M, 2008)
"Effects of inhibitors of arachidonic acid (AA) metabolism on the development of fatty liver, cirrhosis, glutathione-S-transferase placental form (GST-P)-positive nodules and the generation of 8-hydroxydeoxyguanosine (8-OHdG) and thiobarbituric acid-reactive substances (TBARS), caused by a choline-deficient, L-amino acid-defined (CDAA) diet, were examined in male Fischer 344 rats by feeding CDAA diets supplemented with the inhibitors for 12 and 30 weeks."3.69Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats. ( Denda, A; Endoh, T; Horiguchi, K; Kobayashi, E; Konishi, Y; Nakae, D; Noguchi, O; Ogasawara, H; Sugimura, M; Tamura, K; Tang, Q; Tsujiuchi, T, 1996)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fujita, K1
Nozaki, Y1
Wada, K1
Yoneda, M1
Endo, H1
Takahashi, H1
Iwasaki, T1
Inamori, M1
Abe, Y1
Kobayashi, N1
Kirikoshi, H1
Kubota, K1
Saito, S1
Nagashima, Y1
Nakajima, A1
Denda, A2
Tang, Q2
Endoh, T2
Tsujiuchi, T2
Horiguchi, K2
Noguchi, O2
Mizumoto, Y1
Nakae, D2
Konishi, Y2
Kobayashi, E1
Tamura, K1
Ogasawara, H1
Sugimura, M1

Other Studies

3 other studies available for aspirin and Choline Deficiency

ArticleYear
Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease.
    Gut, 2008, Volume: 57, Issue:11

    Topics: Alanine Transaminase; Animals; Aspirin; Cholesterol; Choline Deficiency; Cilostazol; Dietary Fats; D

2008
Prevention by acetylsalicylic acid of liver cirrhosis and carcinogenesis as well as generations of 8-hydroxydeoxyguanosine and thiobarbituric acid-reactive substances caused by a choline-deficient, L-amino acid-defined diet in rats.
    Carcinogenesis, 1994, Volume: 15, Issue:6

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Amino Acids; Animals; Arachidonic Acid; Aspirin; Choline Deficiency; De

1994
Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats.
    Carcinogenesis, 1996, Volume: 17, Issue:3

    Topics: Acetophenones; Animals; Aspirin; Choline; Choline Deficiency; Cyclooxygenase Inhibitors; Fatty Liver

1996