Page last updated: 2024-10-23

aspirin and Cholelithiasis

aspirin has been researched along with Cholelithiasis in 23 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Cholelithiasis: Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS).

Research Excerpts

ExcerptRelevanceReference
"Data from 4524 patients in a randomized, controlled trial of aspirin were analyzed to determine if aspirin reduced the risk for hospitalization for gallstone disease."9.07One gram of aspirin per day does not reduce risk of hospitalization for gallstone disease. ( Abbey, D; Kurata, JH; Marks, J, 1991)
"The effect of aspirin on cholesterol cholelithiasis was examined in the hamster and the prairie dog."7.68Aspirin does not inhibit cholesterol cholelithiasis in two established animal models. ( Ayyad, N; Cohen, BI; McSherry, CK; Mosbach, EH; Yoshii, M, 1991)
"Patients with gallstone disease have impaired gallbladder motility."6.68Effect of aspirin on gallbladder motility in patients with gallstone disease. A randomized, double-blind, placebo-controlled trial of two dosage schedules. ( Baijal, SS; Das, A; Saraswat, VA, 1995)
"Data from 4524 patients in a randomized, controlled trial of aspirin were analyzed to determine if aspirin reduced the risk for hospitalization for gallstone disease."5.07One gram of aspirin per day does not reduce risk of hospitalization for gallstone disease. ( Abbey, D; Kurata, JH; Marks, J, 1991)
" All patients were contacted for ultrasonography and were interviewed for additional information on daily intake of aspirin, NSAIDs, cholesterol lowering medication, estrogen therapy, and biliary pain during follow-up."3.70Gallstone recurrence after successful shock wave therapy: the magnitude of the problem and the predictive factors. ( Afschrift, M; Cesmeli, E; De Buyzere, M; Elewaut, A; Elewaut, AE; Kerre, T, 1999)
"The effect of aspirin on cholesterol cholelithiasis was examined in the hamster and the prairie dog."3.68Aspirin does not inhibit cholesterol cholelithiasis in two established animal models. ( Ayyad, N; Cohen, BI; McSherry, CK; Mosbach, EH; Yoshii, M, 1991)
"Patients with gallstone disease have impaired gallbladder motility."2.68Effect of aspirin on gallbladder motility in patients with gallstone disease. A randomized, double-blind, placebo-controlled trial of two dosage schedules. ( Baijal, SS; Das, A; Saraswat, VA, 1995)
"In the aspirin group the recurrence rate was 18."2.67Can aspirin prevent gallstone recurrence after successful extracorporeal shockwave lithotripsy? ( Adamek, HE; Buttmann, A; Riemann, JF; Weber, J, 1994)
"Treatment with aspirin led to a significant reduction in mucus biosynthesis by the gall bladder mucosa."2.67Inhibition of human gall bladder mucus synthesis in patients undergoing cholecystectomy. ( Allen, A; Dowling, RH; Lennard, TW; Murphy, G; Rhodes, M, 1992)
"With aspirin, there was no change in deoxycholate but a decrease in arachidonate and no change in glycoprotein."2.67Roles of deoxycholate and arachidonate in pathogenesis of cholesterol gallstones in obese patients during rapid loss of weight. ( Bonorris, GG; Marks, JW; Schoenfield, LJ, 1991)
"In the United States, pancreatic cancer is the 4(th) leading cause of cancer death, and in Europe it is the 6th."2.42Epidemiology of pancreatic cancer. ( Michaud, DS, 2004)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19908 (34.78)18.7374
1990's14 (60.87)18.2507
2000's1 (4.35)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Michaud, DS1
Smith, BF1
LaMont, JT2
Kupfer, RM1
Northfield, TC1
Lee, SP1
Carey, MC1
Das, A1
Baijal, SS1
Saraswat, VA1
Borch, K1
Chu, M1
Kullman, E1
Carlsson, B1
Rehfeld, JF1
Adamek, HE1
Buttmann, A1
Weber, J1
Riemann, JF1
Kam, DM1
Webb, PA1
Sandman, G1
Chugh, A1
Vertz, ML1
Scheeres, DE1
Sahlin, S1
MacPherson, BR1
Pemsingh, RS1
Sterling, RK1
Shiffman, ML1
Cesmeli, E1
Elewaut, AE1
Kerre, T1
De Buyzere, M1
Afschrift, M1
Elewaut, A1
Méndez-Sánchez, N1
Lizardi-Cervera, J1
Morán, S1
Uribe, M1
Rhodes, M1
Allen, A1
Dowling, RH2
Murphy, G1
Lennard, TW1
Cohen, BI1
Mosbach, EH1
Ayyad, N1
Yoshii, M1
McSherry, CK1
Kurata, JH1
Marks, J1
Abbey, D1
Marks, JW2
Bonorris, GG2
Schoenfield, LJ2
Xu, Z1
Hood, K1
Gleeson, D1
Ruppin, DC1
Broomfield, PH1
Chopra, R1
Sheinbaum, RC1
Silverman, A1
Besançon, F2
Marche, C2
Barret, C1
Parrot, J1

Reviews

1 review available for aspirin and Cholelithiasis

ArticleYear
Epidemiology of pancreatic cancer.
    Minerva chirurgica, 2004, Volume: 59, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cholecystectomy; Cholelithiasis; Chronic Disease;

2004

Trials

8 trials available for aspirin and Cholelithiasis

ArticleYear
Effect of sodium acetyl salicylate on cholesterol saturation of fasting gall bladder bile, with and without chenic acid.
    British journal of clinical pharmacology, 1983, Volume: 15, Issue:1

    Topics: Aged; Aspirin; Bile; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Female; Gallbladder; Humans

1983
Effect of aspirin on gallbladder motility in patients with gallstone disease. A randomized, double-blind, placebo-controlled trial of two dosage schedules.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:8

    Topics: Adult; Aspirin; Cholelithiasis; Double-Blind Method; Drug Administration Schedule; Female; Gallbladd

1995
Can aspirin prevent gallstone recurrence after successful extracorporeal shockwave lithotripsy?
    Scandinavian journal of gastroenterology, 1994, Volume: 29, Issue:4

    Topics: Adult; Aged; Aspirin; Cholelithiasis; Female; Follow-Up Studies; Humans; Life Tables; Lithotripsy; M

1994
Inhibition of human gall bladder mucus synthesis in patients undergoing cholecystectomy.
    Gut, 1992, Volume: 33, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Bile; Cholelithiasis; Cholesterol; Depression, Chemical; Fe

1992
One gram of aspirin per day does not reduce risk of hospitalization for gallstone disease.
    Digestive diseases and sciences, 1991, Volume: 36, Issue:8

    Topics: Adult; Aged; Aspirin; Cholelithiasis; Double-Blind Method; Female; Hospitalization; Humans; Male; Mi

1991
Roles of deoxycholate and arachidonate in pathogenesis of cholesterol gallstones in obese patients during rapid loss of weight.
    Digestive diseases and sciences, 1991, Volume: 36, Issue:7

    Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Cholelithiasis; Cholesterol; Deoxycholic Acid; Dinopro

1991
Prevention of gallstone recurrence by non-steroidal anti-inflammatory drugs.
    Lancet (London, England), 1988, Nov-26, Volume: 2, Issue:8622

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cholelithiasis; Dr

1988
Effects of ursodeoxycholic acid and aspirin on the formation of lithogenic bile and gallstones during loss of weight.
    The New England journal of medicine, 1988, Dec-15, Volume: 319, Issue:24

    Topics: Adult; Aspirin; Bile; Cholelithiasis; Cholesterol; Crystallization; Deoxycholic Acid; Double-Blind M

1988

Other Studies

14 other studies available for aspirin and Cholelithiasis

ArticleYear
The pathogenesis of gallstones.
    Hospital practice (Office ed.), 1984, Volume: 19, Issue:12

    Topics: Animals; Aspirin; Bile; Bile Acids and Salts; Cholelithiasis; Cholesterol; Cricetinae; Crystallizati

1984
Aspirin prevention of cholesterol gallstone formation in prairie dogs.
    Science (New York, N.Y.), 1981, Mar-27, Volume: 211, Issue:4489

    Topics: Animals; Aspirin; Bile; Cholelithiasis; Cholesterol, Dietary; Crystallization; Culture Techniques; G

1981
Endogenous hypercholecystokininemia, but not aspirin, reduces the gallstone incidence in the hamster model.
    Scandinavian journal of gastroenterology, 1994, Volume: 29, Issue:8

    Topics: Animals; Aspirin; Biliopancreatic Diversion; Cholecystokinin; Cholelithiasis; Cricetinae; Diet; Male

1994
A novel 5-lipoxygenase inhibitor prevents gallstone formation in a lithogenic prairie dog model.
    The American surgeon, 1996, Volume: 62, Issue:7

    Topics: Animals; Aspirin; Cholelithiasis; Cholesterol; Cyclooxygenase Inhibitors; Disease Models, Animal; En

1996
Total protein content of human gallbladder bile: relation to cholesterol gallstone disease and effects of treatment with bile acids and aspirin.
    The European journal of surgery = Acta chirurgica, 1996, Volume: 162, Issue:6

    Topics: Aspirin; Bile; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Female; Humans; Lipids; Male; Mid

1996
Ground squirrel model for cholelithiasis: role of epithelial glycoproteins.
    Microscopy research and technique, 1997, Oct-01, Volume: 39, Issue:1

    Topics: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile; Calcium; Cholelithiasi

1997
Nonsteroidal antiinflammatory drugs and gallstone disease: will an aspirin a day keep the gallstones away?
    The American journal of gastroenterology, 1998, Volume: 93, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cholagogues and Choleretics; Cholelithiasis; Chole

1998
Gallstone recurrence after successful shock wave therapy: the magnitude of the problem and the predictive factors.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:2

    Topics: Actuarial Analysis; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile Aci

1999
Cholesterol gallstones and aspirin.
    Gastroenterology, 1992, Volume: 103, Issue:4

    Topics: Animals; Aspirin; Cholelithiasis; Cholesterol; Cricetinae; Disease Models, Animal; Dogs; Male; Mesoc

1992
Aspirin does not inhibit cholesterol cholelithiasis in two established animal models.
    Gastroenterology, 1991, Volume: 101, Issue:4

    Topics: Animals; Aspirin; Bile; Bile Acids and Salts; Cholelithiasis; Cholesterol; Cholesterol, Dietary; Cri

1991
[Changes in bile components during the formation and prevention of black pigment gallstone in a guinea pig model].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 1990, Volume: 28, Issue:9

    Topics: Animals; Aspirin; Bile; Bile Acids and Salts; Bilirubin; Calcium; Cholelithiasis; Glycoproteins; Gui

1990
The treatment of pulmonary embolism.
    Chest, 1973, Volume: 63, Issue:6

    Topics: Adult; Aspirin; Blood Coagulation Tests; Cholelithiasis; Diabetes Complications; Female; Heparin; Hu

1973
[Pathologic and therapeutic similarities between arteriosclerosis and lithiasic cholecystitis].
    Annales de medecine interne, 1971, Volume: 122, Issue:10

    Topics: Acetamides; Aminosalicylic Acids; Animals; Arteriosclerosis; Aspirin; Cholecystitis; Cholelithiasis;

1971
[Experimental therapy of gallbladder lithiasis. Preventive and curative effects of various drugs in mice].
    Archives francaises des maladies de l'appareil digestif, 1970, Volume: 59, Issue:6

    Topics: Animals; Aspirin; Cholelithiasis; Cholestyramine Resin; Clofibrate; Dehydrocholic Acid; Hydantoins;

1970