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aspirin and Cell Transformation, Neoplastic

aspirin has been researched along with Cell Transformation, Neoplastic in 42 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

Research Excerpts

ExcerptRelevanceReference
"Despite being shown to be effective for chemoprevention of colorectal cancer, aspirin has limitations including adverse effects and inability to block colitis-associated colon cancer (CAC)."8.31Combining gamma-tocopherol and aspirin synergistically suppresses colitis-associated colon tumorigenesis and modulates the gut microbiota in mice, and inhibits the growth of human colon cancer cells. ( Jiang, Q; Jones-Hall, Y; Liu, KY; Nakatsu, CH; Wang, Q, 2023)
"Aspirin is a chemopreventive agent for colorectal adenoma and cancer (CRC) that, like many drugs inclusive of chemotherapeutics, has been investigated for its effects on bacterial growth and virulence gene expression."8.02Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum. ( Brennan, CA; Chan, AT; Drew, DA; Gallini Comeau, CA; Garrett, WS; Glickman, JN; Nakatsu, G; Schoen, RE, 2021)
"Regular use of aspirin appears to reduce the risk of colorectal cancers that overexpress COX-2 but not the risk of colorectal cancers with weak or absent expression of COX-2."7.74Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. ( Chan, AT; Fuchs, CS; Ogino, S, 2007)
"Chronic inflammation has long been considered critical in pancreatic carcinogenesis, and recently studies showed that some anti-inflammatory agents such as aspirin could potentially be used to attenuate pancreatic carcinogenesis."4.95Inflammation-Related Pancreatic Carcinogenesis: Mechanisms and Clinical Potentials in Advances. ( Dai, JJ; Jiang, MJ; Tian, L; Wang, XP, 2017)
"Despite being shown to be effective for chemoprevention of colorectal cancer, aspirin has limitations including adverse effects and inability to block colitis-associated colon cancer (CAC)."4.31Combining gamma-tocopherol and aspirin synergistically suppresses colitis-associated colon tumorigenesis and modulates the gut microbiota in mice, and inhibits the growth of human colon cancer cells. ( Jiang, Q; Jones-Hall, Y; Liu, KY; Nakatsu, CH; Wang, Q, 2023)
"Aspirin is a chemopreventive agent for colorectal adenoma and cancer (CRC) that, like many drugs inclusive of chemotherapeutics, has been investigated for its effects on bacterial growth and virulence gene expression."4.02Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum. ( Brennan, CA; Chan, AT; Drew, DA; Gallini Comeau, CA; Garrett, WS; Glickman, JN; Nakatsu, G; Schoen, RE, 2021)
"We identify an aspirin-induced upregulated lncRNA, OLA1P2, in human colorectal cancer."3.83The aspirin-induced long non-coding RNA OLA1P2 blocks phosphorylated STAT3 homodimer formation. ( Ben, Q; Chen, W; Guo, H; Li, M; Liu, J; Qu, Y; Wang, Y; Zhang, J, 2016)
" The protective effects of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) for colorectal cancers in experimental and clinical studies are also demonstrated in this review."3.77[Oncogenesis humoral mechanisms regulation and NSAIDs ability in prevention of tumors]. ( Drozdov, VN; Kim, VA; Lazebnik, LV, 2011)
"Regular use of aspirin appears to reduce the risk of colorectal cancers that overexpress COX-2 but not the risk of colorectal cancers with weak or absent expression of COX-2."3.74Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. ( Chan, AT; Fuchs, CS; Ogino, S, 2007)
"Essential thrombocythemia is a chronic myeloproliferative neoplasm characterized by sustained thrombocytosis, bone marrow megakaryocytic hyperplasia and an increased risk of thrombosis and hemorrhage."2.49[Treatment of essential thrombocythemia]. ( Alvarez-Larrán, A; Besses, C; Cervantes, F, 2013)
"Pancreatic cancer is the most deadly of all gastrointestinal malignancies with near zero five-year survival."2.43NF-kappaB, inflammation and pancreatic carcinogenesis: NF-kappaB as a chemoprevention target (review). ( Rigas, B; Zhang, Z, 2006)
" An initial dosing study performed in healthy mice indicates that aspirin at a dose of 25 mg/kg/d has a similar pharmacodynamic effect as low-dose aspirin treatment in human subjects (100 mg/d)."1.56Effects of chronic low-dose aspirin treatment on tumor prevention in three mouse models of intestinal tumorigenesis. ( Hartung, NM; Kühl, AA; McDonald, FM; Ostermann, AI; Rohwer, N; Schebb, NH; Weylandt, KH; Zopf, D, 2020)
" The two NSAIDs proved to be safe and efficacious in the experimental model used."1.43Selective inhibition by aspirin and naproxen of mainstream cigarette smoke-induced genotoxicity and lung tumors in female mice. ( Balansky, R; D'Oria, C; De Flora, S; Ganchev, G; Iltcheva, M; La Maestra, S; Micale, RT; Steele, VE, 2016)
" We investigated the long-term administration of low dose of aspirin in a model of experimental colon carcinogenesis in rats."1.36Long-term administration of aspirin inhibits tumour formation and triggers anti-neoplastic molecular changes in a pre-clinical model of colon carcinogenesis. ( Bouhadjar, M; Bousserouel, S; Gosse, F; Marescaux, J; Raul, F; Soler, L, 2010)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19905 (11.90)18.7374
1990's3 (7.14)18.2507
2000's15 (35.71)29.6817
2010's14 (33.33)24.3611
2020's5 (11.90)2.80

Authors

AuthorsStudies
Liu, KY1
Wang, Q1
Nakatsu, CH1
Jones-Hall, Y1
Jiang, Q1
Sun, L1
Suo, C1
Zhang, T1
Shen, S1
Gu, X1
Qiu, S1
Zhang, P1
Wei, H1
Ma, W1
Yan, R1
Chen, R1
Jia, W1
Cao, J1
Zhang, H1
Gao, P1
Rohwer, N1
Kühl, AA1
Ostermann, AI1
Hartung, NM1
Schebb, NH1
Zopf, D1
McDonald, FM1
Weylandt, KH1
Brennan, CA1
Nakatsu, G1
Gallini Comeau, CA1
Drew, DA1
Glickman, JN1
Schoen, RE1
Chan, AT2
Garrett, WS1
Feng, Y1
Tao, L1
Wang, G1
Li, Z1
Yang, M1
He, W1
Zhong, X1
Zhang, Y1
Yang, J1
Cheung, S1
McDonald, F1
Chen, L1
Dai, JJ1
Jiang, MJ1
Wang, XP1
Tian, L1
Bhardwaj, A1
Singh, H1
Trinidad, CM1
Albarracin, CT1
Hunt, KK1
Bedrosian, I1
Moeini, A1
Torrecilla, S1
Tovar, V1
Montironi, C1
Andreu-Oller, C1
Peix, J1
Higuera, M1
Pfister, D1
Ramadori, P1
Pinyol, R1
Solé, M1
Heikenwälder, M1
Friedman, SL1
Sia, D1
Llovet, JM1
Bain, BJ1
Garnett, C1
Deplano, S1
Naresh, K1
Kanfer, E1
Alvarez-Larrán, A1
Cervantes, F1
Besses, C1
Wang, R1
Wang, Y2
Gao, Z1
Qu, X1
Balansky, R1
Ganchev, G1
Iltcheva, M1
Micale, RT1
La Maestra, S1
D'Oria, C1
Steele, VE2
De Flora, S1
Guo, H1
Liu, J1
Ben, Q1
Qu, Y1
Li, M1
Chen, W1
Zhang, J1
Clouser, MC1
Roe, DJ1
Foote, JA1
Harris, RB1
Bousserouel, S1
Gosse, F2
Bouhadjar, M2
Soler, L2
Marescaux, J2
Raul, F2
Hsieh, CC1
Hernández-Ledesma, B1
de Lumen, BO1
Femia, AP1
Salvianti, F1
Luceri, C1
Dolara, P1
Salvadori, M1
Pinzani, P1
Caderni, G1
Maxwell, PH1
Kim, VA1
Lazebnik, LV1
Drozdov, VN1
Rao, CV1
Mohammed, A1
Janakiram, NB1
Li, Q1
Ritchie, RL1
Lightfoot, S1
Vibhudutta, A1
Caine, GJ1
Kehoe, ST1
Lip, GY1
Bair, WB1
Hart, N1
Einspahr, J1
Liu, G1
Dong, Z3
Alberts, D1
Bowden, GT1
Funk, JO1
Ghezzo, F1
Cesano, L1
Mognetti, B1
Pesce, E1
Pirro, E1
Corvetti, G1
Berta, GN1
Zingaro, B1
Di Carlo, F1
Ouyang, N1
Williams, JL1
Rigas, B2
Zhang, Z1
Moral, MA1
Khurdayan, VK1
Bozzo, J1
Ogino, S1
Fuchs, CS1
Markowitz, SD1
Osswald, AB1
Foltzer-Jourdainne, C1
Jiménez, P1
García, A1
Santander, S1
Piazuelo, E1
Mehta, P1
Grignani, G1
Pacchiarini, L1
Almasio, P1
Pagliarino, M1
Gamba, G1
Huang, C1
Brown, RE1
Ma, WY1
Morgan, G1
Goodsell, DS1
Shimamura, T1
Hsu, TC1
Colburn, NH1
Bejcek, BE1
Bode, AM1
Claesson, HE1
Lindgren, JA1
Hammarström, S1
St John, DJ1
Yeomans, ND1
Bourne, CA1
de Boer, WG1
Radner, BS1
Kennedy, AR1
Patierno, SR1
Lehman, NL1
Henderson, BE1
Landolph, JR1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
0822GCC Randomized, Double-Blind, Placebo-Controlled Multicenter Phase 2 Study of the Efficacy and Safety of Apricoxib in Combination With Either Docetaxel or Pemetrexed in Non-Small Cell Lung Cancer Patients[NCT00771953]Phase 2109 participants (Actual)Interventional2008-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Progression Free Survival

For determining progression-free survival, progression was determined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0). Progression was defined as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions. (NCT00771953)
Timeframe: From the date of randomization until the first date that recurrent or progressive disease is objectively documented.

Interventiondays (Median)
Apricoxib Plus Docetaxel75
Placebo Plus Docetaxel97
Apricoxib Plus Pemetrexed103
Placebo Plus Pemetrexed98

Reviews

7 reviews available for aspirin and Cell Transformation, Neoplastic

ArticleYear
Inflammation-Related Pancreatic Carcinogenesis: Mechanisms and Clinical Potentials in Advances.
    Pancreas, 2017, Volume: 46, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Transformation, Neoplastic; Humans;

2017
[Treatment of essential thrombocythemia].
    Medicina clinica, 2013, Sep-21, Volume: 141, Issue:6

    Topics: Adult; Age Factors; Aged; Anticoagulants; Aspirin; Cell Transformation, Neoplastic; Disease Progress

2013
NF-kappaB, inflammation and pancreatic carcinogenesis: NF-kappaB as a chemoprevention target (review).
    International journal of oncology, 2006, Volume: 29, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Aspirin; Cell Pr

2006
Chronicles in drug discovery.
    Drug news & perspectives, 2006, Volume: 19, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Budesonide; Cell

2006
Prevention of cancer in the upper gastrointestinal tract with COX-inhibition. Still an option?
    Current pharmaceutical design, 2007, Volume: 13, Issue:22

    Topics: Adenocarcinoma; Anticarcinogenic Agents; Aspirin; Cardiovascular Diseases; Cell Transformation, Neop

2007
Potential role of platelets in the pathogenesis of tumor metastasis.
    Blood, 1984, Volume: 63, Issue:1

    Topics: Animals; Aspirin; Blood Platelets; Capillary Permeability; Cell Transformation, Neoplastic; Endothel

1984
Signal transduction pathways: targets for chemoprevention of skin cancer.
    The Lancet. Oncology, 2000, Volume: 1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Cell Transformat

2000

Trials

1 trial available for aspirin and Cell Transformation, Neoplastic

ArticleYear
Effect of non-steroidal anti-inflammatory drugs on non-melanoma skin cancer incidence in the SKICAP-AK trial.
    Pharmacoepidemiology and drug safety, 2009, Volume: 18, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Arizona; Aspirin; Carcinoma, Basal

2009

Other Studies

34 other studies available for aspirin and Cell Transformation, Neoplastic

ArticleYear
Combining gamma-tocopherol and aspirin synergistically suppresses colitis-associated colon tumorigenesis and modulates the gut microbiota in mice, and inhibits the growth of human colon cancer cells.
    European journal of pharmacology, 2023, May-05, Volume: 946

    Topics: Animals; Aspirin; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colonic Ne

2023
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
    Nature chemical biology, 2023, Volume: 19, Issue:12

    Topics: Arachidonic Acid; Aspirin; Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Cell Proliferation;

2023
Effects of chronic low-dose aspirin treatment on tumor prevention in three mouse models of intestinal tumorigenesis.
    Cancer medicine, 2020, Volume: 9, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Azoxymethane; Carcinogens; Cel

2020
Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum.
    mBio, 2021, 04-06, Volume: 12, Issue:2

    Topics: Adenoma; Animals; Aspirin; Bacteria; Carcinogenesis; Cell Transformation, Neoplastic; Colon; Colorec

2021
Aspirin inhibits prostaglandins to prevents colon tumor formation via down-regulating Wnt production.
    European journal of pharmacology, 2021, Sep-05, Volume: 906

    Topics: Animals; Aspirin; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colitis-Associated Neoplas

2021
The isomiR-140-3p-regulated mevalonic acid pathway as a potential target for prevention of triple negative breast cancer.
    Breast cancer research : BCR, 2018, 12-11, Volume: 20, Issue:1

    Topics: Animals; Aspirin; Biomarkers, Tumor; Biosynthetic Pathways; Cell Line, Tumor; Cell Transformation, N

2018
An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents.
    Gastroenterology, 2019, Volume: 157, Issue:5

    Topics: Animals; Anticarcinogenic Agents; Aspirin; Biomarkers, Tumor; Carcinoma, Hepatocellular; Case-Contro

2019
Dysplasia of all granulocyte lineages in myelodysplastic evolution of essential thrombocythemia.
    American journal of hematology, 2013, Volume: 88, Issue:5

    Topics: Aged; Amino Acid Substitution; Antineoplastic Agents; Aspirin; Bone Marrow; Cell Lineage; Cell Trans

2013
The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC(Min/+) mice.
    Drug discoveries & therapeutics, 2014, Volume: 8, Issue:1

    Topics: Adenocarcinoma; Adenomatous Polyposis Coli; Administration, Oral; Animals; Anti-Inflammatory Agents;

2014
Selective inhibition by aspirin and naproxen of mainstream cigarette smoke-induced genotoxicity and lung tumors in female mice.
    Archives of toxicology, 2016, Volume: 90, Issue:5

    Topics: Animals; Anticarcinogenic Agents; Aspirin; Cell Transformation, Neoplastic; Cyclooxygenase Inhibitor

2016
The aspirin-induced long non-coding RNA OLA1P2 blocks phosphorylated STAT3 homodimer formation.
    Genome biology, 2016, Feb-22, Volume: 17

    Topics: Animals; Apoptosis; Aspirin; Cell Line, Tumor; Cell Transformation, Neoplastic; Colorectal Neoplasms

2016
Long-term administration of aspirin inhibits tumour formation and triggers anti-neoplastic molecular changes in a pre-clinical model of colon carcinogenesis.
    Oncology reports, 2010, Volume: 23, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Azoxymethane; Carc

2010
Lunasin-aspirin combination against NIH/3T3 cells transformation induced by chemical carcinogens.
    Plant foods for human nutrition (Dordrecht, Netherlands), 2011, Volume: 66, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Anacardic Acids; Animals; Anticarcinogenic Agents; Antineoplastic

2011
Sustained proliferation and resistance to apoptosis after a cytotoxic insult are early alterations in rat colon carcinogenesis.
    International journal of cancer, 2012, Aug-01, Volume: 131, Issue:3

    Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Aspirin; bcl-2 Homologous Antagonist-Killer Protein; Biom

2012
Tumor strengths and frailties: Aspiring to prevent colon cancer.
    Nature medicine, 2012, Jan-06, Volume: 18, Issue:1

    Topics: Aspirin; Cell Transformation, Neoplastic; Colonic Neoplasms; Colorectal Neoplasms, Hereditary Nonpol

2012
[Oncogenesis humoral mechanisms regulation and NSAIDs ability in prevention of tumors].
    Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2011, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Transformation, Neoplastic; Colorectal Neopla

2011
Inhibition of pancreatic intraepithelial neoplasia progression to carcinoma by nitric oxide-releasing aspirin in p48(Cre/+)-LSL-Kras(G12D/+) mice.
    Neoplasia (New York, N.Y.), 2012, Volume: 14, Issue:9

    Topics: Animals; Anticarcinogenic Agents; Aspirin; beta Catenin; Body Weight; Carcinoma in Situ; Carcinoma,

2012
The role of aspirin in carcinogenesis.
    British journal of cancer, 2002, Nov-18, Volume: 87, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arylsulfotransferase; Aspirin; Carcinogens; Cell T

2002
Inhibitory effects of sodium salicylate and acetylsalicylic acid on UVB-induced mouse skin carcinogenesis.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2002, Volume: 11, Issue:12

    Topics: Administration, Topical; Animals; Anticarcinogenic Agents; Aspirin; Biopsy, Needle; Cell Transformat

2002
[Aspirin against cylindromatosis? Molecular functions of the CYLD tumor suppressor].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2004, Volume: 55, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Carcinoma, Adenoid Cystic; Cell Transfo

2004
Salicylate inhibition of rat mammary carcinogenesis and angiogenesis in female rat compatible with misoprostol administration.
    International journal of oncology, 2005, Volume: 26, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Transformation, Neoplastic; Disease

2005
NO-donating aspirin isomers downregulate peroxisome proliferator-activated receptor (PPAR)delta expression in APC(min/+) mice proportionally to their tumor inhibitory effect: Implications for the role of PPARdelta in carcinogenesis.
    Carcinogenesis, 2006, Volume: 27, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Cell Proliferation; Cell Trans

2006
Aspirin and the risk of colorectal cancer in relation to the expression of COX-2.
    The New England journal of medicine, 2007, May-24, Volume: 356, Issue:21

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Transformation, Neoplastic; Cohort Studies; C

2007
Aspirin and colon cancer--targeting prevention?
    The New England journal of medicine, 2007, May-24, Volume: 356, Issue:21

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Transformation, Neoplastic; Colorectal Neopla

2007
Follow-up of tumor development in the colons of living rats and implications for chemoprevention trials: assessment of aspirin-difluoromethylornithine combination.
    International journal of oncology, 2007, Volume: 31, Issue:1

    Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspi

2007
Activation of platelet prostaglandin biosynthesis pathway during neoplastic cell-induced platelet aggregation.
    Thrombosis research, 1984, Apr-15, Volume: 34, Issue:2

    Topics: Animals; Apyrase; Aspirin; Blood Platelets; Cell Line; Cell Transformation, Neoplastic; Fibrosarcoma

1984
Inhibition of activator protein 1 activity and neoplastic transformation by aspirin.
    The Journal of biological chemistry, 1997, Apr-11, Volume: 272, Issue:15

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aspirin; Calcium-Calmodulin-Depende

1997
Correspondence re: R. Kim et al., Etiology of Barrett's metaplasia and esophageal adenocarcinoma. Cancer Epidemiol., Biomark. Prev., 6: 369-377, 1997.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1998, Volume: 7, Issue:3

    Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Barrett Esophagus; Cell Transforma

1998
The molecular perspective: cyclooxygenase-2.
    The oncologist, 2000, Volume: 5, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Transformation, Neoplastic; Cyclooxygenase 2;

2000
Activation of NF-kappaB is required for PDGF-B chain to transform NIH3T3 cells.
    Experimental cell research, 2002, Mar-10, Volume: 274, Issue:1

    Topics: 3T3 Cells; Animals; Aspirin; Cell Transformation, Neoplastic; I-kappa B Proteins; Mice; Mutation; NF

2002
Prostaglandin E2 production in 3T3 cells transformed by polyoma virus raises the intracellular adenosine 3':5'-monophosphate levels.
    European journal of biochemistry, 1977, Mar-15, Volume: 74, Issue:1

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Aspirin; Cell Line; Cell Transformation, Neoplastic; Cyclic AMP; In

1977
Aspirin-induced glandular dysplasia of the stomach: histologic and histochemical studies in rats.
    Archives of pathology & laboratory medicine, 1977, Volume: 101, Issue:1

    Topics: Animals; Aspirin; Cell Transformation, Neoplastic; Female; Gastric Mucosa; Pyloric Antrum; Rats; Sto

1977
Suppression of x-ray induced transformation by Valium and aspirin in mouse C3H10T1/2 cells.
    Cancer letters, 1990, May-15, Volume: 51, Issue:1

    Topics: Animals; Aspirin; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Diazepam; Dose-Response

1990
Study of the ability of phenacetin, acetaminophen, and aspirin to induce cytotoxicity, mutation, and morphological transformation in C3H/10T1/2 clone 8 mouse embryo cells.
    Cancer research, 1989, Feb-15, Volume: 49, Issue:4

    Topics: Acetaminophen; Animals; Aspirin; Biotransformation; Cell Survival; Cell Transformation, Neoplastic;

1989