aspirin has been researched along with Cataract in 75 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the development of age-related cataract in a trial of beta carotene supplementation in men." | 9.10 | A randomized trial of beta carotene and age-related cataract in US physicians. ( Buring, JE; Christen, WG; Gaziano, JM; Glynn, RJ; Hennekens, CH; Manson, JE; Sperduto, RD, 2003) |
| "In Physicians' Health Study I, randomized trial results indicated no major beneficial effect of 5 years of low-dose aspirin treatment on total cataract (relative risk [RR], 0." | 9.09 | Aspirin use and risk of cataract in posttrial follow-up of Physicians' Health Study I. ( Ajani, UA; Christen, WG; Glynn, RJ; Hennekens, CH; Manson, JE; Schaumberg, DA, 2001) |
| "To examine whether low-dose aspirin (325 mg on alternate days) reduces the risk of age-related cataract and subtypes." | 9.08 | Low-dose aspirin and risk of cataract and subtypes in a randomized trial of U.S. physicians. ( Ajani, UA; Buring, JE; Christen, WG; Glynn, RJ; Hennekens, CH; Manson, JE; Schaumberg, DA; Sperduto, RD, 1998) |
| "The Early Treatment Diabetic Retinopathy Study, a randomized clinical trial supported by the National Eye Institute, was designed to assess the effect of photocoagulation and aspirin in 3711 patients with mild to severe nonproliferative or early proliferative diabetic retinopathy." | 9.07 | Aspirin effects on the development of cataracts in patients with diabetes mellitus. Early treatment diabetic retinopathy study report 16. ( Barton, FB; Burton, TC; Chew, EY; Ferris, FL; Remaley, NA; Williams, GA, 1992) |
| "Observational studies have raised the question of a possible benefit of aspirin on the development of cataract." | 9.07 | Low-dose aspirin and risks of cataract in a randomized trial of US physicians. ( Buring, JE; Christen, WG; Hennekens, CH; Manson, JE; Seddon, JM; Sperduto, RD, 1991) |
| "Our outcomes indicated that phacoemulsification cataract surgery using a clear corneal incision with topical anesthesia could be safely done without stopping dual antiplatelet therapy with aspirin and clopidogrel." | 7.96 | Combined aspirin and clopidogrel therapy in phacoemulsification cataract surgery: a risk factor for ocular hemorrhage? ( Jiang, J; Li, Q; Qian, Y; Shen, X; Su, T; Wang, S; Wang, Z; Yan, K; Zhang, P; Zhang, Y, 2020) |
| "The high level of dehydroascorbic acid (DHA) in the lenticular tissue is an important risk factor for the development of age-related cataracts." | 7.85 | Protective effects of carnosine on dehydroascorbate-induced structural alteration and opacity of lens crystallins: important implications of carnosine pleiotropic functions to combat cataractogenesis. ( Hosseinkhani, S; Javadi, S; Tamaddon, AM; Uversky, VN; Yousefi, R, 2017) |
| "The results indicated that carnosine, aspirin, and a combination eye drops are effective against the onset and development of diabetic cataract in rats." | 7.75 | Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats. ( Harding, JJ; Li, MY; Shi, Q; Yan, H, 2009) |
| "To investigate the effect of carnosine (CA), aminoguanidine (AG), and aspirin (ASA) drops, all inhibitors of glycation, on the development of diabetic cataract in rat." | 7.74 | Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats. ( Ding, Z; Guo, Y; Ha, W; Harding, JJ; Yan, H; Zhang, J, 2008) |
| "One hundred and forty-eight lenses were divided into 3 groups and cultured in vitro: control (DMEM), cataract (DMEM + 10 microM dexamethasone), aspirin (DMEM + 10 muM dexamethasone + 2 mM aspirin)." | 7.73 | Protective effect of aspirin against dexamethasone-induced cataract in cultured rat lens. ( Liu, B; Shang, L; Wang, J; Yan, H, 2006) |
| "The role of acetylation in the antiglycating and anticataract effects of aspirin (ASA) is explored by comparing ASA's effects with that of sodium salicylate (SS), a nonacetyl analog of ASA, on cataract development in diabetic rats." | 7.70 | Effect of aspirin and sodium salicylate on cataract development in diabetic rats. ( Kanagasabapathy, AS; Selvakumar, R; Shastri, GV; Thomas, K; Thomas, M; Victoria, AJ, 1998) |
| "Effect of twice daily administration of aspirin eyedrops on the onset and progression of cataract induced by 30% galactose diet was studied." | 7.69 | Topical aspirin provides protection against galactosemic cataract. ( Gupta, SK; Joshi, S; Mathur, P; Tandon, R, 1997) |
| "We examined the association between aspirin use and the rates of cataract extraction during 8 years of follow-up in a large prospective study of women, the Nurses' Health Study." | 7.68 | A prospective study of aspirin use and cataract extraction in women. ( Colditz, GA; Hankinson, SE; Rosner, B; Seddon, JM; Speizer, FE; Stampfer, MJ; Willett, WC, 1993) |
| "Evidence from epidemiological, in vitro and animal studies has accumulated to support the idea that aspirin, ibuprofen and paracetamol protect against cataract." | 7.68 | Prevention of cataract in diabetic rats by aspirin, paracetamol (acetaminophen) and ibuprofen. ( Blakytny, R; Harding, JJ, 1992) |
| "To evaluate the associations between the use of aspirin and the incidences of cardiovascular diseases, cancers, and other chronic diseases." | 7.67 | Aspirin use and chronic diseases: a cohort study of the elderly. ( Chao, A; Henderson, BE; Paganini-Hill, A; Ross, RK, 1989) |
| "Results of a case-control of 423 cataract patients and 608 controls in Oxfordshire shows that the protective effect against cataract associated with consumption of aspirin-like analgesics (aspirin, paracetamol and ibuprofen family) is manifest even at low doses." | 7.67 | Protection against cataract by aspirin, paracetamol and ibuprofen. ( Egerton, M; Harding, JJ; Harding, RS, 1989) |
| " Myopia and the use of nifedipine were found to carry a significant risk of cataract, and renal failure appeared to carry a high risk, though few patients were affected." | 7.67 | Do aspirin-like analgesics protect against cataract? A case-control study. ( Harding, JJ; van Heyningen, R, 1986) |
| "A population-based cross-sectional survey of 838 men aged 30 years and over was conducted to examine the effect of aspirin, and other potential risk factors, on the prevalence of cataracts." | 7.67 | Lack of evidence for aspirin use and prevention of cataracts. ( Emmett, EA; Muñoz, BE; Newland, HS; Taylor, HR; West, SK, 1987) |
| "The prevalence of cataracts is significantly lower in patients with rheumatoid arthritis receiving aspirin (mean of 2,700 mgs daily for an average of 10." | 7.66 | Aspirin effect on cataract formation in patients with rheumatoid arthritis alone or combined with diabetes. ( Cotlier, E, 1981) |
| "Follow-up study of the 214 surviving patients enrolled originally at the Johns Hopkins Clinical Center for the Early Treatment Diabetic Retinopathy Study (ETDRS), which was a clinical trial designed to evaluate the role of laser photocoagulation and aspirin treatment in patients with diabetic retinopathy." | 5.10 | The long-term effects of laser photocoagulation treatment in patients with diabetic retinopathy: the early treatment diabetic retinopathy follow-up study. ( Agrón, E; Chew, EY; Csaky, KG; Ferris, FL; Murphy, RP; Reed, GF; Schachat, AP; Thompson, DJ, 2003) |
| "To examine the development of age-related cataract in a trial of beta carotene supplementation in men." | 5.10 | A randomized trial of beta carotene and age-related cataract in US physicians. ( Buring, JE; Christen, WG; Gaziano, JM; Glynn, RJ; Hennekens, CH; Manson, JE; Sperduto, RD, 2003) |
| "In Physicians' Health Study I, randomized trial results indicated no major beneficial effect of 5 years of low-dose aspirin treatment on total cataract (relative risk [RR], 0." | 5.09 | Aspirin use and risk of cataract in posttrial follow-up of Physicians' Health Study I. ( Ajani, UA; Christen, WG; Glynn, RJ; Hennekens, CH; Manson, JE; Schaumberg, DA, 2001) |
| "A multicenter randomized clinical trial designed to assess the effect of photocoagulation and aspirin in patients with mild to severe nonproliferative or early proliferative diabetic retinopathy and/or macular edema." | 5.09 | Results after lens extraction in patients with diabetic retinopathy: early treatment diabetic retinopathy study report number 25. ( Benson, WE; Burton, TC; Chew, EY; Csaky, K; Ferris, FL; Lindley, AA; Remaley, NA; Williams, GA, 1999) |
| "To examine whether low-dose aspirin (325 mg on alternate days) reduces the risk of age-related cataract and subtypes." | 5.08 | Low-dose aspirin and risk of cataract and subtypes in a randomized trial of U.S. physicians. ( Ajani, UA; Buring, JE; Christen, WG; Glynn, RJ; Hennekens, CH; Manson, JE; Schaumberg, DA; Sperduto, RD, 1998) |
| "The Early Treatment Diabetic Retinopathy Study, a randomized clinical trial supported by the National Eye Institute, was designed to assess the effect of photocoagulation and aspirin in 3711 patients with mild to severe nonproliferative or early proliferative diabetic retinopathy." | 5.07 | Aspirin effects on the development of cataracts in patients with diabetes mellitus. Early treatment diabetic retinopathy study report 16. ( Barton, FB; Burton, TC; Chew, EY; Ferris, FL; Remaley, NA; Williams, GA, 1992) |
| "Observational studies have raised the question of a possible benefit of aspirin on the development of cataract." | 5.07 | Low-dose aspirin and risks of cataract in a randomized trial of US physicians. ( Buring, JE; Christen, WG; Hennekens, CH; Manson, JE; Seddon, JM; Sperduto, RD, 1991) |
| "Our outcomes indicated that phacoemulsification cataract surgery using a clear corneal incision with topical anesthesia could be safely done without stopping dual antiplatelet therapy with aspirin and clopidogrel." | 3.96 | Combined aspirin and clopidogrel therapy in phacoemulsification cataract surgery: a risk factor for ocular hemorrhage? ( Jiang, J; Li, Q; Qian, Y; Shen, X; Su, T; Wang, S; Wang, Z; Yan, K; Zhang, P; Zhang, Y, 2020) |
| "After intravitreal injection of aspirin, no significant toxicity sign was observed other than a reversible cataract." | 3.91 | The safety of intraocular usage of aspirin. ( Arslan, OS; Aydin, O; Dogan, C; Mergen, B; Seymen, HO; Suzer, O; Yetik, H, 2019) |
| "The high level of dehydroascorbic acid (DHA) in the lenticular tissue is an important risk factor for the development of age-related cataracts." | 3.85 | Protective effects of carnosine on dehydroascorbate-induced structural alteration and opacity of lens crystallins: important implications of carnosine pleiotropic functions to combat cataractogenesis. ( Hosseinkhani, S; Javadi, S; Tamaddon, AM; Uversky, VN; Yousefi, R, 2017) |
| "The results indicated that carnosine, aspirin, and a combination eye drops are effective against the onset and development of diabetic cataract in rats." | 3.75 | Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats. ( Harding, JJ; Li, MY; Shi, Q; Yan, H, 2009) |
| "To investigate the effect of carnosine (CA), aminoguanidine (AG), and aspirin (ASA) drops, all inhibitors of glycation, on the development of diabetic cataract in rat." | 3.74 | Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats. ( Ding, Z; Guo, Y; Ha, W; Harding, JJ; Yan, H; Zhang, J, 2008) |
| "One hundred and forty-eight lenses were divided into 3 groups and cultured in vitro: control (DMEM), cataract (DMEM + 10 microM dexamethasone), aspirin (DMEM + 10 muM dexamethasone + 2 mM aspirin)." | 3.73 | Protective effect of aspirin against dexamethasone-induced cataract in cultured rat lens. ( Liu, B; Shang, L; Wang, J; Yan, H, 2006) |
| "The role of acetylation in the antiglycating and anticataract effects of aspirin (ASA) is explored by comparing ASA's effects with that of sodium salicylate (SS), a nonacetyl analog of ASA, on cataract development in diabetic rats." | 3.70 | Effect of aspirin and sodium salicylate on cataract development in diabetic rats. ( Kanagasabapathy, AS; Selvakumar, R; Shastri, GV; Thomas, K; Thomas, M; Victoria, AJ, 1998) |
| "Effect of twice daily administration of aspirin eyedrops on the onset and progression of cataract induced by 30% galactose diet was studied." | 3.69 | Topical aspirin provides protection against galactosemic cataract. ( Gupta, SK; Joshi, S; Mathur, P; Tandon, R, 1997) |
| " To assess the accuracy of self-reports of cataract, we compared the self-reports with medical record data obtained from diagnosing ophthalmologists and optometrists for participants in the Physicians' Health Study, a randomized trial of aspirin and beta-carotene among 22,071 male U." | 3.69 | Confirmation of self-reported cataract in the Physicians' Health Study. ( Buring, JE; Christen, WG; Glynn, RJ; Hennekens, CH; Manson, JE; Seddon, JM, 1994) |
| "Evidence from epidemiological, in vitro and animal studies has accumulated to support the idea that aspirin, ibuprofen and paracetamol protect against cataract." | 3.68 | Prevention of cataract in diabetic rats by aspirin, paracetamol (acetaminophen) and ibuprofen. ( Blakytny, R; Harding, JJ, 1992) |
| "We examined the association between aspirin use and the rates of cataract extraction during 8 years of follow-up in a large prospective study of women, the Nurses' Health Study." | 3.68 | A prospective study of aspirin use and cataract extraction in women. ( Colditz, GA; Hankinson, SE; Rosner, B; Seddon, JM; Speizer, FE; Stampfer, MJ; Willett, WC, 1993) |
| "To assess the effect of aspirin on cataractogenesis, we compared the stability of individual, native protein fractions alpha L, beta H, beta L, beta s, beta B2, gamma-II, gamma-III and gamma-IV with that of their acetylated counterparts." | 3.68 | Effect of acetylation by aspirin on the thermodynamic stability of lens crystallins. ( Chakrabarti, B; Sen, AC, 1990) |
| " The concentration of TBA-active products decreased in the presence of carnosine and anticataract drugs (Japanese Catalin, Chinese Baineiting and Finnish Catachrom-OFTAN)." | 3.68 | The antioxidative properties of carnosine and other drugs. ( Boldyrev, AA; Chasovnikova, LV; Formazyuk, VE; Sergienko, VI; Severin, SE, 1990) |
| "To evaluate the associations between the use of aspirin and the incidences of cardiovascular diseases, cancers, and other chronic diseases." | 3.67 | Aspirin use and chronic diseases: a cohort study of the elderly. ( Chao, A; Henderson, BE; Paganini-Hill, A; Ross, RK, 1989) |
| "Results of a case-control of 423 cataract patients and 608 controls in Oxfordshire shows that the protective effect against cataract associated with consumption of aspirin-like analgesics (aspirin, paracetamol and ibuprofen family) is manifest even at low doses." | 3.67 | Protection against cataract by aspirin, paracetamol and ibuprofen. ( Egerton, M; Harding, JJ; Harding, RS, 1989) |
| " Myopia and the use of nifedipine were found to carry a significant risk of cataract, and renal failure appeared to carry a high risk, though few patients were affected." | 3.67 | Do aspirin-like analgesics protect against cataract? A case-control study. ( Harding, JJ; van Heyningen, R, 1986) |
| "A population-based cross-sectional survey of 838 men aged 30 years and over was conducted to examine the effect of aspirin, and other potential risk factors, on the prevalence of cataracts." | 3.67 | Lack of evidence for aspirin use and prevention of cataracts. ( Emmett, EA; Muñoz, BE; Newland, HS; Taylor, HR; West, SK, 1987) |
| "The prevalence of cataracts is significantly lower in patients with rheumatoid arthritis receiving aspirin (mean of 2,700 mgs daily for an average of 10." | 3.66 | Aspirin effect on cataract formation in patients with rheumatoid arthritis alone or combined with diabetes. ( Cotlier, E, 1981) |
| "Retrospective studies on cataract development in patients with rheumatoid arthritis or osteoarthritis revealed a retardant effect of aspirin on diabetic and non-diabetic cataracts." | 3.66 | Distribution of salicylate in lens and intraocular fluids and its effect on cataract formation. ( Brescia, M; Cotlier, E; Niven, T; Sharma, YR, 1983) |
| "Cataract is one such disease and post-translational modifications of proteins in the lens during cataract formation are described as a possible guide to the changes in other age-related conditions." | 2.41 | Viewing molecular mechanisms of ageing through a lens. ( Harding, JJ, 2002) |
| "Cataract is the major cause of blindness and of visual impairment worldwide, so its prevention is of the greatest importance." | 2.41 | Can drugs or micronutrients prevent cataract? ( Harding, JJ, 2001) |
| "We encountered an adolescent with Cogan syndrome complicated by aortitis and anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis." | 1.40 | Childhood Cogan syndrome with aortitis and anti-neutrophil cytoplasmic antibody-associated glomerulonephritis. ( Enya, T; Izu, A; Miyazawa, T; Nishi, H; Okada, M; Sugimoto, K; Takemura, T, 2014) |
| "The 4-year incidence of cortical lens opacities was 22." | 1.32 | Risk factors for incident cortical and posterior subcapsular lens opacities in the Barbados Eye Studies. ( Hennis, A; Leske, MC; Nemesure, B; Wu, SY, 2004) |
| "Proliferative vitreoretinopathy is a severe reactive process which leads to the formation of cellular membranes on the surface of the retina and in the vitreous." | 1.29 | Fibroblast growth-promoting activity in proliferative vitreoretinopathy: antagonism by acetylsalicylic acid. ( Göttinger, W; Kähler, CM; Kieselbach, GF; Reinisch, N; Troger, J; Wiedermann, CJ, 1994) |
| "Previous studies have shown that these lens opacities are associated with the occurrence of covalent glucocorticoid-lens protein adducts." | 1.27 | Nonenzymatic modification of lens crystallins by prednisolone induces sulfhydryl oxidation and aggregate formation: in vitro and in vivo studies. ( Bucala, R; Cerami, A; Manabe, S; Urban, RC, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (36.00) | 18.7374 |
| 1990's | 31 (41.33) | 18.2507 |
| 2000's | 12 (16.00) | 29.6817 |
| 2010's | 4 (5.33) | 24.3611 |
| 2020's | 1 (1.33) | 2.80 |
| Authors | Studies |
|---|---|
| Bisht, A | 1 |
| Sharma, M | 1 |
| Sharma, S | 1 |
| Ali, ME | 1 |
| Panda, JJ | 1 |
| Li, Q | 1 |
| Shen, X | 1 |
| Wang, S | 1 |
| Su, T | 1 |
| Yan, K | 1 |
| Zhang, Y | 1 |
| Qian, Y | 1 |
| Jiang, J | 1 |
| Zhang, P | 1 |
| Wang, Z | 1 |
| Dogan, C | 1 |
| Yetik, H | 1 |
| Arslan, OS | 1 |
| Seymen, HO | 1 |
| Suzer, O | 1 |
| Aydin, O | 1 |
| Mergen, B | 1 |
| Sugimoto, K | 1 |
| Miyazawa, T | 1 |
| Nishi, H | 1 |
| Izu, A | 1 |
| Enya, T | 1 |
| Okada, M | 1 |
| Takemura, T | 1 |
| Javadi, S | 1 |
| Yousefi, R | 1 |
| Hosseinkhani, S | 1 |
| Tamaddon, AM | 1 |
| Uversky, VN | 1 |
| Yan, H | 3 |
| Guo, Y | 1 |
| Zhang, J | 1 |
| Ding, Z | 1 |
| Ha, W | 1 |
| Harding, JJ | 14 |
| Shi, Q | 1 |
| Li, MY | 1 |
| Christen, WG | 9 |
| Manson, JE | 8 |
| Glynn, RJ | 7 |
| Gaziano, JM | 1 |
| Sperduto, RD | 5 |
| Buring, JE | 6 |
| Hennekens, CH | 9 |
| Chew, EY | 3 |
| Ferris, FL | 5 |
| Csaky, KG | 1 |
| Murphy, RP | 1 |
| Agrón, E | 1 |
| Thompson, DJ | 1 |
| Reed, GF | 1 |
| Schachat, AP | 1 |
| Hennis, A | 1 |
| Wu, SY | 1 |
| Nemesure, B | 1 |
| Leske, MC | 1 |
| Wang, J | 1 |
| Liu, B | 1 |
| Shang, L | 1 |
| Varma, SD | 1 |
| Hegde, KR | 1 |
| Cotlier, E | 7 |
| Sharma, YR | 3 |
| Slezak, H | 1 |
| Gupta, PP | 1 |
| Pandey, DN | 1 |
| Pandey, DJ | 1 |
| Sharma, AL | 1 |
| Srivastava, RK | 1 |
| Mishra, SS | 1 |
| Niven, T | 1 |
| Brescia, M | 1 |
| González, ER | 1 |
| Seigel, D | 1 |
| Siegel, D | 1 |
| Mathur, SK | 1 |
| Satsangi, UK | 1 |
| Jain, GC | 1 |
| Bernheimer, J | 1 |
| Kähler, CM | 1 |
| Kieselbach, GF | 1 |
| Reinisch, N | 1 |
| Troger, J | 1 |
| Göttinger, W | 1 |
| Wiedermann, CJ | 1 |
| Jones, RH | 1 |
| Hothersall, JS | 1 |
| Hankinson, SE | 1 |
| Seddon, JM | 4 |
| Colditz, GA | 1 |
| Stampfer, MJ | 1 |
| Rosner, B | 2 |
| Speizer, FE | 1 |
| Willett, WC | 1 |
| Qin, W | 1 |
| Smith, JB | 1 |
| Smith, DL | 1 |
| Stevens, A | 1 |
| Heath, MM | 1 |
| Rixon, KC | 2 |
| Dickerson, JE | 1 |
| Dotzel, E | 1 |
| Clark, AF | 1 |
| Gupta, SK | 2 |
| Joshi, S | 2 |
| Tandon, R | 1 |
| Mathur, P | 1 |
| Shastri, GV | 1 |
| Thomas, M | 1 |
| Victoria, AJ | 1 |
| Selvakumar, R | 1 |
| Kanagasabapathy, AS | 1 |
| Thomas, K | 1 |
| Ajani, UA | 3 |
| Schaumberg, DA | 3 |
| Benson, WE | 1 |
| Remaley, NA | 2 |
| Lindley, AA | 1 |
| Burton, TC | 2 |
| Csaky, K | 1 |
| Williams, GA | 2 |
| Yablonski, ME | 1 |
| Cheng, H | 1 |
| Barton, FB | 1 |
| Blakytny, R | 1 |
| Sen, AC | 1 |
| Chakrabarti, B | 1 |
| Woollard, AC | 1 |
| Wolff, SP | 1 |
| Bascal, ZA | 1 |
| Chasovnikova, LV | 1 |
| Formazyuk, VE | 1 |
| Sergienko, VI | 1 |
| Boldyrev, AA | 1 |
| Severin, SE | 1 |
| Paganini-Hill, A | 1 |
| Chao, A | 1 |
| Ross, RK | 1 |
| Henderson, BE | 1 |
| Swamy, MS | 2 |
| Abraham, EC | 2 |
| Egerton, M | 1 |
| Harding, RS | 1 |
| Perry, RE | 1 |
| van Heyningen, R | 2 |
| Kewitz, H | 1 |
| Nitz, M | 1 |
| Gaus, V | 1 |
| Eccarius, S | 1 |
| Clark, JI | 1 |
| West, SK | 1 |
| Muñoz, BE | 1 |
| Newland, HS | 1 |
| Emmett, EA | 1 |
| Taylor, HR | 1 |
| Crompton, M | 1 |
| Rao, GN | 1 |
| Lardis, MP | 1 |
| Bucala, R | 1 |
| Manabe, S | 1 |
| Urban, RC | 1 |
| Cerami, A | 1 |
| Costello, JM | 1 |
| Shannon, FT | 1 |
| Westring, DW | 1 |
| Pisciotta, AV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00000157] | Phase 3 | 0 participants | Interventional | 1982-04-30 | Terminated | ||
| [NCT00000500] | Phase 3 | 0 participants | Interventional | 1981-09-30 | Completed | ||
| A Randomized Clinical Trial of Intravitreal dexamethasOne Versus Bevacizumab in Aboriginal and Torres Strait Islander patientS With Diabetic Macular Oedema (The OASIS Study)[NCT04619303] | Phase 4 | 59 participants (Actual) | Interventional | 2017-02-07 | Completed | ||
| [NCT00000151] | Phase 3 | 0 participants | Interventional | 1979-12-31 | Completed | ||
| Acetylsalicylic Acid Administered in Patients With Type 2 Diabetes Mellitus and Its Effect on the Antioxidant Enzyme System[NCT03341117] | Phase 3 | 21 participants (Actual) | Interventional | 2014-12-02 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for aspirin and Cataract
| Article | Year |
|---|---|
Can drugs or micronutrients prevent cataract?
Topics: Aldehyde Reductase; Aspirin; Cataract; Clinical Trials as Topic; Drug Design; Estrogens; Glutathione | 2001 |
Viewing molecular mechanisms of ageing through a lens.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cataract; Cellular Senescence; Cry | 2002 |
11 trials available for aspirin and Cataract
| Article | Year |
|---|---|
A randomized trial of beta carotene and age-related cataract in US physicians.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspiri | 2003 |
The long-term effects of laser photocoagulation treatment in patients with diabetic retinopathy: the early treatment diabetic retinopathy follow-up study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cataract; Diabetic Retinopathy; Femal | 2003 |
Study to begin on whether aspirin can delay senile cataract formation.
Topics: Aged; Aspirin; Cataract; Clinical Trials as Topic; Diabetes Mellitus; Dose-Response Relationship, Dr | 1980 |
Body mass index. An independent predictor of cataract.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; beta Carotene; Body Constitution; Body Mass Index; Cardiova | 1995 |
Low-dose aspirin and risk of cataract and subtypes in a randomized trial of U.S. physicians.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cataract; Cataract | 1998 |
Results after lens extraction in patients with diabetic retinopathy: early treatment diabetic retinopathy study report number 25.
Topics: Aspirin; Cataract; Cataract Extraction; Diabetic Retinopathy; Disease Progression; Female; Humans; L | 1999 |
Baseline self-reported cataract and subsequent mortality in Physicians' Health Study I.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspirin; Cardiovascular Diseases; Cataract; Cause of Death; H | 2000 |
Aspirin use and risk of cataract in posttrial follow-up of Physicians' Health Study I.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cataract; Cataract | 2001 |
Does aspirin affect the rate of cataract formation? Cross-sectional results during a randomised double-blind placebo controlled trial to prevent serious vascular events. UK-TIA Study Group.
Topics: Aspirin; Cataract; Cross-Sectional Studies; Double-Blind Method; Humans; Prevalence; United Kingdom | 1992 |
Aspirin effects on the development of cataracts in patients with diabetes mellitus. Early treatment diabetic retinopathy study report 16.
Topics: Adult; Aspirin; Cataract; Diabetes Complications; Diabetic Retinopathy; Female; Follow-Up Studies; H | 1992 |
Low-dose aspirin and risks of cataract in a randomized trial of US physicians.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cataract; Cataract Extraction; Cohort Studies; Dose-Respons | 1991 |
Low-dose aspirin and risks of cataract in a randomized trial of US physicians.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cataract; Cataract Extraction; Cohort Studies; Dose-Respons | 1991 |
Low-dose aspirin and risks of cataract in a randomized trial of US physicians.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cataract; Cataract Extraction; Cohort Studies; Dose-Respons | 1991 |
Low-dose aspirin and risks of cataract in a randomized trial of US physicians.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cataract; Cataract Extraction; Cohort Studies; Dose-Respons | 1991 |
62 other studies available for aspirin and Cataract
| Article | Year |
|---|---|
Carrier-free self-built aspirin nanorods as anti-aggregation agents towards alpha-crystallin-derived peptide aggregates: potential implications in non-invasive cataract therapy.
Topics: alpha-Crystallins; Animals; Aspirin; Cataract; Computer Simulation; Models, Molecular; Nanotubes; Pe | 2019 |
Combined aspirin and clopidogrel therapy in phacoemulsification cataract surgery: a risk factor for ocular hemorrhage?
Topics: Aspirin; Cataract; Clopidogrel; Humans; Lens Implantation, Intraocular; Phacoemulsification; Postope | 2020 |
The safety of intraocular usage of aspirin.
Topics: Animals; Aspirin; Cataract; Cyclooxygenase Inhibitors; Electroretinography; Eye; Female; Intravitrea | 2019 |
Childhood Cogan syndrome with aortitis and anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.
Topics: Adolescent; Adult; Antibodies, Antineutrophil Cytoplasmic; Antirheumatic Agents; Aortitis; Aspirin; | 2014 |
Protective effects of carnosine on dehydroascorbate-induced structural alteration and opacity of lens crystallins: important implications of carnosine pleiotropic functions to combat cataractogenesis.
Topics: alpha-Crystallins; Animals; Aspirin; Carnosine; Cataract; Cattle; Dehydroascorbic Acid; Electrophore | 2017 |
Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats.
Topics: Animals; Aspirin; Blood Glucose; Body Weight; Carnosine; Cataract; Cornea; Diabetes Mellitus, Experi | 2008 |
Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats.
Topics: Animals; Aspirin; Blood Glucose; Body Weight; Carnosine; Cataract; Diabetes Complications; Drinking | 2009 |
Risk factors for incident cortical and posterior subcapsular lens opacities in the Barbados Eye Studies.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Barbados; Black People; Cataract; Cohort Studies; Diabetes | 2004 |
Protective effect of aspirin against dexamethasone-induced cataract in cultured rat lens.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Catalase; Cataract; Dexamethasone; L-Lact | 2006 |
Susceptibility of the ocular lens to nitric oxide: implications in cataractogenesis.
Topics: Adenosine Triphosphate; Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biological | 2007 |
Plasma tryptophan in senile cataract.
Topics: Aged; Aspirin; Cataract; Humans; Tryptophan | 1980 |
Aspirin and senile cataracts in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Aspirin; Cataract; Humans; Lens, Crystalline; Middle Aged | 1981 |
[Drug-induced eye lesions in the aged].
Topics: Aged; Antipsychotic Agents; Aspirin; Cataract; Conjunctival Diseases; Corneal Diseases; Eye Diseases | 1983 |
Aspirin in experimental cataractogenesis.
Topics: Animals; Aspirin; Cataract; Disease Models, Animal; Female; Galactose; Male; Naphthalenes; Rabbits; | 1984 |
Distribution of salicylate in lens and intraocular fluids and its effect on cataract formation.
Topics: Animals; Aqueous Humor; Aspirin; Cataract; Crystallins; Diabetes Complications; Galactose; Humans; L | 1983 |
Aspirin and cataracts.
Topics: Aged; Arthritis, Rheumatoid; Aspirin; Cataract; Female; Humans; Male; Middle Aged; Osteoarthritis; R | 1982 |
Is ASA therapy for cataracts justified?
Topics: Aspirin; Cataract; Humans; Research Design | 1982 |
Aspirin effect on cataract formation in patients with rheumatoid arthritis alone or combined with diabetes.
Topics: Aged; Arthritis, Rheumatoid; Aspirin; Cataract; Diabetes Complications; Female; Humans; Male; Middle | 1981 |
Senile cataracts: evidence for acceleration by diabetes and deceleration by salicylate.
Topics: Age Factors; Aged; Aspirin; Cataract; Diabetes Complications; Humans; Middle Aged; Osteoarthritis; T | 1981 |
Effect of antiprostaglandin drugs on human blood--aqueous barrier.
Topics: Aged; Aqueous Humor; Aspirin; Cataract; Cataract Extraction; Eye Proteins; Female; Humans; Indometha | 1981 |
Fibroblast growth-promoting activity in proliferative vitreoretinopathy: antagonism by acetylsalicylic acid.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Cataract; Cell Division; Cells, Cultured; | 1994 |
Prevention of cataract.
Topics: Aspirin; Cataract; Humans | 1993 |
Increased susceptibility to metal catalysed oxidation of diabetic lens beta L crystallin: possible protection by dietary supplementation with acetylsalicylic acid.
Topics: Animals; Ascorbic Acid; Aspirin; Cataract; Copper; Crystallins; Diabetes Mellitus, Experimental; Hyd | 1993 |
A prospective study of aspirin use and cataract extraction in women.
Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cataract; Cataract Extraction; | 1993 |
Alzheimer disease (AD), modified proteins, and aspirin.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aspirin; Cataract; Humans; Neurofibrillary Tangles | 1993 |
Reaction of aspirin with cysteinyl residues of lens gamma-crystallins: a mechanism for the proposed anti-cataract effect of aspirin.
Topics: Acetylation; Amino Acid Sequence; Animals; Aspirin; Cataract; Cattle; Crystallins; Cyanates; Cystein | 1993 |
The effectiveness of putative anti-cataract agents in the prevention of protein glycation.
Topics: Animals; Aspirin; Cataract; Cattle; Eye Proteins; Glycation End Products, Advanced; Glycosylation; G | 1995 |
Glycation-induced inactivation of malate dehydrogenase protection by aspirin and a lens molecular chaperone, alpha-crystallin.
Topics: Animals; Aspirin; Carbohydrates; Cataract; Crystallins; Diabetes Complications; Diabetes Mellitus; G | 1996 |
Confirmation of self-reported cataract in the Physicians' Health Study.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Aspirin; beta Carotene; Cardiovascular Diseases; Carot | 1994 |
Steroid-induced cataract: new perspective from in vitro and lens culture studies.
Topics: Aldosterone; Animals; Aspirin; Cataract; Cattle; Cells, Cultured; Cross-Linking Reagents; Crystallin | 1997 |
Topical aspirin provides protection against galactosemic cataract.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cataract; Diet; | 1997 |
Effect of aspirin and sodium salicylate on cataract development in diabetic rats.
Topics: Animals; Aspirin; Cataract; Diabetes Mellitus, Experimental; Disease Progression; Drug Evaluation, P | 1998 |
Aspirin and cataract risk.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cataract; Cataract Extraction; Humans; Middle Aged; Randomi | 1999 |
Consultation section. Cataract surgical problem.
Topics: Aspirin; Cataract; Humans; Hypertension; Male; Middle Aged; Phacoemulsification; Retinal Vein Occlus | 1999 |
Aspirin and cataract.
Topics: Aspirin; Cataract; Humans; Lens, Crystalline; New South Wales | 1999 |
The presence of cataract as a predictor of mortality.
Topics: Aspirin; Biomarkers; Cataract; Humans; Risk Factors | 2001 |
Preventing cataract.
Topics: Aspirin; Cataract; Humans | 1992 |
Aspirin and cataract.
Topics: Aspirin; Cataract; Humans | 1992 |
A prospective study of cigarette smoking and risk of cataract in men.
Topics: Adult; Aged; Aspirin; beta Carotene; Cardiovascular Diseases; Carotenoids; Cataract; Follow-Up Studi | 1992 |
Prevention of cataract in diabetic rats by aspirin, paracetamol (acetaminophen) and ibuprofen.
Topics: Acetaminophen; Animals; Aspirin; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Female; G | 1992 |
Relationship between aldose reductase inhibiting activity and anti-cataract action of various non-steroidal anti-inflammatory drugs.
Topics: Aldehyde Reductase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cataract; Flurbiprofe | 1991 |
Aspirin and cataract.
Topics: Aspirin; Case-Control Studies; Cataract; Coronary Disease; Humans; Male; Patient Compliance; Randomi | 1991 |
Effect of acetylation by aspirin on the thermodynamic stability of lens crystallins.
Topics: Acetylation; Animals; Aspirin; Cataract; Cattle; Circular Dichroism; Crystallins; Hot Temperature; P | 1990 |
Antioxidant characteristics of some potential anticataract agents. Studies of aspirin, paracetamol, and bendazac provide support for an oxidative component of cataract.
Topics: Acetaminophen; Ampyrone; Antioxidants; Aspirin; Biphenyl Compounds; Cataract; Chelating Agents; Eryt | 1990 |
India-US case-control study of age-related cataracts.
Topics: Aging; Aspirin; Case-Control Studies; Cataract; Humans; India; United States | 1990 |
The antioxidative properties of carnosine and other drugs.
Topics: Acridines; alpha-Tocopherol; Animals; Aspirin; Carnosine; Cataract; Dipeptides; Ferrous Compounds; K | 1990 |
Aspirin use and chronic diseases: a cohort study of the elderly.
Topics: Aged; Aged, 80 and over; Aspirin; California; Cataract; Chronic Disease; Cohort Studies; Coronary Di | 1989 |
Inhibition of lens crystallin glycation and high molecular weight aggregate formation by aspirin in vitro and in vivo.
Topics: Animals; Aspirin; Cataract; Crystallins; Diabetes Mellitus, Experimental; Glucose; In Vitro Techniqu | 1989 |
Protection against cataract by aspirin, paracetamol and ibuprofen.
Topics: Acetaminophen; Aged; Aspirin; Cataract; England; Female; Humans; Ibuprofen; Male; Middle Aged; Risk | 1989 |
Nonenzymatic glycosylation (glycation) of lens crystallins in diabetes and aging.
Topics: Acetylation; Aging; Animals; Aspirin; Cataract; Crystallins; Diabetes Mellitus, Experimental; Glycos | 1989 |
Do aspirin-like analgesics protect against cataract? A case-control study.
Topics: Acetaminophen; Aged; Analgesics; Aspirin; Cataract; Diabetes Complications; Epidemiologic Methods; F | 1986 |
Aspirin, nifedipine, and cataract.
Topics: Angina Pectoris; Aspirin; Cataract; Humans; Nifedipine | 1986 |
Aspirin-like analgesics and cataract.
Topics: Analgesics; Aspirin; Cataract; Humans | 1986 |
Aspirin and cataract.
Topics: Analgesics; Aspirin; Cataract; Humans | 1986 |
[New benefits of aspirin].
Topics: Aspirin; Cataract; Humans; Myocardial Infarction; Reye Syndrome | 1988 |
Effect of aspirin and vitamin E on phase separation in calf lens homogenate.
Topics: Animals; Aspirin; Body Temperature; Cataract; Cattle; Lasers; Lens, Crystalline; Ophthalmology; Vita | 1987 |
Lack of evidence for aspirin use and prevention of cataracts.
Topics: Adult; Age Factors; Aspirin; Cataract; Dose-Response Relationship, Drug; Humans; Male; Regression An | 1987 |
Aspirin prevents carbamylation of soluble lens proteins and prevents cyanate-induced phase separation opacities in vitro: a possible mechanism by which aspirin could prevent cataract.
Topics: Animals; Aspirin; Cataract; Cattle; Crystallins; Cyanates; In Vitro Techniques; Lens, Crystalline; P | 1985 |
Acetylation of lens crystallins: a possible mechanism by which aspirin could prevent cataract formation.
Topics: Acetylation; Animals; Aspirin; Binding Sites; Cataract; Cattle; Chemical Phenomena; Chemistry; Cryst | 1985 |
Nonenzymatic modification of lens crystallins by prednisolone induces sulfhydryl oxidation and aggregate formation: in vitro and in vivo studies.
Topics: Acetylation; Aspirin; Cataract; Chromatography, Gel; Crystallins; Dithiothreitol; Humans; In Vitro T | 1985 |
Drugs and children.
Topics: Aminophylline; Aspirin; Atropine; Cardiomyopathies; Cataract; Child, Preschool; Chloramphenicol; Chl | 1968 |
Anemia, cataracts, and seizures in patient with glucose-6-phosphate dehydrogenase deficiency.
Topics: Anemia, Hemolytic, Congenital Nonspherocytic; Aspirin; Cataract; Chromium Isotopes; Electrophoresis; | 1966 |