Page last updated: 2024-10-23

aspirin and Carotid Artery Narrowing

aspirin has been researched along with Carotid Artery Narrowing in 219 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"To analyze the association between low-dose rivaroxaban with or without aspirin and different ischemic stroke subtypes."9.34Association Between Low-Dose Rivaroxaban With or Without Aspirin and Ischemic Stroke Subtypes: A Secondary Analysis of the COMPASS Trial. ( Bosch, J; Catanese, L; Connolly, SJ; Dyal, L; Eikelboom, JW; Hart, RG; Nayar, S; Ng, KKH; Perera, KS; Sharma, M; Yusuf, S, 2020)
"Ticagrelor is an effective antiplatelet therapy among patients with atherosclerotic disease and, therefore, could be more effective than aspirin in preventing recurrent stroke and cardiovascular events among patients with embolic stroke of unknown source (ESUS), which includes patients with ipsilateral stenosis <50% and aortic arch atherosclerosis."9.24Ticagrelor Versus Aspirin in Acute Embolic Stroke of Undetermined Source. ( Albers, GW; Amarenco, P; Denison, H; Easton, JD; Evans, SR; Held, P; Hill, MD; Johnston, SC; Jonasson, J; Kasner, SE; Ladenvall, P; Minematsu, K; Molina, CA; Wang, Y; Wong, KSL, 2017)
" We investigated the effects of cilostazol 200 mg, in addition to aspirin 100 mg and clopidogrel 75 mg, on carotid intima-media thickness (IMT) progression during a 2-year follow-up period in patients with acute coronary syndrome (ACS) requiring stent implantation."9.15Cilostazol reduces the progression of carotid intima-media thickness without increasing the risk of bleeding in patients with acute coronary syndrome during a 2-year follow-up. ( Ahn, CM; Hong, SJ; Kim, JS; Lim, DS; Park, JH, 2011)
"PERFORM is exploring the efficacy of terutroban versus aspirin for secondary prevention in patients with a history of ischemic stroke or transient ischemic attacks (TIAs)."9.14Rationale, design and population baseline characteristics of the PERFORM vascular project: an ancillary study of the Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history oF ischemic strOke o ( Bots, ML; Ford, I; Hennerici, MG; Laurent, S; Touboul, PJ, 2010)
"Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) is a randomized, double-blind study in subjects with recently symptomatic > or =50% carotid stenosis."9.11Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial. ( Droste, DW; Kaps, M; Larrue, V; Lees, KR; Markus, HS; Ringelstein, EB; Siebler, M, 2005)
"Mortality rates in this group were not significantly different for patients not taking aspirin as compared with the rates for those taking aspirin, although patients not taking aspirin had a higher incidence of myocardial infarction (27%) as compared with patients taking aspirin (8%), p < 0."9.07Influence of aspirin in the management of asymptomatic carotid artery stenosis. VA Cooperative Study Group on Asymptomatic Carotid Stenosis. ( Hobson, RW; Krupski, WC; Weiss, DG, 1993)
"Clopidogrel is commonly used for secondary stroke prevention in patients with large vessel stenosis."8.02Clopidogrel underactivity is a common in patients with acute symptomatic severe carotid stenosis. ( Cohen, JE; Filioglo, A; Gomori, JM; Honig, A; Horev, A; Kalish, Y; Leker, RR; Sacagiu, T; Simaan, N, 2021)
" Diabetes mellitus and current smoker status were independent factors related to reactivity to clopidogrel."7.83Influence of Diabetes Mellitus and Cigarette Smoking on Variability of the Clopidogrel-Induced Antiplatelet Effect and Efficacy of Active Management of the Target P2Y12 Reaction Unit Range in Patients Undergoing Neurointerventional Procedures. ( Hironaka, Y; Kichikawa, K; Motoyama, Y; Nakagawa, I; Nakase, H; Park, HS; Takayama, K; Wada, T; Yokoyama, S, 2016)
"Although different populations were examined for the incidence of aspirin resistance, the frequency and related risk factors for aspirin resistance in patients with metabolic syndrome have not been reported yet."7.74The frequency of aspirin resistance and its risk factors in patients with metabolic syndrome. ( Agacdiken, A; Baytugan, NZ; Kahraman, G; Kilic, T; Komsuoglu, B; Sahin, T; Ural, D; Ural, E, 2007)
"The CARESS (Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic carotid Stenosis) trial proved the effectiveness of the combination of clopidogrel and aspirin compared with aspirin alone in reducing presence and number of microembolic signals (MES) in patients with recently symptomatic carotid stenosis."7.73The use of embolic signal detection in multicenter trials to evaluate antiplatelet efficacy: signal analysis and quality control mechanisms in the CARESS (Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic carotid Stenosis) trial. ( Dittrich, R; Droste, DW; Kaps, M; Larrue, V; Lees, K; Markus, HS; Nabavi, DG; Ringelstein, EB; Ritter, MA; Siebler, M, 2006)
"We recruited 131 patients with minor ischaemic stroke, within less than 7 days of stroke onset and a CYP2C19 loss-of-function allele, who had moderate-to-severe cerebral artery stenosis."6.94Effectiveness and safety of high dose clopidogrel plus aspirin in ischemic stroke patients with the single CYP2C19 loss-of-function allele: a randomized trial. ( Chen, Q; Chu, W; Dong, M; Dou, L; Gao, B; Li, B; Li, J; Liu, C; Pan, Y; Song, H; Song, L; Wu, H, 2020)
" We sought to determine whether the presence of carotid stenosis was associated with increased risk of ischemic stroke and whether the addition of clopidogrel to aspirin was associated with more benefit in patients with versus without carotid stenosis."5.41Carotid Stenosis and Recurrent Ischemic Stroke: A Post-Hoc Analysis of the POINT Trial. ( de Havenon, A; Easton, JD; Furie, KL; Henninger, N; Johnston, SC; Kim, AS; Kvernland, A; Mac Grory, B; Rostanski, S; Yaghi, S, 2021)
"Aspirin resistance was more common in patients with MES (50% compared to 17."5.38Microembolic signals and aspirin resistance in patients with carotid stenosis. ( Dawson, J; Lees, KR; Quinn, T; Walters, MR, 2012)
"To analyze the association between low-dose rivaroxaban with or without aspirin and different ischemic stroke subtypes."5.34Association Between Low-Dose Rivaroxaban With or Without Aspirin and Ischemic Stroke Subtypes: A Secondary Analysis of the COMPASS Trial. ( Bosch, J; Catanese, L; Connolly, SJ; Dyal, L; Eikelboom, JW; Hart, RG; Nayar, S; Ng, KKH; Perera, KS; Sharma, M; Yusuf, S, 2020)
"Ticagrelor is an effective antiplatelet therapy among patients with atherosclerotic disease and, therefore, could be more effective than aspirin in preventing recurrent stroke and cardiovascular events among patients with embolic stroke of unknown source (ESUS), which includes patients with ipsilateral stenosis <50% and aortic arch atherosclerosis."5.24Ticagrelor Versus Aspirin in Acute Embolic Stroke of Undetermined Source. ( Albers, GW; Amarenco, P; Denison, H; Easton, JD; Evans, SR; Held, P; Hill, MD; Johnston, SC; Jonasson, J; Kasner, SE; Ladenvall, P; Minematsu, K; Molina, CA; Wang, Y; Wong, KSL, 2017)
" In a previous study, we found that the number of MESs is associated with stroke recurrence and that clopidogrel plus aspirin more effectively reduce the number of MESs than does aspirin alone."5.22The curative effect comparison of two kinds of therapeutic regimens on decreasing the relative intensity of microembolic signal in CLAIR trial. ( Chen, C; Deng, QQ; Fu, JH; Huang, YN; Markus, H; Ratanakorn, D; Tang, J; Wong, KS; Zhao, H, 2016)
"Carotid endarterectomy and medical therapy (aspirin) were shown superior to medical therapy alone for asymptomatic (≥ 60%) carotid stenosis."5.20Optimal medical treatment versus carotid endarterectomy: the rationale and design of the Aggressive Medical Treatment Evaluation for Asymptomatic Carotid Artery Stenosis (AMTEC) study. ( Boytsov, S; Deev, A; Dupik, N; Kolos, I; Loukianov, M, 2015)
" Patients with Helicobacter pylori infection and a history of peptic ulcer were assigned dual antiplatelet combination with omeprazole."5.17Effect of clopidogrel with or without omeprazole in patients with carotid artery stenting. ( Chen, G; Du, Y; Hang, L; Ma, B, 2013)
" We investigated the effects of cilostazol 200 mg, in addition to aspirin 100 mg and clopidogrel 75 mg, on carotid intima-media thickness (IMT) progression during a 2-year follow-up period in patients with acute coronary syndrome (ACS) requiring stent implantation."5.15Cilostazol reduces the progression of carotid intima-media thickness without increasing the risk of bleeding in patients with acute coronary syndrome during a 2-year follow-up. ( Ahn, CM; Hong, SJ; Kim, JS; Lim, DS; Park, JH, 2011)
"PERFORM is exploring the efficacy of terutroban versus aspirin for secondary prevention in patients with a history of ischemic stroke or transient ischemic attacks (TIAs)."5.14Rationale, design and population baseline characteristics of the PERFORM vascular project: an ancillary study of the Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history oF ischemic strOke o ( Bots, ML; Ford, I; Hennerici, MG; Laurent, S; Touboul, PJ, 2010)
"The clopidogrel plus aspirin for infarction reduction in acute stroke or transient ischaemic attack patients with large artery stenosis and microembolic signals (CLAIR) trial was a randomised, open-label, blinded-endpoint trial."5.14Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial. ( Chang, HM; Chen, C; Chollate, P; Fu, J; Han, Z; Hao, Q; Huang, YN; Koh, A; Markus, HS; Ratanakorn, D; Suwanwela, NC; Tan, KS; Wong, KS; Zhao, Y, 2010)
"Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) is a randomized, double-blind study in subjects with recently symptomatic > or =50% carotid stenosis."5.11Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial. ( Droste, DW; Kaps, M; Larrue, V; Lees, KR; Markus, HS; Ringelstein, EB; Siebler, M, 2005)
"To determine the effectiveness of aspirin in preventing ischemic events in patients with asymptomatic carotid stenosis."5.08Lack of effect of aspirin in asymptomatic patients with carotid bruits and substantial carotid narrowing. The Asymptomatic Cervical Bruit Study Group. ( Abrahamowicz, M; Battista, RN; Bourque, F; Côté, R; Langlois, Y; Mackey, A, 1995)
"Mortality rates in this group were not significantly different for patients not taking aspirin as compared with the rates for those taking aspirin, although patients not taking aspirin had a higher incidence of myocardial infarction (27%) as compared with patients taking aspirin (8%), p < 0."5.07Influence of aspirin in the management of asymptomatic carotid artery stenosis. VA Cooperative Study Group on Asymptomatic Carotid Stenosis. ( Hobson, RW; Krupski, WC; Weiss, DG, 1993)
"We undertook a randomized controlled trial designed to compare the effects of carotid endarterectomy with medical treatment using low-dose aspirin in patients with asymptomatic carotid stenosis."5.07Results of a randomized controlled trial of carotid endarterectomy for asymptomatic carotid stenosis. Mayo Asymptomatic Carotid Endarterectomy Study Group. ( , 1992)
" Data from one randomised controlled trial showed no significant difference in benefit with aspirin versus placebo in asymptomatic carotid stenosis, but it is still reasonable to recommend aspirin (81-325 mg daily) for prevention of vascular events in these patients."5.01Optimal Antiplatelet Therapy in Moderate to Severe Asymptomatic and Symptomatic Carotid Stenosis: A Comprehensive Review of the Literature. ( de Borst, GJ; Halliday, A; Hamilton, G; Kakkos, S; McCabe, DJH; Murphy, SJX; Naylor, AR; Ricco, JB; Sillesen, H; Vega de Ceniga, M, 2019)
"Drugs that prevent platelets from sticking together-ie, aspirin, dipyridamole, and clopidogrel-are an important part of therapy to prevent recurrence of ischemic stroke of atherosclerotic origin."4.89Antiplatelet therapy to prevent recurrent stroke: Three good options. ( Mansoor, AH; Mujtaba, MT; Silver, B, 2013)
" Currently, aspirin is generally prescribed for the primary prevention of stroke despite a number of trial results on effectiveness proving inconclusive."4.85Antithrombotic therapies in cerebrovascular disease: what should we use as secondary prevention in patients with carotid artery disease? ( Beckman, JA, 2009)
" Increased leptin, dysregulation of adipocyte proteins, increased insulin resistance and C-reactive protein may be factors involved in the increased incidence of cardiovascular morbidity and mortality directly related to obesity."4.83Stroke prevention in diabetes and obesity. ( Govindarajan, G; Kurukulasuriya, LR; Sowers, J, 2006)
" (1) Proven: one or more TIAs in the past 6 months and carotid stenosis > or = 70% or mild stroke within 6 months and a carotid stenosis > or = 70%; (2) acceptable but not proven: TIAs within the past 6 months and a stenosis 50% to 69%, progressive stroke and a stenosis > or = 70%, mild or moderate stroke in the past 6 months and a stenosis 50% to 69%, or carotid endarterectomy ipsilateral to TIAs and a stenosis > or = 70% combined with required coronary artery bypass grafting; (3) uncertain: TIAs with a stenosis < 50%, mild stroke and stenosis < 50%, TIAs with a stenosis < 70% combined with coronary artery bypass grafting, or symptomatic, acute carotid thrombosis; (4) proven inappropriate: moderate stroke with stenosis < 50%, not on aspirin; single TIA, < 50% stenosis, not on aspirin; high-risk patient with multiple TIAs, not on aspirin, stenosis < 50%; high-risk patient, mild or moderate stroke, stenosis < 50%, not on aspirin; global ischemic symptoms with stenosis < 50%; acute dissection, asymptomatic on heparin."4.79Guidelines for carotid endarterectomy. A multidisciplinary consensus statement from the ad hoc Committee, American Heart Association. ( Barnett, HJ; Beebe, HG; Bernstein, EF; Brener, BJ; Brott, T; Caplan, LR; Day, A; Goldstone, J; Hobson, RW; Moore, WS, 1995)
" We aim to compare rates of postoperative bleeding, stroke and major adverse events (stroke, death or MI) among patients on Aspirin alone (ASAA) versus DAPT (Clopidogrel and Aspirin)."4.31Dual Antiplatelet Therapy Is Associated with Increased Risk of Bleeding and Decreased Risk of Stroke Following Carotid Endarterectomy. ( Dakour, H; Elsayed, N; Malas, MB; Marmor, R; Patel, RJ; Ramachandran, M, 2023)
"Compared with aspirin/clopidogrel, aspirin/ticagrelor was associated with a potentially lower risk of stroke/death and bleeding complications after CAS in cases in which protamine was used but a higher risk of these outcomes in the absence of protamine."4.12Efficacy and safety of perioperative dual antiplatelet therapy with ticagrelor versus clopidogrel in carotid artery stenting. ( Jim, J; Liang, P; Marcaccio, CL; Patel, PB; Rastogi, V; Schermerhorn, ML; Schneider, PA; Stangenberg, L, 2022)
"Clopidogrel is commonly used for secondary stroke prevention in patients with large vessel stenosis."4.02Clopidogrel underactivity is a common in patients with acute symptomatic severe carotid stenosis. ( Cohen, JE; Filioglo, A; Gomori, JM; Honig, A; Horev, A; Kalish, Y; Leker, RR; Sacagiu, T; Simaan, N, 2021)
"A total of 176 patients taking antiplatelet medications aspirin and/or clopidogrel with peripheral artery disease (PAD) and/or carotid stenosis (CS) were included in the study."3.96Perioperative changes of response to antiplatelet medication in vascular surgery patients. ( Breuer-Kaiser, A; Düsterwald, JO; Hummel, T; Meves, SH; Mühlberger, D; Mumme, A; Neubauer, H, 2020)
"A retrospective, single center, cohort study was carried out of 32 patients who underwent eCAS (18 received tirofiban, 14 received aspirin) at our comprehensive stroke center (2008-2016)."3.91Acute administration of tirofiban versus aspirin in emergent carotid artery stenting. ( Berberat, J; Diepers, M; Gruber, P; Hlavica, M; Kahles, T; Nedeltchev, K; Remonda, L; Victor Ineichen, B, 2019)
" Diabetes mellitus and current smoker status were independent factors related to reactivity to clopidogrel."3.83Influence of Diabetes Mellitus and Cigarette Smoking on Variability of the Clopidogrel-Induced Antiplatelet Effect and Efficacy of Active Management of the Target P2Y12 Reaction Unit Range in Patients Undergoing Neurointerventional Procedures. ( Hironaka, Y; Kichikawa, K; Motoyama, Y; Nakagawa, I; Nakase, H; Park, HS; Takayama, K; Wada, T; Yokoyama, S, 2016)
"Data obtained in this study suggest a suboptimal clopidogrel response in patients with greater body weight and body mass index."3.77Body weight: a risk factor for subtherapeutic antithrombotic therapy in neurovascular stenting. ( Alexander, MJ; Choulakian, A; Drazin, D; Kornbluth, P; Nuño, M, 2011)
"Although different populations were examined for the incidence of aspirin resistance, the frequency and related risk factors for aspirin resistance in patients with metabolic syndrome have not been reported yet."3.74The frequency of aspirin resistance and its risk factors in patients with metabolic syndrome. ( Agacdiken, A; Baytugan, NZ; Kahraman, G; Kilic, T; Komsuoglu, B; Sahin, T; Ural, D; Ural, E, 2007)
"The CARESS (Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic carotid Stenosis) trial proved the effectiveness of the combination of clopidogrel and aspirin compared with aspirin alone in reducing presence and number of microembolic signals (MES) in patients with recently symptomatic carotid stenosis."3.73The use of embolic signal detection in multicenter trials to evaluate antiplatelet efficacy: signal analysis and quality control mechanisms in the CARESS (Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic carotid Stenosis) trial. ( Dittrich, R; Droste, DW; Kaps, M; Larrue, V; Lees, K; Markus, HS; Nabavi, DG; Ringelstein, EB; Ritter, MA; Siebler, M, 2006)
"(1) Aspirin reduces the risk of myocardial infarction in men over 40 with no history of cardiovascular disease, and in hypertensive patients of both sexes over that age."3.70Antiplatelet drugs in cardiovascular prevention: coronary events and stroke: primary prevention. ( , 2000)
" In addition, the antithrombotic effects of SK&F 106760 were compared with those of aspirin in an acute canine model of extracranial carotid artery thrombosis with high-grade stenosis."3.68Antithrombotic effects of a platelet fibrinogen receptor antagonist in a canine model of carotid artery thrombosis. ( Feuerstein, GZ; Nichols, AJ; Ohlstein, EH; Rycyna, R; Sarkar, S; Sauermelch, CF; Willette, RN, 1992)
"Asymptomatic carotid stenosis is when this narrowing occurs in people without a history or symptoms of this disease."3.01Pharmacological interventions for asymptomatic carotid stenosis. ( Cassola, N; Clezar, CN; Flumignan, CD; Flumignan, RL; Nakano, LC; Trevisani, VF, 2023)
"We recruited 131 patients with minor ischaemic stroke, within less than 7 days of stroke onset and a CYP2C19 loss-of-function allele, who had moderate-to-severe cerebral artery stenosis."2.94Effectiveness and safety of high dose clopidogrel plus aspirin in ischemic stroke patients with the single CYP2C19 loss-of-function allele: a randomized trial. ( Chen, Q; Chu, W; Dong, M; Dou, L; Gao, B; Li, B; Li, J; Liu, C; Pan, Y; Song, H; Song, L; Wu, H, 2020)
"Aspirin-HTPR was noted in 9."2.82Platelet Biomarkers in Patients with Atherosclerotic Extracranial Carotid Artery Stenosis: A Systematic Review. ( de Borst, GJ; Delaney, S; Hamilton, G; Kinsella, JA; McCabe, DJH; McMahon, J; Murphy, SJX; Naylor, AR; Offiah, C; Smith, DR; Subramanian, A, 2022)
"aspirin monotherapy was carried out, to determine optimal peri-operative management with these antiplatelet agents."2.82Editor's Choice - Peri-Operative Outcomes of Carotid Endarterectomy are Not Improved on Dual Antiplatelet Therapy vs. Aspirin Monotherapy: A Systematic Review and Meta-Analysis. ( Bissacco, D; Chechik, O; Chisci, E; Cusimano, MD; Ku, JC; Larrue, V; Macdonald, RL; Michelagnoli, S; Nasr, N; Pasarikovski, CR; Priola, SM; Rabinovich, Y; Settembrini, PG; Taslimi, S; Yang, VXD; Zuccato, J, 2022)
"Strokes are infrequent but potentially serious complications following carotid intervention, but antiplatelet therapy can reduce these risks."2.82Antiplatelet Therapy in Carotid Artery Stenting and Carotid Endarterectomy in the Asymptomatic Carotid Surgery Trial-2. ( Bulbulia, R; Coppi, G; de Borst, GJ; Halliday, A; Huibers, A, 2016)
"To investigate the effect of removing phlegm and dispelling stasis method (RPDSM) combined with Western medicine for treatment of cerebrovascular stenosis."2.73[Removing phlegm and dispelling stasis method combined with Western medicine for treatment of cerebrovascular stenosis]. ( Gao, L; Liu, Q; Wang, PP, 2008)
"In patients with symptomatic carotid artery stenosis, high-intensity transient signals detected by transcranial Doppler (TCD) have been related to particulate microemboli originating at the stenotic lesion."2.70Acetylsalicylic acid and microembolic events detected by transcranial Doppler in symptomatic arterial stenoses. ( Blaser, T; Goertler, M; Krueger, S; Lutze, G; Wallesch, CW, 2001)
"Nine patients with recent transient ischemic attack or minor stroke of arterial origin were investigated."2.69Rapid decline of cerebral microemboli of arterial origin after intravenous acetylsalicylic acid. ( Baeumer, M; Blaser, T; Goertler, M; Jost, S; Kross, R; Lutze, G; Wallesch, CW, 1999)
"Initially, transient ischemic attack or cerebral infarction occurring in the distribution of the study artery and any transient ischemic attack, stroke, or death occurring in the perioperative period."2.68Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. ( , 1995)
"In addition, 6 transient ischemic attacks and 3 myocardial infarctions could be directly linked to CEA, for a total CEA event rate of 2."2.68An analysis of perioperative surgical mortality and morbidity in the asymptomatic carotid atherosclerosis study. ACAS Investigators. Asymptomatic Carotid Atherosclerosis Study. ( Broderick, JP; Cohen, SN; Dempsey, RJ; Ernst, CB; Hosking, JD; Moore, WS; Robertson, JT; Toole, JF; Young, B, 1996)
" Twenty-six patients were dosed for 2 weeks, 300 mg aspirin once daily and then for 2 weeks, 250 mg ticlopidine twice daily."2.68Asymptomatic circulating cerebral emboli and cerebral blood flow velocity under aspirin and ticlopidine in patients with cerebrovascular disease. ( Droste, DW; Kaps, M; Siemens, HJ; Sonne, M, 1996)
"The CASANOVA study (Carotid Artery Stenosis with Asymptomatic Narrowing: Operation Versus Aspirin) is a multicenter trial in 410 patients with asymptomatic stenosis (50-90%) of the internal carotid artery who were randomized after angiography."2.67Carotid surgery versus medical therapy in asymptomatic carotid stenosis. The CASANOVA Study Group. ( , 1991)
"We prospectively analyzed adverse effects of aspirin in a multicentered cooperative study undertaken to determine the role of endarterectomy in the treatment of asymptomatic carotid artery stenosis."2.67Adverse effects of aspirin in the treatment of asymptomatic carotid artery stenosis. The VA Cooperative Asymptomatic Carotid Artery Stenosis Study Group. ( Corson, JD; Hobson, RW; Krupski, WC; Rapp, JH; Weiss, DG, 1992)
"Carotid stenosis was confirmed by arteriography, which demonstrated at least 50% stenosis, measured by comparing the least transverse diameter of the stenosis on lateral arteriography."2.674. Current status of operative treatment for asymptomatic carotid stenosis. ( Hobson, RW; Towne, JB, 1994)
"Patients with carotid stenosis have a high frequency of asymptomatic coronary artery disease (CAD)."2.67Cardiac prognosis of patients with carotid stenosis and no history of coronary artery disease. Veterans Affairs Cooperative Study Group 167. ( Chimowitz, MI; Cohen, SL; Hobson, RW; Starling, MR; Weiss, DG, 1994)
"Patients suffering from carotid artery stenosis symptomatic or not."2.48Carotid endarterectomy plus medical therapy or medical therapy alone for carotid artery stenosis in symptomatic or asymptomatic patients: a meta-analysis. ( Guay, J; Ochroch, EA, 2012)
"Ischemic stroke is a common complication after CABG."2.44Prevention of ischemic stroke: surgery. ( Chaturvedi, S; Rajamani, K, 2007)
"Extracranial internal carotid artery stenosis (EICAS) accounts for approximately 25% of ischemic strokes, with an incidence as high as 10% in people aged > 80 years."2.44Multimodality management of carotid artery stenosis: reviewing the class-I evidence. ( McClelland, S, 2007)
"Twenty-three children had varicella at age 1."2.43Post-varicella arteriopathy of childhood: natural history of vascular stenosis. ( Armstrong, D; deVeber, G; Domi, T; Lanthier, S, 2005)
"The risk of TIA or stroke recurrence reaches 30-45%."2.42[Stenosis of the carotid arteries]. ( Kaźmierski, MK, 2003)
"The diagnosis of carotid stenosis is made after occurrence of a cerebral ischemic event or during an angiologic examination, mainly using Doppler/Duplex-sonography."2.42[Carotid stenosis: diagnosis, patient selection, therapy]. ( Barth, A, 2003)
"Triflusal is an antiplatelet agent structurally related to the salicylate group of compounds, but it is not derived from aspirin (acetylsalicylic acid)."2.40Triflusal. ( Goa, KL; McNeely, W, 1998)
" Furthermore, in assessing the potential benefits of long-term use of ASA for prophylactic purposes in these patients, one should also evaluate the side-effects and intolerance related to its chronic use, as well as its potential complications especially from a gastrointestinal perspective."2.39Aspirin in asymptomatic carotid disease. ( Côté, R, 1994)
"The majority presented with recurrent transient ischemic attacks/minor strokes within a single vascular territory over days to weeks."1.56Focal Cerebral Arteriopathy in Young Adult Patients With Stroke. ( Cronin, S; Fanning, N; McKenna, MC, 2020)
"All the patients presented with carotid artery stenosis >70% (North American Symptomatic Carotid Endarterectomy Trial [NASCET] criteria), which was symptomatic in 42 patients (transient ischemic attack, n = 32; minor stroke, n = 10) and asymptomatic in 146."1.46Dual Antiplatelet Therapy Does Not Increase the Risk of Bleeding After Carotid Endarterectomy: Results of a Prospective Study. ( Calio', FG; Illuminati, G; Masci, F; Pizzardi, G; Ricco, JB; Schneider, F, 2017)
"The early recurrence of neurological symptoms (NR) after urgent aggressive best medical therapy (BMT) in symptomatic carotid stenosis is not well documented."1.43Risk of early recurrent stroke in symptomatic carotid stenosis after best medical therapy and before endarterectomy. ( Ellemann, K; Gottschalksen, B; Owen-Falkenberg, A; Shahidi, S, 2016)
" The purpose of this study was to compare the efficacy and safety of clopidogrel combined with aspirin (CA) versus sarpogrelate combined with aspirin (SA) treatment in carotid endarterectomy (CEA) patients."1.43Effects of Sarpogrelate Combined with Aspirin in Patients Undergoing Carotid Endarterectomy in China: A Single-Center Retrospective Study. ( Gu, Y; Guo, J; Guo, L; Qi, L; Tong, Z; Wang, Z; Yu, H; Zhang, J, 2016)
" Long-term use of aspirin plus clopidorel after CAS did not decrease the risk of ischemic stroke, composite vascular events, or death during 6 months of follow-up."1.42Is Extended Duration of Dual Antiplatelet Therapy After Carotid Stenting Beneficial? ( Huang, JY; Jhang, KM; Jian, ZH; Ku, WY; Liaw, YP; Nfor, ON; Tung, YC, 2015)
"A total of 949 patients with cervical carotid artery stenosis were enrolled at 43 institutions in Japan; 934 who had undergone CAS with antiplatelet drugs and followed for 1 year were analyzed."1.40Prospective registry of carotid artery stenting in Japan--investigation on device and antiplatelet for carotid artery stenting. ( Ezura, M; Hyodo, A; Matsubara, Y; Matsumaru, Y; Matsumoto, Y; Miyachi, S; Nakamura, M; Okada, Y; Sakai, C; Sakai, N; Terada, T; Yamagami, H; Yokoi, H, 2014)
"In the Asymptomatic Carotid Artery Stenosis trial (1995), medical management was defined as aspirin in addition to adequate control of comorbidities."1.39Efficacy of contemporary medical management for asymptomatic carotid artery stenosis. ( Ahn, JE; Chang, J; Chun, L; Landsman, N; Patel, KK; Rhee, K, 2013)
"Onyx HD-500 is a liquid embolic used to treat intracranial aneurysms."1.39Continued concern about parent vessel steno-occlusive progression with Onyx HD-500 and the utility of quantitative magnetic resonance imaging in serial assessment. ( Alaraj, A; Aletich, VA; Amin-Hanjani, S; Carlson, AP; Charbel, FT, 2013)
"Aspirin resistance was more common in patients with MES (50% compared to 17."1.38Microembolic signals and aspirin resistance in patients with carotid stenosis. ( Dawson, J; Lees, KR; Quinn, T; Walters, MR, 2012)
"Cerebral infarction associated with ulcerative colitis is particularly rare, but clinically important because of its high morbidity and mortality."1.37Recurrent ischemic stroke in a patient with ulcerative colitis and high levels of lipoprotein (a). ( Bramanti, P; Calabrò, RS; Gervasi, G; Pezzini, A; Pollicino, P, 2011)
"Freedom from repeat intervention for re-recurrence was 89% in the CEA group and 95% in the CAS group (p=0."1.36Redo surgery or carotid stenting for restenosis after carotid endarterectomy: results of two different treatment strategies. ( Attigah, N; Böckler, D; Deyle, C; Geisbüsch, P; Hartmann, M; Külkens, S; Ringleb, P, 2010)
"Aspirin was without significant effect."1.34Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques. ( Brandl, R; Deckmyn, H; Penz, SM; Reininger, AJ; Siess, W; Toth, O, 2007)
"Aspirin resistance was defined as closure time (CT) less than the upper limit of normal (158 s collagen/epinephrine agonist; 118 s collagen/adenosine diphosphate (ADP) agonist)."1.33Point of care testing of aspirin resistance in patients with vascular disease. ( Appleberg, M; Lewis, DR; Ward, CM; Wong, S, 2006)
"To report procedure-related complications and neurological adverse events of unprotected over-the-wire (OTW) and protected rapid exchange (RX) carotid artery stenting (CAS) in a single-center patient series during an 8-year period."1.33Procedure-related complications and early neurological adverse events of unprotected and protected carotid stenting: temporal trends in a consecutive patient series. ( Ahmadi, A; Amighi, J; Boltuch, J; Dick, P; Minar, E; Mlekusch, W; Sabeti, S; Schillinger, M; Schlager, O, 2005)
"Acute in-stent thrombosis is a well-known complication of carotid angioplasty and stenting (CAS) and often due to resistance to or inadequate treatment with platelet-inhibiting agents."1.33Late in-stent thrombosis following carotid angioplasty and stenting. ( Buhk, JH; Knauth, M; Wellmer, A, 2006)
"A plaque embolism was excluded clinically and in the contrast-medium intensified MRT 5 days after the intervention in 79/81 (97."1.32[Outpatient primary stent-angioplasty in symptomatic internal carotid artery stenoses]. ( Andresen, R; Brinckmann, W; Roth, M, 2003)
"Treatment of dissecting pseudoaneurysms of the distal cervical internal carotid artery with preservation of the parent artery by using stents or coils has become routine."1.32Stent-coil treatment of a distal internal carotid artery dissecting pseudoaneurysm on a redundant loop by use of a flexible, dedicated nitinol intracranial stent. ( Graybeal, CL; Pride, GL; Purdy, P; Rappard, G; Replogle, RE; White, J, 2004)
"An 18-year-old Saudi male with systemic lupus erythematosus (SLE) presented with mild right hemiparesis, followed by recurrent ischemic stroke."1.31Systemic lupus erythematosus associated with moyamoya syndrome. ( Al Rayes, HM; El Ramahi, KM, 2000)
" We present several illustrative cases in which platelet monitoring with the Rapid Platelet Function Assay (RPFA, Accumetrics) was used to guide dosing of a glycoprotein (GP) IIb/IIIa inhibitor for coronary and peripheral intervention among patients at increased bleeding risk."1.31Clinical application of procedural platelet monitoring during percutaneous coronary intervention among patients at increased bleeding risk. ( Chew, DP; Moliterno, DJ; Mukherjee, D; Raymond, RE; Robbins, M; Yadav, JS, 2001)
"Macrophage density in carotid artery plaques classified by B-mode ultrasound imaging as echolucent (n = 56), intermediate (n = 25), or echorich (n = 25) was 1."1.31Macrophages are associated with lipid-rich carotid artery plaques, echolucency on B-mode imaging, and elevated plasma lipid levels. ( Bentzon, J; Falk, E; Grønholdt, ML; Nordestgaard, BG; Sillesen, H; Wiebe, BM; Zhou, J, 2002)
"Most of cerebral infarctions were observed in the hemisphere, ipsilateral to the irradiated carotid artery."1.29Effect of Y-20811, a thromboxane synthetase inhibitor, on photochemically induced cerebral embolism in rabbits. ( Fujimura, M; Mikashima, H, 1993)

Research

Studies (219)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's60 (27.40)18.2507
2000's77 (35.16)29.6817
2010's60 (27.40)24.3611
2020's22 (10.05)2.80

Authors

AuthorsStudies
Marcaccio, CL2
Patel, PB2
Liang, P2
Rastogi, V2
Stangenberg, L2
Jim, J2
Schneider, PA2
Schermerhorn, ML2
Subramanian, A1
Delaney, S1
Murphy, SJX3
Smith, DR1
Offiah, C1
McMahon, J1
de Borst, GJ3
Naylor, AR4
Hamilton, G4
Kinsella, JA3
McCabe, DJH4
Ku, JC1
Taslimi, S1
Zuccato, J1
Pasarikovski, CR1
Nasr, N1
Chechik, O1
Chisci, E1
Bissacco, D1
Larrue, V3
Rabinovich, Y1
Michelagnoli, S1
Settembrini, PG1
Priola, SM1
Cusimano, MD1
Yang, VXD1
Macdonald, RL1
Patel, RJ1
Marmor, R1
Dakour, H1
Elsayed, N1
Ramachandran, M1
Malas, MB1
Chen, P1
Lazar, A1
Ding, J1
Siracuse, JJ1
Patel, VI3
Morrissey, NJ1
Marnat, G1
Finistis, S1
Moreno, R1
Sibon, I1
Pop, R1
Mazighi, M2
Clarençon, F1
Rosso, C1
Dargazanli, C1
Darcourt, J1
Olivot, JM2
Boulouis, G1
Janot, K1
Moulin, S1
Bourcier, R1
Consoli, A1
Richard, S1
Arquizan, C1
Vannier, S1
Richter, S1
Gentric, JC1
Papagiannaki, C1
Naggara, O1
Eker, OF1
Lapergue, B1
Caroff, J1
Gory, B1
Wyers, MC1
Simonte, G1
Guglielmini, G1
Falcinelli, E1
Isernia, G1
Mezzasoma, AM1
Gresele, P1
Lenti, M1
Manunga, J1
Pedersen, C1
Stanberry, L1
Pai, A1
Skeik, N1
Sullivan, TM1
Clezar, CN1
Flumignan, CD1
Cassola, N1
Nakano, LC1
Trevisani, VF1
Flumignan, RL1
Perera, KS1
Ng, KKH1
Nayar, S1
Catanese, L1
Dyal, L1
Sharma, M1
Connolly, SJ1
Yusuf, S1
Bosch, J1
Eikelboom, JW1
Hart, RG4
Lim, ST1
Tierney, S2
Egan, B2
Feeley, TM2
Murphy, SM1
Walsh, RA1
Collins, DR1
Coughlan, T2
O'Neill, D2
Harbison, JA2
Madhavan, P2
O'Neill, SM2
Colgan, MP2
Cox, D1
Moran, N2
Meaney, JF1
Murias, E1
Vega, P1
Lopez-Cancio, E1
Peña, J1
Morales, E1
Benavente, L1
González, M1
Larrosa, D1
Rico, M1
Riesco, N1
Cadenas, M1
Jimenez, JM1
Chaviano, J1
Saiz, A1
Calleja, S1
Arias, F1
McKenna, MC1
Fanning, N1
Cronin, S1
Wu, H1
Song, H1
Dou, L1
Gao, B1
Pan, Y1
Dong, M1
Chen, Q1
Li, J1
Song, L1
Liu, C1
Li, B1
Chu, W1
Delvoye, F1
Maier, B1
Escalard, S1
Labreuche, J1
Thion, LA1
Aknouche, S1
Hebert, S1
Redjem, H1
Smajda, S1
Ciccio, G1
Allard, J1
Sabben, C1
Obadia, M1
Maertens de Noordhout, A1
Blanc, R1
Piotin, M1
Desilles, JP1
Hummel, T2
Meves, SH2
Breuer-Kaiser, A1
Düsterwald, JO1
Mühlberger, D2
Mumme, A2
Neubauer, H2
Horev, A2
Zlotnik, Y1
Borodetsky, V1
Biederko, R1
Star, M1
Zvenigorodsky, V1
Shelef, I1
Ifergane, G1
Honig, A1
Sacagiu, T1
Filioglo, A1
Simaan, N1
Kalish, Y1
Gomori, JM1
Leker, RR1
Cohen, JE2
Yaghi, S1
de Havenon, A1
Rostanski, S1
Kvernland, A1
Mac Grory, B1
Furie, KL1
Kim, AS1
Easton, JD2
Johnston, SC3
Henninger, N1
Ciolli, L1
Lelli, N1
Rosafio, F1
Maffei, S1
Sacchetti, F1
Vandelli, L1
Dell'Acqua, ML1
Picchetto, L1
Borzì, GM1
Ricceri, R1
Pentore, R1
Tondelli, M1
Vandelli, G1
Rodríguez-Villatoro, N1
Meletti, S1
Zini, A1
Vallone, S1
Bigliardi, G1
Hsu, CH1
Yu, SM1
Lau, SC1
Chen, YL1
Pei, D1
Liu, IC1
Oliver Tobin, W1
Ronan Collins, D1
Doherty, CP1
Moore, DJ1
Saqqur, M1
Murphy, RP1
Amarenco, P1
Albers, GW1
Denison, H1
Evans, SR1
Held, P1
Hill, MD1
Jonasson, J1
Kasner, SE1
Ladenvall, P1
Minematsu, K1
Molina, CA1
Wang, Y1
Wong, KSL1
Tanaskovic, S1
Radak, D1
Aleksic, N1
Calija, B1
Maravic-Stojkovic, V1
Nenezic, D1
Ilijevski, N1
Popov, P1
Vucurevic, G1
Babic, S1
Matic, P1
Gajin, P1
Vasic, D1
Rancic, Z1
Gruber, P1
Hlavica, M1
Berberat, J1
Victor Ineichen, B1
Diepers, M1
Nedeltchev, K2
Kahles, T1
Remonda, L1
Ricco, JB2
Sillesen, H3
Kakkos, S1
Halliday, A2
Vega de Ceniga, M1
Christodoulou, C1
Economides, C1
D'Cruz, D1
Kolos, I1
Loukianov, M1
Dupik, N1
Boytsov, S1
Deev, A1
Sorkin, GC1
Dumont, TM1
Wach, MM1
Eller, JL1
Mokin, M1
Natarajan, SK1
Baxter, MS1
Snyder, KV1
Levy, EI2
Hopkins, LN1
Siddiqui, AH1
Conrad, MF3
Boulom, V1
Baloum, V1
Mukhopadhyay, S1
Garg, A1
Cambria, RP3
Wadiwala, MF1
Kamal, AK1
Turan, TN3
Smock, A1
Chimowitz, MI4
Chang, J1
Ahn, JE1
Landsman, N1
Rhee, K1
Chun, L1
Patel, KK1
Derdeyn, CP3
Lynn, MJ2
Fiorella, D2
Janis, LS2
Montgomery, J2
Nizam, A1
Lane, BF2
Lutsep, HL2
Barnwell, SL1
Waters, MF1
Hoh, BL1
Hourihane, JM1
Alexandrov, AV1
Harrigan, MR1
Chiu, D1
Klucznik, RP1
Clark, JM1
McDougall, CG1
Johnson, MD1
Pride, GL2
Lynch, JR1
Zaidat, OO1
Rumboldt, Z1
Cloft, HJ1
Nakagawa, I3
Wada, T3
Park, HS3
Nishimura, F1
Yamada, S2
Nakagawa, H1
Kichikawa, K3
Nakase, H3
Bakri, SJ1
Luqman, A1
Pathik, B1
Chandrasekaran, K1
Mansoor, AH1
Mujtaba, MT1
Silver, B1
Alcocer, F1
Novak, Z1
Combs, BR1
Lowman, B1
Passman, MA1
Mujib, M1
Jordan, WD1
Sakai, N1
Yamagami, H1
Matsubara, Y1
Ezura, M1
Hyodo, A1
Matsumaru, Y1
Miyachi, S1
Okada, Y1
Terada, T1
Yokoi, H1
Nakamura, M1
Matsumoto, Y1
Sakai, C1
Ma, B1
Hang, L1
Chen, G1
Du, Y1
Abbott, A1
Geroulakos, G1
Mikhailidis, DP1
Nicolaides, AN1
Veith, FJ2
Michalczyk, MJ1
Opalacz, A1
LaMuraglia, GM1
Yan, Y1
Yuan, Y1
Liang, L1
Chen, T1
Shen, Y1
Zhong, C1
Paraskevas, KI1
Lewszuk, AJ1
Postuła, M1
Madycki, G1
Staszkiewicz, W1
Opolski, G1
Eberhardt, A1
Amato, B1
Compagna, R1
Amato, M1
Gallelli, L1
de Franciscis, S1
Serra, R1
Batchelder, A1
Hunter, J1
Cairns, V1
Sandford, R1
Munshi, A1
Nishi, H1
Nakahara, I1
Matsumoto, S1
Hashimoto, T1
Ohta, T1
Sadamasa, N1
Ishibashi, R1
Gomi, M1
Saka, M1
Miyata, H1
Watanabe, S1
Okata, T1
Sonoda, K1
Kouge, J1
Ishii, A2
Nagata, I1
Kira, J1
Cotsonis, GA1
Jhang, KM1
Huang, JY1
Nfor, ON1
Jian, ZH1
Tung, YC1
Ku, WY1
Liaw, YP1
Yokoyama, S2
Hironaka, Y1
Motoyama, Y2
Takayama, K1
Huibers, A1
Bulbulia, R1
Coppi, G1
Shahidi, S1
Owen-Falkenberg, A1
Gottschalksen, B1
Ellemann, K1
Rüdiger, K1
Mügge, A1
Burkert, B1
Guo, J1
Gu, Y1
Guo, L1
Yu, H1
Qi, L1
Tong, Z1
Zhang, J1
Wang, Z1
Deng, QQ1
Tang, J1
Chen, C2
Markus, H1
Huang, YN2
Zhao, H1
Ratanakorn, D2
Wong, KS3
Fu, JH1
Illuminati, G1
Schneider, F1
Pizzardi, G1
Masci, F1
Calio', FG1
Turtzo, LC1
McCullough, LD1
Guerra, M1
Mota, JC1
Veloso, M1
Gama, V1
Vouga, L1
Yamasaki, H1
Matsubara, S2
Sasaki, I1
Nagahiro, S1
Beckman, JA1
Tautenhahn, J1
Meyer, F1
Pech, M1
Michael, L1
Goertler, M3
Halloul, Z1
Attigah, N1
Külkens, S1
Deyle, C1
Ringleb, P1
Hartmann, M1
Geisbüsch, P1
Böckler, D1
Fu, J1
Chang, HM1
Suwanwela, NC1
Han, Z1
Tan, KS1
Chollate, P1
Zhao, Y1
Koh, A1
Hao, Q1
Markus, HS4
Hennerici, MG2
Bots, ML1
Ford, I1
Laurent, S1
Touboul, PJ1
Itshayek, E1
Ogasawara, K1
Ahn, CM1
Hong, SJ1
Park, JH1
Kim, JS1
Lim, DS1
Farina, A1
Spinazzola, A1
Abbiati, G1
Arpini, MT1
Bergamaschi, L1
Riva, A1
Berticelli, P1
Poisson, S1
Calabrò, RS1
Pezzini, A1
Gervasi, G1
Pollicino, P1
Bramanti, P1
Leung, TW1
Yu, SC1
Dawson, J1
Quinn, T1
Lees, KR2
Walters, MR1
Drazin, D1
Choulakian, A1
Nuño, M1
Kornbluth, P1
Alexander, MJ1
Pelegrín, L1
Mesquida, M1
Rey, A1
Sánchez-Dalmau, B1
Frohman, L1
Inoue, Y1
Krings, T1
Rogers, RK1
Sakhuja, R1
Margey, R1
Stone, JH1
Rosenfield, K1
Jaff, MR1
Guay, J1
Ochroch, EA1
Schoenefeld, E1
Donas, K1
Radicke, A1
Osada, N1
Austermann, M1
Torsello, G1
Vellimana, AK1
Kadkhodayan, Y1
Rich, KM1
Cross, DT1
Moran, CJ1
Zazulia, AR1
Lee, JM1
Chicoine, MR1
Dacey, RG1
Zipfel, GJ1
Carlson, AP1
Alaraj, A1
Amin-Hanjani, S1
Charbel, FT1
Aletich, VA1
Spence, JD2
Lopez-Yunez, AM1
Baumgartner, RW3
Georgiadis, D1
Haberl, RL1
Stiefelhagen, P1
Diener, HC3
Kaźmierski, MK1
Andresen, R1
Roth, M1
Brinckmann, W1
Arnold, M1
Lyrer, P1
Norrving, B1
Barth, A1
Replogle, RE1
Rappard, G1
Graybeal, CL1
White, J1
Purdy, P1
McKevitt, FM2
Macdonald, S1
Venables, GS3
Cleveland, TJ2
Gaines, PA3
Warlow, C1
Webster, SE1
Payne, DA1
Jones, CI1
Hayes, PD1
Bell, PR1
Goodall, AH1
Sattler, KJ1
Woodrum, JE1
Galili, O1
Olson, M1
Samee, S1
Meyer, FB1
Zhu, XY1
Lerman, LO1
Lerman, A1
Schellinger, PD1
Hacke, W2
Habets, PC1
Lanthier, S1
Armstrong, D1
Domi, T1
deVeber, G1
Sherif, C1
Dick, P2
Sabeti, S2
Mlekusch, W2
Amighi, J2
Ahmadi, R1
Lalouschek, W1
Minar, E2
Schillinger, M2
Droste, DW3
Kaps, M3
Siebler, M2
Ringelstein, EB2
Randall, MS1
Tan, KT1
Larroche, C1
Chadenat, ML1
Chaunu, MP1
Abad, S1
Casassus, P1
Dhôte, R1
McCabe, DJ1
Harrison, P1
Mackie, IJ1
Sidhu, PS1
Purdy, G1
Lawrie, AS1
Watt, H1
Machin, SJ1
Brown, MM1
Chaturvedi, S2
Bruno, A1
Feasby, T1
Holloway, R1
Benavente, O2
Cohen, SN4
Cote, R3
Hess, D1
Saver, J1
Stern, B1
Wilterdink, J1
Ouriel, K1
Wholey, MH1
Fayad, P1
Katzen, BT1
Whitlow, P1
Frentzko, M1
Kuntz, RE1
Wechsler, L1
Hopkins, N1
Satler, L1
Mishkel, G1
Yadav, JS4
Boltuch, J1
Schlager, O1
Ahmadi, A1
Imray, CH1
Higman, DJ1
Marshall, C1
Burgstahler, C1
Reimann, A1
Beck, T1
Kuettner, A1
Heuschmid, M1
Kopp, AF1
Schroeder, S1
Dittrich, R1
Ritter, MA1
Lees, K1
Nabavi, DG1
Akaji, K1
Tanizaki, Y1
Hiraga, K1
Akiyama, T1
Dembo, T1
Dalainas, I1
Nano, G1
Kikuta, K1
Takagi, Y1
Arakawa, Y1
Miyamoto, S1
Hashimoto, N1
Buhk, JH1
Wellmer, A1
Knauth, M1
Assadian, A2
Eidher, U1
Senekowitsch, C1
Rotter, R1
Löchli, S1
Hagmüller, GW2
Knöbl, P1
Roffi, M2
Onizuka, M1
Kazekawa, K1
Nagata, S1
Tsutsumi, M1
Aikawa, H1
Tomokiyo, M1
Iko, M1
Kodama, T1
Nii, K1
Tanaka, A1
Kurukulasuriya, LR1
Govindarajan, G1
Sowers, J1
Wong, S1
Ward, CM1
Appleberg, M1
Lewis, DR1
Grond, M1
Holten, KB1
Viñuela, F1
Murayama, Y1
Yuki, I1
Nien, YL1
Yeh, DT1
Vinters, HV1
Kramer, J1
Abraham, J1
Teven, CM1
Jones, PA1
Telman, G1
Kouperberg, E1
Schlesinger, I1
Yarnitsky, D1
Kahraman, G1
Sahin, T1
Kilic, T1
Baytugan, NZ1
Agacdiken, A1
Ural, E1
Ural, D1
Komsuoglu, B1
Topakian, R1
Nussbaumer, K1
Trenkler, J1
Aichner, FT1
Pyun, HW1
Lee, DH1
Kwon, SU1
Lee, JH1
Choi, CG1
Kim, SJ1
Suh, DC1
Penz, SM1
Reininger, AJ1
Toth, O1
Deckmyn, H1
Brandl, R1
Siess, W1
Inoue, T1
Shimizu, H1
Okabe, H1
Tominga, T1
Lax, J1
Meixner-Loicht, U1
Bayer, PM1
Hübl, W1
Rajamani, K1
McClelland, S1
Rothwell, PM2
Gao, L1
Wang, PP1
Liu, Q1
Andreozzi, GM1
Arosio, E1
Martini, R1
Verlato, F1
Visonà, A1
Robicsek, F1
Battista, RN1
Abrahamowicz, M1
Langlois, Y1
Bourque, F1
Mackey, A1
Brott, T2
Toole, JF3
Schelp, R1
Bickel, A1
Kolominsky, P1
Schweiger, H1
Gorelick, PB1
Rohack, JJ1
Solomon, DH2
Feinberg, WM1
Moore, WS3
Barnett, HJ1
Beebe, HG1
Bernstein, EF2
Brener, BJ1
Caplan, LR1
Day, A1
Goldstone, J2
Hobson, RW7
Chaudhuri, A1
Medhekar, TP1
Stähelin, HB1
Evison, J1
Seiler, WO1
Towne, JB2
Weiss, DG5
Cohen, SL1
Starling, MR1
Lagneau, P1
Chimowitz, M1
Fujimura, M1
Mikashima, H1
Bischof, G1
Pratschner, T1
Kail, M1
Mittlböck, M1
Turkof, E1
Puig, S1
Polterauer, P1
Kretschmer, G1
Hansen, F1
Lindblad, B1
Persson, NH1
Bergqvist, D1
Britton, M1
Fields, WS1
Wright, CB1
Krupski, WC2
Hertzer, NR1
Frey, JL1
Browner, WS1
Creutzig, A2
Ranke, C2
Goldstein, LB1
Bonito, AJ1
Matchar, DB1
Duncan, PW1
Samsa, GP1
Sivaguru, A1
Beard, JD1
Diethrich, EB1
Ndiaye, M1
Reid, DB1
Martín, R1
Donati, F1
Regli, F1
Regli, L1
Bogousslavsky, J1
Sonne, M1
Siemens, HJ1
Young, B1
Robertson, JT1
Ernst, CB1
Broderick, JP1
Dempsey, RJ1
Hosking, JD1
Valentin, JP1
Vieu, S1
Bertolino, F1
Fauré, P1
John, GW1
Biller, J2
Calvey, TA1
Gough, MJ1
McNeely, W1
Goa, KL1
Molloy, J1
Martin, JF1
Baskerville, PA1
Fraser, SC1
Baeumer, M1
Kross, R1
Blaser, T2
Lutze, G2
Jost, S1
Wallesch, CW2
Mattle, HP1
Schroth, G1
Riggs, PN1
DeWeese, JA1
Loftus, CM1
Patel, ST1
Haser, PB1
Korn, P1
Bush, HL1
Deitch, JS1
Kent, KC1
Shah, MV1
Masson, C1
Vallée, JP1
Klijn, CJ1
van Buren, PA1
Kappelle, LJ1
Tulleken, CA1
Eikelboom, BC1
Algra, A1
van Gijn, J1
Ragni, M2
Golino, P2
Cirillo, P1
Scognamiglio, A1
Piro, O1
Esposito, N1
Battaglia, C1
Botticella, F1
Ponticelli, P1
Ramunno, L1
Chiariello, M2
Steinberg, J1
Baker, WH1
Howard, VJ1
Howard, G1
El Ramahi, KM1
Al Rayes, HM1
Krueger, S1
Mukherjee, D2
Chew, DP2
Robbins, M1
Raymond, RE1
Moliterno, DJ1
Weisser, B1
Düsing, R1
Mengden, T1
Bhatt, DL1
Kapadia, SR1
Bajzer, CT1
Ziada, KM1
Topol, EJ1
Grønholdt, ML1
Nordestgaard, BG1
Bentzon, J1
Wiebe, BM1
Zhou, J1
Falk, E1
Prieto, AR1
Ma, H1
Huang, R1
Khan, G1
Schwartz, KA1
Hage-Korban, EE1
Schmaier, AH1
Davis, JM1
Hasan, AA1
Abela, GS1
Rapp, JH1
Corson, JD1
Hecker, H1
Alexander, K1
Harker, LA1
Dilley, RB1
Scala, TE1
Sise, MJ1
Hye, RJ1
Otis, SM1
Roberts, RS1
Gent, M1
Schulze, HE1
Ebner, A1
Besinger, UA1
Wilcox, M1
Willette, RN1
Sauermelch, CF1
Rycyna, R1
Sarkar, S1
Feuerstein, GZ1
Nichols, AJ1
Ohlstein, EH1
Ambrosio, G1
Pascucci, I1
Russolillo, E1
Bolt, M1
Floeter, MK1
Leblhuber, F1
Költringer, P1
Reisecker, F1
Duprez, D1
Clement, DL1

Clinical Trials (23)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Controlled Trial of Rivaroxaban for the Prevention of Major Cardiovascular Events in Patients With Coronary or Peripheral Artery Disease (COMPASS - Cardiovascular OutcoMes for People Using Anticoagulation StrategieS).[NCT01776424]Phase 327,395 participants (Actual)Interventional2013-02-28Completed
A Randomised, Double-Blind, Placebo-Controlled, International, Multicentre, Phase III Study to Investigate the Efficacy and Safety of Ticagrelor and ASA Compared With ASA in the Prevention of Stroke and Death in Patients With Acute Ischaemic Stroke or Tra[NCT03354429]Phase 311,016 participants (Actual)Interventional2018-01-22Completed
A Randomised, Double-Blind, Multinational Study to Prevent Major Vascular Events With Ticagrelor Compared to Aspirin (ASA) in Patients With Acute Ischaemic Stroke or TIA.[NCT01994720]Phase 313,307 participants (Actual)Interventional2014-01-07Completed
Carotid Endarterectomy Versus Optimal Medical Treatment of Asymptomatic High Grade Carotid Artery Stenosis[NCT00805311]Phase 4400 participants (Actual)Interventional2009-04-30Terminated (stopped due to Due to the clear advantage of carotid endarterectomy)
Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis[NCT00576693]Phase 3451 participants (Actual)Interventional2008-10-31Completed
Stroke Imaging Package Study of Intracranial Atherosclerosis[NCT03719820]550 participants (Anticipated)Observational [Patient Registry]2018-11-14Recruiting
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging[NCT05907629]300 participants (Anticipated)Observational2023-12-30Not yet recruiting
Evolocumab Added to Statin Therapy in Patients With Symptomatic Intracranial Atherosclerotic Stenosis (EAST-ICAS)---a Pilot Study[NCT05741086]Phase 380 participants (Anticipated)Interventional2023-04-15Recruiting
China Angioplasty & Stenting for Symptomatic Intracranial Severe Stenosis (CASSISS): a New, Prospective, Multi-center, Randomized Controlled Trial in China[NCT01763320]Phase 3380 participants (Actual)Interventional2014-03-05Completed
MULTIcentric Study About RESistance to CLOpidogrel in Dual Antiplatelet Therapy for Carotid Stenting[NCT05566301]1,140 participants (Anticipated)Observational2021-09-02Recruiting
Carotid Stenosis Management During COVID-19 Era - Best Medical Intervention Alone (CASCOM Pilot Study): A Prospective Observational Study[NCT04947046]120 participants (Anticipated)Observational2020-03-11Recruiting
Antiplatelet Therapy in Acute Mild-Moderate Ischemic Stroke (ATAMIS): a Parallel Randomized, Open-label, Multicenter, Prospective Study[NCT02869009]Phase 33,000 participants (Actual)Interventional2016-11-30Completed
Association of PeriOPerative Aspirin-ResisTance and CardioVascular Outcome[NCT04053894]220 participants (Anticipated)Observational2019-08-31Not yet recruiting
Focal Cerebral Arteriopathy Steroid Trial[NCT06040255]Phase 480 participants (Anticipated)Interventional2023-10-01Not yet recruiting
Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Phase II, Multicentre; Randomised, Dose-finding, Double-blind and Placebo Controlled Superiority Study With Parallel Groups[NCT01645306]Phase 2158 participants (Actual)Interventional2013-03-08Completed
Prevalence of Aspirin Resistance in Ischemic Stroke Patients at Assiut University Hospital[NCT05151263]133 participants (Anticipated)Observational2023-11-01Not yet recruiting
Body Cooling During Carotid Endarterectomy: No-profit, Open, Mono-centric, Feasibility Study[NCT02629653]10 participants (Actual)Interventional2013-12-31Completed
Evaluation of Diagnostic and Predictive Capabilities of Novel Application of Carotid Carotid Stenosis Pressure Gradient Measurement in Patients Undergoing Percutaneous Carotid Angioplasty and Stenting (CAS).[NCT06123767]200 participants (Anticipated)Interventional2024-01-01Not yet recruiting
Risk Factors for Complications After Carotid Endarterectomy: A Multicenter International Observational Study[NCT03788980]10 participants (Actual)Observational2018-04-13Terminated (stopped due to Lack of funding and resources)
Radial Versus Femoral Access For Carotid Artery Stenting In Patients With Carotid-Artery Stenosis :a Prospective, Randomized, Multicenter, Noninferiority Trial[NCT05416853]2,688 participants (Anticipated)Interventional2022-07-04Recruiting
Neovascularization Induced by Mechanical Barrier disrUption and Systemic Erythropoietin in Patients With Cerebral Perfusion Deficits (NIMBUS Trial)[NCT02603406]Phase 244 participants (Actual)Interventional2016-07-15Completed
Evaluation of Neurological Outcome in Patients Undergoing Cerebral Angiography and Revascularization Using Angioplasty and Stent-Supported Angioplasty[NCT00597974]108 participants (Actual)Observational2003-09-30Completed
[NCT00000527]Phase 20 participants Interventional1986-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

All-cause Mortality

Count of participants and time from randomization to death by all cause were evaluated. Hazard ratios were calculated and reported as statistical analysis. (NCT01776424)
Timeframe: For each participants, death by any cause after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.

InterventionParticipants (Count of Participants)
Rivaroxaban 2.5mg + Aspirin 100mg313
Rivaroxaban 5mg + Aspirin Placebo366
Rivaroxaban Placebo + Aspirin 100mg378

All-cause Mortality in LTOLE Part

Count of participants from COMPASS LTOLE initiation visit to death by all cause were evaluated. LTOLE: long-term open-lable extension (NCT01776424)
Timeframe: For each participants, death by any cause after COMPASS LTOLE initiation visit up until the the last LTOLE part contact date was considered. The mean time in follow-up until that date was 428 days.

InterventionParticipants (Count of Participants)
LTOLE Part: Rivaroxaban 2.5mg + Aspirin 100mg282

The First Occurrence of MI, Ischemic Stroke, ALI, or Cardiovascular (CV) Death

Count of participants and time from randomization to the first occurrence of MI, ischemic stroke, ALI, or CV death were evaluated. Hazard ratios were calculated and reported as statistical analysis. (NCT01776424)
Timeframe: For each participant, the first occurrence of MI, ischemic stroke, ALI, or CV death after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.

InterventionParticipants (Count of Participants)
Rivaroxaban 2.5mg + Aspirin 100mg389
Rivaroxaban 5mg + Aspirin Placebo453
Rivaroxaban Placebo + Aspirin 100mg516

The First Occurrence of Myocardial Infarction (MI), Ischemic Stroke, Acute Limb Ischemia (ALI), or Coronary Heart Disease (CHD) Death

Count of participants and time from randomization to the first occurrence of MI, ischemic stroke, ALI, or CHD death were evaluated. Hazard ratios were calculated and reported as statistical analysis. (NCT01776424)
Timeframe: For each participant, the first occurrence of MI, ALI, or CHD death after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.

InterventionParticipants (Count of Participants)
Rivaroxaban 2.5mg + Aspirin 100mg329
Rivaroxaban 5mg + Aspirin Placebo397
Rivaroxaban Placebo + Aspirin 100mg450

The First Occurrence of the Composite Primary Efficacy Outcome, Myocardial Infarction (MI), Stroke, or Cardiovascular (CV) Death

Count of participants and time from randomization to the first occurrence of the composite primary efficacy outcome, MI, stroke, or CV death were evaluated. Hazard ratios were calculated and reported as statistical analysis. (NCT01776424)
Timeframe: For each participant, the first occurrence of the composite primary efficacy outcome after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.

InterventionParticipants (Count of Participants)
Rivaroxaban 2.5mg + Aspirin 100mg379
Rivaroxaban 5mg + Aspirin Placebo448
Rivaroxaban Placebo + Aspirin 100mg496

The First Occurrence of the Composite Primary Efficacy Outcome, Myocardial Infarction (MI), Stroke, or Cardiovascular (CV) Death in LTOLE Part

Count of participants from COMPASS LTOLE initiation visit to the first occurrence of the composite primary efficacy outcome, MI, stroke, or CV death were evaluated. LTOLE: long-term open-lable extension (NCT01776424)
Timeframe: For each participant, the first occurrence of the composite primary efficacy outcome after from COMPASS LTOLE initiation visit up until last LTOLE part contact date was considered. The mean time in follow-up was 428 days.

InterventionParticipants (Count of Participants)
LTOLE Part: Rivaroxaban 2.5mg + Aspirin 100mg353

The First Occurrence of the Primary Safety Outcome Major Bleeding Based on a Modification of the International Society on Thrombosis and Haemostasis (ISTH) Criteria

"Modified ISTH major bleeding is defined as: i) Fatal bleeding, or ii) Symptomatic bleeding in a critical area or organ, such as intraarticular, intracranial, intramuscular with compartment syndrome, intraocular, intraspinal, liver, pancreas, pericardial, respiratory, retroperitoneal, adrenal gland or kidney; or bleeding into the surgical site requiring reoperation, or iii) Bleeding leading to hospitalization (major bleeding also includes presentation to an acute care facility with discharge on the same day).~Count of participants and time from randomization to the first occurrence of the primary safety outcome major bleeding were evaluated. Hazard ratios were calculated and reported as statistical analysis." (NCT01776424)
Timeframe: For each participant, the first occurrence of modified ISTH major bleeding after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.

InterventionParticipants (Count of Participants)
Rivaroxaban 2.5mg + Aspirin 100mg288
Rivaroxaban 5mg + Aspirin Placebo255
Rivaroxaban Placebo + Aspirin 100mg170

The First Occurrence of the Primary Safety Outcome Major Bleeding Based on a Modification of the International Society on Thrombosis and Haemostasis (ISTH) Criteria in LTOLE Part

"Modified ISTH major bleeding is defined as: i) Fatal bleeding, or ii) Symptomatic bleeding in a critical area or organ, such as intraarticular, intracranial, intramuscular with compartment syndrome, intraocular, intraspinal, liver, pancreas, pericardial, respiratory, retroperitoneal, adrenal gland or kidney; or bleeding into the surgical site requiring reoperation, or iii) Bleeding leading to hospitalization (major bleeding also includes presentation to an acute care facility with discharge on the same day).~Count of participants from COMPASS LTOLE initiation visit to the first occurrence of the primary safety outcome major bleeding was evaluated. LTOLE: long-term open-lable extension" (NCT01776424)
Timeframe: For each participant, the first occurrence of modified ISTH major bleeding from COMPASS LTOLE initiation visit up until 2 days after the last treatment in LTOLE part was considered. The mean time in follow-up was 421 days.

InterventionParticipants (Count of Participants)
LTOLE Part: Rivaroxaban 2.5mg + Aspirin 100mg138

Bleeding Event That Fulfils Serious Adverse Event Criteria and is Categorised as GUSTO Moderate/Severe

Participants with bleeding event that fulfils serious adverse event criteria and is categorised as GUSTO Moderate/Severe. GUSTO is a bleeding scale (GUSTO = Global Utilization of Streptokinase and Tissue plasminogen activator for Occluded coronary arteries). GUSTO Severe bleeding is defined as any of the following: (1) fatal bleeding, (2) intracranial bleeding, or (3) bleeding that caused haemodynamic compromise requiring intervention. GUSTO Moderate bleeding is a bleeding requiring transfusion of whole blood or packed red blood cells without haemodynamic compromise (NCT03354429)
Timeframe: From randomisation (day 1) to visit 3 (day 30-34)

InterventionParticipants (Count of Participants)
TICAGRELOR36
PLACEBO11

Bleeding Event That Fulfils Serious Adverse Event Criteria and is Categorised as GUSTO Severe

Participants with bleeding event that fulfils serious adverse event criteria and is categorised as GUSTO Severe. GUSTO is a bleeding scale (GUSTO = Global Utilization of Streptokinase and Tissue plasminogen activator for Occluded coronary arteries). GUSTO Severe bleeding is defined as any of the following: (1) fatal bleeding, (2) intracranial bleeding, or (3) bleeding that caused haemodynamic compromise requiring intervention (NCT03354429)
Timeframe: From randomisation (day 1) to visit 3 (day 30-34)

InterventionParticipants (Count of Participants)
TICAGRELOR28
PLACEBO7

Composite of Subsequent Stroke or Death

Participants with subsequent stroke or death (NCT03354429)
Timeframe: From randomisation (day 1) to visit 3 (day 30-34)

InterventionParticipants (Count of Participants)
TICAGRELOR303
PLACEBO362

ICH or Fatal Bleeding Event

Participants with ICH or fatal bleeding event (NCT03354429)
Timeframe: From randomisation (day 1) to visit 3 (day 30-34)

InterventionParticipants (Count of Participants)
TICAGRELOR22
PLACEBO6

Ischaemic Stroke

Number of participants with ischaemic stroke (NCT03354429)
Timeframe: From randomisation (day 1) to visit 3 (day 30-34)

InterventionParticipants (Count of Participants)
TICAGRELOR276
PLACEBO345

Number of Participants With Modified Rankin Scale (mRS) Score >1 at Visit 3

The modified Rankin Scale (mRS) is a scale for measuring the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability. The scale runs from 0-6, running from perfect health without symptoms to death.0 - No symptoms,1 - No significant disability. Able to carry out all usual activities, despite some symptoms. 2 - Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities. 3 - Moderate disability. Requires some help, but able to walk unassisted. 4 - Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted. 5 - Severe disability. Requires constant nursing care and attention, bedridden, incontinent. 6 - Dead. (NCT03354429)
Timeframe: Visit 3 (day 30-34)

InterventionParticipants (Count of Participants)
TICAGRELOR1282
PLACEBO1284

Premature Permanent Discontinuation of IP Due to Bleeding

Participants with premature permanent discontinuation of IP due to bleeding (NCT03354429)
Timeframe: From randomisation (day 1) to visit 3 (day 30-34)

InterventionParticipants (Count of Participants)
TICAGRELOR152
PLACEBO32

EQ-5D (EuroQol Five Dimensions Questionnaire) at End of Treatment Visit

"EQ-5D index score using the UK tariff.~EQ-5D is a self assessment of 5 dimensions: mobility, self-care, usual activities, pain and discomfort, and anxiety and depression. For each dimension responders are asked to state their status on a three level ordinal scale; whether they experience no problems (Level 1), some problems (Level 2) or severe problems (Level 3). Health states defined by the 5 dimensions can be converted into a weighted health state index (health state utility) by applying scores from the EQ-5D value sets elicited from general population samples.~The higher the index score the better the health state. In this study index scores ran from -0.59 to 1." (NCT01994720)
Timeframe: End of treatment visit (Day 90+-7d)

InterventionIndex score (Mean)
Ticagrelor 90 mg0.85
ASA 100 mg0.84

EQ-5D (EuroQol Five Dimensions Questionnaire) at Premature Treatment Discontinuation Visit

"EQ-5D index score using the UK tariff.~EQ-5D is a self assessment of 5 dimensions: mobility, self-care, usual activities, pain and discomfort, and anxiety and depression. For each dimension responders are asked to state their status on a three level ordinal scale; whether they experience no problems (Level 1), some problems (Level 2) or severe problems (Level 3). Health states defined by the 5 dimensions can be converted into a weighted health state index (health state utility) by applying scores from the EQ-5D value sets elicited from general population samples.~The higher the index score the better the health state. In this study index scores ran from -0.59 to 1." (NCT01994720)
Timeframe: Premature treatment discontinuation visit(<15 days after last dose)

InterventionIndex score (Mean)
Ticagrelor 90 mg0.72
ASA 100 mg0.68

EQ-5D at Visit 1 (Enrolment)

"EQ-5D (EuroQol five dimensions questionnaire) index score using the UK tariff.~EQ-5D is a self assessment of 5 dimensions: mobility, self-care, usual activities, pain and discomfort, and anxiety and depression. For each dimension responders are asked to state their status on a three level ordinal scale; whether they experience no problems (Level 1), some problems (Level 2) or severe problems (Level 3). Health states defined by the 5 dimensions can be converted into a weighted health state index (health state utility) by applying scores from the EQ-5D value sets elicited from general population samples.~The higher the index score the better the health state. In this study index scores ran from -0.59 to 1." (NCT01994720)
Timeframe: Visit 1 (Enrolment)

InterventionIndex score (Mean)
Ticagrelor 90 mg0.70
ASA 100 mg0.70

EQ-5D at Visit 2 (Day 7+-2d)

"EQ-5D (EuroQol five dimensions questionnaire) index score using the UK tariff.~EQ-5D is a self assessment of 5 dimensions: mobility, self-care, usual activities, pain and discomfort, and anxiety and depression. For each dimension responders are asked to state their status on a three level ordinal scale; whether they experience no problems (Level 1), some problems (Level 2) or severe problems (Level 3). Health states defined by the 5 dimensions can be converted into a weighted health state index (health state utility) by applying scores from the EQ-5D value sets elicited from general population samples.~The higher the index score the better the health state. In this study index scores ran from -0.59 to 1." (NCT01994720)
Timeframe: Visit 2 (Day 7+-2d)

InterventionIndex score (Mean)
Ticagrelor 90 mg0.80
ASA 100 mg0.79

Net Clinical Outcome

Participants with stroke, MI, death or life-threatening bleeding. If no event, censoring occures at the minimum of (last date of event assessment, end of treatment date, day 97). (NCT01994720)
Timeframe: From randomization up to 97 days

InterventionParticipants (Number)
Ticagrelor 90 mg457
ASA 100 mg508

Number of Participants by Severity of Stroke and Overall Disability

"Analysis of severity of stroke and overall disability of patients, using the modified Rankin Score, mRS.~Modified Rankin Score:~0 - No symptoms.~- No significant disability. Able to carry out all usual activities, despite some symptoms.~- Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities.~- Moderate disability. Requires some help, but able to walk unassisted.~- Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted.~- Severe disability. Requires constant nursing care and attention, bedridden, incontinent.~- Dead.~Disability defined as mRS > 1.~Odds ratio and p-value are calculated for ticagrelor versus ASA from a logistic regression model with treatment group, history of stroke and NIHSS (National Institutes of Health Stroke Scale) at baseline as explanatory variables." (NCT01994720)
Timeframe: From randomization up to 97 days

InterventionParticipants (Number)
Ticagrelor 90 mg1107
ASA 100 mg1194

Number of Participants With All-Cause Death

Participants with all-cause death. If no event, censoring at the minimum of (last date of event assessment, end of treatment date, day 97). (NCT01994720)
Timeframe: From randomization up to 97 days

InterventionParticipants (Number)
Ticagrelor 90 mg68
ASA 100 mg58

Number of Participants With Composite of Ischaemic Stroke, MI and CV Death

Participants with ischaemic stroke, MI or CV death. If no event, censoring at the minimum of (last date of event assessment, date of death from non-CV causes, end of treatment date, day 97). (NCT01994720)
Timeframe: From randomization up to 97 days

InterventionParticipants (Number)
Ticagrelor 90 mg423
ASA 100 mg475

Number of Participants With Composite of Stroke/MI/Death

Participants with stroke, MI or death. If no event, censoring occures at the minimum of (last date of event assessment, end of treatment date, day 97). (NCT01994720)
Timeframe: From randomization up to 97 days

InterventionParticipants (Number)
Ticagrelor 90 mg442
ASA 100 mg497

Number of Participants With CV Death

Participants with CV death. If no event, censoring at the minimum of (last date of event assessment, date of death from non-CV causes, end of treatment date, day 97). (NCT01994720)
Timeframe: From randomization up to 97 days

InterventionParticipants (Number)
Ticagrelor 90 mg41
ASA 100 mg35

Number of Participants With Disabling Stroke

Participants with disabling stroke. If no event, censoring at the minimum of (last date of event assessment, date of death, end of treatment date, day 97). (NCT01994720)
Timeframe: From randomization up to 97 days

InterventionParticipants (Number)
Ticagrelor 90 mg277
ASA 100 mg307

Number of Participants With Fatal Stroke

Participants with fatal stroke. If no event, censoring at the minimum of (last date of event assessment, date of death from non-CV causes, end of treatment date, day 97). (NCT01994720)
Timeframe: From randomization up to 97 days

InterventionParticipants (Number)
Ticagrelor 90 mg18
ASA 100 mg17

Number of Participants With Ischaemic Stroke

Participants with ischaemic stroke. If no event, censoring occures at the minimum of (last date of event assessment, date of death, end of treatment date, day 97). (NCT01994720)
Timeframe: From randomization up to 97 days

InterventionParticipants (Number)
Ticagrelor 90 mg385
ASA 100 mg441

Number of Participants With MI

Participants with MI. If no event, censoring at the minimum of (last date of event assessment, date of death, end of treatment date, day 97) (NCT01994720)
Timeframe: From randomization up to 97 days

InterventionParticipants (Number)
Ticagrelor 90 mg25
ASA 100 mg21

Number of Participants With PLATO Major Bleeding Event

"Participants with PLATO Major bleeding. If no event, censoring occures at the minimum of (last date of event assessment, date of death, end of treatment date, day 97).~PLATO Major bleeding is defined as a bleed that is any one of:~Fatal~Intracranial (excluding asymptomatic haemorrhagic transformations of ischemic brain infarctions and excluding micro-hemorrhages <10 mm evident only on gradient-echo MRI)~Intrapericardial bleed with cardiac tamponade~Hypovolaemic shock or severe hypotension due to bleeding and requiring pressors or surgery~Significantly disabling (eg. intraocular with permanent vision loss)~Clinically overt or apparent bleeding associated with a decrease in Hb of more than 30 g/L (1.9 mmol/L; 0.465 mmol/L)~Transfusion of 2 or more units (whole blood or packed red blood cells [PRBCs]) for bleeding." (NCT01994720)
Timeframe: From randomization up to 97 days

InterventionParticipants (Number)
Ticagrelor 90 mg31
ASA 100 mg38

Number of Participants With Premature Discontinuation of Study Drug Due to Any Bleeding Adverse Event

Participants discontinuation of study drug due to any bleeding adverse event. If no event, censoring occures at the minimum of (last date of event assessment, date of death, end of treatment date, day 97). (NCT01994720)
Timeframe: Time from first dose and up to and including 7 days following the date of last dose of the study

InterventionParticipants (Number)
Ticagrelor 90 mg82
ASA 100 mg37

Number of Participants With Stroke

Participants with stroke. If no event, censoring at the minimum of (last date of event assessment, date of death, end of treatment date, day 97) (NCT01994720)
Timeframe: From randomization up to 97 days

InterventionParticipants (Number)
Ticagrelor 90 mg390
ASA 100 mg450

Change in NIHSS

"Change from baseline to end of treatment visit in NIHSS (National Institutes of Health Stroke Scale):~0 No stroke symptoms 1-4 Minor stroke 5-15 Moderate stroke 16-20 Moderate to severe stroke 21-42 Severe stroke." (NCT01994720)
Timeframe: From randomization up to 97 days

,
InterventionParticipants (Number)
<=-5-4-3-2-1012345>5Missing
ASA 100 mg1274388101073113168379311611614450
Ticagrelor 90 mg1324037791088109968167281813610474

Any Stroke or Death Within 30 Days of Enrollment or Any Revascularization Procedure OR an Ischemic Stroke in the Territory of the Symptomatic Intracranial Artery Beyond 30 Days After Enrollment.

Any stroke (ischemic, parenchymal brain hemorrhage, subarachnoid or intraventricular hemorrhage) or death within 30 days after enrollment OR any stroke (ischemic, parenchymal brain hemorrhage, subarachnoid or intraventricular hemorrhage) or death within 30 days of any revascularization procedure of the qualifying symptomatic intracranial artery done during follow-up, OR an ischemic stroke in the territory of the symptomatic intracranial artery from day 31 after study entry to completion of follow-up. (NCT00576693)
Timeframe: Mean length of follow-up was 2.4 years

Interventionparticipants (Number)
Intensive Medical Management Plus Stenting52
Intensive Medical Management Alone34

Anti-Drug Antibodies

"Anti-drug antibodies were measured at baseline and 3 month after IMP application.~Number of patients with positive anti-drug antibodies compared to baseline are counted." (NCT01645306)
Timeframe: 3 month (+/- 1 month) after IMP application

InterventionParticipants (Count of Participants)
Placebo0
40 mg Revacept0
120 mg Revacept0

Any Clinical Event

patients with any stroke & TIA, myocardial infarction & percutaneous coronary intervention (PCI), death or bleeding within one year (365 days) after IMP application. (NCT01645306)
Timeframe: 365 days after IMP application

InterventionNumber of Events (Number)
Placebo19
40 mg Revacept15
120 mg Revacept10

Major Bleedings

patients with major bleedings occuring within 90 days after IMP application (NCT01645306)
Timeframe: 90 days after IMP application

InterventionParticipants (Count of Participants)
Placebo5
40 mg Revacept6
120 mg Revacept4

New DWI Lesion(s)

The number of new diffusion weighted imaging (DWI) lesion(s) reported. (1 day after intervention compared to baseline). (NCT01645306)
Timeframe: 1 day post intervention

InterventionNumber of new lesions (Mean)
Placebo1.2
40 mg Revacept1.0
120 mg Revacept0.6

Patients With Any Stroke or Transient Ischemic Attack (TIA)

patients with any stroke or TIA occuring within 90 days after IMP application. (NCT01645306)
Timeframe: 90 days after IMP application

InterventionParticipants (Count of Participants)
Placebo6
40 mg Revacept6
120 mg Revacept4

Participants With Adverse Events (AEs)

All adverse events were assessed during complete study period (~ 1 year after IMP application). (NCT01645306)
Timeframe: ~ 365 days after IMP application (whole study period)

,,
Interventionparticipants (Number)
patients with adverse eventspatients with drug related AEspatients with serious AEspatients with drug related serious AEspatients with AE with fatal outcome events
120 mg Revacept3221501
40 mg Revacept41101740
Placebo3541710

Reviews

45 reviews available for aspirin and Carotid Artery Narrowing

ArticleYear
Platelet Biomarkers in Patients with Atherosclerotic Extracranial Carotid Artery Stenosis: A Systematic Review.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2022, Volume: 63, Issue:3

    Topics: Aspirin; Biomarkers; Blood Platelets; Carotid Stenosis; Humans; Platelet Aggregation Inhibitors; Str

2022
Editor's Choice - Peri-Operative Outcomes of Carotid Endarterectomy are Not Improved on Dual Antiplatelet Therapy vs. Aspirin Monotherapy: A Systematic Review and Meta-Analysis.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2022, Volume: 63, Issue:4

    Topics: Aspirin; Brain Ischemia; Carotid Stenosis; Endarterectomy, Carotid; Hematoma; Hemorrhage; Hemorrhagi

2022
Pharmacological interventions for asymptomatic carotid stenosis.
    The Cochrane database of systematic reviews, 2023, 08-04, Volume: 8

    Topics: Aspirin; Atherosclerosis; Atorvastatin; Carotid Stenosis; Chlorthalidone; Fluvastatin; Hemorrhage; H

2023
Optimal Antiplatelet Therapy in Moderate to Severe Asymptomatic and Symptomatic Carotid Stenosis: A Comprehensive Review of the Literature.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2019, Volume: 57, Issue:2

    Topics: Aspirin; Asymptomatic Diseases; Carotid Stenosis; Clopidogrel; Dipyridamole; Drug Therapy, Combinati

2019
The challenge of stroke prevention with intracranial arterial stenosis.
    Current cardiology reports, 2013, Volume: 15, Issue:12

    Topics: Aspirin; Carotid Artery, Common; Carotid Stenosis; Clopidogrel; Constriction, Pathologic; Drug Thera

2013
Antiplatelet therapy to prevent recurrent stroke: Three good options.
    Cleveland Clinic journal of medicine, 2013, Volume: 80, Issue:12

    Topics: Aspirin; Carotid Stenosis; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Secon

2013
Sex differences in stroke.
    Cerebrovascular diseases (Basel, Switzerland), 2008, Volume: 26, Issue:5

    Topics: Acute Disease; Age Factors; Animals; Aspirin; Atrial Fibrillation; Carotid Stenosis; Cerebrovascular

2008
Antithrombotic therapies in cerebrovascular disease: what should we use as secondary prevention in patients with carotid artery disease?
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2009, Jul-01, Volume: 74 Suppl 1

    Topics: Anticoagulants; Aspirin; Brain Ischemia; Carotid Stenosis; Clopidogrel; Dipyridamole; Drug Therapy,

2009
Asymptomatic carotid stenosis: natural history versus therapy.
    The Israel Medical Association journal : IMAJ, 2010, Volume: 12, Issue:4

    Topics: Aspirin; Atherosclerosis; Carotid Stenosis; Endarterectomy, Carotid; Fibrinolytic Agents; Humans; St

2010
[Treatment for cervical carotid artery stenosis using evidenced-based medicine].
    Brain and nerve = Shinkei kenkyu no shinpo, 2010, Volume: 62, Issue:12

    Topics: Angioplasty; Aspirin; Carotid Stenosis; Endarterectomy, Carotid; Evidence-Based Medicine; Humans; Ra

2010
Prevention of stroke following transient ischemic attack.
    Current atherosclerosis reports, 2011, Volume: 13, Issue:4

    Topics: Anticoagulants; Antihypertensive Agents; Aspirin; Atrial Fibrillation; Brain; Carotid Stenosis; Clin

2011
[Review of major randomized clinical trials: carotid endarterectomy versus drug therapy].
    Nihon Geka Gakkai zasshi, 2011, Volume: 112, Issue:6

    Topics: Aspirin; Carotid Stenosis; Endarterectomy, Carotid; Humans; Platelet Aggregation Inhibitors; Randomi

2011
Carotid endarterectomy plus medical therapy or medical therapy alone for carotid artery stenosis in symptomatic or asymptomatic patients: a meta-analysis.
    Journal of cardiothoracic and vascular anesthesia, 2012, Volume: 26, Issue:5

    Topics: Aspirin; Asymptomatic Diseases; Carotid Stenosis; Endarterectomy, Carotid; Humans; Life Style; Rando

2012
The management of stroke patients by neurologists: common questions and new observations.
    Seminars in neurology, 2002, Volume: 22, Issue:1

    Topics: Angioplasty; Anticoagulants; Antihypertensive Agents; Aspirin; Carotid Stenosis; Case Management; Cl

2002
[Secondary prevention after ischemic stroke].
    Praxis, 2003, Jan-29, Volume: 92, Issue:5

    Topics: Administration, Oral; Angioplasty, Balloon; Anticholesteremic Agents; Anticoagulants; Aspirin; Atorv

2003
[Stenosis of the carotid arteries].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 2003, Volume: 56, Issue:5-6

    Topics: Angioplasty, Balloon; Aspirin; Brain Ischemia; Carotid Stenosis; Endarterectomy; Humans; Recurrence;

2003
[Stroke prevention].
    Therapeutische Umschau. Revue therapeutique, 2003, Volume: 60, Issue:9

    Topics: Administration, Oral; Aged; Anticoagulants; Antihypertensive Agents; Aspirin; Carotid Stenosis; Cont

2003
[Lacunar infarcts].
    Therapeutische Umschau. Revue therapeutique, 2003, Volume: 60, Issue:9

    Topics: Adult; Aged; Aspirin; Autopsy; Brain; Carotid Stenosis; Cerebral Infarction; Dementia; Female; Fibri

2003
[Carotid stenosis: diagnosis, patient selection, therapy].
    Therapeutische Umschau. Revue therapeutique, 2003, Volume: 60, Issue:9

    Topics: Aged; Aged, 80 and over; Angiography, Digital Subtraction; Angioplasty, Balloon; Aspirin; Carotid St

2003
Stroke: advances in therapy.
    The Lancet. Neurology, 2005, Volume: 4, Issue:1

    Topics: Aspirin; Carotid Stenosis; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Drug Thera

2005
Post-varicella arteriopathy of childhood: natural history of vascular stenosis.
    Neurology, 2005, Feb-22, Volume: 64, Issue:4

    Topics: Anticoagulants; Aspirin; Brain Ischemia; Carotid Artery, Internal; Carotid Stenosis; Cerebral Angiog

2005
Carotid endarterectomy--an evidence-based review: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
    Neurology, 2005, Sep-27, Volume: 65, Issue:6

    Topics: Aspirin; Carotid Stenosis; Causality; Clinical Trials as Topic; Dose-Response Relationship, Drug; En

2005
Stroke prevention in diabetes and obesity.
    Expert review of cardiovascular therapy, 2006, Volume: 4, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atrial Fibrillation; Blood Glucose; Cardiovascular

2006
Prevention of ischemic stroke: surgery.
    Current drug targets, 2007, Volume: 8, Issue:7

    Topics: Aspirin; Brain Ischemia; Carotid Artery, External; Carotid Artery, Internal; Carotid Stenosis; Coron

2007
[What should be done after the first TIA?].
    MMW Fortschritte der Medizin, 2007, May-21, Volume: 149 Suppl 2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Carotid Artery, Internal; Carotid Stenosis; Clopi

2007
Multimodality management of carotid artery stenosis: reviewing the class-I evidence.
    Journal of the National Medical Association, 2007, Volume: 99, Issue:11

    Topics: Angioplasty, Balloon; Aspirin; Carotid Stenosis; Combined Modality Therapy; Endarterectomy, Carotid;

2007
Medical compared with surgical treatment of asymptomatic carotid artery stenosis.
    Annals of internal medicine, 1995, Nov-01, Volume: 123, Issue:9

    Topics: Aspirin; Carotid Stenosis; Cerebrovascular Disorders; Combined Modality Therapy; Endarterectomy, Car

1995
[Spontaneous and heparin-induced recanalization of the completely occluded internal carotid artery--a neglected phenomenon? 2 case reports and review of the literature].
    Fortschritte der Neurologie-Psychiatrie, 1995, Volume: 63, Issue:7

    Topics: Aspirin; Carotid Artery, Internal; Carotid Stenosis; Cerebral Angiography; Combined Modality Therapy

1995
Stroke prevention.
    Archives of neurology, 1995, Volume: 52, Issue:4

    Topics: Alcohol Drinking; Aspirin; Carotid Stenosis; Cerebrovascular Disorders; Clinical Trials as Topic; Di

1995
What's new in stroke?
    Texas medicine, 1995, Volume: 91, Issue:5

    Topics: Acute Disease; Algorithms; Anticoagulants; Aspirin; Atrial Fibrillation; Carotid Stenosis; Cerebrova

1995
Guidelines for carotid endarterectomy. A multidisciplinary consensus statement from the ad hoc Committee, American Heart Association.
    Stroke, 1995, Volume: 26, Issue:1

    Topics: Aspirin; Carotid Stenosis; Cerebrovascular Disorders; Clinical Trials as Topic; Combined Modality Th

1995
Aspirin in asymptomatic carotid disease.
    Health reports, 1994, Volume: 6, Issue:1

    Topics: Aspirin; Brain Ischemia; Carotid Artery Diseases; Carotid Stenosis; Cerebrovascular Disorders; Human

1994
[Prevention of cerebrovascular insults].
    Schweizerische medizinische Wochenschrift, 1994, Nov-12, Volume: 124, Issue:45

    Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Carotid Stenosis; Cerebral Infarction; Diet; Fem

1994
[Asymptomatic carotid stenoses. Analysis of randomized studies].
    Journal des maladies vasculaires, 1993, Volume: 18, Issue:3

    Topics: Aspirin; Carotid Stenosis; Cerebrovascular Disorders; Endarterectomy, Carotid; Humans; Randomized Co

1993
Death associated with asymptomatic carotid artery stenosis: long-term clinical evaluation. VA Cooperative Study 167 Group.
    Journal of vascular surgery, 1993, Volume: 18, Issue:6

    Topics: Aged; Aspirin; Carotid Stenosis; Endarterectomy, Carotid; Follow-Up Studies; Humans; Male; Middle Ag

1993
[Carotid endarterectomy--results of current studies and their consequences].
    Medizinische Klinik (Munich, Germany : 1983), 1993, Oct-15, Volume: 88, Issue:10

    Topics: Aspirin; Carotid Stenosis; Cerebral Infarction; Clinical Trials as Topic; Endarterectomy, Carotid; H

1993
Asymptomatic carotid stenosis: surgery's the answer, but that's not the question.
    Annals of neurology, 1996, Volume: 39, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Arteriosclerosis; Aspirin; Brain Ischemia;

1996
[Treatment protocol of cerebral vascular accident].
    Revista de neurologia, 1997, Volume: 25, Issue:137

    Topics: Anticoagulants; Aspirin; Brain Ischemia; Carotid Stenosis; Clinical Protocols; Endarterectomy; Human

1997
Triflusal.
    Drugs, 1998, Volume: 55, Issue:6

    Topics: Adult; Angina Pectoris; Animals; Aspirin; Carotid Stenosis; Humans; In Vitro Techniques; Middle Aged

1998
The crucial, controversial carotid artery. Part II: Treatment.
    Harvard men's health watch, 1998, Volume: 2, Issue:12

    Topics: Arteriosclerosis; Aspirin; Carotid Stenosis; Endarterectomy, Carotid; Humans; Ischemic Attack, Trans

1998
Carotid endarterectomy.
    The Surgical clinics of North America, 1998, Volume: 78, Issue:5

    Topics: Angioplasty; Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Blood Pressure; Car

1998
Stroke: part I. A clinical update on prevention.
    American family physician, 1999, May-01, Volume: 59, Issue:9

    Topics: Aspirin; Atrial Fibrillation; Carotid Stenosis; Cerebrovascular Disorders; Clinical Trials as Topic;

1999
Indications for treatment of symptomatic atherosclerotic carotid artery disease.
    Neurosurgery clinics of North America, 2000, Volume: 11, Issue:2

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carotid Artery, Internal; Carotid Stenosis;

2000
Stroke prevention: antiplatelet and antithrombolytic therapy.
    Haemostasis, 2000, Volume: 30 Suppl 3

    Topics: Anticoagulants; Aspirin; Brain Damage, Chronic; Carotid Stenosis; Clinical Trials as Topic; Clopidog

2000
Carotid artery disease: when and how to treat?
    Acta cardiologica, 1991, Volume: 46, Issue:4

    Topics: Arteriosclerosis; Aspirin; Carotid Stenosis; Cerebrovascular Disorders; Endarterectomy, Carotid; Hum

1991

Trials

50 trials available for aspirin and Carotid Artery Narrowing

ArticleYear
Association Between Low-Dose Rivaroxaban With or Without Aspirin and Ischemic Stroke Subtypes: A Secondary Analysis of the COMPASS Trial.
    JAMA neurology, 2020, 01-01, Volume: 77, Issue:1

    Topics: Aspirin; Atherosclerosis; Atrial Fibrillation; Carotid Stenosis; Double-Blind Method; Drug Therapy,

2020
Effectiveness and safety of high dose clopidogrel plus aspirin in ischemic stroke patients with the single CYP2C19 loss-of-function allele: a randomized trial.
    BMC neurology, 2020, Oct-29, Volume: 20, Issue:1

    Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship,

2020
Carotid Stenosis and Recurrent Ischemic Stroke: A Post-Hoc Analysis of the POINT Trial.
    Stroke, 2021, Volume: 52, Issue:7

    Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Carotid Stenosis; Clopidogrel; Dual Anti-Platelet

2021
Ticagrelor Versus Aspirin in Acute Embolic Stroke of Undetermined Source.
    Stroke, 2017, Volume: 48, Issue:9

    Topics: Adenosine; Aged; Aortic Diseases; Aspirin; Atherosclerosis; Carotid Stenosis; Female; Humans; Intrac

2017
Optimal medical treatment versus carotid endarterectomy: the rationale and design of the Aggressive Medical Treatment Evaluation for Asymptomatic Carotid Artery Stenosis (AMTEC) study.
    International journal of stroke : official journal of the International Stroke Society, 2015, Volume: 10, Issue:2

    Topics: Amlodipine; Antihypertensive Agents; Aspirin; Carotid Stenosis; Combined Modality Therapy; Endartere

2015
Long-term effect of carotid surgery in asymptomatic stenosis.
    JPMA. The Journal of the Pakistan Medical Association, 2012, Volume: 62, Issue:7

    Topics: Anticoagulants; Antihypertensive Agents; Aspirin; Carotid Stenosis; Endarterectomy, Carotid; Female;

2012
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
    Lancet (London, England), 2014, Jan-25, Volume: 383, Issue:9914

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-

2014
Effect of clopidogrel with or without omeprazole in patients with carotid artery stenting.
    The West Indian medical journal, 2013, Volume: 62, Issue:2

    Topics: Angiography; Aspirin; Breath Tests; Carotid Arteries; Carotid Stenosis; Clopidogrel; Drug Interactio

2013
Influence of carotid artery stenting on cognition of elderly patients with severe stenosis of the internal carotid artery.
    Medical science monitor : international medical journal of experimental and clinical research, 2014, Aug-17, Volume: 20

    Topics: Aged; Analysis of Variance; Angioplasty; Aspirin; Atorvastatin; Carotid Stenosis; China; Clopidogrel

2014
Aterofisiol(®) in carotid plaque evolution.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Adult; Aged; Aspirin; Carotid Stenosis; Dietary Supplements; Double-Blind Method; Endarterectomy, Ca

2015
Does the Stenting Versus Aggressive Medical Therapy Trial Support Stenting for Subgroups With Intracranial Stenosis?
    Stroke, 2015, Volume: 46, Issue:11

    Topics: Angioplasty; Aspirin; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Constriction, Patholo

2015
Antiplatelet Therapy in Carotid Artery Stenting and Carotid Endarterectomy in the Asymptomatic Carotid Surgery Trial-2.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2016, Volume: 51, Issue:3

    Topics: Aspirin; Carotid Artery, Common; Carotid Stenosis; Clopidogrel; Dose-Response Relationship, Drug; En

2016
[Prevalence of acetylsalicylic acid (ASA) - low response in vascular surgery].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2016, Volume: 87, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Arterial Occlusive Diseases; Aspirin; Carotid Stenosi

2016
The curative effect comparison of two kinds of therapeutic regimens on decreasing the relative intensity of microembolic signal in CLAIR trial.
    Journal of the neurological sciences, 2016, Aug-15, Volume: 367

    Topics: Aspirin; Brain Ischemia; Carotid Stenosis; Cerebral Arterial Diseases; Clopidogrel; Drug Therapy, Co

2016
Efficacy of cilostazol-based dual antiplatelet treatment in patients undergoing carotid artery stenting.
    Neurological research, 2017, Volume: 39, Issue:8

    Topics: Aged; Aged, 80 and over; Aspirin; Carotid Stenosis; Cilostazol; Clopidogrel; Drug Therapy, Combinati

2017
Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial.
    The Lancet. Neurology, 2010, Volume: 9, Issue:5

    Topics: Adult; Aged; Aspirin; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Drug Therapy, Combina

2010
Rationale, design and population baseline characteristics of the PERFORM vascular project: an ancillary study of the Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history oF ischemic strOke o
    Cardiovascular drugs and therapy, 2010, Volume: 24, Issue:2

    Topics: Aged; Aged, 80 and over; Aspirin; Atherosclerosis; Carotid Arteries; Carotid Stenosis; Data Interpre

2010
Cilostazol reduces the progression of carotid intima-media thickness without increasing the risk of bleeding in patients with acute coronary syndrome during a 2-year follow-up.
    Heart and vessels, 2011, Volume: 26, Issue:5

    Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Analysis of Variance; Angioplasty, Balloon, Corona

2011
Anti-platelet effect of aspirin is substantially reduced after administration of heparin during carotid endarterectomy.
    Journal of vascular surgery, 2004, Volume: 40, Issue:3

    Topics: Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Carotid Stenosis; Drug Interactions; Endarterect

2004
Concurrent treatment with renin-angiotensin system blockers and acetylsalicylic acid reduces nuclear factor kappaB activation and C-reactive protein expression in human carotid artery plaques.
    Stroke, 2005, Volume: 36, Issue:1

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Aspirin; C-

2005
Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial.
    Circulation, 2005, May-03, Volume: 111, Issue:17

    Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Drug Monitoring; Drug Therapy, Combination; Embolism;

2005
Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial.
    Circulation, 2005, May-03, Volume: 111, Issue:17

    Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Drug Monitoring; Drug Therapy, Combination; Embolism;

2005
Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial.
    Circulation, 2005, May-03, Volume: 111, Issue:17

    Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Drug Monitoring; Drug Therapy, Combination; Embolism;

2005
Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial.
    Circulation, 2005, May-03, Volume: 111, Issue:17

    Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Drug Monitoring; Drug Therapy, Combination; Embolism;

2005
The benefits of combined anti-platelet treatment in carotid artery stenting.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2005, Volume: 29, Issue:5

    Topics: Aged; Aged, 80 and over; Aspirin; Carotid Stenosis; Clopidogrel; Drug Therapy, Combination; Female;

2005
[Removing phlegm and dispelling stasis method combined with Western medicine for treatment of cerebrovascular stenosis].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2008, Volume: 28, Issue:1

    Topics: Adult; Aged; Aspirin; C-Reactive Protein; Carotid Stenosis; Cerebrovascular Disorders; Clopidogrel;

2008
Lack of effect of aspirin in asymptomatic patients with carotid bruits and substantial carotid narrowing. The Asymptomatic Cervical Bruit Study Group.
    Annals of internal medicine, 1995, Nov-01, Volume: 123, Issue:9

    Topics: Aged; Aspirin; Brain Ischemia; Carotid Arteries; Carotid Stenosis; Double-Blind Method; Female; Gast

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
    JAMA, 1995, May-10, Volume: 273, Issue:18

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Stenosis; Cerebral Infarction; Endarterectomy; Female; Fo

1995
The effect of aspirin on neurodeficit and platelet aggregability in acute ischemic cerebral strokes.
    The Journal of the Association of Physicians of India, 1994, Volume: 42, Issue:6

    Topics: Adult; Aged; Aspirin; Carotid Stenosis; Cerebral Infarction; Dose-Response Relationship, Drug; Femal

1994
4. Current status of operative treatment for asymptomatic carotid stenosis.
    Canadian journal of surgery. Journal canadien de chirurgie, 1994, Volume: 37, Issue:2

    Topics: Aspirin; Carotid Stenosis; Cerebrovascular Disorders; Combined Modality Therapy; Endarterectomy, Car

1994
Cardiac prognosis of patients with carotid stenosis and no history of coronary artery disease. Veterans Affairs Cooperative Study Group 167.
    Stroke, 1994, Volume: 25, Issue:4

    Topics: Aged; Aspirin; Carotid Stenosis; Coronary Disease; Endarterectomy, Carotid; Humans; Male; Middle Age

1994
Death associated with asymptomatic carotid artery stenosis: long-term clinical evaluation. VA Cooperative Study 167 Group.
    Journal of vascular surgery, 1993, Volume: 18, Issue:6

    Topics: Aged; Aspirin; Carotid Stenosis; Endarterectomy, Carotid; Follow-Up Studies; Humans; Male; Middle Ag

1993
Can recurrent stenosis after carotid endarterectomy be prevented by low-dose acetylsalicylic acid? A double-blind, randomised and placebo-controlled study.
    European journal of vascular surgery, 1993, Volume: 7, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Carotid Artery, Internal; Carotid Stenosis; Dose-Response R

1993
Efficacy of carotid endarterectomy for asymptomatic carotid stenosis. The Veterans Affairs Cooperative Study Group.
    The New England journal of medicine, 1993, Jan-28, Volume: 328, Issue:4

    Topics: Adult; Aspirin; Blindness; Carotid Arteries; Carotid Stenosis; Cerebrovascular Disorders; Endarterec

1993
Influence of aspirin in the management of asymptomatic carotid artery stenosis. VA Cooperative Study Group on Asymptomatic Carotid Stenosis.
    Journal of vascular surgery, 1993, Volume: 17, Issue:2

    Topics: Aspirin; Carotid Artery, External; Carotid Stenosis; Cerebrovascular Disorders; Chi-Square Distribut

1993
European carotid angioplasty trial.
    Journal of endovascular surgery : the official journal of the International Society for Endovascular Surgery, 1996, Volume: 3, Issue:1

    Topics: Angioplasty, Balloon; Arterial Occlusive Diseases; Aspirin; Carotid Artery Diseases; Carotid Artery,

1996
Asymptomatic circulating cerebral emboli and cerebral blood flow velocity under aspirin and ticlopidine in patients with cerebrovascular disease.
    Neurological research, 1996, Volume: 18, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Flow Velocity; Carotid Stenosis; Cell Survival; Cereb

1996
An analysis of perioperative surgical mortality and morbidity in the asymptomatic carotid atherosclerosis study. ACAS Investigators. Asymptomatic Carotid Atherosclerosis Study.
    Stroke, 1996, Volume: 27, Issue:12

    Topics: Anesthesia; Arteriosclerosis; Aspirin; Carotid Stenosis; Cerebral Infarction; Combined Modality Ther

1996
S-nitrosoglutathione reduces the rate of embolization in humans.
    Circulation, 1998, Oct-06, Volume: 98, Issue:14

    Topics: Aged; Anticoagulants; Aspirin; Carotid Stenosis; Endarterectomy, Carotid; Female; Glutathione; Hepar

1998
Rapid decline of cerebral microemboli of arterial origin after intravenous acetylsalicylic acid.
    Stroke, 1999, Volume: 30, Issue:1

    Topics: Adult; Aged; Aspirin; Carotid Stenosis; Cerebral Arteries; Cerebrovascular Disorders; Female; Fibrin

1999
Assessment of >/=50% and <50% intracranial stenoses by transcranial color-coded duplex sonography.
    Stroke, 1999, Volume: 30, Issue:1

    Topics: Adult; Aged; Arterial Occlusive Diseases; Aspirin; Carotid Arteries; Carotid Stenosis; Cerebral Angi

1999
Current indications for carotid endarterectomy.
    Neurologia medico-chirurgica, 1998, Volume: 38 Suppl

    Topics: Aspirin; Carotid Stenosis; Endarterectomy, Carotid; Flurbiprofen; Humans; Prospective Studies; Sever

1998
Is carotid endarterectomy cost-effective in symptomatic patients with moderate (50% to 69%) stenosis?
    Journal of vascular surgery, 1999, Volume: 30, Issue:6

    Topics: Aged; Aspirin; Carotid Stenosis; Cohort Studies; Cost-Benefit Analysis; Decision Support Techniques;

1999
[What dose of acetylsalicylic acid to use after carotid endarterectomy?].
    Presse medicale (Paris, France : 1983), 2000, Mar-18, Volume: 29, Issue:10

    Topics: Aspirin; Carotid Stenosis; Endarterectomy, Carotid; Humans; Myocardial Infarction; Platelet Aggregat

2000
Effect of contralateral occlusion on long-term efficacy of endarterectomy in the asymptomatic carotid atherosclerosis study (ACAS). ACAS Investigators.
    Stroke, 2000, Volume: 31, Issue:10

    Topics: Aged; Arteriosclerosis; Aspirin; Carotid Stenosis; Disease-Free Survival; Endarterectomy, Carotid; F

2000
Acetylsalicylic acid and microembolic events detected by transcranial Doppler in symptomatic arterial stenoses.
    Cerebrovascular diseases (Basel, Switzerland), 2001, Volume: 11, Issue:4

    Topics: Aged; Aspirin; Carotid Stenosis; Cerebrovascular Circulation; Female; Humans; Intracranial Embolism

2001
Adverse effects of aspirin in the treatment of asymptomatic carotid artery stenosis. The VA Cooperative Asymptomatic Carotid Artery Stenosis Study Group.
    Journal of vascular surgery, 1992, Volume: 16, Issue:4

    Topics: Aged; Analysis of Variance; Aspirin; Carotid Stenosis; Chi-Square Distribution; Combined Modality Th

1992
Results of a randomized controlled trial of carotid endarterectomy for asymptomatic carotid stenosis. Mayo Asymptomatic Carotid Endarterectomy Study Group.
    Mayo Clinic proceedings, 1992, Volume: 67, Issue:6

    Topics: Aged; Aspirin; Carotid Stenosis; Cerebrovascular Disorders; Endarterectomy, Carotid; Female; Follow-

1992
[Dose-dependent inhibition of plaque growth in the carotid artery by acetylsalicylic acid].
    VASA. Supplementum, 1992, Volume: 35

    Topics: Angioplasty, Balloon; Aspirin; Carotid Stenosis; Dose-Response Relationship, Drug; Double-Blind Meth

1992
Failure of aspirin plus dipyridamole to prevent restenosis after carotid endarterectomy.
    Annals of internal medicine, 1992, May-01, Volume: 116, Issue:9

    Topics: Aged; Aspirin; Carotid Stenosis; Combined Modality Therapy; Dipyridamole; Drug Therapy, Combination;

1992
Asymptomatic carotid atherosclerosis study: role of the clinical coordinator.
    Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing, 1992, Volume: 10, Issue:2

    Topics: Adult; Aged; Arteriosclerosis; Aspirin; Carotid Stenosis; Cerebrovascular Disorders; Combined Modali

1992
Carotid endarterectomy.
    The New England journal of medicine, 1992, Mar-12, Volume: 326, Issue:11

    Topics: Aspirin; Carotid Stenosis; Cerebrovascular Disorders; Endarterectomy, Carotid; Humans

1992
Carotid surgery versus medical therapy in asymptomatic carotid stenosis. The CASANOVA Study Group.
    Stroke, 1991, Volume: 22, Issue:10

    Topics: Aged; Aspirin; Carotid Artery, Internal; Carotid Stenosis; Cerebral Angiography; Cerebrovascular Dis

1991

Other Studies

125 other studies available for aspirin and Carotid Artery Narrowing

ArticleYear
Efficacy and safety of perioperative dual antiplatelet therapy with ticagrelor versus clopidogrel in carotid artery stenting.
    Journal of vascular surgery, 2022, Volume: 75, Issue:4

    Topics: Aspirin; Carotid Arteries; Carotid Stenosis; Clopidogrel; Endovascular Procedures; Femoral Artery; H

2022
Dual Antiplatelet Therapy Is Associated with Increased Risk of Bleeding and Decreased Risk of Stroke Following Carotid Endarterectomy.
    Annals of vascular surgery, 2023, Volume: 88

    Topics: Aspirin; Carotid Stenosis; Coronary Artery Disease; Endarterectomy, Carotid; Humans; Platelet Aggreg

2023
Insurance status is associated with urgent carotid endarterectomy and worse postoperative outcomes.
    Journal of vascular surgery, 2023, Volume: 77, Issue:3

    Topics: Aged; Aspirin; Carotid Stenosis; Endarterectomy, Carotid; Humans; Hydroxymethylglutaryl-CoA Reductas

2023
Aspirin versus aggressive antiplatelet therapy for acute carotid stenting plus thrombectomy in tandem occlusions: ETIS Registry results.
    Journal of neurointerventional surgery, 2023, Volume: 15, Issue:e2

    Topics: Aspirin; Carotid Stenosis; Endovascular Procedures; Humans; Ischemic Stroke; Platelet Aggregation In

2023
Efficacy and safety of single versus dual antiplatelet therapy in carotid artery stenting.
    Journal of vascular surgery, 2023, Volume: 77, Issue:5

    Topics: Aspirin; Carotid Arteries; Carotid Stenosis; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Re

2023
High-on-treatment platelet reactivity predicts adverse outcome after carotid artery stenting: A prospective study.
    Thrombosis research, 2023, Volume: 222

    Topics: Aspirin; Blood Platelets; Carotid Arteries; Carotid Stenosis; Humans; Percutaneous Coronary Interven

2023
Impact of continued clopidogrel use on outcomes of patients undergoing carotid endarterectomy.
    Journal of vascular surgery, 2023, Volume: 78, Issue:2

    Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Endarterectomy, Carotid; Female; Humans; Male; Myocard

2023
Relationship between 'on-treatment platelet reactivity', shear stress, and micro-embolic signals in asymptomatic and symptomatic carotid stenosis.
    Journal of neurology, 2020, Volume: 267, Issue:1

    Topics: Aged; Aspirin; Blood Platelets; Brain Ischemia; Carotid Stenosis; Female; Humans; Intracranial Embol

2020
Dual energy CT in the management of antiplatelet therapy in patients with acute ischemic stroke for carotid obstruction.
    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2020, Volume: 26, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Carotid Stenosis; Cerebral Hemorrhage; Clopidogrel; Female;

2020
Focal Cerebral Arteriopathy in Young Adult Patients With Stroke.
    Stroke, 2020, Volume: 51, Issue:5

    Topics: Acyclovir; Adult; Antibodies, Viral; Antiviral Agents; Aspirin; Carotid Artery, Internal; Carotid St

2020
Antiplatelet Therapy During Emergent Extracranial Internal Carotid Artery Stenting: Comparison of Three Intravenous Antiplatelet Perioperative Strategies.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2021, Volume: 30, Issue:2

    Topics: Abciximab; Adenosine Monophosphate; Administration, Intravenous; Aged; Aspirin; Carotid Artery, Inte

2021
Perioperative changes of response to antiplatelet medication in vascular surgery patients.
    PloS one, 2020, Volume: 15, Issue:12

    Topics: Aged; Aged, 80 and over; Aspirin; Carotid Stenosis; Clopidogrel; Empirical Research; Female; Humans;

2020
Adjunctive treatment with low dose intra-arterial eptifibatide and intravenous aspirin during carotid stenting: A case series.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2021, Volume: 84

    Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Endovascular Procedures; Eptifibatide; Female; Humans;

2021
Clopidogrel underactivity is a common in patients with acute symptomatic severe carotid stenosis.
    Journal of the neurological sciences, 2021, 06-15, Volume: 425

    Topics: Aged; Aged, 80 and over; Aspirin; Carotid Stenosis; Clopidogrel; Female; Humans; Male; Middle Aged;

2021
Platelet Function Monitoring Performed after Carotid Stenting during Endovascular Stroke Treatment Predicts Outcome.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2021, Volume: 30, Issue:7

    Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Databases, Factual; Disability Evaluation; Drug Monito

2021
Screening for Asymptomatic Carotid Artery Stenosis: Recommendation Statement.
    American family physician, 2021, 05-15, Volume: 103, Issue:10

    Topics: Aged; Aspirin; Asymptomatic Diseases; Cardiovascular Diseases; Carotid Stenosis; Health Behavior; He

2021
Restless legs syndrome/Willis-Ekbom disease in type 2 diabetes as the initial manifestation of Parkinson's disease and major cardiovascular disease.
    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2017, Volume: 17, Issue:6

    Topics: Aged; Amines; Analgesics; Anticonvulsants; Antihypertensive Agents; Antiparkinson Agents; Aspirin; B

2017
Assessment of 'on-treatment platelet reactivity' and relationship with cerebral micro-embolic signals in asymptomatic and symptomatic carotid stenosis.
    Journal of the neurological sciences, 2017, 05-15, Volume: 376

    Topics: Aged; Aspirin; Brain; Carotid Stenosis; Case-Control Studies; Clopidogrel; Disease Progression; Fema

2017
Scoring system to predict early carotid restenosis after eversion endarterectomy by analysis of inflammatory markers.
    Journal of vascular surgery, 2018, Volume: 68, Issue:1

    Topics: Aged; Algorithms; Aspirin; Biomarkers; C-Reactive Protein; Cardiovascular Agents; Carotid Stenosis;

2018
Acute administration of tirofiban versus aspirin in emergent carotid artery stenting.
    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2019, Volume: 25, Issue:2

    Topics: Aged; Aspirin; Carotid Stenosis; Cerebral Angiography; Female; Fibrinolytic Agents; Humans; Male; Mi

2019
Critical reversible bilateral internal carotid artery stenosis associated with SLE.
    Rheumatology (Oxford, England), 2013, Volume: 52, Issue:7

    Topics: Adult; Antirheumatic Agents; Aspirin; Carotid Stenosis; Drug Therapy, Combination; Female; Glucocort

2013
Carotid artery stenting outcomes: do they correlate with antiplatelet response assays?
    Journal of neurointerventional surgery, 2014, Volume: 6, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Carotid Stenosis; Cerebral Revascularizatio

2014
Progression of asymptomatic carotid stenosis despite optimal medical therapy.
    Journal of vascular surgery, 2013, Volume: 58, Issue:1

    Topics: Aged; Aged, 80 and over; Aspirin; Asymptomatic Diseases; Biomarkers; Cardiovascular Agents; Carotid

2013
Efficacy of contemporary medical management for asymptomatic carotid artery stenosis.
    The American surgeon, 2013, Volume: 79, Issue:10

    Topics: Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors;

2013
Platelet inhibition by adjunctive cilostazol suppresses the frequency of cerebral ischemic lesions after carotid artery stenting in patients with carotid artery stenosis.
    Journal of vascular surgery, 2014, Volume: 59, Issue:3

    Topics: Aged; Angioplasty; Aspirin; Brain Ischemia; Carotid Stenosis; Cilostazol; Clopidogrel; Diffusion Mag

2014
Is carotid ultrasound necessary in the evaluation of the asymptomatic Hollenhorst plaque?
    Ophthalmology, 2013, Volume: 120, Issue:12

    Topics: Arterioles; Aspirin; Asymptomatic Diseases; Carotid Arteries; Carotid Stenosis; Endarterectomy, Caro

2013
Dual antiplatelet therapy (clopidogrel and aspirin) is associated with increased all-cause mortality after carotid revascularization for asymptomatic carotid disease.
    Journal of vascular surgery, 2014, Volume: 59, Issue:4

    Topics: Aged; Alabama; Angioplasty; Aspirin; Asymptomatic Diseases; Carotid Stenosis; Clopidogrel; Drug Ther

2014
Prospective registry of carotid artery stenting in Japan--investigation on device and antiplatelet for carotid artery stenting.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2014, Volume: 23, Issue:6

    Topics: Aged; Aged, 80 and over; Aspirin; Carotid Arteries; Carotid Stenosis; Cilostazol; Clopidogrel; Drug

2014
Regarding "Progression of asymptomatic carotid stenosis despite optimal medical therapy".
    Journal of vascular surgery, 2014, Volume: 59, Issue:6

    Topics: Aspirin; Cardiovascular Agents; Carotid Stenosis; Female; Humans; Hydroxymethylglutaryl-CoA Reductas

2014
Reply: To PMID 23806255.
    Journal of vascular surgery, 2014, Volume: 59, Issue:6

    Topics: Aspirin; Cardiovascular Agents; Carotid Stenosis; Female; Humans; Hydroxymethylglutaryl-CoA Reductas

2014
The natural history of asymptomatic severe carotid artery stenosis.
    Journal of vascular surgery, 2014, Volume: 60, Issue:5

    Topics: Aged; Aspirin; Asymptomatic Diseases; Blood Flow Velocity; Cardiovascular Agents; Carotid Stenosis;

2014
Thrombolysis May Reduce the Incidence/Extent of Postprocedural Ischemic Strokes Associated With Carotid Artery Stenting: A Hypothesis.
    Angiology, 2015, Volume: 66, Issue:7

    Topics: Aspirin; Brain Ischemia; Carotid Stenosis; Cerebral Hemorrhage; Fibrinolytic Agents; Humans; Hydroxy

2015
Evaluation of aspirin resistance and the presence of unstable carotid plaque in patients undergoing carotid endarterectomy.
    Kardiologia polska, 2015, Volume: 73, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Carotid Stenosis; Endarterectomy, Carotid;

2015
Dual Antiplatelet Therapy Prior to Expedited Carotid Surgery Reduces Recurrent Events Prior to Surgery without Significantly Increasing Peri-operative Bleeding Complications.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2015, Volume: 50, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Carotid Stenosis; Clopidogrel; Drug A

2015
Platelet reactivity and hemorrhage risk in neurointerventional procedures under dual antiplatelet therapy.
    Journal of neurointerventional surgery, 2016, Volume: 8, Issue:9

    Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Drug Therapy, Combination; Embolization, Therapeutic;

2016
Is Extended Duration of Dual Antiplatelet Therapy After Carotid Stenting Beneficial?
    Medicine, 2015, Volume: 94, Issue:40

    Topics: Aged; Aspirin; Carotid Arteries; Carotid Stenosis; Clopidogrel; Female; Follow-Up Studies; Humans; M

2015
Influence of Diabetes Mellitus and Cigarette Smoking on Variability of the Clopidogrel-Induced Antiplatelet Effect and Efficacy of Active Management of the Target P2Y12 Reaction Unit Range in Patients Undergoing Neurointerventional Procedures.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016, Volume: 25, Issue:1

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aspirin; Carotid Stenosis; Cilostazol; Clopidogrel; Dia

2016
Risk of early recurrent stroke in symptomatic carotid stenosis after best medical therapy and before endarterectomy.
    International journal of stroke : official journal of the International Stroke Society, 2016, Volume: 11, Issue:1

    Topics: Aged; Aged, 80 and over; Aspirin; Carotid Arteries; Carotid Stenosis; Clopidogrel; Endarterectomy, C

2016
Effects of Sarpogrelate Combined with Aspirin in Patients Undergoing Carotid Endarterectomy in China: A Single-Center Retrospective Study.
    Annals of vascular surgery, 2016, Volume: 35

    Topics: Aged; Aspirin; Blood Loss, Surgical; Carotid Stenosis; China; Clopidogrel; Drug Therapy, Combination

2016
Dual Antiplatelet Therapy Does Not Increase the Risk of Bleeding After Carotid Endarterectomy: Results of a Prospective Study.
    Annals of vascular surgery, 2017, Volume: 40

    Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Asymptomatic Diseases; Carotid Stenosis; Clopidogr

2017
Combined carotid stenting and urgent coronary artery surgery in unstable angina patients with severe carotid stenosis.
    Interactive cardiovascular and thoracic surgery, 2009, Volume: 9, Issue:2

    Topics: Aged; Aged, 80 and over; Angina, Unstable; Angioplasty, Balloon; Anticoagulants; Aspirin; Carotid St

2009
Retinal artery embolization during carotid angioplasty and carotid artery stenting: case report.
    Neurologia medico-chirurgica, 2009, Volume: 49, Issue:5

    Topics: Aged; Angioplasty, Balloon; Anticoagulants; Antipyrine; Aspirin; Carotid Artery, External; Carotid S

2009
[Diagnostics and treatment of carotidynia--rare angiological disease].
    Zentralblatt fur Chirurgie, 2009, Volume: 134, Issue:4

    Topics: Angiography; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carotid Artery Diseases; Carotid Arte

2009
Redo surgery or carotid stenting for restenosis after carotid endarterectomy: results of two different treatment strategies.
    Annals of vascular surgery, 2010, Volume: 24, Issue:2

    Topics: Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Endarterectomy, Carotid; Feasibilit

2010
[Beyond coronary artery disease: interventional approach to carotid occlusive disease].
    Giornale italiano di cardiologia (2006), 2010, Volume: 11, Issue:10 Suppl 1

    Topics: Aged; Aged, 80 and over; Angioplasty; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carotid Arte

2010
Recurrent ischemic stroke in a patient with ulcerative colitis and high levels of lipoprotein (a).
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2011, Volume: 22, Issue:6

    Topics: Anticholesteremic Agents; Anticoagulants; Aspirin; Atorvastatin; Blood Coagulation Tests; Carotid St

2011
Have medical therapy and stenting been fairly compared? A repercussion upon termination of recruitment in the SAMMPRIS trial.
    International journal of stroke : official journal of the International Stroke Society, 2011, Volume: 6, Issue:4

    Topics: Angioplasty; Aspirin; Carotid Stenosis; Clinical Trials as Topic; Clopidogrel; Humans; National Inst

2011
Microembolic signals and aspirin resistance in patients with carotid stenosis.
    Cardiovascular therapeutics, 2012, Volume: 30, Issue:4

    Topics: Aged; Aged, 80 and over; Aspirin; Carotid Artery, Internal; Carotid Stenosis; Drug Monitoring; Drug

2012
Body weight: a risk factor for subtherapeutic antithrombotic therapy in neurovascular stenting.
    Journal of neurointerventional surgery, 2011, Volume: 3, Issue:2

    Topics: Aspirin; Body Mass Index; Body Weight; Carotid Stenosis; Cerebrovascular Disorders; Clopidogrel; Fem

2011
Blind runner.
    Survey of ophthalmology, 2012, Volume: 57, Issue:5

    Topics: Adult; Angiogenesis Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Hum

2012
Editorial - do not throw the baby out with the bathwater….
    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2011, Volume: 17, Issue:4

    Topics: Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Humans; Multicenter Studies as Topic; National

2011
Transient ischemic attacks in a 22-year-old.
    The American journal of medicine, 2012, Volume: 125, Issue:2

    Topics: Anticoagulants; Aspirin; Carotid Stenosis; Diagnosis, Differential; Female; Glucocorticoids; Heparin

2012
Perioperative use of aspirin for patients undergoing carotid endarterectomy.
    VASA. Zeitschrift fur Gefasskrankheiten, 2012, Volume: 41, Issue:4

    Topics: Administration, Oral; Aged; Aspirin; Carotid Artery, Internal; Carotid Stenosis; Drug Administration

2012
Symptomatic patients with intraluminal carotid artery thrombus: outcome with a strategy of initial anticoagulation.
    Journal of neurosurgery, 2013, Volume: 118, Issue:1

    Topics: Adult; Aged; Anticoagulants; Aspirin; Brain Ischemia; Carotid Arteries; Carotid Artery Thrombosis; C

2013
Continued concern about parent vessel steno-occlusive progression with Onyx HD-500 and the utility of quantitative magnetic resonance imaging in serial assessment.
    Neurosurgery, 2013, Volume: 72, Issue:3

    Topics: Angioplasty; Aspirin; Carotid Artery Diseases; Carotid Stenosis; Clopidogrel; Constriction, Patholog

2013
Asymptomatic carotid stenosis.
    Circulation, 2013, Feb-12, Volume: 127, Issue:6

    Topics: Aged; Amlodipine; Anticholesteremic Agents; Aspirin; Asymptomatic Diseases; Atorvastatin; Azetidines

2013
[Transient cerebral ischemia--precursors of stroke. Can warning signs be recognized?].
    MMW Fortschritte der Medizin, 2003, Feb-13, Volume: 145, Issue:7

    Topics: Aspirin; Brain; Carotid Stenosis; Cerebral Infarction; Diagnostic Imaging; Exercise; Humans; Ischemi

2003
[Stroke is not equal to stroke. Keep track of the causes].
    MMW Fortschritte der Medizin, 2003, Volume: 145 Suppl 1

    Topics: Adult; Antihypertensive Agents; Aspirin; Carotid Artery, Common; Carotid Artery, External; Carotid S

2003
[Primary prevention of stroke. What helps--what does not help? The guidelines of the German Society of Neurology briefly summarized].
    MMW Fortschritte der Medizin, 2003, Volume: 145 Suppl 1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Alcohol Drinking; Anticholesteremic

2003
[Outpatient primary stent-angioplasty in symptomatic internal carotid artery stenoses].
    Zentralblatt fur Chirurgie, 2003, Volume: 128, Issue:9

    Topics: Aged; Angiography; Angioplasty, Balloon; Anticoagulants; Aspirin; Carotid Artery, Internal; Carotid

2003
Stent-coil treatment of a distal internal carotid artery dissecting pseudoaneurysm on a redundant loop by use of a flexible, dedicated nitinol intracranial stent.
    AJNR. American journal of neuroradiology, 2004, Volume: 25, Issue:2

    Topics: Adult; Alloys; Aneurysm, False; Aspirin; Carotid Artery, Internal, Dissection; Carotid Stenosis; Com

2004
Is the endovascular treatment of carotid stenosis in high-risk patients really safer than carotid endarterectomy?
    Cerebrovascular diseases (Basel, Switzerland), 2004, Volume: 17, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon; Aspirin; Carotid Stenosis; Endarterectomy, Car

2004
The Willis Lecture 2003: evaluating treatments for stroke patients too slowly: time to get out of second gear.
    Stroke, 2004, Volume: 35, Issue:9

    Topics: Angioplasty; Anticoagulants; Antihypertensive Agents; Aspirin; Carotid Stenosis; Clinical Trials as

2004
[Carotid endarterectomy indicated in asymptomatic stenosis].
    Nederlands tijdschrift voor geneeskunde, 2004, Dec-11, Volume: 148, Issue:50

    Topics: Aspirin; Carotid Artery, Internal; Carotid Stenosis; Endarterectomy, Carotid; Humans; Risk Factors;

2004
Neurological outcome of conservative versus endovascular treatment of patients with asymptomatic high-grade carotid artery stenosis: a propensity score-adjusted analysis.
    Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 2005, Volume: 12, Issue:2

    Topics: Aged; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Disease-Free Survival; Female; Follow-Up

2005
[Strokes associated with cervical artery dissection, and systemic mastocytosis: an unfortuitous association? A report of two cases].
    La Revue de medecine interne, 2005, Volume: 26, Issue:10

    Topics: Aspirin; Brain Infarction; Carotid Artery, Internal, Dissection; Carotid Stenosis; Clopidogrel; Fibr

2005
Increased platelet count and leucocyte-platelet complex formation in acute symptomatic compared with asymptomatic severe carotid stenosis.
    Journal of neurology, neurosurgery, and psychiatry, 2005, Volume: 76, Issue:9

    Topics: Acute Disease; Aged; Aspirin; Carotid Stenosis; Female; Fibrinolytic Agents; Flow Cytometry; Humans;

2005
[Prophylaxis of stroke].
    Praxis, 2005, Jul-27, Volume: 94, Issue:30-31

    Topics: Age Factors; Aged; Angioplasty, Balloon; Anticoagulants; Antihypertensive Agents; Aspirin; Atrial Fi

2005
Feasibility trial of carotid stenting with and without an embolus protection device.
    Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 2005, Volume: 12, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Vessel Prosthesis Implantation; Carotid Artery, Commo

2005
Procedure-related complications and early neurological adverse events of unprotected and protected carotid stenting: temporal trends in a consecutive patient series.
    Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 2005, Volume: 12, Issue:5

    Topics: Aged; Aspirin; Blood Vessel Prosthesis Implantation; Carotid Artery, Internal; Carotid Stenosis; Clo

2005
Letter regarding article by Markus et al, "Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic cardiac stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid
    Circulation, 2005, Nov-15, Volume: 112, Issue:20

    Topics: Aspirin; Carotid Stenosis; Clopidogrel; Drug Therapy, Combination; Embolism; Humans; Platelet Aggreg

2005
Letter regarding article by Markus et al, "Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic cardiac stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid
    Circulation, 2005, Nov-15, Volume: 112, Issue:20

    Topics: Aspirin; Carotid Stenosis; Clopidogrel; Drug Therapy, Combination; Embolism; Humans; Platelet Aggreg

2005
Imaging of a regressive coronary soft plaque under lipid lowering therapy by multi-slice computed tomography.
    The international journal of cardiovascular imaging, 2006, Volume: 22, Issue:1

    Topics: Aspirin; Atorvastatin; Carotid Stenosis; Coronary Artery Disease; Drug Therapy, Combination; Heptano

2006
The use of embolic signal detection in multicenter trials to evaluate antiplatelet efficacy: signal analysis and quality control mechanisms in the CARESS (Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic carotid Stenosis) trial.
    Stroke, 2006, Volume: 37, Issue:4

    Topics: Aspirin; Carotid Stenosis; Clopidogrel; Humans; Intracranial Embolism; Multicenter Studies as Topic;

2006
[A case of carotid stenting via the transbrachial approach in the bovine arch].
    No shinkei geka. Neurological surgery, 2006, Volume: 34, Issue:3

    Topics: Aged; Aspirin; Brachial Artery; Carotid Artery, Common; Carotid Artery, Internal; Carotid Stenosis;

2006
Compatibility of carotid stenting and cardiac surgery.
    Stroke, 2006, Volume: 37, Issue:5

    Topics: Aspirin; Blood Loss, Surgical; Carotid Arteries; Carotid Stenosis; Humans; Platelet Aggregation Inhi

2006
Absence epilepsy associated with moyamoya disease. Case report.
    Journal of neurosurgery, 2006, Volume: 104, Issue:4 Suppl

    Topics: Anticonvulsants; Aspirin; Carotid Artery, Internal; Carotid Stenosis; Cerebral Angiography; Cerebral

2006
Late in-stent thrombosis following carotid angioplasty and stenting.
    Neurology, 2006, May-23, Volume: 66, Issue:10

    Topics: Aged; Aged, 80 and over; Angiography, Digital Subtraction; Angioplasty, Balloon; Anticoagulants; Aph

2006
Antiplatelet therapy prior to carotid endarterectomy--still room for improvement.
    VASA. Zeitschrift fur Gefasskrankheiten, 2006, Volume: 35, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Austria; Carotid Artery, Internal; Carotid Stenosis; Clopid

2006
Carotid stenting.
    Circulation, 2006, Jul-04, Volume: 114, Issue:1

    Topics: Aged; Aspirin; Cardiovascular Agents; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Endar

2006
The significance of incomplete stent apposition in patients undergoing stenting of internal carotid artery stenosis.
    AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:7

    Topics: Aged; Aged, 80 and over; Angioplasty, Balloon; Aspirin; Brain Ischemia; Carotid Arteries; Carotid St

2006
Point of care testing of aspirin resistance in patients with vascular disease.
    ANZ journal of surgery, 2006, Volume: 76, Issue:10

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carotid Artery, Internal;

2006
[Guidelines given by the DSG and DGN concerning stroke therapy--new therapeutic aspects].
    Clinical research in cardiology : official journal of the German Cardiac Society, 2006, Volume: 95 Suppl 6

    Topics: Aged; Antihypertensive Agents; Aspirin; Carotid Stenosis; Cerebral Infarction; Combined Modality The

2006
Endarterectomy for carotid artery stenosis: who qualifies?
    The Journal of family practice, 2006, Volume: 55, Issue:10

    Topics: Aspirin; Carotid Stenosis; Endarterectomy, Carotid; Humans; Patient Selection; Platelet Aggregation

2006
Swine model of carotid artery atherosclerosis: experimental induction by surgical partial ligation and dietary hypercholesterolemia.
    AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:9

    Topics: Angiography; Angioplasty, Balloon; Animals; Aspirin; Calcinosis; Carotid Arteries; Carotid Artery In

2006
Role of antiplatelets in carotid artery stenting.
    Stroke, 2007, Volume: 38, Issue:1

    Topics: Angioplasty, Balloon; Aspirin; Carotid Stenosis; Clinical Trials as Topic; Clopidogrel; Dipyridamole

2007
Cessation of microemboli in the middle cerebral artery after a single dose of aspirin in a young patient with emboliogenic lacunar syndrome of carotid origin.
    The Israel Medical Association journal : IMAJ, 2006, Volume: 8, Issue:10

    Topics: Adult; Anemia, Iron-Deficiency; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain; Brain Infar

2006
The frequency of aspirin resistance and its risk factors in patients with metabolic syndrome.
    International journal of cardiology, 2007, Feb-14, Volume: 115, Issue:3

    Topics: Adult; Aged; Aspirin; Cardiovascular Diseases; Carotid Stenosis; Cross-Sectional Studies; Dose-Respo

2007
Late in-stent thrombosis following carotid angioplasty and stenting.
    Neurology, 2007, Jan-30, Volume: 68, Issue:5

    Topics: Aged; Aged, 80 and over; Angiography, Digital Subtraction; Angioplasty, Balloon; Anticoagulants; Aph

2007
Internal carotid artery stenosis with ipsilateral persistent hypoglossal artery presenting as a multiterritorial embolic infarction: a case report.
    Acta radiologica (Stockholm, Sweden : 1987), 2007, Volume: 48, Issue:1

    Topics: Aged; Aspirin; Basilar Artery; Brain; Carotid Artery, Internal; Carotid Stenosis; Cerebral Infarctio

2007
Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques.
    Thrombosis and haemostasis, 2007, Volume: 97, Issue:3

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Antibodies, Monoclonal; Aspirin; Atherosclerosis; Bl

2007
Amaurosis fugax caused by retinal artery vasospasm. Case illustration.
    Journal of neurosurgery, 2007, Volume: 106, Issue:5

    Topics: Adult; Amaurosis Fugax; Aspirin; Calcium Channel Blockers; Carotid Artery, Internal; Carotid Stenosi

2007
Aspirin resistance among long-term aspirin users after carotid endarterectomy and controls: flow cytometric measurement of aspirin-induced platelet inhibition.
    Journal of vascular surgery, 2007, Volume: 45, Issue:6

    Topics: Aged; Arachidonic Acid; Aspirin; Blood Platelets; Carotid Stenosis; Case-Control Studies; Cyclooxyge

2007
Prediction and prevention of stroke in patients with symptomatic carotid stenosis: the high-risk period and the high-risk patient.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2008, Volume: 35, Issue:3

    Topics: Aspirin; Carotid Stenosis; Clopidogrel; Endarterectomy, Carotid; Humans; Ischemic Attack, Transient;

2008
Consensus document on intermittent claudication from the Central European Vascular Forum 1st edition - Abano Terme (Italy) - May 2005 2nd revision - Portroz (Slovenia) September 2007.
    International angiology : a journal of the International Union of Angiology, 2008, Volume: 27, Issue:2

    Topics: Aspirin; Carotid Stenosis; Clopidogrel; Disease Progression; Exercise Test; Humans; Intermittent Cla

2008
Operative indication in asymptomatic carotid arterial disease.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 1995, Volume: 10, Issue:4

    Topics: Arteriosclerosis; Aspirin; Carotid Stenosis; Cerebrovascular Disorders; Endarterectomy, Carotid; Gui

1995
Can overall results of clinical trials be applied to all patients?
    Lancet (London, England), 1995, Jun-24, Volume: 345, Issue:8965

    Topics: Aspirin; Carotid Stenosis; Cerebrovascular Disorders; Clinical Trials as Topic; Endarterectomy, Caro

1995
Effect of Y-20811, a thromboxane synthetase inhibitor, on photochemically induced cerebral embolism in rabbits.
    Thrombosis research, 1993, May-01, Volume: 70, Issue:3

    Topics: Animals; Aspirin; Carotid Artery Thrombosis; Carotid Stenosis; Cerebral Infarction; Disease Models,

1993
Anticoagulants, antiaggregants or nothing following carotid endarterectomy?
    European journal of vascular surgery, 1993, Volume: 7, Issue:4

    Topics: Aged; Aspirin; Carotid Stenosis; Cause of Death; Endarterectomy, Carotid; Female; Follow-Up Studies;

1993
[Prevention of stroke. Blood pressure lowering changes in life style and diet are highly effective].
    Lakartidningen, 1993, Aug-11, Volume: 90, Issue:32-33

    Topics: Anticoagulants; Aspirin; Carotid Stenosis; Cerebrovascular Disorders; Endarterectomy, Carotid; Feedi

1993
A personal view: the Asymptomatic Carotid Atherosclerosis Study results--read the label carefully.
    Journal of vascular surgery, 1996, Volume: 23, Issue:1

    Topics: Arteriosclerosis; Aspirin; Canada; Carotid Stenosis; Cerebrovascular Disorders; Endarterectomy, Caro

1996
Aspirin for asymptomatic carotid artery stenosis.
    Annals of internal medicine, 1996, Sep-01, Volume: 125, Issue:5

    Topics: Aspirin; Carotid Stenosis; Confidence Intervals; Humans

1996
Aspirin for asymptomatic carotid artery stenosis.
    Annals of internal medicine, 1996, Sep-01, Volume: 125, Issue:5

    Topics: Aspirin; Carotid Stenosis; Female; Humans; Male; Myocardial Infarction

1996
Aspirin for asymptomatic carotid artery stenosis.
    Annals of internal medicine, 1996, Sep-01, Volume: 125, Issue:5

    Topics: Aspirin; Carotid Stenosis; Humans; Myocardial Infarction

1996
US National Survey of Physician Practices for the Secondary and Tertiary Prevention of Ischemic Stroke. Medical therapy in patients with carotid artery stenosis.
    Stroke, 1996, Volume: 27, Issue:9

    Topics: Anticoagulants; Aspirin; Brain Ischemia; Carotid Stenosis; Cerebrovascular Disorders; Data Collectio

1996
Stenting in the carotid artery: initial experience in 110 patients.
    Journal of endovascular surgery : the official journal of the International Society for Endovascular Surgery, 1996, Volume: 3, Issue:1

    Topics: Aged; Aged, 80 and over; Angioplasty, Balloon; Arterial Occlusive Diseases; Aspirin; Carotid Artery

1996
[Atrial fibrillation, carotid stenosis and stroke].
    Revista de neurologia, 1996, Volume: 24, Issue:125

    Topics: Aspirin; Atrial Fibrillation; Brain; Carotid Stenosis; Cerebrovascular Disorders; Cyclooxygenase Inh

1996
Considerations in the prophylactic treatment of transient ischemic attack or ischemic stroke in the carotid artery territory.
    Schweizer Archiv fur Neurologie und Psychiatrie (Zurich, Switzerland : 1985), 1995, Volume: 146, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Carotid Stenosis; Cerebrovascular Disorders

1995
Differential involvement of serotonin 2A/C and thromboxane A2/prostanoid receptors in high- vs. low-shear rate arterial thrombosis in rabbits.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2

    Topics: Animals; Arteriovenous Shunt, Surgical; Aspirin; Blood Pressure; Bridged Bicyclo Compounds, Heterocy

1997
A late complication of internal carotid artery stenting.
    Journal of vascular surgery, 1998, Volume: 27, Issue:4

    Topics: Angioplasty; Anticoagulants; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Carotid Ste

1998
Outcome in patients with symptomatic occlusion of the internal carotid artery.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2000, Volume: 19, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Carotid Artery, Internal; Carotid Stenosis;

2000
Endogenous tissue factor pathway inhibitor modulates thrombus formation in an in vivo model of rabbit carotid artery stenosis and endothelial injury.
    Circulation, 2000, Jul-04, Volume: 102, Issue:1

    Topics: Animals; Antibodies; Aspirin; Blood Coagulation; Blood Flow Velocity; Carotid Artery Injuries; Carot

2000
Does carotid endarterectomy benefit patients with carotid stenosis but no symptoms?
    The Journal of family practice, 2000, Volume: 49, Issue:7

    Topics: Aged; Aspirin; Carotid Stenosis; Endarterectomy, Carotid; Female; Fibrinolytic Agents; Follow-Up Stu

2000
Antiplatelet drugs in cardiovascular prevention: coronary events and stroke: primary prevention.
    Prescrire international, 2000, Volume: 9, Issue:47

    Topics: Aspirin; Carotid Stenosis; Cost-Benefit Analysis; Diabetes Mellitus; Digestive System; Female; Human

2000
Systemic lupus erythematosus associated with moyamoya syndrome.
    Lupus, 2000, Volume: 9, Issue:8

    Topics: Adolescent; Anticoagulants; Aspirin; Brain; Brain Ischemia; Carotid Artery, Internal; Carotid Stenos

2000
Clinical application of procedural platelet monitoring during percutaneous coronary intervention among patients at increased bleeding risk.
    Journal of thrombosis and thrombolysis, 2001, Volume: 11, Issue:2

    Topics: Abciximab; Adult; Aged; Aged, 80 and over; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibod

2001
[Arterial hypertension - the specific case].
    Deutsche medizinische Wochenschrift (1946), 2001, Nov-02, Volume: 126, Issue:44

    Topics: Aspirin; Carotid Artery, Internal; Carotid Stenosis; Diabetes Complications; Diet; Exercise; Follow-

2001
Dual antiplatelet therapy with clopidogrel and aspirin after carotid artery stenting.
    The Journal of invasive cardiology, 2001, Volume: 13, Issue:12

    Topics: Aged; Aged, 80 and over; Aspirin; Carotid Stenosis; Clopidogrel; Combined Modality Therapy; Female;

2001
Macrophages are associated with lipid-rich carotid artery plaques, echolucency on B-mode imaging, and elevated plasma lipid levels.
    Journal of vascular surgery, 2002, Volume: 35, Issue:1

    Topics: Analysis of Variance; Aspirin; Carotid Arteries; Carotid Artery Diseases; Carotid Stenosis; Endarter

2002
Thrombostatin, a bradykinin metabolite, reduces platelet activation in a model of arterial wall injury.
    Cardiovascular research, 2002, Volume: 53, Issue:4

    Topics: Animals; Aspirin; Blood Platelets; Bradykinin; Carotid Arteries; Carotid Artery Injuries; Carotid St

2002
Report of dissection of the internal carotid artery in three cases.
    Neurosurgical review, 1992, Volume: 15, Issue:1

    Topics: Angiography, Digital Subtraction; Aortic Dissection; Aspirin; Carotid Artery Diseases; Carotid Arter

1992
Antithrombotic effects of a platelet fibrinogen receptor antagonist in a canine model of carotid artery thrombosis.
    Stroke, 1992, Volume: 23, Issue:5

    Topics: Animals; Aspirin; Blood Platelets; Carotid Artery Thrombosis; Carotid Stenosis; Cerebrovascular Circ

1992
Experimental carotid stenosis and endothelial injury in the rabbit: an in vivo model to study intravascular platelet aggregation.
    Thrombosis and haemostasis, 1992, Mar-02, Volume: 67, Issue:3

    Topics: Animals; Arachidonic Acid; Aspirin; Carotid Stenosis; Disease Models, Animal; Endothelium, Vascular;

1992
[30 mg acetylsalicylic acid per day is equally effective as 238 mg in patients following a transient ischemic attack or a non-invalidating brain infarct, and with fewer side effects].
    Nederlands tijdschrift voor geneeskunde, 1992, Feb-01, Volume: 136, Issue:5

    Topics: Aspirin; Carotid Stenosis; Endarterectomy; Humans; Reperfusion

1992
[Treatment of acute manifestation of hemichorea with aspirin. A case report].
    Acta medica Austriaca, 1991, Volume: 18, Issue:4

    Topics: Aged; Aged, 80 and over; Anesthesia, General; Aspirin; Brain Ischemia; Carotid Stenosis; Chorea; Cor

1991