Page last updated: 2024-10-22

aspirin and Carotid Artery Diseases

aspirin has been researched along with Carotid Artery Diseases in 158 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Carotid Artery Diseases: Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.

Research Excerpts

ExcerptRelevanceReference
"In order to evaluate the effect of triflusal (2-acetyloxy-4-trifluoromethyl benzoic acid), an orally active antiplatelet agent, on arteriosclerosis progression, a pilot, parallel, double-dummy, double-blind clinical trial vs acetylsalicylic acid (ASA) was carried out in patients with subclinical atherosclerotic lesions."9.09Effects of triflusal on arteriosclerosis progression assessed with high-resolution arterial ultrasound. ( Ambrosoli, L; Belcaro, G; Cesarone, MR; DeSanctis, MT; Fugazza, L; Girardello, R; Incandela, L; Laurora, G; Peracino, L; Poli, A, 1999)
"PubMed and MEDLINE searches (up to January 2010) were performed to identify primary literature, using search terms including aspirin, stroke prevention, acute ischemic stroke, acetylsalicylic acid, atrial fibrillation, myocardial infarction, and carotid endarterectomy."8.86Aspirin dosing for the prevention and treatment of ischemic stroke: an indication-specific review of the literature. ( Ansara, AJ; Arif, SA; Koehler, JM; Nisly, SA; Nordmeyer, ST, 2010)
"End-pouch ECA aneurysms were created in adult rats and were then embedded with either platinum or HydroCoils."7.83Aspirin and Clopidogrel Inhibit Aneurysm Healing after HydroCoil Implantation in External Carotid Artery Aneurysm Model. ( Chaudhary, N; Gemmete, JJ; Li, P; Pandey, AS; Thompson, BG; Xi, G; Zhang, C, 2016)
"Further to characterize the processes involved in the FeCl3-induced thrombosis model, we determined the effect of aspirin, heparin, hirudin, trans-4-(aminomethyl) cyclohexane carboxylic acid (AMCHA), thrombocytopenia, and flow modifications on time to occlusion (TTO) and thrombus weight (TW) in the rat carotid artery."7.70Demonstration of flow and platelet dependency in a ferric chloride-induced model of thrombosis. ( Kambayashi, J; Lockyer, S, 1999)
"Thromboxane A2 (TXA2) biosynthesis was studied in healthy subjects, patients with chronic cerebral infarction, patients under chronic aspirin treatment and patients with atrial fibrillation."7.68Urinary 11-dehydro-thromboxane B2: a quantitative index of platelet activation in cerebral infarction. ( Hayashi, Y; Nakahama, H; Nakanishi, T; Shimizu, S; Sugita, M; Takiguchi, A; Uyama, O; Yamamoto, S, 1992)
"Methods- Carotid atherosclerosis was analyzed either as the presence of mild (ie, 20%-49%) atherosclerotic stenosis or, separately, as the presence of carotid plaque."6.90Efficacy and Safety of Rivaroxaban Versus Aspirin in Embolic Stroke of Undetermined Source and Carotid Atherosclerosis. ( Amarenco, P; Berkowitz, SD; Bornstein, N; Camps-Renom, P; Connolly, SJ; Cucchiara, B; Gagliardi, RJ; Hart, RG; Korompoki, E; Lang, W; Lavados, P; Makaritsis, K; Marti-Fabregas, J; Meseguer, E; Milionis, H; Mundl, H; Ntaios, G; Papavasileiou, V; Siegler, JE; Swaminathan, B; Vemmos, K, 2019)
"We performed an exploratory analysis of the interaction of the treatment effects of aspirin plus clopidogrel versus aspirin monotherapy, stratified by presence of ipsilateral nonstenotic carotid disease in patients with minor ischemic stroke in the POINT trial."5.34Ipsilateral Nonstenotic Carotid Disease in Minor Ischemic Stroke: an Exploratory Analysis of The POINT Randomized Clinical Trial. ( Brorson, JR; Bulwa, Z; Pinto, CB; Saleh Velez, FG, 2020)
" The combination of rivaroxaban plus aspirin compared with aspirin alone reduced the composite endpoint of cardiovascular death, myocardial infarction, or stroke (126 [5%] of 2492 vs 174 [7%] of 2504; hazard ratio [HR] 0·72, 95% CI 0·57-0·90, p=0·0047), and major adverse limb events including major amputation (32 [1%] vs 60 [2%]; HR 0·54 95% CI 0·35-0·82, p=0·0037)."5.27Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial. ( Aboyans, V; Alings, M; Anand, SS; Avezum, AA; Bangdiwala, SI; Bhatt, DL; Bosch, J; Branch, K; Chen, E; Commerford, PJ; Connolly, SJ; Diaz, R; Eikelboom, JW; Fox, KAA; Hart, RG; Kakkar, AK; Keltai, K; Leong, DP; Lewis, BS; Lopez-Jaramillo, P; Maggioni, AP; Misselwitz, F; O'Donnell, M; Pogosova, N; Ryden, L; Störk, S; Vanassche, T; Varigos, JD; Vinereanu, D; Widimsky, P; Yusuf, S; Zhu, J, 2018)
"In order to evaluate the effect of triflusal (2-acetyloxy-4-trifluoromethyl benzoic acid), an orally active antiplatelet agent, on arteriosclerosis progression, a pilot, parallel, double-dummy, double-blind clinical trial vs acetylsalicylic acid (ASA) was carried out in patients with subclinical atherosclerotic lesions."5.09Effects of triflusal on arteriosclerosis progression assessed with high-resolution arterial ultrasound. ( Ambrosoli, L; Belcaro, G; Cesarone, MR; DeSanctis, MT; Fugazza, L; Girardello, R; Incandela, L; Laurora, G; Peracino, L; Poli, A, 1999)
"We compared the outcomes of 2,500 patients who suffered from previous cerebrovascular disorders (transient ischemic attacks, reversible ischemic neurologic deficits, or completed strokes) treated with acetylsalicylic acid plus dipyridamole or matched placebo and followed for 2 years."5.06European Stroke Prevention Study. ESPS Group. ( , 1990)
" The 2017 European Society of Cardiology (ESC)/European Society for Vascular Surgery (ESVS) guidelines recommend for patients with asymptomatic CAAD ≥60% the use of aspirin 75 to 100 mg once daily or clopidogrel 75 mg once daily at the exception of patient at very high bleeding risk."5.01Management of Patients with Asymptomatic and Symptomatic Carotid Artery Disease: Update on Anti-Thrombotic Therapy. ( Aboyans, V; Anand, SS; Bauersachs, R; Bosch, J; Debus, ES; Eikelboom, JW; Mazzolai, L; Nehler, M; Nikol, S; Pastori, D; Patel, MR; Ricco, JB; Tanguay, JF; Verhamme, P; Violi, F, 2019)
" Three preventive strategies were identified: (i) intra-operative transcranial Doppler (TCD) ultrasound and completion angioscopy which virtually abolished intra-operative stroke, primarily through the removal of residual luminal thrombus prior to restoration of flow; (ii) dual antiplatelet therapy with a single 75-mg dose of clopidogrel the night before surgery in addition to regular 75 mg aspirin which virtually abolished post-operative thromboembolic stroke and may also have contributed towards a decline in stroke/death following major cardiac events; and (iii) the provision of written guidance for managing post-CEA hypertension which was associated with virtual abolition of intracranial haemorrhage and stroke as a result of hyperperfusion syndrome."4.89Closing the loop: a 21-year audit of strategies for preventing stroke and death following carotid endarterectomy. ( Bell, PR; Bown, MJ; Dennis, MJ; London, NJ; McCarthy, MJ; Nasim, A; Naylor, AR; Sayers, RD, 2013)
"PubMed and MEDLINE searches (up to January 2010) were performed to identify primary literature, using search terms including aspirin, stroke prevention, acute ischemic stroke, acetylsalicylic acid, atrial fibrillation, myocardial infarction, and carotid endarterectomy."4.86Aspirin dosing for the prevention and treatment of ischemic stroke: an indication-specific review of the literature. ( Ansara, AJ; Arif, SA; Koehler, JM; Nisly, SA; Nordmeyer, ST, 2010)
"End-pouch ECA aneurysms were created in adult rats and were then embedded with either platinum or HydroCoils."3.83Aspirin and Clopidogrel Inhibit Aneurysm Healing after HydroCoil Implantation in External Carotid Artery Aneurysm Model. ( Chaudhary, N; Gemmete, JJ; Li, P; Pandey, AS; Thompson, BG; Xi, G; Zhang, C, 2016)
"Recently developed interventional radiologic techniques, such as embolization with platinum coils, may induce thrombus formation within an aneurysm."3.70Detection of microemboli distal to cerebral aneurysms before and after therapeutic embolization. ( Berlit, P; Henkes, H; Klötzsch, C; Kühne, D; Nahser, HC, 1998)
"Further to characterize the processes involved in the FeCl3-induced thrombosis model, we determined the effect of aspirin, heparin, hirudin, trans-4-(aminomethyl) cyclohexane carboxylic acid (AMCHA), thrombocytopenia, and flow modifications on time to occlusion (TTO) and thrombus weight (TW) in the rat carotid artery."3.70Demonstration of flow and platelet dependency in a ferric chloride-induced model of thrombosis. ( Kambayashi, J; Lockyer, S, 1999)
"Thromboxane A2 (TXA2) biosynthesis was studied in healthy subjects, patients with chronic cerebral infarction, patients under chronic aspirin treatment and patients with atrial fibrillation."3.68Urinary 11-dehydro-thromboxane B2: a quantitative index of platelet activation in cerebral infarction. ( Hayashi, Y; Nakahama, H; Nakanishi, T; Shimizu, S; Sugita, M; Takiguchi, A; Uyama, O; Yamamoto, S, 1992)
"Data from the medical treatment group of the Aspirin in TIA study were reviewed, and prospective analysis of patients with asymptomatic bruits was performed to see whether carotid stenosis (0 to 49% or 50 to 99%) or ulceration produced an increased risk of ipsilateral TIA or infarct."3.67The significance of carotid stenosis or ulceration. ( Bigelow, RH; Fields, WS; Grotta, JC; Hankins, L; Hu, H, 1984)
"Patients with carotid atherosclerotic plaques were enrolled and randomly assigned (1:1) to receive either DZSM capsules or aspirin."3.11Dengzhan Shengmai capsule versus Aspirin in the treatment of carotid atherosclerotic plaque: A single-centre, non-inferiority, prospective, randomised controlled trial. ( Jin, J; Liu, Y; Qu, L; Shen, X; Wu, J; Zou, S, 2022)
"Methods- Carotid atherosclerosis was analyzed either as the presence of mild (ie, 20%-49%) atherosclerotic stenosis or, separately, as the presence of carotid plaque."2.90Efficacy and Safety of Rivaroxaban Versus Aspirin in Embolic Stroke of Undetermined Source and Carotid Atherosclerosis. ( Amarenco, P; Berkowitz, SD; Bornstein, N; Camps-Renom, P; Connolly, SJ; Cucchiara, B; Gagliardi, RJ; Hart, RG; Korompoki, E; Lang, W; Lavados, P; Makaritsis, K; Marti-Fabregas, J; Meseguer, E; Milionis, H; Mundl, H; Ntaios, G; Papavasileiou, V; Siegler, JE; Swaminathan, B; Vemmos, K, 2019)
"Aspirin response test was evaluated 1 hour after aspirin intake using multiplate platelet function analyzer, and carotid ultrasonography has been performed to determine carotid intima-media thickness (CIMT) and the presence of carotid plaque."2.87The Relationship Between Aspirin Resistance and Carotid Imaging in Young Patients With ST-Segment Elevated Myocardial Infarction: A Cross-Sectional Study. ( Bulut, U; Demir, AR; Kalayci, B; Karakurt, H; Karakurt, ST; Serbest, NG; Somuncu, MU, 2018)
"The aspirin effect was the same across all risk-factor groups."2.66Controlled trial of aspirin in cerebral ischemia: an addendum. ( Fields, WS; Gary, HE; Lemak, NA, 1986)
"Four patients presented transient ischemic attacks, one amaurosis fugax, two suffered from a minor stroke, four had non-focalized ischemic cerebral symptoms and two were asymptomatic."2.40Fibromuscular dysplasia of the internal carotid artery. Personal experience with 13 cases and literature review. ( Limet, R; Sakalihasan, N; Van Damme, H, 1999)
" Furthermore, in assessing the potential benefits of long-term use of ASA for prophylactic purposes in these patients, one should also evaluate the side-effects and intolerance related to its chronic use, as well as its potential complications especially from a gastrointestinal perspective."2.39Aspirin in asymptomatic carotid disease. ( Côté, R, 1994)
"In children and young adults, amaurosis fugax is a benign condition."2.38Atherosclerotic carotid disease and the eye. ( Breen, LA, 1991)
" Among the anti-aggregant agents, only Aspirin at high dosage (1 to 1."2.37[The fate of patients with carotid stenosis. Comparative study, based on the literature, of their natural history and evolution under medical treatment or following endarterectomy]. ( Bachet, P; Ninet, J; Pasquier, J, 1985)
"It is also helpful in patients with amaurosis fugax, and may benefit selected patients with acute stroke or those with asymptomatic but hemodynamically significant stenosis."2.37Carotid surgery in stroke prevention. ( Busuttil, RW; Sheng, FC, 1986)
"Aspirin treatment antagonized vascular stiffening and rivaroxaban treatment led to a positive trend towards reduced stiffening."1.56Vascular protective effect of aspirin and rivaroxaban upon endothelial denudation of the mouse carotid artery. ( Brouns, AE; Chayoua, W; Coenen, DM; Cosemans, JMEM; Debets, J; Heitmeier, S; Karel, MFA; Konings, J; Korsten, EIJ; Kuijpers, MJE; Leenders, PJA; Mastenbroek, TG; Nagy, M; Spronk, HM; van Essen, H; van Oerle, R, 2020)
"Peripheral artery disease affects 1."1.51Cost-effectiveness of low-dose rivaroxaban and aspirin versus aspirin alone in people with peripheral or carotid artery disease: An Australian healthcare perspective. ( Ademi, Z; Hird, TR; Liew, D; Owen, AJ; Reid, CM; Si, S; Tonkin, A; Zomer, E, 2019)
"Ischaemic stroke is a very uncommon, but severe complication of cisplatin-based chemotherapy."1.46Internal carotid artery occlusion and stroke as a complication of cisplatin-based chemotherapy for metastatic testicular germ cell tumour. ( Azam, M; Cerrud-Rodriguez, RC; Quinteros, MG, 2017)
"Takayasu arteritis was diagnosed subsequently."1.46Complete ophthalmoplegia, complete ptosis and dilated pupil due to internal carotid artery dissection: as the first manifestation of Takayasu arteritis. ( Herath, HMMTB; Pahalagamage, SP; Senanayake, S; Withana, D, 2017)
"Onyx HD-500 is a liquid embolic used to treat intracranial aneurysms."1.39Continued concern about parent vessel steno-occlusive progression with Onyx HD-500 and the utility of quantitative magnetic resonance imaging in serial assessment. ( Alaraj, A; Aletich, VA; Amin-Hanjani, S; Carlson, AP; Charbel, FT, 2013)
"Tuberous sclerosis is an autosomal dominant inherited phakomatosis."1.36[Tuberous sclerosis and intracranial aneurysms: a rare association]. ( Aissi, M; Boughammoura-Bouatay, A; Frih-Ayed, M; Jerbi-Ommezzine, S; Sfar, MH; Younes-Mhenni, S, 2010)
"Combined carotid stenting and cardiac surgery, performed in the same operating room under only heparin and aspirin, seems a safe and effective strategy for the treatment of patients with concomitant carotid and cardiac disease."1.35Safety and effectiveness of combining carotid artery stenting with cardiac surgery: preliminary results of a single-center experience. ( Capuano, F; Faraglia, V; Palombo, G; Rizzo, L; Sinatra, R; Stella, N; Taurino, M, 2009)
"He suffered immediate loss of consciousness but recovered three days later with right-sided hemiplegia and complete aphasia."1.34Carotid occlusion and cerebral infarction from camel bite: case report. ( Laseini, A; Mahmud, MR; Nasiru, JI; Saidu, SA; Shehu, BB, 2007)
"8 patients with 9 spontaneous dissecting aneurysms of the cervical carotid artery--5 of which were symptomatic--plus one patient with ofthalmoplegia due to an aneurysm of the cavernous carotid artery were studied."1.34[Treatment of carotid artery aneurysms with covered stents]. ( Alfke, K; Bartsch, T; Dörner, L; Jansen, O; Rohr, A; Stingele, R, 2007)
"A novel model to induce occlusive thrombus formation was developed in mice in vivo."1.32A novel model of occlusive thrombus formation in mice. ( Cheng, XW; Iguchi, A; Kanda, S; Koike, T; Kuzuya, M; Maeda, K; Nakamura, K; Sasaki, T; Sato, K; Tamaya-Mori, N, 2004)
"Aspirin treatment attenuated smoking-induced changes in plaque composition."1.31Smoking increases tissue factor expression in atherosclerotic plaques: implications for plaque thrombogenicity. ( Cercek, B; Chyu, KY; Dimayuga, P; Fishbein, MC; Kangavari, S; Matetzky, S; Shah, PK; Tani, S; Xu, H; Yano, J, 2000)
"Macrophage density in carotid artery plaques classified by B-mode ultrasound imaging as echolucent (n = 56), intermediate (n = 25), or echorich (n = 25) was 1."1.31Macrophages are associated with lipid-rich carotid artery plaques, echolucency on B-mode imaging, and elevated plasma lipid levels. ( Bentzon, J; Falk, E; Grønholdt, ML; Nordestgaard, BG; Sillesen, H; Wiebe, BM; Zhou, J, 2002)
"The extent of carotid atherosclerosis was determined by real-time B-mode ultrasonography."1.29Risk factors for carotid atherosclerosis and platelet activation. ( Matsui, Y; Michishita, H; Shimizu, S; Sugita, M; Uyama, O, 1994)
"To determine whether anticoagulation practices have changed when heparin and warfarin are used to treat cerebrovascular disease, and to determine the dosage of aspirin used to treat carotid territory transient ischemic attacks (TIAs)."1.29A follow-up survey of clinical practices for the use of heparin, warfarin, and aspirin. ( Alberts, MJ; Dawson, DV; Massey, EW, 1994)
"However, their effects on thrombus formation have rarely been evaluated in experimental animals in vivo."1.29In vivo evaluation of antiplatelet agents in gerbil model of carotid artery thrombosis. ( Iwamoto, Y; Naritomi, H; Nishimura, H; Sugita, M; Tachibana, H, 1996)
"Ticlopidine was more effective in patients without carotid stenosis."1.28Prevention of stroke with ticlopidine: who benefits most? TASS Baseline and Angiographic Data Subgroup. ( Grotta, JC; Kamm, B; Norris, JW, 1992)
"Eleven of these 21 patients had cerebral infarctions while taking aspirin, and 7 of these 11 infarcts occurred without the prior warning of transient ischemic attacks."1.28Patterns of failure of aspirin treatment in symptomatic atherosclerotic carotid artery disease. ( Chen, TL; Chyatte, D, 1990)
"The frequency of a high-grade restenosis in patients with diabetes mellitus and coronary heart disease was not significantly increased, but supports the view that these are risk factors in the development of atherosclerotic changes in an operated carotid artery."1.28Late carotid restenosis: aetiologic factors for recurrent carotid artery stenosis during long-term follow-up. ( Haapanen, A; Harju, E; Jokela, H; Riekkinen, H; Salenius, JP, 1989)
"Fibromuscular dysplasia is an arteriopathy of unknown etiology that affects the intermediate-size branches of the aorta."1.28Fibromuscular dysplasia of the carotid arteries complicating pregnancy. ( Beyth, Y; Ezra, Y; Kidron, D, 1989)
" Dose-response platelet aggregometry detected no differences between groups in the sensitivity of platelets to adenosine diphosphate (ADP), collagen, and epinephrine."1.27Etiologic factors for recurrent carotid artery stenosis. ( Clagett, GP; Hutton, JE; McDonald, PT; Olson, DW; Rich, NM; Salander, JM; Youkey, JR, 1983)
"A patient is reported who sustained a cerebral infarction from carotid artery disease and was treated with aspirin."1.27Aspirin, anticoagulants, and hemorrhagic conversion of ischemic infarction: hypothesis and implications. ( Fisher, M, 1986)
"In no patient did the thrombus progress to occlude the vessel completely, and no new distal emboli were identified on the follow-up angiograms."1.27Intraluminal thrombus of the internal carotid arteries: angiographic demonstration of resolution with anticoagulant therapy alone. ( Barnett, HJ; Buchan, A; Fox, AJ; Pelz, DM; Vinuela, F, 1986)
"Delayed ipsilateral carotid arteritis is a known complication of herpes zoster ophthalmicus."1.26Transient contralateral hemiplegia after ophthalmic zoster. Therapeutic problems in elderly patients. ( Calloni, MV; Landi, G; Scarlato, G, 1981)

Research

Studies (158)

TimeframeStudies, this research(%)All Research%
pre-199055 (34.81)18.7374
1990's35 (22.15)18.2507
2000's23 (14.56)29.6817
2010's37 (23.42)24.3611
2020's8 (5.06)2.80

Authors

AuthorsStudies
Shen, X1
Zou, S1
Jin, J1
Liu, Y1
Wu, J1
Qu, L1
Ntaios, G1
Swaminathan, B1
Berkowitz, SD1
Gagliardi, RJ1
Lang, W1
Siegler, JE1
Lavados, P1
Mundl, H1
Bornstein, N1
Meseguer, E1
Amarenco, P1
Cucchiara, B1
Camps-Renom, P1
Makaritsis, K1
Korompoki, E1
Papavasileiou, V1
Marti-Fabregas, J1
Milionis, H1
Vemmos, K1
Connolly, SJ2
Hart, RG3
Tirschwell, DL1
Taylor, BL1
Gresele, P1
Paciullo, F1
Migliacci, R1
Ball, STE1
Taylor, R1
McCollum, CN2
Bulwa, Z1
Saleh Velez, FG1
Brorson, JR1
Pinto, CB1
Mastenbroek, TG1
Karel, MFA1
Nagy, M1
Chayoua, W1
Korsten, EIJ1
Coenen, DM1
Debets, J1
Konings, J1
Brouns, AE1
Leenders, PJA1
van Essen, H1
van Oerle, R1
Heitmeier, S1
Spronk, HM1
Kuijpers, MJE1
Cosemans, JMEM1
Gao, M1
Lei, J1
Ho, JP1
Galex, IA1
Sadeghi, NB1
Weledji, N1
Cabello Bermudez, SI1
Mitchell, BA1
Bush, DM1
Yap, E1
Davis, NC1
Catalino, MP1
Godfrey, V1
Nielsen, JN1
Lee, YZ1
Sasaki-Adams, DM1
Policha, A1
Williams, D1
Adelman, M1
Veith, F1
Cayne, NS1
Cerrud-Rodriguez, RC1
Quinteros, MG1
Azam, M1
Herath, HMMTB1
Pahalagamage, SP1
Withana, D1
Senanayake, S1
Aboyans, V4
Desormais, I1
Jarlan, L1
Teissier, MP1
Lacroix, P1
Anand, SS2
Bosch, J2
Eikelboom, JW2
Diaz, R1
Widimsky, P1
Alings, M1
Kakkar, AK1
Keltai, K1
Maggioni, AP1
Lewis, BS1
Störk, S1
Zhu, J1
Lopez-Jaramillo, P1
O'Donnell, M1
Commerford, PJ1
Vinereanu, D1
Pogosova, N1
Ryden, L1
Fox, KAA1
Bhatt, DL1
Misselwitz, F1
Varigos, JD1
Vanassche, T1
Avezum, AA1
Chen, E1
Branch, K1
Leong, DP1
Bangdiwala, SI1
Yusuf, S1
Antigüedad-Muñoz, J1
de la Riva, P1
Arenaza Choperena, G1
Muñoz Lopetegi, A1
Andrés Marín, N1
Fernández-Eulate, G1
Moreno Valladares, M1
Martínez Zabaleta, M1
Mant, J1
Li, W1
Chen, Z1
Dai, Z1
Liu, R1
Yin, Q1
Wang, H1
Hao, Y1
Han, Y1
Qiu, Z1
Xiong, Y1
Sun, W1
Zi, W1
Xu, G1
Liu, X1
Somuncu, MU1
Demir, AR1
Karakurt, H1
Serbest, NG1
Kalayci, B1
Bulut, U1
Karakurt, ST1
Jha, N1
Crockett, MT1
Singh, TP1
Cunningham, TK1
Draper, H1
Rajesh, U1
Zomer, E1
Si, S1
Hird, TR1
Liew, D1
Owen, AJ1
Tonkin, A1
Reid, CM1
Ademi, Z1
Pastori, D1
Patel, MR1
Tanguay, JF1
Ricco, JB1
Debus, ES1
Mazzolai, L2
Bauersachs, R1
Verhamme, P1
Nikol, S1
Nehler, M1
Violi, F1
Bender, MT1
Zarrin, DA1
Jiang, B1
Campos, JK1
Lin, LM1
Young, RW1
Colby, GP1
Coon, AL1
Naylor, AR2
Sayers, RD1
McCarthy, MJ1
Bown, MJ1
Nasim, A1
Dennis, MJ1
London, NJ1
Bell, PR1
Brown, MM1
Chehab, BM1
Gupta, K1
Mendiz, OA1
Fava, CM1
Lev, GA1
Valdivieso, LR1
Caponi, G1
Hidalgo Alava, GF1
Favaloro, RR1
Chalouhi, N1
Zanaty, M1
Tjoumakaris, S1
Gonzalez, LF1
Hasan, D1
Kung, D1
Rosenwasser, RH1
Jabbour, P1
Brodmann, M1
De Carlo, M1
Clement, D1
van Bortel, L1
van Sambeek, MR1
Vlachopoulos, C1
Jones, DW1
Goodney, PP1
Conrad, MF1
Nolan, BW2
Rzucidlo, EM1
Powell, RJ1
Cronenwett, JL1
Stone, DH2
Allende, M1
Molina, E1
Guruceaga, E1
Tamayo, I1
González-Porras, JR1
Gonzalez-López, TJ1
Toledo, E1
Rabal, O1
Ugarte, A1
Roldán, V1
Rivera, J1
Oyarzabal, J1
Montes, R1
Hermida, J1
Brenner, T1
Schmitt, FC1
Demirel, S1
Salgado, E1
Celi de la Torre, JA1
Göring, M1
Bruckner, T1
Böckler, D1
Weigand, MA1
Hofer, S1
Attigah, N1
Zhang, C1
Li, P1
Xi, G1
Gemmete, JJ1
Chaudhary, N1
Thompson, BG1
Pandey, AS1
Palombo, G1
Stella, N1
Faraglia, V1
Rizzo, L1
Capuano, F1
Sinatra, R1
Taurino, M1
Wehinger, A1
Tancevski, I1
Seiler, R1
Frotschnig, SM1
Frantz, S1
Huber, J1
Eller, P1
Schgoer, W1
Foeger, B1
Patsch, JR1
Ritsch, A1
McMahon, GS1
Webster, SE1
Hayes, PD1
Jones, CI1
Goodall, AH1
Tautenhahn, J1
Meyer, F1
Pech, M1
Michael, L1
Goertler, M1
Halloul, Z1
Enomoto, Y1
Adachi, S1
Matsushima-Nishiwaki, R1
Doi, T1
Niwa, M1
Akamatsu, S1
Tokuda, H1
Ogura, S1
Yoshimura, S1
Iwama, T1
Kozawa, O1
Daugherty, WP1
Clarke, MJ1
Cloft, HJ1
Lanzino, GL1
Ansara, AJ1
Nisly, SA1
Arif, SA1
Koehler, JM1
Nordmeyer, ST1
Aissi, M1
Younes-Mhenni, S1
Jerbi-Ommezzine, S1
Boughammoura-Bouatay, A1
Frih-Ayed, M1
Sfar, MH1
Venker, C1
Stracke, P1
Berlit, P2
Diehl, RR1
Kurre, W1
Sorgenfrei, U1
Krämer, M1
Chapot, R1
Del Zotto, E1
Ritelli, M1
Pezzini, A1
Drera, B1
Gamba, M1
Giossi, A1
Volonghi, I1
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Gasparotti, R1
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Fang, YB1
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Yang, PF1
Huang, QH1
Zhao, WY1
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Kaudewitz, D1
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Kirkby, NS1
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Langley, SR1
Sivaprasad, S1
Markus, HS2
Mitchell, JA1
Warner, TD1
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Junghans, U1
Siebler, M1
Barnett, HJ2
Meldrum, H1
Eliasziw, M1
Ferguson, GG1
Sasaki, T1
Kuzuya, M1
Cheng, XW1
Nakamura, K1
Tamaya-Mori, N1
Maeda, K1
Kanda, S1
Koike, T1
Sato, K1
Iguchi, A1
Conforto, AB1
Puglia, P1
Yamamoto, FI1
Scaff, M1
Inoue, A1
Fukumoto, SY1
Kumon, Y1
Watanabe, H1
Fumoto, N1
Oda, S1
Ohue, S1
Ohnishi, T1
Wang, X1
Cheng, Q1
Xu, L1
Feuerstein, GZ1
Hsu, MY1
Smith, PL1
Seiffert, DA1
Schumacher, WA1
Ogletree, ML1
Gailani, D1
Ballotta, E2
Thiene, G2
Baracchini, C1
Ermani, M1
Militello, C1
Da Giau, G1
Barbon, B1
Angelini, A2
Montalto, M1
Curigliano, V1
Santoro, L1
Lombardi, M1
Covino, M1
Cammarota, G1
Dalvai, S1
D'Onofrio, F1
Gasbarrini, A1
Gasbarrini, G1
Faggioli, GL1
Ferri, M1
Rossi, C1
Gargiulo, M1
Freyrie, A1
Stella, A1
Huang, R1
Patel, RB1
Ma, H1
Taylor, K1
Abela, GS1
Rohr, A1
Alfke, K1
Dörner, L1
Bartsch, T1
Stingele, R1
Jansen, O1
Weinberger, J1
Shehu, BB1
Nasiru, JI1
Mahmud, MR1
Laseini, A1
Saidu, SA1
Landi, G1
Calloni, MV1
Scarlato, G1
Bastard, J1
Goas, JY1
Born, GV1
Görög, P1
Begent, NA1
Kistler, JP1
Ropper, AH1
Heros, RC1
Clagett, GP2
Youkey, JR2
Brigham, RA1
Orecchia, PM1
Salander, JM2
Collins, GJ1
Rich, NM2
Cain, TD1
Wood, JS1
Beard, OW1
Rushton, FW1
Kukora, JS1
Grotta, JC2
Bigelow, RH1
Hu, H1
Hankins, L1
Fields, WS4
Donaldson, IM1
Bouchier-Hayes, D1
Whisnant, JP2
McDonald, PT1
Olson, DW1
Hutton, JE1
Mustard, JF1
Packham, MA1
Kinlough-Rathbone, RL1
Laiwah, AC1
Dujovny, M1
Kossovsky, N1
Loubeau, JM1
Nelson, D1
McManus, G1
Nair, KK1
Carson, SN1
Demling, RH1
Esquivel, CO1
Levin, SM1
Sondheimer, FK1
Levin, JM1
Eriksson, SE1
Côté, R1
Uyama, O2
Matsui, Y1
Shimizu, S2
Michishita, H1
Sugita, M3
Alberts, MJ1
Dawson, DV1
Massey, EW1
McCann, RL1
Ranke, C1
Hecker, H1
Creutzig, A1
Alexander, K1
Nishimura, H1
Naritomi, H1
Iwamoto, Y1
Tachibana, H1
Sivaguru, A1
Venables, GS1
Beard, JD1
Gaines, PA1
Diethrich, EB1
Ndiaye, M1
Reid, DB1
Abbruzzese, E1
Bottio, T1
Dagiau, G1
Saladini, M1
Israsena, N1
Phanthumchinda, K1
Sinsawaiwong, S1
Lerdlum, S1
Eachempati, SR1
Sebastian, MW1
Reed, RL1
Calvey, TA1
Gough, MJ1
González-Gay, MA1
García-Porrúa, C1
Brañas, F1
Klötzsch, C1
Nahser, HC1
Henkes, H1
Kühne, D1
Riggs, PN1
DeWeese, JA1
Lockyer, S1
Kambayashi, J1
Cesarone, MR1
Laurora, G1
DeSanctis, MT1
Incandela, L1
Fugazza, L1
Girardello, R1
Poli, A1
Peracino, L1
Ambrosoli, L1
Belcaro, G1
Van Damme, H1
Sakalihasan, N1
Limet, R1
Albers, GW1
Lutsep, HL1
Newell, DW1
Sacco, RL1
Matetzky, S1
Tani, S1
Kangavari, S1
Dimayuga, P1
Yano, J1
Xu, H1
Chyu, KY1
Fishbein, MC1
Shah, PK1
Cercek, B1
Stemme, V1
Swedenborg, J1
Claesson, H1
Hansson, GK1
Greenland, P1
Smith, SC1
Grundy, SM1
Grønholdt, ML1
Nordestgaard, BG1
Bentzon, J1
Wiebe, BM1
Zhou, J1
Falk, E1
Sillesen, H1
Kaposzta, Z1
Martin, JF1
Lunev, DK1
Romasenko, MV1
Kniazeva, GR1
Kutchak, EN1
Bragina, LK1
Gertz, SD1
Kurgan, A1
Wajnberg, RS1
Nelson, E1
Duncan, GW1
Pessin, MS1
Mohr, JP2
Adams, RD1
Nakanishi, T1
Nakahama, H1
Takiguchi, A1
Hayashi, Y1
Yamamoto, S1
Schulze, HE1
Ebner, A1
Besinger, UA1
Norris, JW1
Kamm, B1
Foster, RE1
Kosmorsky, GS1
Sweeney, PJ1
Masaryk, TJ1
Breen, LA1
Diener, HC1
Loherstorfer, E1
Seboldt, H1
Dichgans, J1
Widder, B1
Kleiser, B1
Krapf, H1
Reuchlin, G1
Dürr, A1
Pramsohler, B1
Lupattelli, G1
Scholz, H1
Sinzinger, H1
Kretschmer, G3
Pratschner, T2
Prager, M2
Wenzl, E2
Polterauer, P2
Schemper, M1
Ehringer, H3
Minar, E2
Horvath, R1
Holzner, H1
Völker, W1
Faber, V1
Chyatte, D1
Chen, TL1
Wade, J1
Hobson, RW2
Towne, J1
Ezra, Y1
Kidron, D1
Beyth, Y1
Salenius, JP1
Haapanen, A1
Harju, E1
Jokela, H1
Riekkinen, H1
Yeager, RA1
Moneta, GL1
McConnell, DB1
Neuwelt, EA1
Taylor, LM1
Porter, JM1
Corbeel, L1
Gewillig, M1
Baeten, E1
Casteels-Van Daele, M1
Eggermont, E1
Dudczak, R1
Schöfl, R1
Jung, M1
Koppensteiner, R1
Ahmadi, R1
Wiebers, DO1
Swanson, JW1
Cascino, TL1
Lam, JY1
Chesebro, JH1
Steele, PM1
Badimon, L1
Fuster, V1
Scheinberg, P1
Callow, AD1
Caplan, LR1
Correll, JW1
Moore, WS1
Robertson, JT1
Toole, JF1
Patterson, RH1
Gilligan, BS1
Kassirer, JP1
Kopelman, RI1
Meek, AC1
Chidlow, A1
Lane, IF1
Greenhalgh, RM1
Becker, WL1
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Sheng, FC1
Busuttil, RW1
Lemak, NA1
Gary, HE1
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Tuhrim, S1
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Rosenthal, D1
Lamis, PA1
Stanton, PE1
Clark, MD1
Ellison, RG1
Pelz, DM1
Buchan, A1
Fox, AJ1
Vinuela, F1
Geeraert, AJ1
Al Saigh, AH1
Long, JB1
Lynch, TG1
Karanfilian, RG1
Ninet, J1
Bachet, P1
Pasquier, J1
Findlay, JM1
Lougheed, WM1
Gentili, F1
Walker, PM1
Glynn, MF1
Houle, S1
Wolf, PA1
Bunt, TJ1
Haynes, JL1
Rubin, JR1
Goldstone, J1
Vroom, FQ1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Multicenter, Randomized, Double-blind, Double-dummy, Active-comparator, Event-driven, Superiority Phase III Study of Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With a Recent Embolic Stroke of Undetermined Source (ESUS),[NCT02313909]Phase 37,213 participants (Actual)Interventional2014-12-23Terminated (stopped due to Study halted early due to no efficacy improvement over aspirin at an interim analysis and very little chance of showing overall benefit if study were completed)
Platelet Function and Neurological Events Following Carotid Thromboendarterectomy[NCT05572320]386 participants (Anticipated)Observational2022-10-10Recruiting
A Randomized Controlled Trial of Rivaroxaban for the Prevention of Major Cardiovascular Events in Patients With Coronary or Peripheral Artery Disease (COMPASS - Cardiovascular OutcoMes for People Using Anticoagulation StrategieS).[NCT01776424]Phase 327,395 participants (Actual)Interventional2013-02-28Completed
Influence of Rivaroxaban 2.5 mg Two Times a Day for Intermittent Claudication and Exercise Tolerance in Patients With Symptomatic Peripheral Arterial Disease (PAD) - a Randomised Controlled Trial[NCT04305028]100 participants (Anticipated)Observational2021-03-10Not yet recruiting
DUAL Pathway Inhibition (Low-dose Rivaroxaban and Aspirin) as Compared to Aspirin Only to Improve Endothelial Function in Peripheral Artery Disease.[NCT04218656]Phase 4159 participants (Actual)Interventional2020-06-08Completed
Stent Implantation Versus Balloon Dilation for Acute Anterior Circulation Tandem Occlusion: A Multicenter, Prospective, Randomized, Open-label, Blinded End-point Trial[NCT05902000]222 participants (Anticipated)Interventional2023-06-14Recruiting
Prospective Evaluation for Hybrid Cardiac Procedures[NCT05143671]111 participants (Anticipated)Observational2021-05-13Recruiting
A Prospective, Nonrandomized, Study Comparing the Use of Aspirin and Intraoperative Blood Loss and Postoperative Complications Following Open Inguinal Hernia Repair.[NCT02084615]300 participants (Anticipated)Interventional2014-08-31Enrolling by invitation
The Characterisation of Vascular Biomarkers Before and After Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure and Their Role in Predicting Response[NCT02541773]58 participants (Anticipated)Observational2013-11-30Active, not recruiting
Evaluation of Neurological Outcome in Patients Undergoing Cerebral Angiography and Revascularization Using Angioplasty and Stent-Supported Angioplasty[NCT00597974]108 participants (Actual)Observational2003-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Incidence Rate of a Major Bleeding Event According to the International Society on Thrombosis and Haemostasis (ISTH) Criteria (Adjudicated)

Major bleeding event (as per ISTH), defined as bleeding event that met at least one of following: fatal bleeding; symptomatic bleeding in a critical area or organ (intraarticular, intramuscular with compartment syndrome, intraocular, intraspinal, pericardial, or retroperitoneal); symptomatic intracranial haemorrhage; clinically overt bleeding associated with a recent decrease in the hemoglobin level of greater than or equal to (>=) 2 grams per decilitre (g/dL) (20 grams per liter [g/L]; 1.24 millimoles per liter [mmol/L]) compared to the most recent hemoglobin value available before the event; clinically overt bleeding leading to transfusion of 2 or more units of packed red blood cells or whole blood. The results were based on classification of events that have been positively adjudicated as major bleeding events. Incidence rate estimated as number of subjects with incident events divided by cumulative at-risk time, where subject is no longer at risk once an incident event occurred. (NCT02313909)
Timeframe: From randomization until the efficacy cut-off date (median 326 days)

Interventionevent/100 participant-years (Number)
Rivaroxaban 15 mg OD1.82
Acetylsalicylic Acid 100 mg OD0.67

Incidence Rate of All-Cause Mortality

All-cause mortality includes all deaths of participants due to any cause. (NCT02313909)
Timeframe: From randomization until the efficacy cut-off date (median 326 days)

Interventionevent/100 participant-years (Number)
Rivaroxaban 15 mg OD1.88
Acetylsalicylic Acid 100 mg OD1.50

Incidence Rate of Any of the Following: Cardiovascular Death, Recurrent Stroke, Systemic Embolism and Myocardial Infarction

Incidence rate estimated as number of participants with incident events divided by cumulative at-risk time, where participant is no longer at risk once an incident event occurred. Cardiovascular death includes death due to hemorrhage and death with undetermined/unknown cause. Systemic embolism is defined as abrupt vascular insufficiency associated with clinical or radiological evidence of arterial occlusion in the absence of other likely mechanisms. The diagnosis of myocardial infarction requires the combination of: 1)evidence of myocardial necrosis (either changes in cardiac biomarkers or post-mortem pathological findings); and 2)supporting information derived from the clinical presentation, electrocardiographic changes, or the results of myocardial or coronary artery imaging. (NCT02313909)
Timeframe: From randomization until the efficacy cut-off date (median 326 days)

Interventionevent/100 participant-years (Number)
Rivaroxaban 15 mg OD6.20
Acetylsalicylic Acid 100 mg OD5.85

Incidence Rate of Clinically Relevant Non-Major Bleeding Events

Non-major clinically relevant bleeding was defined as non-major overt bleeding but required medical attention (example: hospitalization, medical treatment for bleeding), and/or was associated with the study drug interruption of more than 14 days. The results were based on the outcome events at or after randomization until the efficacy cut-off date. Incidence rate estimated as number of participants with incident events divided by cumulative at-risk time, where participant is no longer at risk once an incident event occurred. (NCT02313909)
Timeframe: From randomization until the efficacy cut-off date (median 326 days)

Interventionevent/100 participant-years (Number)
Rivaroxaban 15 mg OD3.52
Acetylsalicylic Acid 100 mg OD2.32

Incidence Rate of Intracranial Hemorrhage

Intracranial hemorrhage included all bleeding events that occurred in intracerebral, sub arachnoidal as well as subdural or epidural sites. The below table displays results for all randomized participants and the outcomes at or after randomization until the efficacy cut-off date. Incidence rate estimated as number of participants with incident events divided by cumulative at-risk time, where participant is no longer at risk once an incident event occurred. (NCT02313909)
Timeframe: From randomization until the efficacy cut-off date (median 326 days)

Interventionevent/100 participant-years (Number)
Rivaroxaban 15 mg OD0.70
Acetylsalicylic Acid 100 mg OD0.35

Incidence Rate of Life-Threatening Bleeding Events

Life-threatening bleeding was defined as a subset of major bleeding that met at least one of the following criteria: 1) fatal bleeding; 2) symptomatic intracranial haemorrhage; 3) reduction in hemoglobin of at least 5 g/dl (50 g/l; 3.10 mmol/L); 4) transfusion of at least 4 units of packed red cells or whole blood; 5) associated with hypotension requiring the use of intravenous inotropic agents; 6) necessitated surgical intervention. Incidence rate estimated as number of participants with incident events divided by cumulative at-risk time, where participant is no longer at risk once an incident event occurred. (NCT02313909)
Timeframe: From randomization until the efficacy cut-off date (median 326 days)

Interventionevent/100 participant-years (Number)
Rivaroxaban 15 mg OD1.02
Acetylsalicylic Acid 100 mg OD0.43

Incidence Rate of the Composite Efficacy Outcome (Adjudicated)

Components of composite efficacy outcome (adjudicated) includes stroke (ischemic, hemorrhagic, and undefined stroke, TIA with positive neuroimaging) and systemic embolism. Incidence rate estimated as number of participants with incident events divided by cumulative at-risk time, where participant is no longer at risk once an incident event occurred. (NCT02313909)
Timeframe: From randomization until the efficacy cut-off date (median 326 days)

Interventionevent/100 participant-years (Number)
Rivaroxaban 15 mg OD5.14
Acetylsalicylic Acid 100 mg OD4.78

Incidence Rate of the Following: Stroke, Ischemic Stroke, Disabling Stroke, Cardiovascular (CV) Death, Myocardial Infarction

"Disabling stroke is defined as stroke with modified Rankin score (mRS) greater than or equal to (>=) 4 as assessed by investigator. mRS spans 0-6, running from perfect health to death. A score of 0-3 indicates functional status ranging from no symptoms to moderate disability (defined in the mRS as requiring some help, but able to walk without assistance); mRS 4-6 indicates functional status ranging from moderately severe disability (unable to walk or to attend to own bodily needs without assistance)through to death. CV death includes death due to hemorrhage and death with undetermined/unknown cause. Diagnosis of myocardial infarction requires combination of: 1) evidence of myocardial necrosis either changes in cardiac biomarkers or post-mortem pathological findings); 2) supporting information derived from clinical presentation, electrocardiographic changes, or results of myocardial or coronary artery imaging." (NCT02313909)
Timeframe: From randomization until the efficacy cut-off date (median 326 days)

,
Interventionevent/100 participant-years (Number)
StrokeIschemic strokeDisabling strokeCV death(includes death due to hemorrhage)Myocardial infarction
Acetylsalicylic Acid 100 mg OD4.714.560.840.660.67
Rivaroxaban 15 mg OD5.114.711.200.990.49

All-cause Mortality

Count of participants and time from randomization to death by all cause were evaluated. Hazard ratios were calculated and reported as statistical analysis. (NCT01776424)
Timeframe: For each participants, death by any cause after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.

InterventionParticipants (Count of Participants)
Rivaroxaban 2.5mg + Aspirin 100mg313
Rivaroxaban 5mg + Aspirin Placebo366
Rivaroxaban Placebo + Aspirin 100mg378

All-cause Mortality in LTOLE Part

Count of participants from COMPASS LTOLE initiation visit to death by all cause were evaluated. LTOLE: long-term open-lable extension (NCT01776424)
Timeframe: For each participants, death by any cause after COMPASS LTOLE initiation visit up until the the last LTOLE part contact date was considered. The mean time in follow-up until that date was 428 days.

InterventionParticipants (Count of Participants)
LTOLE Part: Rivaroxaban 2.5mg + Aspirin 100mg282

The First Occurrence of MI, Ischemic Stroke, ALI, or Cardiovascular (CV) Death

Count of participants and time from randomization to the first occurrence of MI, ischemic stroke, ALI, or CV death were evaluated. Hazard ratios were calculated and reported as statistical analysis. (NCT01776424)
Timeframe: For each participant, the first occurrence of MI, ischemic stroke, ALI, or CV death after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.

InterventionParticipants (Count of Participants)
Rivaroxaban 2.5mg + Aspirin 100mg389
Rivaroxaban 5mg + Aspirin Placebo453
Rivaroxaban Placebo + Aspirin 100mg516

The First Occurrence of Myocardial Infarction (MI), Ischemic Stroke, Acute Limb Ischemia (ALI), or Coronary Heart Disease (CHD) Death

Count of participants and time from randomization to the first occurrence of MI, ischemic stroke, ALI, or CHD death were evaluated. Hazard ratios were calculated and reported as statistical analysis. (NCT01776424)
Timeframe: For each participant, the first occurrence of MI, ALI, or CHD death after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.

InterventionParticipants (Count of Participants)
Rivaroxaban 2.5mg + Aspirin 100mg329
Rivaroxaban 5mg + Aspirin Placebo397
Rivaroxaban Placebo + Aspirin 100mg450

The First Occurrence of the Composite Primary Efficacy Outcome, Myocardial Infarction (MI), Stroke, or Cardiovascular (CV) Death

Count of participants and time from randomization to the first occurrence of the composite primary efficacy outcome, MI, stroke, or CV death were evaluated. Hazard ratios were calculated and reported as statistical analysis. (NCT01776424)
Timeframe: For each participant, the first occurrence of the composite primary efficacy outcome after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.

InterventionParticipants (Count of Participants)
Rivaroxaban 2.5mg + Aspirin 100mg379
Rivaroxaban 5mg + Aspirin Placebo448
Rivaroxaban Placebo + Aspirin 100mg496

The First Occurrence of the Composite Primary Efficacy Outcome, Myocardial Infarction (MI), Stroke, or Cardiovascular (CV) Death in LTOLE Part

Count of participants from COMPASS LTOLE initiation visit to the first occurrence of the composite primary efficacy outcome, MI, stroke, or CV death were evaluated. LTOLE: long-term open-lable extension (NCT01776424)
Timeframe: For each participant, the first occurrence of the composite primary efficacy outcome after from COMPASS LTOLE initiation visit up until last LTOLE part contact date was considered. The mean time in follow-up was 428 days.

InterventionParticipants (Count of Participants)
LTOLE Part: Rivaroxaban 2.5mg + Aspirin 100mg353

The First Occurrence of the Primary Safety Outcome Major Bleeding Based on a Modification of the International Society on Thrombosis and Haemostasis (ISTH) Criteria

"Modified ISTH major bleeding is defined as: i) Fatal bleeding, or ii) Symptomatic bleeding in a critical area or organ, such as intraarticular, intracranial, intramuscular with compartment syndrome, intraocular, intraspinal, liver, pancreas, pericardial, respiratory, retroperitoneal, adrenal gland or kidney; or bleeding into the surgical site requiring reoperation, or iii) Bleeding leading to hospitalization (major bleeding also includes presentation to an acute care facility with discharge on the same day).~Count of participants and time from randomization to the first occurrence of the primary safety outcome major bleeding were evaluated. Hazard ratios were calculated and reported as statistical analysis." (NCT01776424)
Timeframe: For each participant, the first occurrence of modified ISTH major bleeding after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.

InterventionParticipants (Count of Participants)
Rivaroxaban 2.5mg + Aspirin 100mg288
Rivaroxaban 5mg + Aspirin Placebo255
Rivaroxaban Placebo + Aspirin 100mg170

The First Occurrence of the Primary Safety Outcome Major Bleeding Based on a Modification of the International Society on Thrombosis and Haemostasis (ISTH) Criteria in LTOLE Part

"Modified ISTH major bleeding is defined as: i) Fatal bleeding, or ii) Symptomatic bleeding in a critical area or organ, such as intraarticular, intracranial, intramuscular with compartment syndrome, intraocular, intraspinal, liver, pancreas, pericardial, respiratory, retroperitoneal, adrenal gland or kidney; or bleeding into the surgical site requiring reoperation, or iii) Bleeding leading to hospitalization (major bleeding also includes presentation to an acute care facility with discharge on the same day).~Count of participants from COMPASS LTOLE initiation visit to the first occurrence of the primary safety outcome major bleeding was evaluated. LTOLE: long-term open-lable extension" (NCT01776424)
Timeframe: For each participant, the first occurrence of modified ISTH major bleeding from COMPASS LTOLE initiation visit up until 2 days after the last treatment in LTOLE part was considered. The mean time in follow-up was 421 days.

InterventionParticipants (Count of Participants)
LTOLE Part: Rivaroxaban 2.5mg + Aspirin 100mg138

Reviews

29 reviews available for aspirin and Carotid Artery Diseases

ArticleYear
Antithrombotic treatment of asymptomatic carotid atherosclerosis: a medical dilemma.
    Internal and emergency medicine, 2020, Volume: 15, Issue:7

    Topics: Aspirin; Cardiovascular Diseases; Carotid Artery Diseases; Cerebrovascular Disorders; Fibrinolytic A

2020
Rivaroxaban plus aspirin, compared with aspirin alone, reduced cardiovascular events in patients with stable peripheral or carotid artery disease, but increased the risk of major bleeding.
    BMJ evidence-based medicine, 2018, Volume: 23, Issue:5

    Topics: Aspirin; Carotid Artery Diseases; Double-Blind Method; Hemorrhage; Humans; Rivaroxaban

2018
Management of Patients with Asymptomatic and Symptomatic Carotid Artery Disease: Update on Anti-Thrombotic Therapy.
    Thrombosis and haemostasis, 2019, Volume: 119, Issue:4

    Topics: Aged; Anticoagulants; Aspirin; Atherosclerosis; Cardiology; Cardiovascular Diseases; Carotid Arterie

2019
Closing the loop: a 21-year audit of strategies for preventing stroke and death following carotid endarterectomy.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2013, Volume: 46, Issue:2

    Topics: Angioscopy; Aspirin; Carotid Artery Diseases; Clinical Protocols; Clopidogrel; Drug Therapy, Combina

2013
Aggressive medical therapy alone is not adequate in certain patients with severe symptomatic carotid stenosis.
    Stroke, 2013, Volume: 44, Issue:10

    Topics: Aspirin; Atorvastatin; Carotid Artery Diseases; Clopidogrel; Constriction, Pathologic; Endovascular

2013
Contemporary diagnosis of carotid fibromuscular dysplasia: role of power Doppler and a review of other diagnostic modalities.
    Reviews in cardiovascular medicine, 2013, Volume: 14, Issue:2-4

    Topics: Aspirin; Cardiovascular Agents; Carotid Artery Diseases; Female; Fibromuscular Dysplasia; Humans; Ma

2013
The year in cardiology 2014: peripheral circulation.
    European heart journal, 2015, Mar-07, Volume: 36, Issue:10

    Topics: Anticoagulants; Aortic Aneurysm, Abdominal; Aspirin; Biomarkers; Carotid Artery Diseases; Endovascul

2015
Aspirin dosing for the prevention and treatment of ischemic stroke: an indication-specific review of the literature.
    The Annals of pharmacotherapy, 2010, Volume: 44, Issue:5

    Topics: Aspirin; Atherosclerosis; Carotid Artery Diseases; Dose-Response Relationship, Drug; Endothelium, Va

2010
Treatment of symptomatic arteriosclerotic carotid artery disease.
    Advances in neurology, 2003, Volume: 92

    Topics: Aspirin; Carotid Artery Diseases; Cerebral Angiography; Clinical Trials as Topic; Endarterectomy, Ca

2003
[Management of transient ischemic cerebral attacks (author's transl)].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1982, Mar-18, Volume: 58, Issue:11

    Topics: Anticoagulants; Arteriosclerosis; Aspirin; Carotid Artery Diseases; Cerebral Revascularization; Enda

1982
The biologic background to some therapeutic uses of aspirin.
    The American journal of medicine, 1983, Jun-14, Volume: 74, Issue:6A

    Topics: Animals; Arterial Occlusive Diseases; Aspirin; Carotid Artery Diseases; Coronary Disease; Humans; In

1983
Therapy of ischemic cerebral vascular disease due to atherothrombosis. (2).
    The New England journal of medicine, 1984, Jul-12, Volume: 311, Issue:2

    Topics: Anticoagulants; Arterial Occlusive Diseases; Aspirin; Auscultation; Basilar Artery; Blood Platelets;

1984
Medical Grand Rounds: extracranial carotid artery disease.
    The Journal of the Arkansas Medical Society, 1980, Volume: 76, Issue:1

    Topics: Adolescent; Adult; Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Auscultation; Carotid Art

1980
Aspirin in asymptomatic carotid disease.
    Health reports, 1994, Volume: 6, Issue:1

    Topics: Aspirin; Brain Ischemia; Carotid Artery Diseases; Carotid Stenosis; Cerebrovascular Disorders; Human

1994
Surgical management of carotid artery atherosclerotic disease.
    Southern medical journal, 1993, Volume: 86, Issue:10

    Topics: Aged; Angiography; Arteriosclerosis; Aspirin; Carotid Artery Diseases; Cause of Death; Cerebrovascul

1993
Posttraumatic bilateral carotid artery and right vertebral artery dissections in a patient with fibromuscular dysplasia: case report and review of the literature.
    The Journal of trauma, 1998, Volume: 44, Issue:2

    Topics: Accidents, Traffic; Adult; Aortic Dissection; Aspirin; Carotid Artery Diseases; Female; Fibromuscula

1998
Carotid endarterectomy.
    The Surgical clinics of North America, 1998, Volume: 78, Issue:5

    Topics: Angioplasty; Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Blood Pressure; Car

1998
Fibromuscular dysplasia of the internal carotid artery. Personal experience with 13 cases and literature review.
    Acta chirurgica Belgica, 1999, Volume: 99, Issue:4

    Topics: Aged; Aneurysm; Angioplasty, Balloon; Aspirin; Blindness; Brain Ischemia; Carotid Artery Diseases; C

1999
[Role of arterio-arterial embolisms in the pathogenesis of cerebral circulatory disorders].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1978, Volume: 78, Issue:3

    Topics: Adult; Aged; Aspirin; Basilar Artery; Blood Coagulation; Carotid Arteries; Carotid Artery Diseases;

1978
Transient cerebral ischemic attacks.
    Advances in internal medicine, 1976, Volume: 21

    Topics: Anticoagulants; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Blindn

1976
Atherosclerotic carotid disease and the eye.
    Neurologic clinics, 1991, Volume: 9, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Blindness; Carotid Artery Diseas

1991
Current management of amaurosis fugax. The Amaurosis Fugax Study Group.
    Stroke, 1990, Volume: 21, Issue:2

    Topics: Aspirin; Blindness; Carotid Arteries; Carotid Artery Diseases; Cerebrovascular Disorders; Constricti

1990
Controversies in the management of cerebral vascular disease.
    Neurology, 1988, Volume: 38, Issue:10

    Topics: Aspirin; Atrial Fibrillation; Carotid Arteries; Carotid Artery Diseases; Cerebrovascular Disorders;

1988
Stroke. An overview.
    Ophthalmology, 1988, Volume: 95, Issue:10

    Topics: Aspirin; Carotid Artery Diseases; Cerebrovascular Disorders; Clinical Trials as Topic; Endarterectom

1988
Transient ischaemic attacks: controversies in treatment. A review.
    Clinical and experimental neurology, 1988, Volume: 25

    Topics: Arterial Occlusive Diseases; Aspirin; Carotid Artery Diseases; Endarterectomy; Humans; Ischemic Atta

1988
Carotid surgery in stroke prevention.
    American family physician, 1986, Volume: 33, Issue:4

    Topics: Aged; Arteriosclerosis; Aspirin; Blindness; Carotid Arteries; Carotid Artery Diseases; Cerebrovascul

1986
The management of TIAs in 1986.
    South Dakota journal of medicine, 1986, Volume: 39, Issue:7

    Topics: Arterial Occlusive Diseases; Aspirin; Carotid Artery Diseases; Cerebrovascular Disorders; Dipyridamo

1986
Asymptomatic carotid disease.
    Surgery, gynecology & obstetrics, 1985, Volume: 160, Issue:1

    Topics: Arterial Occlusive Diseases; Aspirin; Brain Ischemia; Carotid Artery Diseases; Cerebrovascular Disor

1985
[The fate of patients with carotid stenosis. Comparative study, based on the literature, of their natural history and evolution under medical treatment or following endarterectomy].
    Journal des maladies vasculaires, 1985, Volume: 10 Suppl A

    Topics: Anticoagulants; Arteriosclerosis; Aspirin; Brain Ischemia; Carotid Artery Diseases; Combined Modalit

1985

Trials

26 trials available for aspirin and Carotid Artery Diseases

ArticleYear
Dengzhan Shengmai capsule versus Aspirin in the treatment of carotid atherosclerotic plaque: A single-centre, non-inferiority, prospective, randomised controlled trial.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 106

    Topics: Aspirin; Carotid Artery Diseases; Carotid Intima-Media Thickness; Cholesterol, LDL; Drugs, Chinese H

2022
Efficacy and Safety of Rivaroxaban Versus Aspirin in Embolic Stroke of Undetermined Source and Carotid Atherosclerosis.
    Stroke, 2019, Volume: 50, Issue:9

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carotid Artery Diseases;

2019
Ipsilateral Nonstenotic Carotid Disease in Minor Ischemic Stroke: an Exploratory Analysis of The POINT Randomized Clinical Trial.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020, Volume: 29, Issue:11

    Topics: Aged; Aspirin; Carotid Artery Diseases; Clopidogrel; Comorbidity; Double-Blind Method; Dual Anti-Pla

2020
Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.
    Lancet (London, England), 2018, 01-20, Volume: 391, Issue:10117

    Topics: Aged; Amputation, Surgical; Aspirin; Cardiovascular Diseases; Carotid Artery Diseases; Dose-Response

2018
Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.
    Lancet (London, England), 2018, 01-20, Volume: 391, Issue:10117

    Topics: Aged; Amputation, Surgical; Aspirin; Cardiovascular Diseases; Carotid Artery Diseases; Dose-Response

2018
Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.
    Lancet (London, England), 2018, 01-20, Volume: 391, Issue:10117

    Topics: Aged; Amputation, Surgical; Aspirin; Cardiovascular Diseases; Carotid Artery Diseases; Dose-Response

2018
Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.
    Lancet (London, England), 2018, 01-20, Volume: 391, Issue:10117

    Topics: Aged; Amputation, Surgical; Aspirin; Cardiovascular Diseases; Carotid Artery Diseases; Dose-Response

2018
Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.
    Lancet (London, England), 2018, 01-20, Volume: 391, Issue:10117

    Topics: Aged; Amputation, Surgical; Aspirin; Cardiovascular Diseases; Carotid Artery Diseases; Dose-Response

2018
Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.
    Lancet (London, England), 2018, 01-20, Volume: 391, Issue:10117

    Topics: Aged; Amputation, Surgical; Aspirin; Cardiovascular Diseases; Carotid Artery Diseases; Dose-Response

2018
Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.
    Lancet (London, England), 2018, 01-20, Volume: 391, Issue:10117

    Topics: Aged; Amputation, Surgical; Aspirin; Cardiovascular Diseases; Carotid Artery Diseases; Dose-Response

2018
Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.
    Lancet (London, England), 2018, 01-20, Volume: 391, Issue:10117

    Topics: Aged; Amputation, Surgical; Aspirin; Cardiovascular Diseases; Carotid Artery Diseases; Dose-Response

2018
Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.
    Lancet (London, England), 2018, 01-20, Volume: 391, Issue:10117

    Topics: Aged; Amputation, Surgical; Aspirin; Cardiovascular Diseases; Carotid Artery Diseases; Dose-Response

2018
The Relationship Between Aspirin Resistance and Carotid Imaging in Young Patients With ST-Segment Elevated Myocardial Infarction: A Cross-Sectional Study.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2018, Volume: 24, Issue:8

    Topics: Adult; Aspirin; Carotid Artery Diseases; Carotid Intima-Media Thickness; Drug Resistance; Female; Hu

2018
Aggressive medical therapy alone is not adequate in certain patients with severe symptomatic carotid stenosis.
    Stroke, 2013, Volume: 44, Issue:10

    Topics: Aspirin; Atorvastatin; Carotid Artery Diseases; Clopidogrel; Constriction, Pathologic; Endovascular

2013
Low molecular weight heparin significantly reduces embolisation after carotid endarterectomy--a randomised controlled trial.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2009, Volume: 37, Issue:6

    Topics: Adenosine Diphosphate; Aged; Anticoagulants; Arachidonic Acid; Aspirin; Carotid Artery Diseases; Dal

2009
Cerebral microembolism is blocked by tirofiban, a selective nonpeptide platelet glycoprotein IIb/IIIa receptor antagonist.
    Circulation, 2003, Jun-03, Volume: 107, Issue:21

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Carotid Artery Diseases; Clopidogrel; Female; Humans; Infus

2003
Surgical vs medical treatment for isolated internal carotid artery elongation with coiling or kinking in symptomatic patients: a prospective randomized clinical study.
    Journal of vascular surgery, 2005, Volume: 42, Issue:5

    Topics: Aged; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Female; Fibrinolytic Agents; Follo

2005
Asymptomatic cervical bruit and abnormal ocular pneumoplethysmography: a prospective study comparing two approaches to management.
    Surgery, 1984, Volume: 96, Issue:5

    Topics: Aged; Angiography; Arterial Occlusive Diseases; Aspirin; Auscultation; Carotid Arteries; Carotid Art

1984
Medical Grand Rounds: extracranial carotid artery disease.
    The Journal of the Arkansas Medical Society, 1980, Volume: 76, Issue:1

    Topics: Adolescent; Adult; Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Auscultation; Carotid Art

1980
Dose-dependent effect of aspirin on carotid atherosclerosis.
    Circulation, 1993, Volume: 87, Issue:6

    Topics: Aspirin; Carotid Artery Diseases; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hum

1993
European carotid angioplasty trial.
    Journal of endovascular surgery : the official journal of the International Society for Endovascular Surgery, 1996, Volume: 3, Issue:1

    Topics: Angioplasty, Balloon; Arterial Occlusive Diseases; Aspirin; Carotid Artery Diseases; Carotid Artery,

1996
The elongation of the internal carotid artery: early and long-term results of patients having surgery compared with unoperated controls.
    Annals of vascular surgery, 1997, Volume: 11, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Cerebrov

1997
Effects of triflusal on arteriosclerosis progression assessed with high-resolution arterial ultrasound.
    Angiology, 1999, Volume: 50, Issue:6

    Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Arteriosclerosis; Aspirin; Carotid Artery D

1999
Switching off embolization from symptomatic carotid plaque using S-nitrosoglutathione.
    Circulation, 2002, Mar-26, Volume: 105, Issue:12

    Topics: Aged; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Double-Blind Method; Female; Follo

2002
Natural history and effectiveness of aspirin in asymptomatic patient with cervical bruits. The Asymptomatic Cervical Bruit Study Group.
    Archives of neurology, 1991, Volume: 48, Issue:7

    Topics: Aspirin; Auscultation; Carotid Artery Diseases; Cerebrovascular Disorders; Follow-Up Studies; Humans

1991
Antiplatelet treatment prolongs survival after carotid bifurcation endarterectomy. Analysis of the clinical series followed by a controlled trial.
    Annals of surgery, 1990, Volume: 211, Issue:3

    Topics: Aspirin; Carotid Artery Diseases; Coronary Disease; Endarterectomy; Female; Follow-Up Studies; Human

1990
Antiplatelet therapy following carotid bifurcation endarterectomy. Evaluation of a controlled clinical trial. Prognostic significance of histologic plaque examination on behalf of survival.
    European journal of vascular surgery, 1990, Volume: 4, Issue:3

    Topics: Aged; Aspirin; Carotid Arteries; Carotid Artery Diseases; Endarterectomy; Female; Follow-Up Studies;

1990
European Stroke Prevention Study. ESPS Group.
    Stroke, 1990, Volume: 21, Issue:8

    Topics: Age Factors; Aspirin; Brain Ischemia; Carotid Artery Diseases; Cerebrovascular Disorders; Clinical T

1990
Effectiveness of carotid endarterectomy for asymptomatic carotid stenosis: design of a clinical trial. Mayo Asymptomatic Carotid Endarterectomy Study Group.
    Mayo Clinic proceedings, 1989, Volume: 64, Issue:8

    Topics: Aspirin; Carotid Arteries; Carotid Artery Diseases; Cerebrovascular Disorders; Constriction, Patholo

1989
Carotid endarterectomy: what is its current status?
    The American journal of medicine, 1988, Volume: 85, Issue:6

    Topics: Arteriosclerosis; Aspirin; Carotid Arteries; Carotid Artery Diseases; Cerebrovascular Disorders; Cli

1988
Stroke. An overview.
    Ophthalmology, 1988, Volume: 95, Issue:10

    Topics: Aspirin; Carotid Artery Diseases; Cerebrovascular Disorders; Clinical Trials as Topic; Endarterectom

1988
Controlled trial of aspirin in cerebral ischemia: an addendum.
    Neurology, 1986, Volume: 36, Issue:5

    Topics: Aspirin; Blindness; Carotid Artery Diseases; Cerebrovascular Disorders; Clinical Trials as Topic; Di

1986
Asymptomatic carotid disease.
    Surgery, gynecology & obstetrics, 1985, Volume: 160, Issue:1

    Topics: Arterial Occlusive Diseases; Aspirin; Brain Ischemia; Carotid Artery Diseases; Cerebrovascular Disor

1985
Effect of perioperative platelet inhibition on postcarotid endarterectomy mural thrombus formation. Results of a prospective randomized controlled trial using aspirin and dipyridamole in humans.
    Journal of neurosurgery, 1985, Volume: 63, Issue:5

    Topics: Aged; Aspirin; Blood Platelets; Carotid Arteries; Carotid Artery Diseases; Cerebrovascular Disorders

1985

Other Studies

107 other studies available for aspirin and Carotid Artery Diseases

ArticleYear
Is Embolic Stroke of Undetermined Source Shrinking?
    Stroke, 2019, Volume: 50, Issue:9

    Topics: Aspirin; Carotid Artery Diseases; Embolism; Humans; Rivaroxaban; Stroke

2019
Resistance to Antiplatelet Therapy Is Associated With Symptoms of Cerebral Ischemia in Carotid Artery Disease.
    Vascular and endovascular surgery, 2020, Volume: 54, Issue:8

    Topics: Aspirin; Carotid Artery Diseases; Clopidogrel; Drug Resistance; Female; Humans; Infarction, Middle C

2020
Vascular protective effect of aspirin and rivaroxaban upon endothelial denudation of the mouse carotid artery.
    Scientific reports, 2020, 11-09, Volume: 10, Issue:1

    Topics: Animals; Arteries; Aspirin; Blood Platelets; Carotid Arteries; Carotid Artery Diseases; Carotid Inti

2020
Image and clinical analysis of common carotid web: a case report.
    BMC medical imaging, 2021, 01-06, Volume: 21, Issue:1

    Topics: Aged; Anticoagulants; Aspirin; Basal Ganglia Diseases; Carotid Artery Diseases; Carotid Artery, Comm

2021
Rabbit Elastase Aneurysm: Imaging and Histology Correlates for Inflammation and Healing.
    World neurosurgery, 2021, Volume: 148

    Topics: Animals; Aspirin; Carotid Artery Diseases; Carotid Artery, Common; Disease Models, Animal; Disease P

2021
Idiopathic Carotidynia.
    Vascular and endovascular surgery, 2017, Volume: 51, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Flow Velocity; Carotid Artery Diseases; Caro

2017
Internal carotid artery occlusion and stroke as a complication of cisplatin-based chemotherapy for metastatic testicular germ cell tumour.
    BMJ case reports, 2017, Jun-18, Volume: 2017

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Aspi

2017
Complete ophthalmoplegia, complete ptosis and dilated pupil due to internal carotid artery dissection: as the first manifestation of Takayasu arteritis.
    BMC cardiovascular disorders, 2017, 07-25, Volume: 17, Issue:1

    Topics: Adult; Angiography, Digital Subtraction; Aortic Dissection; Aspirin; Blepharoptosis; Carotid Artery

2017
V. Aboyans et al. in response to the article by M. Helfre et al.: Usefulness of a systematic screening of carotid atherosclerosis in asymptomatic people with type 2 diabetes for cardiovascular risk reclassification. Ann Endocrinol (Paris). 2017;78:14-19.
    Annales d'endocrinologie, 2017, Volume: 78, Issue:5

    Topics: Aspirin; Cardiovascular Diseases; Carotid Artery Diseases; Diabetes Mellitus, Type 2; Humans; Risk F

2017
Internal Carotid Artery Web as the Cause of Recurrent Cryptogenic Ischemic Stroke.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2018, Volume: 27, Issue:5

    Topics: Adult; Aspirin; Atorvastatin; Biopsy; Brain Ischemia; Cardiovascular Agents; Carotid Artery Diseases

2018
Management of acute tandem occlusions: Stent-retriever thrombectomy with emergency stenting or angioplasty.
    The Journal of international medical research, 2018, Volume: 46, Issue:7

    Topics: Aged; Angioplasty; Arterial Occlusive Diseases; Aspirin; Brain Ischemia; Carotid Artery Diseases; Cl

2018
Unusual right internal carotid artery supraclinoid segment fenestration associated with multiple aneurysms treated with flow diversion and coiling.
    BMJ case reports, 2018, Sep-10, Volume: 2018

    Topics: Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Clopidogrel; Endovascular Procedures; Fe

2018
Management of a pregnancy with underlying fibromuscular dysplasia with a history of stroke and carotid artery dissection.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2019, Volume: 39, Issue:3

    Topics: Adult; Aortic Dissection; Aspirin; Carotid Artery Diseases; Female; Fibromuscular Dysplasia; Humans;

2019
Cost-effectiveness of low-dose rivaroxaban and aspirin versus aspirin alone in people with peripheral or carotid artery disease: An Australian healthcare perspective.
    European journal of preventive cardiology, 2019, Volume: 26, Issue:8

    Topics: Aged; Aspirin; Australia; Carotid Artery Diseases; Cost-Benefit Analysis; Decision Support Technique

2019
Aspirin Monotherapy in Flow Diversion of Selected Internal Carotid Artery Aneurysms.
    World neurosurgery, 2020, Volume: 134

    Topics: Angiography, Digital Subtraction; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Cerebr

2020
Hybrid strategy for unstable patients with severe carotid and cardiac disease requiring surgery.
    Cardiology journal, 2015, Volume: 22, Issue:1

    Topics: Aged; Angioplasty, Balloon; Anticoagulants; Aspirin; Cardiac Surgical Procedures; Carotid Artery Dis

2015
Treatment of blister-like aneurysms with the pipeline embolization device.
    Neurosurgery, 2014, Volume: 74, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angioplasty; Aspirin; Basilar Artery; Carotid Ar

2014
Dual antiplatelet therapy reduces stroke but increases bleeding at the time of carotid endarterectomy.
    Journal of vascular surgery, 2016, Volume: 63, Issue:5

    Topics: Aged; Aspirin; Asymptomatic Diseases; Carotid Artery Diseases; Chi-Square Distribution; Clopidogrel;

2016
Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk.
    Cardiovascular research, 2016, 06-01, Volume: 110, Issue:3

    Topics: Animals; Aspirin; Atrial Fibrillation; Bleeding Time; Carotid Artery Diseases; Case-Control Studies;

2016
The role of unfractionated heparin for the antiaggregatory effect of aspirin in patients undergoing carotid endarterectomy: Results of an observational clinical study.
    Vascular, 2017, Volume: 25, Issue:1

    Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Blood Coagulation; Blood Coagulation Tests; Caroti

2017
Aspirin and Clopidogrel Inhibit Aneurysm Healing after HydroCoil Implantation in External Carotid Artery Aneurysm Model.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016, Volume: 25, Issue:11

    Topics: Aneurysm; Animals; Aspirin; Carotid Artery Diseases; Carotid Artery, External; Cell Movement; Clopid

2016
Safety and effectiveness of combining carotid artery stenting with cardiac surgery: preliminary results of a single-center experience.
    The Journal of cardiovascular surgery, 2009, Volume: 50, Issue:1

    Topics: Aged; Aged, 80 and over; Angioplasty; Anticoagulants; Aspirin; Carotid Artery Diseases; Coronary Art

2009
Influence of aspirin on SR-BI expression in human carotid plaques.
    Atherosclerosis, 2009, Volume: 206, Issue:1

    Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aspirin; Atherosclerosis; Carotid

2009
[Diagnostics and treatment of carotidynia--rare angiological disease].
    Zentralblatt fur Chirurgie, 2009, Volume: 134, Issue:4

    Topics: Angiography; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carotid Artery Diseases; Carotid Arte

2009
Thromboxane A(2) promotes soluble CD40 ligand release from human platelets.
    Atherosclerosis, 2010, Volume: 209, Issue:2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aged; Aspirin; Atherosclerosis;

2010
Going viral: fusiform vertebrobasilar and internal carotid aneurysms with varicella angiitis and common variable immunodeficiency.
    Journal of neurosurgery. Pediatrics, 2009, Volume: 4, Issue:6

    Topics: Acyclovir; Adolescent; Aneurysm; Angiography, Digital Subtraction; Antiviral Agents; Aspirin; Basila

2009
Comment on "variations in the pharmacological management of patients treated with carotid endarterectomy: a survey of European vascular surgeons".
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2010, Volume: 39, Issue:6

    Topics: Aspirin; Carotid Artery Diseases; Clopidogrel; Endarterectomy, Carotid; Europe; Humans; Incidence; P

2010
[Tuberous sclerosis and intracranial aneurysms: a rare association].
    Revue neurologique, 2010, Volume: 166, Issue:11

    Topics: Adult; Anticonvulsants; Aspirin; Carbamazepine; Carotid Artery Diseases; Humans; Intracranial Aneury

2010
[New options in the therapeutic management of acute ischaemic stroke. Good results with combined i. v. and i. a. lysis and mechanical thrombectomy].
    Fortschritte der Neurologie-Psychiatrie, 2010, Volume: 78, Issue:11

    Topics: Acute Disease; Adult; Aged; Aspirin; Brain Ischemia; Carotid Artery Diseases; Cerebral Angiography;

2010
Clinical, neuroradiological and molecular features of a patient affected by pseudoxhantoma elasticum associated to carotid rete mirabile: case report.
    Clinical neurology and neurosurgery, 2012, Volume: 114, Issue:6

    Topics: Adult; Angiography, Digital Subtraction; Aspirin; Brain Ischemia; Carotid Arteries; Carotid Artery D

2012
Computed tomography angiography evaluation of internal carotid artery free-floating thrombus--single-center diagnosis, false-positives, and follow-up.
    Emergency radiology, 2012, Volume: 19, Issue:4

    Topics: Aged; Anticoagulants; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Clopidogrel; Diagn

2012
Blood loss and complications following carotid endarterectomy in patients treated with clopidogrel.
    Vascular, 2012, Volume: 20, Issue:4

    Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Carotid Artery Diseases; Clopidogrel; Drug T

2012
Sudden bilateral anterior cerebral infarction: unusual stroke associated with unusual vascular anomalies.
    Postgraduate medical journal, 2013, Volume: 89, Issue:1048

    Topics: Adult; Aspirin; Atorvastatin; Carotid Artery Diseases; Carotid Artery, Internal; Drug Therapy, Combi

2013
Treatment of blood blister-like aneurysms of the internal carotid artery with stent-assisted coil embolization.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:7

    Topics: Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Cerebral Angiography; Clopidogrel; Embol

2013
Continued concern about parent vessel steno-occlusive progression with Onyx HD-500 and the utility of quantitative magnetic resonance imaging in serial assessment.
    Neurosurgery, 2013, Volume: 72, Issue:3

    Topics: Angioplasty; Aspirin; Carotid Artery Diseases; Carotid Stenosis; Clopidogrel; Constriction, Patholog

2013
Circulating microRNAs as novel biomarkers for platelet activation.
    Circulation research, 2013, Feb-15, Volume: 112, Issue:4

    Topics: Adult; Aspirin; Biomarkers; Blood Platelets; Blood Specimen Collection; Carotid Artery Diseases; Cas

2013
A novel model of occlusive thrombus formation in mice.
    Laboratory investigation; a journal of technical methods and pathology, 2004, Volume: 84, Issue:11

    Topics: Animals; Arterial Occlusive Diseases; Aspirin; Carotid Artery Diseases; Carotid Artery, Common; Dise

2004
Progressive cervicocranial arteriopathy with dilatations and stenoses: case report.
    Arquivos de neuro-psiquiatria, 2004, Volume: 62, Issue:3B

    Topics: Adult; Arterial Occlusive Diseases; Aspirin; Basilar Artery; Carotid Artery Diseases; Carotid Artery

2004
[A case of common carotid artery dissection showing remission in short-term].
    No shinkei geka. Neurological surgery, 2005, Volume: 33, Issue:1

    Topics: Antipyrine; Aortic Dissection; Aspirin; Carotid Artery Diseases; Carotid Artery, Common; Drug Therap

2005
Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice.
    Journal of thrombosis and haemostasis : JTH, 2005, Volume: 3, Issue:4

    Topics: Animals; Arteries; Aspirin; Bleeding Time; Blood Flow Velocity; Carotid Arteries; Carotid Artery Dis

2005
Prophylactic aspirin therapy does not increase faecal calprotectin concentrations.
    European journal of gastroenterology & hepatology, 2006, Volume: 18, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Carotid Artery Diseases; Case-Control

2006
Carotid stent failure: results of surgical rescue.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2007, Volume: 33, Issue:1

    Topics: Aged; Angioplasty; Aspirin; Carotid Artery Diseases; Endarterectomy, Carotid; Female; Graft Occlusio

2007
Aspirin reduces platelet aggregation during high-energy excimer laser.
    Lasers in surgery and medicine, 2006, Volume: 38, Issue:9

    Topics: Analysis of Variance; Angioplasty, Balloon, Laser-Assisted; Animals; Aspirin; Biomarkers; Carotid Ar

2006
[Treatment of carotid artery aneurysms with covered stents].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2007, Volume: 179, Issue:10

    Topics: Adult; Alloys; Angiography, Digital Subtraction; Angioplasty; Aortic Dissection; Aspirin; Carotid Ar

2007
Antiplatelet agents for stroke prevention following transient ischemic attack.
    Southern medical journal, 2008, Volume: 101, Issue:1

    Topics: Angioplasty, Balloon; Aspirin; Carotid Artery Diseases; Clopidogrel; Dipyridamole; Drug Therapy, Com

2008
Carotid occlusion and cerebral infarction from camel bite: case report.
    East African medical journal, 2007, Volume: 84, Issue:11

    Topics: Adult; Animals; Aphasia; Aspirin; Bites and Stings; Camelus; Carotid Arteries; Carotid Artery Diseas

2007
Transient contralateral hemiplegia after ophthalmic zoster. Therapeutic problems in elderly patients.
    Journal of neurology, 1981, Volume: 224, Issue:4

    Topics: Aged; Arteritis; Aspirin; Carotid Artery Diseases; Dipyridamole; Hemiplegia; Herpes Zoster Ophthalmi

1981
Surgical management of the occluded carotid artery.
    Surgery, 1984, Volume: 96, Issue:5

    Topics: Adult; Aged; Arterial Occlusive Diseases; Aspirin; Carotid Arteries; Carotid Artery Diseases; Cerebr

1984
The significance of carotid stenosis or ulceration.
    Neurology, 1984, Volume: 34, Issue:4

    Topics: Angiography; Arterial Occlusive Diseases; Aspirin; Carotid Artery Diseases; Cerebral Infarction; Fem

1984
The lame brain at the crossroads: which therapeutic road?
    The New Zealand medical journal, 1984, Apr-25, Volume: 97, Issue:754

    Topics: Aged; Aspirin; Carotid Artery Diseases; Cerebral Infarction; Cerebrovascular Disorders; Dipyridamole

1984
Drugs in the treatment of thrombo-embolic disease--part I.
    Irish medical journal, 1983, Volume: 76, Issue:2

    Topics: Administration, Oral; Anticoagulants; Aspirin; Blood Platelets; Carotid Artery Diseases; Cerebrovasc

1983
The role of the neurologist in the decline of stroke.
    Annals of neurology, 1983, Volume: 14, Issue:1

    Topics: Anticoagulants; Aspirin; Carotid Artery Diseases; Cerebral Infarction; Cerebrovascular Disorders; En

1983
Etiologic factors for recurrent carotid artery stenosis.
    Surgery, 1983, Volume: 93, Issue:2

    Topics: Anesthesia; Arteriosclerosis; Aspirin; Carotid Artery Diseases; Constriction, Pathologic; Coronary D

1983
Non-steroidal anti-inflammatory agents and coronary heart disease.
    Acta medica Scandinavica. Supplementum, 1980, Volume: 642

    Topics: Animals; Anti-Inflammatory Agents; Arteriosclerosis; Aspirin; Blood Platelets; Blood Vessels; Caroti

1980
Transient cerebral ischaemic attacks.
    Journal of the Royal College of Physicians of London, 1982, Volume: 16, Issue:2

    Topics: Anticoagulants; Aspirin; Carotid Arteries; Carotid Artery Diseases; Diagnosis, Differential; Humans;

1982
Scanning electron microscopic and X-ray energy spectrographic analysis of the inner surface of human atherosclerotic carotid plaques.
    Neurosurgery, 1981, Volume: 8, Issue:1

    Topics: Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Dipyridamole; Female; Humans; Intracrani

1981
Carotid vascular pain--a simple treatment.
    The Laryngoscope, 1981, Volume: 91, Issue:4

    Topics: Adolescent; Adult; Arteritis; Aspirin; Carotid Artery Diseases; Female; Humans; Male; Middle Aged; P

1981
Aspirin failure in symptomatic atherosclerotic carotid artery disease.
    Surgery, 1981, Volume: 90, Issue:6

    Topics: Aged; Aspirin; Carotid Artery Diseases; Emergencies; Endarterectomy; Humans; Intracranial Arterioscl

1981
The contralateral diseased but asymptomatic carotid artery: to operate or not? An update.
    American journal of surgery, 1980, Volume: 140, Issue:2

    Topics: Arterial Occlusive Diseases; Aspirin; Carotid Artery Diseases; Cerebrovascular Disorders; Endarterec

1980
Anticoagulant treatment or antiplatelet therapy after a single carotid TIA?
    Stroke, 1995, Volume: 26, Issue:3

    Topics: Aspirin; Carotid Artery Diseases; Cerebrovascular Disorders; Follow-Up Studies; Heparin; Humans; Isc

1995
Risk factors for carotid atherosclerosis and platelet activation.
    Japanese circulation journal, 1994, Volume: 58, Issue:6

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Arteriosclerosis; Aspirin; Carotid Artery Diseases; Fem

1994
A follow-up survey of clinical practices for the use of heparin, warfarin, and aspirin.
    Neurology, 1994, Volume: 44, Issue:4

    Topics: Anticoagulants; Aspirin; Carotid Artery Diseases; Cerebrovascular Disorders; Data Collection; Follow

1994
In vivo evaluation of antiplatelet agents in gerbil model of carotid artery thrombosis.
    Stroke, 1996, Volume: 27, Issue:6

    Topics: Animals; Aspirin; Carotid Artery Diseases; Carotid Artery Injuries; Carotid Artery, Common; Cerebrov

1996
Stenting in the carotid artery: initial experience in 110 patients.
    Journal of endovascular surgery : the official journal of the International Society for Endovascular Surgery, 1996, Volume: 3, Issue:1

    Topics: Aged; Aged, 80 and over; Angioplasty, Balloon; Arterial Occlusive Diseases; Aspirin; Carotid Artery

1996
Spontaneous carotid dissection.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1997, Volume: 80, Issue:6

    Topics: Adult; Aortic Dissection; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Cerebrovascula

1997
A late complication of internal carotid artery stenting.
    Journal of vascular surgery, 1998, Volume: 27, Issue:4

    Topics: Angioplasty; Anticoagulants; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Carotid Ste

1998
Carotid occlusion mimicking giant cell arteritis.
    The Journal of rheumatology, 1998, Volume: 25, Issue:6

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Blindness; Captopril; Carotid Artery Diseas

1998
Detection of microemboli distal to cerebral aneurysms before and after therapeutic embolization.
    AJNR. American journal of neuroradiology, 1998, Volume: 19, Issue:7

    Topics: Aneurysm; Anticoagulants; Aspirin; Basilar Artery; Brain Ischemia; Carotid Artery Diseases; Carotid

1998
Demonstration of flow and platelet dependency in a ferric chloride-induced model of thrombosis.
    Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:5

    Topics: Animals; Antifibrinolytic Agents; Antithrombins; Arterial Occlusive Diseases; Aspirin; Blood Platele

1999
AHA Scientific Statement. Supplement to the guidelines for the management of transient ischemic attacks: A statement from the Ad Hoc Committee on Guidelines for the Management of Transient Ischemic Attacks, Stroke Council, American Heart Association.
    Stroke, 1999, Volume: 30, Issue:11

    Topics: Angioplasty; Anticoagulants; Aspirin; Carotid Artery Diseases; Humans; Ischemic Attack, Transient; P

1999
Smoking increases tissue factor expression in atherosclerotic plaques: implications for plaque thrombogenicity.
    Circulation, 2000, Aug-08, Volume: 102, Issue:6

    Topics: Aged; Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Aspirin; Carotid Arteries; Carotid Artery

2000
Expression of cyclo-oxygenase-2 in human atherosclerotic carotid arteries.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2000, Volume: 20, Issue:2

    Topics: Arteriosclerosis; Aspirin; Biopsy; Carotid Artery Diseases; Case-Control Studies; Cyclooxygenase 1;

2000
Improving coronary heart disease risk assessment in asymptomatic people: role of traditional risk factors and noninvasive cardiovascular tests.
    Circulation, 2001, Oct-09, Volume: 104, Issue:15

    Topics: Aged; American Heart Association; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Blood Pressure;

2001
Macrophages are associated with lipid-rich carotid artery plaques, echolucency on B-mode imaging, and elevated plasma lipid levels.
    Journal of vascular surgery, 2002, Volume: 35, Issue:1

    Topics: Analysis of Variance; Aspirin; Carotid Arteries; Carotid Artery Diseases; Carotid Stenosis; Endarter

2002
Endothelial cell damage and thrombus formation following temporary arterial occlusion. Effects of pretreatment with aspirin or heparin.
    Journal of neurosurgery, 1979, Volume: 50, Issue:5

    Topics: Animals; Aspirin; Carotid Arteries; Carotid Artery Diseases; Cerebrovascular Circulation; Endotheliu

1979
Management of the asymptomatic carotid bruit.
    American heart journal, 1979, Volume: 98, Issue:1

    Topics: Aspirin; Auscultation; Carotid Artery Diseases; Cerebral Infarction; Cerebrovascular Disorders; Enda

1979
Surgical grand rounds carotid artery surgery.
    Southern medical journal, 1976, Volume: 69, Issue:7

    Topics: Anticoagulants; Arteriovenous Shunt, Surgical; Aspirin; Carotid Arteries; Carotid Artery Diseases; C

1976
Urinary 11-dehydro-thromboxane B2: a quantitative index of platelet activation in cerebral infarction.
    Internal medicine (Tokyo, Japan), 1992, Volume: 31, Issue:6

    Topics: Adult; Aged; Arteriosclerosis; Aspirin; Atrial Fibrillation; Carotid Artery Diseases; Cerebral Infar

1992
Report of dissection of the internal carotid artery in three cases.
    Neurosurgical review, 1992, Volume: 15, Issue:1

    Topics: Angiography, Digital Subtraction; Aortic Dissection; Aspirin; Carotid Artery Diseases; Carotid Arter

1992
Prevention of stroke with ticlopidine: who benefits most? TASS Baseline and Angiographic Data Subgroup.
    Neurology, 1992, Volume: 42, Issue:1

    Topics: Aspirin; Carotid Artery Diseases; Cerebral Angiography; Cerebrovascular Disorders; Female; Humans; L

1992
Horner's syndrome secondary to spontaneous carotid dissection with normal angiographic findings.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1991, Volume: 109, Issue:11

    Topics: Angiography, Digital Subtraction; Aortic Dissection; Aspirin; Blood Pressure; Carotid Artery Disease

1991
[Carotid endarterectomy for prevention of stroke: comparison of surgical and conservative therapy].
    Der Nervenarzt, 1991, Volume: 62, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Cerebral

1991
[Rapidly progressing carotid artery stenoses: possibilities of ultrasound prediction and effect of thrombocyte aggregation inhibitors].
    VASA. Supplementum, 1990, Volume: 30

    Topics: Aspirin; Carotid Artery Diseases; Cerebrovascular Disorders; Follow-Up Studies; Humans; Intracranial

1990
Platelet scintigraphy and survival in juvenile stroke patients.
    Progress in clinical and biological research, 1990, Volume: 355

    Topics: Adult; Arteriosclerosis; Aspirin; Blood Platelets; Carotid Arteries; Carotid Artery Diseases; Cell S

1990
Aspirin reduces the growth of medial and neointimal thickenings in balloon-injured rat carotid arteries.
    Stroke, 1990, Volume: 21, Issue:12 Suppl

    Topics: Animals; Aspirin; Carotid Arteries; Carotid Artery Diseases; Carotid Artery Injuries; Male; Rats; Ra

1990
Patterns of failure of aspirin treatment in symptomatic atherosclerotic carotid artery disease.
    Neurosurgery, 1990, Volume: 26, Issue:4

    Topics: Aged; Arteriosclerosis; Aspirin; Carotid Artery Diseases; Cerebral Infarction; Humans; Middle Aged;

1990
Transient ischaemic attacks.
    The Practitioner, 1989, Aug-08, Volume: 233, Issue:1473

    Topics: Anticoagulants; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Constriction, Pathologic

1989
The role of carotid endarterectomy in asymptomatic carotid stenosis: status of the Veterans Administration study.
    Journal of vascular surgery, 1989, Volume: 9, Issue:2

    Topics: Arterial Occlusive Diseases; Aspirin; Carotid Arteries; Carotid Artery Diseases; Endarterectomy; Hum

1989
Fibromuscular dysplasia of the carotid arteries complicating pregnancy.
    Obstetrics and gynecology, 1989, Volume: 73, Issue:5 Pt 2

    Topics: Adult; Arterial Occlusive Diseases; Aspirin; Carotid Artery Diseases; Female; Fibromuscular Dysplasi

1989
Late carotid restenosis: aetiologic factors for recurrent carotid artery stenosis during long-term follow-up.
    European journal of vascular surgery, 1989, Volume: 3, Issue:3

    Topics: Adult; Aged; Aspirin; Carotid Artery Diseases; Cholesterol; Cholesterol, HDL; Constriction, Patholog

1989
Analysis of risk factors for myocardial infarction following carotid endarterectomy.
    Archives of surgery (Chicago, Ill. : 1960), 1989, Volume: 124, Issue:10

    Topics: Arteriosclerosis; Aspirin; Carotid Artery Diseases; Coronary Disease; Endarterectomy; Female; Humans

1989
Carotid and coronary artery involvement in infantile periarteritis nodosa possibly induced by Coxsackie B4 infection. Favourable course under corticosteroid treatment.
    European journal of pediatrics, 1987, Volume: 146, Issue:4

    Topics: Aspirin; Carotid Artery Diseases; Coronary Disease; Coxsackievirus Infections; Dexamethasone; Dipyri

1987
Indium-111-labeled platelet scintigraphy in carotid atherosclerosis.
    Stroke, 1989, Volume: 20, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Aspirin; Blood Platelets; Carotid Artery Diseases;

1989
Bilateral loss of vision in bright light.
    Stroke, 1989, Volume: 20, Issue:4

    Topics: Aged; Aged, 80 and over; Aspirin; Blindness; Carotid Artery Diseases; Carotid Artery, External; Caro

1989
Is vasospasm related to platelet deposition? Relationship in a porcine preparation of arterial injury in vivo.
    Circulation, 1987, Volume: 75, Issue:1

    Topics: Angioplasty, Balloon; Animals; Aspirin; Carotid Arteries; Carotid Artery Diseases; Carotid Artery In

1987
A seemingly simple decision.
    Hospital practice (Office ed.), 1987, Nov-15, Volume: 22, Issue:11

    Topics: Aged; Aspirin; Auscultation; Carotid Artery Diseases; Decision Theory; Dipyridamole; Endarterectomy;

1987
Platelet kinetics following carotid endarterectomy: the effect of aspirin and patch angioplasty.
    European journal of vascular surgery, 1988, Volume: 2, Issue:2

    Topics: Aspirin; Blood Vessel Prosthesis; Carotid Arteries; Carotid Artery Diseases; Dipyridamole; Endartere

1988
Carotid artery disease. A therapeutic enigma.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1988, Volume: 106, Issue:1

    Topics: Aspirin; Blindness; Carotid Artery Diseases; Cerebrovascular Disorders; Endarterectomy; Eye Diseases

1988
Aspirin, anticoagulants, and hemorrhagic conversion of ischemic infarction: hypothesis and implications.
    Bulletin of clinical neurosciences, 1986, Volume: 51

    Topics: Anticoagulants; Aspirin; Carotid Artery Diseases; Cerebral Hemorrhage; Cerebral Infarction; Heparin;

1986
Management of transient ischemic attacks.
    American family physician, 1986, Volume: 34, Issue:4

    Topics: Arterial Occlusive Diseases; Aspirin; Carotid Artery Diseases; Cerebrovascular Disorders; Embolism;

1986
Prevention of postoperative neurologic deficits after carotid endarterectomy. Is platelet inhibition beneficial?
    The American surgeon, 1987, Volume: 53, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Carotid Artery Diseases; Cerebrovascular Disorders; Dipyrid

1987
Intraluminal thrombus of the internal carotid arteries: angiographic demonstration of resolution with anticoagulant therapy alone.
    Radiology, 1986, Volume: 160, Issue:2

    Topics: Adult; Aged; Angiography; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Female; Hepari

1986
Spontaneous dissection of the carotid artery: an unusual cause of stroke in younger patients.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1987, Jan-01, Volume: 136, Issue:1

    Topics: Adult; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Cerebral Angiography; Cerebrovasc

1987
Transient ischemic attacks. Locating the source.
    Hospital practice (Office ed.), 1985, May-30, Volume: 20, Issue:5A

    Topics: Aged; Aspirin; Blood Coagulation; Carotid Artery Diseases; Cerebrovascular Circulation; Diagnosis, D

1985
Carotid endarterectomy. One solution to the stroke problem.
    The American surgeon, 1985, Volume: 51, Issue:2

    Topics: Adult; Aged; Arterial Occlusive Diseases; Aspirin; Carotid Arteries; Carotid Artery Diseases; Cerebr

1985
Peripheral vascular disease: treatment and referral of the elderly. Part II.
    Geriatrics, 1985, Volume: 40, Issue:7

    Topics: Aged; Arterial Occlusive Diseases; Aspirin; Brain Ischemia; Carotid Artery Diseases; Cerebrovascular

1985
Stroke: malignant and benign syndromes.
    Southern medical journal, 1973, Volume: 66, Issue:8

    Topics: Anticoagulants; Aspirin; Carotid Artery Diseases; Cerebral Hemorrhage; Cerebrovascular Disorders; De

1973