aspirin has been researched along with Carcinogenesis in 24 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite being shown to be effective for chemoprevention of colorectal cancer, aspirin has limitations including adverse effects and inability to block colitis-associated colon cancer (CAC)." | 8.31 | Combining gamma-tocopherol and aspirin synergistically suppresses colitis-associated colon tumorigenesis and modulates the gut microbiota in mice, and inhibits the growth of human colon cancer cells. ( Jiang, Q; Jones-Hall, Y; Liu, KY; Nakatsu, CH; Wang, Q, 2023) |
| "Aspirin inhibited carcinogenesis of intestinal mucosal cells in the ulcerative colitis model by inhibiting the interleukin-6/ Janus kinase/signal transducer and activator of transcription 3 signaling pathway and promoted apoptosis, thereby suppressing proliferation." | 8.12 | Aspirin Inhibits Carcinogenesis of Intestinal Mucosal Cells in UC Mice Through Inhibiting IL-6/JAK/STAT3 Signaling Pathway and Modulating Apoptosis and Proliferation. ( Chen, Y; Diao, T; Li, D; Shang, G; Shi, L; Sun, L; Yin, X, 2022) |
| "Aspirin is a chemopreventive agent for colorectal adenoma and cancer (CRC) that, like many drugs inclusive of chemotherapeutics, has been investigated for its effects on bacterial growth and virulence gene expression." | 8.02 | Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum. ( Brennan, CA; Chan, AT; Drew, DA; Gallini Comeau, CA; Garrett, WS; Glickman, JN; Nakatsu, G; Schoen, RE, 2021) |
| "The effect of aspirin on the risk of hepatocellular carcinoma (HCC) remains unclear." | 7.88 | Aspirin Use and Risk of Hepatocellular Carcinoma in a National Cohort Study of Korean Adults. ( Chang, J; Hwang, IC; Kim, K; Park, SM, 2018) |
| "Pancreatic cancer is a deadly disease with a dismal 5-year survival rate of <6%." | 5.43 | Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice. ( Bandovic, J; Mackenzie, GG; Mattheolabakis, G; Ouyang, N; Papayannis, I; Rigas, B; Vaeth, BM; Wang, R; Yang, J, 2016) |
| "Luteolin (LUT) has cancer prevention and anti-inflammatory effects." | 5.42 | Luteolin supplementation adjacent to aspirin treatment reduced dimethylhydrazine-induced experimental colon carcinogenesis in rats. ( Ahmed, ES; El-Waseef, AM; Osman, NH; Said, UZ, 2015) |
| "Despite being shown to be effective for chemoprevention of colorectal cancer, aspirin has limitations including adverse effects and inability to block colitis-associated colon cancer (CAC)." | 4.31 | Combining gamma-tocopherol and aspirin synergistically suppresses colitis-associated colon tumorigenesis and modulates the gut microbiota in mice, and inhibits the growth of human colon cancer cells. ( Jiang, Q; Jones-Hall, Y; Liu, KY; Nakatsu, CH; Wang, Q, 2023) |
| "Aspirin inhibited carcinogenesis of intestinal mucosal cells in the ulcerative colitis model by inhibiting the interleukin-6/ Janus kinase/signal transducer and activator of transcription 3 signaling pathway and promoted apoptosis, thereby suppressing proliferation." | 4.12 | Aspirin Inhibits Carcinogenesis of Intestinal Mucosal Cells in UC Mice Through Inhibiting IL-6/JAK/STAT3 Signaling Pathway and Modulating Apoptosis and Proliferation. ( Chen, Y; Diao, T; Li, D; Shang, G; Shi, L; Sun, L; Yin, X, 2022) |
| "Aspirin is a chemopreventive agent for colorectal adenoma and cancer (CRC) that, like many drugs inclusive of chemotherapeutics, has been investigated for its effects on bacterial growth and virulence gene expression." | 4.02 | Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum. ( Brennan, CA; Chan, AT; Drew, DA; Gallini Comeau, CA; Garrett, WS; Glickman, JN; Nakatsu, G; Schoen, RE, 2021) |
| "The effect of aspirin on the risk of hepatocellular carcinoma (HCC) remains unclear." | 3.88 | Aspirin Use and Risk of Hepatocellular Carcinoma in a National Cohort Study of Korean Adults. ( Chang, J; Hwang, IC; Kim, K; Park, SM, 2018) |
| "Breast cancer is the most ubiquitous type of neoplasms among women worldwide." | 2.66 | Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions. ( Manoharan, R; Natarajan, SR; Ponnusamy, L; Thangaraj, K, 2020) |
| "Globally, colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the second leading cause of cancer death." | 2.61 | Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. ( Giovannucci, E; Keum, N, 2019) |
| "However, its role in thyroid cancer stem cell maintenance remains elusive." | 1.48 | Estrogen receptor β upregulated by lncRNA-H19 to promote cancer stem-like properties in papillary thyroid carcinoma. ( Chai, HF; Cui, XN; Deng, ZQ; Hou, ZJ; Lam, EW; Li, J; Li, M; Li, MM; Liang, QL; Liu, Q; Lv, SS; Mao, KG; Meng, YT; Peng, F; Sun, DX; Tong, MY; Wang, XC; Xu, J; Yu, X; Zhang, L; Zhang, LZ; Zhang, QQ; Zhao, Y; Zou, H, 2018) |
| "For our study, we used two colon cancer cell lines isolated from the same donor but characterized by different metastatic potential, SW480 (nonmetastatic) and SW620 (metastatic) cancer cells, and a pancreatic cancer cell line, PANC-1 (nonmetastatic)." | 1.46 | Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC. ( McCarty, OJ; Mitrugno, A; Ngo, AT; Pang, J; Sears, RC; Sylman, JL; Williams, CD, 2017) |
| "Pancreatic cancer is a deadly disease with a dismal 5-year survival rate of <6%." | 1.43 | Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice. ( Bandovic, J; Mackenzie, GG; Mattheolabakis, G; Ouyang, N; Papayannis, I; Rigas, B; Vaeth, BM; Wang, R; Yang, J, 2016) |
| "Luteolin (LUT) has cancer prevention and anti-inflammatory effects." | 1.42 | Luteolin supplementation adjacent to aspirin treatment reduced dimethylhydrazine-induced experimental colon carcinogenesis in rats. ( Ahmed, ES; El-Waseef, AM; Osman, NH; Said, UZ, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 13 (54.17) | 24.3611 |
| 2020's | 11 (45.83) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 1 |
| Sun, L | 2 |
| Li, D | 1 |
| Yin, X | 1 |
| Shang, G | 1 |
| Diao, T | 1 |
| Shi, L | 1 |
| Li, Y | 1 |
| He, X | 1 |
| Lu, X | 1 |
| Gong, Z | 1 |
| Li, Q | 1 |
| Zhang, L | 3 |
| Yang, R | 1 |
| Wu, C | 1 |
| Huang, J | 1 |
| Ding, J | 1 |
| He, Y | 1 |
| Liu, W | 1 |
| Chen, C | 2 |
| Cao, B | 1 |
| Zhou, D | 1 |
| Shi, Y | 1 |
| Chen, J | 1 |
| Wang, C | 1 |
| Zhang, S | 1 |
| Zhang, J | 1 |
| Ye, J | 1 |
| You, H | 1 |
| Liu, KY | 1 |
| Wang, Q | 2 |
| Nakatsu, CH | 1 |
| Jones-Hall, Y | 1 |
| Jiang, Q | 1 |
| Patrono, C | 1 |
| Suo, C | 1 |
| Zhang, T | 2 |
| Shen, S | 1 |
| Gu, X | 2 |
| Qiu, S | 1 |
| Zhang, P | 1 |
| Wei, H | 2 |
| Ma, W | 1 |
| Yan, R | 1 |
| Chen, R | 1 |
| Jia, W | 1 |
| Cao, J | 1 |
| Zhang, H | 1 |
| Gao, P | 1 |
| Keum, N | 1 |
| Giovannucci, E | 1 |
| Ma, WY | 1 |
| Wang, K | 1 |
| Chang, X | 1 |
| Johnson, ML | 1 |
| Bai, R | 1 |
| Bode, AM | 1 |
| Foster, NR | 1 |
| Falk, GW | 1 |
| Limburg, PJ | 1 |
| Iyer, PG | 1 |
| Dong, Z | 1 |
| Zhuo, M | 1 |
| Chen, W | 1 |
| Shang, S | 1 |
| Guo, P | 1 |
| Peng, K | 1 |
| Li, M | 2 |
| Mo, P | 1 |
| Zhang, Y | 2 |
| Qiu, X | 1 |
| Li, W | 1 |
| Yu, C | 1 |
| Clapper, ML | 1 |
| Chang, WL | 1 |
| Cooper, HS | 1 |
| Zhao, R | 1 |
| Coker, OO | 1 |
| Wu, J | 1 |
| Zhou, Y | 1 |
| Zhao, L | 1 |
| Nakatsu, G | 2 |
| Bian, X | 1 |
| Chan, AWH | 1 |
| Sung, JJY | 1 |
| Chan, FKL | 1 |
| El-Omar, E | 1 |
| Yu, J | 1 |
| Ponnusamy, L | 1 |
| Natarajan, SR | 1 |
| Thangaraj, K | 1 |
| Manoharan, R | 1 |
| D'Orazio, JA | 1 |
| Brennan, CA | 1 |
| Gallini Comeau, CA | 1 |
| Drew, DA | 1 |
| Glickman, JN | 1 |
| Schoen, RE | 1 |
| Chan, AT | 1 |
| Garrett, WS | 1 |
| Wang, X | 2 |
| Shojaie, A | 1 |
| Shelley, D | 1 |
| Lampe, PD | 1 |
| Levy, L | 1 |
| Peters, U | 1 |
| Potter, JD | 1 |
| White, E | 1 |
| Lampe, JW | 1 |
| Hwang, IC | 1 |
| Chang, J | 1 |
| Kim, K | 1 |
| Park, SM | 1 |
| Santucci-Pereira, J | 1 |
| Pogash, TJ | 1 |
| Patel, A | 1 |
| Hundal, N | 1 |
| Barton, M | 1 |
| Camoirano, A | 1 |
| Micale, RT | 1 |
| La Maestra, S | 1 |
| Balansky, R | 1 |
| De Flora, S | 1 |
| Russo, J | 1 |
| Song, JM | 1 |
| Upadhyaya, P | 1 |
| Kassie, F | 1 |
| Chai, HF | 1 |
| Peng, F | 1 |
| Meng, YT | 1 |
| Zhang, LZ | 1 |
| Zou, H | 1 |
| Liang, QL | 1 |
| Li, MM | 1 |
| Mao, KG | 1 |
| Sun, DX | 1 |
| Tong, MY | 1 |
| Deng, ZQ | 1 |
| Hou, ZJ | 1 |
| Zhao, Y | 2 |
| Li, J | 2 |
| Wang, XC | 1 |
| Lv, SS | 1 |
| Zhang, QQ | 1 |
| Yu, X | 1 |
| Lam, EW | 1 |
| Liu, Q | 1 |
| Cui, XN | 1 |
| Xu, J | 1 |
| Wang, T | 1 |
| Fu, X | 1 |
| Jin, T | 1 |
| Liu, B | 1 |
| Wu, Y | 1 |
| Xu, F | 1 |
| Ye, K | 1 |
| Zhang, W | 1 |
| Ye, L | 1 |
| Wang, L | 1 |
| Liu, Y | 1 |
| Akiyama, K | 1 |
| Qu, C | 1 |
| Jin, Y | 1 |
| Shi, S | 1 |
| Li, C | 1 |
| Lee, PS | 1 |
| Sun, Y | 1 |
| Zhang, E | 1 |
| Guo, Y | 1 |
| Wu, CL | 1 |
| Auricchio, N | 1 |
| Priolo, C | 1 |
| Csibi, A | 1 |
| Parkhitko, A | 1 |
| Morrison, T | 1 |
| Planaguma, A | 1 |
| Kazani, S | 1 |
| Israel, E | 1 |
| Xu, KF | 1 |
| Henske, EP | 1 |
| Blenis, J | 1 |
| Levy, BD | 1 |
| Kwiatkowski, D | 1 |
| Yu, JJ | 1 |
| Osman, NH | 1 |
| Said, UZ | 1 |
| El-Waseef, AM | 1 |
| Ahmed, ES | 1 |
| Mattheolabakis, G | 1 |
| Papayannis, I | 1 |
| Yang, J | 1 |
| Vaeth, BM | 1 |
| Wang, R | 1 |
| Bandovic, J | 1 |
| Ouyang, N | 1 |
| Rigas, B | 1 |
| Mackenzie, GG | 1 |
| Mitrugno, A | 1 |
| Sylman, JL | 1 |
| Ngo, AT | 1 |
| Pang, J | 1 |
| Sears, RC | 1 |
| Williams, CD | 1 |
| McCarty, OJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Possible Protective Effect of Pentoxifylline Against Chemotherapy Induced Toxicities in Patients With Colorectal Cancer[NCT05590117] | Early Phase 1 | 48 participants (Anticipated) | Interventional | 2022-10-11 | Enrolling by invitation | ||
| Diet obEsity sMoking Epigenetics geneTics biomaRkers Physical Activity: An International Multicenter Case-control Study on Endogenous and Exogenous Risk Factors in Early-onset Colorectal Cancer[NCT05732623] | 2,300 participants (Anticipated) | Observational [Patient Registry] | 2022-12-05 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for aspirin and Carcinogenesis
| Article | Year |
|---|---|
Cyclooxygenase Inhibitors and Cancer: The Missing Pieces.
Topics: Aspirin; Carcinogenesis; Colorectal Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 | 2023 |
Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies.
Topics: Age Factors; Age of Onset; Aspirin; Calcium; Carcinogenesis; Colorectal Neoplasms; Diet; Early Detec | 2019 |
Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies.
Topics: Age Factors; Age of Onset; Aspirin; Calcium; Carcinogenesis; Colorectal Neoplasms; Diet; Early Detec | 2019 |
Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies.
Topics: Age Factors; Age of Onset; Aspirin; Calcium; Carcinogenesis; Colorectal Neoplasms; Diet; Early Detec | 2019 |
Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies.
Topics: Age Factors; Age of Onset; Aspirin; Calcium; Carcinogenesis; Colorectal Neoplasms; Diet; Early Detec | 2019 |
Dysplastic Aberrant Crypt Foci: Biomarkers of Early Colorectal Neoplasia and Response to Preventive Intervention.
Topics: Aberrant Crypt Foci; Adenoma; Adenomatous Polyposis Coli Protein; Animals; Antineoplastic Agents; As | 2020 |
Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Aspirin; Biological Products; Breast | 2020 |
Aspirin's Protective Effects Highlight the Role of Inflammation in UV-Induced Skin Damage and Carcinogenesis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carcinogenesis; Humans; Radiodermatitis; Ultraviol | 2021 |
2 trials available for aspirin and Carcinogenesis
| Article | Year |
|---|---|
Targeting the COX1/2-Driven thromboxane A2 pathway suppresses Barrett's esophagus and esophageal adenocarcinoma development.
Topics: Adenocarcinoma; Animals; Aspirin; Barrett Esophagus; Carcinogenesis; Cell Line, Tumor; Cell Prolifer | 2019 |
Exploratory plasma proteomic analysis in a randomized crossover trial of aspirin among healthy men and women.
Topics: Adult; Aspirin; beta Catenin; Carcinogenesis; Cross-Over Studies; Double-Blind Method; Female; Human | 2017 |
17 other studies available for aspirin and Carcinogenesis
| Article | Year |
|---|---|
Aspirin Inhibits Carcinogenesis of Intestinal Mucosal Cells in UC Mice Through Inhibiting IL-6/JAK/STAT3 Signaling Pathway and Modulating Apoptosis and Proliferation.
Topics: Animals; Apoptosis; Aspirin; Azoxymethane; Carcinogenesis; Cell Proliferation; Colitis, Ulcerative; | 2022 |
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Topics: Acetylation; Aspirin; Breast Neoplasms; Carcinogenesis; Female; Humans; Interleukin-6; Methyltransfe | 2022 |
Combining gamma-tocopherol and aspirin synergistically suppresses colitis-associated colon tumorigenesis and modulates the gut microbiota in mice, and inhibits the growth of human colon cancer cells.
Topics: Animals; Aspirin; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colonic Ne | 2023 |
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
Topics: Arachidonic Acid; Aspirin; Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; | 2023 |
Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling.
Topics: Anilides; Animals; Aspirin; Carcinogenesis; Cell Proliferation; Colitis; Colorectal Neoplasms; Disea | 2020 |
Aspirin Reduces Colorectal Tumor Development in Mice and Gut Microbes Reduce its Bioavailability and Chemopreventive Effects.
Topics: Adenomatous Polyposis Coli Protein; Animals; Anti-Bacterial Agents; Anticarcinogenic Agents; Aspirin | 2020 |
Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum.
Topics: Adenoma; Animals; Aspirin; Bacteria; Carcinogenesis; Cell Transformation, Neoplastic; Colon; Colorec | 2021 |
Aspirin Use and Risk of Hepatocellular Carcinoma in a National Cohort Study of Korean Adults.
Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carcinogenesis; Carcinom | 2018 |
Aspirin abrogates impairment of mammary gland differentiation induced by early in life second-hand smoke in mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carcinogenesis; Cel | 2018 |
Nitric oxide-donating aspirin (NO-Aspirin) suppresses lung tumorigenesis in vitro and in vivo and these effects are associated with modulation of the EGFR signaling pathway.
Topics: A549 Cells; Animals; Aspirin; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell | 2018 |
Estrogen receptor β upregulated by lncRNA-H19 to promote cancer stem-like properties in papillary thyroid carcinoma.
Topics: Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Agents; Aspirin; Carcinogenesis; Cell Line, | 2018 |
Aspirin targets P4HA2 through inhibiting NF-κB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma.
Topics: Animals; Aspirin; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell P | 2019 |
IFN-γ and TNF-α synergistically induce mesenchymal stem cell impairment and tumorigenesis via NFκB signaling.
Topics: Animals; Aspirin; Carcinogenesis; Cell Differentiation; Female; Genes, fos; Genes, myc; Interferon-g | 2013 |
Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.
Topics: Analysis of Variance; Animals; Aspirin; Breath Tests; Carcinogenesis; Carrier Proteins; Cell Prolife | 2014 |
Luteolin supplementation adjacent to aspirin treatment reduced dimethylhydrazine-induced experimental colon carcinogenesis in rats.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Aspirin; Carcinoembryonic Ant | 2015 |
Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice.
Topics: Animals; Antineoplastic Agents; Aspirin; Carcinogenesis; Cell Proliferation; Chemoprevention; Female | 2016 |
Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC.
Topics: Aspirin; Blood Platelets; Carcinogenesis; Cell Communication; Cell Line, Tumor; Cell Proliferation; | 2017 |