aspirin and Cancer of Stomach studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

Excerpt	Relevance	Reference
"We examined the effect of aspirin on survival following resection for squamous cell carcinoma (SCC) of the esophagus or adenocarcinoma of the gastric cardia."	9.14	A preliminary study on the postoperative survival of patients given aspirin after resection for squamous cell carcinoma of the esophagus or adenocarcinoma of the cardia. ( Drew, PA; Jamieson, GG; Liu, JF; Wu, TC; Zhu, GJ, 2009)
" Overall survival and cancer-specific survival of esophageal, gastric and colorectal cancers among aspirin users were compared with those among non-aspirin users."	9.05	Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis. ( Cao, LL; Chen, QY; Huang, CM; Li, P; Lin, JL; Lin, JX; Lin, M; Lu, J; Wang, JB; Xie, JW; Zheng, CH, 2020)
" We found that regular aspirin use was associated with lower risk of gastric adenocarcinoma among women, but not men."	8.12	Association Between Aspirin Use and Gastric Adenocarcinoma: A Prospective Cohort Study. ( Bao, Y; Cao, Y; Chan, AT; Drew, DA; Flynn, JJ; Fuchs, CS; Giovannucci, EL; Klempner, SJ; Kwon, S; Leonardo, BM; Ma, W; Song, M, 2022)
"Low-dose aspirin use may reduce cancer incidence and mortality, but its influence on gastric adenocarcinoma survival is unclear."	8.12	Aspirin use in relation to long-term survival after gastrectomy for gastric adenocarcinoma. ( Asplund, J; Holmberg, D; Kauppila, JH; Lagergren, J; Leijonmarck, W; Mattsson, F; Xie, SH, 2022)
"This cohort study with <10 years of follow-up suggests metformin use may not prevent gastric adenocarcinoma."	7.91	Metformin use and risk of gastric adenocarcinoma in a Swedish population-based cohort study. ( Lagergren, J; Santoni, G; Xie, SH; Zheng, J, 2019)
"To investigate the inhibitory effect of arsenic trioxide, aspirin and their combination on the growth of human gastric adenocarcinoma SGC-7901 graft in nude mice."	7.75	[Effect of arsenic trioxide combined with aspirin on the growth of human gastric adenocarcinoma graft in nude mice]. ( Liu, H; Qiu, J; Wu, YP, 2009)
"Preclinical, epidemiological, and randomised data indicate that aspirin might prevent tumour development and metastasis, leading to reduced cancer mortality, particularly for gastro-oesophageal and colorectal cancer."	5.30	Aspirin as an adjuvant treatment for cancer: feasibility results from the Add-Aspirin randomised trial. ( Adams, R; Berkman, L; Bridgewater, J; Cafferty, F; Cameron, D; Crossley, A; Din, F; Falk, S; Gilbert, D; Graham, J; Gupta, K; Henson, V; Hubner, R; Iveson, T; Jankowski, J; Joharatnam-Hogan, N; Khabra, K; Kunene, V; Kynaston, H; Langley, R; Patel, K; Pramesh, CS; Ring, A; Rowley, S; Sothi, S; Swinson, D; Thomas, A; Underwood, T; Warner, N; Wilson, R, 2019)
" These occurred only in the groups given MNNG in combination with stress, aspirin, or sodium taurocholate, and did not occur in experimental groups given either MNNG, stress, aspirin, or sodium taurocholate alone, and did not occur in the control group."	5.27	Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate. ( Cohen, A; Geller, SA; Horowitz, I; Toth, LS; Werther, JL, 1984)
"We examined the effect of aspirin on survival following resection for squamous cell carcinoma (SCC) of the esophagus or adenocarcinoma of the gastric cardia."	5.14	A preliminary study on the postoperative survival of patients given aspirin after resection for squamous cell carcinoma of the esophagus or adenocarcinoma of the cardia. ( Drew, PA; Jamieson, GG; Liu, JF; Wu, TC; Zhu, GJ, 2009)
" Overall survival and cancer-specific survival of esophageal, gastric and colorectal cancers among aspirin users were compared with those among non-aspirin users."	5.05	Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis. ( Cao, LL; Chen, QY; Huang, CM; Li, P; Lin, JL; Lin, JX; Lin, M; Lu, J; Wang, JB; Xie, JW; Zheng, CH, 2020)
"Along with the growing elderly population, patients with gastric ulcers caused by low-dose aspirin have increased."	4.86	[Differential diagnosis of gastric ulcer and gastric cancer in elderly patients]. ( Akamatsu, T; Arakura, N; Ito, T; Iwaya, Y; Nagaya, T; Suga, T, 2010)
"Aspirin and other NSAIDs are showing promise in the chemoprevention of colorectal cancer."	4.80	Non-steroidal anti-inflammatory drugs and chemoprevention of cancer. ( Morgan, G; Vainio, H, 2000)
"Replacement of thienopyridine with aspirin or cilostazol may be acceptable for minimizing both the risk of post-ESD bleeding and thromboembolism in patients with EGC."	4.31	Association between perioperative management of antiplatelet agents and risk of post-endoscopic submucosal dissection bleeding in early gastric cancer: analysis of a nationwide multicenter study. ( Asahina, Y; Fujishiro, M; Hasatani, K; Hatta, W; Hayashi, Y; Hikichi, T; Hoteya, S; Iguchi, M; Inoue, T; Kikuchi, D; Kiyotoki, S; Kobayashi, M; Kuribayashi, S; Mabe, K; Masamune, A; Matsumura, T; Michida, T; Mikami, T; Miura, Y; Morita, Y; Nagami, Y; Nakamatsu, D; Narasaka, T; Nebiki, H; Nishikawa, J; Ohnita, K; Sugimoto, M; Sumiyoshi, T; Suzuki, H; Tomida, H; Tsuji, S; Tsuji, Y; Ueyama, H; Yabuuchi, Y; Yada, T; Yamaguchi, S; Yoshio, T, 2023)
" However, among former aspirin users and never smokers, there could be a reduction of gastric distal adenocarcinoma risk with a higher adherence to a Mediterranean diet."	4.31	Diet quality and risk of gastric adenocarcinoma: The Multiethnic Cohort. ( Acuna, N; Boushey, C; Hébert, JR; Le Marchand, L; Park, SY; Setiawan, VW; Wilkens, LR; Wu, AH, 2023)
" We found that regular aspirin use was associated with lower risk of gastric adenocarcinoma among women, but not men."	4.12	Association Between Aspirin Use and Gastric Adenocarcinoma: A Prospective Cohort Study. ( Bao, Y; Cao, Y; Chan, AT; Drew, DA; Flynn, JJ; Fuchs, CS; Giovannucci, EL; Klempner, SJ; Kwon, S; Leonardo, BM; Ma, W; Song, M, 2022)
"Low-dose aspirin use may reduce cancer incidence and mortality, but its influence on gastric adenocarcinoma survival is unclear."	4.12	Aspirin use in relation to long-term survival after gastrectomy for gastric adenocarcinoma. ( Asplund, J; Holmberg, D; Kauppila, JH; Lagergren, J; Leijonmarck, W; Mattsson, F; Xie, SH, 2022)
"This cohort study with <10 years of follow-up suggests metformin use may not prevent gastric adenocarcinoma."	3.91	Metformin use and risk of gastric adenocarcinoma in a Swedish population-based cohort study. ( Lagergren, J; Santoni, G; Xie, SH; Zheng, J, 2019)
" We evaluated the effects of aspirin on genetic/epigenetic alterations in precancerous conditions, i."	3.85	Effects of long-term aspirin use on molecular alterations in precancerous gastric mucosa in patients with and without gastric cancer. ( Das, KM; Fukui, H; Hara, K; Ito, C; Kondo, T; Kono, T; Michigami, Y; Miwa, H; Morimoto, T; Oshima, T; Tomita, T; Tozawa, K; Watari, J; Yamasaki, T, 2017)
"The aim of this study was to investigate whether aspirin use can reduce the incidence of gastric cancer in patients with hypertension or type 2 diabetes."	3.83	Long-Term Low-Dose Aspirin Use Reduces Gastric Cancer Incidence: A Nationwide Cohort Study. ( Choi, IJ; Kim, JH; Kim, SY; Kim, YI; Kim, YW; Lee, JH; Park, JH; Ryu, KW, 2016)
"To investigate the inhibitory effect of arsenic trioxide, aspirin and their combination on the growth of human gastric adenocarcinoma SGC-7901 graft in nude mice."	3.75	[Effect of arsenic trioxide combined with aspirin on the growth of human gastric adenocarcinoma graft in nude mice]. ( Liu, H; Qiu, J; Wu, YP, 2009)
"We aimed to explore whether risk of postoperative hemorrhage due to aspirin differs in the East and the West."	2.82	The risk of aspirin induced postoperative hemorrhage: a systematic review and meta-analysis. ( Chen, Y; Ding, Z; Han, C; Lin, R; Ling, X; Liu, J; Nie, C; Sheng, L, 2022)
"The protective effect of statin against gastric cancer was also significant in patients with diabetes mellitus."	2.82	Aspirin, metformin, and statin use on the risk of gastric cancer: A nationwide population-based cohort study in Korea with systematic review and meta-analysis. ( Bang, CS; Kim, HH; Kim, J; Kim, JY; Kim, TJ; Lee, KJ; Park, CH; Seo, SI; Shin, WG; You, SC, 2022)
"Add-Aspirin is a phase III, multi-centre, double-blind, placebo-controlled randomised trial with four parallel cohorts."	2.82	ADD-ASPIRIN: A phase III, double-blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours. ( Berkman, L; Cafferty, FH; Cameron, D; Coyle, C; Gilbert, D; Gupta, S; Kynaston, H; Langley, RE; MacKenzie, M; Pramesh, CS; Ring, A; Rowley, S; Wilson, RH, 2016)
" The dose-response analysis and subgroup analysis were also performed."	2.55	Aspirin and non-steroidal anti-inflammatory drugs use reduce gastric cancer risk: A dose-response meta-analysis. ( Chen, WJ; Chen, Y; Huang, XZ; Sun, SS; Wu, CC; Wu, J; Zhang, CY; Zhang, X, 2017)
"Recent studies in esophagogastric cancer help clarify the role of radiation therapy in surgical management, as well as the role of chemotherapeutic and targeted agents."	2.53	An update in the nonendoscopic treatment of gastric cancer. ( Ilson, DH, 2016)
"Inflammation is a non-specific immune response to infection, irritation or other injury, the key features being redness, warmth, swelling and pain."	2.49	Immunoinflammatory responses in gastrointestinal tract injury and recovery. ( Alam, MM; Marella, A; Shaquiquzzaman, M; Verma, G, 2013)
" The dose-response meta-analysis was performed by linear trend regression and restricted cubic spline regression."	2.49	Frequency-risk and duration-risk relationships between aspirin use and gastric cancer: a systematic review and meta-analysis. ( Chen, S; Fu, J; Gao, Y; Liu, L; Yang, Y; Ye, X, 2013)
" There are now more than 15 epidemiological (case-control and cohort) studies indicating that long-term use of aspirin is associated with a reduced risk of colorectal cancer."	2.41	Aspirin and cancer risk: an update to 2001. ( Bosetti, C; Gallus, S; La Vecchia, C, 2002)
"The relative risk of colorectal cancer is about 0."	2.41	Nonsteroidal anti-inflammatory drugs and the gastrointestinal tract. Extent, mode, and dose dependence of anticancer effects. ( Sjödahl, R, 2001)
"Aspirin has been well known for its anti-pyretic and anti-inflammatory action over the past century."	2.40	Aspirin induced apoptosis in gastric cancer cells. ( Lam, SK; Wong, BC; Zhu, GH, 1999)
"Gastric cancer is one of the most common and deadly cancers among men and women and is the third leading cause of cancer mortality worldwide."	1.62	Preparation of novel anthraquinone-based aspirin derivatives with anti-cancer activity. ( Bai, Y; Fan, Y; Li, D; Li, S; Li, Y; Lin, S; Wang, Z; Zhang, S; Zhang, Y, 2021)
" In conclusion, long-term use of aspirin was independently associated with reduced incidence and mortality of gastric cancer in the general population, but metformin or statin use was only associated with a reduction of gastric cancer mortality in patients with diabetes and in the general population, respectively."	1.62	Association of Aspirin, Metformin, and Statin Use with Gastric Cancer Incidence and Mortality: A Nationwide Cohort Study. ( Cho, MH; Jeong, SM; Shin, DW; Yoo, TG, 2021)
"We identified 727 incident cases of gastric cancer and 1394 incident cases of oesophageal cancer."	1.56	Low-dose aspirin and risk of gastric and oesophageal cancer: A population-based study in the United Kingdom using The Health Improvement Network. ( Cea Soriano, L; García Rodríguez, LA; Soriano-Gabarró, M; Vora, P, 2020)
"A total of 597 patients with gastric neoplasms treated with ESD between January 2010 and June 2017 were enrolled."	1.51	Feasibility of gastric endoscopic submucosal dissection with continuous low-dose aspirin for patients receiving dual antiplatelet therapy. ( Amano, Y; Harada, H; Hayasaka, K; Katsuyama, Y; Murakami, D; Nagasaka, T; Nakahara, R; Sagami, R; Suehiro, S; Ujihara, T, 2019)
"The risk of gastric cancer (GC) declines after Helicobacter pylori (H."	1.51	DNA methylation silencing of microRNA gene methylator in the precancerous background mucosa with and without gastric cancer: Analysis of the effects of H. pylori eradication and long-term aspirin use. ( Das, KM; Fukui, H; Ito, C; Miwa, H; Oshima, T; Shimoda, T; Tomita, T; Watari, J, 2019)
"Many studies have found evidence that aspirin has protective effects against certain cancers, but quantitative dose-response data have been available only on a limited basis."	1.48	Cumulative Dose Threshold for the Chemopreventive Effect of Aspirin Against Gastric Cancer. ( Banerjee, S; Chang, J; Kim, MH; Kim, WJ; Park, SM, 2018)
"Aspirin use was associated with a reduced GC risk (HR = 0."	1.48	Aspirin and Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study. ( Chan, EW; Chen, L; Cheung, KS; Leung, WK; Seto, WK; Wong, AYS; Wong, ICK, 2018)
"For in vitro experiments, human gastric cancer cell lines were used to confirm the cancer cell growth and inhibition by reducing the platelet count or using aspirin."	1.43	Antitumor effect of antiplatelet agents in gastric cancer cells: an in vivo and in vitro study. ( Doki, Y; Kurokawa, Y; Mikami, J; Miyata, H; Miyazaki, Y; Mori, M; Nakajima, K; Takahashi, T; Takiguchi, S; Yamasaki, M, 2016)
"Epidemiological studies on aspirin and stomach cancer have been inconclusive."	1.42	Regular aspirin use and stomach cancer risk in China. ( Duan, H; Ge, J; Shen, C; Wang, Y, 2015)
"The risk of postoperative hemorrhage following gastric ESD was higher in patients with antithrombotic therapy than in those without that therapy."	1.39	The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection. ( Edogawa, S; Harada, S; Higuchi, K; Kojima, Y; Ota, K; Takeuchi, T; Tokioka, S; Umegaki, E, 2013)
"Patients who underwent ESD for early gastric neoplasms at the National Cancer Center Hospital, Korea, between November 2008 and January 2011 were enrolled."	1.38	Aspirin use and bleeding risk after endoscopic submucosal dissection in patients with gastric neoplasms. ( Cho, SJ; Choi, IJ; Kim, CG; Kim, HJ; Kim, YW; Kwak, MH; Lee, JH; Lee, JY; Nam, BH; Ryu, KW, 2012)
"The incidence of esophageal and gastric cancers was high at 5."	1.36	Impact of upper gastrointestinal lesions in patients on low-dose aspirin therapy: preliminary study. ( Kawai, T; Watanabe, M; Yamashina, A, 2010)
"Aspirin (5 mM) treatment of MKN28 gastric epithelial monolayers significantly decreased transepithelial electrical resistance and increased dextran permeability."	1.35	Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7. ( Joh, T; Miwa, H; Oshima, T, 2008)
"Apoptosis in gastric cancer cells expressing wild-type p53 is induced through up-regulation of bax and down-regulation of bcl-2 and that regulation of the bax-bcl-2 heterodimer may be a major target of NSAIDs."	1.35	Susceptibility for NSAIDs-induced apoptosis correlates to p53 gene status in gastric cancer cells. ( Dai, Q; Li, EL; Shen, GF; Wu, SM; Xiao, SD; Zhang, YJ; Zhu, HY, 2008)
"First we analyzed 66 gastric cancer samples of Asian and Caucasian patients for the presence of EGFR mutations."	1.33	Acetylsalicylic acid enhances antiproliferative effects of the EGFR inhibitor gefitinib in the absence of activating mutations in gastric cancer. ( Becker, JC; Berdel, WE; Brandts, C; Domschke, W; Fujimori, T; Ilea, AM; Müller-Tidow, C; Pohle, T; Serve, H; Stolte, M; Tickenbrock, L; Tidow, N, 2006)
"Proliferation of gastric cancer cell lines treated with octreotide or aspirin was determined by (3)H-thymidine incorporation."	1.32	Effects of combined octreotide and aspirin on the growth of gastric cancer. ( Tang, C; Tang, L; Wang, C, 2003)
"Aspirin could inhibit the AP-1 binding activation stimulated by fetal calf serum."	1.32	[Inhibition effect of aspirin on the growth of gastric cancer and the mechanism there-in involved]. ( Tang, C; Wang, C, 2003)
"pylori-mediated NF-kappaB activation on gastric cancer cells."	1.31	H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells. ( Akanuma, M; Hirata, Y; Maeda, S; Mitsuno, Y; Ogura, K; Omata, M; Shiratori, Y; Yamaji, Y; Yoshida, H, 2000)
"A case-control study of stomach cancer which includes 448 cases and 610 hospital controls has been conducted in Moscow, Russia."	1.30	Aspirin protects against gastric cancer: results of a case-control study from Moscow, Russia. ( Borisova, E; Chkhikvadze, V; Maximovitch, D; Zaridze, D, 1999)
"We have reported reduced risk of fatal colon cancer among persons who used aspirin in a large prospective study."	1.29	Aspirin use and risk of fatal cancer. ( Calle, EE; Flanders, WD; Heath, CW; Namboodiri, MM; Thun, MJ, 1993)
" These occurred only in the groups given MNNG in combination with stress, aspirin, or sodium taurocholate, and did not occur in experimental groups given either MNNG, stress, aspirin, or sodium taurocholate alone, and did not occur in the control group."	1.27	Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate. ( Cohen, A; Geller, SA; Horowitz, I; Toth, LS; Werther, JL, 1984)

Timeframe	Studies, this research(%)	All Research%
pre-1990	22 (18.64)	18.7374
1990's	7 (5.93)	18.2507
2000's	28 (23.73)	29.6817
2010's	41 (34.75)	24.3611
2020's	20 (16.95)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Barrett's Esophagus Study (BEST) Trial - a Multi-Center and Endoscopic Outcomes Project[NCT00586404]				1,250 participants (Actual)	Observational	2007-11-30	Terminated (stopped due to lack of enrollment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Aspirin, metformin, and statin use on the risk of gastric cancer: A nationwide population-based cohort study in Korea with systematic review and meta-analysis. Cancer medicine, 2022, Volume: 11, Issue:4 Topics: Aspirin; Cohort Studies; Diabetes Mellitus; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors;	2022
The risk of aspirin induced postoperative hemorrhage: a systematic review and meta-analysis. Expert review of gastroenterology & hepatology, 2022, Volume: 16, Issue:10 Topics: Aspirin; Endoscopic Mucosal Resection; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Platelet	2022
Preventing Metachronous Gastric Cancer after the Endoscopic Resection of Gastric Epithelial Neoplasia: Roles of Gut and liver, 2020, 05-15, Volume: 14, Issue:3 Topics: Aspirin; Endoscopic Mucosal Resection; Female; Gastric Mucosa; Gastritis, Atrophic; Helicobacter Inf	2020
Aspirin and Reducing Risk of Gastric Cancer: Systematic Review and Meta-Analysis of the Observational Studies. Journal of gastrointestinal and liver diseases : JGLD, 2020, Jun-03, Volume: 29, Issue:2 Topics: Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Duration of Therapy; Humans; P	2020
Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis. BMC cancer, 2020, Jul-09, Volume: 20, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Esophageal Neoplasms; Humans	2020
Low-Dose Aspirin Use Does Not Increase Survival in 2 Independent Population-Based Cohorts of Patients With Esophageal or Gastric Cancer. Gastroenterology, 2018, Volume: 154, Issue:4 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Databases, Factual; Engla	2018
Gastric cancer chemoprevention: the current evidence. Gastroenterology clinics of North America, 2013, Volume: 42, Issue:2 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2 Inhibitors	2013
Immunoinflammatory responses in gastrointestinal tract injury and recovery. Acta biochimica Polonica, 2013, Volume: 60, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Biogenic Polyamines; Biomarkers; Cyc	2013
Frequency-risk and duration-risk relationships between aspirin use and gastric cancer: a systematic review and meta-analysis. PloS one, 2013, Volume: 8, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Publication Bias; Regression Analysis; Ris	2013
Aspirin and proton pump inhibitor combination therapy for prevention of cardiovascular disease and Barrett's esophagus. Postgraduate medicine, 2014, Volume: 126, Issue:1 Topics: Aspirin; Barrett Esophagus; Cardiovascular Diseases; Colorectal Neoplasms; Drug Combinations; Gastro	2014
An update in the nonendoscopic treatment of gastric cancer. Current opinion in gastroenterology, 2016, Volume: 32, Issue:6 Topics: Anticarcinogenic Agents; Aspirin; Chemotherapy, Adjuvant; Esophagogastric Junction; Gastrectomy; Hum	2016
Aspirin and non-steroidal anti-inflammatory drugs use reduce gastric cancer risk: A dose-response meta-analysis. Oncotarget, 2017, Jan-17, Volume: 8, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardia; Dose-Response Relationship, Drug; Female;	2017
Chemoprevention in gastrointestinal adenocarcinoma: for few but not for all? Minerva gastroenterologica e dietologica, 2008, Volume: 54, Issue:4 Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; ErbB Recepto	2008
Aspirin use and the risk of gastric cancer: a meta-analysis. Digestive diseases and sciences, 2010, Volume: 55, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Chi-Square Distribution;	2010
[Differential diagnosis of gastric ulcer and gastric cancer in elderly patients]. Nihon rinsho. Japanese journal of clinical medicine, 2010, Volume: 68, Issue:11 Topics: Aged; Aspirin; Diagnosis, Differential; Humans; Stomach Neoplasms; Stomach Ulcer	2010
Aspirin and cancer risk: an update to 2001. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2002, Volume: 11, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Case-Control Studies; Cohort Stu	2002
Prevention of cancer in the upper gastrointestinal tract with COX-inhibition. Still an option? Current pharmaceutical design, 2007, Volume: 13, Issue:22 Topics: Adenocarcinoma; Anticarcinogenic Agents; Aspirin; Cardiovascular Diseases; Cell Transformation, Neop	2007
Aspirin induced apoptosis in gastric cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1999, Volume: 53, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Hum	1999
Non-steroidal anti-inflammatory drugs and chemoprevention of cancer. Annales chirurgiae et gynaecologiae, 2000, Volume: 89, Issue:3 Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; beta Carotene; Case-Control Studie	2000
Nonsteroidal anti-inflammatory drugs and the gastrointestinal tract. Extent, mode, and dose dependence of anticancer effects. The American journal of medicine, 2001, Jan-08, Volume: 110, Issue:1A Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Colorectal Neopl	2001
Gastritis. The Medical clinics of North America, 1974, Volume: 58, Issue:6 Topics: Animals; Aspirin; Atropine; Bile Acids and Salts; Cell Membrane Permeability; Ethanol; Gastric Juice	1974

Article	Year
Aspirin as an adjuvant treatment for cancer: feasibility results from the Add-Aspirin randomised trial. The lancet. Gastroenterology & hepatology, 2019, Volume: 4, Issue:11 Topics: Aged; Antineoplastic Agents; Aspirin; Breast Neoplasms; Colorectal Neoplasms; Combined Modality Ther	2019
ADD-ASPIRIN: A phase III, double-blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours. Contemporary clinical trials, 2016, Volume: 51 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Chemotherapy, Adjuvant; Colorect	2016
A preliminary study on the postoperative survival of patients given aspirin after resection for squamous cell carcinoma of the esophagus or adenocarcinoma of the cardia. Annals of surgical oncology, 2009, Volume: 16, Issue:5 Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Carcinoma, Squamous C	2009

Article	Year
Association Between Aspirin Use and Gastric Adenocarcinoma: A Prospective Cohort Study. Cancer prevention research (Philadelphia, Pa.), 2022, 04-01, Volume: 15, Issue:4 Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Follow-Up Studies; Humans;	2022
Aspirin use in relation to long-term survival after gastrectomy for gastric adenocarcinoma. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2022, Volume: 25, Issue:3 Topics: Adenocarcinoma; Aspirin; Cohort Studies; Gastrectomy; Humans; Neoplasm Staging; Stomach Neoplasms	2022
Role of Aspirin in Gastric Cancer Prevention. Cancer prevention research (Philadelphia, Pa.), 2022, 04-01, Volume: 15, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Female; Gastrointestinal Neoplas	2022
Aspirin Use and Gastric Adenocarcinoma-Letter. Cancer prevention research (Philadelphia, Pa.), 2022, 08-01, Volume: 15, Issue:8 Topics: Adenocarcinoma; Aspirin; Gastric Mucosa; Humans; Stomach Neoplasms	2022
Aspirin Use and Gastric Adenocarcinoma-Reply. Cancer prevention research (Philadelphia, Pa.), 2022, 08-01, Volume: 15, Issue:8 Topics: Adenocarcinoma; Aspirin; Gastric Mucosa; Humans; Stomach Neoplasms	2022
Association between perioperative management of antiplatelet agents and risk of post-endoscopic submucosal dissection bleeding in early gastric cancer: analysis of a nationwide multicenter study. Gastrointestinal endoscopy, 2023, Volume: 97, Issue:5 Topics: Aspirin; Cilostazol; Endoscopic Mucosal Resection; Gastric Mucosa; Gastrointestinal Hemorrhage; Gast	2023
Diet quality and risk of gastric adenocarcinoma: The Multiethnic Cohort. The American journal of clinical nutrition, 2023, Volume: 117, Issue:1 Topics: Adenocarcinoma; Aspirin; Cohort Studies; Diet; Diet, Mediterranean; Humans; Risk Factors; Stomach Ne	2023
Gastric cancer risk in the elderly is associated with omeprazole use and inversely associated with aspirin use. European journal of gastroenterology & hepatology, 2023, 09-01, Volume: 35, Issue:9 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Omeprazole; Risk; Stomach Neoplasms	2023
DNA methylation silencing of microRNA gene methylator in the precancerous background mucosa with and without gastric cancer: Analysis of the effects of H. pylori eradication and long-term aspirin use. Scientific reports, 2019, 08-29, Volume: 9, Issue:1 Topics: Aged; Aspirin; Cohort Studies; DNA Methylation; Female; Gastric Mucosa; Gene Silencing; Helicobacter	2019
Metformin use and risk of gastric adenocarcinoma in a Swedish population-based cohort study. British journal of cancer, 2019, Volume: 121, Issue:10 Topics: Adenocarcinoma; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diabetes Mellitus; Fe	2019
Long-term use of proton pump inhibitors does not affect ectopic and metachronous recurrence of gastric cancer after endoscopic treatment. Scandinavian journal of gastroenterology, 2020, Volume: 55, Issue:2 Topics: Aged; Aged, 80 and over; Aspirin; Female; Gastroscopy; Helicobacter Infections; Histamine H2 Antagon	2020
Low-dose aspirin and risk of gastric and oesophageal cancer: A population-based study in the United Kingdom using The Health Improvement Network. International journal of cancer, 2020, 11-01, Volume: 147, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studi	2020
Evaluation of implementation of risk management guidelines for carriers of pathogenic variants in mismatch repair genes: a nationwide audit of familial cancer clinics. Familial cancer, 2020, Volume: 19, Issue:4 Topics: Adult; Anticarcinogenic Agents; Aspirin; Colonoscopy; Colorectal Neoplasms; Colorectal Neoplasms, He	2020
Continued Aspirin Treatment May Be a Risk Factor of Delayed Bleeding after Gastric Endoscopic Submucosal Dissection under Heparin Replacement: A Retrospective Multicenter Study. Internal medicine (Tokyo, Japan), 2020, Nov-01, Volume: 59, Issue:21 Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Endoscopic Mucosal Resection; Female; Heparin; Hum	2020
Association of Aspirin, Metformin, and Statin Use with Gastric Cancer Incidence and Mortality: A Nationwide Cohort Study. Cancer prevention research (Philadelphia, Pa.), 2021, Volume: 14, Issue:1 Topics: Adult; Aged; Aspirin; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Mal	2021
Preparation of novel anthraquinone-based aspirin derivatives with anti-cancer activity. European journal of pharmacology, 2021, Jun-05, Volume: 900 Topics: Anthraquinones; Antineoplastic Agents; Apoptosis; Aspirin; Cell Line, Tumor; Cyclooxygenase 1; Cyclo	2021
Timing of bleeding and thromboembolism associated with endoscopic submucosal dissection for gastric cancer in Japan. Journal of gastroenterology and hepatology, 2021, Volume: 36, Issue:10 Topics: Anticoagulants; Aspirin; Endoscopic Mucosal Resection; Fibrinolytic Agents; Gastric Mucosa; Humans;	2021
Effects of long-term aspirin use on molecular alterations in precancerous gastric mucosa in patients with and without gastric cancer. Scientific reports, 2017, 10-17, Volume: 7, Issue:1 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; CpG	2017
Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden. BMJ open, 2017, Oct-30, Volume: 7, Issue:10 Topics: Adenocarcinoma; Adult; Age Factors; Aged; Aged, 80 and over; Aspirin; Cohort Studies; Female; Gastro	2017
Aspirin and Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study. Journal of the National Cancer Institute, 2018, 07-01, Volume: 110, Issue:7 Topics: Adult; Aged; Aspirin; Chemoprevention; Clarithromycin; Cohort Studies; Drug Therapy, Combination; Fe	2018
Continuous Use of Thienopyridine May Be as Safe as Low-Dose Aspirin in Endoscopic Resection of Gastric Tumors. Gut and liver, 2018, 07-15, Volume: 12, Issue:4 Topics: Aged; Aged, 80 and over; Aspirin; Drug Administration Schedule; Endoscopic Mucosal Resection; Female	2018
Cumulative Dose Threshold for the Chemopreventive Effect of Aspirin Against Gastric Cancer. The American journal of gastroenterology, 2018, Volume: 113, Issue:6 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Dose-Response Relatio	2018
Comparison of the effects of antithrombotic therapy on delayed bleeding after gastric endoscopic resection: a propensity score-matched case-control study. Gastrointestinal endoscopy, 2019, Volume: 89, Issue:2 Topics: Aged; Anticoagulants; Antithrombins; Aspirin; Case-Control Studies; Deprescriptions; Endoscopic Muco	2019
Effect of Continued Administration of Low-dose Aspirin for Intraoperative Bleeding Control in Gastric Endoscopic Submucosal Dissection. Digestion, 2019, Volume: 100, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Case-Control Studies; Endoscopic Muco	2019
Feasibility of gastric endoscopic submucosal dissection with continuous low-dose aspirin for patients receiving dual antiplatelet therapy. World journal of gastroenterology, 2019, Jan-28, Volume: 25, Issue:4 Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Endoscopic Mucosal Resection; Feasibility Studies; Fe	2019
Response to He et al. The American journal of gastroenterology, 2019, Volume: 114, Issue:3 Topics: Aspirin; Humans; Stomach Neoplasms	2019
Targeting the differentiation of gastric cancer cells (KATO‑III) downregulates epithelial‑mesenchymal and cancer stem cell markers. Oncology reports, 2019, Volume: 42, Issue:2 Topics: Apoptosis; Aspirin; Biomarkers, Tumor; Cell Cycle; Cell Differentiation; Cell Movement; Cell Prolife	2019
[Guidelines for the diagnosis and treatment of Helicobacter pylori infection in Korea, 2013 revised edition]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2013, Volume: 62, Issue:1 Topics: Amoxicillin; Anti-Bacterial Agents; Aspirin; Bismuth; Breath Tests; Clarithromycin; Gastroesophageal	2013
The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection. BMC gastroenterology, 2013, Sep-06, Volume: 13 Topics: Adenoma; Aged; Anti-Ulcer Agents; Anticoagulants; Aspirin; Carcinoma; Case-Control Studies; Clopidog	2013
Continued use of low-dose aspirin does not increase the risk of bleeding during or after endoscopic submucosal dissection for early gastric cancer. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2014, Volume: 17, Issue:3 Topics: Aged; Aged, 80 and over; Aspirin; Dissection; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; G	2014
Risk factors for early and delayed post-operative bleeding after endoscopic submucosal dissection of gastric neoplasms, including patients with continued use of antithrombotic agents. BMC gastroenterology, 2014, Oct-03, Volume: 14 Topics: Adenocarcinoma; Aged; Aspirin; Dissection; Female; Fibrinolytic Agents; Gastric Mucosa; Gastroscopy;	2014
Regular aspirin use and stomach cancer risk in China. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2015, Volume: 41, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Mass Index; Case-Control Studies; China; Fema	2015
Long-Term Low-Dose Aspirin Use Reduces Gastric Cancer Incidence: A Nationwide Cohort Study. Cancer research and treatment, 2016, Volume: 48, Issue:2 Topics: Adult; Aged; Aspirin; Cohort Studies; Comorbidity; Diabetes Mellitus, Type 2; Female; Humans; Hypert	2016
On Trial: Evidence From Using Aspirin to Prevent Cancer. Journal of the National Cancer Institute, 2015, Volume: 107, Issue:9 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Clinical Trials as	2015
Antitumor effect of antiplatelet agents in gastric cancer cells: an in vivo and in vitro study. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2016, Volume: 19, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood Platelets; Cell Prolifer	2016
[75h birthday of D. G. Zaridze]. Voprosy onkologii, 2015, Volume: 61, Issue:6 Topics: Anticarcinogenic Agents; Aspirin; Authorship; Carcinogens; History, 20th Century; History, 21st Cent	2015
Aspirin-induced mucosal cell death in human gastric cells: role of a caspase-independent mechanism. Digestive diseases and sciences, 2009, Volume: 54, Issue:1 Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis Inducing Factor; Aspir	2009
Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7. American journal of physiology. Cell physiology, 2008, Volume: 295, Issue:3 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Claudins; Dextrans; Dose-Response	2008
Susceptibility for NSAIDs-induced apoptosis correlates to p53 gene status in gastric cancer cells. Cancer investigation, 2008, Volume: 26, Issue:9 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Aspirin; bcl-2-Associated	2008
Chronic aspirin use suppresses CDH1 methylation in human gastric mucosa. Digestive diseases and sciences, 2010, Volume: 55, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antigens, CD; Aspirin; Cadherins;	2010
Nonsteroidal antiinflammatory drugs and risk of gastric adenocarcinoma: the multiethnic cohort study. American journal of epidemiology, 2009, Aug-15, Volume: 170, Issue:4 Topics: Adenocarcinoma; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Female	2009
[Effect of arsenic trioxide combined with aspirin on the growth of human gastric adenocarcinoma graft in nude mice]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2009, Volume: 29, Issue:5 Topics: Adenocarcinoma; Animals; Arsenic Trioxide; Arsenicals; Aspirin; bcl-2-Associated X Protein; Humans;	2009
[Pseudoneoplastic regeneration of the stomach. Histopathology and differential diagnosis]. Der Pathologe, 2010, Volume: 31, Issue:3 Topics: Aspirin; Carcinoma; Diagnosis, Differential; Gastritis; Helicobacter Infections; Humans; Intestinal	2010
Impact of upper gastrointestinal lesions in patients on low-dose aspirin therapy: preliminary study. Journal of gastroenterology and hepatology, 2010, Volume: 25 Suppl 1 Topics: Aged; Aspirin; Cardiovascular Agents; Duodenal Ulcer; Endoscopy, Digestive System; Esophageal Neopla	2010
Endoscopic submucosal dissection with electrosurgical knives in a patient on aspirin therapy (with video). Gastrointestinal endoscopy, 2010, Volume: 72, Issue:5 Topics: Aged; Aspirin; Dissection; Electrosurgery; Female; Gastric Mucosa; Humans; Platelet Aggregation Inhi	2010
Aspirin and gastric cancer risk. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2010, Volume: 19, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Case-Control Studies; Hum	2010
A retrospective study demonstrating properties of nonvariceal upper gastrointestinal bleeding in Turkey. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2011, Volume: 22, Issue:3 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Comorbidity; Endoscopy, Gastrointestinal; Fe	2011
Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carboxylesterase; Carboxylic Ester Hydrol	2012
Should antiplatelets be stopped before gastric mucosectomy? For how long and in whom? Endoscopy, 2012, Volume: 44, Issue:2 Topics: Aspirin; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male; Platelet Ag	2012
Aspirin use and bleeding risk after endoscopic submucosal dissection in patients with gastric neoplasms. Endoscopy, 2012, Volume: 44, Issue:2 Topics: Adenocarcinoma; Adenoma; Aged; Aspirin; Cardiovascular Diseases; Female; Gastric Mucosa; Gastrointes	2012
[A case for proton pump blocker... When cough comes from the stomach]. MMW Fortschritte der Medizin, 2002, Nov-07, Volume: 144, Issue:45 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antirheumatic Age	2002
Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer. Oncogene, 2003, Feb-27, Volume: 22, Issue:8 Topics: Active Transport, Cell Nucleus; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; As	2003
Effects of combined octreotide and aspirin on the growth of gastric cancer. Chinese medical journal, 2003, Volume: 116, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Humans; Male; Mice; Mice, Inbred B	2003
[Inhibition effect of aspirin on the growth of gastric cancer and the mechanism there-in involved]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2003, Volume: 34, Issue:3 Topics: Adenocarcinoma; Aspirin; Cell Division; Cyclooxygenase 2; Humans; Isoenzymes; Membrane Proteins; Pro	2003
[ACUTE DIGESTIVE HEMORRHAGES]. El Dia medico, 1963, Sep-19, Volume: 35 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticoagulants; Aspirin; Gastrointestinal Hemo	1963
Gastroprotection by vitamin C--a heme oxygenase-1-dependent mechanism? Biochemical and biophysical research communications, 2003, Dec-12, Volume: 312, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Aspirin; Cell Line, Tumor; Dose-Response Rel	2003
PPARgamma mediates NSAIDs-induced upregulation of TFF2 expression in gastric epithelial cells. FEBS letters, 2004, Jan-30, Volume: 558, Issue:1-3 Topics: Anilides; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line, Tumor; Dose-Response Relation	2004
[Helicobacter pylori: changes of indications for eradication therapy]. Deutsche medizinische Wochenschrift (1946), 2004, Sep-03, Volume: 129 Suppl 2 Topics: Anti-Bacterial Agents; Anti-Ulcer Agents; Aspirin; Drug Therapy, Combination; Gastroesophageal Reflu	2004
Aspirin-induced mucosal cell death in human gastric cells: evidence supporting an apoptotic mechanism. Digestive diseases and sciences, 2004, Volume: 49, Issue:9 Topics: Apoptosis; Aspirin; Blotting, Western; Caspases; Cell Survival; DNA, Neoplasm; Dose-Response Relatio	2004
Activation of the caspase-8/Bid and Bax pathways in aspirin-induced apoptosis in gastric cancer. Carcinogenesis, 2005, Volume: 26, Issue:3 Topics: Apoptosis; Aspirin; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Carrie	2005
Low-dose aspirin affects the clinicopathological features of gastric cancer. Digestion, 2006, Volume: 73, Issue:1 Topics: Aged; Aspirin; Case-Control Studies; Chi-Square Distribution; Female; Humans; Male; Neoplasm Staging	2006
Acetylsalicylic acid enhances antiproliferative effects of the EGFR inhibitor gefitinib in the absence of activating mutations in gastric cancer. International journal of oncology, 2006, Volume: 29, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Blotting, Western; Cell Sur	2006
Aspirin-induced apoptosis in human gastric cancer epithelial cells: relationship with protein kinase C signaling. Digestive diseases and sciences, 2007, Volume: 52, Issue:3 Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Caspases; Cell Line, Tu	2007
Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. The Journal of surgical research, 2008, Volume: 145, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Caspase Inhibitors; Cell Line, Tumor; C	2008
Effects of sodium chloride, saccharin, phenobarbital and aspirin on gastric carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine. Gan, 1984, Volume: 75, Issue:6 Topics: Adenocarcinoma; Animals; Aspirin; Carcinogens; Male; Methylnitronitrosoguanidine; Phenobarbital; Rat	1984
Cocarcinogenic action of aspirin on gastric tumors induced by N-nitroso-N-methylnitroguanidine in rats. Journal of the National Cancer Institute, 1983, Volume: 70, Issue:6 Topics: Adenocarcinoma; Animals; Aspirin; Carcinoma, Squamous Cell; Cocarcinogenesis; Female; Humans; Male;	1983
Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide-induced bladder carcinogenesis and enhancement of forestomach carcinogenesis. Carcinogenesis, 1984, Volume: 5, Issue:1 Topics: Animals; Aspirin; FANFT; Male; Rats; Stomach Neoplasms; Thiazoles; Urinary Bladder Neoplasms	1984
Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate. Cancer, 1984, Mar-01, Volume: 53, Issue:5 Topics: Adenocarcinoma; Animals; Aspirin; Cocarcinogenesis; Diet; Disease Models, Animal; Leiomyosarcoma; Ma	1984
Effect of aspirin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced epithelial proliferation in the urinary bladder and forestomach of the rat. Cancer letters, 1984, Volume: 21, Issue:3 Topics: Animals; Aspirin; Carcinogens; Cell Division; Epithelium; FANFT; Male; Rats; Rats, Inbred F344; Stom	1984
Haematemesis and melaena in the elderly. Age and ageing, 1984, Volume: 13, Issue:1 Topics: Aged; Alcohol Drinking; Anti-Inflammatory Agents; Aspirin; Esophagitis; Female; Gastritis; Hematemes	1984
[Two cases with microangiopathic hemolytic anemia caused by anti-cancer drugs who improved rapidly after administration of aspirin and dipyridamole]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 1982, Volume: 23, Issue:5 Topics: Adult; Aged; Anemia, Hemolytic; Antineoplastic Agents; Aspirin; Chromomycin A3; Dipyridamole; Female	1982
Work in progress. Gastrointestinal ulcerations: detection using a technetium-99m-labeled ulcer-avid agent. Radiology, 1983, Volume: 148, Issue:1 Topics: Aluminum; Animals; Aspirin; Barium Sulfate; Drug Evaluation; Endoscopy; Gastric Mucosa; Humans; Isot	1983
Demonstration of a pH gradient across the mucus layer on the surface of human gastric mucosa in vitro. Gut, 1982, Volume: 23, Issue:6 Topics: Aspirin; Cystine; Gastric Mucosa; Humans; Hydrochloric Acid; Hydrogen-Ion Concentration; In Vitro Te	1982
Effects of eicosanoid metabolism inhibitors on growth of a human gastric tumour cell line (HGT). Cancer letters, 1993, Sep-15, Volume: 73, Issue:1 Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonic Acid; Aspirin; Cell Divisi	1993
Aspirin use and risk of fatal cancer. Cancer research, 1993, Mar-15, Volume: 53, Issue:6 Topics: Acetaminophen; Aspirin; Colonic Neoplasms; Digestive System Neoplasms; Esophageal Neoplasms; Female;	1993
Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1998, Volume: 7, Issue:2 Topics: Adenocarcinoma; Adult; Age Factors; Aged; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal;	1998
Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. British journal of cancer, 1999, Volume: 79, Issue:3-4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blotting, Northern; Blotting, Western;	1999
Aspirin protects against gastric cancer: results of a case-control study from Moscow, Russia. International journal of cancer, 1999, Aug-12, Volume: 82, Issue:4 Topics: Adenocarcinoma; Aged; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carcinoma,	1999
Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability. International journal of cancer, 1999, Aug-20, Volume: 84, Issue:4 Topics: Adaptor Proteins, Signal Transducing; Aspirin; Base Pair Mismatch; Carrier Proteins; Cyclooxygenase	1999
H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells. Gastroenterology, 2000, Volume: 119, Issue:1 Topics: Aspirin; Genes, Dominant; Helicobacter pylori; Humans; I-kappa B Kinase; I-kappa B Proteins; Interle	2000
Risk for gastric cancer after antibiotic prophylaxis in patients undergoing hip replacement. Cancer research, 2000, Nov-15, Volume: 60, Issue:22 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Ant	2000
Aspirin and risk for gastric cancer: a population-based case-control study in Sweden. British journal of cancer, 2001, Apr-06, Volume: 84, Issue:7 Topics: Adenocarcinoma; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies;	2001
Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis, 2001, Volume: 22, Issue:9 Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; bcl-2 Homologous Antagonist-Killer Prot	2001
[Lactate dehydrogenase (LDH) activity of the gastric juice depending on the metabolic state and protective barrier of the gastric mucosa]. Terapevticheskii arkhiv, 1978, Volume: 50, Issue:10 Topics: Adult; Aspirin; Chronic Disease; Duodenal Ulcer; Enzyme Activation; Gastric Juice; Gastric Mucosa; G	1978
Hour-glass stomach: an explanation. The Medical journal of Australia, 1976, Oct-30, Volume: 2, Issue:18 Topics: Adult; Aged; Aspirin; Constriction, Pathologic; Female; Humans; Male; Middle Aged; Sex Factors; Stom	1976
Drug-induced bleeding of gastric leiomyoma. The American journal of gastroenterology, 1987, Volume: 82, Issue:5 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastrointestinal Hemorrhage; Humans;	1987
The management of upper gastro-intestinal tract haemorrhage. The British journal of surgery, 1973, Volume: 60, Issue:4 Topics: Adolescent; Adult; Aged; Aortic Aneurysm; Aspirin; Carcinoma; Duodenal Ulcer; Esophageal and Gastric	1973
Aspirin-induced haemorrhage in gastric leiomyoma. Journal of the Royal College of Surgeons of Edinburgh, 1973, Volume: 18, Issue:4 Topics: Adult; Aspirin; Gastrointestinal Hemorrhage; Humans; Leiomyoma; Male; Radiography; Stomach Neoplasms	1973
Cancer and upper gastrointestinal tract hemorrhage. Benign causes of bleeding demonstrated by endoscopy. JAMA, 1973, Oct-08, Volume: 226, Issue:2 Topics: Acute Disease; Adenocarcinoma; Aspirin; Chronic Disease; Endoscopy; Esophageal and Gastric Varices;	1973
Pyloric stenosis. A different approach to management. The Medical journal of Australia, 1973, Oct-27, Volume: 2, Issue:17 Topics: Adult; Age Factors; Aged; Animals; Ascorbic Acid; Aspirin; Diet Therapy; Drainage; Female; Humans; I	1973
Gastro-intestinal bleeding: the role of vitamin C. Australasian annals of medicine, 1969, Volume: 18, Issue:3 Topics: Ascorbic Acid Deficiency; Aspirin; Feeding Behavior; Gastrointestinal Hemorrhage; Hernia, Diaphragma	1969
[Apropos of 135 cases of massive gastroduodenal hemorrhage (portal hypertension excluded)]. Annales de chirurgie, 1968, Volume: 22, Issue:5 Topics: Adult; Aged; Anticoagulants; Aspirin; Cortisone; Endoscopy; Female; Gastritis; Gastrointestinal Hemo	1968
Gastric ulcer, duodenal ulcer and gastric carcinoma: a case-control study of certain social and environmental factors. The Medical journal of Australia, 1968, Dec-21, Volume: 2, Issue:25 Topics: Adult; Aged; Alcohol Drinking; Aspirin; Australia; Divorce; Duodenal Ulcer; Educational Status; Fami	1968
[Pseudoneoplastic appearance of ulcer of medicamentous origin. Cure of hiatal hernia associated with the medical treatment]. Revue medicale de Liege, 1968, Nov-01, Volume: 23, Issue:21 Topics: Aspirin; Diagnosis, Differential; Female; Hernia, Diaphragmatic; Humans; Peptic Ulcer; Radiography;	1968

aspirin and Cancer of Stomach

Research Excerpts

Research

Studies (118)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Seo, SI	1
Park, CH	1
Kim, TJ	1
Bang, CS	1
Kim, JY	1
Lee, KJ	1
Kim, J	2
Kim, HH	1
You, SC	1
Shin, WG	2
Kwon, S	1
Ma, W	2
Drew, DA	1
Klempner, SJ	1
Leonardo, BM	1
Flynn, JJ	1
Cao, Y	1
Giovannucci, EL	1
Bao, Y	1
Fuchs, CS	1
Song, M	1
Chan, AT	2
Holmberg, D	1
Kauppila, JH	1
Mattsson, F	1
Asplund, J	1
Leijonmarck, W	1
Xie, SH	2
Lagergren, J	3
Umar, A	1
Loomans-Kropp, HA	1
Lai, SW	1
Hwang, BF	1
Liu, CS	1
Liao, KF	1
Ling, X	1
Lin, R	1
Chen, Y	2
Nie, C	1
Sheng, L	1
Liu, J	1
Han, C	1
Ding, Z	1
Miura, Y	1
Tsuji, Y	2
Yoshio, T	2
Hatta, W	2
Yabuuchi, Y	2
Hoteya, S	2
Kikuchi, D	1
Tsuji, S	2
Nagami, Y	2
Hikichi, T	2
Kobayashi, M	2
Morita, Y	2
Sumiyoshi, T	2
Iguchi, M	2
Tomida, H	2
Inoue, T	2
Mikami, T	2
Hasatani, K	2
Nishikawa, J	2
Matsumura, T	4
Nebiki, H	2
Nakamatsu, D	2
Ohnita, K	2
Suzuki, H	2
Ueyama, H	2
Hayashi, Y	3
Sugimoto, M	2
Yamaguchi, S	2
Michida, T	2
Yada, T	2
Asahina, Y	2
Narasaka, T	2
Kuribayashi, S	2
Kiyotoki, S	2
Mabe, K	2
Masamune, A	2
Fujishiro, M	2
Acuna, N	1
Park, SY	1
Le Marchand, L	1
Hébert, JR	1
Boushey, C	1
Wilkens, LR	2
Wu, AH	1
Setiawan, VW	1
Gingold-Belfer, R	1
Issa, N	1
Boltin, D	1
Beloosesky, Y	1
Koren-Morag, N	1
Meyerovitch, J	1
Sharon, E	1
Peleg, N	1
Schmilovitz-Weiss, H	1
Watari, J	3
Ito, C	2
Shimoda, T	1
Tomita, T	3
Oshima, T	4
Fukui, H	3
Das, KM	2
Miwa, H	4
Joharatnam-Hogan, N	1
Cafferty, F	1
Hubner, R	1
Swinson, D	1
Sothi, S	1
Gupta, K	1
Falk, S	1
Patel, K	1
Warner, N	1
Kunene, V	1
Rowley, S	2
Khabra, K	1
Underwood, T	1
Jankowski, J	1
Bridgewater, J	1
Crossley, A	1
Henson, V	1
Berkman, L	2
Gilbert, D	2
Kynaston, H	2
Ring, A	2
Cameron, D	2
Din, F	1
Graham, J	1
Iveson, T	1
Adams, R	1
Thomas, A	1
Wilson, R	1
Pramesh, CS	2
Langley, R	1
Tozawa, K	2
Zheng, J	1
Santoni, G	1
Oura, H	1
Kawasaki, Y	1
Okimoto, K	2
Ishikawa, K	1
Kaneko, T	1
Tokunaga, M	1
Oike, T	1
Imai, Y	1
Yokoyama, Y	1
Akizue, N	1
Maruoka, D	2
Ohta, Y	1
Saito, K	2
Nakagawa, T	2
Arai, M	2
Kato, J	1
Kato, N	1
García Rodríguez, LA	1
Soriano-Gabarró, M	1
Vora, P	1
Cea Soriano, L	1
Meiser, B	1
Kaur, R	1
Kirk, J	1
Morrow, A	1
Peate, M	1
Wong, WKT	1
McPike, E	1
Cops, E	1
Dowson, C	1
Austin, R	1
Fine, M	1
Thrupp, L	1
Ward, R	1
Macrae, F	1
Hiller, JE	1
Trainer, AH	1
Mitchell, G	1
Win, TT	1
Aye, SN	1
Lau Chui Fern, J	1
Ong Fei, C	1
Hamada, K	1
Kanzaki, H	1
Inoue, M	1
Ishiyama, S	1
Yamauchi, K	1
Miyahara, K	1
Toyokawa, T	1
Tsuzuki, T	1
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