aspirin has been researched along with Cancer of Rectum in 36 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the relation between the use of aspirin and non-steroidal anti-inflammatory drugs and the presence of asymptomatic colorectal adenomas." | 9.07 | Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme. ( Hardcastle, JD; Hawtin, PG; Little, J; Logan, RF, 1993) |
| "Most data suggest that the regular use of aspirin reduces the risk of colorectal cancer, but some apparently conflicting evidence exists." | 7.69 | Aspirin and the risk of colorectal cancer in women. ( Colditz, GA; Egan, KM; Giovannucci, E; Hunter, DJ; Speizer, FE; Stampfer, MJ; Willett, WC, 1995) |
| "311 subjects with single/multiple colorectal adenomas and adenocarcinomas excised by endoscopy were enrolled in the study (152 patients in the aspirin group and 159 patients in the placebo group)." | 5.19 | The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: a randomised trial. ( Abe, T; Gondo, N; Goto, C; Iimuro, M; Ishikawa, H; Joh, T; Kitamura, S; Kudo, SE; Kusunoki, M; Lee, K; Matsuda, T; Matsuura, N; Mizuno, M; Mutoh, M; Okamura, S; Saida, Y; Sakai, T; Sano, Y; Sato, Y; Sugimoto, K; Suzuki, S; Tajika, M; Takayama, T; Tanaka, S; Tokudome, S; Wakabayashi, K; Yukawa, T, 2014) |
| "To examine the relation between the use of aspirin and non-steroidal anti-inflammatory drugs and the presence of asymptomatic colorectal adenomas." | 5.07 | Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme. ( Hardcastle, JD; Hawtin, PG; Little, J; Logan, RF, 1993) |
| "In rodents, nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin inhibit chemically induced adenomas and early carcinomas of the colon." | 4.79 | Aspirin and gastrointestinal cancer. ( Thun, MJ, 1997) |
| "Most data suggest that the regular use of aspirin reduces the risk of colorectal cancer, but some apparently conflicting evidence exists." | 3.69 | Aspirin and the risk of colorectal cancer in women. ( Colditz, GA; Egan, KM; Giovannucci, E; Hunter, DJ; Speizer, FE; Stampfer, MJ; Willett, WC, 1995) |
| " Aspirin at conventional dosage is ineffective in preventing the appearance of metastases in patients with colo-rectal cancer." | 2.65 | Adjuvant antiplatelet therapy with aspirin in colo-rectal cancer. ( Dixon, R; Gordon, R; Hamilton, R; Harvey, H; Heckard, R; Lipton, A; Ramsey, H; Scialla, S; Weltz, M; White, D, 1982) |
| "Metformin use was associated with a significantly higher overall and disease-free survival, in a subset of diabetic patients." | 2.55 | Potentiating the effects of radiotherapy in rectal cancer: the role of aspirin, statins and metformin as adjuncts to therapy. ( Chambers, AC; Cotton, DE; Gash, KJ; Thomas, MG; Williams, AC, 2017) |
| "Antibiotics may alter colorectal cancer (CRC) risk due to gut dysbiosis." | 1.72 | Association between antibiotic consumption and colon and rectal cancer development in older individuals: A territory-wide study. ( Chan, EW; Cheung, KS; Hung, IFN; Leung, WK; Seto, WK; Tam, A; Wong, ICK; Wong, IOL, 2022) |
| "Aspirin use was associated with a higher rate of tumour downstaging (67." | 1.42 | Aspirin as a neoadjuvant agent during preoperative chemoradiation for rectal cancer. ( Cabras, F; Casula, G; Cocco, IM; Restivo, A; Scartozzi, M; Scintu, F; Zorcolo, L, 2015) |
| "For both colon and rectal cancer, increasing numbers of risk alleles were associated with increased hazard of death from cancer; the estimated hazard of death for colon cancer for the highest category of risk alleles was 1." | 1.39 | Interleukin genes and associations with colon and rectal cancer risk and overall survival. ( Bondurant, KL; Herrick, JS; Kadlubar, S; Lundgreen, A; Slattery, ML; Wolff, RK, 2013) |
| "Aspirin/NSAID use was classified as none, prediagnosis and postdiagnosis and only postdiagnosis." | 1.38 | Use of aspirin postdiagnosis improves survival for colon cancer patients. ( Bastiaannet, E; Coebergh, JW; de Craen, AJ; Dekkers, OM; Fodde, R; Herings, RM; Lemmens, V; Liefers, GJ; Sampieri, K; van de Velde, CJ; van den Broek, CB; van Herk-Sukel, MP, 2012) |
| "Two SNPs in TXNRD3 were associated with rectal cancer (rs11718498 dominant OR 1." | 1.38 | Genetic variation in selenoprotein genes, lifestyle, and risk of colon and rectal cancer. ( Corcoran, C; Lundgreen, A; Slattery, ML; Welbourn, B; Wolff, RK, 2012) |
| "A population-based study of 750 rectal cancer cases with interview and tumor DNA were compared to 1,205 population-based controls." | 1.35 | Tumor markers and rectal cancer: support for an inflammation-related pathway. ( Caan, BJ; Herrick, J; Samowitz, W; Slattery, ML; Wolff, RK, 2009) |
| "Data were available from 1,577 cases of colon cancer that were matched to 1,971 population-based controls and 794 cases of rectal cancer that were matched to 1,001 population-based controls." | 1.33 | PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States). ( Curtin, K; Levin, TR; Ma, KN; Murtaugh, M; Potter, JD; Samowitz, W; Slattery, ML; Sweeney, C; Wolff, R, 2006) |
| "Variant CYP2C9 genotypes enhanced the protective effect of ibuprofen on the prevention of colorectal cancer, and a dose-response relationship with respect to increasing numbers of variant alleles was seen (P interaction = ." | 1.33 | Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention. ( Andersen, K; Curtin, K; Levin, TR; Ma, KN; Samowitz, WS; Slattery, ML; Sweeney, C; Wolff, RK, 2006) |
| "For proximal colon cancer, the multivariable-adjusted HRs for women reporting use of aspirin or non-aspirin NSAIDs two or more times weekly (compared with nonusers of each) were 0." | 1.33 | Nonsteroidal anti-inflammatory drugs and subsite-specific colorectal cancer incidence in the Iowa women's health study. ( Anderson, KE; Folsom, AR; Limburg, PJ; Mahipal, A, 2006) |
| "Aspirin was the most prospective chemopreventive agents for colorectal polyp, colon and rectal carcinoma for its capability of reducing the risk of cardio-cerebral vascular disease as well." | 1.31 | [Nonsteroidal anti-inflammatory drugs and the risk of polyposis, colon carcinoma and rectal carcinoma]. ( Gao, X; Li, M; Song, S; Sun, F; Sun, H; Sun, S; Zhang, W, 2002) |
| "Treatment of colorectal cancers is based on surgery and the prognosis is determined by the locoregional or metastatic tumor spread." | 1.30 | [How I treat colorectal cancer. I. Prevention and adjuvant treatment]. ( Bours, V; Fillet, G; Jerusalem, G, 1998) |
| "Colorectal cancer is the second leading cause of death from cancer in The United States." | 1.30 | Colorectal cancer--chemoprevention. ( Boone, WT, 1998) |
| "We have reported reduced risk of fatal colon cancer among persons who used aspirin in a large prospective study." | 1.29 | Aspirin use and risk of fatal cancer. ( Calle, EE; Flanders, WD; Heath, CW; Namboodiri, MM; Thun, MJ, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.33) | 18.7374 |
| 1990's | 11 (30.56) | 18.2507 |
| 2000's | 10 (27.78) | 29.6817 |
| 2010's | 10 (27.78) | 24.3611 |
| 2020's | 2 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Cheung, KS | 1 |
| Chan, EW | 1 |
| Tam, A | 1 |
| Wong, IOL | 1 |
| Seto, WK | 1 |
| Hung, IFN | 1 |
| Wong, ICK | 1 |
| Leung, WK | 1 |
| Wang, B | 1 |
| Huang, Y | 1 |
| Gash, KJ | 1 |
| Chambers, AC | 1 |
| Cotton, DE | 1 |
| Williams, AC | 1 |
| Thomas, MG | 1 |
| Ishikawa, H | 1 |
| Mutoh, M | 1 |
| Suzuki, S | 1 |
| Tokudome, S | 1 |
| Saida, Y | 1 |
| Abe, T | 1 |
| Okamura, S | 1 |
| Tajika, M | 1 |
| Joh, T | 1 |
| Tanaka, S | 1 |
| Kudo, SE | 1 |
| Matsuda, T | 1 |
| Iimuro, M | 1 |
| Yukawa, T | 1 |
| Takayama, T | 1 |
| Sato, Y | 1 |
| Lee, K | 1 |
| Kitamura, S | 1 |
| Mizuno, M | 1 |
| Sano, Y | 1 |
| Gondo, N | 1 |
| Sugimoto, K | 1 |
| Kusunoki, M | 1 |
| Goto, C | 1 |
| Matsuura, N | 1 |
| Sakai, T | 1 |
| Wakabayashi, K | 1 |
| Sung, JJ | 1 |
| Restivo, A | 1 |
| Cocco, IM | 1 |
| Casula, G | 1 |
| Scintu, F | 1 |
| Cabras, F | 1 |
| Scartozzi, M | 1 |
| Zorcolo, L | 1 |
| Hardie, C | 1 |
| Jung, Y | 1 |
| Jameson, M | 1 |
| Slattery, ML | 7 |
| Wolff, RK | 6 |
| Herrick, J | 1 |
| Caan, BJ | 2 |
| Samowitz, W | 2 |
| Bastiaannet, E | 1 |
| Sampieri, K | 1 |
| Dekkers, OM | 1 |
| de Craen, AJ | 1 |
| van Herk-Sukel, MP | 1 |
| Lemmens, V | 1 |
| van den Broek, CB | 1 |
| Coebergh, JW | 1 |
| Herings, RM | 1 |
| van de Velde, CJ | 1 |
| Fodde, R | 1 |
| Liefers, GJ | 1 |
| Lundgreen, A | 3 |
| Welbourn, B | 2 |
| Corcoran, C | 2 |
| Pigot, F | 1 |
| Juguet, F | 1 |
| Bouchard, D | 1 |
| Castinel, A | 1 |
| Bondurant, KL | 1 |
| Herrick, JS | 2 |
| Kadlubar, S | 1 |
| Gao, X | 1 |
| Sun, S | 1 |
| Sun, F | 1 |
| Li, M | 1 |
| Sun, H | 1 |
| Zhang, W | 1 |
| Song, S | 1 |
| Lotufo, PA | 1 |
| BANNERMAN, RM | 1 |
| BEVERIDGE, BR | 1 |
| WITTS, LJ | 1 |
| Katz, MS | 1 |
| Minsky, BD | 1 |
| Saltz, LB | 1 |
| Riedel, E | 1 |
| Chessin, DB | 1 |
| Guillem, JG | 1 |
| Curtin, K | 2 |
| Wolff, R | 1 |
| Ma, KN | 2 |
| Sweeney, C | 2 |
| Murtaugh, M | 1 |
| Potter, JD | 2 |
| Levin, TR | 2 |
| Samowitz, WS | 1 |
| Andersen, K | 1 |
| Mahipal, A | 1 |
| Anderson, KE | 1 |
| Limburg, PJ | 1 |
| Folsom, AR | 1 |
| Lipton, A | 1 |
| Scialla, S | 1 |
| Harvey, H | 1 |
| Dixon, R | 1 |
| Gordon, R | 1 |
| Hamilton, R | 1 |
| Ramsey, H | 1 |
| Weltz, M | 1 |
| Heckard, R | 1 |
| White, D | 1 |
| Doran, J | 1 |
| Hardcastle, JD | 2 |
| Giovannucci, E | 1 |
| Egan, KM | 1 |
| Hunter, DJ | 1 |
| Stampfer, MJ | 1 |
| Colditz, GA | 1 |
| Willett, WC | 1 |
| Speizer, FE | 1 |
| Farmer, KC | 1 |
| Goulston, K | 1 |
| Macrae, F | 1 |
| Suh, O | 1 |
| Mettlin, C | 1 |
| Petrelli, NJ | 1 |
| Paganini-Hill, A | 1 |
| Logan, RF | 1 |
| Little, J | 1 |
| Hawtin, PG | 1 |
| Thun, MJ | 2 |
| Namboodiri, MM | 1 |
| Calle, EE | 1 |
| Flanders, WD | 1 |
| Heath, CW | 1 |
| Rosenberg, L | 1 |
| Louik, C | 1 |
| Shapiro, S | 1 |
| Bours, V | 1 |
| Jerusalem, G | 1 |
| Fillet, G | 1 |
| Boone, WT | 1 |
| Arber, N | 1 |
| Stark, LA | 1 |
| Din, FV | 1 |
| Zwacka, RM | 1 |
| Dunlop, MG | 1 |
| Ducreux, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevention of Females Malignancies in Families With Hereditary Breast Cancer by Personalized Optimization of Se Levels in the Organism.[NCT04014283] | 7,000 participants (Anticipated) | Interventional | 2014-10-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for aspirin and Cancer of Rectum
| Article | Year |
|---|---|
Effect of aspirin use on neoadjuvant chemoradiotherapy for rectal cancer: a meta-analysis with trial sequential analysis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspirin; Chemoradiotherapy, Adjuvant; Drug Synergism | 2020 |
Potentiating the effects of radiotherapy in rectal cancer: the role of aspirin, statins and metformin as adjuncts to therapy.
Topics: Aspirin; Chemotherapy, Adjuvant; Combined Modality Therapy; Disease-Free Survival; Female; Humans; H | 2017 |
Aspirin and gastrointestinal cancer.
Topics: Adenoma; Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinoge | 1997 |
Do NSAIDs prevent colorectal cancer?
Topics: Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neopl | 2000 |
[Prevention of colorectal cancer: what is the role of aspirin?].
Topics: Aspirin; Colonic Neoplasms; Female; Humans; Male; Rectal Neoplasms | 1992 |
3 trials available for aspirin and Cancer of Rectum
| Article | Year |
|---|---|
The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: a randomised trial.
Topics: Adenocarcinoma; Adenoma; Adult; Aged; Alcohol Drinking; Anticarcinogenic Agents; Aspirin; Colonic Ne | 2014 |
Adjuvant antiplatelet therapy with aspirin in colo-rectal cancer.
Topics: Actuarial Analysis; Adjuvants, Pharmaceutic; Aspirin; Blood Platelets; Colonic Neoplasms; Humans; Pa | 1982 |
Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme.
Topics: Acetaminophen; Adenoma; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies | 1993 |
28 other studies available for aspirin and Cancer of Rectum
| Article | Year |
|---|---|
Association between antibiotic consumption and colon and rectal cancer development in older individuals: A territory-wide study.
Topics: Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonoscopy; Colorect | 2022 |
Is aspirin for colorectal cancer prevention on the prime time yet?
Topics: Adenocarcinoma; Adenoma; Anticarcinogenic Agents; Aspirin; Colonic Neoplasms; Cyclooxygenase Inhibit | 2014 |
Aspirin as a neoadjuvant agent during preoperative chemoradiation for rectal cancer.
Topics: Aged; Antineoplastic Agents; Aspirin; Chemoradiotherapy; Chemotherapy, Adjuvant; Disease-Free Surviv | 2015 |
Effect of statin and aspirin use on toxicity and pathological complete response rate of neo-adjuvant chemoradiation for rectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ch | 2016 |
Tumor markers and rectal cancer: support for an inflammation-related pathway.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Biomarkers, Tumor; Cali | 2009 |
Use of aspirin postdiagnosis improves survival for colon cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; | 2012 |
Oxidative balance and colon and rectal cancer: interaction of lifestyle factors and genes.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; Diet; Female; Gene | 2012 |
Do we have to stop anticoagulant and platelet-inhibitor treatments during proctological surgery?
Topics: Adult; Anticoagulants; Aspirin; Blood Transfusion; Chi-Square Distribution; Clopidogrel; Female; Hem | 2012 |
Genetic variation in selenoprotein genes, lifestyle, and risk of colon and rectal cancer.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Colonic Neoplas | 2012 |
Interleukin genes and associations with colon and rectal cancer risk and overall survival.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers, Tumor; Body Mass Index; C | 2013 |
[Nonsteroidal anti-inflammatory drugs and the risk of polyposis, colon carcinoma and rectal carcinoma].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Female; Humans; Ibupr | 2002 |
The noise stops you from hearing good music: the possibilities for a mortality reduction program for cancer of the colon and rectum in São Paulo.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brazil; Colonic Neoplasms; Cost-Benefit Analysis; | 2003 |
ANAEMIA ASSOCIATED WITH UNEXPLAINED OCCULT BLOOD LOSS.
Topics: Anemia; Anemia, Hypochromic; Aspirin; Diagnosis, Differential; Guaiac; Hemorrhoids; Humans; Iron; Li | 1964 |
Association of statin use with a pathologic complete response to neoadjuvant chemoradiation for rectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Aspir | 2005 |
PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States).
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; California; Case-Control Studies; Col | 2006 |
Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Aspirin; Case-C | 2006 |
Nonsteroidal anti-inflammatory drugs and subsite-specific colorectal cancer incidence in the Iowa women's health study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; Female; Follow-Up Studies | 2006 |
IL6 genotypes and colon and rectal cancer.
Topics: Adult; Aged; Alleles; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; Female; G | 2007 |
Bleeding patterns in colorectal cancer: the effect of aspirin and the implications for faecal occult blood testing.
Topics: Aspirin; Colonic Neoplasms; Feces; Female; Humans; Male; Occult Blood; Rectal Neoplasms | 1982 |
Aspirin and the risk of colorectal cancer in women.
Topics: Adult; Aspirin; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Female; Humans; Middle Aged | 1995 |
Aspirin and non-steroidal anti-inflammatory drugs in the chemoprevention of colorectal cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; Colonic Polyps; Female | 1993 |
Aspirin use, cancer, and polyps of the large bowel.
Topics: Aspirin; Case-Control Studies; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administrat | 1993 |
Aspirin and colorectal cancer.
Topics: Aspirin; Colonic Neoplasms; Humans; Rectal Neoplasms; Risk Factors | 1993 |
Aspirin use and risk of fatal cancer.
Topics: Acetaminophen; Aspirin; Colonic Neoplasms; Digestive System Neoplasms; Esophageal Neoplasms; Female; | 1993 |
Nonsteroidal antiinflammatory drug use and reduced risk of large bowel carcinoma.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Colonic Neoplas | 1998 |
[How I treat colorectal cancer. I. Prevention and adjuvant treatment].
Topics: Adenocarcinoma; Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Antimeta | 1998 |
Colorectal cancer--chemoprevention.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; Folic Acid; Humans; Rectal Neop | 1998 |
Aspirin-induced activation of the NF-kappaB signaling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cells.
Topics: Active Transport, Cell Nucleus; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apop | 2001 |