aspirin has been researched along with Cancer of Pancreas in 73 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin and aspirin have been explored as two emerging cancer chemoprevention agents for different types of cancers, including pancreatic cancer." | 6.50 | Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment. ( DiPaola, RS; Tan, XL; Yang, CS; Yue, W, 2014) |
| "Current available therapies for pancreatic ductal adenocarcinoma (PDAC) provide minimal overall survival benefits and cause severe adverse effects." | 5.62 | Novel Seleno-Aspirinyl Compound AS-10 Induces Apoptosis, G1 Arrest of Pancreatic Ductal Adenocarcinoma Cells, Inhibits Their NF-κB Signaling, and Synergizes with Gemcitabine Cytotoxicity. ( Amin, S; K Pandey, M; Karelia, DN; Kim, S; Lu, J; Plano, D; Sharma, AK, 2021) |
| "Pancreatic cancer is a deadly disease with a dismal 5-year survival rate of <6%." | 5.43 | Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice. ( Bandovic, J; Mackenzie, GG; Mattheolabakis, G; Ouyang, N; Papayannis, I; Rigas, B; Vaeth, BM; Wang, R; Yang, J, 2016) |
| "Aspirin and other NSAIDs are showing promise in the chemoprevention of colorectal cancer." | 4.80 | Non-steroidal anti-inflammatory drugs and chemoprevention of cancer. ( Morgan, G; Vainio, H, 2000) |
| "We evaluated aspirin and non-aspirin NSAID use and risk of pancreatic adenocarcinoma in 141,940 participants from the Health Professionals Follow-up Study and Nurses' Health Study using multivariable-adjusted Cox proportional hazards regression." | 3.88 | Regular Use of Aspirin or Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs Is Not Associated With Risk of Incident Pancreatic Cancer in Two Large Cohort Studies. ( Babic, A; Cao, Y; Chan, AT; Clish, CB; Cochrane, BB; Fuchs, CS; Giovannucci, E; Hamada, T; Khalaf, N; Kraft, P; Manson, JE; Morales-Oyarvide, V; Ng, K; Ogino, S; Stampfer, M; Wolpin, BM; Yuan, C, 2018) |
| " This study explored the effect of the NO-donating aspirin derivative, NCX 4040, on three human pancreatic adenocarcinoma cell lines (Capan-2, MIA PaCa-2 and T3M4)." | 3.73 | Molecular characterization of cytotoxic and resistance mechanisms induced by NCX 4040, a novel NO-NSAID, in pancreatic cancer cell lines. ( Amadori, D; Bolla, M; Brigliadori, G; Fabbri, F; Rosetti, M; Tesei, A; Ulivi, P; Vannini, I; Zoli, W, 2006) |
| "A total of 12 studies involving 4748 pancreatic cancer cases, were included in the meta-analysis." | 2.61 | Aspirin use and pancreatic cancer risk: A systematic review of observational studies. ( Jiang, Z; Li, Y; Liu, G; Liu, L; Sun, J, 2019) |
| "Survival from pancreatic cancer remains poor." | 2.53 | The Role of Common Pharmaceutical Agents on the Prevention and Treatment of Pancreatic Cancer. ( Amin, S; Boffetta, P; Lucas, AL, 2016) |
| "However, the function of aspirin use in pancreatic cancer largely remains unknown." | 2.53 | Aspirin in pancreatic cancer: chemopreventive effects and therapeutic potentials. ( Dai, JJ; Gu, DN; Huang, Q; Jiang, MJ; Tian, L, 2016) |
| "Metformin and aspirin have been explored as two emerging cancer chemoprevention agents for different types of cancers, including pancreatic cancer." | 2.50 | Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment. ( DiPaola, RS; Tan, XL; Yang, CS; Yue, W, 2014) |
| "Inflammation has become a research hotspot in solid tumours and has been confirmed as a key factor in tumour development through the interactions of inflammatory mediators with gene expression, cell proliferation, and apoptosis." | 2.49 | Aspirin: a potential therapeutic approach in pancreatic cancer. ( Chen, C; Duan, W; Han, L; Li, P; Li, W; Ma, Q; Ma, Z; Shen, X; Xu, Q; Yu, S; Zhang, L, 2013) |
| "Pancreatic cancer is the most deadly of all gastrointestinal malignancies with near zero five-year survival." | 2.43 | NF-kappaB, inflammation and pancreatic carcinogenesis: NF-kappaB as a chemoprevention target (review). ( Rigas, B; Zhang, Z, 2006) |
| "In the United States, pancreatic cancer is the 4(th) leading cause of cancer death, and in Europe it is the 6th." | 2.42 | Epidemiology of pancreatic cancer. ( Michaud, DS, 2004) |
| "Current available therapies for pancreatic ductal adenocarcinoma (PDAC) provide minimal overall survival benefits and cause severe adverse effects." | 1.62 | Novel Seleno-Aspirinyl Compound AS-10 Induces Apoptosis, G1 Arrest of Pancreatic Ductal Adenocarcinoma Cells, Inhibits Their NF-κB Signaling, and Synergizes with Gemcitabine Cytotoxicity. ( Amin, S; K Pandey, M; Karelia, DN; Kim, S; Lu, J; Plano, D; Sharma, AK, 2021) |
| "For our study, we used two colon cancer cell lines isolated from the same donor but characterized by different metastatic potential, SW480 (nonmetastatic) and SW620 (metastatic) cancer cells, and a pancreatic cancer cell line, PANC-1 (nonmetastatic)." | 1.46 | Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC. ( McCarty, OJ; Mitrugno, A; Ngo, AT; Pang, J; Sears, RC; Sylman, JL; Williams, CD, 2017) |
| "Gemcitabine was used for chemotherapy." | 1.43 | Atorvastatin (Lipitor) attenuates the effects of aspirin on pancreatic cancerogenesis and the chemotherapeutic efficacy of gemcitabine on pancreatic cancer by promoting M2 polarized tumor associated macrophages. ( Li, Y; Liao, Q; Liu, Q; Lu, Z; Niu, Z; Wang, M; Yao, L; Zhao, Y; Zong, Y, 2016) |
| "Pancreatic cancer is a deadly disease with a dismal 5-year survival rate of <6%." | 1.43 | Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice. ( Bandovic, J; Mackenzie, GG; Mattheolabakis, G; Ouyang, N; Papayannis, I; Rigas, B; Vaeth, BM; Wang, R; Yang, J, 2016) |
| "We used data from the Queensland Pancreatic Cancer Study, a population-based case-control study." | 1.43 | Nonsteroidal anti-inflammatory drugs, statins, and pancreatic cancer risk: a population-based case-control study. ( Fawcett, J; Fritschi, L; Kho, PF; Neale, RE; Risch, H; Webb, PM; Whiteman, DC, 2016) |
| "Metformin and aspirin have been studied extensively as cancer preventive or therapeutic agents." | 1.42 | Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. ( Carpizo, D; DiPaola, RS; Huang, H; Lin, Y; Tan, XL; Xu, Q; Yang, CS; Yue, W; Zheng, X, 2015) |
| "Metformin and aspirin have been studied extensively as cancer preventative and therapeutic agents." | 1.42 | Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy. ( DiPaola, RS; Lin, Y; Tan, XL; Wang, T; Xu, Q; Yang, CS; Yue, W; Zachariah, E, 2015) |
| "Increments of decreasing risk of pancreatic cancer were observed for each year of low-dose or regular-dose aspirin use (OR, 0." | 1.40 | Case-control study of aspirin use and risk of pancreatic cancer. ( Kidd, MS; Lu, L; Risch, HA; Streicher, SA; Yu, H, 2014) |
| "Treatment with aspirin suppressed the viability/proliferation of BON1, NCI-H727 and GOT1 cells in a time- and dose-dependent manner." | 1.40 | Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells. ( Auernhammer, CJ; Göke, B; Maurer, J; Spampatti, M; Spöttl, G; Vlotides, G, 2014) |
| "Pancreatic cancer is a deadly disease killing 37,000 Americans each year." | 1.39 | A novel combinatorial nanotechnology-based oral chemopreventive regimen demonstrates significant suppression of pancreatic cancer neoplastic lesions. ( Grandhi, BK; Prabhu, S; Thakkar, A; Wang, J, 2013) |
| "Pancreatic cancer is the fourth largest cause of cancer deaths in the Unites States and the prognosis is grim with <5% survival chances upon diagnosis." | 1.38 | Chemoprevention of pancreatic cancer using solid-lipid nanoparticulate delivery of a novel aspirin, curcumin and sulforaphane drug combination regimen. ( Grandhi, BK; Prabhu, S; Sutaria, D; Thakkar, A; Wang, J, 2012) |
| "Invasive pancreatic cancer was identified in 15 of 25 (60%) LsL-Kras(G12D); LsL-Trp53(R172H); Pdx1-Cre untreated control mice, but in only three of 17 (17." | 1.36 | The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer. ( Bartsch, DK; Buchholz, M; Chen, NM; Feldmann, G; Fendrich, V; Maitra, A; Neef, M; Slater, EP; Waldmann, J, 2010) |
| "Two gemcitabine-insensitive human pancreatic cancer cell lines, PANC-1 and Capan-1, were used." | 1.36 | Aspirin inhibits proliferation of gemcitabine-resistant human pancreatic cancer cells and augments gemcitabine-induced cytotoxicity. ( He, SM; Huang, YJ; Leng, TD; Li, Y; Ou, YQ; Qiu, PX; Xie, J; Xu, D; Yan, GM; Zheng, XK; Zhu, Wb, 2010) |
| "The role of aspirin use in pancreatic cancer is further analyzed in a multicentric hospital-based case-control study conducted in Italy between 1991 and 2008." | 1.36 | Aspirin use and pancreatic cancer risk. ( Bonifazi, M; Bosetti, C; Gallus, S; La Vecchia, C; Negri, E; Polesel, J; Serraino, D; Talamini, R, 2010) |
| "Aspirin has been proposed as a possible chemopreventive agent." | 1.35 | Damage to cellular and isolated DNA induced by a metabolite of aspirin. ( Isono, Y; Kawanishi, S; Kobayashi, H; Oikawa, S; Tada-Oikawa, S, 2009) |
| "Thus, NO-ASA profoundly prevented pancreatic cancer and modulated multiple molecular targets in this model system; conventional ASA had no such effects." | 1.33 | Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model. ( Gao, J; Iatropoulos, MJ; Kashfi, K; Kopelovich, L; Ouyang, N; Rigas, B; Tsioulias, GJ; Williams, JL, 2006) |
| "Aspirin use was first assessed at baseline in 1980 and updated biennially thereafter." | 1.32 | A prospective study of aspirin use and the risk of pancreatic cancer in women. ( Chan, AT; Colditz, GA; Fuchs, CS; Giovannucci, E; Kang, JH; Michaud, DS; Schernhammer, ES; Skinner, HG, 2004) |
| "Aspirin use was not associated with pancreatic cancer mortality." | 1.32 | Aspirin use and pancreatic cancer mortality in a large United States cohort. ( Calle, EE; Connell, CJ; Jacobs, EJ; Patel, AV; Rodriguez, C; Thun, MJ, 2004) |
| "Nonaspirin NSAID use was not associated with incident pancreatic cancer." | 1.31 | Association between nonsteroidal anti-inflammatory drug use and the incidence of pancreatic cancer. ( Anderson, KE; Folsom, AR; Johnson, TW; Lazovich, D, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.74) | 18.7374 |
| 1990's | 2 (2.74) | 18.2507 |
| 2000's | 21 (28.77) | 29.6817 |
| 2010's | 43 (58.90) | 24.3611 |
| 2020's | 5 (6.85) | 2.80 |
| Authors | Studies |
|---|---|
| Rodriguez Lanzi, C | 1 |
| Wei, R | 1 |
| Luo, D | 1 |
| Mackenzie, GG | 2 |
| Zaccari, P | 1 |
| Archibugi, L | 2 |
| Belfiori, G | 1 |
| Nista, E | 1 |
| dell'Anna, G | 1 |
| Crippa, S | 1 |
| Schepis, T | 1 |
| Tacelli, M | 1 |
| Aleotti, F | 1 |
| Petrone, MC | 1 |
| Mariani, A | 1 |
| Costamagna, G | 1 |
| Gasbarrini, A | 1 |
| Larghi, A | 1 |
| Falconi, M | 1 |
| Arcidiacono, PG | 1 |
| Capurso, G | 2 |
| Bassani-Sternberg, M | 1 |
| Digklia, A | 1 |
| Huber, F | 1 |
| Wagner, D | 1 |
| Sempoux, C | 1 |
| Stevenson, BJ | 1 |
| Thierry, AC | 1 |
| Michaux, J | 1 |
| Pak, H | 1 |
| Racle, J | 1 |
| Boudousquie, C | 1 |
| Balint, K | 1 |
| Coukos, G | 1 |
| Gfeller, D | 1 |
| Martin Lluesma, S | 1 |
| Harari, A | 1 |
| Demartines, N | 1 |
| Kandalaft, LE | 1 |
| Cavalcoli, F | 1 |
| Pusceddu, S | 1 |
| Zilli, A | 1 |
| Tamagno, G | 1 |
| Femia, D | 1 |
| Prinzi, N | 1 |
| Travers, J | 1 |
| Consonni, D | 1 |
| Ciafardini, C | 1 |
| Conte, D | 1 |
| Massironi, S | 1 |
| Choi, JH | 1 |
| Lee, SH | 1 |
| Huh, G | 1 |
| Chun, JW | 1 |
| You, MS | 1 |
| Paik, WH | 1 |
| Ryu, JK | 1 |
| Kim, YT | 1 |
| Sun, J | 1 |
| Li, Y | 3 |
| Liu, L | 2 |
| Jiang, Z | 1 |
| Liu, G | 1 |
| Khoudari, G | 1 |
| Alkhayyat, M | 1 |
| Abou Saleh, M | 1 |
| Mansoor, E | 1 |
| Sarmini, MT | 1 |
| Baidoun, F | 1 |
| Vega, KJ | 1 |
| Sanaka, MR | 1 |
| Pretzsch, E | 1 |
| D'Haese, JG | 1 |
| Renz, B | 1 |
| Ilmer, M | 1 |
| Schiergens, T | 1 |
| Miksch, RC | 1 |
| Albertsmeier, M | 1 |
| Guba, M | 1 |
| Angele, MK | 1 |
| Werner, J | 1 |
| Nieß, H | 1 |
| Karelia, DN | 1 |
| Kim, S | 1 |
| K Pandey, M | 1 |
| Plano, D | 1 |
| Amin, S | 2 |
| Lu, J | 1 |
| Sharma, AK | 1 |
| Risch, HA | 4 |
| Mormile, R | 1 |
| Brasky, TM | 1 |
| Wactawski-Wende, J | 1 |
| Piciucchi, M | 1 |
| Stigliano, S | 1 |
| Valente, R | 1 |
| Zerboni, G | 1 |
| Barucca, V | 1 |
| Milella, M | 1 |
| Maisonneuve, P | 1 |
| Delle Fave, G | 1 |
| Khalaf, N | 1 |
| Yuan, C | 1 |
| Hamada, T | 1 |
| Cao, Y | 1 |
| Babic, A | 1 |
| Morales-Oyarvide, V | 1 |
| Kraft, P | 1 |
| Ng, K | 1 |
| Giovannucci, E | 3 |
| Ogino, S | 1 |
| Stampfer, M | 1 |
| Cochrane, BB | 1 |
| Manson, JE | 1 |
| Clish, CB | 1 |
| Chan, AT | 2 |
| Fuchs, CS | 2 |
| Wolpin, BM | 1 |
| Dickson, I | 1 |
| Manoharan, J | 1 |
| Fendrich, V | 3 |
| Di Fazio, P | 1 |
| Bollmann, C | 1 |
| Roth, S | 1 |
| Joos, B | 1 |
| Mintziras, I | 1 |
| Albers, MB | 1 |
| Ramaswamy, A | 1 |
| Bertolino, P | 1 |
| Zhang, CX | 1 |
| Slater, EP | 2 |
| Bartsch, DK | 3 |
| Lopez-Lopez, CL | 1 |
| Kim, MH | 1 |
| Park, SM | 1 |
| Yun, YH | 1 |
| Hwang, IC | 1 |
| Mensah, ET | 1 |
| Smyrk, T | 1 |
| Zhang, L | 2 |
| Bick, B | 1 |
| Wood-Wentz, CM | 1 |
| Buttar, N | 1 |
| Chari, ST | 1 |
| Gleeson, FC | 1 |
| Kendrick, M | 1 |
| Levy, M | 1 |
| Pearson, R | 1 |
| Petersen, BT | 1 |
| Vege, S | 1 |
| Enders, F | 1 |
| Limburg, P | 1 |
| Topazian, M | 1 |
| Thakkar, A | 3 |
| Sutaria, D | 2 |
| Grandhi, BK | 3 |
| Wang, J | 4 |
| Prabhu, S | 3 |
| Shen, X | 1 |
| Han, L | 1 |
| Ma, Z | 1 |
| Chen, C | 1 |
| Duan, W | 1 |
| Yu, S | 1 |
| Li, P | 1 |
| Li, W | 1 |
| Xu, Q | 3 |
| Ma, Q | 1 |
| Plassmeier, L | 1 |
| Knoop, R | 1 |
| Waldmann, J | 2 |
| Kesselring, R | 1 |
| Buchholz, M | 2 |
| Fichtner-Feigl, S | 1 |
| Cui, XJ | 1 |
| He, Q | 1 |
| Zhang, JM | 1 |
| Fan, HJ | 1 |
| Wen, ZF | 1 |
| Qin, YR | 1 |
| Yue, W | 3 |
| Yang, CS | 3 |
| DiPaola, RS | 3 |
| Tan, XL | 4 |
| Streicher, SA | 2 |
| Yu, H | 2 |
| Lu, L | 2 |
| Kidd, MS | 2 |
| Spampatti, M | 1 |
| Vlotides, G | 1 |
| Spöttl, G | 1 |
| Maurer, J | 1 |
| Göke, B | 1 |
| Auernhammer, CJ | 1 |
| McAllister, F | 1 |
| Leach, SD | 1 |
| Zhang, Y | 1 |
| Fan, P | 1 |
| Bauer, N | 1 |
| Gladkich, J | 1 |
| Ryschich, E | 1 |
| Bazhin, AV | 1 |
| Giese, NA | 1 |
| Strobel, O | 1 |
| Hackert, T | 1 |
| Hinz, U | 1 |
| Gross, W | 1 |
| Fortunato, F | 1 |
| Herr, I | 1 |
| Zheng, X | 1 |
| Lin, Y | 2 |
| Carpizo, D | 1 |
| Huang, H | 1 |
| Wang, T | 1 |
| Zachariah, E | 1 |
| Zhang, YP | 1 |
| Wan, YD | 1 |
| Sun, YL | 1 |
| Li, J | 1 |
| Zhu, RT | 1 |
| Liu, Q | 1 |
| Niu, Z | 1 |
| Zong, Y | 1 |
| Wang, M | 1 |
| Yao, L | 1 |
| Lu, Z | 1 |
| Liao, Q | 1 |
| Zhao, Y | 1 |
| Mattheolabakis, G | 1 |
| Papayannis, I | 1 |
| Yang, J | 1 |
| Vaeth, BM | 1 |
| Wang, R | 1 |
| Bandovic, J | 1 |
| Ouyang, N | 2 |
| Rigas, B | 6 |
| Boffetta, P | 1 |
| Lucas, AL | 1 |
| Jiang, MJ | 1 |
| Dai, JJ | 1 |
| Gu, DN | 1 |
| Huang, Q | 1 |
| Tian, L | 1 |
| Vaughan, LE | 1 |
| Prizment, A | 1 |
| Blair, CK | 1 |
| Thomas, W | 1 |
| Anderson, KE | 3 |
| Kho, PF | 1 |
| Fawcett, J | 1 |
| Fritschi, L | 1 |
| Risch, H | 1 |
| Webb, PM | 1 |
| Whiteman, DC | 1 |
| Neale, RE | 1 |
| Mitrugno, A | 1 |
| Sylman, JL | 1 |
| Ngo, AT | 1 |
| Pang, J | 1 |
| Sears, RC | 1 |
| Williams, CD | 1 |
| McCarty, OJ | 1 |
| Zhang, W | 1 |
| Ni, Q | 1 |
| Gao, YT | 1 |
| Zhou, H | 1 |
| Huang, L | 1 |
| Sun, Y | 1 |
| Oikawa, S | 1 |
| Kobayashi, H | 1 |
| Tada-Oikawa, S | 1 |
| Isono, Y | 1 |
| Kawanishi, S | 1 |
| Chen, NM | 1 |
| Neef, M | 1 |
| Feldmann, G | 1 |
| Maitra, A | 1 |
| Ou, YQ | 1 |
| Zhu, Wb | 1 |
| Qiu, PX | 1 |
| Huang, YJ | 1 |
| Xie, J | 1 |
| He, SM | 1 |
| Zheng, XK | 1 |
| Leng, TD | 1 |
| Xu, D | 1 |
| Yan, GM | 1 |
| Hawk, E | 1 |
| Patterson, S | 1 |
| Bonifazi, M | 1 |
| Gallus, S | 1 |
| Bosetti, C | 1 |
| Polesel, J | 1 |
| Serraino, D | 1 |
| Talamini, R | 1 |
| Negri, E | 1 |
| La Vecchia, C | 1 |
| Reid Lombardo, KM | 1 |
| Bamlet, WR | 1 |
| Oberg, AL | 1 |
| Robinson, DP | 1 |
| Petersen, GM | 1 |
| Rao, CV | 1 |
| Mohammed, A | 1 |
| Janakiram, NB | 1 |
| Li, Q | 1 |
| Ritchie, RL | 1 |
| Lightfoot, S | 1 |
| Vibhudutta, A | 1 |
| Steele, VE | 1 |
| Yıldız, H | 1 |
| Oztas, H | 1 |
| Yıldız, D | 1 |
| Koc, A | 1 |
| Kalipci, E | 1 |
| Johnson, TW | 1 |
| Lazovich, D | 1 |
| Folsom, AR | 1 |
| Menezes, RJ | 1 |
| Huber, KR | 1 |
| Mahoney, MC | 1 |
| Moysich, KB | 1 |
| Hitt, E | 1 |
| Baron, JA | 1 |
| Schernhammer, ES | 1 |
| Kang, JH | 1 |
| Michaud, DS | 2 |
| Skinner, HG | 1 |
| Colditz, GA | 1 |
| Jacobs, EJ | 1 |
| Connell, CJ | 1 |
| Rodriguez, C | 1 |
| Patel, AV | 1 |
| Calle, EE | 1 |
| Thun, MJ | 1 |
| Gensini, GF | 1 |
| Conti, AA | 1 |
| Abbate, R | 1 |
| Sclabas, GM | 1 |
| Uwagawa, T | 1 |
| Schmidt, C | 1 |
| Hess, KR | 1 |
| Evans, DB | 1 |
| Abbruzzese, JL | 1 |
| Chiao, PJ | 1 |
| Kashfi, K | 2 |
| Williams, JL | 1 |
| Tsioulias, GJ | 1 |
| Gao, J | 1 |
| Iatropoulos, MJ | 1 |
| Kopelovich, L | 1 |
| Iconomou, G | 1 |
| Kalofonos, HP | 1 |
| Koutras, AK | 1 |
| Vagenakis, AG | 1 |
| Rosetti, M | 1 |
| Tesei, A | 1 |
| Ulivi, P | 1 |
| Fabbri, F | 1 |
| Vannini, I | 1 |
| Brigliadori, G | 1 |
| Amadori, D | 1 |
| Bolla, M | 1 |
| Zoli, W | 1 |
| Zhang, Z | 1 |
| Larsson, SC | 1 |
| Bergkvist, L | 1 |
| Wolk, A | 1 |
| Robles-Díaz, G | 1 |
| Fastag, D | 1 |
| Kwon, G | 1 |
| Hill, JR | 1 |
| Corbett, JA | 1 |
| McDaniel, ML | 1 |
| Vainio, H | 1 |
| Morgan, G | 1 |
| Weddle, DL | 1 |
| Tithoff, P | 1 |
| Williams, M | 1 |
| Schuller, HM | 1 |
| Takahashi, M | 1 |
| Furukawa, F | 1 |
| Toyoda, K | 1 |
| Sato, H | 1 |
| Hasegawa, R | 1 |
| Imaida, K | 1 |
| Hayashi, Y | 1 |
| Hamilton, J | 1 |
| Subbarao, V | 1 |
| Granack, K | 1 |
| Ts'ao, C | 1 |
| Moertel, CG | 1 |
| Ahmann, DL | 1 |
| Taylor, WF | 1 |
| Schwartau, N | 1 |
14 reviews available for aspirin and Cancer of Pancreas
| Article | Year |
|---|---|
Aspirin use and pancreatic cancer risk: A systematic review of observational studies.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; China; Dose-Response Relationship, Drug; Dru | 2019 |
Aspirin: a potential therapeutic approach in pancreatic cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Aspirin; Cycloox | 2013 |
High-dose aspirin consumption contributes to decreased risk for pancreatic cancer in a systematic review and meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Dose-Response Relationship, | 2014 |
Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment.
Topics: AMP-Activated Protein Kinases; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Repositioning; | 2014 |
Aspirin might reduce the incidence of pancreatic cancer: A meta-analysis of observational studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Humans; Pancreatic Neoplasms | 2015 |
The Role of Common Pharmaceutical Agents on the Prevention and Treatment of Pancreatic Cancer.
Topics: Adrenergic beta-Antagonists; Anticarcinogenic Agents; Antineoplastic Agents; Aspirin; Dipeptidyl-Pep | 2016 |
Aspirin in pancreatic cancer: chemopreventive effects and therapeutic potentials.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Cancer Pain; Humans; Metformin; Pancreatic Neoplasms | 2016 |
Inhibitory effects of acetylsalicylic acid on exocrine pancreatic carcinogenesis.
Topics: Acinar Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Az | 2013 |
Epidemiology of pancreatic cancer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cholecystectomy; Cholelithiasis; Chronic Disease; | 2004 |
Molecular targets of nitric-oxide-donating aspirin in cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Cell Division; C | 2005 |
NF-kappaB, inflammation and pancreatic carcinogenesis: NF-kappaB as a chemoprevention target (review).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Aspirin; Cell Pr | 2006 |
Aspirin and nonsteroidal anti-inflammatory drug use and risk of pancreatic cancer: a meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Male; Pancreatic Neoplasms; Risk; | 2006 |
[Cancer of the pancreas. Epidemiology and risk factors].
Topics: Adenomatous Polyposis Coli; Age Factors; Aged; Aspirin; Breast Neoplasms; Diabetes Mellitus, Type 2; | 2007 |
Non-steroidal anti-inflammatory drugs and chemoprevention of cancer.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; beta Carotene; Case-Control Studie | 2000 |
3 trials available for aspirin and Cancer of Pancreas
| Article | Year |
|---|---|
A Phase Ib Study of the Combination of Personalized Autologous Dendritic Cell Vaccine, Aspirin, and Standard of Care Adjuvant Chemotherapy Followed by Nivolumab for Resected Pancreatic Adenocarcinoma-A Proof of Antigen Discovery Feasibility in Three Patie
Topics: Amino Acid Sequence; Antigens, Neoplasm; Antineoplastic Agents, Immunological; Aspirin; Carcinoma, P | 2019 |
Pilot study of nitric oxide-donating aspirin in patients with pancreatic cancer pain.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Male; Pain; Pancreatic Neopl | 2006 |
Aspirin and pancreatic cancer pain.
Topics: Adenocarcinoma; Aspirin; Carcinoma; Codeine; Colonic Neoplasms; Humans; Pancreatic Neoplasms; Placeb | 1971 |
56 other studies available for aspirin and Cancer of Pancreas
| Article | Year |
|---|---|
Phospho-Aspirin (MDC-22) inhibits pancreatic cancer growth in patient-derived tumor xenografts and KPC mice by targeting EGFR: Enhanced efficacy in combination with irinotecan.
Topics: Animals; Antineoplastic Agents; Aspirin; Disease Models, Animal; Drug Therapy, Combination; ErbB Rec | 2022 |
Risk factors for the occurrence of ampullary tumors: A case-control study.
Topics: Adenoma; Ampulla of Vater; Aspirin; Carcinoma; Case-Control Studies; Common Bile Duct Neoplasms; Duo | 2022 |
Effects of low-dose aspirin on clinical outcome and disease progression in patients with gastroenteropancreatic neuroendocrine neoplasm.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Disease Progression; F | 2019 |
The association between use of statin or aspirin and pancreatic ductal adenocarcinoma: A nested case-control study in a Korean nationwide cohort.
Topics: Adult; Aged; Aspirin; Carcinoma, Pancreatic Ductal; Case-Control Studies; Female; Humans; Hydroxymet | 2019 |
The Epidemiology of Pancreatic Cancer and the Association With Acetylsalicylic Acid in the United States: A Population-Based Study.
Topics: Adolescent; Adult; Age Distribution; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Databas | 2020 |
Effect of platelet inhibition with perioperative aspirin on survival in patients undergoing curative resection for pancreatic cancer: a propensity score matched analysis.
Topics: Aspirin; Humans; Pancreatic Neoplasms; Perioperative Care; Platelet Aggregation Inhibitors; Propensi | 2021 |
Novel Seleno-Aspirinyl Compound AS-10 Induces Apoptosis, G1 Arrest of Pancreatic Ductal Adenocarcinoma Cells, Inhibits Their NF-κB Signaling, and Synergizes with Gemcitabine Cytotoxicity.
Topics: Acetylcysteine; Adenocarcinoma; Apoptosis; Aspirin; Carcinoma, Pancreatic Ductal; Caspases; Cell Lin | 2021 |
Novel Seleno-Aspirinyl Compound AS-10 Induces Apoptosis, G1 Arrest of Pancreatic Ductal Adenocarcinoma Cells, Inhibits Their NF-κB Signaling, and Synergizes with Gemcitabine Cytotoxicity.
Topics: Acetylcysteine; Adenocarcinoma; Apoptosis; Aspirin; Carcinoma, Pancreatic Ductal; Caspases; Cell Lin | 2021 |
Novel Seleno-Aspirinyl Compound AS-10 Induces Apoptosis, G1 Arrest of Pancreatic Ductal Adenocarcinoma Cells, Inhibits Their NF-κB Signaling, and Synergizes with Gemcitabine Cytotoxicity.
Topics: Acetylcysteine; Adenocarcinoma; Apoptosis; Aspirin; Carcinoma, Pancreatic Ductal; Caspases; Cell Lin | 2021 |
Novel Seleno-Aspirinyl Compound AS-10 Induces Apoptosis, G1 Arrest of Pancreatic Ductal Adenocarcinoma Cells, Inhibits Their NF-κB Signaling, and Synergizes with Gemcitabine Cytotoxicity.
Topics: Acetylcysteine; Adenocarcinoma; Apoptosis; Aspirin; Carcinoma, Pancreatic Ductal; Caspases; Cell Lin | 2021 |
Aspirin and Pancreatic Cancer-Response.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Inhibitor of Apoptosis Proteins; Pancreati | 2017 |
Aspirin and Pancreatic Cancer-Letter.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Inhibitor of Apoptosis Proteins; Pancreati | 2017 |
Low-Dose Aspirin and Pancreatic Cancer Risk-Reply.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Pancreas; Pancreatic Neoplasms; Risk | 2017 |
Low-Dose Aspirin and Pancreatic Cancer Risk-Letter.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Pancreas; Pancreatic Neoplasms; Risk | 2017 |
Exclusive and Combined Use of Statins and Aspirin and the Risk of Pancreatic Cancer: a Case-Control Study.
Topics: Aged; Aspirin; Case-Control Studies; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutary | 2017 |
Exclusive and Combined Use of Statins and Aspirin and the Risk of Pancreatic Cancer: a Case-Control Study.
Topics: Aged; Aspirin; Case-Control Studies; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutary | 2017 |
Exclusive and Combined Use of Statins and Aspirin and the Risk of Pancreatic Cancer: a Case-Control Study.
Topics: Aged; Aspirin; Case-Control Studies; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutary | 2017 |
Exclusive and Combined Use of Statins and Aspirin and the Risk of Pancreatic Cancer: a Case-Control Study.
Topics: Aged; Aspirin; Case-Control Studies; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutary | 2017 |
Regular Use of Aspirin or Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs Is Not Associated With Risk of Incident Pancreatic Cancer in Two Large Cohort Studies.
Topics: Adenocarcinoma; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; | 2018 |
Pancreatic cancer: No risk from aspirin in pancreatic cancer.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Humans; Pancreatic | 2018 |
Chemoprevention with Enalapril and Aspirin in Men1(+/T) Knockout Mouse Model.
Topics: Animals; Aspirin; Chemoprevention; Enalapril; Mice; Mice, Knockout; Multiple Endocrine Neoplasia Typ | 2018 |
Aspirin Does Not Prevent Pancreatic Cancer in a Large Asian Cohort.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Asian People; Aspirin; Cohort Studies; Female; | 2019 |
Cyclooxygenase-2 and Cytosolic Phospholipase A2 Are Overexpressed in Mucinous Pancreatic Cysts.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Carcinoma, Pancreatic Ductal; Cyclooxygenase 2; Cyclooxygen | 2019 |
The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspirin; Cell Line, Tumor; Cell Survival; Curcumin; | 2013 |
Aspirin prolongs survival and reduces the number of Foxp3+ regulatory T cells in a genetically engineered mouse model of pancreatic cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Aspirin; Carcinoma, Pancreatic Ductal; Cyclooxygenase Inhi | 2013 |
A novel combinatorial nanotechnology-based oral chemopreventive regimen demonstrates significant suppression of pancreatic cancer neoplastic lesions.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemot | 2013 |
Case-control study of aspirin use and risk of pancreatic cancer.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Female; Humans; Incide | 2014 |
Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells.
Topics: Antineoplastic Agents; Aspirin; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell | 2014 |
Targeting IL-17 for pancreatic cancer prevention.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Aspirin; Carcinoma, Pancreatic Duct | 2014 |
Aspirin counteracts cancer stem cell features, desmoplasia and gemcitabine resistance in pancreatic cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Biomarkers, Tumor; Carcinoma, Panc | 2015 |
Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Aspirin; Bcl-2-Like Protei | 2015 |
Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy.
Topics: Aspirin; Cell Line, Tumor; Down-Regulation; Drug Synergism; Gene Expression Profiling; Gene Expressi | 2015 |
Atorvastatin (Lipitor) attenuates the effects of aspirin on pancreatic cancerogenesis and the chemotherapeutic efficacy of gemcitabine on pancreatic cancer by promoting M2 polarized tumor associated macrophages.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimetabolites, Antineoplastic; Aspirin; Atorvastatin; C | 2016 |
Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice.
Topics: Animals; Antineoplastic Agents; Aspirin; Carcinogenesis; Cell Proliferation; Chemoprevention; Female | 2016 |
Aspirin use and the incidence of breast, colon, ovarian, and pancreatic cancers in elderly women in the Iowa Women's Health Study.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; | 2016 |
Nonsteroidal anti-inflammatory drugs, statins, and pancreatic cancer risk: a population-based case-control study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studi | 2016 |
Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC.
Topics: Aspirin; Blood Platelets; Carcinogenesis; Cell Communication; Cell Line, Tumor; Cell Proliferation; | 2017 |
Aspirin Use and Reduced Risk of Pancreatic Cancer.
Topics: Age Factors; Aged; Aspirin; Case-Control Studies; China; Dose-Response Relationship, Drug; Drug Admi | 2017 |
Nitric oxide-donating aspirin inhibits the growth of pancreatic cancer cells through redox-dependent signaling.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Cell Line, Tumor; Cell Proliferation; C | 2009 |
Damage to cellular and isolated DNA induced by a metabolite of aspirin.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aspirin; Cell Line, Tumor; Comet Assay; Copper; Deoxyguanosine; DNA Bre | 2009 |
The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer.
Topics: Amylases; Angiotensin-Converting Enzyme Inhibitors; Animals; Anticarcinogenic Agents; Aspirin; Carci | 2010 |
Aspirin inhibits proliferation of gemcitabine-resistant human pancreatic cancer cells and augments gemcitabine-induced cytotoxicity.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Aspirin; Blotting, Western; Cell Cycle; Cell Line, Tumor | 2010 |
Modelling a dream: the molecular prevention of pancreatic cancer.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Disease Models, Animal; Drug Therapy, Combination; Enalap | 2010 |
Aspirin use and pancreatic cancer risk.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; As | 2010 |
Aspirin, nonsteroidal anti-inflammatory drugs, acetaminophen, and pancreatic cancer risk: a clinic-based case-control study.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Car | 2011 |
Chemoprevention of pancreatic cancer using solid-lipid nanoparticulate delivery of a novel aspirin, curcumin and sulforaphane drug combination regimen.
Topics: Apoptosis; Aspirin; Cell Line, Tumor; Cell Survival; Chemoprevention; Curcumin; Drug Combinations; D | 2012 |
Inhibition of pancreatic intraepithelial neoplasia progression to carcinoma by nitric oxide-releasing aspirin in p48(Cre/+)-LSL-Kras(G12D/+) mice.
Topics: Animals; Anticarcinogenic Agents; Aspirin; beta Catenin; Body Weight; Carcinoma in Situ; Carcinoma, | 2012 |
Association between nonsteroidal anti-inflammatory drug use and the incidence of pancreatic cancer.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Female; Humans; Inc | 2002 |
Regular use of aspirin and pancreatic cancer risk.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cancer Care Facili | 2002 |
Aspirin may lower risk of pancreatic cancer.
Topics: Aspirin; Female; Humans; Pancreatic Neoplasms; Postmenopause | 2002 |
What now for aspirin and cancer prevention?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Humans; Pancreatic | 2004 |
A prospective study of aspirin use and the risk of pancreatic cancer in women.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Utilization; Female; Humans; Middle Ag | 2004 |
Aspirin use and pancreatic cancer mortality in a large United States cohort.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Confounding Factors, | 2004 |
Re: A prospective study of aspirin use and the risk of pancreatic cancer in women.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Female; Humans; Inciden | 2004 |
Anti-inflammatory drugs and malignancy: can an aspirin a day keep cancer at bay?
Topics: Aspirin; Breast Neoplasms; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Female; Humans; Male; Ne | 2005 |
Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Female; | 2005 |
Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Aspirin; Carcinogens; Cell Growth Processes; Cricetinae | 2006 |
Molecular characterization of cytotoxic and resistance mechanisms induced by NCX 4040, a novel NO-NSAID, in pancreatic cancer cell lines.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Caspase 9; Cell Cycle; | 2006 |
Effects of aspirin on nitric oxide formation and de novo protein synthesis by RINm5F cells and rat islets.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line, Transformed; Cells, Cultured; | 1997 |
Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas.
Topics: Adenocarcinoma; Adrenergic beta-Antagonists; Arachidonic Acid; Aspirin; Base Sequence; DNA Primers; | 2001 |
Effects of various prostaglandin synthesis inhibitors on pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl)amine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carcinogens; Cricetinae; Female; Indometh | 1990 |
Platelet interaction with a pancreatic ascites tumor.
Topics: Animals; Antithrombin III; Apyrase; Ascites; Aspirin; Blood Coagulation; Blood Platelets; Cricetinae | 1986 |