Page last updated: 2024-10-23

aspirin and Brain Thrombosis

aspirin has been researched along with Brain Thrombosis in 39 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"The antithrombotic, antiplatelet and endothelial activity of terutroban, a specific thromboxane prostaglandin receptor antagonist, was assessed in patients previously treated with aspirin for the prevention of ischemic stroke."9.14Effect of the thromboxane prostaglandin receptor antagonist terutroban on arterial thrombogenesis after repeated administration in patients treated for the prevention of ischemic stroke. ( Bal Dit Sollier, C; Bergmann, JF; Bousser, MG; Crassard, I; Drouet, L; Simoneau, G, 2009)
"Warfarin, in combination with aspirin or given alone, was superior to aspirin alone in reducing the incidence of composite events after an acute myocardial infarction but was associated with a higher risk of bleeding."9.10Warfarin, aspirin, or both after myocardial infarction. ( Abdelnoor, M; Arnesen, H; Erikssen, J; Hurlen, M; Smith, P, 2002)
"Thalidomide has been associated with venous thrombotic events, as reported in the post-marketing surveillance reports by Celgene Corporation; as well as case reports in the literature."5.33Arterial thrombosis in four patients treated with thalidomide. ( Brown, K; Chanan-Khan, A; Hahn, T; McCarthy, PL; Paplham, P; Roy, H; Scarpace, SL; van Besien, K, 2005)
"The antithrombotic, antiplatelet and endothelial activity of terutroban, a specific thromboxane prostaglandin receptor antagonist, was assessed in patients previously treated with aspirin for the prevention of ischemic stroke."5.14Effect of the thromboxane prostaglandin receptor antagonist terutroban on arterial thrombogenesis after repeated administration in patients treated for the prevention of ischemic stroke. ( Bal Dit Sollier, C; Bergmann, JF; Bousser, MG; Crassard, I; Drouet, L; Simoneau, G, 2009)
"Warfarin, in combination with aspirin or given alone, was superior to aspirin alone in reducing the incidence of composite events after an acute myocardial infarction but was associated with a higher risk of bleeding."5.10Warfarin, aspirin, or both after myocardial infarction. ( Abdelnoor, M; Arnesen, H; Erikssen, J; Hurlen, M; Smith, P, 2002)
" In the CAPRIE (Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events) Trial, clopidogrel (clopidogrel bisulphate) was superior to acetylsalicylic acid (ASA) in reducing the combined risk of ischaemic stroke (IS), myocardial infarction (MI) or vascular death in patients with symptomatic atherosclerosis."4.81From CURE to MATCH: ADP receptor antagonists as the treatment of choice for high-risk atherothrombotic patients. ( Hacke, W, 2002)
" Prevention with aspirin or heparin was administered in ten cases during pregnancy, and in all the cases with heparin in postpartum."3.81[Thrombosis risk during pregnancy after history of cerebral venous thrombosis]. ( Neau, JP; Pierre, F; Pouget-Abadie, JF; Pourrat, O, 2015)
" The patient was subsequently found to have incomplete inhibition of platelet activity despite being on clopidogrel 150 mg and aspirin 81 mg daily and having a normal CYP-2C19 genotype, suggesting that suboptimal antiplatelet inhibition, secondary to morbid obesity, contributed to his in-stent thrombosis."3.79Obesity and intracranial in-stent thrombosis. ( Koch, S; Reyes-Iglesias, Y; Rose, DZ; Yavagal, DR, 2013)
" We report an independent 88-year-old female, on aspirin only for chronic atrial fibrillation, who presented with a 12-hour history of acute lumbar back pain, urinary incontinence and progressive bilateral lower limb paresis."3.76Spontaneous spinal epidural haematoma in a geriatric patient on aspirin. ( Dimou, J; Jithoo, R; Morokoff, A, 2010)
"Warfarin increases both the likelihood and the mortality of intracerebral hemorrhage (ICH), particularly in patients with a history of prior ICH."3.72Can patients be anticoagulated after intracerebral hemorrhage? A decision analysis. ( Eckman, MH; Greenberg, SM; Knudsen, KA; Rosand, J; Singer, DE, 2003)
"Hemorrhagic stroke is the most common type of obstetric stroke."2.72Stroke in Pregnancy: A Multidisciplinary Approach. ( Camargo, EC; Singhal, AB, 2021)
"Aspirin is a more potent inhibitor of Cox-1 than of Cox-2, unlike other non-steroidal anti-inflammatory drugs (NSAIDs), which have limited selectivity."2.41Vascular biology of thrombosis: platelet-vessel wall interactions and aspirin effects. ( Catella-Lawson, F, 2001)
"Imaging revealed an acute cerebral venous thrombosis."1.48CO poisoning as an associated risk factor for CVT. ( Gibb, GJ; Laghari, FJ; Phinney, TA, 2018)
"Aspirin was restarted on the first postoperative day and clopidogrel was restarted on the second postoperative day."1.38Perioperative management of a neurosurgical patient requiring antiplatelet therapy. ( Gregory Thompson, B; Rohatgi, P; Than, KD; Wilson, TJ, 2012)
"Aspirin resistance was determined by platelet aggregation (>20%) to one or more of the four agonists, namely arachidonic acid (1."1.35Aspirin resistance in South African Caucasian patients with thrombotic cerebrovascular events. ( Becker, PJ; Bernstein, PL; Connor, MD; Jacobson, BF, 2009)
"Thalidomide has been associated with venous thrombotic events, as reported in the post-marketing surveillance reports by Celgene Corporation; as well as case reports in the literature."1.33Arterial thrombosis in four patients treated with thalidomide. ( Brown, K; Chanan-Khan, A; Hahn, T; McCarthy, PL; Paplham, P; Roy, H; Scarpace, SL; van Besien, K, 2005)
"Strokes were subtyped according to inferred mechanism."1.32Thrombin generation in non-cardioembolic stroke subtypes: the Hemostatic System Activation Study. ( Barzegar, S; Bauer, K; Costigan, T; Furie, KL; Kistler, JP; Mohr, JP; Rosenberg, R; Rosner, B; Sciacca, R; Thompson, JL; Thornell, B, 2004)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.56)18.2507
2000's18 (46.15)29.6817
2010's18 (46.15)24.3611
2020's2 (5.13)2.80

Authors

AuthorsStudies
Peterson, BE1
Bhatt, DL1
Camargo, EC1
Singhal, AB1
Phinney, TA1
Gibb, GJ1
Laghari, FJ1
Godier, A1
Mesnil, M1
De Mesmay, M1
Dagois, S1
Thion, LA1
Dupont, C1
Mazighi, M1
Devys, JM1
Pourrat, O1
Neau, JP1
Pouget-Abadie, JF1
Pierre, F1
Pumar, JM1
Banguero, A1
Arias-Rivas, S1
Blanco, M2
Rodríguez-Yáñez, M1
Sucasas, P1
Castiñeira-Mourenza, JA1
Vázquez-Herrero, F1
Joly, B1
Menard, AL1
Ozkul-Wermester, O1
Triquenot-Bagan, A1
Guegan-Massardier, E1
Borg, JY1
Le Cam-Duchez, V1
Mahawish, K1
Barinov, EF1
Mamedaliyeva, S1
Tverdokhleb, TA1
Martinez-Moreno, R1
Aguilar, M1
Wendl, C1
Bäzner, H1
Ganslandt, O1
Henkes, H1
Hagen, MW1
Girdhar, G1
Wainwright, J1
Hinds, MT1
Connors, CW1
Nguyen, JD1
Bernstein, PL1
Jacobson, BF1
Connor, MD1
Becker, PJ1
Bal Dit Sollier, C1
Crassard, I1
Simoneau, G1
Bergmann, JF1
Bousser, MG1
Drouet, L1
Gomez, CR1
Qureshi, AI1
Dimou, J1
Jithoo, R1
Morokoff, A1
Rechner, AR1
Meckel, S1
Singh, TP1
Undrén, P1
Ramgren, B1
Nilsson, OG1
Phatouros, C1
McAuliffe, W1
Cronqvist, M1
Suslina, ZA1
Tanashian, MM1
Domashenko, MA1
Lansberg, MG1
O'Donnell, MJ1
Khatri, P1
Lang, ES1
Nguyen-Huynh, MN1
Schwartz, NE1
Sonnenberg, FA1
Schulman, S1
Vandvik, PO1
Spencer, FA1
Alonso-Coello, P1
Guyatt, GH1
Akl, EA1
Asil, T1
Ir, N1
Karaduman, F1
Cagli, B1
Tuncel, S1
Than, KD1
Rohatgi, P1
Wilson, TJ1
Gregory Thompson, B1
Rose, DZ1
Koch, S1
Reyes-Iglesias, Y1
Yavagal, DR1
Hurlen, M1
Abdelnoor, M1
Smith, P1
Erikssen, J1
Arnesen, H1
Eckman, MH1
Rosand, J1
Knudsen, KA1
Singer, DE1
Greenberg, SM1
Crome, P1
Epstein, EF1
Furie, KL1
Rosenberg, R1
Thompson, JL1
Bauer, K1
Mohr, JP1
Rosner, B1
Sciacca, R1
Barzegar, S1
Thornell, B1
Costigan, T1
Kistler, JP1
Scarpace, SL1
Hahn, T1
Roy, H1
Brown, K1
Paplham, P1
Chanan-Khan, A1
van Besien, K1
McCarthy, PL1
Hori, M1
Fiorella, D1
Thiabolt, L1
Albuquerque, FC1
Deshmukh, VR1
McDougall, CG1
Rasmussen, PA1
Katkova, OV1
Laguta, PS1
Panchenko, EP1
Lee, DH1
Arat, A1
Morsi, H1
Shaltoni, H1
Harris, JR1
Mawad, ME1
Kawano, KI1
Fujishima, K1
Ikeda, Y1
Kondo, K1
Umemura, K1
Lenzi, GL1
Lenzi, J1
Mostardini, C1
Wada, Y1
Mizushige, K1
Ohmori, K1
Iwado, Y1
Kohno, M1
Matsuo, H1
Catella-Lawson, F1
Müller, TH1
Morais, J1
Hacke, W1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Aspirin Non-responsiveness and Clopidogrel Endpoint Trial.[NCT00222261]Phase 41,001 participants (Actual)Interventional2003-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for aspirin and Brain Thrombosis

ArticleYear
Looking into the next decade of antithrombotic therapy for patients with atrial fibrillation and percutaneous coronary intervention.
    Journal of thrombosis and thrombolysis, 2020, Volume: 49, Issue:4

    Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Cardiology; Coronary Thrombosis; Drug Therapy, Combina

2020
Stroke in Pregnancy: A Multidisciplinary Approach.
    Obstetrics and gynecology clinics of North America, 2021, Volume: 48, Issue:1

    Topics: Aspirin; Brain Diseases; Cardiomyopathies; Cesarean Section; Eclampsia; Embolism, Paradoxical; Femal

2021
Platelet function testing in clinical diagnostics.
    Hamostaseologie, 2011, May-02, Volume: 31, Issue:2

    Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Hemorrhage; Humans; Intracranial Embolism; Intracranial T

2011
[Resistance to antiplatelet drugs in patients with cerebrovascular disorders].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 2011, Issue:7

    Topics: Arachidonate Lipoxygenases; Aspirin; Biotransformation; Blood Platelets; Clopidogrel; Dose-Response

2011
Antiplatelet therapy in neuroendovascular therapeutics.
    Neurosurgery clinics of North America, 2005, Volume: 16, Issue:3

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Intracranial Aneurysm

2005
[Therapy with aspirin: a new look at the old problem].
    Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery, 2007, Volume: 13, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biological Availability; Coronary Thrombosis; Cycl

2007
Vascular biology of thrombosis: platelet-vessel wall interactions and aspirin effects.
    Neurology, 2001, Volume: 57, Issue:5 Suppl 2

    Topics: Aspirin; Blood Platelets; Cell Communication; Cerebral Arteries; Humans; Intracranial Thrombosis; Pl

2001
Inhibition of thrombus formation by low-dose acetylsalicylic acid, dipyridamole, and their combination in a model of platelet-vessel wall interaction.
    Neurology, 2001, Volume: 57, Issue:5 Suppl 2

    Topics: Aspirin; Blood Platelets; Cell Communication; Cerebral Arteries; Clinical Trials, Phase I as Topic;

2001
From CURE to MATCH: ADP receptor antagonists as the treatment of choice for high-risk atherothrombotic patients.
    Cerebrovascular diseases (Basel, Switzerland), 2002, Volume: 13 Suppl 1

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Drug Therapy, Combination; Heparin; Humans; Intracranial Art

2002

Trials

4 trials available for aspirin and Brain Thrombosis

ArticleYear
Effect of the thromboxane prostaglandin receptor antagonist terutroban on arterial thrombogenesis after repeated administration in patients treated for the prevention of ischemic stroke.
    Cerebrovascular diseases (Basel, Switzerland), 2009, Volume: 28, Issue:5

    Topics: Aged; Aged, 80 and over; Aspirin; Biomarkers; Brain Ischemia; Clopidogrel; Double-Blind Method; Drug

2009
Warfarin, aspirin, or both after myocardial infarction.
    The New England journal of medicine, 2002, Sep-26, Volume: 347, Issue:13

    Topics: Aged; Anticoagulants; Aspirin; Disease-Free Survival; Drug Therapy, Combination; Female; Hemorrhage;

2002
Inhibition of thrombus formation by low-dose acetylsalicylic acid, dipyridamole, and their combination in a model of platelet-vessel wall interaction.
    Neurology, 2001, Volume: 57, Issue:5 Suppl 2

    Topics: Aspirin; Blood Platelets; Cell Communication; Cerebral Arteries; Clinical Trials, Phase I as Topic;

2001
Insights from CURE: using clopidogrel on top of standard therapy.
    Cerebrovascular diseases (Basel, Switzerland), 2002, Volume: 13 Suppl 1

    Topics: Aged; Angina, Unstable; Aspirin; Clopidogrel; Double-Blind Method; Female; Follow-Up Studies; Hepari

2002

Other Studies

27 other studies available for aspirin and Brain Thrombosis

ArticleYear
CO poisoning as an associated risk factor for CVT.
    The American journal of emergency medicine, 2018, Volume: 36, Issue:6

    Topics: Anticoagulants; Aspirin; Carbon Monoxide Poisoning; Female; Headache Disorders; Humans; Intracranial

2018
Bridging antiplatelet therapy with cangrelor in patients with recent intracranial stenting undergoing invasive procedures: a prospective case series.
    British journal of anaesthesia, 2019, Volume: 123, Issue:1

    Topics: Adenosine Monophosphate; Aspirin; Brain; Female; Fibrinolytic Agents; Humans; Intracranial Aneurysm;

2019
[Thrombosis risk during pregnancy after history of cerebral venous thrombosis].
    La Revue de medecine interne, 2015, Volume: 36, Issue:1

    Topics: Adult; Anticoagulants; Aspirin; Chemoprevention; Family Health; Female; Humans; Intracranial Thrombo

2015
[Rescue treatment in acute thrombosis of intracranial stents].
    Revista de neurologia, 2014, Feb-01, Volume: 58, Issue:3

    Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Basilar Artery; Capillary Permeability; Cerebral Angiogr

2014
Involvement of Arg306 mutation in factor V gene in two young men with ischemic stroke.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2014, Volume: 25, Issue:8

    Topics: Anticholesteremic Agents; Arginine; Aspirin; Brain Ischemia; DNA Mutational Analysis; Factor V; Fibr

2014
Hyperdense basilar artery sign.
    BMJ case reports, 2015, Feb-16, Volume: 2015

    Topics: Aspirin; Basilar Artery; Diagnosis, Differential; Fibrinolytic Agents; Heparin; Humans; Intracranial

2015
[Interaction of the Humoral Agonist During the Platelets Activation in Patients with Chronic Cerebral Ischemia].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 2015, Issue:3

    Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Brain; Brain Ischemia; Chronic Disease; Epin

2015
Fatal Thrombosis of a Flow Diverter due to Ibuprofen-related Antagonization of Acetylsalicylic Acid.
    Clinical neuroradiology, 2016, Volume: 26, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Vessel Prosthesis; Drug Antagonism; Drug Int

2016
Thrombogenicity of flow diverters in an ex vivo shunt model: effect of phosphorylcholine surface modification.
    Journal of neurointerventional surgery, 2017, Volume: 9, Issue:10

    Topics: Animals; Arteriovenous Shunt, Surgical; Aspirin; Clopidogrel; Embolization, Therapeutic; Intracrania

2017
Management of a Patient Requiring Intrathecal Drain Insertion and Removal in the Setting of Concomitant Dual Antiplatelet Therapy With Clopidogrel and Aspirin: A Case Report.
    A & A case reports, 2017, Jun-01, Volume: 8, Issue:11

    Topics: Aspirin; Catheters, Indwelling; Clopidogrel; Device Removal; Drainage; Drug Therapy, Combination; En

2017
Aspirin resistance in South African Caucasian patients with thrombotic cerebrovascular events.
    Journal of the neurological sciences, 2009, Feb-15, Volume: 277, Issue:1-2

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Drug Resistance; Female; Humans; Intracranial Thrombosis; M

2009
Medical treatment of patients with intracranial atherosclerotic disease.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2009, Volume: 19 Suppl 1

    Topics: Anticoagulants; Aspirin; Atherosclerosis; Brain Ischemia; Cilostazol; Clopidogrel; Dipyridamole; Emb

2009
Spontaneous spinal epidural haematoma in a geriatric patient on aspirin.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2010, Volume: 17, Issue:1

    Topics: Age Factors; Aged, 80 and over; Aspirin; Atrial Fibrillation; Decompression, Surgical; Female; Hemat

2010
Endovascular treatment using predominantly stent-assisted coil embolization and antiplatelet and anticoagulation management of ruptured blood blister-like aneurysms.
    AJNR. American journal of neuroradiology, 2011, Volume: 32, Issue:4

    Topics: Adult; Aged; Aneurysm, Ruptured; Anticoagulants; Aspirin; Cerebral Angiography; Clopidogrel; Combine

2011
Antithrombotic and thrombolytic therapy for ischemic stroke: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
    Chest, 2012, Volume: 141, Issue:2 Suppl

    Topics: Aspirin; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Therapy, Combination; Evi

2012
Combined antithrombotic treatment with aspirin and clopidogrel for patients with capsular warning syndrome: a case report.
    The neurologist, 2012, Volume: 18, Issue:2

    Topics: Aged; Aspirin; Clopidogrel; Female; Humans; Internal Capsule; Intracranial Thrombosis; Ischemic Atta

2012
Perioperative management of a neurosurgical patient requiring antiplatelet therapy.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2012, Volume: 19, Issue:9

    Topics: Aged; Aspirin; Cerebral Angiography; Clopidogrel; Humans; Intracranial Aneurysm; Intracranial Thromb

2012
Obesity and intracranial in-stent thrombosis.
    Journal of neurointerventional surgery, 2013, Sep-01, Volume: 5, Issue:5

    Topics: Abciximab; Angioplasty, Balloon; Antibodies, Monoclonal; Aspirin; Body Mass Index; Brain Ischemia; C

2013
Can patients be anticoagulated after intracerebral hemorrhage? A decision analysis.
    Stroke, 2003, Volume: 34, Issue:7

    Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Cerebral Hemorrhage; Cohort Studies; Decision Su

2003
Using prescribing indicators to measure the quality of prescribing to elderly medical in-patients.
    Age and ageing, 2004, Volume: 33, Issue:1

    Topics: Aged; Aspirin; Drug Prescriptions; Humans; Intracranial Thrombosis; Medical Records; Warfarin

2004
Thrombin generation in non-cardioembolic stroke subtypes: the Hemostatic System Activation Study.
    Neurology, 2004, Sep-14, Volume: 63, Issue:5

    Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Biomarkers; Brain Infarction; Brain Ischemia; Coho

2004
Arterial thrombosis in four patients treated with thalidomide.
    Leukemia & lymphoma, 2005, Volume: 46, Issue:2

    Topics: Aged; Arterial Occlusive Diseases; Aspirin; Drug Therapy, Combination; Female; Humans; Intracranial

2005
[Primary prevention of thrombosis for patients with atrial fibrillation].
    Rinsho shinkeigaku = Clinical neurology, 2004, Volume: 44, Issue:11

    Topics: Aged; Aspirin; Atrial Fibrillation; Humans; Intracranial Thrombosis; Japan; Practice Guidelines as T

2004
Dual antiplatelet therapy monitoring for neurointerventional procedures using a point-of-care platelet function test: a single-center experience.
    AJNR. American journal of neuroradiology, 2008, Volume: 29, Issue:7

    Topics: Adult; Aged; Angioplasty, Balloon; Aspirin; Cerebrovascular Disorders; Clopidogrel; Drug Administrat

2008
ME3277, a GPIIb/IIIa antagonist reduces cerebral infarction without enhancing intracranial hemorrhage in photothrombotic occlusion of rabbit middle cerebral artery.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:6

    Topics: Amides; Animals; Arterial Occlusive Diseases; Aspirin; Bleeding Time; Cerebrovascular Circulation; F

2000
Thromboembolic neurologic events in patients with antiphospholipid-antibody syndrome.
    Italian journal of neurological sciences, 1999, Volume: 20, Issue:1

    Topics: Administration, Oral; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Autoimmune Diseases; Hemor

1999
Prevention of cerebral thromboembolism by low-dose anticoagulant therapy in atrial fibrillation with mitral regurgitation.
    Journal of cardiovascular pharmacology, 2001, Volume: 37, Issue:4

    Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Cerebrovascular Circulation; Echocardiography; F

2001