aspirin has been researched along with Brain Neoplasms in 24 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There have been few studies of sufficient size to address the relationship between glioma risk and the use of aspirin or NSAIDs, and results have been conflicting." | 9.01 | Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis. ( Ali-Osman, F; Amirian, ES; Amos, CI; Armstrong, GN; Barnholtz-Sloan, JS; Bernstein, JL; Bondy, ML; Claus, EB; Gu, X; Houlston, RS; Il'yasova, D; Jacobs, DI; Jalali, A; Jenkins, RB; Johansen, C; Lachance, DH; Lai, RK; Melin, B; Merrell, RT; Olson, SH; Ostrom, QT; Sadetzki, S; Scheurer, ME; Schildkraut, JM; Shete, S; Wrensch, MR, 2019) |
| "Clinically, high cyclooxygenase-2 expression in malignant glioma correlates well with poor prognosis and the use of aspirin is associated with a reduced risk of glioma." | 7.96 | Aspirin Induced Glioma Apoptosis through Noxa Upregulation. ( Chang, CY; Chen, CJ; Chen, WY; Li, JR; Liao, SL; Ou, YC; Pan, PH; Wang, JD; Wang, WY, 2020) |
| "Few studies have examined the association between use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) and risk of glioma and the results have been equivocal." | 7.79 | Use of low-dose aspirin and non-aspirin nonsteroidal anti-inflammatory drugs and risk of glioma: a case-control study. ( Friis, S; Gaist, D; García-Rodríguez, LA; Hallas, J; Sørensen, HT, 2013) |
| " Using cultures of rodent and human malignant glioma cell lines, we demonstrated that millimolar concentrations of acetylsalicylate, acetaminophen, and ibuprofen all significantly reduce cell numbers after several days of culture." | 7.70 | Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture. ( Casper, D; Jaggernauth, WA; LaSala, PA; Lekhraj, R; Pidel, A; Rowe, JD; Tribius, S; Werner, P; Yaparpalvi, US, 2000) |
| "The effect of non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (commonly known as aspirin), salicylic acid, piroxicam and indomethacin on the growth of rat glioma cells (RG 2) in vitro and aspirin in vivo was studied." | 7.69 | Growth inhibition of rat glioma cells in vitro and in vivo by aspirin. ( Aas, AT; Brun, A; Salford, LG; Tønnessen, TI, 1995) |
| "Aspirin treatment inhibited cell proliferation and caused early apoptosis in glioma, coupled with reduced S100A9 levels." | 5.39 | Overexpression of S100A9 in human glioma and in-vitro inhibition by aspirin. ( Chen, S; Cheng, Y; Deng, J; Huang, N; Huang, Q; Liao, P; Wang, F, 2013) |
| "Indomethacin 8 microM was effective at 1 hour and the inhibition persisted beyond 24 hours (p < 0." | 5.32 | Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells. ( Cheng, CY; Howng, SL; Hwang, SL; Hwang, YF; Lee, KS; Lieu, AS; Lin, CL; Loh, JK; Su, YF, 2004) |
| "There have been few studies of sufficient size to address the relationship between glioma risk and the use of aspirin or NSAIDs, and results have been conflicting." | 5.01 | Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis. ( Ali-Osman, F; Amirian, ES; Amos, CI; Armstrong, GN; Barnholtz-Sloan, JS; Bernstein, JL; Bondy, ML; Claus, EB; Gu, X; Houlston, RS; Il'yasova, D; Jacobs, DI; Jalali, A; Jenkins, RB; Johansen, C; Lachance, DH; Lai, RK; Melin, B; Merrell, RT; Olson, SH; Ostrom, QT; Sadetzki, S; Scheurer, ME; Schildkraut, JM; Shete, S; Wrensch, MR, 2019) |
| "Clinically, high cyclooxygenase-2 expression in malignant glioma correlates well with poor prognosis and the use of aspirin is associated with a reduced risk of glioma." | 3.96 | Aspirin Induced Glioma Apoptosis through Noxa Upregulation. ( Chang, CY; Chen, CJ; Chen, WY; Li, JR; Liao, SL; Ou, YC; Pan, PH; Wang, JD; Wang, WY, 2020) |
| "Few studies have examined the association between use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) and risk of glioma and the results have been equivocal." | 3.79 | Use of low-dose aspirin and non-aspirin nonsteroidal anti-inflammatory drugs and risk of glioma: a case-control study. ( Friis, S; Gaist, D; García-Rodríguez, LA; Hallas, J; Sørensen, HT, 2013) |
| "The aetiology of primary brain tumours is largely unknown; the role of non-steroidal anti-inflammatory drugs (NSAIDs) or aspirin use and glioma risk has been inconclusive, but few population-based studies with reliable prescribing data have been conducted, and the association with meningioma risk has yet to be assessed." | 3.79 | Non-steroidal anti-inflammatory drug use and brain tumour risk: a case-control study within the Clinical Practice Research Datalink. ( Bannon, FJ; Cardwell, CR; Fleming, SJ; Gavin, AT; Hughes, CM; Murray, LJ; O'Rorke, MA, 2013) |
| " Using cultures of rodent and human malignant glioma cell lines, we demonstrated that millimolar concentrations of acetylsalicylate, acetaminophen, and ibuprofen all significantly reduce cell numbers after several days of culture." | 3.70 | Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture. ( Casper, D; Jaggernauth, WA; LaSala, PA; Lekhraj, R; Pidel, A; Rowe, JD; Tribius, S; Werner, P; Yaparpalvi, US, 2000) |
| "The effect of non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (commonly known as aspirin), salicylic acid, piroxicam and indomethacin on the growth of rat glioma cells (RG 2) in vitro and aspirin in vivo was studied." | 3.69 | Growth inhibition of rat glioma cells in vitro and in vivo by aspirin. ( Aas, AT; Brun, A; Salford, LG; Tønnessen, TI, 1995) |
| "This syndrome results in early onset colorectal cancer, leukemia and lymphoma, brain tumors and other malignancies." | 2.58 | Cancer prevention by aspirin in children with Constitutional Mismatch Repair Deficiency (CMMRD). ( Brüggemann, RJ; Burn, J; Hoogerbrugge, N; Jongmans, MCJ; Kratz, C; Leenders, EKSM; Loeffen, J; Westdorp, H, 2018) |
| "Spontaneous intracranial hemorrhage (ICH) is a frequent and severe consequence of primary brain tumors." | 1.91 | Antiplatelet medications and intracranial hemorrhage in patients with primary brain tumors. ( Elavalakanar, P; Ma, S; Marquez-Garcia, J; Miller, E; Neuberg, D; Panoff, S; Patell, R; Pinson, A; Ren, S; Sharma, R; Soman, S; Uhlmann, E; Weber, G; Zwicker, JI, 2023) |
| " GA enhanced the survival of EAC-bearing mice at a dosage of 0." | 1.48 | From epidemiology to treatment: Aspirin's prevention of brain and breast-cancer and cardioprotection may associate with its metabolite gentisic acid. ( Altinoz, MA; Cengiz, S; Elmaci, I; Emekli-Alturfan, E; Ozpinar, A, 2018) |
| "Glioma and meningioma are uncommon tumors of the brain with few known risk factors." | 1.43 | Analgesic use and the risk of primary adult brain tumor. ( Anic, GA; Chowdhary, SA; Egan, KM; Forsyth, PA; LaRocca, RV; Nabors, LB; Olson, JJ; Rozmeski, CM; Thompson, RC; Thompson, ZJ, 2016) |
| "Aspirin treatment inhibited cell proliferation and caused early apoptosis in glioma, coupled with reduced S100A9 levels." | 1.39 | Overexpression of S100A9 in human glioma and in-vitro inhibition by aspirin. ( Chen, S; Cheng, Y; Deng, J; Huang, N; Huang, Q; Liao, P; Wang, F, 2013) |
| "Indomethacin 8 microM was effective at 1 hour and the inhibition persisted beyond 24 hours (p < 0." | 1.32 | Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells. ( Cheng, CY; Howng, SL; Hwang, SL; Hwang, YF; Lee, KS; Lieu, AS; Lin, CL; Loh, JK; Su, YF, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 13 (54.17) | 24.3611 |
| 2020's | 4 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Marx, S | 1 |
| Altmann, R | 1 |
| Baschin, M | 1 |
| Paland, H | 1 |
| Rauch, B | 1 |
| Kohlmann, T | 1 |
| Schroeder, HWS | 1 |
| Ma, S | 1 |
| Patell, R | 1 |
| Miller, E | 1 |
| Ren, S | 1 |
| Marquez-Garcia, J | 1 |
| Panoff, S | 1 |
| Sharma, R | 1 |
| Pinson, A | 1 |
| Elavalakanar, P | 1 |
| Weber, G | 1 |
| Uhlmann, E | 1 |
| Neuberg, D | 1 |
| Soman, S | 1 |
| Zwicker, JI | 1 |
| Chang, CY | 1 |
| Pan, PH | 1 |
| Li, JR | 1 |
| Ou, YC | 1 |
| Wang, JD | 1 |
| Liao, SL | 1 |
| Chen, WY | 1 |
| Wang, WY | 1 |
| Chen, CJ | 1 |
| Ming, J | 1 |
| Sun, B | 1 |
| Li, Z | 1 |
| Lin, L | 1 |
| Meng, X | 1 |
| Han, B | 1 |
| Wang, R | 1 |
| Wu, P | 1 |
| Li, J | 1 |
| Cai, J | 1 |
| Jiang, C | 1 |
| Altinoz, MA | 1 |
| Elmaci, I | 1 |
| Cengiz, S | 1 |
| Emekli-Alturfan, E | 1 |
| Ozpinar, A | 1 |
| Leenders, EKSM | 1 |
| Westdorp, H | 1 |
| Brüggemann, RJ | 1 |
| Loeffen, J | 1 |
| Kratz, C | 1 |
| Burn, J | 1 |
| Hoogerbrugge, N | 1 |
| Jongmans, MCJ | 1 |
| Navone, SE | 1 |
| Guarnaccia, L | 1 |
| Cordiglieri, C | 1 |
| Crisà, FM | 1 |
| Caroli, M | 1 |
| Locatelli, M | 1 |
| Schisano, L | 1 |
| Rampini, P | 1 |
| Miozzo, M | 1 |
| La Verde, N | 1 |
| Riboni, L | 1 |
| Campanella, R | 1 |
| Marfia, G | 1 |
| Amirian, ES | 1 |
| Ostrom, QT | 1 |
| Armstrong, GN | 1 |
| Lai, RK | 1 |
| Gu, X | 1 |
| Jacobs, DI | 1 |
| Jalali, A | 1 |
| Claus, EB | 1 |
| Barnholtz-Sloan, JS | 1 |
| Il'yasova, D | 1 |
| Schildkraut, JM | 1 |
| Ali-Osman, F | 1 |
| Sadetzki, S | 1 |
| Jenkins, RB | 1 |
| Lachance, DH | 1 |
| Olson, SH | 1 |
| Bernstein, JL | 1 |
| Merrell, RT | 1 |
| Wrensch, MR | 1 |
| Johansen, C | 1 |
| Houlston, RS | 1 |
| Scheurer, ME | 1 |
| Shete, S | 1 |
| Amos, CI | 1 |
| Melin, B | 1 |
| Bondy, ML | 1 |
| Mihajluk, K | 1 |
| Simms, C | 1 |
| Reay, M | 1 |
| Madureira, PA | 1 |
| Howarth, A | 1 |
| Murray, P | 1 |
| Nasser, S | 1 |
| Duckworth, CA | 1 |
| Pritchard, DM | 1 |
| Pilkington, GJ | 1 |
| Hill, R | 1 |
| Mormile, R | 1 |
| Gaist, D | 1 |
| García-Rodríguez, LA | 1 |
| Sørensen, HT | 1 |
| Hallas, J | 1 |
| Friis, S | 1 |
| Bannon, FJ | 1 |
| O'Rorke, MA | 1 |
| Murray, LJ | 1 |
| Hughes, CM | 1 |
| Gavin, AT | 1 |
| Fleming, SJ | 1 |
| Cardwell, CR | 1 |
| Huang, N | 1 |
| Chen, S | 1 |
| Deng, J | 1 |
| Huang, Q | 1 |
| Liao, P | 1 |
| Wang, F | 1 |
| Cheng, Y | 1 |
| Rahman, M | 1 |
| Donnangelo, LL | 1 |
| Neal, D | 1 |
| Mogali, K | 1 |
| Decker, M | 1 |
| Ahmed, MM | 1 |
| Egan, KM | 1 |
| Nabors, LB | 1 |
| Thompson, ZJ | 1 |
| Rozmeski, CM | 1 |
| Anic, GA | 1 |
| Olson, JJ | 1 |
| LaRocca, RV | 1 |
| Chowdhary, SA | 1 |
| Forsyth, PA | 1 |
| Thompson, RC | 1 |
| Chen, G | 1 |
| Salih, SB | 1 |
| Saeed, AB | 1 |
| Alzahrani, M | 1 |
| Al Qahtani, M | 1 |
| Haider, A | 1 |
| Palker, V | 1 |
| Serebruany, VL | 1 |
| Dinicolantonio, JJ | 1 |
| Can, MM | 1 |
| Goto, S | 1 |
| Hwang, SL | 1 |
| Lee, KS | 1 |
| Lin, CL | 1 |
| Lieu, AS | 1 |
| Cheng, CY | 1 |
| Loh, JK | 1 |
| Hwang, YF | 1 |
| Su, YF | 1 |
| Howng, SL | 1 |
| Emregül, E | 1 |
| Aas, AT | 1 |
| Tønnessen, TI | 1 |
| Brun, A | 1 |
| Salford, LG | 1 |
| Varner, A | 1 |
| Casper, D | 1 |
| Lekhraj, R | 1 |
| Yaparpalvi, US | 1 |
| Pidel, A | 1 |
| Jaggernauth, WA | 1 |
| Werner, P | 1 |
| Tribius, S | 1 |
| Rowe, JD | 1 |
| LaSala, PA | 1 |
| Giese, A | 1 |
| Hagel, C | 1 |
| Kim, EL | 1 |
| Zapf, S | 1 |
| Djawaheri, J | 1 |
| Berens, ME | 1 |
| Westphal, M | 1 |
2 reviews available for aspirin and Brain Neoplasms
| Article | Year |
|---|---|
Cancer prevention by aspirin in children with Constitutional Mismatch Repair Deficiency (CMMRD).
Topics: Aspirin; Brain Neoplasms; Child; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis | 2018 |
Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; Case-Control Studies; Glioma; Hum | 2019 |
22 other studies available for aspirin and Brain Neoplasms
| Article | Year |
|---|---|
Preoperative Thrombocytosis is Not Associated with Overall Survival in 309 Glioblastoma Patients.
Topics: Aspirin; Brain Neoplasms; Fibrinogen; Glioblastoma; Humans; Prognosis; Retrospective Studies; Thromb | 2022 |
Antiplatelet medications and intracranial hemorrhage in patients with primary brain tumors.
Topics: Aspirin; Brain Neoplasms; Humans; Intracranial Hemorrhages; Platelet Aggregation Inhibitors; Retrosp | 2023 |
Aspirin Induced Glioma Apoptosis through Noxa Upregulation.
Topics: Animals; Aspirin; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Endoplasmic | 2020 |
Aspirin inhibits the SHH/GLI1 signaling pathway and sensitizes malignant glioma cells to temozolomide therapy.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Aspirin; Brain Neoplasms; Cell Line, Tumor; Dacarbazin | 2017 |
From epidemiology to treatment: Aspirin's prevention of brain and breast-cancer and cardioprotection may associate with its metabolite gentisic acid.
Topics: Animals; Aspirin; Brain Neoplasms; Breast Neoplasms; Carcinoma, Ehrlich Tumor; Cardiotonic Agents; C | 2018 |
Aspirin Affects Tumor Angiogenesis and Sensitizes Human Glioblastoma Endothelial Cells to Temozolomide, Bevacizumab, and Sunitinib, Impairing Vascular Endothelial Growth Factor-Related Signaling.
Topics: Angiogenesis Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antineoplas | 2018 |
RETRACTED: IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Brain Neoplasms; Cell Hypoxia; Dru | 2019 |
Aspirin Use and Risk of Glioma: a Double Track for a Single Goal?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; Glioma; Humans | 2020 |
Use of low-dose aspirin and non-aspirin nonsteroidal anti-inflammatory drugs and risk of glioma: a case-control study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; C | 2013 |
Non-steroidal anti-inflammatory drug use and brain tumour risk: a case-control study within the Clinical Practice Research Datalink.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; Case-Control Studies | 2013 |
Overexpression of S100A9 in human glioma and in-vitro inhibition by aspirin.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blotting, Western; Brain Neoplas | 2013 |
Effects of Perioperative Acetyl Salicylic Acid on Clinical Outcomes in Patients Undergoing Craniotomy for Brain Tumor.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Brain Neoplasms; Child; C | 2015 |
Analgesic use and the risk of primary adult brain tumor.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non | 2016 |
[Interpretation of the updates of NCCN 2017 version 1.0 guideline for colorectal cancer].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Com | 2017 |
Primary CNS lymphoma presenting as fever of unknown origin.
Topics: Antihypertensive Agents; Antineoplastic Agents; Antitubercular Agents; Aspirin; Brain Neoplasms; Cra | 2009 |
Unclassified pleomorphic and spindle cell pulmonary neoplasm with brain metastases after prasugrel.
Topics: Aged; Aspirin; Brain Neoplasms; Carcinoma; Clinical Trials, Phase III as Topic; Clopidogrel; Colonic | 2013 |
Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; Dinoprostone; Dose-Response Relat | 2004 |
Development of a new biosensor for superoxide radicals.
Topics: Ascorbic Acid; Aspirin; Biosensing Techniques; Brain; Brain Neoplasms; Cross-Linking Reagents; Elect | 2005 |
Growth inhibition of rat glioma cells in vitro and in vivo by aspirin.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; | 1995 |
Re: Trends in reported incidence of primary malignant brain tumors in children in the United States.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; Child; Child, Prescho | 1999 |
Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture.
Topics: Acetaminophen; Adult; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Brain; Brain Neoplasms; Ce | 2000 |
Thromboxane synthase regulates the migratory phenotype of human glioma cells.
Topics: Arachidonic Acids; Aspirin; Astrocytes; Benzofurans; Brain Neoplasms; Cell Adhesion; Cell Movement; | 1999 |