Page last updated: 2024-10-23

aspirin and Brain Disorders

aspirin has been researched along with Brain Disorders in 37 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"Acute hepatic decompensation and encephalopathy may occur as a consequence of aspirin hepatoxicity in JRA and justify sequential observations of liver function tests and salicylate levels in such patients."5.26Hepatoxicity with encephalopathy associated with aspirin therapy in rheumatoid arthritis. ( Crain, JD; Gelfand, EW; Grand, RJ; Ulshen, MH, 1978)
" Aspirin effectively abolished SPA in 50 patients and relieved the clinical symptoms of patients with recurrent complaints of transient blindness and paraesthesia."3.66Spontaneous platelet aggregation in cerebrovascular disease. ( Jenkins, CS; Oosterhuis, H; Prenger, D; ten Cate, JW; Vos, J, 1978)
"Hemorrhagic stroke is the most common type of obstetric stroke."2.72Stroke in Pregnancy: A Multidisciplinary Approach. ( Camargo, EC; Singhal, AB, 2021)
"Treatment with aspirin and ceftriaxone followed by trimethoprim-sulfamethoxazole resulted in a good neurological recovery and complete remission of the malabsorption syndrome."1.33A patient with cerebral Whipple's disease and a stroke-like syndrome. ( De Simone, C; Famularo, G; Minisola, G, 2005)
"Polyarteritis nodosa is a difficult condition to diagnose in a child and can cause brainstem lesions."1.32Ocular tilt reaction due to a mesencephalic lesion in juvenile polyarteritis nodosa. ( Chong, WK; Dillon, MJ; Elston, J; Harris, CM; Ragge, NK; Taylor, DS, 2003)
" There was no significant difference in the AUC-value between the two routes of administration, but a slower rate of absorption with no clear peak effect was found after rectal administration."1.26Bioavailability of rectal aspirin in neurosurgical patients. ( Kanto, J; Klossner, J; Mäntylä, R; Yrjänä, T, 1981)
"Acute hepatic decompensation and encephalopathy may occur as a consequence of aspirin hepatoxicity in JRA and justify sequential observations of liver function tests and salicylate levels in such patients."1.26Hepatoxicity with encephalopathy associated with aspirin therapy in rheumatoid arthritis. ( Crain, JD; Gelfand, EW; Grand, RJ; Ulshen, MH, 1978)
"Hallucinations were either unformed (for example, bright lights, straight lines) or highly formed (for example, faces), in which case they were invariably recognized by the patient as inappropriate."1.25Cerebral disorders of vision in systemic lupus erythematosus. ( Brandt, KD; Cohen, AS; Lessell, S, 1975)
"A case of hepatotoxicity and encephalopathy (Reye's syndrome?) associated with salicylate therapy is presented and the aetiology of this syndrome is discussed."1.25Acute liver failure and encephalopathy (Reye's syndrome?) during salicylate therapy. ( Koivikko, A; Mäkelä, AL; Sillanpää, M, 1975)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199021 (56.76)18.7374
1990's4 (10.81)18.2507
2000's7 (18.92)29.6817
2010's3 (8.11)24.3611
2020's2 (5.41)2.80

Authors

AuthorsStudies
Li, J1
Chen, Y1
Liu, J1
Mai, X1
Jing, S1
Camargo, EC1
Singhal, AB1
Pandya, DJ1
Fitzsimmons, BF1
Wolfe, TJ1
Hussain, SI1
Lynch, JR1
Ortega-Gutierrez, S1
Zaidat, OO1
Alkan, O1
Yildirim, T1
Kizilkiliç, O1
Tan, M1
Cekinmez, M1
Hughes, GR1
Liu, W1
Liu, R1
Sun, W1
Peng, Q1
Zhang, W1
Xu, E1
Cheng, Y1
Ding, M1
Li, Y1
Hong, Z1
Wu, J1
Zeng, J1
Yao, C1
Huang, Y1
Ragge, NK1
Harris, CM1
Dillon, MJ1
Chong, WK1
Elston, J1
Taylor, DS1
MITSUSE, J1
MORIYAMA, K1
GILES, HM1
Farray, D1
Carman, TL1
Fernandez, BB1
Famularo, G1
Minisola, G1
De Simone, C1
Collombet, JM1
Baubichon, D1
Masqueliez, C1
Bernabé, D1
Four, E1
Burckhart, MF1
Lallement, G1
Kleffner, I1
Ringelstein, EB1
Stupp, N1
Niederstadt, TU1
Young, P1
Ducros, A1
Ducobu, J1
Dupont, P1
Viinikka, L1
Dewanjee, MK1
Fuster, V1
Rao, SA1
Forshaw, PL1
Kaye, MP1
Kanto, J1
Klossner, J1
Mäntylä, R1
Yrjänä, T1
Yatsu, FM1
Enserink, M1
Morgan, MK1
Sekhon, LH1
Finfer, S1
Grinnell, V1
McDonald, L1
ten Cate, JW1
Vos, J1
Oosterhuis, H1
Prenger, D1
Jenkins, CS1
Ulshen, MH1
Grand, RJ1
Crain, JD1
Gelfand, EW1
Thaler, MM1
Brandt, KD1
Lessell, S1
Cohen, AS1
Sillanpää, M1
Mäkelä, AL1
Koivikko, A1
Rosenfeld, RG1
Liebhaber, MI1
Koike, T1
Minakawa, T1
Abe, H1
Takeuchi, S1
Sasaki, O1
Nishimaki, K1
Tanaka, R1
Dickey, W1
Morrow, JI1
Smith, DB1
Hitchcock, M1
Philpott, PJ1
Baker, M1
Weiss, HJ1
Hilty, MD1
Romshe, CA1
Delamater, PV1
Boyd, EM1
Meloff, K1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Cilostazol Stroke Prevention Study-a Randomized, Double Blind, Double Dummy, Parallel Comparative, Multicenter Clinical Trial[NCT00202020]Phase 3720 participants Interventional2004-05-31Completed
MRI Evaluation of Nidus Occlusion After Gamma Knife Radiosurgery of Cerebral Arteriovenous Malformations - A Prospective Preliminary Study[NCT03995823]50 participants (Anticipated)Observational2019-07-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for aspirin and Brain Disorders

ArticleYear
Stroke in Pregnancy: A Multidisciplinary Approach.
    Obstetrics and gynecology clinics of North America, 2021, Volume: 48, Issue:1

    Topics: Aspirin; Brain Diseases; Cardiomyopathies; Cesarean Section; Eclampsia; Embolism, Paradoxical; Femal

2021
The treatment and prevention of deep vein thrombosis in the preoperative management of patients who have neurologic diseases.
    Neurologic clinics, 2004, Volume: 22, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Brain Diseases; Chondroitin Sulfat

2004
[Acute and chronic headaches].
    La Revue du praticien, 2006, Dec-15, Volume: 56, Issue:19

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir

2006
An antagonist of prostaglandin synthesis in cardiovascular diseases.
    Annals of clinical research, 1984, Volume: 16, Issue:5-6

    Topics: Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Brain Diseases; Cardiovascular Diseases; Con

1984
Metabolic mechanisms in Reye syndrome. End of a Mystery?
    American journal of diseases of children (1960), 1976, Volume: 130, Issue:3

    Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Aspirin; Brain Diseases; Carbamoyl-Phosphate Synthase

1976
Drug-induced neurological disorders.
    Progress in neurobiology, 1990, Volume: 34, Issue:4

    Topics: Antihypertensive Agents; Aspirin; Brain Diseases; Dyskinesia, Drug-Induced; Humans; Levodopa; Nervou

1990
Encephalopathy in toxicity tests on laboratory animals.
    Archiv fur Toxikologie, 1971, Volume: 27, Issue:2

    Topics: Animals; Aspirin; Atropine; Behavior, Animal; Brain Damage, Chronic; Brain Diseases; Caffeine; Casei

1971

Trials

2 trials available for aspirin and Brain Disorders

ArticleYear
Different impacts of blood pressure variability on the progression of cerebral microbleeds and white matter lesions.
    Stroke, 2012, Volume: 43, Issue:11

    Topics: Aspirin; Blood Pressure; Brain; Brain Diseases; Cerebral Hemorrhage; Cilostazol; Disease Progression

2012
Psychopathology in systemic lupus erythematosus. I. Psychiatric observations.
    Seminars in arthritis and rheumatism, 1973, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Affective Symptoms; Aspirin; Azathioprine; Brain Diseases; Clinical Trials as Top

1973

Other Studies

28 other studies available for aspirin and Brain Disorders

ArticleYear
Is it coincidental or correlative between reversible splenial lesion syndrome and atrial septal defect?: A case report.
    Medicine, 2020, Oct-23, Volume: 99, Issue:43

    Topics: Administration, Oral; Antihypertensive Agents; Aspirin; Brain Diseases; Corpus Callosum; Diffusion M

2020
Measurement of antiplatelet inhibition during neurointerventional procedures: the effect of antithrombotic duration and loading dose.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2010, Volume: 20, Issue:1

    Topics: Aspirin; Blood Platelets; Brain Diseases; Clopidogrel; Cohort Studies; Dose-Response Relationship, D

2010
A case of ecchordosis physaliphora presenting with an intratumoral hemorrhage.
    Turkish neurosurgery, 2009, Volume: 19, Issue:3

    Topics: Aspirin; Brain Diseases; Cranial Fossa, Posterior; Hamartoma; Headache; Humans; Magnetic Resonance I

2009
Hughes syndrome (the antiphospholipid syndrome): a disease of our time.
    Inflammopharmacology, 2011, Volume: 19, Issue:2

    Topics: Abortion, Spontaneous; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Arterial Occlusive D

2011
Ocular tilt reaction due to a mesencephalic lesion in juvenile polyarteritis nodosa.
    American journal of ophthalmology, 2003, Volume: 135, Issue:2

    Topics: Aspirin; Brain Diseases; Child, Preschool; Cyclophosphamide; Diplopia; Drug Therapy, Combination; Fe

2003
[PULMONARY ENCEPHALOPATHY].
    [Sogo rinsho] Clinic all-round, 1964, Volume: 13

    Topics: Acidosis; Aspirin; Bicarbonates; Brain Diseases; Carbon Dioxide; Coma; Electroencephalography; Human

1964
ENCEPHALOPATHY AND FATTY DEGENERATION OF THE VISCERA.
    Lancet (London, England), 1965, May-15, Volume: 1, Issue:7394

    Topics: Aspirin; Brain Diseases; Carbohydrate Metabolism; Coma; Fatty Liver; Heart Diseases; Humans; Kidney

1965
A patient with cerebral Whipple's disease and a stroke-like syndrome.
    Scandinavian journal of gastroenterology, 2005, Volume: 40, Issue:5

    Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Diseases; Ceftriaxone

2005
Effects of aspirin and mefenamic acid on soman poisoning-induced neuropathology in mice.
    Drug and chemical toxicology, 2006, Volume: 29, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain; Brain Diseases; Cell Proliferation

2006
Neurological picture. Susac's syndrome: effective combination of immunosuppression and antiplatelet treatment.
    Journal of neurology, neurosurgery, and psychiatry, 2006, Volume: 77, Issue:12

    Topics: Adolescent; Aspirin; Brain Diseases; Corpus Callosum; Female; Glucocorticoids; Hearing Loss; Humans;

2006
[Inhibition of prostaglandins in the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)].
    Presse medicale (Paris, France : 1983), 1983, May-07, Volume: 12, Issue:20

    Topics: Adult; Aged; Aspirin; Brain Diseases; Ethanol; Female; Humans; Inappropriate ADH Syndrome; Indometha

1983
Noninvasive radioisotopic technique for detection of platelet deposition in mitral valve prostheses and quantitation of visceral microembolism in dogs.
    Mayo Clinic proceedings, 1983, Volume: 58, Issue:5

    Topics: Animals; Aspirin; Blood Platelets; Brain Diseases; Dipyridamole; Dogs; Embolism; Heart Valve Prosthe

1983
Bioavailability of rectal aspirin in neurosurgical patients.
    Acta anaesthesiologica Scandinavica, 1981, Volume: 25, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aspirin; Biological Availability; Brain Diseases; Female; Fever;

1981
For your stroke-prone patients: a guide to drug treatment.
    Geriatrics, 1980, Volume: 35, Issue:2

    Topics: Aged; Antihypertensive Agents; Aspirin; Brain Diseases; Cerebral Angiography; Cerebrovascular Disord

1980
Fraud and ethics charges hit stroke drug trial.
    Science (New York, N.Y.), 1996, Dec-20, Volume: 274, Issue:5295

    Topics: Aspirin; Brain Diseases; Cerebrovascular Disorders; Controlled Clinical Trials as Topic; Dipyridamol

1996
Delayed neurological deterioration following resection of arteriovenous malformations of the brain.
    Journal of neurosurgery, 1999, Volume: 90, Issue:4

    Topics: Adolescent; Adult; Aged; Anesthesia, General; Aneurysm; Anticoagulants; Antihypertensive Agents; Asp

1999
Determination of brain death via pulsatile echoencephalography.
    Journal of neurosurgical nursing, 1978, Volume: 10, Issue:4

    Topics: Adult; Aspirin; Brain Death; Brain Diseases; Brain Injuries; Cerebrovascular Circulation; Echoenceph

1978
Spontaneous platelet aggregation in cerebrovascular disease.
    Thrombosis and haemostasis, 1978, Feb-28, Volume: 39, Issue:1

    Topics: Adenosine; Adenosine Diphosphate; Adult; Aged; Aspirin; Blindness; Brain Diseases; Female; Humans; I

1978
Hepatoxicity with encephalopathy associated with aspirin therapy in rheumatoid arthritis.
    The Journal of pediatrics, 1978, Volume: 93, Issue:6

    Topics: Adolescent; Arthritis, Juvenile; Arthritis, Rheumatoid; Aspirin; Biopsy; Brain Diseases; Chemical an

1978
Cerebral disorders of vision in systemic lupus erythematosus.
    Annals of internal medicine, 1975, Volume: 83, Issue:2

    Topics: Adrenal Cortex Hormones; Adult; Aspirin; Brain Diseases; Cerebrospinal Fluid; Electroencephalography

1975
Acute liver failure and encephalopathy (Reye's syndrome?) during salicylate therapy.
    Acta paediatrica Scandinavica, 1975, Volume: 64, Issue:6

    Topics: Acute Disease; Adolescent; Aspirin; Brain Diseases; Chemical and Drug Induced Liver Injury; Female;

1975
Acute encephalopathy in siblings. Reye syndrome vs salicylate intoxication.
    American journal of diseases of children (1960), 1976, Volume: 130, Issue:3

    Topics: Aspirin; Brain; Brain Diseases; Child; Diagnosis, Differential; Female; Humans; Liver; Liver Disease

1976
PTA of supra-aortic arteries with temporary balloon occlusion to avoid distal embolism.
    Neurologia medico-chirurgica, 1992, Volume: 32, Issue:3

    Topics: Adult; Angioplasty, Balloon; Aortic Valve Stenosis; Aspirin; Brain Diseases; Carotid Artery Thrombos

1992
Cerebral amyloid angiopathy presenting as transient ischemic attacks. Case report.
    Journal of neurosurgery, 1985, Volume: 63, Issue:6

    Topics: Aged; Amyloidosis; Anticoagulants; Aspirin; Brain; Brain Diseases; Humans; Ischemic Attack, Transien

1985
Inhibition of platelet-induced thrombus formation.
    Schweizerische medizinische Wochenschrift, 1974, Jan-26, Volume: 104, Issue:4

    Topics: Adenosine; Adenosine Diphosphate; Aspirin; Blood Platelets; Brain Diseases; Dipyridamole; Epinephrin

1974
Reye's syndrome and hyperaminoacidemia.
    The Journal of pediatrics, 1974, Volume: 84, Issue:3

    Topics: Amino Acids; Aspirin; Brain Diseases; Child; Child, Preschool; Diagnosis, Differential; Fatty Liver;

1974
Reye's syndrome and salicylate intoxication.
    Pediatrics, 1970, Volume: 46, Issue:6

    Topics: Adipose Tissue; Aspirin; Brain Diseases; Chemical and Drug Induced Liver Injury; Fatty Liver; Humans

1970
Seizures and fever.
    Postgraduate medicine, 1971, Volume: 50, Issue:1

    Topics: Acetaminophen; Acidosis, Respiratory; Age Factors; Alkalosis, Respiratory; Aspirin; Brain Diseases;

1971