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aspirin and Brain Damage, Chronic

aspirin has been researched along with Brain Damage, Chronic in 16 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Brain Damage, Chronic: A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.

Research Excerpts

ExcerptRelevanceReference
" We explored the outcomes of restarting aspirin use on secondary stroke and mortality in patients with chronic stroke 4 weeks after suffering from a TBI episode in Taiwan."8.31Risk of secondary stroke subsequent to restarting aspirin in chronic stroke patients suffering from traumatic brain injury in Taiwan. ( Chien, WC; Chou, CL; Chung, CH; Fann, LY; Hsu, YH; Sun, CA; Tang, SE; Wu, CC, 2023)
"The Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction trial found no difference between warfarin and aspirin in patients with low ejection fraction in sinus rhythm for the primary outcome: first to occur of 84 incident ischemic strokes (IIS), 7 intracerebral hemorrhages or 531 deaths."7.79Stroke in heart failure in sinus rhythm: the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction trial. ( Anker, SD; Di Tullio, MR; Diek, M; Freudenberger, RS; Graham, S; Haddad, H; Homma, S; Labovitz, AJ; Lok, DJ; Mann, DL; Mohr, JP; Ponikowski, P; Pullicino, PM; Qian, M; Sacco, RL; Sanford, AR; Teerlink, JR; Thompson, JL, 2013)
"A temporary middle cerebral artery occlusion (tMCAO) model was used in 80 Wistar rats to evaluate whether a high dose of Aspirin (40 mg/kg) applied with different initiation time points after stroke onset (30 min, 3 h, 6 h, 12 h, 20 rats for each time group) and followed by repeated administration (1, 2 and 3 days) is neuroprotective."5.34Neuroprotection by early and delayed treatment of acute stroke with high dose aspirin. ( Berger, C; Grau, A; Schwab, S; Zheng, Z, 2007)
" We explored the outcomes of restarting aspirin use on secondary stroke and mortality in patients with chronic stroke 4 weeks after suffering from a TBI episode in Taiwan."4.31Risk of secondary stroke subsequent to restarting aspirin in chronic stroke patients suffering from traumatic brain injury in Taiwan. ( Chien, WC; Chou, CL; Chung, CH; Fann, LY; Hsu, YH; Sun, CA; Tang, SE; Wu, CC, 2023)
"The Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction trial found no difference between warfarin and aspirin in patients with low ejection fraction in sinus rhythm for the primary outcome: first to occur of 84 incident ischemic strokes (IIS), 7 intracerebral hemorrhages or 531 deaths."3.79Stroke in heart failure in sinus rhythm: the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction trial. ( Anker, SD; Di Tullio, MR; Diek, M; Freudenberger, RS; Graham, S; Haddad, H; Homma, S; Labovitz, AJ; Lok, DJ; Mann, DL; Mohr, JP; Ponikowski, P; Pullicino, PM; Qian, M; Sacco, RL; Sanford, AR; Teerlink, JR; Thompson, JL, 2013)
"Eptifibatide was not associated with an increase in intracranial hemorrhage, and no significant effect on nonhemorrhagic stroke was observed."2.69Stroke in patients with acute coronary syndromes: incidence and outcomes in the platelet glycoprotein IIb/IIIa in unstable angina. Receptor suppression using integrilin therapy (PURSUIT) trial. The PURSUIT Investigators. ( Alberts, MJ; Berdan, LG; Califf, RM; Deckers, J; Graffagnino, C; Granger, CB; Harrington, RA; Laskowitz, DT; Lincoff, AM; MacAulay, CM; Mahaffey, KW; Miller, JM; Simoons, ML; Sloan, MA; Topol, EJ, 1999)
" In addition, the discussion here reviews select acute ischemic stroke intravenous thrombolytic studies, such as the National Institute of Neurological Disorders and Stroke rt-PA Stroke Study and European Cooperative Acute Stroke Studies, select neuroprotectant and endovascular clot retrieval device studies, and large cooperative databases, such as the Virtual International Stroke Trials Archive and Safe Implementation of Treatment in Stroke-International Stroke Thrombolysis Registry, to explore relationships between baseline stroke severity and other possible factors associated with efficacy and safety outcomes."2.48How baseline severity affects efficacy and safety outcomes in acute ischemic stroke intervention trials. ( Gorelick, PB, 2012)
"A temporary middle cerebral artery occlusion (tMCAO) model was used in 80 Wistar rats to evaluate whether a high dose of Aspirin (40 mg/kg) applied with different initiation time points after stroke onset (30 min, 3 h, 6 h, 12 h, 20 rats for each time group) and followed by repeated administration (1, 2 and 3 days) is neuroprotective."1.34Neuroprotection by early and delayed treatment of acute stroke with high dose aspirin. ( Berger, C; Grau, A; Schwab, S; Zheng, Z, 2007)
"It is concluded that the groups with alcohol abuse who used hepatotoxic drugs showed a picture of cortical changes (wide transport sulci and clear-cut or high-grade cortical changes) and also of subcortical aberrations, expressed as an increased widening of the third ventricle."1.28Computed tomography of the brain, hepatotoxic drugs and high alcohol consumption in male alcoholic patients and a random sample from the general male population. ( Mützell, S, 1992)
"The reasons given for treating fever were to make the child comfortable (99%), to prevent seizures (63%), and to satisfy parents (44%)."1.27House officer management of the febrile child. A survey. ( Herskowitz, L; Weiss, J, 1983)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19903 (18.75)18.7374
1990's4 (25.00)18.2507
2000's4 (25.00)29.6817
2010's4 (25.00)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Chou, CL1
Chung, CH1
Hsu, YH1
Wu, CC1
Sun, CA1
Chien, WC1
Tang, SE1
Fann, LY1
Pullicino, PM1
Thompson, JL1
Sacco, RL1
Sanford, AR1
Qian, M1
Teerlink, JR1
Haddad, H1
Diek, M1
Freudenberger, RS1
Labovitz, AJ1
Di Tullio, MR1
Lok, DJ1
Ponikowski, P1
Anker, SD1
Graham, S1
Mann, DL1
Mohr, JP2
Homma, S1
Sanchez, J1
Illnait, J1
Mas, R1
Mendoza, S1
Fernandez, L1
Mesa, M1
Vega, H1
Fernandez, J1
Reyes, P1
Ruiz, D1
Wong, DK1
Lurie, F1
Wong, LL1
Leroux, P1
Hennebert, C1
Catteau, J1
Legros, H1
Hennebert, O1
Laudenbach, V1
Marret, S1
Gorelick, PB1
Khalifeh, MR1
Redett, RJ1
Zheng, Z1
Schwab, S1
Grau, A1
Berger, C1
Weiss, J1
Herskowitz, L1
Pickard, JD1
Walker, V1
Brandt, L1
Zygmunt, S1
Smythe, J1
Hartmann, A1
Mahaffey, KW1
Harrington, RA1
Simoons, ML1
Granger, CB1
Graffagnino, C1
Alberts, MJ1
Laskowitz, DT1
Miller, JM1
Sloan, MA1
Berdan, LG1
MacAulay, CM1
Lincoff, AM1
Deckers, J1
Topol, EJ1
Califf, RM1
Diener, HC1
Mützell, S1
Boyd, EM1
Lipsmeyer, E1
Ackerman, GL1

Reviews

4 reviews available for aspirin and Brain Damage, Chronic

ArticleYear
How baseline severity affects efficacy and safety outcomes in acute ischemic stroke intervention trials.
    Annals of the New York Academy of Sciences, 2012, Volume: 1268

    Topics: Acute Disease; Anticoagulants; Aspirin; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage;

2012
The management of patients on anticoagulants prior to cutaneous surgery: case report of a thromboembolic complication, review of the literature, and evidence-based recommendations.
    Plastic and reconstructive surgery, 2006, Volume: 118, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Atrial Fibrillation; Brain Damage,

2006
Stroke prevention: antiplatelet and antithrombolytic therapy.
    Haemostasis, 2000, Volume: 30 Suppl 3

    Topics: Anticoagulants; Aspirin; Brain Damage, Chronic; Carotid Stenosis; Clinical Trials as Topic; Clopidog

2000
Encephalopathy in toxicity tests on laboratory animals.
    Archiv fur Toxikologie, 1971, Volume: 27, Issue:2

    Topics: Animals; Aspirin; Atropine; Behavior, Animal; Brain Damage, Chronic; Brain Diseases; Caffeine; Casei

1971

Trials

2 trials available for aspirin and Brain Damage, Chronic

ArticleYear
[Long-term effect of policosanol on the functional recovery of non-cardioembolic ischemic stroke patients: a one year study].
    Revista de neurologia, 2017, Feb-16, Volume: 64, Issue:4

    Topics: Aged; Aged, 80 and over; Anticholesteremic Agents; Aspirin; Brain Damage, Chronic; Brain Ischemia; C

2017
Stroke in patients with acute coronary syndromes: incidence and outcomes in the platelet glycoprotein IIb/IIIa in unstable angina. Receptor suppression using integrilin therapy (PURSUIT) trial. The PURSUIT Investigators.
    Circulation, 1999, May-11, Volume: 99, Issue:18

    Topics: Acute Disease; Age Factors; Aged; Angina, Unstable; Aspirin; Brain Damage, Chronic; Cerebral Hemorrh

1999

Other Studies

10 other studies available for aspirin and Brain Damage, Chronic

ArticleYear
Risk of secondary stroke subsequent to restarting aspirin in chronic stroke patients suffering from traumatic brain injury in Taiwan.
    Scientific reports, 2023, 05-17, Volume: 13, Issue:1

    Topics: Adult; Aspirin; Brain Damage, Chronic; Brain Injuries, Traumatic; Drug Therapy, Combination; Female;

2023
Stroke in heart failure in sinus rhythm: the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction trial.
    Cerebrovascular diseases (Basel, Switzerland), 2013, Volume: 36, Issue:1

    Topics: Anticoagulants; Aspirin; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Heart Failure;

2013
The effects of clopidogrel on elderly traumatic brain injured patients.
    The Journal of trauma, 2008, Volume: 65, Issue:6

    Topics: Aged; Aspirin; Brain Damage, Chronic; Brain Injuries; Cardiovascular Diseases; Case-Control Studies;

2008
Neuroprotective effects vary across nonsteroidal antiinflammatory drugs in a mouse model of developing excitotoxic brain injury.
    Neuroscience, 2010, May-19, Volume: 167, Issue:3

    Topics: Acetaminophen; Adrenal Cortex Hormones; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Ste

2010
Neuroprotection by early and delayed treatment of acute stroke with high dose aspirin.
    Brain research, 2007, Volume: 1186

    Topics: Acute Disease; Animals; Aspirin; Brain; Brain Damage, Chronic; Dose-Response Relationship, Drug; Dru

2007
House officer management of the febrile child. A survey.
    Clinical pediatrics, 1983, Volume: 22, Issue:11

    Topics: Acetaminophen; Aspirin; Brain Damage, Chronic; Fever; Humans; Infant; Seizures; Surveys and Question

1983
Effect of intraventricular haemorrhage and rebleeding following subarachnoid haemorrhage on CSF eicosanoids.
    Acta neurochirurgica, 1994, Volume: 129, Issue:3-4

    Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Brain Damage, Chronic; Cerebral Ventricles; Dexamethasone; Di

1994
Treatment of acute ischemic stroke: where are we?
    Neurologia (Barcelona, Spain), 1999, Volume: 14, Issue:1

    Topics: Animals; Aspirin; Brain Damage, Chronic; Brain Ischemia; Calcium Channel Blockers; Cerebral Hemorrha

1999
Computed tomography of the brain, hepatotoxic drugs and high alcohol consumption in male alcoholic patients and a random sample from the general male population.
    Upsala journal of medical sciences, 1992, Volume: 97, Issue:2

    Topics: Adult; Aged; Alcoholism; Analgesics; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Antipyrine; Aspiri

1992
Irreversible brain damage after water intoxication.
    JAMA, 1966, Apr-18, Volume: 196, Issue:3

    Topics: Aged; Aspirin; Brain Damage, Chronic; Epilepsy, Tonic-Clonic; Female; Humans; Hypertonic Solutions;

1966