Page last updated: 2024-10-23

aspirin and Bowel Diseases, Inflammatory

aspirin has been researched along with Bowel Diseases, Inflammatory in 25 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"To determine whether aspirin or non-aspirin non-steroidal anti-inflammatory drugs (NA-NSAIDs) prevent colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD)."8.93Does aspirin or non-aspirin non-steroidal anti-inflammatory drug use prevent colorectal cancer in inflammatory bowel disease? ( Burr, NE; Hull, MA; Subramanian, V, 2016)
" We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat."7.71Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001)
"Non-aspirin NSAIDs were associated with lower PCCRC risk after a negative baseline colonoscopy."5.56Nonsteroidal anti-inflammatory drugs but not aspirin are associated with a lower risk of post-colonoscopy colorectal cancer. ( Chan, EW; Chen, L; Cheung, KS; Leung, WK; Seto, WK; Wong, ICK, 2020)
"Twenty-four patients with spondylitis and Crohn's disease or ulcerative colitis, treated with 5-ASA or sulfasalazine, were randomised and assessed by an investigator independent from the spa staff: 12 were submitted to a cycle of mud-bath treatment (12 mud packs and 12 thermal baths over a period of two weeks) and 12 were enrolled as controls."5.12Mud-bath treatment in spondylitis associated with inflammatory bowel disease--a pilot randomised clinical trial. ( Cardinale, G; Cozzi, F; Dani, L; Oliviero, F; Podswiadek, M; Punzi, L; Sfriso, P, 2007)
"To determine whether aspirin or non-aspirin non-steroidal anti-inflammatory drugs (NA-NSAIDs) prevent colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD)."4.93Does aspirin or non-aspirin non-steroidal anti-inflammatory drug use prevent colorectal cancer in inflammatory bowel disease? ( Burr, NE; Hull, MA; Subramanian, V, 2016)
" We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat."3.71Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001)
"Inflammation is a non-specific immune response to infection, irritation or other injury, the key features being redness, warmth, swelling and pain."2.49Immunoinflammatory responses in gastrointestinal tract injury and recovery. ( Alam, MM; Marella, A; Shaquiquzzaman, M; Verma, G, 2013)
" However, long-term use of NSAIDs is associated with substantial gastrointestinal toxicity and may cause an exacerbation in IBD patients."2.43Chemoprevention for colon cancer: new opportunities, fact or fiction? ( Mulder, CJ; Terhaar Sive Droste, JS; Tuynman, JB; Van Dullemen, HM, 2006)
"The role of salicylates in Crohn's disease is limited to the mild activity phase; further data are required to clarify its role in maintenance on remission."2.41New steroids and new salicylates in inflammatory bowel disease: a critical appraisal. ( Campieri, M, 2002)
"Non-aspirin NSAIDs were associated with lower PCCRC risk after a negative baseline colonoscopy."1.56Nonsteroidal anti-inflammatory drugs but not aspirin are associated with a lower risk of post-colonoscopy colorectal cancer. ( Chan, EW; Chen, L; Cheung, KS; Leung, WK; Seto, WK; Wong, ICK, 2020)
"First, patients with quiescent Crohn's disease and ulcerative colitis received the non-NSAID analgesic acetaminophen (n = 26) and the conventional NSAIDs naproxen (n = 32), diclofenac (n = 29), and indomethacin (n = 22) for 4 weeks."1.33Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease. ( Bjarnason, I; Bjornsson, E; Maiden, L; Premchand, P; Sherwood, R; Smale, S; Takeuchi, K; Thjodleifsson, B, 2006)
"Fifty-eight ulcerative colitis patients were seen with active disease, with eight (13."1.31Tolerance of nonsteroidal antiinflammatory drugs in patients with inflammatory bowel disease. ( Bayona, M; Bonner, GF; Kitchen, L; Walczak, M, 2000)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (48.00)29.6817
2010's8 (32.00)24.3611
2020's5 (20.00)2.80

Authors

AuthorsStudies
Leeds, IL1
Sklow, B1
Gorgun, E1
Liska, D1
Lightner, AL1
Hull, TL1
Steele, SR1
Holubar, SD1
Mak, JWY1
So, J1
Tang, W1
Yip, TCF1
Leung, WK2
Li, M1
Lo, FH1
Ng, KM1
Sze, SF1
Leung, CM1
Tsang, SWC1
Shan, EHS1
Chan, KH1
Lam, BCY1
Hui, AJ1
Chow, WH1
Chan, FKL1
Ng, SC1
Cheung, KS1
Chen, L1
Chan, EW1
Seto, WK1
Wong, ICK1
Elia, JR1
Pekow, J1
Patel, P1
Imazio, M1
Brucato, A1
Barbieri, A1
Ferroni, F1
Maestroni, S1
Ligabue, G1
Chinaglia, A1
Cumetti, D1
Della Casa, G1
Bonomi, F1
Mantovani, F1
Di Corato, P1
Lugli, R1
Faletti, R1
Leuzzi, S1
Bonamini, R1
Modena, MG1
Belli, R1
Verma, G1
Marella, A1
Shaquiquzzaman, M1
Alam, MM1
Singh, S1
Kullo, IJ1
Pardi, DS1
Loftus, EV1
Burr, NE1
Hull, MA1
Subramanian, V1
Chan, SS1
Hart, AR1
Beaugerie, L1
Vinod, J1
Vadada, D1
Korelitz, BI1
Sonpal, N1
Panagopoulos, G1
Baiocco, P1
Ananthakrishnan, AN1
Vogt, W1
García Rodríguez, LA1
González-Pérez, A1
Johansson, S1
Wallander, MA1
Takeuchi, K1
Smale, S1
Premchand, P1
Maiden, L1
Sherwood, R1
Thjodleifsson, B1
Bjornsson, E1
Bjarnason, I1
Terhaar Sive Droste, JS1
Tuynman, JB1
Van Dullemen, HM1
Mulder, CJ1
Maillard, MH1
Cozzi, F1
Podswiadek, M1
Cardinale, G1
Oliviero, F1
Dani, L1
Sfriso, P1
Punzi, L1
Bonner, GF1
Walczak, M1
Kitchen, L1
Bayona, M1
Fägerstam, JP1
Whiss, PA1
Ström, M1
Andersson, RG1
Kankuri, E1
Vaali, K1
Korpela, R1
Paakkari, I1
Vapaatalo, H1
Moilanen, E1
Marvisi, M1
Fornasari, G1
Campieri, M1
Geboes, K1
Dalle, I1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Dexamethasone Versus Methylprednisolone for the Treatment of Active Inflammatory Bowel Disease[NCT00152620]40 participants Interventional2004-06-30Terminated (stopped due to study completed)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

11 reviews available for aspirin and Bowel Diseases, Inflammatory

ArticleYear
Immunoinflammatory responses in gastrointestinal tract injury and recovery.
    Acta biochimica Polonica, 2013, Volume: 60, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Biogenic Polyamines; Biomarkers; Cyc

2013
Epidemiology, risk factors and management of cardiovascular diseases in IBD.
    Nature reviews. Gastroenterology & hepatology, 2015, Volume: 12, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Clopidogrel; Endothelium,

2015
Does aspirin or non-aspirin non-steroidal anti-inflammatory drug use prevent colorectal cancer in inflammatory bowel disease?
    World journal of gastroenterology, 2016, Apr-07, Volume: 22, Issue:13

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Colorectal Neoplasms; Evi

2016
Inflammatory bowel disease therapies and cancer risk: where are we and where are we going?
    Gut, 2012, Volume: 61, Issue:4

    Topics: Aspirin; Colitis; Colorectal Neoplasms; Glucocorticoids; Humans; Immunosuppressive Agents; Inflammat

2012
Environmental triggers for inflammatory bowel disease.
    Current gastroenterology reports, 2013, Volume: 15, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diet; Environment; Humans; Inflammatory Bowel Dise

2013
[Inflammatory bowel disease--diagnosis and therapy].
    Praxis, 2005, Feb-02, Volume: 94, Issue:5

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azathioprine; Colitis, Ul

2005
Chemoprevention for colon cancer: new opportunities, fact or fiction?
    Scandinavian journal of gastroenterology. Supplement, 2006, Issue:243

    Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; Colorectal Neoplas

2006
[Resolvins: new derivates of fatty acids, polyunsaturated (omega-3) with therapeutic potential in inflammatory intestinal diseases].
    Revue medicale suisse, 2006, Nov-15, Volume: 2, Issue:87

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Docosahexaenoic Acids;

2006
[Is the lung a target organ in inflammatory bowel disease?].
    Recenti progressi in medicina, 2001, Volume: 92, Issue:12

    Topics: Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bronchial Diseases

2001
New steroids and new salicylates in inflammatory bowel disease: a critical appraisal.
    Gut, 2002, Volume: 50 Suppl 3

    Topics: Acute Disease; Aspirin; Beclomethasone; Budesonide; Colitis, Ulcerative; Crohn Disease; Drug Therapy

2002
Influence of treatment on morphological features of mucosal inflammation.
    Gut, 2002, Volume: 50 Suppl 3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Colitis, Ulcerative; Crohn Disease;

2002

Trials

1 trial available for aspirin and Bowel Diseases, Inflammatory

ArticleYear
Mud-bath treatment in spondylitis associated with inflammatory bowel disease--a pilot randomised clinical trial.
    Joint bone spine, 2007, Volume: 74, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis, Ulcerative; Combined Modality Ther

2007

Other Studies

13 other studies available for aspirin and Bowel Diseases, Inflammatory

ArticleYear
Cost-Effectiveness of Aspirin for Extended Venous Thromboembolism Prophylaxis After Major Surgery for Inflammatory Bowel Disease.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2022, Volume: 26, Issue:6

    Topics: Aftercare; Anticoagulants; Aspirin; Cost-Benefit Analysis; Enoxaparin; Humans; Inflammatory Bowel Di

2022
Cancer risk and chemoprevention in Chinese inflammatory bowel disease patients: a population-based cohort study.
    Scandinavian journal of gastroenterology, 2020, Volume: 55, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; China; Cohort Studies; Colitis, Ulcerative;

2020
Nonsteroidal anti-inflammatory drugs but not aspirin are associated with a lower risk of post-colonoscopy colorectal cancer.
    Alimentary pharmacology & therapeutics, 2020, Volume: 51, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Co

2020
Aspirin, NSAIDs, and Inflammatory Bowel Disease: An Exercise Physiology Perspective.
    Inflammatory bowel diseases, 2020, 08-20, Volume: 26, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis; Humans; Inflammatory Bowel Diseases

2020
Daily Aspirin Use Does Not Impact Clinical Outcomes in Patients With Inflammatory Bowel Disease. Reply Letter to Elia et al.
    Inflammatory bowel diseases, 2020, 08-20, Volume: 26, Issue:9

    Topics: Aspirin; Colitis; Humans; Inflammatory Bowel Diseases

2020
Good prognosis for pericarditis with and without myocardial involvement: results from a multicenter, prospective cohort study.
    Circulation, 2013, Jul-02, Volume: 128, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal;

2013
Aspirin use and development of inflammatory bowel disease: confounding or causation? authors' reply.
    Alimentary pharmacology & therapeutics, 2011, Volume: 34, Issue:11-12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Inflammatory Bowel Diseases; Male;

2011
The effect of antiplatelet therapy in patients with inflammatory bowel disease.
    Journal of clinical gastroenterology, 2012, Volume: 46, Issue:6

    Topics: Aspirin; Clopidogrel; Disease Progression; Female; Humans; Inflammatory Bowel Diseases; Male; Platel

2012
Risk factors for inflammatory bowel disease in the general population.
    Alimentary pharmacology & therapeutics, 2005, Aug-15, Volume: 22, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Appendectomy; Aspirin; Cont

2005
Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2006, Volume: 4, Issue:2

    Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Colitis, Ul

2006
Tolerance of nonsteroidal antiinflammatory drugs in patients with inflammatory bowel disease.
    The American journal of gastroenterology, 2000, Volume: 95, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis, Ulcerative; Crohn Disease; Drug Utilizati

2000
Expression of platelet P-selectin and detection of soluble P-selectin, NPY and RANTES in patients with inflammatory bowel disease.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2000, Volume: 49, Issue:9

    Topics: Adult; Aged; Antigens, CD; Aspirin; Blood Platelets; Chemokine CCL5; Female; Humans; Inflammatory Bo

2000
Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.
    Inflammation, 2001, Volume: 25, Issue:5

    Topics: Acute Disease; Animals; Aspirin; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygen

2001