aspirin has been researched along with Bone Loss, Osteoclastic in 34 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "23 (60%) of 38 human breast carcinomas had significant in-vitro osteolytic activity." | 5.26 | Breast-cancer osteolysis, bone metastases, and anti-osteolytic effect of aspirin. ( Dowsett, M; Easty, DM; Easty, GC; Neville, AM; Powles, TJ, 1976) |
| "Our findings have revealed a novel osteoporosis mechanism in which activated T cells induce BMMSC apoptosis via Fas/Fas ligand pathway and suggested that pharmacologic stem cell based intervention by aspirin may be a new alternative in osteoporosis treatment including activated osteoblasts and inhibited osteoclasts." | 3.74 | Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents. ( Akiyama, K; Bi, Y; Chen, W; Gronthos, S; Gutkind, S; Le, A; Liu, Y; Miura, Y; Patel, V; Shi, S; Sonoyama, W; Wang, CY; Yamaza, T; Young, M, 2008) |
| " Levels of PGB (presumed to arise from PGE) in synovial fluids are elevated in the majority of a group of patients with inflammatory rheumatic diseases, as compared to similar patients treated with aspirin and indomethacin and patients with osteoarthritis." | 3.65 | Prostaglandins in the rheumatic diseases. ( Levine, L; McGuire, MB; Robinson, DR, 1975) |
| "Osteolysis effected in vitro by breast carcinomas can be inhibited by aspirin." | 3.65 | Human breast tumour-induced osteolysis and prostaglandins. ( Dowsett, M; Easty, DM; Easty, GC; Neville, AM; Powles, TJ, 1976) |
| "Aspirin is a commonly used antipyretic, analgesic, and anti-inflammatory drug." | 1.91 | Aspirin prevents estrogen deficiency-induced bone loss by inhibiting osteoclastogenesis and promoting osteogenesis. ( Chang, Y; Hu, Y; Kong, K; Li, H; Qiao, H; Tong, Z; Xia, R; Zhai, Z; Zhang, J, 2023) |
| "This behavior recommends that treatment of osteoporosis via calcitonin does not provide the required upshots." | 1.56 | Biophysics and the nonlinear dynamics instigated by a special hormone. ( Asif, A; Javed, S; Nutini, A; Sohail, A, 2020) |
| "Aspirin treatment did not prevent the previously reported diabetes-induced marrow adiposity." | 1.37 | Low dose aspirin therapy decreases blood glucose levels but does not prevent type i diabetes-induced bone loss. ( Coe, LM; Denison, JD; McCabe, LR, 2011) |
| "Aspirin was administered orally at the rate of 65 mg/kg per day in three divided doses and was found to effectively inhibit prostaglandin synthesis at the level of the bronchioles." | 1.28 | The effect of acetylsalicylic acid on orthodontic tooth movement in the guinea pig. ( Reynolds, EC; West, VC; Wong, A, 1992) |
| "Naproxen did not influence bone resorption or formation significantly." | 1.27 | Effects of acetylsalicylic acid and naproxen on bone resorption and formation in rats. ( Langeland, N; Rönningen, H; Solheim, LF, 1986) |
| "23 (60%) of 38 human breast carcinomas had significant in-vitro osteolytic activity." | 1.26 | Breast-cancer osteolysis, bone metastases, and anti-osteolytic effect of aspirin. ( Dowsett, M; Easty, DM; Easty, GC; Neville, AM; Powles, TJ, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (70.59) | 18.7374 |
| 1990's | 2 (5.88) | 18.2507 |
| 2000's | 2 (5.88) | 29.6817 |
| 2010's | 3 (8.82) | 24.3611 |
| 2020's | 3 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, Y | 1 |
| Kong, K | 1 |
| Tong, Z | 1 |
| Qiao, H | 1 |
| Hu, Y | 1 |
| Xia, R | 1 |
| Zhang, J | 1 |
| Zhai, Z | 1 |
| Li, H | 1 |
| Su, N | 1 |
| Villicana, C | 1 |
| Zhang, C | 1 |
| Lee, J | 1 |
| Sinha, S | 1 |
| Yang, A | 1 |
| Yang, F | 1 |
| Javed, S | 1 |
| Sohail, A | 1 |
| Asif, A | 1 |
| Nutini, A | 1 |
| Murata, N | 1 |
| Ioi, H | 1 |
| Ouchi, M | 1 |
| Takao, T | 1 |
| Oida, H | 1 |
| Aijima, R | 1 |
| Yamaza, T | 2 |
| Kido, MA | 1 |
| Miura, Y | 1 |
| Bi, Y | 1 |
| Liu, Y | 1 |
| Akiyama, K | 1 |
| Sonoyama, W | 1 |
| Patel, V | 1 |
| Gutkind, S | 1 |
| Young, M | 1 |
| Gronthos, S | 1 |
| Le, A | 1 |
| Wang, CY | 1 |
| Chen, W | 1 |
| Shi, S | 1 |
| Coe, LM | 1 |
| Denison, JD | 1 |
| McCabe, LR | 1 |
| Guo, Y | 1 |
| Zhang, CY | 1 |
| Tian, Y | 1 |
| DI, JM | 1 |
| Qin, S | 1 |
| Feldman, RS | 1 |
| Szeto, B | 1 |
| Chauncey, HH | 1 |
| Goldhaber, P | 2 |
| Heath, H | 1 |
| Weller, RE | 1 |
| Mundy, GR | 1 |
| Ueno, K | 1 |
| Kawashima, H | 1 |
| Ohnuma, N | 1 |
| Kurozumi, S | 1 |
| Hashimoto, Y | 1 |
| Orimo, H | 1 |
| Lane, NE | 1 |
| Bauer, DC | 1 |
| Nevitt, MC | 1 |
| Pressman, AR | 1 |
| Cummings, SR | 1 |
| Narumiya, S | 1 |
| FitzGerald, GA | 1 |
| Powles, TJ | 9 |
| Dowsett, M | 4 |
| Easty, GC | 9 |
| Easty, DM | 9 |
| Neville, AM | 9 |
| Short, CR | 1 |
| Beadle, RE | 1 |
| Coombes, RC | 1 |
| Gazet, JC | 2 |
| Ford, HT | 1 |
| Nash, AG | 1 |
| Baker, JW | 1 |
| Powles, JT | 1 |
| Robinson, DR | 1 |
| McGuire, MB | 1 |
| Levine, L | 3 |
| Eastman, AR | 1 |
| Harrison, SD | 1 |
| Hixon, EJ | 1 |
| Burdeshaw, JA | 1 |
| Denine, EP | 1 |
| Wong, A | 1 |
| Reynolds, EC | 1 |
| West, VC | 1 |
| Tashjian, AH | 2 |
| Voelkel, EF | 2 |
| Lazzaro, M | 1 |
| Goad, D | 1 |
| Bosma, T | 1 |
| Leung, DY | 1 |
| Key, L | 1 |
| Steinberg, JJ | 1 |
| Young, MC | 1 |
| Von Deck, M | 1 |
| Wilkinson, R | 1 |
| Geha, RS | 1 |
| Solheim, LF | 2 |
| Rönningen, H | 2 |
| Langeland, N | 2 |
| Hoffmann, O | 1 |
| Klaushofer, K | 1 |
| Koller, K | 1 |
| Peterlik, M | 1 |
| LiVolsi, VA | 1 |
| Bondy, PK | 1 |
| Munro-Neville, A | 1 |
| Haddad, JG | 1 |
| Clark, SA | 1 |
3 reviews available for aspirin and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Genetic and pharmacological analysis of prostanoid receptor function.
Topics: Animals; Aspirin; Biological Transport; Bone Resorption; Cell Nucleus; Colonic Neoplasms; Cyclooxyge | 2001 |
Pharmacology of antiarthritic drugs.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Bone Resorption; Cattle; Cyclooxygenase Inhib | 1978 |
Paget's disease of bone: problems and management.
Topics: Adrenocorticotropic Hormone; Alkaline Phosphatase; Aspirin; Bone Regeneration; Bone Resorption; Calc | 1972 |
31 other studies available for aspirin and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Aspirin prevents estrogen deficiency-induced bone loss by inhibiting osteoclastogenesis and promoting osteogenesis.
Topics: Animals; Aspirin; Bone Resorption; Cell Differentiation; Estrogens; Mice; NF-kappa B; Osteoclasts; O | 2023 |
Aspirin synergizes with mineral particle-coated macroporous scaffolds for bone regeneration through immunomodulation.
Topics: Aspirin; Bone Regeneration; Bone Resorption; Culture Media, Conditioned; Gelatin; Humans; Immunomodu | 2023 |
Biophysics and the nonlinear dynamics instigated by a special hormone.
Topics: Aspirin; Biophysical Phenomena; Bone and Bones; Bone Resorption; Calcitonin; Drug Therapy, Combinati | 2020 |
Effect of allergen sensitization on external root resorption.
Topics: Allergens; Alveolar Process; Animals; Arachidonate 5-Lipoxygenase; Aspirin; Biomechanical Phenomena; | 2013 |
Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents.
Topics: Animals; Apoptosis; Aspirin; Bone Marrow Cells; Bone Resorption; CD4-Positive T-Lymphocytes; Humans; | 2008 |
Low dose aspirin therapy decreases blood glucose levels but does not prevent type i diabetes-induced bone loss.
Topics: Adiposity; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Glucose; Bone and Bones; | 2011 |
[Effect of cyclooxygenase-2 on bone loss in ovariectomized rats].
Topics: Animals; Aspirin; Bone Density; Bone Resorption; Cyclooxygenase 2; Disease Models, Animal; Female; F | 2012 |
Non-steroidal anti-inflammatory drugs in the reduction of human alveolar bone loss.
Topics: Adult; Aged; Alveolar Process; Aspirin; Bone Resorption; Humans; Indomethacin; Male; Middle Aged; Re | 1983 |
Canine lymphosarcoma: a model for study of the hypercalcemia of cancer.
Topics: Animals; Antineoplastic Agents; Aspirin; Bone Resorption; Calcium; Disease Models, Animal; Dog Disea | 1980 |
Aspirin inhibition of hypercalcemic effect of 1 alpha-hydroxyvitamin D3 in rats.
Topics: Animals; Aspirin; Bone Resorption; Calcium; Hydroxycholecalciferols; Intestinal Absorption; Male; Ne | 1980 |
Aspirin and nonsteroidal antiinflammatory drug use in elderly women: effects on a marker of bone resorption. The Study of Osteoporotic Fractures Research Group.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Bone Density; Bone Resorption; C | 1997 |
Breast-cancer osteolysis, bone metastases, and anti-osteolytic effect of aspirin.
Topics: Animals; Aspirin; Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcium; Cultur | 1976 |
Agents affecting osteolysis in patients with breast cancer.
Topics: Anti-Inflammatory Agents; Aspirin; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcitonin; Fe | 1979 |
Prostaglandins in the rheumatic diseases.
Topics: Arthritis, Rheumatoid; Aspirin; Bone Resorption; Cell Line; Colchicine; Cyclic AMP; Flufenamic Acid; | 1975 |
Prostaglandin mediation of collagenase-induced bone resorption.
Topics: Animals; Aspirin; Bone and Bones; Bone Resorption; Culture Techniques; Indomethacin; Mice; Microbial | 1976 |
In vitro osteolysis by human breast tumours.
Topics: Aspirin; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcium; Female; Humans; In Vitro Techni | 1977 |
Effect of aspirin administration on retinoic acid toxicity in mice.
Topics: Animals; Aspirin; Bone Resorption; Female; Lethal Dose 50; Male; Mice; Prostaglandins; Tretinoin; Vi | 1977 |
Human breast tumour-induced osteolysis and prostaglandins.
Topics: Aspirin; Bone Resorption; Breast Neoplasms; Female; Humans; Indomethacin; Osteolysis; Prostaglandins | 1976 |
The effect of acetylsalicylic acid on orthodontic tooth movement in the guinea pig.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Aspirin; Bone Remodeling; Bone Resorption; Bronchoc | 1992 |
Tumor necrosis factor-alpha (cachectin) stimulates bone resorption in mouse calvaria via a prostaglandin-mediated mechanism.
Topics: Animals; Aspirin; Bone and Bones; Bone Resorption; Calcium; Cyclooxygenase Inhibitors; Dinoprostone; | 1987 |
Increased in vitro bone resorption by monocytes in the hyper-immunoglobulin E syndrome.
Topics: Aspirin; Bone Resorption; Child; Child, Preschool; Dinoprostone; Female; Humans; Hydroxyproline; Hyp | 1988 |
Effects of acetylsalicylic acid on heterotopic bone resorption and formation in rats.
Topics: Animals; Aspirin; Bone and Bones; Bone Resorption; Bone Transplantation; Collagen; Male; Minerals; O | 1986 |
Effects of acetylsalicylic acid and naproxen on bone resorption and formation in rats.
Topics: Animals; Aspirin; Bone Resorption; Male; Naproxen; Osteogenesis; Rats | 1986 |
Prostaglandin-related bone resorption in cultured neonatal mouse calvaria: evaluation of biopotency of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; B | 1985 |
Anti-metastatic effect of aspirin.
Topics: Animals; Aspirin; Bone Neoplasms; Bone Resorption; Carcinoma 256, Walker; Indomethacin; Lysosomes; N | 1973 |
Anti-metastatic effect of aspirin.
Topics: Animals; Aspirin; Bone Neoplasms; Bone Resorption; In Vitro Techniques; Indomethacin; Mice; Neoplasm | 1973 |
Tumour-induced osteolysis.
Topics: Aspirin; Bone Resorption; Enzyme Induction; Lysosomes; Neoplasms; Parathyroid Hormone; Prostaglandin | 1973 |
Aspirin inhibition of in vitro osteolysis stimulated by parathyroid hormone and PGE1.
Topics: Animals; Animals, Newborn; Aspirin; Bone Resorption; Calcium Isotopes; Mice; Mice, Inbred BALB C; Or | 1973 |
Prostaglandins, calcium metabolism and cancer.
Topics: Animals; Aspirin; Bone and Bones; Bone Resorption; Calcium; Calcium Radioisotopes; Cells, Cultured; | 1974 |
The inhibition by aspirin and indomethacin of osteolytic tumor deposits and hypercalcaemia in rats with Walker tumour, and its possible application to human breast cancer.
Topics: Animals; Aspirin; Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcium; Calciu | 1973 |
Letter: Tumor-induced osteolysis.
Topics: Animals; Aspirin; Bone Resorption; Humans; Hypercalcemia; Neoplasms; Prostaglandins | 1974 |