aspirin has been researched along with Bone Fractures in 41 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emerging evidence suggests aspirin may be an effective venous thromboembolism (VTE) prophylaxis for orthopaedic trauma patients, with fewer bleeding complications." | 9.34 | Aspirin versus low-molecular-weight heparin for venous thromboembolism prophylaxis in orthopaedic trauma patients: A patient-centered randomized controlled trial. ( Castillo, RC; Haac, BE; Manson, TT; O'Hara, NN; O'Toole, RV; Slobogean, GP; Stein, DM, 2020) |
| "Orthopedic trauma patients are often treated with venous thromboembolism (VTE) chemoprophylaxis with aspirin or low molecular weight heparin (LMWH) after discharge from their index admission, but adherence patterns are not known." | 9.27 | Post-discharge adherence with venous thromboembolism prophylaxis after orthopedic trauma: Results from a randomized controlled trial of aspirin versus low molecular weight heparin. ( Berger, PZ; Connelly, D; Degani, Y; Haac, BE; Johal, H; Manson, TT; Marinos, D; Mascarenhas, D; O'Hara, NN; O'Toole, RV; Reahl, GB; Scalea, TM; Slobogean, GP; Stein, DM; Van Besien, R, 2018) |
| "In patients with extremity fractures that had been treated operatively or with any pelvic or acetabular fracture, thromboprophylaxis with aspirin was noninferior to low-molecular-weight heparin in preventing death and was associated with low incidences of deep-vein thrombosis and pulmonary embolism and low 90-day mortality." | 5.69 | Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis after a Fracture. ( Bosse, MJ; Carlini, AR; Castillo, RC; Degani, Y; Firoozabadi, R; Frey, KP; Goldhaber, SZ; Haut, ER; Marvel, D; O'Hara, NN; O'Toole, RV; Obremskey, W; Scharfstein, DO; Slobogean, GP; Stein, DM; Sudini, K; Taylor, TJ, 2023) |
| "Emerging evidence suggests aspirin may be an effective venous thromboembolism (VTE) prophylaxis for orthopaedic trauma patients, with fewer bleeding complications." | 5.34 | Aspirin versus low-molecular-weight heparin for venous thromboembolism prophylaxis in orthopaedic trauma patients: A patient-centered randomized controlled trial. ( Castillo, RC; Haac, BE; Manson, TT; O'Hara, NN; O'Toole, RV; Slobogean, GP; Stein, DM, 2020) |
| "For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1." | 5.33 | Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2006) |
| "Orthopedic trauma patients are often treated with venous thromboembolism (VTE) chemoprophylaxis with aspirin or low molecular weight heparin (LMWH) after discharge from their index admission, but adherence patterns are not known." | 5.27 | Post-discharge adherence with venous thromboembolism prophylaxis after orthopedic trauma: Results from a randomized controlled trial of aspirin versus low molecular weight heparin. ( Berger, PZ; Connelly, D; Degani, Y; Haac, BE; Johal, H; Manson, TT; Marinos, D; Mascarenhas, D; O'Hara, NN; O'Toole, RV; Reahl, GB; Scalea, TM; Slobogean, GP; Stein, DM; Van Besien, R, 2018) |
| "Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted." | 4.31 | NHANES cross sectional study of aspirin and fractures in the elderly. ( Abbas, KS; Abouainain, Y; Ahmad, EMS; Albuni, MK; Battikh, E; El-Sakka, AA; Elkalagi, NKH; Hafez, W; Lee, KY; Rakab, A; Sawaf, B; Swed, S, 2023) |
| "Aspirin has been reported to reduce bone fragility and slow bone loss." | 3.11 | Daily Low-Dose Aspirin and Risk of Serious Falls and Fractures in Healthy Older People: A Substudy of the ASPREE Randomized Clinical Trial. ( Barker, AL; Cumming, RG; Ebeling, PR; Hussain, SM; Khosla, S; McNeil, JJ; Morello, R; Newman, AB; Pasco, JA; Ronaldson, K; Sanders, KM; Seeman, E; Thao, LTP; Ward, SA; Williamson, JD; Wolfe, R; Woods, RL, 2022) |
| "Only aspirin use was significantly associated with intracranial bleed (p=0." | 1.43 | The older they are the harder they fall: Injury patterns and outcomes by age after ground level falls. ( Bhattacharya, B; Davis, KA; Maung, A; Schuster, K, 2016) |
| " Facilitation of osteoblast apoptosis occurred regardless of IND dosage under hypoxic conditions." | 1.38 | Facilitation of human osteoblast apoptosis by sulindac and indomethacin under hypoxic injury. ( Chang, CH; Chen, YC; Fan, SC; Huang, CH; Liu, C; Tsai, AL; Wu, CC, 2012) |
| "For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1." | 1.33 | Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2006) |
| " These animals were then assigned randomly to dose groups (1, 2 or 4 mg/kg/day of indomethacin and 100, 200, or 300 mg/kg/day of aspirin) and were dosed for 21 days." | 1.26 | Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat. ( Allen, HL; Bear, WT; Wase, A, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (31.71) | 18.7374 |
| 1990's | 1 (2.44) | 18.2507 |
| 2000's | 2 (4.88) | 29.6817 |
| 2010's | 7 (17.07) | 24.3611 |
| 2020's | 18 (43.90) | 2.80 |
| Authors | Studies |
|---|---|
| Barker, AL | 3 |
| Morello, R | 1 |
| Thao, LTP | 1 |
| Seeman, E | 3 |
| Ward, SA | 3 |
| Sanders, KM | 3 |
| Cumming, RG | 3 |
| Pasco, JA | 2 |
| Ebeling, PR | 3 |
| Woods, RL | 2 |
| Wolfe, R | 2 |
| Khosla, S | 3 |
| Hussain, SM | 1 |
| Ronaldson, K | 1 |
| Newman, AB | 1 |
| Williamson, JD | 1 |
| McNeil, JJ | 3 |
| Slomski, A | 1 |
| O'Toole, RV | 4 |
| Stein, DM | 4 |
| O'Hara, NN | 4 |
| Frey, KP | 1 |
| Taylor, TJ | 1 |
| Scharfstein, DO | 1 |
| Carlini, AR | 1 |
| Sudini, K | 1 |
| Degani, Y | 2 |
| Slobogean, GP | 3 |
| Haut, ER | 1 |
| Obremskey, W | 1 |
| Firoozabadi, R | 1 |
| Bosse, MJ | 1 |
| Goldhaber, SZ | 1 |
| Marvel, D | 1 |
| Castillo, RC | 2 |
| Costa, M | 1 |
| Swed, S | 1 |
| El-Sakka, AA | 1 |
| Abouainain, Y | 1 |
| Lee, KY | 1 |
| Sawaf, B | 1 |
| Albuni, MK | 1 |
| Battikh, E | 1 |
| Ahmad, EMS | 1 |
| Elkalagi, NKH | 1 |
| Abbas, KS | 1 |
| Hafez, W | 1 |
| Rakab, A | 1 |
| Stengel, D | 1 |
| Renkawitz, T | 1 |
| Sourmelis, S | 1 |
| Zagoreos, N | 1 |
| Wu, XD | 1 |
| Min, J | 1 |
| Yoshino, T | 1 |
| Yamada, Y | 1 |
| Tamura, Y | 1 |
| Ahuja, T | 1 |
| Green, D | 1 |
| van Twist, DJL | 1 |
| Luu, IHY | 1 |
| Ten Cate, H | 1 |
| Griffin, M | 1 |
| Lip, GYH | 1 |
| Ebell, MH | 1 |
| Soh, SE | 1 |
| Pasco, J | 1 |
| Peeters, G | 1 |
| Talevski, J | 2 |
| Haac, BE | 2 |
| Manson, TT | 2 |
| Masic, D | 1 |
| Kwon, O | 1 |
| Rech, MA | 1 |
| Liyanapthirana, C | 1 |
| Neal, R | 1 |
| Iordanov, T | 1 |
| Nahhas, A | 1 |
| Van Besien, R | 1 |
| Johal, H | 1 |
| Berger, PZ | 1 |
| Reahl, GB | 1 |
| Marinos, D | 1 |
| Mascarenhas, D | 1 |
| Connelly, D | 1 |
| Scalea, TM | 1 |
| El-Daly, I | 1 |
| Reidy, J | 1 |
| Culpan, P | 1 |
| Bates, P | 1 |
| Bohensky, MA | 1 |
| Lockery, JE | 1 |
| Bhattacharya, B | 1 |
| Maung, A | 1 |
| Schuster, K | 1 |
| Davis, KA | 1 |
| Blackhurst, H | 1 |
| Vestergaard, P | 2 |
| Steinberg, TH | 1 |
| Schwarz, P | 1 |
| Jørgensen, NR | 1 |
| Liu, C | 1 |
| Tsai, AL | 1 |
| Chen, YC | 1 |
| Fan, SC | 1 |
| Huang, CH | 1 |
| Wu, CC | 1 |
| Chang, CH | 1 |
| BOYLE, RW | 1 |
| TABET, RC | 1 |
| WIGHTMAN, BK | 1 |
| Rejnmark, L | 1 |
| Mosekilde, L | 1 |
| Bengmark, S | 1 |
| Göransson, G | 1 |
| Zoucas, E | 1 |
| Allen, HL | 1 |
| Wase, A | 1 |
| Bear, WT | 1 |
| Bauer, DC | 1 |
| Orwoll, ES | 1 |
| Fox, KM | 1 |
| Vogt, TM | 1 |
| Lane, NE | 1 |
| Hochberg, MC | 1 |
| Stone, K | 1 |
| Nevitt, MC | 1 |
| Shier, MR | 1 |
| Wilson, RF | 1 |
| James, RE | 1 |
| Riddle, J | 1 |
| Mammen, EF | 1 |
| Pedersen, HE | 1 |
| Lavrinovitsch, TS | 1 |
| Petuchova, LI | 1 |
| Slutskii, LI | 2 |
| Lavrinovich, TS | 1 |
| Petukhova, LI | 1 |
| Mehta, SD | 1 |
| Andrish, JT | 1 |
| Bergfeld, JA | 1 |
| Walheim, J | 1 |
| Lyon, LJ | 1 |
| Nevins, MA | 1 |
| Doutre, LP | 1 |
| Périssat, J | 1 |
| Spängler, P | 1 |
| Staffen, A | 1 |
| Schürer-Waldheim, H | 1 |
| Arcadio, AF | 1 |
| Mazenod, B | 1 |
| Milinkovitch, P | 1 |
| Moulary, A | 1 |
| Vailati, G | 1 |
| Montini, M | 1 |
| Bonicelli, A | 1 |
| Pagani, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aspirin in Reducing Events in the Elderly[NCT01038583] | 19,114 participants (Actual) | Observational | 2010-01-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for aspirin and Bone Fractures
| Article | Year |
|---|---|
Aspirin and fracture risk: a systematic review and exploratory meta-analysis of observational studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bone Density; Bone Density Conservation Agents; Fr | 2020 |
Thromboprophylaxis in patients with pelvic and acetabular fractures: A short review and recommendations.
Topics: Acetabulum; Anticoagulants; Aspirin; Benzimidazoles; beta-Alanine; Coumarins; Dabigatran; Fondaparin | 2013 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 1. Flight deep vein thrombosis prophylaxis in lower limb injury.
Topics: Aerospace Medicine; Anticoagulants; Aspirin; Evidence-Based Medicine; Fractures, Bone; Heparin; Huma | 2009 |
Prevention of thromboembolism after hip fracture.
Topics: Aged; Anticoagulants; Aspirin; Bandages; Coumarins; Dextrans; Exercise Therapy; Femoral Neck Fractur | 1973 |
9 trials available for aspirin and Bone Fractures
| Article | Year |
|---|---|
Daily Low-Dose Aspirin and Risk of Serious Falls and Fractures in Healthy Older People: A Substudy of the ASPREE Randomized Clinical Trial.
Topics: Aged; Aspirin; Australia; Female; Fractures, Bone; Humans; Independent Living; Male | 2022 |
Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis after a Fracture.
Topics: Adult; Anticoagulants; Aspirin; Chemoprevention; Extremities; Fractures, Bone; Hemorrhage; Heparin, | 2023 |
Aspirin does not reduce fracture and fall risk in healthy older people.
Topics: Accidental Falls; Aged; Aspirin; Fractures, Bone; Humans | 2023 |
Aspirin versus low-molecular-weight heparin for venous thromboembolism prophylaxis in orthopaedic trauma patients: A patient-centered randomized controlled trial.
Topics: Adult; Aged; Anticoagulants; Aspirin; Enoxaparin; Female; Fibrinolytic Agents; Fractures, Bone; Hemo | 2020 |
Post-discharge adherence with venous thromboembolism prophylaxis after orthopedic trauma: Results from a randomized controlled trial of aspirin versus low molecular weight heparin.
Topics: Adult; Aspirin; Female; Fibrinolytic Agents; Follow-Up Studies; Fractures, Bone; Heparin, Low-Molecu | 2018 |
A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: protocol for the ASPREE-Fracture substudy.
Topics: Accidental Falls; Activities of Daily Living; Aged; Aspirin; Australia; Cyclooxygenase Inhibitors; D | 2016 |
Aspirin and NSAID use in older women: effect on bone mineral density and fracture risk. Study of Osteoporotic Fractures Research Group.
Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bone Density; Female; Fractures, Bo | 1996 |
Fat embolism prophylaxis: a study of four treatment modalities.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Carbon Dioxide; Dextrans; Embolism, Fat; Factor V; Fibr | 1977 |
A randomized double-blind placebo-controlled study of dipyrone and aspirin in post-operative orthopaedic patients.
Topics: Adult; Aminopyrine; Aspirin; Clinical Trials as Topic; Dipyrone; Double-Blind Method; Female; Fractu | 1986 |
28 other studies available for aspirin and Bone Fractures
| Article | Year |
|---|---|
Low-Dose Aspirin Does Not Appear to Reduce Fractures.
Topics: Aspirin; Fractures, Bone; Humans; Platelet Aggregation Inhibitors | 2023 |
Thromboprophylaxis after Extremity Fracture - Time for Aspirin?
Topics: Anticoagulants; Aspirin; Chemoprevention; Extremities; Fractures, Bone; Humans; Pulmonary Embolism; | 2023 |
NHANES cross sectional study of aspirin and fractures in the elderly.
Topics: Aged; Aged, 80 and over; Aspirin; Bone Density; Cross-Sectional Studies; Female; Fractures, Bone; Hi | 2023 |
[Low-dose aspirin vs. low molecular weight heparin for thromboprophylaxis after fractures : Critical appraisal of the multicenter PREVENT CLOT trial conducted by the Major Extremity Trauma Research Consortium (METRC)].
Topics: Anticoagulants; Aspirin; Extremities; Fractures, Bone; Heparin, Low-Molecular-Weight; Humans; Treatm | 2023 |
Aspirin for Thromboprophylaxis after a Fracture.
Topics: Anticoagulants; Aspirin; Fractures, Bone; Heparin, Low-Molecular-Weight; Humans; Pulmonary Embolism; | 2023 |
Aspirin for Thromboprophylaxis after a Fracture.
Topics: Anticoagulants; Aspirin; Fractures, Bone; Heparin, Low-Molecular-Weight; Humans; Pulmonary Embolism; | 2023 |
Aspirin for Thromboprophylaxis after a Fracture.
Topics: Anticoagulants; Aspirin; Fractures, Bone; Heparin, Low-Molecular-Weight; Humans; Pulmonary Embolism; | 2023 |
Aspirin for Thromboprophylaxis after a Fracture.
Topics: Anticoagulants; Aspirin; Fractures, Bone; Heparin, Low-Molecular-Weight; Humans; Pulmonary Embolism; | 2023 |
Aspirin for Thromboprophylaxis after a Fracture.
Topics: Anticoagulants; Aspirin; Fractures, Bone; Heparin, Low-Molecular-Weight; Humans; Pulmonary Embolism; | 2023 |
Aspirin for Thromboprophylaxis after a Fracture. Reply.
Topics: Anticoagulants; Aspirin; Fractures, Bone; Heparin, Low-Molecular-Weight; Humans; Pulmonary Embolism; | 2023 |
In limb or pelvic fracture, aspirin was noninferior to enoxaparin for reducing all-cause death.
Topics: Anticoagulants; Aspirin; Enoxaparin; Extremities; Fractures, Bone; Humans; Venous Thromboembolism | 2023 |
Twice-Daily Low-Dose Aspirin Is Similar to Enoxaparin for Thromboprophylaxis After Inpatient Treatment for Fracture.
Topics: Anticoagulants; Aspirin; Enoxaparin; Fractures, Bone; Humans; Inpatients; Venous Thromboembolism | 2023 |
Desmopressin with four-factor prothrombin complex concentrate for life-threatening bleeding: A case series.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Blood Coagulation Factors; Cerebral Hemorrhage, Tr | 2020 |
A rare consequence of very common osteoporotic pubic rami fracture in a patient with myeloproliferative disease.
Topics: Accidental Falls; Aged, 80 and over; Aspirin; Blood Transfusion; Female; Fractures, Bone; Hematoma; | 2017 |
The older they are the harder they fall: Injury patterns and outcomes by age after ground level falls.
Topics: Accidental Falls; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Comorbidity; Female; Follow-Up S | 2016 |
Use of the oral platelet inhibitors dipyridamole and acetylsalicylic acid is associated with increased risk of fracture.
Topics: Acute Coronary Syndrome; Adult; Aged; Aspirin; Case-Control Studies; Clopidogrel; Dipyridamole; Drug | 2012 |
Facilitation of human osteoblast apoptosis by sulindac and indomethacin under hypoxic injury.
Topics: Alkaline Phosphatase; Animals; Apoptosis; Aspirin; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Ce | 2012 |
ANALGESIC EFFECT OF PRODILIDINE HYDROCHLORIDE (5054) IN ELDERLY PATIENTS WITH CHRONIC PAIN SYNDROME.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Arthritis; Arthritis, Rheumatoid; Aspirin; Chron | 1964 |
Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; | 2006 |
Trauma an acetylsalicylic acid-induced changes in hemostasis during liver resection in the rat.
Topics: Animals; Aspirin; Bleeding Time; Blood Coagulation; Fractures, Bone; Hemostasis; Leg; Liver; Male; R | 1980 |
Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat.
Topics: Animals; Aspirin; Cartilage; Dose-Response Relationship, Drug; Fractures, Bone; Indomethacin; Male; | 1980 |
[A comparative investigation of acetylsalicyclic acid and indirect anticoagulants for the prophylaxis of venous thromboses in patients with an orthopedic-traumatologic case history (author's transl)].
Topics: Aspirin; Female; Fractures, Bone; Humans; Male; Middle Aged; Osteotomy; Phenindione; Postoperative C | 1976 |
[Comparative evaluation of aspirin and indirect-action anticoagulants in the prevention of venous thromboses in traumatology and orthopedic practice].
Topics: Adult; Anticoagulants; Aspirin; Drug Evaluation; Female; Fractures, Bone; Hemorrhage; Humans; Male; | 1976 |
A prospective study on the management of shin splints.
Topics: Aspirin; Casts, Surgical; Fractures, Bone; Heel; Humans; Ice; Leg; Male; Naval Medicine; Pain; Pain | 1974 |
[Propofan as an antalgic in general surgery. Apropos of 50 cases].
Topics: Acetaminophen; Analgesics; Aspirin; Bone Diseases; Caffeine; Chlorpheniramine; Dextropropoxyphene; D | 1972 |
[Prevention of postoperative thromboembolism in patients with fractures in the region of the hip joint by the use of acetylsalicylic acid micropellets (author's transl)].
Topics: Aspirin; Coumarins; Drug Synergism; Female; Femoral Fractures; Fractures, Bone; Hip; Hip Joint; Huma | 1973 |
[Value of lysine acetylsalicylate in pains of traumatic origin (apropos of 86 cases)].
Topics: Adolescent; Adult; Aged; Analgesics; Aspirin; Child; Fractures, Bone; Humans; Joint Dislocations; Ly | 1972 |
[Clinical-experimental study of lysine acetylsalicylate].
Topics: Adolescent; Adult; Aged; Aspirin; Blood Coagulation; Bone Neoplasms; Female; Fever; Fractures, Bone; | 1971 |