aspirin has been researched along with Blood Poisoning in 56 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "ANTISEPSIS was a substudy of ASPREE (a randomised controlled primary prevention trial of low-dose aspirin [100 mg per day] compared with placebo in community dwelling older adults conducted in Australia and the USA), with the Australian cohort included in the ANTISEPSIS substudy." | 9.41 | Effect of aspirin on deaths associated with sepsis in healthy older people (ANTISEPSIS): a randomised, double-blind, placebo-controlled primary prevention trial. ( Eisen, DP; Leder, K; Lockery, JE; McBryde, ES; McGuinness, SL; McNeil, JJ; Moore, EM; Nelson, MR; Pilcher, D; Reid, CM; Shastry, A; Wolfe, R; Woods, RL, 2021) |
| " There are indications from experimental and observational studies that aspirin may reduce inflammation associated with infection." | 9.24 | AspiriN To Inhibit SEPSIS (ANTISEPSIS) randomised controlled trial protocol. ( Eisen, DP; Leder, K; Lockery, J; McBryde, ES; McNeil, JJ; Moore, EM; Pilcher, D; Wolfe, R; Woods, RL, 2017) |
| "It has been suggested that aspirin may be of benefit in treating sepsis and ARDS in view of its ability to block cyclo-oxygenase-1 (COX-1) and COX-2 activities; inhibit nuclear factor kappa B (NF-κB); enhance the production of endothelial nitric oxide (eNO) and lipoxin A4 (LXA4)." | 8.93 | Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS. ( Das, UN, 2016) |
| "We conducted a retrospective population-based cohort study using the National Health Insurance Research Database of Taiwan from 2001 to 2011 to examine the relationship between aspirin use before hospital admission and sepsis outcomes." | 8.12 | Association Between Aspirin Use and Sepsis Outcomes: A National Cohort Study. ( Chang, IJ; Dao, QL; Hsu, TC; Hsu, WT; Lee, CC; Porta, L; Tehrani, BM, 2022) |
| "In the REGARDS cohort, baseline aspirin use was not associated with long-term rates of sepsis." | 7.88 | Aspirin use and long-term rates of sepsis: A population-based cohort study. ( Chaudhary, NS; Donnelly, JP; Hsu, J; Kim, J; Moore, JX; Safford, MM; Wang, HE, 2018) |
| " A multivariable analysis including age, gender, current tobacco use, prehospital aspirin use, race, and Acute Physiology and Chronic Health Evaluation II score revealed that patients on statin therapy before hospitalization were less likely to have or develop severe sepsis (odds ratio 0." | 7.77 | Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. ( Bernard, GR; Curtis, BR; Fremont, RD; Koehler, EA; Koyama, T; May, AK; O'Neal, HR; Siew, E; Ware, LB, 2011) |
| "Sepsis is a common condition that is associated with significant morbidity, mortality and health-care cost." | 6.52 | Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome. ( McAuley, DF; Shyamsundar, M; Toner, P, 2015) |
| "Sepsis is an inflammatory condition associated with significant morbidity and mortality." | 6.48 | Do aspirin and statins prevent severe sepsis? ( O'Neal, HR; Sanchez, MA; Thomas, CB, 2012) |
| "Postoperative acute lung injury is associated with a higher risk of lung metastasis." | 5.91 | Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration. ( Fukuda, K; Hirahashi, J; Kawakubo, H; Kitagawa, Y; Kobayashi, R; Matsuda, S; Matsui, K; Nakamura, R; Nishimura, E; Okubo, K; Takeuchi, M, 2023) |
| "ANTISEPSIS was a substudy of ASPREE (a randomised controlled primary prevention trial of low-dose aspirin [100 mg per day] compared with placebo in community dwelling older adults conducted in Australia and the USA), with the Australian cohort included in the ANTISEPSIS substudy." | 5.41 | Effect of aspirin on deaths associated with sepsis in healthy older people (ANTISEPSIS): a randomised, double-blind, placebo-controlled primary prevention trial. ( Eisen, DP; Leder, K; Lockery, JE; McBryde, ES; McGuinness, SL; McNeil, JJ; Moore, EM; Nelson, MR; Pilcher, D; Reid, CM; Shastry, A; Wolfe, R; Woods, RL, 2021) |
| " Consequently, dosing regimens for this compound may not need to be altered in sepsis." | 5.30 | Influence of sepsis on the plasma elimination pharmacokinetics of diaspirin crosslinked hemoglobin in rats. ( Chin-Yee, IH; d'Almeida, MS; Sibbald, WJ; White, M, 1998) |
| " There are indications from experimental and observational studies that aspirin may reduce inflammation associated with infection." | 5.24 | AspiriN To Inhibit SEPSIS (ANTISEPSIS) randomised controlled trial protocol. ( Eisen, DP; Leder, K; Lockery, J; McBryde, ES; McNeil, JJ; Moore, EM; Pilcher, D; Wolfe, R; Woods, RL, 2017) |
| "Antiplatelet drugs, particularly aspirin, could be used to effectively reduce mortality in patients with sepsis." | 5.01 | Effects of antiplatelet therapy on the mortality rate of patients with sepsis: A meta-analysis. ( Ding, R; Liu, B; Ma, X; Ouyang, Y; Wang, Y, 2019) |
| "The primary objective was to conduct a meta-analysis on published observational cohort data describing the association between acetyl-salicylic acid (aspirin) use prior to the onset of sepsis and mortality in hospitalized patients." | 4.95 | Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching. ( Al Harbi, SA; Arabi, YM; Boyle, AJ; Cartin-Ceba, R; Chen, W; Chen, YT; Eisen, DP; Falcone, M; Gajic, O; Godsell, J; Gong, MN; Kor, D; Lösche, W; McAuley, DF; McBryde, ES; Muhi, S; O'Neal, HR; Osthoff, M; Otto, GP; Sossdorf, M; Trauer, J; Tsai, MJ; Valerio-Rojas, JC; van der Poll, T; Violi, F; Ware, L; Widmer, AF; Wiewel, MA; Winning, J, 2017) |
| "It has been suggested that aspirin may be of benefit in treating sepsis and ARDS in view of its ability to block cyclo-oxygenase-1 (COX-1) and COX-2 activities; inhibit nuclear factor kappa B (NF-κB); enhance the production of endothelial nitric oxide (eNO) and lipoxin A4 (LXA4)." | 4.93 | Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS. ( Das, UN, 2016) |
| "Aspirin treatment during the ICU stay was associated with a significantly reduced 28-day all-cause mortality, particularly in patients with SIRS symptoms but without sepsis." | 4.31 | Aspirin Therapy and 28-Day Mortality in ICU Patients: A Retrospective Observational Study From Two Large Databases. ( Guan, X; Li, B; Liu, Y; Liu, Z; Nie, Y; Pei, F; Wang, L; Wu, J; Zuo, L, 2023) |
| "We conducted a retrospective population-based cohort study using the National Health Insurance Research Database of Taiwan from 2001 to 2011 to examine the relationship between aspirin use before hospital admission and sepsis outcomes." | 4.12 | Association Between Aspirin Use and Sepsis Outcomes: A National Cohort Study. ( Chang, IJ; Dao, QL; Hsu, TC; Hsu, WT; Lee, CC; Porta, L; Tehrani, BM, 2022) |
| " Therapeutic strategies using lipid mediators, such as aspirin-triggered resolvin D1 (ATRvD1), can contribute to the resolution of acute and chronic inflammation." | 4.02 | ATRvD1 Attenuates Renal Tubulointerstitial Injury Induced by Albumin Overload in Sepsis-Surviving Mice. ( Almeida-Souza, F; Benjamim, CF; Calabrese, KS; Calcia, TBB; Caruso-Neves, C; Guilherme, RF; Lemos, FS; Neves, JS; Silva, CP; Silva, JBNF, 2021) |
| "In the REGARDS cohort, baseline aspirin use was not associated with long-term rates of sepsis." | 3.88 | Aspirin use and long-term rates of sepsis: A population-based cohort study. ( Chaudhary, NS; Donnelly, JP; Hsu, J; Kim, J; Moore, JX; Safford, MM; Wang, HE, 2018) |
| "Analyzing medical records of 979 patients with severe sepsis or septic shock provided some evidence that the use of low-dose aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) was associated with decreased hospital mortality." | 3.79 | Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients. ( Boettel, J; Lösche, W; Otto, GP; Sossdorf, M; Winning, J, 2013) |
| " A multivariable analysis including age, gender, current tobacco use, prehospital aspirin use, race, and Acute Physiology and Chronic Health Evaluation II score revealed that patients on statin therapy before hospitalization were less likely to have or develop severe sepsis (odds ratio 0." | 3.77 | Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. ( Bernard, GR; Curtis, BR; Fremont, RD; Koehler, EA; Koyama, T; May, AK; O'Neal, HR; Siew, E; Ware, LB, 2011) |
| " In this study, we demonstrate that sepsis induces insulin resistance and that pretreatment with aspirin inhibits sepsis-induced insulin resistance." | 3.72 | Aspirin inhibits serine phosphorylation of IRS-1 in muscle and adipose tissue of septic rats. ( Barreiro, GC; Caliseo, CT; Carvalheira, JB; Fugiwara, FY; Prada, PO; Prattali, RR; Saad, MJ; Ueno, M; Velloso, LA, 2004) |
| " There were five chronic alcoholics, one aspirin abuser, one severely burned patient, and one patient with sepsis." | 3.65 | Gastric devascularization: an alternate approach to the surgical treatment of massive, diffuse hemorrhage from gastritis. ( Aust, JB; McFee, AS; Rittenhouse, M, 1976) |
| "Aspirin therapy was not associated with a reduction in ICU mortality (adjusted OR 1." | 2.82 | Association between aspirin therapy and the outcome in critically ill patients: a nested cohort study. ( Al Harbi, SA; Al-Dorzi, HM; Arabi, YM; Sadat, M; Tamim, HM, 2016) |
| "Sepsis is a common condition that is associated with significant morbidity, mortality and health-care cost." | 2.52 | Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome. ( McAuley, DF; Shyamsundar, M; Toner, P, 2015) |
| "In need of innovative approach in the treatment of sepsis, further prospective, interventional, randomized trials are pivotal to establish potential use of antiplatelet agents in this context." | 2.50 | Use of antiplatelet agents in sepsis: a glimpse into the future. ( Akinosoglou, K; Alexopoulos, D, 2014) |
| "Sepsis is an inflammatory condition associated with significant morbidity and mortality." | 2.48 | Do aspirin and statins prevent severe sepsis? ( O'Neal, HR; Sanchez, MA; Thomas, CB, 2012) |
| "Postoperative acute lung injury is associated with a higher risk of lung metastasis." | 1.91 | Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration. ( Fukuda, K; Hirahashi, J; Kawakubo, H; Kitagawa, Y; Kobayashi, R; Matsuda, S; Matsui, K; Nakamura, R; Nishimura, E; Okubo, K; Takeuchi, M, 2023) |
| "Sepsis is a major health burden worldwide." | 1.43 | Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: a propensity-matched analysis. ( Bonten, MJ; Cremer, OL; de Stoppelaar, SF; Frencken, JF; Hoogendijk, AJ; Horn, J; Klein Klouwenberg, PMC; Schultz, MJ; van der Poll, T; van Vught, LA; Wiewel, MA; Zwinderman, AH, 2016) |
| "Vascular access-related infections and septicemia are the main causes of infections among hemodialysis patients, the majority of them caused by Staphylococcus species." | 1.42 | Association between acetylsalicylic acid and the risk of dialysis-related infections or septicemia among incident hemodialysis patients: a nested case-control study. ( Elftouh, N; Grinker, R; Harrak, H; Lafrance, JP; Laurin, LP; Normand, I, 2015) |
| "Atherosclerosis is considered as a moderate systemic inflammation and we hypothesise that this chronic condition could have an impact on the outcome in sepsis." | 1.39 | Effects of low-dose acetylsalicylic acid and atherosclerotic vascular diseases on the outcome in patients with severe sepsis or septic shock. ( Boettel, J; Breuel, H; Kabisch, B; Lösche, W; Otto, GP; Sossdorf, M; Winning, J, 2013) |
| "Histology showed typical wedge-shaped infarction in the affected organs with endothelial proliferation and occlusion by thrombus." | 1.35 | Degos' disease: a rare condition simulating rheumatic diseases. ( Chung, HY; Mok, MY; Trendell-Smith, NJ; Yeung, CK, 2009) |
| " Consequently, dosing regimens for this compound may not need to be altered in sepsis." | 1.30 | Influence of sepsis on the plasma elimination pharmacokinetics of diaspirin crosslinked hemoglobin in rats. ( Chin-Yee, IH; d'Almeida, MS; Sibbald, WJ; White, M, 1998) |
| "Aspirin did not cause any change in either the BUN concentration, its 15N enrichment, or any of the plasma amino acids." | 1.27 | The effect of aspirin on protein breakdown in septic man. ( Marino, PL; Miccolo, M; Novick, WM; Stein, TP, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (21.43) | 18.7374 |
| 1990's | 4 (7.14) | 18.2507 |
| 2000's | 6 (10.71) | 29.6817 |
| 2010's | 25 (44.64) | 24.3611 |
| 2020's | 9 (16.07) | 2.80 |
| Authors | Studies |
|---|---|
| Silva, JBNF | 1 |
| Calcia, TBB | 1 |
| Silva, CP | 1 |
| Guilherme, RF | 1 |
| Almeida-Souza, F | 1 |
| Lemos, FS | 1 |
| Calabrese, KS | 1 |
| Caruso-Neves, C | 1 |
| Neves, JS | 1 |
| Benjamim, CF | 1 |
| Hsu, WT | 1 |
| Porta, L | 1 |
| Chang, IJ | 1 |
| Dao, QL | 1 |
| Tehrani, BM | 1 |
| Hsu, TC | 1 |
| Lee, CC | 1 |
| Lavie, I | 1 |
| Lavie, M | 1 |
| Gafter-Gvili, A | 1 |
| Halperin, E | 1 |
| Abramovich-Yoffe, H | 1 |
| Avni, T | 1 |
| Nishimura, E | 1 |
| Fukuda, K | 1 |
| Matsuda, S | 1 |
| Kobayashi, R | 1 |
| Matsui, K | 1 |
| Takeuchi, M | 1 |
| Okubo, K | 1 |
| Hirahashi, J | 1 |
| Nakamura, R | 1 |
| Kawakubo, H | 1 |
| Kitagawa, Y | 1 |
| Wang, L | 1 |
| Li, B | 1 |
| Zuo, L | 1 |
| Pei, F | 1 |
| Nie, Y | 1 |
| Liu, Y | 1 |
| Liu, Z | 1 |
| Wu, J | 1 |
| Guan, X | 1 |
| Carestia, A | 1 |
| Davis, RP | 1 |
| Grosjean, H | 1 |
| Lau, MW | 1 |
| Jenne, CN | 1 |
| Ho-Tin-Noé, B | 1 |
| Annane, D | 1 |
| Eisen, DP | 5 |
| Leder, K | 2 |
| Woods, RL | 2 |
| Lockery, JE | 1 |
| McGuinness, SL | 1 |
| Wolfe, R | 2 |
| Pilcher, D | 2 |
| Moore, EM | 2 |
| Shastry, A | 1 |
| Nelson, MR | 1 |
| Reid, CM | 1 |
| McNeil, JJ | 2 |
| McBryde, ES | 4 |
| Iriye, BK | 1 |
| Gregory, KD | 1 |
| Saade, GR | 1 |
| Grobman, WA | 1 |
| Brown, HL | 1 |
| Trauer, J | 1 |
| Muhi, S | 1 |
| Al Harbi, SA | 2 |
| Arabi, YM | 2 |
| Boyle, AJ | 1 |
| Cartin-Ceba, R | 1 |
| Chen, W | 1 |
| Chen, YT | 1 |
| Falcone, M | 1 |
| Gajic, O | 1 |
| Godsell, J | 1 |
| Gong, MN | 1 |
| Kor, D | 1 |
| Lösche, W | 3 |
| McAuley, DF | 2 |
| O'Neal, HR | 3 |
| Osthoff, M | 1 |
| Otto, GP | 3 |
| Sossdorf, M | 3 |
| Tsai, MJ | 1 |
| Valerio-Rojas, JC | 1 |
| van der Poll, T | 2 |
| Violi, F | 1 |
| Ware, L | 1 |
| Widmer, AF | 1 |
| Wiewel, MA | 2 |
| Winning, J | 3 |
| Casey, JD | 1 |
| Semler, MW | 1 |
| Bastarache, JA | 1 |
| Hsu, J | 1 |
| Donnelly, JP | 1 |
| Chaudhary, NS | 1 |
| Moore, JX | 1 |
| Safford, MM | 1 |
| Kim, J | 1 |
| Wang, HE | 1 |
| Ouyang, Y | 1 |
| Wang, Y | 1 |
| Liu, B | 1 |
| Ma, X | 1 |
| Ding, R | 1 |
| Leijte, GP | 1 |
| Kiers, D | 1 |
| van der Heijden, W | 1 |
| Jansen, A | 1 |
| Gerretsen, J | 1 |
| Boerrigter, V | 1 |
| Netea, MG | 1 |
| Kox, M | 2 |
| Pickkers, P | 2 |
| Akinosoglou, K | 1 |
| Alexopoulos, D | 1 |
| Iskandar, MZ | 1 |
| Chong, V | 1 |
| Hutcheon, S | 1 |
| Harrak, H | 1 |
| Normand, I | 1 |
| Grinker, R | 1 |
| Elftouh, N | 1 |
| Laurin, LP | 1 |
| Lafrance, JP | 1 |
| Serebruany, VL | 1 |
| Toner, P | 1 |
| Shyamsundar, M | 1 |
| de Stoppelaar, SF | 1 |
| van Vught, LA | 1 |
| Frencken, JF | 1 |
| Hoogendijk, AJ | 1 |
| Klein Klouwenberg, PMC | 1 |
| Horn, J | 1 |
| Bonten, MJ | 1 |
| Zwinderman, AH | 1 |
| Cremer, OL | 1 |
| Schultz, MJ | 1 |
| Tamim, HM | 1 |
| Al-Dorzi, HM | 1 |
| Sadat, M | 1 |
| Kiers, HD | 1 |
| van der Heijden, WA | 1 |
| Riksen, NP | 1 |
| Das, UN | 1 |
| Alosh, M | 1 |
| Huque, MF | 1 |
| Bretz, F | 1 |
| D'Agostino, RB | 1 |
| Lockery, J | 1 |
| Chung, HY | 1 |
| Trendell-Smith, NJ | 1 |
| Yeung, CK | 1 |
| Mok, MY | 1 |
| Sarullo, FM | 1 |
| Americo, L | 1 |
| Accardo, S | 1 |
| Cicero, S | 1 |
| Schicchi, R | 1 |
| Schirò, M | 1 |
| Castello, A | 1 |
| Koyama, T | 1 |
| Koehler, EA | 1 |
| Siew, E | 1 |
| Curtis, BR | 1 |
| Fremont, RD | 1 |
| May, AK | 1 |
| Bernard, GR | 1 |
| Ware, LB | 1 |
| Somma, MM | 1 |
| Weinstock, PJ | 1 |
| Haslinger, V | 1 |
| Dietz, W | 1 |
| Bartsch, M | 1 |
| Simma, B | 1 |
| Sanchez, MA | 1 |
| Thomas, CB | 1 |
| Reid, D | 1 |
| Boettel, J | 2 |
| Kabisch, B | 1 |
| Breuel, H | 1 |
| DUPONT, V | 1 |
| MARGAIRAZ, A | 1 |
| GOGUEL, A | 1 |
| Barreiro, GC | 1 |
| Prattali, RR | 1 |
| Caliseo, CT | 1 |
| Fugiwara, FY | 1 |
| Ueno, M | 1 |
| Prada, PO | 1 |
| Velloso, LA | 1 |
| Saad, MJ | 1 |
| Carvalheira, JB | 1 |
| Camporota, L | 1 |
| Wyncoll, D | 1 |
| Neame, PB | 1 |
| Hirsh, J | 1 |
| Schultz, SC | 1 |
| Powell, CC | 1 |
| Bernard, E | 1 |
| Malcolm, DS | 1 |
| Sielenkämper, AW | 2 |
| Chin-Yee, IH | 3 |
| Martin, CM | 2 |
| Sibbald, WJ | 3 |
| d'Almeida, MS | 1 |
| White, M | 1 |
| Eichelbrönner, O | 1 |
| Madorin, SW | 1 |
| Creteur, J | 1 |
| Vincent, JL | 1 |
| Dalldorf, FG | 2 |
| Jennette, JC | 2 |
| Upton, GW | 1 |
| Tullar, JC | 1 |
| Rittenhouse, M | 1 |
| McFee, AS | 1 |
| Aust, JB | 1 |
| Matuschak, GM | 1 |
| Miccolo, M | 1 |
| Novick, WM | 1 |
| Marino, PL | 1 |
| Stein, TP | 1 |
| Torrey, SB | 1 |
| Henretig, F | 1 |
| Fleisher, G | 1 |
| Goldstein, RM | 1 |
| Ardire, A | 1 |
| Ludwig, S | 1 |
| Ruddy, R | 1 |
| Miller, GC | 1 |
| Witham, AC | 1 |
| Niklasson, PM | 1 |
| Blombäck, M | 1 |
| Lundbergh, P | 1 |
| Strandell, T | 1 |
| Dacie, JV | 1 |
| Bray, B | 1 |
| Dehorne, M | 1 |
| Guimbretière, J | 1 |
| Muchmore, HG | 1 |
| Venters, HD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Randomized, Double-blind, Placebo-controlled, Clinical Trial of Acetylsalicylic Acid in the Prevention of Severe SARS-CoV2 Pneumonia in Hospitalised Patients (Asperum)[NCT04808895] | Phase 3 | 204 participants (Anticipated) | Interventional | 2021-04-01 | Not yet recruiting | ||
| The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury[NCT01659307] | Phase 2 | 33 participants (Anticipated) | Interventional | 2012-09-30 | Completed | ||
| ASpirin as a Treatment for ARDS (STAR): a Phase 2 Randomised Control Trial[NCT02326350] | Phase 2 | 49 participants (Actual) | Interventional | 2015-02-06 | Terminated (stopped due to Slow recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for aspirin and Blood Poisoning
| Article | Year |
|---|---|
Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching.
Topics: Aged; Aspirin; Female; Humans; Male; Middle Aged; Observational Studies as Topic; Platelet Aggregati | 2017 |
Effects of antiplatelet therapy on the mortality rate of patients with sepsis: A meta-analysis.
Topics: Aspirin; Critical Care; Drug Administration Schedule; Hospital Mortality; Humans; Intensive Care Uni | 2019 |
Use of antiplatelet agents in sepsis: a glimpse into the future.
Topics: Animals; Aspirin; Blood Platelets; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Pla | 2014 |
Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome.
Topics: Aspirin; Humans; Lung; Platelet Activation; Respiratory Distress Syndrome; Sepsis | 2015 |
Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome.
Topics: Aspirin; Humans; Lung; Platelet Activation; Respiratory Distress Syndrome; Sepsis | 2015 |
Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome.
Topics: Aspirin; Humans; Lung; Platelet Activation; Respiratory Distress Syndrome; Sepsis | 2015 |
Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome.
Topics: Aspirin; Humans; Lung; Platelet Activation; Respiratory Distress Syndrome; Sepsis | 2015 |
Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Drug Therapy, Combination; Eicos | 2016 |
Do aspirin and statins prevent severe sepsis?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Hydroxymethylglutaryl-CoA Reducta | 2012 |
Manifold beneficial effects of acetyl salicylic acid and nonsteroidal anti-inflammatory drugs on sepsis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; Dose-Response Rel | 2012 |
Practical aspects of treatment with drotrecogin alfa (activated).
Topics: Adult; Aged; Anti-Infective Agents; APACHE; Aspirin; Child; Clinical Trials as Topic; Cost-Benefit A | 2007 |
Increased platelet destruction.
Topics: Aspirin; beta-Thromboglobulin; Blood Platelets; Bone Marrow; Cell Membrane; Cell Survival; Chromium | 1982 |
4 trials available for aspirin and Blood Poisoning
| Article | Year |
|---|---|
Effect of aspirin on deaths associated with sepsis in healthy older people (ANTISEPSIS): a randomised, double-blind, placebo-controlled primary prevention trial.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Australia; Double-Blind M | 2021 |
Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.
Topics: Adult; Aged; Aspirin; Dose-Response Relationship, Drug; Double-Blind Method; Endotoxemia; Endotoxins | 2019 |
Association between aspirin therapy and the outcome in critically ill patients: a nested cohort study.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Comorbidi | 2016 |
AspiriN To Inhibit SEPSIS (ANTISEPSIS) randomised controlled trial protocol.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antisepsis; Aspirin; Australia; Fe | 2017 |
43 other studies available for aspirin and Blood Poisoning
| Article | Year |
|---|---|
ATRvD1 Attenuates Renal Tubulointerstitial Injury Induced by Albumin Overload in Sepsis-Surviving Mice.
Topics: Acute Kidney Injury; Albumins; Animals; Aspirin; Biomarkers; Cytokines; Disease Models, Animal; Doco | 2021 |
Association Between Aspirin Use and Sepsis Outcomes: A National Cohort Study.
Topics: Aspirin; Cohort Studies; Humans; Platelet Aggregation Inhibitors; Retrospective Studies; Sepsis | 2022 |
Chronic aspirin use and survival following sepsis-A propensity-matched, observational cohort study.
Topics: Aspirin; Cardiovascular Diseases; Cohort Studies; Humans; Platelet Aggregation Inhibitors; Retrospec | 2022 |
Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration.
Topics: Acute Lung Injury; Animals; Aspirin; Humans; Inflammation; Lung; Lung Neoplasms; Mice; Neutrophil In | 2023 |
Aspirin Therapy and 28-Day Mortality in ICU Patients: A Retrospective Observational Study From Two Large Databases.
Topics: Aspirin; Critical Care; Humans; Intensive Care Units; Retrospective Studies; Sepsis; Systemic Inflam | 2023 |
Acetylsalicylic acid inhibits intravascular coagulation during Staphylococcus aureus-induced sepsis in mice.
Topics: Animals; Aspirin; Blood Coagulation; Disseminated Intravascular Coagulation; Mice; Mice, Inbred C57B | 2020 |
Acetylsalicylic acid to fight thrombosis in sepsis.
Topics: Animals; Aspirin; Blood Coagulation; Mice; Sepsis; Staphylococcus aureus; Thrombosis | 2020 |
Aspirin for the primary prevention of sepsis.
Topics: Aged; Aged, 80 and over; Antisepsis; Aspirin; Double-Blind Method; Humans; Primary Prevention; Sepsi | 2021 |
Quality measures in high-risk pregnancies: Executive Summary of a Cooperative Workshop of the Society for Maternal-Fetal Medicine, National Institute of Child Health and Human Development, and the American College of Obstetricians and Gynecologists.
Topics: Antibiotic Prophylaxis; Aspirin; Cesarean Section; Congresses as Topic; Female; Fetal Growth Retarda | 2017 |
Aspirin for Sepsis Prophylaxis: An Ounce of Prevention?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Sepsis | 2017 |
Aspirin use and long-term rates of sepsis: A population-based cohort study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Comorbidity; Female; Humans; | 2018 |
Acute spinal cord compression: a rare complication of dual antiplatelet therapy.
Topics: Acute Disease; Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Fatal Outcome; Female; Hematom | 2015 |
Association between acetylsalicylic acid and the risk of dialysis-related infections or septicemia among incident hemodialysis patients: a nested case-control study.
Topics: Aged; Aspirin; Case-Control Studies; Catheter-Related Infections; Female; Humans; Male; Platelet Agg | 2015 |
Ticagrelor shift from PLATO to PEGASUS: Vanished mortality benefit, excess cancer deaths, massive discontinuations, and overshooting target events.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Follow-Up Studies; Hemorrhage; Humans; Mor | 2015 |
Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: a propensity-matched analysis.
Topics: Aged; Aspirin; Biomarkers; Female; Humans; Intensive Care Units; Male; Middle Aged; Netherlands; Pla | 2016 |
Aspirin may improve outcome in sepsis by augmentation of the inflammatory response.
Topics: Aspirin; Humans; Platelet Aggregation Inhibitors; Sepsis | 2016 |
Tutorial on statistical considerations on subgroup analysis in confirmatory clinical trials.
Topics: Aspirin; Clopidogrel; Data Interpretation, Statistical; Humans; Models, Statistical; Myocardial Infa | 2017 |
Degos' disease: a rare condition simulating rheumatic diseases.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diagnosis, Differential; Fatal Outcome; Fem | 2009 |
Tako-tsubo cardiomyopathy observed in a patient with sepsis and transient hyperthyroidism.
Topics: Amlodipine; Anti-Bacterial Agents; Antihypertensive Agents; Antithyroid Agents; Aspirin; Echocardiog | 2009 |
Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome.
Topics: Acute Lung Injury; Aged; Aspirin; Cohort Studies; Cross-Sectional Studies; Female; Humans; Hydroxyme | 2011 |
Statins and sepsis: a magic bullet or just shooting blanks?
Topics: Acute Lung Injury; Aspirin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggrega | 2011 |
Salicylate intoxication with symptoms of septicaemia in a 17-month-old girl.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Critical Care; Diagnostic Errors; Dose-Response Re | 2011 |
Acetyl salicylic acid usage and mortality in critically ill patients with the systemic inflammatory response syndrome and sepsis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Critical Illness; Female; Hospital Mortality | 2012 |
Effects of low-dose acetylsalicylic acid and atherosclerotic vascular diseases on the outcome in patients with severe sepsis or septic shock.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Blood Coagulation; Clopidog | 2013 |
Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Dose-Response Relationship, Dru | 2013 |
[SOME EXAMPLES OF "PSEUDO-INFECTIOUS" PICTURES INDUCED BY DRUGS].
Topics: Adolescent; Anticonvulsants; Arsenicals; Aspirin; Barbiturates; Diagnosis, Differential; Drug Erupti | 1964 |
Aspirin inhibits serine phosphorylation of IRS-1 in muscle and adipose tissue of septic rats.
Topics: Adipose Tissue; Animals; Aspirin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mus | 2004 |
Diaspirin crosslinked hemoglobin (DCLHb) attenuates bacterial translocation in rats.
Topics: Animals; Aspirin; Bacteria; Biological Transport; Blood Substitutes; Depression, Chemical; Hemoglobi | 1995 |
Diaspirin crosslinked hemoglobin improves systemic oxygen uptake in oxygen supply-dependent septic rats.
Topics: Animals; Aspirin; Blood Gas Analysis; Blood Substitutes; Erythrocyte Transfusion; Erythrocytes; Hemo | 1997 |
Influence of sepsis on the plasma elimination pharmacokinetics of diaspirin crosslinked hemoglobin in rats.
Topics: Animals; Aspirin; Blood Substitutes; Half-Life; Hemoglobins; Male; Rats; Rats, Sprague-Dawley; Sepsi | 1998 |
Diaspirin cross-linked hemoglobin improves mucosal perfusion in the ileum of septic rats.
Topics: Animals; Arterioles; Aspirin; Blood Substitutes; Capillaries; Exchange Transfusion, Whole Blood; Hem | 2000 |
Hemoglobin solutions: an "all-in-one" therapeutic strategy in sepsis?
Topics: Animals; Aspirin; Blood Substitutes; Fluid Therapy; Hemoglobins; Humans; Polyethylene Glycols; Rats; | 2000 |
Fatal meningococcal septicemia.
Topics: Adolescent; Adrenal Glands; Adult; Aspirin; Female; Humans; Infant; Kidney; Lung; Meningococcal Infe | 1977 |
Experimental meningococcal septicemia. Effect of aspirin therapy.
Topics: Animals; Aspirin; Female; Fibrin; Kidney Glomerulus; Kidney Tubular Necrosis, Acute; Lung; Meningoco | 1978 |
Gastric devascularization: an alternate approach to the surgical treatment of massive, diffuse hemorrhage from gastritis.
Topics: Adult; Age Factors; Alcoholism; Aspirin; Burns; Child, Preschool; Female; Gastrectomy; Gastritis; Ga | 1976 |
Pseudosepsis syndrome, multiple-system organ failure, and chronic salicylate intoxication. Inhibition of regulatory eicosanoids?
Topics: Aspirin; Chronic Disease; Eicosanoids; Humans; Multiple Organ Failure; Sepsis; Syndrome | 1991 |
The effect of aspirin on protein breakdown in septic man.
Topics: Adult; Aged; Amino Acids; Aspirin; Blood Glucose; Blood Urea Nitrogen; Cyclooxygenase Inhibitors; Fe | 1986 |
Temperature response to antipyretic therapy in children: relationship to occult bacteremia.
Topics: Acetaminophen; Aspirin; Body Temperature; Child, Preschool; Fever; Haemophilus Infections; Haemophil | 1985 |
Delayed febrile pleuropericarditis after sepsis. A possible analogue of the postcardiotomy syndrome.
Topics: Adult; Aspirin; Blood Sedimentation; Cardiomegaly; Erythrocytes; Female; Fever; Heart Auscultation; | 1973 |
Thrombocytopenia and bleeding complications in severe cases of meningococcal infection treated with heparin, dextran 70 and chlorpromazine.
Topics: Adolescent; Adult; Aspirin; Blood Platelet Disorders; Cephalothin; Chlorpromazine; Dexamethasone; De | 1972 |
[Hemolytic-uremic syndrome and microangiopathic hemolytic anemia].
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic; Aspirin; Dextrans; Dipyridamole; Drug Hypersensitivity; | 1973 |
[Drug allergies and leukemias. Preliminary study].
Topics: Aged; Aminopyrine; Analgesics; Anti-Bacterial Agents; Antibodies; Antigen-Antibody Complex; Antigens | 1969 |
Purpura and septicemia due to Neisseria subflava.
Topics: Aspirin; Child; Humans; Male; Neisseria; Purpura; Sepsis; Sulfisoxazole | 1968 |