aspirin and Blood Loss, Postoperative studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

Excerpt	Relevance	Reference
"To evaluate the safety of preoperative use of ticagrelor with or without aspirin in patients with acute coronary syndromes (ACS) undergoing isolated coronary artery bypass grafting (CABG) compared with aspirin alone."	9.22	Safety of Preoperative Use of Ticagrelor With or Without Aspirin Compared With Aspirin Alone in Patients With Acute Coronary Syndromes Undergoing Coronary Artery Bypass Grafting. ( Bancone, C; Biancari, F; Chocron, S; Dalén, M; De Feo, M; Dominici, C; Faggian, G; Fischlein, T; Gatti, G; Gherli, R; Gherli, T; Gulbins, H; Kinnunen, EM; Mariscalco, G; Maschietto, L; Maselli, D; Mignosa, C; Musumeci, F; Nicolini, F; Onorati, F; Perrotti, A; Reichart, D; Rosato, S; Rubino, AS; Ruggieri, VG; Santarpino, G; Santini, F; Svenarud, P; Verhoye, JP; Zanobini, M, 2016)
"Rectal indomethacin has been proven to be effective for prevention of post-ERCP pancreatitis (PEP) but its impact on bleeding after biliary sphincterotomy (BABES) and cardiovascular mortality has not been extensively studied."	9.19	Does rectal indomethacin given for prevention of post-ERCP pancreatitis increase bleeding after biliary endoscopic sphincterotomy or cardiovascular mortality?: Post hoc analysis using prospective clinical trial data. ( Patai, Á; Patai, ÁV; Solymosi, N, 2014)
"Patients with a recently diagnosed ST-elevation myocardial infarction (STEMI) and implanted coronary drug-eluting stent (DES) who need urgent surgery are at increased risk of surgical bleeding unless aspirin and clopidogrel are discontinued beforehand."	9.17	Short-term follow-up of tirofiban as alternative therapy for urgent surgery patients with an implanted coronary drug-eluting stent after ST-elevation myocardial infarction. ( Liu, XH; Qu, Y; Shen, H; Xia, JG, 2013)
"To analyze the risk of postoperative bleeding following endoscopic endonasal transsphenoidal surgery (EETS) for treatment of pituitary adenomas (PA) in patients with short-term discontinuation of low-dose aspirin, if required for prevention of artherothrombotic disease (ATD)."	8.31	Management and risk of postoperative bleeding in patients with low-dose antiplatelet aspirin medication during endoscopic endonasal surgery for pituitary adenomas. ( Alhallak, M; Enciu, A; Gerlach, R; Kellner, G; Lauten, A; Loeschner, D; Meyer, A; Steinbrecher, A, 2023)
" Therefore, we investigated the risk of discontinuing aspirin concerning thrombotic complications in laparoscopic colorectal cancer surgery."	8.12	Impact of aspirin discontinuation on thrombotic complications in laparoscopic colorectal cancer surgery. ( Dono, K; Hamabe, A; Harino, T; Noura, S; Ogino, T; Suzuki, Y; Takeyama, H; Tanida, T; Tomita, N, 2022)
"In this single-center analysis of patients who received aspirin within 24 hours of CABG, postoperative thrombocytopenia was not associated with an increase in bleeding."	8.12	Impact of Thrombocytopenia on Postoperative Bleeding Incidence in Patients Receiving Aspirin Following Coronary Artery Bypass Grafting. ( Dobbins, KF; Henderson, JB; Hollis, IB; Rodino, AM; Rubin, DT, 2022)
" In this study, we evaluated the incidence of postoperative bleeding, hematoma formation, and wound dehiscence after perioperative aspirin ingestion before foot and ankle surgery."	7.91	Association of Aspirin Use With Postoperative Hematoma and Bleeding Complications in Foot and Ankle Surgery: A Retrospective Study. ( Hassan, MK; Karlock, LG, 2019)
"Symptomatic or asymptomatic deep vein thrombosis (DVT) is a common complication following coronary artery bypass graft (CABG), in which less than 1% of these patients suffer from clinically evident pulmonary embolism (PE)."	6.78	Comparison of aspirin plus heparin with heparin alone on asymptomatic perioperative deep vein thrombosis in candidates for elective off-pump coronary artery bypass graft: a randomized clinical trial. ( Ali-Hasan-Al-Saegh, S; Forouzannia, SK; Mirhosseini, SJ; Mostafavi Pour Manshadi, SM; Naderi, N; Sanatkar, M, 2013)
"In laparoscopic surgery for colorectal cancer (CRC) for patients who receive antiplatelet therapy (APT), it remains unclear whether APT should be continued or temporarily withdrawn."	5.62	Impact of perioperative aspirin continuation on bleeding complications in laparoscopic colorectal cancer surgery: a propensity score-matched analysis. ( Fujikawa, T; Takahashi, R, 2021)
"The rate of pulmonary embolism was 0."	5.37	The effect of aspirin and low-molecular-weight heparin on venous thromboembolism after hip replacement: a non-randomised comparison from information in the National Joint Registry. ( Charman, SC; Gregg, PJ; Jameson, SS; Reed, MR; van der Meulen, JH, 2011)
"The topic of aspirin (acetylsalicylic acid, ASA) use in coronary artery disease patients planned for coronary artery bypass grafting during perioperative period is among the most disputed issues in cardiac surgery."	5.27	Effect of Sustained Use of Aspirin until the Time of Surgery on Outcomes following Coronary Artery Bypass Grafting: A Randomized Clinical Trial. ( Ghandi, Y; Kamali, A; Sharifi, M, 2018)
"A systematic electronic search of the literature was performed using PubMed/MEDLINE, Scopus, and CENTRAL, to assess the risk of bleeding in patients who do not interrupt single antiplatelet therapy (P2Y12 inhibitors or aspirin) and undergone colonoscopy with polypectomy."	5.22	Risk of colonoscopic post-polypectomy bleeding in patients on single antiplatelet therapy: systematic review with meta-analysis. ( Fabiani, S; Latella, G; Longo, S; Magistroni, M; Mancusi, A; Romano, S; Stefanelli, G; Valvano, M; Vernia, F; Viscido, A, 2022)
"To evaluate the safety of preoperative use of ticagrelor with or without aspirin in patients with acute coronary syndromes (ACS) undergoing isolated coronary artery bypass grafting (CABG) compared with aspirin alone."	5.22	Safety of Preoperative Use of Ticagrelor With or Without Aspirin Compared With Aspirin Alone in Patients With Acute Coronary Syndromes Undergoing Coronary Artery Bypass Grafting. ( Bancone, C; Biancari, F; Chocron, S; Dalén, M; De Feo, M; Dominici, C; Faggian, G; Fischlein, T; Gatti, G; Gherli, R; Gherli, T; Gulbins, H; Kinnunen, EM; Mariscalco, G; Maschietto, L; Maselli, D; Mignosa, C; Musumeci, F; Nicolini, F; Onorati, F; Perrotti, A; Reichart, D; Rosato, S; Rubino, AS; Ruggieri, VG; Santarpino, G; Santini, F; Svenarud, P; Verhoye, JP; Zanobini, M, 2016)
"Rectal indomethacin has been proven to be effective for prevention of post-ERCP pancreatitis (PEP) but its impact on bleeding after biliary sphincterotomy (BABES) and cardiovascular mortality has not been extensively studied."	5.19	Does rectal indomethacin given for prevention of post-ERCP pancreatitis increase bleeding after biliary endoscopic sphincterotomy or cardiovascular mortality?: Post hoc analysis using prospective clinical trial data. ( Patai, Á; Patai, ÁV; Solymosi, N, 2014)
"Administration of aspirin before surgery and throughout the early postsurgical period had no significant effect on the rate of a composite of death or nonfatal myocardial infarction but increased the risk of major bleeding."	5.19	Aspirin in patients undergoing noncardiac surgery. ( Alonso-Coello, P; Amir, M; Baigent, C; Berwanger, O; Biccard, BM; Botto, F; Chan, MT; Chow, C; Chrolavicius, S; Cook, D; Devereaux, PJ; Eikelboom, J; Fleischmann, E; Forget, P; Gao, P; Garg, AX; Graham, M; Guyatt, G; Kearon, C; Kumar, PA; Kurz, A; Lamy, A; Le Manach, Y; Leslie, K; Lurati Buse, G; Malaga, G; Meyhoff, CS; Mizera, R; Mrkobrada, M; Paniagua, P; Parlow, JL; Pasin, L; Pettit, S; Pogue, J; Robinson, A; Rodseth, RN; Sessler, DI; Sigamani, A; Srinathan, S; Tiboni, M; Torres, D; VanHelder, T; Villar, JC; Wang, CY; Whitlock, R; Xavier, D; Yusuf, S, 2014)
"Patients with a recently diagnosed ST-elevation myocardial infarction (STEMI) and implanted coronary drug-eluting stent (DES) who need urgent surgery are at increased risk of surgical bleeding unless aspirin and clopidogrel are discontinued beforehand."	5.17	Short-term follow-up of tirofiban as alternative therapy for urgent surgery patients with an implanted coronary drug-eluting stent after ST-elevation myocardial infarction. ( Liu, XH; Qu, Y; Shen, H; Xia, JG, 2013)
"This randomized, double-blind, parallel-group, single-center trial involved patients with stable coronary artery disease who were assigned to receive either 300 mg of aspirin or placebo the night before coronary bypass surgery."	5.16	Effects of preoperative aspirin in coronary artery bypass grafting: a double-blind, placebo-controlled, randomized trial. ( Deja, MA; Domaradzki, W; Gaszewska-Żurek, E; Gocoł, R; Kargul, T; Mazur, W; Pytel, A; Stącel, T; Wojakowski, W; Woś, S; Żurek, P, 2012)
" The purpose of this study was to define the efficacy and safety of the agents that are currently used for prophylaxis against deep venous thrombosis -- namely, low-molecular-weight heparin, warfarin, aspirin, low-dose heparin, and pneumatic compression."	4.80	A meta-analysis of thromboembolic prophylaxis following elective total hip arthroplasty. ( Brookenthal, KR; Fitzgerald, RH; Freedman, KB; Lonner, JH; Williams, S, 2000)
"To analyze the risk of postoperative bleeding following endoscopic endonasal transsphenoidal surgery (EETS) for treatment of pituitary adenomas (PA) in patients with short-term discontinuation of low-dose aspirin, if required for prevention of artherothrombotic disease (ATD)."	4.31	Management and risk of postoperative bleeding in patients with low-dose antiplatelet aspirin medication during endoscopic endonasal surgery for pituitary adenomas. ( Alhallak, M; Enciu, A; Gerlach, R; Kellner, G; Lauten, A; Loeschner, D; Meyer, A; Steinbrecher, A, 2023)
" We aim to compare rates of postoperative bleeding, stroke and major adverse events (stroke, death or MI) among patients on Aspirin alone (ASAA) versus DAPT (Clopidogrel and Aspirin)."	4.31	Dual Antiplatelet Therapy Is Associated with Increased Risk of Bleeding and Decreased Risk of Stroke Following Carotid Endarterectomy. ( Dakour, H; Elsayed, N; Malas, MB; Marmor, R; Patel, RJ; Ramachandran, M, 2023)
"Replacement of thienopyridine with aspirin or cilostazol may be acceptable for minimizing both the risk of post-ESD bleeding and thromboembolism in patients with EGC."	4.31	Association between perioperative management of antiplatelet agents and risk of post-endoscopic submucosal dissection bleeding in early gastric cancer: analysis of a nationwide multicenter study. ( Asahina, Y; Fujishiro, M; Hasatani, K; Hatta, W; Hayashi, Y; Hikichi, T; Hoteya, S; Iguchi, M; Inoue, T; Kikuchi, D; Kiyotoki, S; Kobayashi, M; Kuribayashi, S; Mabe, K; Masamune, A; Matsumura, T; Michida, T; Mikami, T; Miura, Y; Morita, Y; Nagami, Y; Nakamatsu, D; Narasaka, T; Nebiki, H; Nishikawa, J; Ohnita, K; Sugimoto, M; Sumiyoshi, T; Suzuki, H; Tomida, H; Tsuji, S; Tsuji, Y; Ueyama, H; Yabuuchi, Y; Yada, T; Yamaguchi, S; Yoshio, T, 2023)
" Therefore, we investigated the risk of discontinuing aspirin concerning thrombotic complications in laparoscopic colorectal cancer surgery."	4.12	Impact of aspirin discontinuation on thrombotic complications in laparoscopic colorectal cancer surgery. ( Dono, K; Hamabe, A; Harino, T; Noura, S; Ogino, T; Suzuki, Y; Takeyama, H; Tanida, T; Tomita, N, 2022)
"In this single-center analysis of patients who received aspirin within 24 hours of CABG, postoperative thrombocytopenia was not associated with an increase in bleeding."	4.12	Impact of Thrombocytopenia on Postoperative Bleeding Incidence in Patients Receiving Aspirin Following Coronary Artery Bypass Grafting. ( Dobbins, KF; Henderson, JB; Hollis, IB; Rodino, AM; Rubin, DT, 2022)
"Previous studies have shown that aspirin is noninferior to other anticoagulation therapies in preventing postoperative venous thromboembolism following lower extremity arthroplasty or revision; however, its optimal dosing for this indication is less clear."	4.02	A Retrospective Analysis Comparing Post-Operative Bleeding with Various Doses of Aspirin after Lower Extremity Joint Arthroplasty or Revision. ( Cornett, B; Dziadkowiec, O; Harkness, W; Hassan, S; Hicks, ME; Jenkins, P; Kopstein, M; Scherbak, D; Watts, PJ, 2021)
"Management of patients treated with Ticagrelor is challenging, as stopping Ticagrelor prior to coronary bypass graft surgery (CABG) may increase the risk of acute stent thrombosis."	4.02	Coronary artery bypass graft surgery in patients on ticagrelor therapy is not associated with adverse perioperative outcomes. ( Amir, O; Arazi, M; Carasso, S; Diab, S; Grosman-Rimon, L; Kachel, E; Raanani, E; Shalabi, A; Sternik, L, 2021)
"Acetylsalicylic acid (ASA, aspirin) is a medication widely used for primary and secondary prevention of cardiovascular diseases, which are the leading cause of morbidity and mortality worldwide."	3.91	Aspirin for patients undergoing major lung resections: hazardous or harmless?†. ( Messerschmidt, A; Schneider, T; Stamenovic, D, 2019)
"The incidence of overall venous thromboembolism (VTE) within 90-day postsurgery was significantly higher in the aspirin cohort than it was in the rivaroxaban cohorts."	3.91	Clinical outcomes and risk factors of thromboprophylaxis with rivaroxaban versus aspirin in patients undergoing hip arthroplasty in low-incidence population: A nationwide study in Korea. ( Choi, KS; Kang, J; Kim, HA; Lee, JY; Park, SH; Rhie, SJ, 2019)
" In this study, we evaluated the incidence of postoperative bleeding, hematoma formation, and wound dehiscence after perioperative aspirin ingestion before foot and ankle surgery."	3.91	Association of Aspirin Use With Postoperative Hematoma and Bleeding Complications in Foot and Ankle Surgery: A Retrospective Study. ( Hassan, MK; Karlock, LG, 2019)
" The risk of readmission resulting from bleeding and venous thromboembolism (VTE) has also not been determined for patients undergoing THA or TKA when treated with low-molecular-weight heparin (LMWH) alone compared with mechanical prophylaxis plus aspirin (ASA)."	3.88	Mobile Compression Reduces Bleeding-related Readmissions and Wound Complications After THA and TKA. ( Arsoy, D; Giori, NJ; Woolson, ST, 2018)
" Clopidogrel in combination with aspirin, given before percutaneous coronary intervention, have become the standard for stent thrombosis prevention."	3.88	Impact of Clopidogrel Loading for Coronarography on Bleeding After Urgent First Time CABG. ( Deveja, R; Hoxha, A; Qirjazi, T; Shehu, S, 2018)
" We investigated use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), selective serotonin reuptake inhibitors (SSRIs), and statins and risk of postoperative red blood cell transfusion in breast cancer patients."	3.85	Use of prescription drugs and risk of postoperative red blood cell transfusion in breast cancer patients: a Danish population-based cohort study. ( Christiansen, PM; Cronin-Fenton, D; Erikstrup, C; Kristensen, NR; Møller, BK; Nørgaard, M; Pedersen, AB; Thomsen, AML, 2017)
" Among 614 participants with a preoperative diagnosis of coronary artery disease (CAD), in-hospital aspirin use was significantly higher in the contemporary period (66% vs 30."	3.83	Perioperative antiplatelet therapy and cardiovascular outcomes in patients undergoing joint and spine surgery. ( Berger, JS; Errico, T; Iorio, R; Nukala, S; Oberweis, BS; Radford, MJ; Rosenberg, A; Smilowitz, NR; Stuchin, S, 2016)
" Vorapaxar, a novel platelet thrombin receptor (PAR-1/4) blocker, is currently approved for post-myocardial infarction and peripheral artery disease indications on top of clopidogrel or/and aspirin."	3.83	Continued vorapaxar versus withdrawed clopidogrel both on top of low dose aspirin in patients undergoing heart surgery: A call for randomized trial. ( Bekbossynova, M; Cattaneo, M; Golukhova, E; Kim, MH; Marciniak, TA; Pya, Y; Serebruany, VL, 2016)
"To investigate the association between adenosine diphosphate (ADP)-induced platelet aggregation measured by single-platelet count testing and postoperative blood loss in clopidogrel-treated patients with acute coronary syndromes undergoing coronary artery bypass grafting (CABG)."	3.80	Adenosine diphosphate-induced single-platelet count aggregation and bleeding in clopidogrel-treated patients undergoing coronary artery bypass grafting. ( Dalén, M; Holm, M; Ivert, T; Lindvall, G; van der Linden, J, 2014)
"This case report discusses enucleation of a central dentigerous cyst in a 72-year old male on long-term low dose aspirin therapy."	3.78	Management of a dentigerous cyst in a medically compromised geriatric patient: a case report. ( Bains, R; Bains, VK; Loomba, A; Loomba, K, 2012)
"In this study, clopidogrel use during CEA resulted in a significant risk for developing a neck hematoma, particularly when using a Dacron-patch."	3.77	Outcomes related to antiplatelet or anticoagulation use in patients undergoing carotid endarterectomy. ( Alden, PB; Goldman, JA; Graber, JN; Rizvi, AZ; Rosenbaum, A; Sullivan, TM; Tretinyak, AS, 2011)
" clopidogrel) is known to be essential in patients in whom percutaneous coronary intervention with stent implantation has been performed in order to prevent stent thrombosis and its fatal consequences."	3.77	[Diagnostic laparoscopy under dual antiplatelet therapy with clopidogrel and aspirin]. ( Buerke, M; Mannes, F; Plehn, A; Schlitt, A; Vogt, A; Werdan, K; Wolf, HH, 2011)
"There seems no reasonable evidence that discontinuation of aspirin for carpal tunnel syndrome is justified."	3.76	Surgery for carpal tunnel syndrome under antiplatelet therapy. ( Bartels, RH; Boogaarts, HD; Verbeek, AL, 2010)
"A telephone questionnaire was undertaken to examine the current practice amongst 110 orthopaedic departments in the UK regarding the discontinuation of clopidogrel prior to trauma surgery for femoral neck fractures."	3.74	Is clopidogrel stopped prior to hip fracture surgery--A survey of current practice in the United Kingdom. ( Odutola, A; Palan, J; White, SP, 2007)
" The Safe and Timely Antithrombotic Removal - Ticagrelor (STAR-T) Trial is a multi-center, double-blind, randomized, controlled trial enrolling patients who require cardiothoracic surgery on cardiopulmonary bypass (CPB) within 48 hours of last ticagrelor dose."	3.11	Rationale and design of the safe and timely antithrombotic removal - ticagrelor (STAR-T) trial: A prospective, multi-center, double-blind, randomized controlled trial evaluating reductions in postoperative bleeding with intraoperative removal of ticagrelo ( Cutlip, DE; Deliargyris, EN; Doros, G; Gibson, CM; Kroger, H; Lee, VT; Mack, MJ; Ohman, EM; Schneider, DJ; Sellke, FW; Thourani, VH, 2022)
"For patients with inguinal hernias, laparoscopic TAPP repair is completely safe to be performed on those taking low-dose acetylsalicylic acid when it was only ceased on the operation day, with intravenous salvianolate given after the operation instead."	2.90	Continuation of low-dose acetylsalicylic acid during perioperative period of laparoscopic inguinal hernia repair is safe: results of a prospective clinical trial. ( Han, H; Liu, Y; Ruze, R; Wang, M; Xiong, Y; Yan, Z; Zhan, H; Zhang, G, 2019)
"And the postoperative hemorrhage and allogenic blood transfusion condition were observed and evaluated."	2.87	Preoperative antiplatelet drugs on the hemorrhage and allogenic blood transfusion condition after coronary artery bypass graft surgery. ( Chen, Y; Song, B; Wang, H; Zhu, P, 2018)
"Among 3,602 patients with STEMI who were enrolled in the HORIZONS-AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) trial, all ischemic and bleeding events, including recurrent events, were classified according to the timing of their occurrence as acute (≤24 h after PCI), subacute (1 day to 30 days), and late (30 days to 1 year)."	2.84	Characterization of the Average Daily Ischemic and Bleeding Risk After Primary PCI for STEMI. ( Brener, SJ; Dangas, GD; Deliargyris, EN; Généreux, P; Giustino, G; Kirtane, AJ; Mehran, R; Pocock, SJ; Prats, J; Redfors, B; Stone, GW, 2017)
"We aimed to explore whether risk of postoperative hemorrhage due to aspirin differs in the East and the West."	2.82	The risk of aspirin induced postoperative hemorrhage: a systematic review and meta-analysis. ( Chen, Y; Ding, Z; Han, C; Lin, R; Ling, X; Liu, J; Nie, C; Sheng, L, 2022)
"The rate of postoperative hemorrhage, average postoperative hemorrhage volume, and mortality rate were significantly higher in the ASA-sensitive patients who received ASA therapy compared with patients who did not receive ASA therapy (all p < 0."	2.78	Effect of acetylsalicylic acid usage and platelet transfusion on postoperative hemorrhage and activities of daily living in patients with acute intracerebral hemorrhage. ( Chen, J; Li, G; Li, X; Li, Y; Mao, J; Sun, Z; Xiang, Y; Yang, X; Ye, Y; Zhang, J; Zhang, M; Zhang, W; Zhao, J; Zhao, W, 2013)
"Symptomatic or asymptomatic deep vein thrombosis (DVT) is a common complication following coronary artery bypass graft (CABG), in which less than 1% of these patients suffer from clinically evident pulmonary embolism (PE)."	2.78	Comparison of aspirin plus heparin with heparin alone on asymptomatic perioperative deep vein thrombosis in candidates for elective off-pump coronary artery bypass graft: a randomized clinical trial. ( Ali-Hasan-Al-Saegh, S; Forouzannia, SK; Mirhosseini, SJ; Mostafavi Pour Manshadi, SM; Naderi, N; Sanatkar, M, 2013)
"The tranexamic acid regimen was a bolus of 10 mg/kg followed by a maintenance of 10 mg·kg(-1)·h(-1) throughout the surgery."	2.78	[Effectiveness and safety of tranexamic acid in patients receiving on-pump coronary artery bypass grafting without clopidogrel and aspirin cessation]. ( Li, LH; Shi, J; Wang, GY; Wang, YF; Xue, QH; Yuan, S, 2013)
"Treatment with aspirin resulted in a 7."	2.75	To continue or discontinue aspirin in the perioperative period: a randomized, controlled clinical trial. ( Darvish, B; Eintrei, C; Fredrikson, M; Gupta, A; Järhult, J; Krook, H; Nyström, M; Oscarsson, A; Pettersson, E; Swahn, E, 2010)
"Aspirin is a common, chronically administered preventive treatment for cardiovascular disease, but is often discontinued prior to invasive dental procedures because of concern for bleeding complications."	2.73	Aspirin use and post-operative bleeding from dental extractions. ( Brennan, MT; Fox, PC; Kent, ML; Lockhart, PB; Napeñas, JJ; Noll, JL; Sasser, HC; Valerin, MA, 2008)
"Aspirin pretreatment revealed no beneficial effects and resulted in increased postoperative bleeding and requirement for blood product transfusions after coronary artery bypass grafting in patients with stable angina."	2.71	Prediction of the excessive perioperative bleeding in patients undergoing coronary artery bypass grafting: role of aspirin and platelet glycoprotein IIIa polymorphism. ( Bochenek, A; Cisowski, M; Dropinski, J; Morawski, W; Sanak, M; Szczeklik, M; Szczeklik, W; Ulczok, R; Waclawczyk, T, 2005)
"Clopidogrel in combination with aspirin, given before percutaneous coronary intervention, has become the standard for stent thrombosis prevention."	2.70	The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting. ( Dick, SE; Hongo, RH; Ley, J; Yee, RR, 2002)
"As Aspirin (ASA) has proven efficacy in preventing patients with CAD from complications related to cardiovascular diseases, most patients scheduled for CABG are treated with ASA therapy."	2.69	Aprotinin counterbalances an increased risk of peri-operative hemorrhage in CABG patients pre-treated with Aspirin. ( Beckmann, H; Dauben, HP; Elert, O; Gams, E; Keith, PR; Klein, M; Mayer, G; Schulte, HD, 1998)
"Guidelines from the American Heart Association/American College of Cardiology recommend a higher dosage of aspirin daily following Percutaneous Coronary Intervention (PCI), whereas guidelines from the European Society of Cardiology recommend a lower dosage."	2.53	Adverse clinical outcomes associated with a low dose and a high dose of aspirin following percutaneous coronary intervention: a systematic review and meta-analysis. ( Bundhun, PK; Huang, WQ; Janoo, G; Teeluck, AR, 2016)
"It is essential to define/quantify the postoperative blood loss that precludes administration of early aspirin."	2.50	Who might benefit from early aspirin after coronary artery surgery? ( Bilkhu, R; Gukop, P; Gutman, N; Karapanagiotidis, GT, 2014)
" A survey of the currently available blood conservation techniques reveals 5 that stand out as reliable methods: 1) high-dose aprotinin therapy, 2) preoperative erythropoietin therapy when time permits adequate dosage before operation, 3) hemodilution by harvest of whole blood immediately before cardiopulmonary bypass, 4) autologous predonation of blood, and 5) salvage of oxygenator blood after cardiopulmonary bypass."	2.39	Limiting excessive postoperative blood transfusion after cardiac procedures. A review. ( Ferraris, SP; Ferraris, VA, 1995)
"Aspirin is a widely used drug for its analgetic, antiinflamatory and antipyretic effects as well as for prophylactic effect in cardiovascular diseases."	2.39	Aspirin, a silent risk factor in urology. ( Davidsen, MB; Meyhoff, HH; Zhu, JP, 1995)
"A history of postoperative hemorrhage (OR 1."	1.91	Risk Factors for Thromboembolic and Bleeding Events in Patients After the Fontan Operation (Insights from the National Database of Health Insurance Claims of Japan). ( Fujii, T; Hosoi, M; Kise, H; Kogo, M; Miyahara, Y; Ohbayashi, M, 2023)
"In laparoscopic surgery for colorectal cancer (CRC) for patients who receive antiplatelet therapy (APT), it remains unclear whether APT should be continued or temporarily withdrawn."	1.62	Impact of perioperative aspirin continuation on bleeding complications in laparoscopic colorectal cancer surgery: a propensity score-matched analysis. ( Fujikawa, T; Takahashi, R, 2021)
"Odds of venous thromboembolism were not statistically significant between all three study medications."	1.62	A retrospective analysis of bleeding risk with rivaroxaban, enoxaparin, and aspirin following total joint arthroplasty or revision. ( Cornett, B; Dziadkowiec, O; Harkness, W; Hassan, S; Hicks, ME; Kopstein, M; Scherbak, D; Watts, PJ, 2021)
"The risk of postoperative hemorrhage was compared in patients treated with ASA versus patients without ASA treatment."	1.62	Impact of acetylsalicylic acid (ASA) on postoperative hemorrhage in spinal lumbar surgery: Should preoperative ASA be discontinued for elective surgery? ( Leins, F; Luchtmann, M; Rashidi, A; Sandalcioglu, IE, 2021)
"Patients with acute coronary syndrome are treated with dual antiplatelet therapy containing acetylsalicylic acid (ASA) and P2Y12 antagonists."	1.56	Major Bleeding after Surgical Revascularization with Dual Antiplatelet Therapy. ( Choi, YH; Deppe, AC; Gerfer, S; Liakopoulos, O; Schlachtenberger, G; Wahlers, TCW; Zeriouh, M, 2020)
"A total of 597 patients with gastric neoplasms treated with ESD between January 2010 and June 2017 were enrolled."	1.51	Feasibility of gastric endoscopic submucosal dissection with continuous low-dose aspirin for patients receiving dual antiplatelet therapy. ( Amano, Y; Harada, H; Hayasaka, K; Katsuyama, Y; Murakami, D; Nagasaka, T; Nakahara, R; Sagami, R; Suehiro, S; Ujihara, T, 2019)
"Aspirin resistance was defined by a normal platelet function testing result for those who had continued taking aspirin until the day before the platelet function testing."	1.51	Aspirin Resistance Incidence and Associations Between Aspirin Effect and Outcomes in Cardiac Surgery. ( Ho, KM; Nicola, H, 2019)
"Warfarin treatment quality measured by iTTR as well as a medical history of anemia are strong independent predictors of bleeding in these patients."	1.48	Triple therapy after PCI - Warfarin treatment quality and bleeding risk. ( Englund, E; Jensen, J; Själander, A; Wadell, D, 2018)
"Postoperative hemorrhage was managed successfully by repacking with Gelfoam impregnated with tranexamic acid powder in most patients."	1.48	Management of dental extractions in patients on warfarin and antiplatelet therapy. ( Hsue, SS; Lin, LH; Lu, SY, 2018)
"Aspirin users were significantly older (P < 0."	1.46	Safety and feasibility of liver resection with continued antiplatelet therapy using aspirin. ( Hioki, M; Monden, K; Ohno, S; Ono, K; Sadamori, H; Sakaguchi, K; Saneto, H; Takakura, N; Ueki, T; Yabushita, K, 2017)
"All the patients presented with carotid artery stenosis >70% (North American Symptomatic Carotid Endarterectomy Trial [NASCET] criteria), which was symptomatic in 42 patients (transient ischemic attack, n = 32; minor stroke, n = 10) and asymptomatic in 146."	1.46	Dual Antiplatelet Therapy Does Not Increase the Risk of Bleeding After Carotid Endarterectomy: Results of a Prospective Study. ( Calio', FG; Illuminati, G; Masci, F; Pizzardi, G; Ricco, JB; Schneider, F, 2017)
"Aspirin was not associated with an increase in the rate of re-exploration for bleeding (5."	1.46	Preoperative Aspirin Does Not Increase Transfusion or Reoperation in Isolated Valve Surgery. ( Berguson, MW; Epstein, RH; Goldhammer, JE; Herman, CR; Sun, JZ; Torjman, MC, 2017)
"Hemoptysis was significantly more likely to occur in patients receiving acetylsalicylic acid (P=."	1.43	Bleeding Complications After Endoscopic Lung Volume Reduction Coil Treatment: A Retrospective Observational Study. ( Harbaum, L; Ittrich, H; Klose, H; Kluge, S; Oqueka, T; Simon, M, 2016)
"Aspirin has a proven role in preventing thrombotic diseases."	1.42	Does Early Post-operative Administration of Aspirin Influence the Risk of Bleeding After Coronary Artery Bypass Graft Surgery? A Prospective Observational Study. ( Emami Zeydi, A; Gholipour Baradari, A; Nouraei, SM, 2015)
"Incidences of symptomatic deep vein thrombosis (DVT) and PE, and major or minor bleeding complications were evaluated."	1.42	Clinical Performance of the 1st American Academy of Orthopaedic Surgeons Clinical Guideline on Prevention of Symptomatic Pulmonary Embolism after Total Knee Arthroplasty in Korean Patients. ( Cho, KJ; Fang, R; Kim, TK; Kim, YH; Na, YG, 2015)
"Because NSAID use also increases surgical blood loss, proper interval from discontinuation to surgery must be granted to minimize the risk."	1.40	Comparison of blood loss according to use of aspirin in lumbar fusion patients. ( Kwon, KY; Park, HJ; Woo, JH, 2014)
"The risk of postoperative hemorrhage following gastric ESD was higher in patients with antithrombotic therapy than in those without that therapy."	1.39	The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection. ( Edogawa, S; Harada, S; Higuchi, K; Kojima, Y; Ota, K; Takeuchi, T; Tokioka, S; Umegaki, E, 2013)
"The aspirin-treated group was significantly older, with higher weight and poorer health state (higher incidence of ischemic heart disease, cerebral ischemia and diabetes)."	1.38	[Low-dose aspirin doesn't increase surgical bleeding nor transfusion rate in total knee arthroplasty]. ( Bisbe Vives, E; Castillo Monsegur, J; López Bosque, R; Ruiz, A; Santiveri Papiol, X, 2012)
"Patients who underwent ESD for early gastric neoplasms at the National Cancer Center Hospital, Korea, between November 2008 and January 2011 were enrolled."	1.38	Aspirin use and bleeding risk after endoscopic submucosal dissection in patients with gastric neoplasms. ( Cho, SJ; Choi, IJ; Kim, CG; Kim, HJ; Kim, YW; Kwak, MH; Lee, JH; Lee, JY; Nam, BH; Ryu, KW, 2012)
"The rate of pulmonary embolism was 0."	1.37	The effect of aspirin and low-molecular-weight heparin on venous thromboembolism after hip replacement: a non-randomised comparison from information in the National Joint Registry. ( Charman, SC; Gregg, PJ; Jameson, SS; Reed, MR; van der Meulen, JH, 2011)
"Incidence of postoperative hemorrhage (early and delayed) was not significant (P = ."	1.37	Stopping anticoagulation before TURP does not appear to increase perioperative cardiovascular complications. ( Bariol, SV; Brooks, AJ; Drummond, M; Lau, HM; McDonald, C; Patel, MI; Raj, MD; Wang, AC; Woo, HH, 2011)
"Aspirin does not increase bleeding or increase the need for allogeneic blood transfusion in coronary artery surgery."	1.37	Aspirin does not increase bleeding and allogeneic blood transfusion in coronary artery surgery. ( Hijazi, E, 2011)
"Aspirin (ASA) has been shown to reduce postoperative coronary artery bypass grafting (CABG) mortality and ischemic events; however, the timing of chronic ASA discontinuation before surgery is controversial because of concern about postoperative bleeding."	1.37	Effect of timing of chronic preoperative aspirin discontinuation on morbidity and mortality in coronary artery bypass surgery. ( Blackstone, E; Cho, L; Jacob, M; Smedira, N; Williams, S, 2011)
"Surgical blood loss was measured, and the groups were compared for statistically significant differences in blood loss."	1.35	The effect of platelet-altering medications on bleeding from minor oral surgery procedures. ( Alvarado, F; Campbell, JH; Partridge, CG, 2008)
"Combined carotid stenting and cardiac surgery, performed in the same operating room under only heparin and aspirin, seems a safe and effective strategy for the treatment of patients with concomitant carotid and cardiac disease."	1.35	Safety and effectiveness of combining carotid artery stenting with cardiac surgery: preliminary results of a single-center experience. ( Capuano, F; Faraglia, V; Palombo, G; Rizzo, L; Sinatra, R; Stella, N; Taurino, M, 2009)
" All patient groups were similar regarding age, gender distribution, dosage of antiplatelet drug, and medical condition for which the drug was prescribed."	1.35	Exodontia and antiplatelet therapy. ( Alexander, M; Krishnan, B; Shenoy, NA, 2008)
"Aspirin was associated with a significantly higher risk of hyphaema (P=0."	1.34	The effect of aspirin and warfarin therapy in trabeculectomy. ( Chadha, V; Chakrabarti, S; Cobb, CJ; Sanders, R, 2007)
"Aspirin therapy was not an independent risk factor for bleeding."	1.34	Bleeding complications in skin cancer surgery are associated with warfarin but not aspirin therapy. ( Dixon, AJ; Dixon, JB; Dixon, MP, 2007)
"Study involved 75 patients (men) with ischemic heart disease, who underwent CABG."	1.33	[Influence of preoperative treatment with aspirin or heparin on platelet function and intensity of postoperative bleeding in early period after coronary artery bypass surgery]. ( Cimbolaityte, J; Grybauskas, P; Mongirdiene, A; Sirvinskas, E; Veikutiene, A; Veikutis, V, 2005)
"The incidence of significant postoperative hemorrhage in the aspirin and nonaspirin groups was 5 (1."	1.33	Surgical resection of cutaneous head and neck lesions: does aspirin use increase hemorrhagic risk? ( Dhiwakar, M; Khan, NA; McClymont, LG, 2006)
"Diagnoses included dilated cardiomyopathy (n = 15), myocarditis (n = 2), and postcardiotomy ventricular failure (n = 1)."	1.33	Ventricular assist device support in children and adolescents as a bridge to heart transplantation. ( Buchanan, JR; Gandhi, SK; Kormos, RL; Morell, VO; Sharma, MS; Wearden, PD; Webber, SA, 2006)
"The average postoperative blood loss (845 mL versus 775 mL; p = 0."	1.32	Effect of preoperative aspirin use in off-pump coronary artery bypass operations. ( Dihmis, WC; Fabri, BM; Grayson, AD; Pullan, DM; Srinivasan, AK, 2003)
"Early administration of a combined regimen of clopidogrel and aspirin following off-pump CABG is safe and is associated with a relatively low incidence of major adverse cardiac events, bleeding, PE, and DVT."	1.32	A feasibility study of the safety and efficacy of a combined clopidogrel and aspirin regimen following off-pump coronary artery bypass grafting. ( Benhameid, O; Endo, M; Shennib, H, 2003)
"Aspirine intake was not associated with an increase of bleeding or transfusion."	1.31	[Does the time between preoperative interruption of aspirin intake and operation influence postoperative blood loss and transfusion requirement in coronary artery bypass graft?]. ( Abdennadher, M; Blin, D; Chavanon, O; Cracowski, JL; Durand, M; Noirclerc, M; Protar, D; Romain-Sorin, V, 2002)
"Aspirin ingestion was correlated with postoperative blood transfusion using multivariate analysis."	1.31	Aspirin and postoperative bleeding after coronary artery bypass grafting. ( Ferraris, SP; Ferraris, VA; Joseph, O; Mentzer, RM; Wehner, P, 2002)
" There are doubts in case of emergency operations, especially in transplant patients, concerning dosage and change of medication."	1.30	[Preoperative aspirin therapy--a contraindication for kidney transplantation?]. ( Schubert, J; Werner, W, 1997)

Research

Studies (402)

Authors

Clinical Trials (34)

Trial Overview

Trial Outcomes

Number of Participants With BARC Type 2, 3, or 5

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	20 (4.98)	18.2507
2000's	105 (26.12)	29.6817
2010's	236 (58.71)	24.3611
2020's	41 (10.20)	2.80

Authors	Studies
Ndrepepa, G	2
Neumann, FJ	1
Menichelli, M	1
Holdenrieder, S	2
Richardt, G	1
Mayer, K	1
Cassese, S	2
Xhepa, E	1
Kufner, S	1
Wiebe, J	1
Joner, M	1
Kessler, T	1
Laugwitz, KL	1
Schunkert, H	2
Kastrati, A	3
Gibson, CM	2
Mack, MJ	1
Lee, VT	1
Schneider, DJ	1
Sellke, FW	1
Ohman, EM	2
Thourani, VH	2
Doros, G	1
Kroger, H	1
Cutlip, DE	1
Deliargyris, EN	2
Mishu, MD	1
Zolper, EG	1
Dekker, PK	1
Fleury, CM	1
Bekeny, JC	1
Fan, KL	1
Attinger, CE	1
Evans, KK	1
Valvano, M	1
Fabiani, S	1
Magistroni, M	1
Mancusi, A	1
Longo, S	1
Stefanelli, G	1
Vernia, F	1
Viscido, A	1
Romano, S	1
Latella, G	1
Harino, T	1
Noura, S	1
Hamabe, A	1
Ogino, T	1
Takeyama, H	1
Suzuki, Y	1
Tanida, T	1
Tomita, N	1
Dono, K	1
Wang, Z	3
Zou, Y	2
Xia, L	2
Li, X	4
Yao, Y	2
Ye, Y	3
Lv, Q	2
Horie, Y	1
Horiuchi, Y	1
Ishiyama, A	1
Tsuchida, T	1
Yoshimizu, S	1
Hirasawa, T	1
Fujisaki, J	2
Maetani, I	1
Yoshio, T	3
Patel, RJ	1
Marmor, R	1
Dakour, H	1
Elsayed, N	1
Ramachandran, M	1
Malas, MB	1
Xu, Q	1
Lau, LHS	1
Jiang, W	1
Guo, CLT	1
Lui, RN	1
Tang, RSY	1
Chan, FKL	1
Ling, X	1
Lin, R	1
Chen, Y	3
Nie, C	1
Sheng, L	1
Liu, J	1
Han, C	1
Ding, Z	1
Miura, Y	1
Tsuji, Y	3
Hatta, W	2
Yabuuchi, Y	2
Hoteya, S	2
Kikuchi, D	1
Tsuji, S	2
Nagami, Y	2
Hikichi, T	2
Kobayashi, M	2
Morita, Y	2
Sumiyoshi, T	2
Iguchi, M	2
Tomida, H	2
Inoue, T	2
Mikami, T	2
Hasatani, K	2
Nishikawa, J	2
Matsumura, T	3
Nebiki, H	2
Nakamatsu, D	2
Ohnita, K	2
Suzuki, H	2
Ueyama, H	2
Hayashi, Y	2
Sugimoto, M	2
Yamaguchi, S	2
Michida, T	2
Yada, T	2
Asahina, Y	2
Narasaka, T	2
Kuribayashi, S	2
Kiyotoki, S	2
Mabe, K	2
Masamune, A	2
Fujishiro, M	4
Manunga, J	1
Pedersen, C	1
Stanberry, L	1
Pai, A	1
Skeik, N	1
Sullivan, TM	2
Kaya, K	1
Mungan, U	1
Björn, R	1
Lehto, J	1
Malmberg, M	1
Anttila, V	1
Airaksinen, KEJ	1
Gunn, J	1
Kiviniemi, T	1
Enciu, A	1
Loeschner, D	1
Alhallak, M	1
Kellner, G	1
Meyer, A	2
Lauten, A	1
Steinbrecher, A	1
Gerlach, R	1
Hosoi, M	1
Ohbayashi, M	1
Miyahara, Y	1
Fujii, T	1
Kise, H	1
Kogo, M	1
Simon, SJ	1
Patell, R	1
Zwicker, JI	1
Kazi, DS	1
Hollenbeck, BL	1
Yan, Z	1
Liu, Y	1
Ruze, R	1
Xiong, Y	1
Han, H	1
Zhan, H	1
Wang, M	1
Zhang, G	1
Abraham, NS	1
Won, D	1
Kim, JS	1
Ji, JS	1
Kim, BW	1
Choi, H	1
Krill, TS	1
Chatila, A	1
Marcondes, F	1
Samuel, R	1
Guturu, P	1
Parupudi, S	1
Kaltenborn, A	1
Frey-Wille, S	1
Hoffmann, S	1
Wille, J	1
Schulze, C	1
Settje, A	1
Vogt, PM	1
Gutcke, A	1
Ruettermann, M	1
Martí, D	1
Carballeira, D	1
Morales, MJ	1
Concepción, R	1
Del Castillo, H	1
Marschall, A	1
Delgado-Calva, FA	1
Dejuán-Bitriá, C	1
Pérez-Guzmán, J	1
López-Soberón, E	1
Palazuelos, J	1
Álvarez-Antón, S	1
Gajanana, D	1
Rogers, T	1
Weintraub, WS	1
Kolm, P	1
Iantorno, M	1
Khalid, N	1
Shlofmitz, E	1
Khan, JM	1
Musallam, A	1
Ben-Dor, I	1
Satler, LF	1
Zhang, C	2
Torguson, R	1
Waksman, R	1
Takahashi, R	1
Fujikawa, T	3
Bianco, M	1
Careggio, A	1
Destefanis, P	1
Luciano, A	1
Perrelli, MG	1
Quadri, G	1
Rossini, R	2
Campo, G	1
Vizzari, G	1
D'Ascenzo, F	1
Anselmino, M	1
Biondi-Zoccai, G	1
Ibáñez, B	1
Montagna, L	1
Varbella, F	1
Cerrato, E	1
Schlachtenberger, G	1
Deppe, AC	1
Gerfer, S	1
Choi, YH	1
Zeriouh, M	1
Liakopoulos, O	1
Wahlers, TCW	1
Hamada, K	1
Kanzaki, H	1
Inoue, M	1
Ishiyama, S	1
Yamauchi, K	1
Miyahara, K	1
Toyokawa, T	1
Tsuzuki, T	1
Miyaike, J	1
Matsubara, M	1
Takahashi, S	1
Nishimura, M	1
Takenaka, R	1
Yunoki, N	1
Hori, S	1
Kobayashi, S	1
Yamasaki, Y	1
Kawahara, Y	1
Ishikawa, H	1
Okada, H	1
Zhang, ZZ	1
Zhang, SZ	1
Zhou, HM	1
Fan, YQ	1
Liu, MH	1
Zhong, XB	1
Yang, DY	1
Guo, Y	1
Zhuang, XD	1
Liao, XX	1
Ashkenazi, I	1
Schermann, H	1
Gold, A	1
Gurel, R	1
Chechik, O	3
Warschawski, Y	1
Schwarzkopf, R	1
Snir, N	1
Rodino, AM	1
Henderson, JB	1
Dobbins, KF	1
Rubin, DT	1
Hollis, IB	1
Kubota, M	1
Matsuoka, T	1
Yamasaki, T	1
Kokubun, H	1
Hagimoto, H	1
Murata, S	1
Makita, N	1
Suzuki, I	1
Abe, Y	1
Tohi, Y	1
Tsutsumi, N	1
Inoue, K	1
Kawakita, M	1
Nakashima, CAK	1
Dallan, LAO	1
Lisboa, LAF	1
Jatene, FB	1
Hajjar, LA	1
Soeiro, AM	1
Furtado, RHM	1
Dalçoquio, TF	1
Baracioli, LM	1
Lima, FG	1
Giraldez, RRCV	1
Silva, BA	1
Costa, MSS	1
Strunz, CMC	1
Dallan, LRP	1
Barbosa, CJDG	1
Britto, FAB	1
Farkouh, ME	1
Gurbel, PA	4
Nicolau, JC	1
Shiroma, S	1
Vogel, B	1
Baber, U	1
Cohen, DJ	1
Sartori, S	1
Sharma, SK	1
Angiolillo, DJ	1
Farhan, S	1
Goel, R	1
Zhang, Z	1
Briguori, C	1
Collier, T	1
Dangas, G	1
Dudek, D	1
Escaned, J	1
Gil, R	1
Han, YL	1
Kaul, U	1
Kornowski, R	1
Krucoff, MW	1
Kunadian, V	1
Mehta, SR	2
Moliterno, D	1
Sardella, G	1
Witzenbichler, B	1
Pocock, S	1
Huber, K	1
Mehran, R	2
Diab, S	1
Arazi, M	1
Sternik, L	1
Raanani, E	2
Kachel, E	1
Grosman-Rimon, L	1
Shalabi, A	1
Amir, O	1
Carasso, S	1
Watts, PJ	2
Kopstein, M	2
Harkness, W	2
Cornett, B	2
Dziadkowiec, O	2
Hicks, ME	2
Hassan, S	2
Scherbak, D	2
Jenkins, P	1
Rashidi, A	1
Leins, F	1
Sandalcioglu, IE	1
Luchtmann, M	1
Seoudy, H	1
Thomann, M	1
Frank, J	1
Lutz, M	1
Puehler, T	1
Lutter, G	1
Müller, OJ	1
Frey, N	1
Saad, M	2
Frank, D	1
Björklund, E	1
Malm, CJ	1
Nielsen, SJ	1
Hansson, EC	1
Tygesen, H	1
Romlin, BS	1
Martinsson, A	1
Omerovic, E	1
Pivodic, A	1
Jeppsson, A	1
Tatami, Y	1
Ishii, H	1
Aoki, T	1
Harada, K	1
Hirayama, K	1
Shibata, Y	1
Sumi, T	1
Negishi, Y	1
Kawashima, K	1
Kunimura, A	1
Kawamiya, T	1
Yamamoto, D	1
Suzuki, S	1
Murohara, T	1
Oimatsu, Y	1
Kaikita, K	1
Ishii, M	1
Mitsuse, T	1
Ito, M	1
Arima, Y	1
Sueta, D	2
Takahashi, A	1
Iwashita, S	1
Yamamoto, E	1
Kojima, S	1
Hokimoto, S	2
Tsujita, K	1
Monden, K	1
Sadamori, H	1
Hioki, M	1
Ohno, S	1
Saneto, H	1
Ueki, T	1
Yabushita, K	1
Ono, K	1
Sakaguchi, K	1
Takakura, N	1
Yhim, HY	1
Lee, J	1
Lee, JY	3
Lee, JO	1
Bang, SM	1
Bala, A	1
Huddleston, JI	1
Goodman, SB	1
Maloney, WJ	1
Amanatullah, DF	1
Ueki, N	1
Futagami, S	1
Akimoto, T	1
Maruki, Y	1
Yamawaki, H	1
Kodaka, Y	1
Nagoya, H	1
Shindo, T	1
Kusunoki, M	1
Kawagoe, T	1
Gudis, K	1
Miyake, K	1
Iwakiri, K	1
Dong, J	1
Wei, K	1
Deng, J	1
Zhou, X	1
Huang, X	1
Deng, M	1
Lü, M	1
Wu, W	1
Chen, J	2
Ding, Q	1
Yang, D	1
Yu, H	1
Lin, J	1
Goes, R	1
Muskens, IS	1
Smith, TR	1
Mekary, RA	1
Broekman, MLD	1
Moojen, WA	1
Goldhammer, JE	1
Herman, CR	1
Berguson, MW	1
Torjman, MC	1
Epstein, RH	1
Sun, JZ	1
Garfinkel, JH	1
Gladnick, BP	1
Roland, N	1
Romness, DW	1
Sá, MPBO	1
Soares, AF	1
Miranda, RGA	1
Araújo, ML	1
Menezes, AM	1
Silva, FPV	1
Lima, RC	1
Giustino, G	2
Dangas, GD	1
Kirtane, AJ	1
Redfors, B	1
Généreux, P	1
Brener, SJ	1
Prats, J	1
Pocock, SJ	1
Stone, GW	1
Wang, G	1
Liu, X	1
Li, Y	2
Sun, J	1
Sharifi, M	1
Kamali, A	1
Ghandi, Y	1
Aboul-Hassan, SS	1
Stankowski, T	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effects of Antiplatelets Discontinuation in Patients Receiving Polypectomy: Randomized Controlled Trial[NCT02865824]		180 participants (Anticipated)	Interventional	2016-01-31	Enrolling by invitation
The Importance of Evaluation of Platelet Aggregability in the Release of Coronary Artery Bypass Grafting in Patients With Acute Coronary Syndrome With Dual Antiplatelet Therapy.[NCT02516267]		190 participants (Actual)	Interventional	2015-07-31	Completed
Ticagrelor With Aspirin or Alone in High-Risk Patients After Coronary Intervention[NCT02270242]	Phase 4	9,006 participants (Actual)	Interventional	2015-07-31	Completed
Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS)[NCT00198068]		700 participants (Anticipated)	Observational	2003-09-30	Recruiting
A Large, International, Placebo-controlled, Factorial Trial to Assess the Impact of Clonidine and Acetyl-salicylic Acid (ASA) in Patients Undergoing Noncardiac Surgery Who Are at Risk of a Perioperative Cardiovascular Event[NCT01082874]	Phase 3	10,010 participants (Actual)	Interventional	2010-07-31	Completed
A Randomized, Parallel Group, Double-Blind Study of Ticagrelor Compared With Aspirin for Prevention of Vascular Events in Patients Undergoing Coronary Artery Bypass Graft Operation TiCAB- Ticagrelor in CABG[NCT01755520]	Phase 3	1,893 participants (Actual)	Interventional	2013-04-24	Terminated (stopped due to DSMB Interim Analyses)
Bivalirudin vs Heparin in NSTEMI and STEMI in Patients on Modern Antiplatelet Therapy in SWEDEHEART A Multicenter, Prospective, Randomized Controlled Clinical Trial Based on the SWEDEHEART Platform[NCT02311231]	Phase 4	6,012 participants (Actual)	Interventional	2014-06-30	Completed
A Prospective, Nonrandomized, Study Comparing the Use of Aspirin and Intraoperative Blood Loss and Postoperative Complications Following Open Inguinal Hernia Repair.[NCT02084615]		300 participants (Anticipated)	Interventional	2014-08-31	Enrolling by invitation
MET: REevaluation for Perioperative cArdIac Risk (MET-REPAIR): a Prospective, Multi-centre Cohort Observational Study- Presepsin (sCD14-ST) for Perioperative Risk Prediction Nested Cohort Study[NCT03489486]		1,695 participants (Anticipated)	Observational	2018-06-15	Recruiting
MET: REevaluation for Perioperative cArdIac Risk (MET-REPAIR) Observational Multicentre Study[NCT03016936]		15,000 participants (Actual)	Observational	2017-08-01	Completed
Association Between Perioperative Bleeding and Aspirin Use in Spine Surgery: A Randomized, Controlled Trial[NCT02807441]	Phase 3	0 participants (Actual)	Interventional	2016-07-31	Withdrawn
Efficacy of Local Hemostatic Management in Implant Surgery in Anticoagulated Patients on Warfarin: a Randomized Clinical Study[NCT04846114]		71 participants (Actual)	Interventional	2016-03-31	Completed
PercutaNEOus Coronary Intervention Followed by Monotherapy INstead of Dual Antiplatelet Therapy in the SETting of Acute Coronary Syndromes: The NEO-MINDSET Trial A Drug Reduction Study for Patients With Acute Coronary Syndrome in the Unified Health System[NCT04360720]	Phase 3	3,400 participants (Anticipated)	Interventional	2020-10-15	Recruiting
The Effect of Remote Ischemic Preconditioning on Myocardial Injury After Noncardiac Surgery in Patients at a High Risk of Cardiac Events[NCT05733208]		766 participants (Anticipated)	Interventional	2023-05-06	Recruiting
Does Platelet Inhibition Predict Surgery Related Bleeding in Patients Undergoing Emergent Cardiac Surgery During Dual Antiplatelet Therapy - a Pilot Study[NCT01468597]		167 participants (Actual)	Observational	2011-01-31	Completed
Maintenance of an Antiaggregation by Acetylsalicylic Acid, Less or Equal to 250mg While a Extracorporeal Lithotripsy (ECL) Session on a Kidney Stone is Perfomed: Comparative Unicentric Prospective Study[NCT03437057]		300 participants (Anticipated)	Interventional	2018-01-08	Recruiting
MONET BRIDGE(Maintenance Of aNtiplatElet Therapy in Patients With Coronary Stenting Undergoing Surgery) - (Mantenimento Della Terapia Antiaggregante Nei Pazienti Portatori di Stent Coronarico Candidati a Chirurgia)[NCT03862651]	Phase 2	140 participants (Anticipated)	Interventional	2019-06-01	Not yet recruiting
Multicenter, Prospective Cohort of Patient With Coronary Stents Undergoing Non Cardiac Surgery or Invasive Procedures.[NCT01045850]		1,312 participants (Actual)	Observational	2006-02-28	Completed
Strategy for Managing Antiplatelet Therapy in the Perioperative Period of Non Coronary Surgery[NCT00190307]	Phase 4	293 participants (Actual)	Interventional	2005-06-30	Completed
Prospective Study of the Assessment of the Dental Protocol for Tooth Extraction in Patients With Atrial Fibrillation in Continuous Use of New Oral Anticoagulants: A Pilot Study[NCT03181386]	Phase 3	60 participants (Actual)	Interventional	2017-05-03	Completed
Management of Antiplatelet Regimen During Surgical Procedures (MARS Registry)[NCT03981835]		1,492 participants (Anticipated)	Observational [Patient Registry]	2019-08-01	Recruiting
DEPOSITION: Pilot Study Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery[NCT03376061]	Phase 4	97 participants (Actual)	Interventional	2017-12-21	Completed
Single Centre Randomised Controlled Trial to Assess the Effect of the Addition of Twenty-four Hours of Oral Tranexamic Acid Post-operatively to a Single Intra-operative Intravenous Dose of Tranexamic Acid on Calculated Blood Loss Following Primary Hip and[NCT03690037]	Phase 4	1,089 participants (Actual)	Interventional	2016-07-07	Completed
To Investigate Post-procedure Hemorrhage and Cardiovascular Events in Taiwanese Patients Who Continue or Discontinue Low-Dose Aspirin Before Transrectal Prostate Biopsy: a Prospective Randomized Trial[NCT02744937]	Phase 4	150 participants (Anticipated)	Interventional	2016-04-30	Not yet recruiting
Maintenance Of aNtiplatElet Therapy in Patients With Coronary Stenting Undergoing Surgery[NCT03445273]		1,800 participants (Anticipated)	Observational [Patient Registry]	2018-11-21	Not yet recruiting
Effect of Low Molecular Weight Heparin vs Unfractionated Heparin on Bleeding After Cardiac Surgery[NCT00420667]		43 participants (Actual)	Interventional	2004-11-30	Completed
A Double Blind Randomized Control Trial of Post-Operative Low Molecular Weight Heparin Bridging Therapy Versus Placebo Bridging Therapy for Patients Who Are at High Risk for Arterial Thromboembolism (PERIOP 2)[NCT00432796]	Phase 3	1,473 participants (Actual)	Interventional	2006-12-31	Active, not recruiting
Phase I/IIa Gene Transfer Clinical Trial for Duchenne Muscular Dystrophy Using rAAVrh74.MCK.GALGT2[NCT03333590]	Phase 1/Phase 2	2 participants (Actual)	Interventional	2017-11-06	Active, not recruiting
China Research for Severe Spontaneous Intracerebral Hemorrhage（CRISIH）[NCT05975398]		450 participants (Anticipated)	Observational [Patient Registry]	2022-07-01	Recruiting
Effect and Safety of Surgical Intervention for Severe Spontaneous Intracerebral Hemorrhage Patients on Long-term Oral Antiplatelet Treatment[NCT05766865]		450 participants (Actual)	Observational	2019-07-10	Completed
Must Aspirin be Discontinued Prior to TURBT: a Prospective, Randomized, Non-inferiority Trial Comparing Peri-operative Aspirin Continuation Versus Discontinuation.[NCT02350543]	Phase 4	50 participants (Actual)	Interventional	2015-02-28	Terminated (stopped due to Insufficient recruitment.)
PHASE IV Study of Dual Antiplatelet Therapy Versus Oral Anticoagulation for a Short Time to Prevent Cerebral Embolism After Percutaneous Aortic Valve Implantation. Multicenter Randomized Clinical Trial[NCT01642134]	Phase 4	124 participants (Actual)	Interventional	2013-04-30	Completed
Observatory of Anticoagulation After Bioprosthetic Aortic Valve Replacement[NCT01293188]		434 participants (Actual)	Observational	2011-01-31	Completed
Influence of Tourniquet Use and Surgery Duration on the Incidence of Deep Vein Thrombosis in Total Knee Arthroplasty[NCT01559532]		78 participants (Actual)	Observational	2008-02-29	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Number of participants with first occurrence of clinically relevant bleeding episode, defined as Bleeding Academic Research Consortium (BARC) Types 2, 3 or 5 bleeding. BARC bleeding types range from 0 (no bleeding) to 5 (fatal bleeding). (NCT02270242)
Timeframe: 12 months after randomization

Number of Participants With Ischemic Episode

Intervention	Participants (Count of Participants)
Placebo + Ticagrelor	141
Aspirin + Ticagrelor	250

Number of participants with first occurrence of confirmed all-cause death, non-fatal myocardial infarction or stroke. (NCT02270242)
Timeframe: 12 months after randomization

Composite of All-cause Mortality and Nonfatal MI

BARC Bleeding

Intervention	Participants (Count of Participants)
Placebo + Ticagrelor	135
Aspirin + Ticagrelor	137

Intervention	participants (Number)
Active Clonidine and Active ASA	173
Active Clonidine and Placebo ASA	194
Placebo Clonidine and Active ASA	178
Placebo Clonidine and Placebo ASA	161

Intracranial bleed within 48 hours, Reoperation after closure of sternotomy for the purpose of controlling bleeding, Transfusion of equal to or more than 5 Units of packed red blood cells within a 48-hour period, Chest tube output of equal to or more than 2 L within a 24-h period. (NCT01468597)
Timeframe: until postoperative day 2

Calculated Blood Loss

Mean Concentration of TxA in Plasma Collected From Participants

Intervention	participants (Number)
One Group	72

Intervention	milliters (Median)
One Group	1996

Plasma TxA concentrations measured from blood samples taken upon arrival in the ICU (NCT03376061)
Timeframe: on arrival in ICU within 3 hours

Median Number of Hours Participants Spent in ICU

Intervention	microgram per milliliter per kilogram (Mean)
Topical TxA (Intervention)	0.58
Intravenous TxA (Control)	1.10

Number of hours participants spent in the intensive care unit (ICU) (NCT03376061)
Timeframe: Number of hours spent in ICU from arrival to exit (collected at the Post-Operative Visit).

Median Volume of Mediastinal Fluid Collected From Participants

Intervention	hours (Median)
Topical TxA (Intervention)	23
Intravenous TxA (Control)	26

Cumulative volume (mL) of fluid collected from mediastinal drainage tubes 24 hours after the surgical procedure (NCT03376061)
Timeframe: Fluid collected in the first 24 hours after the surgical procedure

Number of Participants With Mortality

Intervention	mL (Median)
Topical TxA (Intervention)	500
Intravenous TxA (Control)	540

The occurrence of death due to any cause (NCT03376061)
Timeframe: Patients will be followed post-operatively until hospital discharge

Number of Participants With RBC Transfusion

Intervention	Participants (Count of Participants)
Topical TxA (Intervention)	1
Intravenous TxA (Control)	1

Patients requiring a red blood cell transfusion (NCT03376061)
Timeframe: Intra-operative and post-operative RBC transfusions

Number of Participants With Re-operation for Bleeding or Tamponade

Intervention	Participants (Count of Participants)
Topical TxA (Intervention)	19
Intravenous TxA (Control)	23

Occurrence of re-operation for the purpose of bleeding or cardiac tamponade (NCT03376061)
Timeframe: Patients will be followed post-operatively until hospital discharge

Number of Participants With Seizures

Intervention	Participants (Count of Participants)
Topical TxA (Intervention)	0
Intravenous TxA (Control)	1

Patients experiencing a post-operative seizure (NCT03376061)
Timeframe: Patients will be followed post-operatively until hospital discharge

Expression of GALGT2 as Demonstrated by Immunofluorescent Staining With Anti-CT Epitope Antibodies or WFA Lectin in Muscle Biopsy Sections at 120 Days Post Injection (Cohort 1) and 90 Days Post-injection (Cohort 2).

Intervention	Participants (Count of Participants)
Topical TxA (Intervention)	0
Intravenous TxA (Control)	1

Percentage of fibers expressing GALGT2 in each biopsy sample. (NCT03333590)
Timeframe: Day 90 (Cohort 2) and Day 120 (Cohort 1)

GALGT2 Protein Expression Quantified by Western Blot and Assessed by Densitometry in Muscle Biopsy Tissue at 120 Days Post-injection (Cohort 1) and 90 Days Post-injection (Cohort 2)

Number of Unanticipated Grade III or Higher Treatment-Related Toxicities

Number of Meters Walked During the 6 Minute Walk Test

Intervention	Percentage of Positive Fibers (Number)
Cohort 1 (Minimal Efficacious Dose)	1.95
Cohort 2	1.72

Intervention	ng/mg total protein (Number)
Cohort 1 (Minimal Efficacious Dose)	12
Cohort 2	14.6

Intervention	events (Number)
Cohort 1 (Minimal Efficacious Dose)	0
Cohort 2	0

(NCT03333590)
Timeframe: Day 90 (Cohort 2) and Day 120 (Cohort 1) and Day 180 for both cohorts

Score of Muscle Function Using the The North Star Ambulatory Assessment (NSAA).

Intervention	meters (Number)
	Day 90 (Cohort 2) /Day 120 (Cohort 1)	Day 180
Cohort 1 (Minimal Efficacious Dose)	320	324
Cohort 2 (Minimal Efficacious Dose)	405	416

The NSAA provides a score between 0 and 34 where higher numbers represent greater muscle function. (NCT03333590)
Timeframe: Days 90 (Cohort 2), 120 (Cohort 1) and both Cohorts at Day 180, Months 12, 18 and 24

Strength of the Bilateral Knee Flexors and Extensors During the Maximal Voluntary Isometric Strength Test.

Intervention	score on a scale (Number)
	Day 90/Day 120	Day 180	Month 12	Month 18	Month 24
Cohort 1 (Minimal Efficacious Dose)	16	14	10	6	2
Cohort 2	21	23	23	23	23

(NCT03333590)
Timeframe: Days 90 (Cohort 2), 120 (Cohort 1) and both Cohorts at Day 180, Months 12, 18 and 24

Time Taken to Walk 100 Meters During the 100 Meter Walk Test.

Intervention	kg (Number)
	Day 90/Day 120-Right Knee Extension	Day 90/Day 120-Right Knee Flexion	Day 90/Day 120- Left Knee Extension	Day 90/Day 120-Left Knee Flexion	Day 180-Right Knee Extension	Day 180-Right Knee Flexion	Day 180-Left Knee Extension	Day 180-Left Knee Flexion	Month 12-Right Knee Extension	Month 12-Right Knee Flexion	Month 12-Left Knee Extension	Month 12-Left Knee Flexion	Month 18-Right Knee Extension	Month 18-Right Knee Flexion	Month 18-Left Knee Extension	Month 18-Left Knee Flexion	Month 24-Right Knee Extension	Month 24-Right Knee Flexion	Month 24-Left Knee Extension	Month 24-Left Knee Flexion
Cohort 1 (Minimal Efficacious Dose)	7.42	6.06	8.78	6.12	7.13	6.1	8.66	6.69	7.49	5.67	7.5	5.32	4.55	6.11	4.96	6.26	5.06	4.41	6.93	4.17
Cohort 2	7.04	8.12	5.9	8.4	9.73	4.24	8.19	5.25	9.85	5.85	8.02	5.12	7.67	6.89	7.34	6.08	9.81	5.04	5.21	4.87

(NCT03333590)
Timeframe: Days 90 (Cohort 2), 120 (Cohort 1); both Cohorts at Day 180, Months 12, 18 and Cohort 2 at Month 24

Time Taken to Walk 100 Meters During the 100 Meter Walk Test.

Intervention	seconds (Number)
	Day 90/Day 120	Day 180	Month 12	Month 18
Cohort 1 (Minimal Efficacious Dose)	98.2	110.9	144.5	167.8

(NCT03333590)
Timeframe: Days 90 (Cohort 2), 120 (Cohort 1); both Cohorts at Day 180, Months 12, 18 and Cohort 2 at Month 24

Article	Year
Risk of colonoscopic post-polypectomy bleeding in patients on single antiplatelet therapy: systematic review with meta-analysis. Surgical endoscopy, 2022, Volume: 36, Issue:4 Topics: Aspirin; Colonic Polyps; Colonoscopy; Hemorrhage; Humans; Intestinal Polyps; Platelet Aggregation In	2022
The risk of aspirin induced postoperative hemorrhage: a systematic review and meta-analysis. Expert review of gastroenterology & hepatology, 2022, Volume: 16, Issue:10 Topics: Aspirin; Endoscopic Mucosal Resection; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Platelet	2022
Antiplatelets, anticoagulants, and colonoscopic polypectomy. Gastrointestinal endoscopy, 2020, Volume: 91, Issue:2 Topics: Anticoagulants; Aspirin; Colonic Polyps; Colonoscopy; Deprescriptions; Embolism; Factor Xa Inhibitor	2020
P2Y12 inhibitors monotherapy after short course of dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a meta-analysis of randomized clinical trials including 29 089 patients. European heart journal. Cardiovascular pharmacotherapy, 2021, 05-23, Volume: 7, Issue:3 Topics: Aspirin; Dual Anti-Platelet Therapy; Humans; Percutaneous Coronary Intervention; Platelet Aggregatio	2021
A systematic review of guidelines for dual antiplatelet therapy in coronary artery bypass graft. European journal of clinical investigation, 2021, Volume: 51, Issue:1 Topics: Aspirin; Coronary Artery Bypass; Coronary Artery Disease; Deprescriptions; Dual Anti-Platelet Therap	2021
Effects of antithrombotic therapy on bleeding after endoscopic submucosal dissection. Gastrointestinal endoscopy, 2017, Volume: 86, Issue:5 Topics: Anticoagulants; Aspirin; Deprescriptions; Endoscopic Mucosal Resection; Endoscopy, Gastrointestinal;	2017
Continued use of low-dose aspirin may increase risk of bleeding after gastrointestinal endoscopic submucosal dissection: A meta-analysis. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2017, Volume: 28, Issue:5 Topics: Anticoagulants; Aspirin; Endoscopic Mucosal Resection; Gastrointestinal Neoplasms; Humans; Platelet	2017
Risk of aspirin continuation in spinal surgery: a systematic review and meta-analysis. The spine journal : official journal of the North American Spine Society, 2017, Volume: 17, Issue:12 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Neurosurgical Procedures; Postoperative He	2017
Stopping versus continuing acetylsalicylic acid before coronary artery bypass surgery: A systematic review and meta-analysis of 14 randomized controlled trials with 4499 patients. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2017, Nov-01, Volume: 52, Issue:5 Topics: Aspirin; Coronary Artery Bypass; Humans; Myocardial Infarction; Postoperative Hemorrhage; Randomized	2017
Safety of continuing aspirin therapy during spinal surgery: A systematic review and meta-analysis. Medicine, 2017, Volume: 96, Issue:46 Topics: Aspirin; Blood Loss, Surgical; Blood Transfusion; Humans; Platelet Aggregation Inhibitors; Postopera	2017
The use of preoperative aspirin in cardiac surgery: A systematic review and meta-analysis. Journal of cardiac surgery, 2017, Volume: 32, Issue:12 Topics: Aspirin; Cardiac Surgical Procedures; Erythrocyte Transfusion; Humans; Models, Statistical; Odds Rat	2017
Risk of complications with use of aspirin during renal biopsy: A systematic review. Clinical nephrology, 2018, Volume: 89, Issue:2 Topics: Aspirin; Biopsy; Humans; Kidney; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk	2018
Optimal duration of dual antiplatelet therapy after PCI: integrating procedural complexity, bleeding risk and the acuteness of clinical presentation. Expert review of cardiovascular therapy, 2018, Volume: 16, Issue:10 Topics: Aspirin; Coronary Artery Disease; Drug Administration Schedule; Drug Therapy, Combination; Drug-Elut	2018
Dual anti-platelet therapy after coronary artery bypass grafting: is there any benefit? A systematic review and meta-analysis. Journal of cardiac surgery, 2013, Volume: 28, Issue:2 Topics: Angina Pectoris; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Graft Occl	2013
Open and robot-assisted radical retropubic prostatectomy in men receiving ongoing low-dose aspirin medication: revisiting an old paradigm? BJU international, 2014, Volume: 114, Issue:3 Topics: Aged; Anticoagulants; Aspirin; Blood Transfusion; Coronary Disease; Heparin, Low-Molecular-Weight; H	2014
Safety and efficacy outcomes of preoperative aspirin in patients undergoing coronary artery bypass grafting: a systematic review and meta-analysis. Journal of cardiovascular pharmacology and therapeutics, 2014, Volume: 19, Issue:1 Topics: Aspirin; Coronary Artery Bypass; Dose-Response Relationship, Drug; Humans; Platelet Aggregation Inhi	2014
Who might benefit from early aspirin after coronary artery surgery? Interactive cardiovascular and thoracic surgery, 2014, Volume: 19, Issue:3 Topics: Aged; Aspirin; Benchmarking; Coronary Artery Bypass; Coronary Artery Disease; Coronary Thrombosis; D	2014
Aspirin, clopidogrel, and the surgeon. Advances in surgery, 2014, Volume: 48 Topics: Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Humans; Platelet Aggregati	2014
Perioperative aspirin management after POISE-2: some answers, but questions remain. Anesthesia and analgesia, 2015, Volume: 120, Issue:3 Topics: Aspirin; Cardiovascular Diseases; Drug Administration Schedule; Fibrinolytic Agents; Humans; Periope	2015
Aspirin and coronary artery surgery: a systematic review and meta-analysis. British journal of anaesthesia, 2015, Volume: 115, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Loss, Surgical; Blood Transfusion; Cardiac S	2015
Perioperative Management to Reduce Cardiovascular Events. Circulation, 2016, Mar-15, Volume: 133, Issue:11 Topics: Adrenergic beta-Antagonists; Aged; Anesthesia; Anticoagulants; Arthroplasty, Replacement, Knee; Aspi	2016
Bleeding after endoscopic submucosal dissection: Risk factors and preventive methods. World journal of gastroenterology, 2016, Jul-14, Volume: 22, Issue:26 Topics: Anticoagulants; Aspirin; Comorbidity; Endoscopic Mucosal Resection; Endoscopy, Gastrointestinal; Gas	2016
Adverse clinical outcomes associated with a low dose and a high dose of aspirin following percutaneous coronary intervention: a systematic review and meta-analysis. BMC cardiovascular disorders, 2016, 09-02, Volume: 16, Issue:1 Topics: Aspirin; Coronary Artery Disease; Global Health; Humans; Incidence; Percutaneous Coronary Interventi	2016
Aspirin Use Prior to Coronary Artery Bypass Grafting Surgery: a Systematic Review. Current cardiology reports, 2017, Volume: 19, Issue:2 Topics: Aspirin; Coronary Artery Bypass; Coronary Artery Disease; Humans; Meta-Analysis as Topic; Myocardial	2017
Oral antiplatelet agents and bleeding risk in relation to major cardiovascular surgery. Current drug safety, 2006, Volume: 1, Issue:3 Topics: Aspirin; Cardiovascular Surgical Procedures; Cilostazol; Clopidogrel; Dipyridamole; Humans; Platelet	2006
Treatment strategies in non-ST-elevation acute coronary syndromes in patients undergoing percutaneous coronary intervention: an evidence-based review of clinical trial results and treatment guidelines: report on a roundtable discussion. Journal of interventional cardiology, 2008, Volume: 21, Issue:4 Topics: Acute Coronary Syndrome; Algorithms; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Cardio	2008
Biological and pharmacological aspects of perioperative hemorrhagic complications associated with oral platelet-directed antithrombotic agents. Focus on isolated coronary artery bypass grafting and oral irreversible P2Y(12) receptor antagonists. Thrombosis research, 2009, Volume: 123, Issue:3 Topics: Administration, Oral; Aspirin; Coronary Artery Bypass; Hemostasis; Hemostasis, Surgical; Humans; Pla	2009
[Should platelet inhibitors be discontinued before gastrointestinal endoscopy?]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2008, Nov-06, Volume: 128, Issue:21 Topics: Aspirin; Endoscopy, Gastrointestinal; Evidence-Based Medicine; Humans; Platelet Aggregation Inhibito	2008
[Bleeding and thromboembolic risk. Perioperative strategy in aspirin/clopidogrel]. Pharmazie in unserer Zeit, 2009, Volume: 38, Issue:4 Topics: Aspirin; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk A	2009
Antiplatelet therapy discontinuation following drug-eluting stent placement: dangers, reasons, and management recommendations. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2009, Dec-01, Volume: 74, Issue:7 Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Co	2009
Clopidogrel: mechanisms of action and review of the evidence relating to use during skin surgery procedures. Clinical and experimental dermatology, 2010, Volume: 35, Issue:4 Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Dermatologic Surgical Procedures; Drug Therapy, Combinat	2010
Comparing consensus guidelines on thromboprophylaxis in orthopedic surgery. Journal of thrombosis and haemostasis : JTH, 2010, Volume: 8, Issue:4 Topics: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Aspirin; Blood Loss, Surgical; Cast	2010
[Discontinuation of treatment with platelet aggregation inhibitors in surgical patients with cardiac stents]. Ugeskrift for laeger, 2010, Mar-15, Volume: 172, Issue:11 Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Thrombosis; Dru	2010
[Current coagulation diagnostics in intensive care medicine]. Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2011, Volume: 106, Issue:3 Topics: Anticoagulants; Aspirin; Blood Coagulation Tests; Clopidogrel; Cost-Benefit Analysis; Early Diagnosi	2011
Pancreas graft thrombosis: causes, prevention, diagnosis, and intervention. Current opinion in organ transplantation, 2012, Volume: 17, Issue:1 Topics: Acute Disease; Anticoagulants; Aspirin; Fibrinolytic Agents; Graft Rejection; Heparin; Humans; Incid	2012
[Acetylsalicylic acid in patients with planned (elective) interventions on the coronary arteries. Risks and benefits]. Kardiologiia, 2012, Volume: 52, Issue:4 Topics: Aspirin; Blood Loss, Surgical; Blood Transfusion; Coronary Artery Bypass; Coronary Artery Disease; H	2012
Oral surgery in patients on anticoagulant therapy. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2002, Volume: 94, Issue:1 Topics: Analgesics; Anti-Infective Agents; Anticoagulants; Aspirin; Dental Care for Chronically Ill; Drug In	2002
Antiplatelet drugs : is there a surgical risk? Journal (Canadian Dental Association), 2002, Volume: 68, Issue:11 Topics: Aspirin; Blood Coagulation Disorders; Blood Loss, Surgical; Cyclooxygenase Inhibitors; Decision Tree	2002
Postoperative hemorrhage with nonsteroidal anti-inflammatory drug use after tonsillectomy: a meta-analysis. Archives of otolaryngology--head & neck surgery, 2003, Volume: 129, Issue:10 Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Child, Preschool; Diclof	2003
Reexploration for bleeding after coronary artery bypass surgery: risk factors, outcomes, and the effect of time delay. The Annals of thoracic surgery, 2004, Volume: 78, Issue:2 Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Body Mass Index; Cardiotonic Agents; Coronary Arte	2004
Late bleeding from right internal mammary artery after HeartMate left ventricular assist device implantation. The Annals of thoracic surgery, 2004, Volume: 78, Issue:2 Topics: Adult; Anticoagulants; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Cardiomyopathy, Dila	2004
Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: a systematic review and meta-analysis of randomized clinical trials. The Journal of thoracic and cardiovascular surgery, 2004, Volume: 128, Issue:3 Topics: Aprotinin; Aspirin; Blood Transfusion; Coronary Artery Bypass; Hemostatics; Humans; Platelet Aggrega	2004
Balancing the benefit and risk of oral antiplatelet agents in coronary artery bypass surgery. The Annals of thoracic surgery, 2005, Volume: 80, Issue:2 Topics: Administration, Oral; Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Coron	2005
Drug insight: antithrombotic therapy after percutaneous coronary intervention in patients with an indication for anticoagulation. Nature clinical practice. Cardiovascular medicine, 2006, Volume: 3, Issue:12 Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Admi	2006
Aspirin and bleeding in dentistry: an update and recommendations. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2007, Volume: 104, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cardiovascular Diseases; Dental C	2007
Low-dose aspirin and clopidogrel: how to act in patients scheduled for day surgery. Current opinion in anaesthesiology, 2007, Volume: 20, Issue:6 Topics: Anesthesia; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage;	2007
The effect of herbal medicines on platelet function: an in vivo experiment and review of the literature. Plastic and reconstructive surgery, 2007, Volume: 120, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Coagulation; Blood Coagulation Tests; Blood Platelets	2007
A meta-analysis of complications attributed to anticoagulation among patients following cutaneous surgery. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2008, Volume: 34, Issue:2 Topics: Anticoagulants; Aspirin; Fibrinolytic Agents; Humans; Postoperative Hemorrhage; Skin Diseases; Throm	2008
The effect of pre-operative aspirin on bleeding, transfusion, myocardial infarction, and mortality in coronary artery bypass surgery: a systematic review of randomized and observational studies. European heart journal, 2008, Volume: 29, Issue:8 Topics: Aged; Aspirin; Blood Loss, Surgical; Coronary Artery Bypass; Coronary Thrombosis; Female; Humans; Ma	2008
Guideline on antiplatelet and anticoagulation management in cardiac surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, Volume: 34, Issue:1 Topics: Anticoagulants; Aprotinin; Aspirin; Cardiac Surgical Procedures; Clopidogrel; Contraindications; Evi	2008
Guideline on antiplatelet and anticoagulation management in cardiac surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, Volume: 34, Issue:1 Topics: Anticoagulants; Aprotinin; Aspirin; Cardiac Surgical Procedures; Clopidogrel; Contraindications; Evi	2008
Guideline on antiplatelet and anticoagulation management in cardiac surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, Volume: 34, Issue:1 Topics: Anticoagulants; Aprotinin; Aspirin; Cardiac Surgical Procedures; Clopidogrel; Contraindications; Evi	2008
Guideline on antiplatelet and anticoagulation management in cardiac surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, Volume: 34, Issue:1 Topics: Anticoagulants; Aprotinin; Aspirin; Cardiac Surgical Procedures; Clopidogrel; Contraindications; Evi	2008
Limiting excessive postoperative blood transfusion after cardiac procedures. A review. Texas Heart Institute journal, 1995, Volume: 22, Issue:3 Topics: Aspirin; Blood Coagulation Tests; Blood Loss, Surgical; Blood Transfusion; Cardiopulmonary Bypass; H	1995
Aspirin, a silent risk factor in urology. Scandinavian journal of urology and nephrology, 1995, Volume: 29, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Hemostasis; Humans; Lithotripsy; Male; Postoperati	1995
Hemorrhage and the use of blood products after adult cardiac operations: myths and realities. The Annals of thoracic surgery, 1996, Volume: 62, Issue:6 Topics: Adult; Aspirin; Blood Loss, Surgical; Blood Transfusion; Cardiac Surgical Procedures; Drainage; Huma	1996
A meta-analysis of thromboembolic prophylaxis following elective total hip arthroplasty. The Journal of bone and joint surgery. American volume, 2000, Volume: 82-A, Issue:7 Topics: Aged; Anticoagulants; Arthroplasty, Replacement, Hip; Aspirin; Chemoprevention; Confidence Intervals	2000
[Treatment of the massive suprachoroidal hemorrhages]. Archivos de la Sociedad Espanola de Oftalmologia, 2001, Volume: 76, Issue:4 Topics: Age Factors; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Blindness; Cataract Extraction; Comor	2001
What should we do with aspirin, NSAIDs, and glycoprotein-receptor inhibitors? International anesthesiology clinics, 2002,Spring, Volume: 40, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Homeostasis; Humans; Pain, Postop	2002

Article	Year
Rationale and design of the safe and timely antithrombotic removal - ticagrelor (STAR-T) trial: A prospective, multi-center, double-blind, randomized controlled trial evaluating reductions in postoperative bleeding with intraoperative removal of ticagrelo American heart journal, 2022, Volume: 245 Topics: Adenosine; Aspirin; Ataxia Telangiectasia Mutated Proteins; Fibrinolytic Agents; Humans; Platelet Ag	2022
Continuation of low-dose acetylsalicylic acid during perioperative period of laparoscopic inguinal hernia repair is safe: results of a prospective clinical trial. Hernia : the journal of hernias and abdominal wall surgery, 2019, Volume: 23, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Dose-Response Relation	2019
Cold Snare Polypectomy in Patients Taking Dual Antiplatelet Therapy: A Randomized Trial of Discontinuation of Thienopyridines. Clinical and translational gastroenterology, 2019, Volume: 10, Issue:10 Topics: Aged; Aspirin; Atherosclerosis; Blood Loss, Surgical; Colonic Polyps; Colonoscopy; Colorectal Neopla	2019
Platelet Reactivity in Patients With Acute Coronary Syndromes Awaiting Surgical Revascularization. Journal of the American College of Cardiology, 2021, 03-16, Volume: 77, Issue:10 Topics: Acute Coronary Syndrome; Aged; Aspirin; Blood Coagulation Tests; Blood Transfusion; Coronary Artery	2021
Sex Differences Among Patients With High Risk Receiving Ticagrelor With or Without Aspirin After Percutaneous Coronary Intervention: A Subgroup Analysis of the TWILIGHT Randomized Clinical Trial. JAMA cardiology, 2021, 09-01, Volume: 6, Issue:9 Topics: Aged; Aspirin; Coronary Angiography; Coronary Artery Disease; Drug Therapy, Combination; Female; Glo	2021
Decreased Serum Albumin Predicts Bleeding Events in Patients on Antiplatelet Therapy After Percutaneous Coronary Intervention. Circulation journal : official journal of the Japanese Circulation Society, 2017, Jun-23, Volume: 81, Issue:7 Topics: Aged; Aged, 80 and over; Aspirin; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervent	2017
Characterization of the Average Daily Ischemic and Bleeding Risk After Primary PCI for STEMI. Journal of the American College of Cardiology, 2017, Oct-10, Volume: 70, Issue:15 Topics: Aged; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Percutaneous Cor	2017
Effect of Sustained Use of Aspirin until the Time of Surgery on Outcomes following Coronary Artery Bypass Grafting: A Randomized Clinical Trial. The Thoracic and cardiovascular surgeon, 2018, Volume: 66, Issue:6 Topics: Aged; Aspirin; Blood Loss, Surgical; Cardiovascular Agents; Coronary Artery Bypass; Coronary Artery	2018
Effect of aspirin in vascular surgery in patients from a randomized clinical trial (POISE-2). The British journal of surgery, 2018, Volume: 105, Issue:12 Topics: Aged; Aspirin; Constriction, Pathologic; Female; Humans; Male; Myocardial Infarction; Perioperative	2018
Preoperative antiplatelet drugs on the hemorrhage and allogenic blood transfusion condition after coronary artery bypass graft surgery. Pakistan journal of pharmaceutical sciences, 2018, Volume: 31, Issue:6(Special) Topics: Adult; Aged; Aspirin; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass;	2018
Randomized trial of ticagrelor vs. aspirin in patients after coronary artery bypass grafting: the TiCAB trial. European heart journal, 2019, 08-01, Volume: 40, Issue:29 Topics: Aged; Aspirin; Coronary Artery Bypass; Double-Blind Method; Early Termination of Clinical Trials; Fe	2019
Comparison of aspirin plus heparin with heparin alone on asymptomatic perioperative deep vein thrombosis in candidates for elective off-pump coronary artery bypass graft: a randomized clinical trial. Cardiology journal, 2013, Volume: 20, Issue:2 Topics: Aged; Anticoagulants; Aspirin; Coronary Artery Bypass, Off-Pump; Double-Blind Method; Drug Therapy,	2013
Short-term follow-up of tirofiban as alternative therapy for urgent surgery patients with an implanted coronary drug-eluting stent after ST-elevation myocardial infarction. Coronary artery disease, 2013, Volume: 24, Issue:6 Topics: Aged; Aspirin; China; Clopidogrel; Drug Administration Schedule; Drug Substitution; Drug Therapy, Co	2013
[Clinical evaluation of influence of aspirin on post-operative bleeding after tooth extraction in the elderly]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 2013, Volume: 48, Issue:5 Topics: Aged; Aged, 80 and over; Anesthesia, Local; Aspirin; Female; Humans; Lidocaine; Male; Middle Aged; O	2013
Assessment of the risk of haemorrhage and its control following minor oral surgical procedures in patients on anti-platelet therapy: a prospective study. International journal of oral and maxillofacial surgery, 2014, Volume: 43, Issue:1 Topics: Adult; Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Female; Hemostasis, Surgical; Humans; Male;	2014
[Effectiveness and safety of tranexamic acid in patients receiving on-pump coronary artery bypass grafting without clopidogrel and aspirin cessation]. Zhonghua wai ke za zhi [Chinese journal of surgery], 2013, Jun-01, Volume: 51, Issue:6 Topics: Aged; Aged, 80 and over; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Female; Hu	2013
Aspirin in patients undergoing noncardiac surgery. The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16 Topics: Aged; Aspirin; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Peri	2014
Aspirin in patients undergoing noncardiac surgery. The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16 Topics: Aged; Aspirin; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Peri	2014
Aspirin in patients undergoing noncardiac surgery. The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16 Topics: Aged; Aspirin; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Peri	2014
Aspirin in patients undergoing noncardiac surgery. The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16 Topics: Aged; Aspirin; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Peri	2014
Aspirin in patients undergoing noncardiac surgery. The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16 Topics: Aged; Aspirin; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Peri	2014
Aspirin in patients undergoing noncardiac surgery. The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16 Topics: Aged; Aspirin; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Peri	2014
Aspirin in patients undergoing noncardiac surgery. The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16 Topics: Aged; Aspirin; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Peri	2014
Aspirin in patients undergoing noncardiac surgery. The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16 Topics: Aged; Aspirin; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Peri	2014
Aspirin in patients undergoing noncardiac surgery. The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16 Topics: Aged; Aspirin; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Peri	2014
Does rectal indomethacin given for prevention of post-ERCP pancreatitis increase bleeding after biliary endoscopic sphincterotomy or cardiovascular mortality?: Post hoc analysis using prospective clinical trial data. Medicine, 2014, Volume: 93, Issue:26 Topics: Administration, Rectal; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; C	2014
[Perioperative acetylsalicylic acid and clonidine in noncardiac surgery patients (POISE-2 trial)]. Revista espanola de anestesiologia y reanimacion, 2015, Volume: 62, Issue:5 Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Clo	2015
Preoperative platelet aggregation predicts perioperative blood loss and rethoracotomy for bleeding in patients receiving dual antiplatelet treatment prior to coronary surgery. Thrombosis research, 2015, Volume: 136, Issue:3 Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Drug Combinations; Female; Human	2015
The use of a biologic topical haemostatic agent (TachoSil(®)) for the prevention of postoperative bleeding in patients on antithrombotic therapy undergoing thyroid surgery: A randomised controlled pilot trial. International journal of surgery (London, England), 2015, Volume: 20 Topics: Administration, Topical; Aged; Aspirin; Biological Products; Drug Combinations; Female; Fibrinogen;	2015
Ankaferd blood stopper decreases postoperative bleeding and number of transfusions in patients treated with clopidogrel: a double-blind, placebo-controlled, randomized clinical trial. The heart surgery forum, 2015, Jun-26, Volume: 18, Issue:3 Topics: Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Double-Blind Method; Female;	2015
Stopping antiplatelet medication before coronary artery bypass graft surgery: is there an optimal timing to minimize bleeding? European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2015, Volume: 48, Issue:4 Topics: Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; D	2015
Effect of Preoperative Aspirin Replacement With Enoxaparin in Patients Undergoing Primary Isolated On-Pump Coronary Artery Bypass Grafting. The American journal of cardiology, 2016, Feb-15, Volume: 117, Issue:4 Topics: Aged; Anticoagulants; Aspirin; Coronary Artery Bypass; Coronary Artery Disease; Dose-Response Relati	2016
Stopping vs. Continuing Aspirin before Coronary Artery Surgery. The New England journal of medicine, 2016, 02-25, Volume: 374, Issue:8 Topics: Aged; Aspirin; Blood Transfusion; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Lengt	2016
Safety of Preoperative Use of Ticagrelor With or Without Aspirin Compared With Aspirin Alone in Patients With Acute Coronary Syndromes Undergoing Coronary Artery Bypass Grafting. JAMA cardiology, 2016, 11-01, Volume: 1, Issue:8 Topics: Acute Coronary Syndrome; Adenosine; Adult; Aged; Aged, 80 and over; Aspirin; Coronary Artery Bypass;	2016
Mobile pump deep vein thrombosis prophylaxis: just say no to drugs. The bone & joint journal, 2017, Volume: 99-B, Issue:1 Supple A Topics: Adult; Aged; Ambulatory Care; Anticoagulants; Arthroplasty, Replacement; Aspirin; Combined Modality	2017
Aspirin use and post-operative bleeding from dental extractions. Journal of dental research, 2008, Volume: 87, Issue:8 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bleeding Time; Female; Hemostasis; Humans;	2008
To continue or discontinue aspirin in the perioperative period: a randomized, controlled clinical trial. British journal of anaesthesia, 2010, Volume: 104, Issue:3 Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Cardiovascular Diseases; Double-Blind Method	2010
To continue or discontinue aspirin in the perioperative period: a randomized, controlled clinical trial. British journal of anaesthesia, 2010, Volume: 104, Issue:3 Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Cardiovascular Diseases; Double-Blind Method	2010
To continue or discontinue aspirin in the perioperative period: a randomized, controlled clinical trial. British journal of anaesthesia, 2010, Volume: 104, Issue:3 Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Cardiovascular Diseases; Double-Blind Method	2010
To continue or discontinue aspirin in the perioperative period: a randomized, controlled clinical trial. British journal of anaesthesia, 2010, Volume: 104, Issue:3 Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Cardiovascular Diseases; Double-Blind Method	2010
Modified thromboelastography evaluation of platelet dysfunction in patients undergoing coronary artery surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2010, Volume: 37, Issue:6 Topics: Aged; Aspirin; Blood Platelet Disorders; Clopidogrel; Coronary Artery Bypass; Drug Administration Sc	2010
Practice considerations of early aspirin administration following coronary artery bypass surgery. The heart surgery forum, 2011, Volume: 14, Issue:1 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Comorbidity; Coronary Artery Bypass; Drug-Re	2011
A randomised controlled trial to evaluate and optimize the use of antiplatelet agents in the perioperative management in patients undergoing general and abdominal surgery--the APAP trial (ISRCTN45810007). BMC surgery, 2011, Mar-03, Volume: 11 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Cholecystectomy; Clinical Protocols; Colectomy;	2011
Impact of preoperative maintenance or interruption of aspirin on thrombotic and bleeding events after elective non-cardiac surgery: the multicentre, randomized, blinded, placebo-controlled, STRATAGEM trial. British journal of anaesthesia, 2011, Volume: 107, Issue:6 Topics: Aged; Aspirin; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; Platelet Aggregation	2011
A randomised controlled pilot trial to evaluate and optimize the use of anti-platelet agents in the perioperative management in patients undergoing general and abdominal surgery--the APAP trial (ISRCTN45810007). Langenbeck's archives of surgery, 2012, Volume: 397, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Cholecystectomy; Colorectal Surgery;	2012
Dabigatran etexilate and concomitant use of non-steroidal anti-inflammatory drugs or acetylsalicylic acid in patients undergoing total hip and total knee arthroplasty: no increased risk of bleeding. Thrombosis and haemostasis, 2012, Volume: 108, Issue:1 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Arthroplasty, Replace	2012
Effects of preoperative aspirin in coronary artery bypass grafting: a double-blind, placebo-controlled, randomized trial. The Journal of thoracic and cardiovascular surgery, 2012, Volume: 144, Issue:1 Topics: Aged; Aspirin; Chi-Square Distribution; Coronary Artery Bypass; Coronary Artery Disease; Double-Blin	2012
The effects of combined oral anticoagulant-aspirin therapy in patients undergoing tooth extractions: a prospective study. Journal of the American Dental Association (1939), 2012, Volume: 143, Issue:7 Topics: Acenocoumarol; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anticoagulants; Aspirin; Chi-Sq	2012
Effect of acetylsalicylic acid usage and platelet transfusion on postoperative hemorrhage and activities of daily living in patients with acute intracerebral hemorrhage. Journal of neurosurgery, 2013, Volume: 118, Issue:1 Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Aspirin; Basal Ganglia; Craniotomy; Doub	2013
Acetylsalicylic acid treatment until surgery reduces oxidative stress and inflammation in patients undergoing coronary artery bypass grafting. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2013, Volume: 43, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Aspirin; C-Reactive Protein; Coronary Artery Bypass; Dinoprost; Drug	2013
Single-dose tranexamic acid reduces postoperative bleeding after coronary surgery in patients treated with aspirin until surgery. Anesthesia and analgesia, 2003, Volume: 96, Issue:4 Topics: Aged; Anticoagulants; Antifibrinolytic Agents; Aspirin; Blood Coagulation Tests; Blood Transfusion;	2003
Single-dose tranexamic acid reduces postoperative bleeding after coronary surgery in patients treated with aspirin until surgery. Anesthesia and analgesia, 2003, Volume: 96, Issue:4 Topics: Aged; Anticoagulants; Antifibrinolytic Agents; Aspirin; Blood Coagulation Tests; Blood Transfusion;	2003
Single-dose tranexamic acid reduces postoperative bleeding after coronary surgery in patients treated with aspirin until surgery. Anesthesia and analgesia, 2003, Volume: 96, Issue:4 Topics: Aged; Anticoagulants; Antifibrinolytic Agents; Aspirin; Blood Coagulation Tests; Blood Transfusion;	2003
Single-dose tranexamic acid reduces postoperative bleeding after coronary surgery in patients treated with aspirin until surgery. Anesthesia and analgesia, 2003, Volume: 96, Issue:4 Topics: Aged; Anticoagulants; Antifibrinolytic Agents; Aspirin; Blood Coagulation Tests; Blood Transfusion;	2003
Prophylactic treatment with desmopressin does not reduce postoperative bleeding after coronary surgery in patients treated with aspirin before surgery. Anesthesia and analgesia, 2004, Volume: 98, Issue:3 Topics: Aged; Anesthesia; Anticoagulants; Aspirin; Blood Transfusion; Coronary Artery Bypass; Deamino Argini	2004
A comparison of Plateletworks and platelet aggregometry for the assessment of aspirin-related platelet dysfunction in cardiac surgical patients. Journal of cardiothoracic and vascular anesthesia, 2004, Volume: 18, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cardiac Surgical Procedures; Female; Human	2004
Single-arm study of bridging therapy with low-molecular-weight heparin for patients at risk of arterial embolism who require temporary interruption of warfarin. Circulation, 2004, Sep-21, Volume: 110, Issue:12 Topics: Anticoagulants; Arterial Occlusive Diseases; Aspirin; Atrial Fibrillation; Blood Loss, Surgical; Coh	2004
Emboli rate during and early after carotid endarterectomy after a single preoperative dose of 120 mg acetylsalicylic acid--a prospective double-blind placebo controlled randomised trial. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2005, Volume: 29, Issue:2 Topics: Aged; Aged, 80 and over; Aspirin; Dose-Response Relationship, Drug; Double-Blind Method; Endarterect	2005
Risk of major haemorrhage in patients after infrainguinal venous bypass surgery: therapeutic consequences? The Dutch BOA (Bypass Oral Anticoagulants or Aspirin) Study. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2005, Volume: 30, Issue:2 Topics: Administration, Oral; Aged; Anticoagulants; Arteriosclerosis; Aspirin; Female; Fibrinolytic Agents;	2005
Clopidogrel and bleeding after coronary artery bypass graft surgery. The Annals of thoracic surgery, 2005, Volume: 80, Issue:3 Topics: Aged; Aspirin; Blood Transfusion; Blood Volume; Clopidogrel; Coronary Artery Bypass; Drug Therapy, C	2005
Prediction of the excessive perioperative bleeding in patients undergoing coronary artery bypass grafting: role of aspirin and platelet glycoprotein IIIa polymorphism. The Journal of thoracic and cardiovascular surgery, 2005, Volume: 130, Issue:3 Topics: Alleles; Aspirin; Blood Loss, Surgical; Coronary Artery Bypass; Double-Blind Method; Female; Humans;	2005
Aprotinin shows both hemostatic and antithrombotic effects during off-pump coronary artery bypass grafting. The Annals of thoracic surgery, 2006, Volume: 81, Issue:1 Topics: Aprotinin; Aspirin; Biomarkers; Blood Coagulation Tests; Blood Loss, Surgical; Coronary Artery Bypas	2006
Normalization of platelet reactivity in clopidogrel-treated subjects. Journal of thrombosis and haemostasis : JTH, 2007, Volume: 5, Issue:1 Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Collagen; Cor	2007
Comparison of two antiplatelet regimens (aspirin alone versus aspirin + ticlopidine or clopidogrel) after intracoronary implantation of a carbofilm-coated stent. The American journal of cardiology, 2007, Apr-15, Volume: 99, Issue:8 Topics: Aspirin; Carbon; Cause of Death; Clopidogrel; Coated Materials, Biocompatible; Coronary Disease; Cor	2007
Early initiation of aspirin after prostate and transurethral bladder surgeries is not associated with increased incidence of postoperative bleeding: a prospective, randomized trial. The Journal of urology, 2007, Volume: 178, Issue:2 Topics: Aged; Aged, 80 and over; Aspirin; Cystoscopy; Drug Administration Schedule; Female; Fibrinolytic Age	2007
Early initiation of aspirin after prostate and transurethral bladder surgeries is not associated with increased incidence of postoperative bleeding: a prospective, randomized trial. The Journal of urology, 2007, Volume: 178, Issue:2 Topics: Aged; Aged, 80 and over; Aspirin; Cystoscopy; Drug Administration Schedule; Female; Fibrinolytic Age	2007
Early initiation of aspirin after prostate and transurethral bladder surgeries is not associated with increased incidence of postoperative bleeding: a prospective, randomized trial. The Journal of urology, 2007, Volume: 178, Issue:2 Topics: Aged; Aged, 80 and over; Aspirin; Cystoscopy; Drug Administration Schedule; Female; Fibrinolytic Age	2007
Early initiation of aspirin after prostate and transurethral bladder surgeries is not associated with increased incidence of postoperative bleeding: a prospective, randomized trial. The Journal of urology, 2007, Volume: 178, Issue:2 Topics: Aged; Aged, 80 and over; Aspirin; Cystoscopy; Drug Administration Schedule; Female; Fibrinolytic Age	2007
Low-intensity oral anticoagulant plus low-dose aspirin during the first six months versus standard-intensity oral anticoagulant therapy after mechanical heart valve replacement: a pilot study of low-intensity warfarin and aspirin in cardiac prostheses (LI Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2007, Volume: 13, Issue:3 Topics: Aged; Anticoagulants; Aortic Valve; Aspirin; Female; Heart Valve Prosthesis Implantation; Hemorrhage	2007
Heparin anticoagulation in patients undergoing off-pump and on-pump coronary bypass surgery. Journal of anesthesia, 2007, Volume: 21, Issue:3 Topics: Aspirin; Blood Coagulation; Blood Platelets; Blood Transfusion; Coronary Artery Bypass; Coronary Art	2007
The effect of herbal medicines on platelet function: an in vivo experiment and review of the literature. Plastic and reconstructive surgery, 2007, Volume: 120, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Coagulation; Blood Coagulation Tests; Blood Platelets	2007
Lack of complications in minor skin lesion excisions in patients taking aspirin or warfarin products. The American surgeon, 2008, Volume: 74, Issue:4 Topics: Aged; Anticoagulants; Aspirin; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Post	2008
Complications of cutaneous surgery in patients who are taking warfarin, aspirin, or nonsteroidal anti-inflammatory drugs. Archives of dermatology, 1996, Volume: 132, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dermat	1996
The use of low-dose aprotinin, epsilon-aminocaproic acid or tranexamic acid for prevention of mediastinal bleeding in patients receiving aspirin before coronary artery bypass operations. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 1997, Volume: 11, Issue:4 Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Aspirin; Coronary Artery Bypass; Dose-Respons	1997
Aprotinin counterbalances an increased risk of peri-operative hemorrhage in CABG patients pre-treated with Aspirin. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 1998, Volume: 14, Issue:4 Topics: Aprotinin; Aspirin; Blood Loss, Surgical; Coronary Artery Bypass; Creatine Kinase; Double-Blind Meth	1998
Strategy for balancing anticoagulation and hemostasis in aortocoronary bypass surgery: blood conservation and graft patency. Japanese circulation journal, 1999, Volume: 63, Issue:3 Topics: Adult; Anticoagulants; Aprotinin; Aspirin; Coronary Artery Bypass; Drug Administration Schedule; Hem	1999
Comparison of two doses of aprotinin in patients receiving aspirin before coronary bypass surgery. Perfusion, 2000, Volume: 15, Issue:2 Topics: Adult; Aged; Aprotinin; Aspirin; Blood Loss, Surgical; Blood Transfusion; Cardiopulmonary Bypass; Co	2000
The effect of low-dose acetylsalicylic acid on bleeding after transurethral prostatectomy--a prospective, randomized, double-blind, placebo-controlled study. Scandinavian journal of urology and nephrology, 2000, Volume: 34, Issue:3 Topics: Aged; Aspirin; Blood Loss, Surgical; Double-Blind Method; Humans; Male; Postoperative Hemorrhage; Po	2000
The effects of recent aspirin ingestion on platelet function in cardiac surgical patients. Journal of cardiothoracic and vascular anesthesia, 2001, Volume: 15, Issue:1 Topics: Aged; Anesthesia; Aspirin; Blood Platelets; Cardiac Surgical Procedures; Female; Humans; Male; Middl	2001
The hemostatic effects of warfarin titration in post CABG patients in comparison to placebo treatment. Journal of thrombosis and thrombolysis, 2001, Volume: 11, Issue:2 Topics: Adult; Aged; Anticoagulants; Aspirin; Coronary Artery Bypass; Coronary Disease; Dose-Response Relati	2001
Low-dose postoperative aprotinin reduces mediastinal drainage and blood product use in patients undergoing primary coronary artery bypass grafting who are taking aspirin: a prospective, randomized, double-blind, placebo-controlled trial. The Journal of thoracic and cardiovascular surgery, 2001, Volume: 122, Issue:3 Topics: Aged; Aprotinin; Aspirin; Blood Component Transfusion; Combined Modality Therapy; Coronary Artery By	2001
Does withholding aspirin for one week reduce the risk of post-sphincterotomy bleeding? Alimentary pharmacology & therapeutics, 2002, Volume: 16, Issue:5 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Comorbidity; Female; Humans; Incidence; Male	2002
The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting. Journal of the American College of Cardiology, 2002, Jul-17, Volume: 40, Issue:2 Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Female; Humans; In	2002

aspirin and Blood Loss, Postoperative

Research Excerpts

Research

Studies (402)

Authors

Clinical Trials (34)

Trial Overview

Trial Outcomes

Number of Participants With BARC Type 2, 3, or 5

Number of Participants With Ischemic Episode

Composite of All-cause Mortality and Nonfatal MI

BARC Bleeding

Calculated Blood Loss

Mean Concentration of TxA in Plasma Collected From Participants

Median Number of Hours Participants Spent in ICU

Median Volume of Mediastinal Fluid Collected From Participants

Number of Participants With Mortality

Number of Participants With RBC Transfusion

Number of Participants With Re-operation for Bleeding or Tamponade

Number of Participants With Seizures

Expression of GALGT2 as Demonstrated by Immunofluorescent Staining With Anti-CT Epitope Antibodies or WFA Lectin in Muscle Biopsy Sections at 120 Days Post Injection (Cohort 1) and 90 Days Post-injection (Cohort 2).

GALGT2 Protein Expression Quantified by Western Blot and Assessed by Densitometry in Muscle Biopsy Tissue at 120 Days Post-injection (Cohort 1) and 90 Days Post-injection (Cohort 2)

Number of Unanticipated Grade III or Higher Treatment-Related Toxicities

Number of Meters Walked During the 6 Minute Walk Test

Score of Muscle Function Using the The North Star Ambulatory Assessment (NSAA).

Strength of the Bilateral Knee Flexors and Extensors During the Maximal Voluntary Isometric Strength Test.

Time Taken to Walk 100 Meters During the 100 Meter Walk Test.

Time Taken to Walk 100 Meters During the 100 Meter Walk Test.

Reviews

Trials

Other Studies

Authors	Studies
Ndrepepa, G	2
Neumann, FJ	1
Menichelli, M	1
Holdenrieder, S	2
Richardt, G	1
Mayer, K	1
Cassese, S	2
Xhepa, E	1
Kufner, S	1
Wiebe, J	1
Joner, M	1
Kessler, T	1
Laugwitz, KL	1
Schunkert, H	2
Kastrati, A	3
Gibson, CM	2
Mack, MJ	1
Lee, VT	1
Schneider, DJ	1
Sellke, FW	1
Ohman, EM	2
Thourani, VH	2
Doros, G	1
Kroger, H	1
Cutlip, DE	1
Deliargyris, EN	2
Mishu, MD	1
Zolper, EG	1
Dekker, PK	1
Fleury, CM	1
Bekeny, JC	1
Fan, KL	1
Attinger, CE	1
Evans, KK	1
Valvano, M	1
Fabiani, S	1
Magistroni, M	1
Mancusi, A	1
Longo, S	1
Stefanelli, G	1