Page last updated: 2024-10-23

aspirin and Bleb

aspirin has been researched along with Bleb in 5 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"Aspirin is a unique nonsteroidal anti-inflammatory drug; at high doses (aspirin(high), 1g), it is anti-inflammatory stemming from the inhibition of cyclooxygenase and proinflammatory signaling pathways including NF-kappaB, but is cardioprotective at lower doses (aspirin(low), 75 mg)."2.74Effects of low-dose aspirin on acute inflammatory responses in humans. ( Bellingan, G; Colville-Nash, P; de Souza, P; Gilroy, DW; Hobbs, A; Morris, T; Newson, J; Stables, M; Warner, T, 2009)
" The mean Cmax (maximum concentration) of total, unbound salicylic acid was 9."1.30Microdialysis vs. suction blister technique for in vivo sampling of pharmacokinetics in the human dermis. ( Benfeldt, E; Menné, T; Serup, J, 1999)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19903 (60.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Morris, T1
Stables, M1
Hobbs, A1
de Souza, P1
Colville-Nash, P1
Warner, T1
Newson, J1
Bellingan, G1
Gilroy, DW1
TUFFANELLI, DL1
DUBOIS, EL1
Oikarinen, A1
Viinikka, L1
Rytsälä, H1
Kiistala, U1
Ylikorkala, O1
Benfeldt, E1
Serup, J1
Menné, T1
Tandon, GS1
Shukla, RC1
Benjamin, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Impact of Aspirin Dose Modification on the Innate Immune Response - Will Lower Dose Aspirin Therapy Reduce the Response to Endotoxin[NCT03869268]Phase 472 participants (Actual)Interventional2019-04-24Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for aspirin and Bleb

ArticleYear
Effects of low-dose aspirin on acute inflammatory responses in humans.
    Journal of immunology (Baltimore, Md. : 1950), 2009, Aug-01, Volume: 183, Issue:3

    Topics: Acute Disease; Aspirin; Blister; Cantharidin; Cell Adhesion; Chemotaxis, Leukocyte; Dose-Response Re

2009
Prostacyclin, thromboxane and prostaglandin F2 alpha in suction blister fluid of human skin: effect of systemic aspirin and local glucocorticosteroid treatment.
    Life sciences, 1981, Jul-27, Volume: 29, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Betamethasone; Blister; Clobetasol; Dinoprost; Epopros

1981
Effect of bradykinin and its antagonists on superficial and deep pain in human subjects and dogs.
    Indian journal of physiology and pharmacology, 1966, Volume: 10, Issue:3

    Topics: Acetylcholine; Animals; Arachnida; Aspirin; Blister; Bradykinin; Clinical Trials as Topic; Codeine;

1966

Other Studies

2 other studies available for aspirin and Bleb

ArticleYear
CUTANEOUS MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS.
    Archives of dermatology, 1964, Volume: 90

    Topics: Adrenal Cortex Hormones; Alopecia; Anti-Bacterial Agents; Antimalarials; Aspirin; Blister; Drug Erup

1964
Microdialysis vs. suction blister technique for in vivo sampling of pharmacokinetics in the human dermis.
    Acta dermato-venereologica, 1999, Volume: 79, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blister; Dermis; Female; Humans; Male; Micr

1999