aspirin has been researched along with Bleb in 5 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aspirin is a unique nonsteroidal anti-inflammatory drug; at high doses (aspirin(high), 1g), it is anti-inflammatory stemming from the inhibition of cyclooxygenase and proinflammatory signaling pathways including NF-kappaB, but is cardioprotective at lower doses (aspirin(low), 75 mg)." | 2.74 | Effects of low-dose aspirin on acute inflammatory responses in humans. ( Bellingan, G; Colville-Nash, P; de Souza, P; Gilroy, DW; Hobbs, A; Morris, T; Newson, J; Stables, M; Warner, T, 2009) |
| " The mean Cmax (maximum concentration) of total, unbound salicylic acid was 9." | 1.30 | Microdialysis vs. suction blister technique for in vivo sampling of pharmacokinetics in the human dermis. ( Benfeldt, E; Menné, T; Serup, J, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morris, T | 1 |
| Stables, M | 1 |
| Hobbs, A | 1 |
| de Souza, P | 1 |
| Colville-Nash, P | 1 |
| Warner, T | 1 |
| Newson, J | 1 |
| Bellingan, G | 1 |
| Gilroy, DW | 1 |
| TUFFANELLI, DL | 1 |
| DUBOIS, EL | 1 |
| Oikarinen, A | 1 |
| Viinikka, L | 1 |
| Rytsälä, H | 1 |
| Kiistala, U | 1 |
| Ylikorkala, O | 1 |
| Benfeldt, E | 1 |
| Serup, J | 1 |
| Menné, T | 1 |
| Tandon, GS | 1 |
| Shukla, RC | 1 |
| Benjamin, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Impact of Aspirin Dose Modification on the Innate Immune Response - Will Lower Dose Aspirin Therapy Reduce the Response to Endotoxin[NCT03869268] | Phase 4 | 72 participants (Actual) | Interventional | 2019-04-24 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for aspirin and Bleb
| Article | Year |
|---|---|
Effects of low-dose aspirin on acute inflammatory responses in humans.
Topics: Acute Disease; Aspirin; Blister; Cantharidin; Cell Adhesion; Chemotaxis, Leukocyte; Dose-Response Re | 2009 |
Prostacyclin, thromboxane and prostaglandin F2 alpha in suction blister fluid of human skin: effect of systemic aspirin and local glucocorticosteroid treatment.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Betamethasone; Blister; Clobetasol; Dinoprost; Epopros | 1981 |
Effect of bradykinin and its antagonists on superficial and deep pain in human subjects and dogs.
Topics: Acetylcholine; Animals; Arachnida; Aspirin; Blister; Bradykinin; Clinical Trials as Topic; Codeine; | 1966 |
2 other studies available for aspirin and Bleb
| Article | Year |
|---|---|
CUTANEOUS MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS.
Topics: Adrenal Cortex Hormones; Alopecia; Anti-Bacterial Agents; Antimalarials; Aspirin; Blister; Drug Erup | 1964 |
Microdialysis vs. suction blister technique for in vivo sampling of pharmacokinetics in the human dermis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blister; Dermis; Female; Humans; Male; Micr | 1999 |