Page last updated: 2024-10-23

aspirin and Bile Duct Obstruction

aspirin has been researched along with Bile Duct Obstruction in 20 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"The aspirin for metal stents in malignant distal common bile duct obstruction (AIMS) study should determine the efficacy of aspirin in maintaining metal-stent patency in patients with malignant distal CBD obstructive."9.34Aspirin for metal stent in malignant distal common bile duct obstruction (AIMS): study protocol for a multicenter randomized controlled trial. ( Choi, JH; Choi, YH; Kim, YT; Lee, KJ; Lee, SH; Paik, WH; Ryu, JK; Shin, BS; You, MS, 2020)
"In this study the severity of aspirin-induced gastric mucosal damage was investigated in rats with obstructive cholestasis."7.70Enhancement of aspirin-induced gastric damage by cholestasis in rats. ( Alikhani, Z; Dehpour, AR; Ghaffari, K; Mani, AR; Nowroozi, A; Sabbagh, B; Sadr, S; Sharif, A; Toor Savadkoohi, S; Zeinoddini, M, 1998)
"The aspirin for metal stents in malignant distal common bile duct obstruction (AIMS) study should determine the efficacy of aspirin in maintaining metal-stent patency in patients with malignant distal CBD obstructive."5.34Aspirin for metal stent in malignant distal common bile duct obstruction (AIMS): study protocol for a multicenter randomized controlled trial. ( Choi, JH; Choi, YH; Kim, YT; Lee, KJ; Lee, SH; Paik, WH; Ryu, JK; Shin, BS; You, MS, 2020)
"In this study the severity of aspirin-induced gastric mucosal damage was investigated in rats with obstructive cholestasis."3.70Enhancement of aspirin-induced gastric damage by cholestasis in rats. ( Alikhani, Z; Dehpour, AR; Ghaffari, K; Mani, AR; Nowroozi, A; Sabbagh, B; Sadr, S; Sharif, A; Toor Savadkoohi, S; Zeinoddini, M, 1998)
" However, severe and numerous adverse events are associated with vismodegib use."2.52Cholestatic hepatic injury associated with vismodegib, aspirin, and naproxen use: a case study and review of vismodegib safety. ( Ash, MM; Jolly, PS, 2015)
"Prednisolone was initiated with clinical and analytical improvement."1.56Boundaries of a systemic disease: a protean presentation of giant cell arteritis. ( Brotas, V; Camara, L; Mesquita, A; Patrício, C, 2020)
"Atypical onset of Kawasaki disease (KD) is a frequent problem leading to diagnostic mistake."1.35Acute cholestasis: atypical onset of Kawasaki disease. ( Angelone, DF; Ausili, E; De Rosa, G; Focarelli, B; Ranno, O; Schiavino, A; Valentini, P, 2008)
"Other signs typical of the Kawasaki disease occurred a few days later and permitted diagnosis."1.32Painful jaundice revealing Kawasaki disease in a young man. ( Disdier, P; Ene, N; Granel, B; Habib, G; Igual, JP; Serratrice, J; Weiller, PJ, 2004)
"Cholestasis is one of the major complications of parenteral nutrition."1.30The effects of acetylsalicylic acid, interferon-alpha, and vitamin E on prevention of parenteral nutrition-associated cholestasis: an experimental study. ( Atik, E; Demircan, M; Gurer, EI; Gursoy, MH; Mutus, M; Turhan, F; Uguralp, S, 1999)
"Cholestasis is a frequent problem in patients on total parenteral nutrition (TPN) therapy."1.29The choleretic effect of nonsteroidal anti-inflammatory drugs in total parenteral nutrition-associated cholestasis. ( Dinari, G; Hackelman, B; Marcus, H; Nussinovitch, M; Zahavi, I, 1996)
"The charts of 238 patients with systemic lupus erythematosus (SLE) were reviewed."1.26The spectrum of liver disease in systemic lupus erythematosus. Report of 33 histologically-proved cases and review of the literature. ( Anuras, S; LaBrecque, DR; Runyon, BA, 1980)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19904 (20.00)18.7374
1990's6 (30.00)18.2507
2000's4 (20.00)29.6817
2010's2 (10.00)24.3611
2020's4 (20.00)2.80

Authors

AuthorsStudies
Choi, JH2
Lee, KJ2
Paik, WH2
Park, N1
Chun, JW1
Lee, SH2
Ryu, JK2
Kim, YT2
You, MS1
Choi, YH1
Shin, BS1
Mesquita, A1
Camara, L1
Patrício, C1
Brotas, V1
Gallerani, M1
Pala, M1
Fabbian, F1
De Giorgi, A1
Ash, MM1
Jolly, PS1
Jang, S1
Stevens, T1
Parsi, MA1
Lopez, R1
Vargo, JJ1
Wong, F1
Granel, B1
Serratrice, J1
Ene, N1
Igual, JP1
Habib, G1
Disdier, P1
Weiller, PJ1
Polat, A1
Emre, MH1
Valentini, P1
Ausili, E1
Schiavino, A1
Angelone, DF1
Focarelli, B1
De Rosa, G1
Ranno, O1
Kolts, BE1
Langfitt, M1
Runyon, BA1
LaBrecque, DR1
Anuras, S1
Desgripes, A1
Blanc, P1
Debray, D1
Carbajal, R1
Paupe, A1
Lenclen, R1
Olivier-Martin, M1
Nussinovitch, M1
Zahavi, I1
Marcus, H1
Hackelman, B1
Dinari, G1
Dehpour, AR1
Mani, AR1
Alikhani, Z1
Zeinoddini, M1
Toor Savadkoohi, S1
Ghaffari, K1
Sharif, A1
Sabbagh, B1
Nowroozi, A1
Sadr, S1
Demircan, M1
Uguralp, S1
Mutus, M1
Gurer, EI1
Atik, E1
Turhan, F1
Gursoy, MH1
Meyer, MI1
Kuhn, M1
Bühler, H1
Bertschinger, P1
Lai, MY1
Sung, JL1
Lin, WS1
How, SW1
Yu, JY1
Wang, TH1
Chen, DS1
Gal'perin, EI1
Tatishvili, GG1
Akhaladze, GG1
Sakevarashvili, GR1
Nasirov, FN1
Aref'ev, AE1
Monte, MJ1
Esteller, A1
Jimenez, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Aspirin on Patency of Metal Stent in Malignant Distal Bile Duct Obstruction[NCT03279809]52 participants (Actual)Interventional2017-10-12Terminated (stopped due to One grade 4 adverse event (AE) and common (47.2%) grade 3 AEs)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for aspirin and Bile Duct Obstruction

ArticleYear
Cholestatic hepatic injury associated with vismodegib, aspirin, and naproxen use: a case study and review of vismodegib safety.
    International journal of dermatology, 2015, Volume: 54, Issue:3

    Topics: Aged; Anilides; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Carcinoma,

2015
Liver and kidney diseases.
    Clinics in liver disease, 2002, Volume: 6, Issue:4

    Topics: Acetaminophen; Anemia, Sickle Cell; Animals; Aspirin; Cholestasis; Cysts; Glomerulonephritis, IGA; G

2002
Biochemical and morphological study of the liver injury induced by drugs and chemicals.
    Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1979, Volume: 78, Issue:6

    Topics: Alkaline Phosphatase; Aspirin; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Halothan

1979

Trials

2 trials available for aspirin and Bile Duct Obstruction

ArticleYear
Acetylsalicylic acid for metal stent in malignant distal common bile duct obstruction: A randomized controlled trial.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2022, Volume: 21, Issue:5

    Topics: Aspirin; Bile Duct Neoplasms; Cholangiopancreatography, Endoscopic Retrograde; Cholestasis; Humans;

2022
Aspirin for metal stent in malignant distal common bile duct obstruction (AIMS): study protocol for a multicenter randomized controlled trial.
    Trials, 2020, Jan-30, Volume: 21, Issue:1

    Topics: Aspirin; Cholangiopancreatography, Endoscopic Retrograde; Cholestasis; Common Bile Duct; Double-Blin

2020

Other Studies

15 other studies available for aspirin and Bile Duct Obstruction

ArticleYear
Boundaries of a systemic disease: a protean presentation of giant cell arteritis.
    BMJ case reports, 2020, Mar-25, Volume: 13, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cholestasis; Cough; Diagnosis, Differential; Drug

2020
Acute cholestasis as uncommon onset of Kawasaki disease: a case report.
    BMC gastroenterology, 2020, Oct-28, Volume: 20, Issue:1

    Topics: Adult; Aspirin; Child; Child, Preschool; Cholestasis; Edema; Fever; Humans; Male; Mucocutaneous Lymp

2020
Aspirin Use Is Associated With Reduced Risk of Occlusion of Metallic Biliary Stents.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2017, Volume: 15, Issue:3

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biliary Tract Surgical Procedures; Cholestas

2017
Painful jaundice revealing Kawasaki disease in a young man.
    Journal of gastroenterology and hepatology, 2004, Volume: 19, Issue:6

    Topics: Abdominal Pain; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cholestasis; Humans; I

2004
Effects of melatonin or acetylsalicylic acid on gastric oxidative stress after bile duct ligation in rats.
    Journal of gastroenterology, 2006, Volume: 41, Issue:5

    Topics: Animals; Aspirin; Bile Ducts; Catalase; Cholestasis; Disease Models, Animal; Glutathione Peroxidase;

2006
Acute cholestasis: atypical onset of Kawasaki disease.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2008, Volume: 40, Issue:7

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Cholestasis; Diagnosis, Diff

2008
Drugs and the liver.
    Comprehensive therapy, 1984, Volume: 10, Issue:12

    Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv

1984
The spectrum of liver disease in systemic lupus erythematosus. Report of 33 histologically-proved cases and review of the literature.
    The American journal of medicine, 1980, Volume: 69, Issue:2

    Topics: Adolescent; Adult; Aged; Aspirin; Biopsy; Chemical and Drug Induced Liver Injury; Child, Preschool;

1980
[Inaugural acute cholestasis of Kawasaki disease].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1996, Volume: 3, Issue:7

    Topics: Acute Disease; Adolescent; Aspirin; Cholestasis; Humans; Immunization, Passive; Male; Mucocutaneous

1996
The choleretic effect of nonsteroidal anti-inflammatory drugs in total parenteral nutrition-associated cholestasis.
    Israel journal of medical sciences, 1996, Volume: 32, Issue:12

    Topics: Amino Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile; Bile Acids and Salts;

1996
Enhancement of aspirin-induced gastric damage by cholestasis in rats.
    Fundamental & clinical pharmacology, 1998, Volume: 12, Issue:4

    Topics: Animals; Aspirin; Bile Ducts; Cholestasis; Disease Models, Animal; Gastric Mucosa; Irritants; Laparo

1998
The effects of acetylsalicylic acid, interferon-alpha, and vitamin E on prevention of parenteral nutrition-associated cholestasis: an experimental study.
    Journal of pediatric gastroenterology and nutrition, 1999, Volume: 28, Issue:3

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspart

1999
[Ticlopidine-induced cholestasis].
    Schweizerische medizinische Wochenschrift, 1999, Oct-02, Volume: 129, Issue:39

    Topics: Aged; Aged, 80 and over; Angina Pectoris; Aspirin; Chemical and Drug Induced Liver Injury; Cholestas

1999
[Disorders of organic hemodynamics of the liver and their correction in suppurative cholangitis].
    Khirurgiia, 1991, Issue:9

    Topics: Acute Disease; Animals; Aprotinin; Ascorbic Acid; Aspirin; Cholangitis; Cholestasis; Dextrans; Dipyr

1991
Acetylsalicylate-induced cholestasis, unrelated to biliary bile acid excretion, in the rabbit.
    Biomedica biochimica acta, 1988, Volume: 47, Issue:8

    Topics: Analgesics; Animals; Aspirin; Bicarbonates; Bile; Bile Acids and Salts; Chlorides; Cholestasis; Lysi

1988