Page last updated: 2024-10-23

aspirin and Bile Duct Cancer

aspirin has been researched along with Bile Duct Cancer in 21 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
" We aimed to examine aspirin use on cancer-specific survival in various BTC subtypes, including gallbladder cancer, ampulla of Vater cancer, and cholangiocarcinoma."8.02Postdiagnosis Aspirin Use Associated With Decreased Biliary Tract Cancer-Specific Mortality in a Large Nationwide Cohort. ( Chan, C; Chen, CJ; Chen, YJ; Hsieh, RJ; Huang, C; Huang, CP; Huang, YH; Jackson, SS; Koshiol, J; Lee, MH; Liao, SF; Liu, PC; Lu, SN; Shen, CY, 2021)
" Aspirin has many properties including anti-inflammation and anti-cancer."7.83Combination of Praziquantel and Aspirin Minimizes Liver Pathology of Hamster Opisthorchis viverrini Infection Associated Cholangiocarcinoma. ( Aukkanimart, R; Boonmars, T; Jiraporn, S; Loilome, W; Nadchanan, W; Namwat, N; Ruangjirachuporn, W; Sriraj, P; Sudsarn, P, 2016)
"Whether aspirin use is protective against cholangiocarcinoma (CCA) remains unclear."7.83Aspirin use and the risk of cholangiocarcinoma. ( Addissie, BD; Baichoo, E; Chaiteerakij, R; Choi, J; Ghoz, HM; Harmsen, WS; Olson, JE; Peeraphatdit, T; Roberts, LR; Therneau, TM, 2016)
"To investigate whether there is an inverse association between NSAIDs, including aspirin, and the development of cholangiocarcinoma and, for the first time in a Western population, between statin use and the development of cholangiocarcinoma."7.80Aspirin may prevent cholangiocarcinoma: a case-control study from the United kingdom. ( Burr, NE; Clark, A; Dennison, A; Hart, AR; Lewis, MP; Metcalfe, M; Phillips, M; Rhodes, M; Robinson, R; Rushbrook, S; Savva, S; Talboys, RJ, 2014)
"Cholangiocarcinoma is the second most common primary hepatic cancer, with a rising incidence worldwide."6.72A potential role for aspirin in the prevention and treatment of cholangiocarcinoma. ( Shen, X, 2021)
"Cholangiocarcinoma is the most common biliary duct malignancy and the second most common primary liver cancer, accounting for 10‑20% of hepatic malignancies."5.62Aspirin inhibits cholangiocarcinoma cell proliferation via cell cycle arrest in vitro and in vivo. ( Fujita, K; Gong, J; Iwama, H; Kobara, H; Liu, S; Masaki, T; Morishita, A; Nakahara, M; Nishiyama, N; Nonura, T; Okano, K; Shi, T; Suzuki, Y; Yoneyama, H, 2021)
" We aimed to examine aspirin use on cancer-specific survival in various BTC subtypes, including gallbladder cancer, ampulla of Vater cancer, and cholangiocarcinoma."4.02Postdiagnosis Aspirin Use Associated With Decreased Biliary Tract Cancer-Specific Mortality in a Large Nationwide Cohort. ( Chan, C; Chen, CJ; Chen, YJ; Hsieh, RJ; Huang, C; Huang, CP; Huang, YH; Jackson, SS; Koshiol, J; Lee, MH; Liao, SF; Liu, PC; Lu, SN; Shen, CY, 2021)
" Aspirin has many properties including anti-inflammation and anti-cancer."3.83Combination of Praziquantel and Aspirin Minimizes Liver Pathology of Hamster Opisthorchis viverrini Infection Associated Cholangiocarcinoma. ( Aukkanimart, R; Boonmars, T; Jiraporn, S; Loilome, W; Nadchanan, W; Namwat, N; Ruangjirachuporn, W; Sriraj, P; Sudsarn, P, 2016)
"Whether aspirin use is protective against cholangiocarcinoma (CCA) remains unclear."3.83Aspirin use and the risk of cholangiocarcinoma. ( Addissie, BD; Baichoo, E; Chaiteerakij, R; Choi, J; Ghoz, HM; Harmsen, WS; Olson, JE; Peeraphatdit, T; Roberts, LR; Therneau, TM, 2016)
"To investigate whether there is an inverse association between NSAIDs, including aspirin, and the development of cholangiocarcinoma and, for the first time in a Western population, between statin use and the development of cholangiocarcinoma."3.80Aspirin may prevent cholangiocarcinoma: a case-control study from the United kingdom. ( Burr, NE; Clark, A; Dennison, A; Hart, AR; Lewis, MP; Metcalfe, M; Phillips, M; Rhodes, M; Robinson, R; Rushbrook, S; Savva, S; Talboys, RJ, 2014)
"Cholangiocarcinoma is the second most common primary hepatic cancer, with a rising incidence worldwide."2.72A potential role for aspirin in the prevention and treatment of cholangiocarcinoma. ( Shen, X, 2021)
"Metformin was not associated with BTC risk (HR, 0."1.72Aspirin, Statins, Non-aspirin NSAIDs, Metformin, and the Risk of Biliary Cancer: A Swedish Population-Based Cohort Study. ( Borad, MJ; Brusselaers, N; Harmsen, WS; Marcano-Bonilla, L; Patel, T; Petersen, GM; Roberts, LR; Sadr-Azodi, O; Schleck, CD; Therneau, TM, 2022)
"Cholangiocarcinoma is the most common biliary duct malignancy and the second most common primary liver cancer, accounting for 10‑20% of hepatic malignancies."1.62Aspirin inhibits cholangiocarcinoma cell proliferation via cell cycle arrest in vitro and in vivo. ( Fujita, K; Gong, J; Iwama, H; Kobara, H; Liu, S; Masaki, T; Morishita, A; Nakahara, M; Nishiyama, N; Nonura, T; Okano, K; Shi, T; Suzuki, Y; Yoneyama, H, 2021)
"RECK functions as a metastasis suppressor in CCA; upregulation of RECK expression could provide a potential therapy to improve the prognosis of this type of cancer."1.37Downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is associated with enhanced expression of matrix metalloproteinases and cholangiocarcinoma metastases. ( Khuntikeo, N; Loilome, W; Namwat, N; Puapairoj, A; Puetkasichonpasutha, J; Sripa, B; Tassaneeyakul, W; Techasen, A; Wongkham, S; Yongvanit, P, 2011)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's13 (61.90)24.3611
2020's8 (38.10)2.80

Authors

AuthorsStudies
Choi, JH1
Lee, KJ1
Paik, WH1
Park, N1
Chun, JW1
Lee, SH1
Ryu, JK1
Kim, YT1
Marcano-Bonilla, L1
Schleck, CD1
Harmsen, WS2
Sadr-Azodi, O2
Borad, MJ1
Patel, T1
Petersen, GM1
Therneau, TM2
Roberts, LR2
Brusselaers, N2
Stefanini, B1
Tonnini, M1
Marseglia, M1
Tovoli, F2
Shen, X2
Kim, MH1
Park, SM1
Chang, J1
Hwang, IC1
Shi, T1
Gong, J1
Fujita, K1
Nishiyama, N1
Iwama, H1
Liu, S1
Nakahara, M1
Yoneyama, H1
Morishita, A1
Nonura, T1
Kobara, H1
Okano, K1
Suzuki, Y1
Masaki, T1
Liao, SF1
Koshiol, J1
Huang, YH2
Jackson, SS1
Chan, C1
Huang, C1
Liu, PC1
Chen, YJ1
Hsieh, RJ1
Huang, CP1
Lu, SN1
Chen, CJ1
Shen, CY1
Lee, MH1
Kamal, H1
Engstrand, L1
Lapumnuaypol, K3
Tiu, A3
Thongprayoon, C3
Wijarnpreecha, K3
Ungprasert, P3
Mao, MA3
Cheungpasitporn, W3
Lai, SW1
Du, MH1
Chu, KC1
Cheng, SW1
Bai, CH1
Hsu, YP1
Burr, NE1
Talboys, RJ1
Savva, S1
Clark, A1
Phillips, M1
Metcalfe, M1
Dennison, A1
Robinson, R1
Lewis, MP1
Rhodes, M1
Rushbrook, S1
Hart, AR1
Fujikawa, T1
Tanaka, A1
Sudsarn, P1
Boonmars, T1
Ruangjirachuporn, W1
Namwat, N2
Loilome, W2
Sriraj, P1
Aukkanimart, R1
Nadchanan, W1
Jiraporn, S1
Choi, J1
Ghoz, HM1
Peeraphatdit, T1
Baichoo, E1
Addissie, BD1
Olson, JE1
Chaiteerakij, R1
Bagante, F1
Gamblin, TC1
Pawlik, TM1
Brandi, G1
De Lorenzo, S1
Palloni, A1
Biasco, G1
Altaii, H1
Al-Kindi, SG1
Oliveira, GH1
Yaqoob, Z1
Romero-Marrero, C1
Puetkasichonpasutha, J1
Yongvanit, P1
Techasen, A1
Puapairoj, A1
Sripa, B1
Tassaneeyakul, W1
Khuntikeo, N1
Wongkham, S1

Reviews

2 reviews available for aspirin and Bile Duct Cancer

ArticleYear
A potential role for aspirin in the prevention and treatment of cholangiocarcinoma.
    International journal of cancer, 2021, 03-15, Volume: 148, Issue:6

    Topics: Animals; Aspirin; Bile Duct Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Humans; Incidence

2021
Effects of aspirin and non-steroidal anti-inflammatory drugs on the risk of cholangiocarcinoma: a meta-analysis.
    QJM : monthly journal of the Association of Physicians, 2019, Jun-01, Volume: 112, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile Duct Neoplasms; Cholangiocarcinoma; Humans; R

2019

Trials

1 trial available for aspirin and Bile Duct Cancer

ArticleYear
Acetylsalicylic acid for metal stent in malignant distal common bile duct obstruction: A randomized controlled trial.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2022, Volume: 21, Issue:5

    Topics: Aspirin; Bile Duct Neoplasms; Cholangiopancreatography, Endoscopic Retrograde; Cholestasis; Humans;

2022

Other Studies

18 other studies available for aspirin and Bile Duct Cancer

ArticleYear
Aspirin, Statins, Non-aspirin NSAIDs, Metformin, and the Risk of Biliary Cancer: A Swedish Population-Based Cohort Study.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2022, 04-01, Volume: 31, Issue:4

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile Duct Neoplasms; Bile Ducts, Intra

2022
Does aspirin use influence hepatocellular carcinoma and cholangiocarcinoma prognosis?
    Expert review of anticancer therapy, 2022, Volume: 22, Issue:9

    Topics: Aspirin; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Cholangiocarcinom

2022
Association Between Aspirin and Cholangiocarcinoma in a Large Asian Cohort.
    JAMA oncology, 2020, 12-01, Volume: 6, Issue:12

    Topics: Aged; Aspirin; Bile Duct Neoplasms; Case-Control Studies; Cholangiocarcinoma; Female; Humans; Incide

2020
Aspirin inhibits cholangiocarcinoma cell proliferation via cell cycle arrest in vitro and in vivo.
    International journal of oncology, 2021, Volume: 58, Issue:2

    Topics: Animals; Apoptosis; Aspirin; Bile Duct Neoplasms; Cell Line, Tumor; Cell Proliferation; Cholangiocar

2021
Postdiagnosis Aspirin Use Associated With Decreased Biliary Tract Cancer-Specific Mortality in a Large Nationwide Cohort.
    Hepatology (Baltimore, Md.), 2021, Volume: 74, Issue:4

    Topics: Aged; Aged, 80 and over; Ampulla of Vater; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile Du

2021
Association Between Proton Pump Inhibitor Use and Biliary Tract Cancer Risk: A Swedish Population-Based Cohort Study.
    Hepatology (Baltimore, Md.), 2021, Volume: 74, Issue:4

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile Duct Neoplasms; Bile

2021
Aspirin use and the risk of cholangiocarcinoma.
    QJM : monthly journal of the Association of Physicians, 2019, Aug-01, Volume: 112, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cho

2019
Reply to: 'Effects of aspirin and non-steroidal anti-inflammatory drugs on the risk of cholangiocarcinoma: a meta-analysis'.
    QJM : monthly journal of the Association of Physicians, 2019, Aug-01, Volume: 112, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cho

2019
Reply to: Effects of aspirin and non-steroidal anti-inflammatory drugs on the risk of cholangiocarcinoma: a meta-analysis.
    QJM : monthly journal of the Association of Physicians, 2019, Sep-01, Volume: 112, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cho

2019
Effects of aspirin and non-steroidal anti-inflammatory drugs on the risk of cholangiocarcinoma: a meta-analysis.
    QJM : monthly journal of the Association of Physicians, 2019, Sep-01, Volume: 112, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cho

2019
Aspirin may prevent cholangiocarcinoma: a case-control study from the United kingdom.
    Digestive diseases and sciences, 2014, Volume: 59, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile Duct Neoplasm

2014
Successful multidisciplinary treatment of hilar cholangiocarcinoma in a patient with complicated new-onset coronary artery disease.
    BMJ case reports, 2014, Apr-23, Volume: 2014

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Bile Duct Neoplasms; Bile Ducts, Intr

2014
Combination of Praziquantel and Aspirin Minimizes Liver Pathology of Hamster Opisthorchis viverrini Infection Associated Cholangiocarcinoma.
    Pathology oncology research : POR, 2016, Volume: 22, Issue:1

    Topics: Animals; Anthelmintics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile Duct Neoplasms; Bile

2016
Aspirin use and the risk of cholangiocarcinoma.
    Hepatology (Baltimore, Md.), 2016, Volume: 64, Issue:3

    Topics: Aged; Aspirin; Bile Duct Neoplasms; Case-Control Studies; Cholangiocarcinoma; Cohort Studies; Cycloo

2016
Cholangiocarcinoma risk factors and the potential role of aspirin.
    Hepatology (Baltimore, Md.), 2016, Volume: 64, Issue:3

    Topics: Aspirin; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Humans; Risk Factors

2016
Aspirin for cholangiocarcinoma prevention: New targets to shift the dogma from ascertained risk to possible prevention.
    Hepatology (Baltimore, Md.), 2017, Volume: 65, Issue:3

    Topics: Aspirin; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cardiovascular Diseases; Cholangiocarcinoma;

2017
Aspirin use and risk of cholangiocarcinoma: External validation with big data.
    Hepatology (Baltimore, Md.), 2017, Volume: 65, Issue:4

    Topics: Aspirin; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Humans

2017
Downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is associated with enhanced expression of matrix metalloproteinases and cholangiocarcinoma metastases.
    Journal of gastroenterology, 2011, Volume: 46, Issue:5

    Topics: Animals; Aspirin; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cholangiocarcinom

2011