aspirin and Bilateral Headache studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

Excerpt	Relevance	Reference
"The aim of this study is to investigate the effect of gradual dipyridamole titration and the incidence of dipyridamole-induced headache in patients with ischemic stroke or transient ischemic attack (TIA)."	9.51	Effects of Dose Titration on Dipyridamole-Induced Headache: A Randomized, Double-Blind Clinical Trial. ( Cha, JK; Chang, DI; Chang, JY; Chung, JW; Hong, KS; Jung, KH; Kang, MK; Kim, BK; Kim, HY; Lee, KY; Lee, SJ; Park, JM; Park, MS; Rha, JH; Shin, DI; Yoon, BW, 2022)
"We showed that slower than standard dose escalation of dipyridamole in combination therapy with acetylsalicylic acid does not reduce headaches as a side effect."	9.19	The effect of a slower than standard dose escalation scheme for dipyridamole on headaches in secondary prevention therapy of strokes: a randomized, open-label trial (DOSE). ( de Vogel, EM; de Vos-Koppelaar, NC; Dieleman, HG; Kerkhoff, H; Zock, E, 2014)
"Secondary pharmacological prevention of ischemic stroke or transient ischemic attack (TIA) is often provided with acetylsalicylic acid (ASA), dipyridamole (DP) or a combination of the two."	9.14	Dipyridamole-associated headache in stroke patients--interindividual differences? ( Lökk, J, 2009)
"Combination of low-dose aspirin and modified-release dipyridamole (ASA+MR-DP) provides a significantly increased benefit in stroke prevention over aspirin alone."	9.12	Dose titration to reduce dipyridamole-related headache. ( Chang, YJ; Lee, TH; Ryu, SJ, 2006)
"The authors assessed the prevalence of headaches following extended-release dipyridamole/aspirin combination (DAC), and the efficacy of acetaminophen in the treatment of these headaches."	9.11	Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination. ( Bigal, ME; Davidai, G; Gorelick, PB; Kolodner, KB; Lipton, RB; Schoebelock, M; Wilks, K, 2004)
"Headache is reported by about one third of patients using dipyridamole (DP) after stroke or TIA."	9.11	Dipyridamole and headache--a pilot study of initial dose titration. ( Husted, S; Lindgren, A; Staaf, G; Ziegler, B, 2004)
"The rapid decrease in the incidence of headaches over time implies that most patients quickly develop tolerance to dipyridamole-associated headaches."	9.09	Rapid development of tolerance to dipyridamole-associated headaches. ( Deichsel, G; Marshall, S; Theis, JG, 1999)
"Although the prophylactic intake of about 1 gram of aspirin reduced the headache incidence when exercising during acute high-altitude exposure, the incidence of headache was higher than previously shown for resting conditions."	9.09	Effects of aspirin during exercise on the incidence of high-altitude headache: a randomized, double-blind, placebo-controlled trial. ( Burtscher, M; Lämmle, T; Likar, R; Nachbauer, W; Philadelphy, M; Pühringer, R, 2001)
"A randomized, double-blind, placebo-controlled, multicenter study was conducted to ascertain the contribution of Fiorinal and codeine phosphate to the efficacy of Fiorinal with Codeine in relieving the pain, tension, and muscle stiffness associated with tension headache."	9.06	Assessment of Fiorinal with Codeine in the treatment of tension headache. ( Friedman, AP, 1986)
"The well-known difficulty in distinguishing the response to a combination headache medication and its individual components in the presence of a high placebo response was again demonstrated in a randomized, double-blind, placebo-controlled, multi-center trial comparing Fiorinal with Codeine and its Fiorinal and codeine phosphate components in relieving the pain, tension, and muscle contraction associated with tension headache."	9.06	Fiorinal with Codeine in the management of tension headache: impact of placebo response. ( Friedman, AP; Hwang, DS; Mietlowski, MJ, 1987)
"The contribution of the Fiorinal and codeine phosphate components to the effectiveness of the Fiorinal with Codeine combination in the treatment of tension headache symptoms was evaluated in a randomized, placebo-controlled, multicenter double-blind study."	9.06	Fiorinal with codeine in the treatment of tension headache--the contribution of components to the combination drug. ( Boyles, WF; Elkind, AH; Fillingim, J; Ford, RG; Friedman, AP; Gallagher, RM; Hobbs, D; Rapoport, A; Richards, BA; Sheftell, FD, 1988)
"The analgesic activity of 4-(p-fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone (fluproquazone) was investigated in three separate controlled studies including 131 outpatients with non-migrainous headache."	9.05	Fluproquazone: analgesic activity in outpatients with non-migrainous headache. ( von Graffenried, B; Wood, AJ, 1981)
"The tolerance of ketoprofen (2-(3-benzoylphenyl)-propionic acid) was studied in sixteen patients with rheumatoid arthritis during a treatment period up to seven months."	9.04	Long-term treatment with ketoprofen in rheumatoid arthritis. A clinical trial with special reference to side-effects. ( Peltola, P, 1976)
"According to international guidelines, aspirin should be considered as first-line therapy in primary headaches."	8.90	Pharmacokinetics and safety of a new aspirin formulation for the acute treatment of primary headaches. ( D'Alonzo, L; Lecchi, M; Martelletti, P; Negro, A, 2014)
"Combinations of analgesics with caffeine have been discussed as bearing a risk for headache chronicity."	7.81	Use of aspirin combinations with caffeine and increasing headache frequency: a prospective population-based study. ( Diener, HC; Geisel, MH; Jöckel, KH; Katsarava, Z; Moebus, S; Obermann, M; Özyurt Kugumcu, M; Schramm, SH; Yoon, MS, 2015)
"Our objective was to investigate the association between recurrent stroke risk and headache induced by extended-release dipyridamole (ER-DP) when administered alone or with low-dose aspirin (ASA+ER-DP)."	7.80	Dipyridamole-induced headache and lower recurrence risk in secondary prevention of ischaemic stroke: a post hoc analysis. ( Bath, PM; Cotton, D; Davidai, G; Diener, HC; Gorelick, P; Lipton, RB; Sacco, R, 2014)
"A considerable proportion of patients discontinue dipyridamole therapy because of headache."	7.75	Risk indicators for development of headache during dipyridamole treatment after cerebral ischaemia of arterial origin. ( Algra, A; Halkes, PH; Kappelle, LJ; Koudstaal, PJ; van Gijn, J, 2009)
"The purpose of this study was to determine safety and tolerability of clopidogrel in children with arterial ischemic stroke (AIS)."	7.73	The risks and safety of clopidogrel in pediatric arterial ischemic stroke. ( Allen, A; deVeber, G; Hune, S; MacGregor, D; Rafay, MF; Soman, T, 2006)
"The abuse of the combination drug containing butalbital 50 mg, aspirin 325 mg and caffeine 40 mg (or BAC), is commonly recognized by headache specialists as causing headaches."	7.68	A protocol for butalbital, aspirin and caffeine (BAC) detoxification in headache patients. ( Sands, GH, 1990)
"Recommendations for their use in treating headache should be based on individual patient suitability and on cost factors."	6.65	Comparison of 650 mg aspirin and 1,000 mg acetaminophen with each other, and with placebo in moderately severe headache. ( Fraim, CJ; Masel, BE; Peters, BH, 1983)
"Ketoprofen was preferred more often by the patients while the investigator found it acceptable as often as aspirin."	6.64	A double-blind cross-over evaluation of ketoprofen and aspirin in rheumatoid arthritis. ( Camerlain, M; Lussier, A; Menard, H; Myhal, D; Wehner, S, 1976)
" Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine."	6.55	Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017)
"The aim of this study is to investigate the effect of gradual dipyridamole titration and the incidence of dipyridamole-induced headache in patients with ischemic stroke or transient ischemic attack (TIA)."	5.51	Effects of Dose Titration on Dipyridamole-Induced Headache: A Randomized, Double-Blind Clinical Trial. ( Cha, JK; Chang, DI; Chang, JY; Chung, JW; Hong, KS; Jung, KH; Kang, MK; Kim, BK; Kim, HY; Lee, KY; Lee, SJ; Park, JM; Park, MS; Rha, JH; Shin, DI; Yoon, BW, 2022)
" This clinical report suggests that chronic use of headache powders can also be a factor leading to tooth erosion."	5.31	Dental erosion and aspirin headache powders: a clinical report. ( McCracken, M; O'Neal, SJ, 2000)
"We showed that slower than standard dose escalation of dipyridamole in combination therapy with acetylsalicylic acid does not reduce headaches as a side effect."	5.19	The effect of a slower than standard dose escalation scheme for dipyridamole on headaches in secondary prevention therapy of strokes: a randomized, open-label trial (DOSE). ( de Vogel, EM; de Vos-Koppelaar, NC; Dieleman, HG; Kerkhoff, H; Zock, E, 2014)
"The Thomapyrin Study showed the significant superiority of the fixed combination of acetylsalicylic acid + paracetamol + caffeine over the combination without caffeine, the single preparations, and placebo in the treatment of headache."	5.16	Pain measurement: Visual Analogue Scale (VAS) and Verbal Rating Scale (VRS) in clinical trials with OTC analgesics in headache. ( Aicher, B; Diener, HC; Peil, B; Peil, H, 2012)
"Secondary pharmacological prevention of ischemic stroke or transient ischemic attack (TIA) is often provided with acetylsalicylic acid (ASA), dipyridamole (DP) or a combination of the two."	5.14	Dipyridamole-associated headache in stroke patients--interindividual differences? ( Lökk, J, 2009)
"Combination of low-dose aspirin and modified-release dipyridamole (ASA+MR-DP) provides a significantly increased benefit in stroke prevention over aspirin alone."	5.12	Dose titration to reduce dipyridamole-related headache. ( Chang, YJ; Lee, TH; Ryu, SJ, 2006)
"Headache is reported by about one third of patients using dipyridamole (DP) after stroke or TIA."	5.11	Dipyridamole and headache--a pilot study of initial dose titration. ( Husted, S; Lindgren, A; Staaf, G; Ziegler, B, 2004)
"The authors assessed the prevalence of headaches following extended-release dipyridamole/aspirin combination (DAC), and the efficacy of acetaminophen in the treatment of these headaches."	5.11	Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination. ( Bigal, ME; Davidai, G; Gorelick, PB; Kolodner, KB; Lipton, RB; Schoebelock, M; Wilks, K, 2004)
"Although the prophylactic intake of about 1 gram of aspirin reduced the headache incidence when exercising during acute high-altitude exposure, the incidence of headache was higher than previously shown for resting conditions."	5.09	Effects of aspirin during exercise on the incidence of high-altitude headache: a randomized, double-blind, placebo-controlled trial. ( Burtscher, M; Lämmle, T; Likar, R; Nachbauer, W; Philadelphy, M; Pühringer, R, 2001)
"The rapid decrease in the incidence of headaches over time implies that most patients quickly develop tolerance to dipyridamole-associated headaches."	5.09	Rapid development of tolerance to dipyridamole-associated headaches. ( Deichsel, G; Marshall, S; Theis, JG, 1999)
"The well-known difficulty in distinguishing the response to a combination headache medication and its individual components in the presence of a high placebo response was again demonstrated in a randomized, double-blind, placebo-controlled, multi-center trial comparing Fiorinal with Codeine and its Fiorinal and codeine phosphate components in relieving the pain, tension, and muscle contraction associated with tension headache."	5.06	Fiorinal with Codeine in the management of tension headache: impact of placebo response. ( Friedman, AP; Hwang, DS; Mietlowski, MJ, 1987)
"A randomized, double-blind, placebo-controlled, multicenter study was conducted to ascertain the contribution of Fiorinal and codeine phosphate to the efficacy of Fiorinal with Codeine in relieving the pain, tension, and muscle stiffness associated with tension headache."	5.06	Assessment of Fiorinal with Codeine in the treatment of tension headache. ( Friedman, AP, 1986)
"The contribution of the Fiorinal and codeine phosphate components to the effectiveness of the Fiorinal with Codeine combination in the treatment of tension headache symptoms was evaluated in a randomized, placebo-controlled, multicenter double-blind study."	5.06	Fiorinal with codeine in the treatment of tension headache--the contribution of components to the combination drug. ( Boyles, WF; Elkind, AH; Fillingim, J; Ford, RG; Friedman, AP; Gallagher, RM; Hobbs, D; Rapoport, A; Richards, BA; Sheftell, FD, 1988)
"The analgesic activity of 4-(p-fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone (fluproquazone) was investigated in three separate controlled studies including 131 outpatients with non-migrainous headache."	5.05	Fluproquazone: analgesic activity in outpatients with non-migrainous headache. ( von Graffenried, B; Wood, AJ, 1981)
" For hemicrania we used cinnarizine, cyproheptadine, clonidine, histamine, pizotifene and reserpine; for cluster headache, cinnarizine, cyproheptadine, clonidine, histamine and reserpine; for tension headache, cyproheptadine; for psychogenic headache, allylpropylmalonylurea."	5.04	[Therapeutic possibilities in idiopathic headaches. Analysis of 1000 cases (author's transl)]. ( Agostoni, A; Brandi, G; Cottino, A; Gai, V; Gastaldi, L; Lisino, F; Nattero, G, 1975)
"The tolerance of ketoprofen (2-(3-benzoylphenyl)-propionic acid) was studied in sixteen patients with rheumatoid arthritis during a treatment period up to seven months."	5.04	Long-term treatment with ketoprofen in rheumatoid arthritis. A clinical trial with special reference to side-effects. ( Peltola, P, 1976)
"A double-blind, cross-over trial was made of three analgesic preparations--paracetamol, paracetamol with caffeine (Finimal) and aspirin in the relief of postoperative pain in 72 orthopedic inpatients and in 144 ambulatory outpatients suffering form common idiopathic headache."	5.04	A double-blind comparative evaluation of aspirin, paracetamol and paracetamol + caffeine (finimal) for their analgesic effectiveness. ( Lawczyński, L; Olszewska, M; Samochowiec, L; Szwed, G; Wójcicki, J, 1977)
"According to international guidelines, aspirin should be considered as first-line therapy in primary headaches."	4.90	Pharmacokinetics and safety of a new aspirin formulation for the acute treatment of primary headaches. ( D'Alonzo, L; Lecchi, M; Martelletti, P; Negro, A, 2014)
" In this study, we also evaluate three "budget" over-the-counter headache medications (subsequently labeled as brands A, B, and C) for agglomeration of the three APIs in the formulation: Acetaminophen, aspirin, and caffeine."	4.02	Diagnosis of Agglomeration and Crystallinity of Active Pharmaceutical Ingredients in Over the Counter Headache Medication by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging. ( Dimmitt, NH; Green, AM; Hubbard, ND; Khan, SM; McVey, PA; Taulbee-Cotton, BV; Van Meter, MI; Webster, GK, 2021)
" This man was promptly treated with aspirin 300 mg one time per day, as per the stroke pathway."	3.91	Bilateral paramedian pontine infarcts: a rare cause of bilateral horizontal gaze palsy. ( Bhandari, M; Chernov, D; Hassan, F; Karavassilis, ME, 2019)
"Combinations of analgesics with caffeine have been discussed as bearing a risk for headache chronicity."	3.81	Use of aspirin combinations with caffeine and increasing headache frequency: a prospective population-based study. ( Diener, HC; Geisel, MH; Jöckel, KH; Katsarava, Z; Moebus, S; Obermann, M; Özyurt Kugumcu, M; Schramm, SH; Yoon, MS, 2015)
"Our objective was to investigate the association between recurrent stroke risk and headache induced by extended-release dipyridamole (ER-DP) when administered alone or with low-dose aspirin (ASA+ER-DP)."	3.80	Dipyridamole-induced headache and lower recurrence risk in secondary prevention of ischaemic stroke: a post hoc analysis. ( Bath, PM; Cotton, D; Davidai, G; Diener, HC; Gorelick, P; Lipton, RB; Sacco, R, 2014)
"A considerable proportion of patients discontinue dipyridamole therapy because of headache."	3.75	Risk indicators for development of headache during dipyridamole treatment after cerebral ischaemia of arterial origin. ( Algra, A; Halkes, PH; Kappelle, LJ; Koudstaal, PJ; van Gijn, J, 2009)
"In the Prevention Regimen for Effectively Avoiding Second Strokes (PROFESS) trial, the combination of acetylsalicylic acid (50 mg) and extended-release dipyridamole (400 mg) (ASA+Dip) was compared with clopidogrel (75 mg) in patients with a recent transient ischaemic attack (TIA) or minor disabling stroke."	3.74	[Inhibition of platelet aggregation and angiotensin II-receptor blockade following TIA; the unexpected results of the Prevention Regimen For Effectively Avoiding Second Strokes (PROFESS) trial]. ( Kappelle, LJ, 2008)
"The purpose of this study was to determine safety and tolerability of clopidogrel in children with arterial ischemic stroke (AIS)."	3.73	The risks and safety of clopidogrel in pediatric arterial ischemic stroke. ( Allen, A; deVeber, G; Hune, S; MacGregor, D; Rafay, MF; Soman, T, 2006)
"The Fernand Widal syndrome combines a nasal polyposis, an asthma and aspirin sensitivity."	3.70	[Fernand Widal syndrome: apropos of 2 cases]. ( Ba, O; Cissokho, S; Dia, Y; Diatta, A; Diouf, R; Hane, AA; Kandji, M; Ndiaye, M; Ndiaye, S; Ndir, M; Niang, A, 1999)
" She developed post-dural puncture headache (PDPH) on the third postpartum day which was managed by palliative measures: bed rest (patient's position of choice), increased hydration (water: 3 litres po per day), lysine acetyl salicylate (5."	3.70	Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour. ( Agustí, M; Carrero, EJ; Fábregas, N; Fernández, C; Valldeoriola, F, 1998)
" Further investigation revealed that her mother had taken aspirin throughout pregnancy."	3.68	Toxic reaction to salicylate in a newborn infant: similarities to neonatal sepsis. ( Bond, GR; Buck, ML; Grebe, TA, 1993)
"The abuse of the combination drug containing butalbital 50 mg, aspirin 325 mg and caffeine 40 mg (or BAC), is commonly recognized by headache specialists as causing headaches."	3.68	A protocol for butalbital, aspirin and caffeine (BAC) detoxification in headache patients. ( Sands, GH, 1990)
"Two commonly taken over-the-counter analgesics, aspirin and acetaminophen, were compared for: effect on total menstrual loss, effect on total days of menstruation, and effect in reduction of pain due to headaches and/or menstrual cramps."	3.67	Do aspirin and acetaminophen affect total menstrual loss? ( Agna, MA; Pendergrass, PB; Ream, LJ; Scott, JN, 1984)
"Aspirin and acetaminophen are, as a rule, effective and well-tolerated compounds for use in mild pain of various etiologies."	3.66	Drugs for pain in the elderly. ( Pfeiffer, RF, 1982)
"Reductions in thrombus area under high shear conditions correlated with reductions in platelet count (r²=0."	2.79	Antithrombotic properties of rafigrelide: a phase 1, open-label, non-randomised, single-sequence, crossover study. ( Balasubramaniam, K; Dragone, J; Grose-Hodge, R; Martin, P; Preston, P; Troy, S; Viswanathan, G; Zaman, AG, 2014)
"Side effects, such as arrhythmia, angina pectoris, and nervous headache, were observed in the celecoxib 400 mg/d group."	2.72	[Clinical management of adenomatous polyposis in patients with hereditary non-polyposis colorectal cancer and familial adenomatous polyposis]. ( Geng, HG; Li, SR; Sheng, JQ; Su, H; Yan, W; Yang, XY; Yu, DL; Zhang, YH, 2006)
"Dipyridamole was associated with a slight increase in headache, which resolved in most patients if therapy was continued."	2.69	Secondary stroke prevention with low-dose aspirin, sustained release dipyridamole alone and in combination. ESPS Investigators. European Stroke Prevention Study. ( Forbes, CD, 1998)
"Recommendations for their use in treating headache should be based on individual patient suitability and on cost factors."	2.65	Comparison of 650 mg aspirin and 1,000 mg acetaminophen with each other, and with placebo in moderately severe headache. ( Fraim, CJ; Masel, BE; Peters, BH, 1983)
"Ketoprofen was preferred more often by the patients while the investigator found it acceptable as often as aspirin."	2.64	A double-blind cross-over evaluation of ketoprofen and aspirin in rheumatoid arthritis. ( Camerlain, M; Lussier, A; Menard, H; Myhal, D; Wehner, S, 1976)
" Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine."	2.55	Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017)
"Bleeding is potentially the most significant antiplatelet-associated side effect."	2.47	Review and management of side effects associated with antiplatelet therapy for prevention of recurrent cerebrovascular events. ( Guthrie, R, 2011)
"In comparison with transient ischemic attacks in patients with vascular risk factors, the usual neurologic presentation of ET consists of brief attacks of sudden cerebral or visual dysfunction, which can be either well localized or diffuse and entirely nonspecific."	2.40	Neurologic and visual symptoms in essential thrombocythemia: efficacy of low-dose aspirin. ( Koudstaal, A; Koudstaal, PJ, 1997)
"The various forms of ASA used to treat headache are discussed and the controlled studies conducted to evaluate ASA's efficacy in headache treatment are summarized."	2.40	Acetylsalicylic acid in the treatment of headache. ( Diener, HC; Katsarava, Z; Limmroth, V, 1999)
"Prochlorperazine injection has been upgraded to a highly recommended level because of the rich clinical experience for this treatment."	1.72	2022 Taiwan Guidelines for Acute Treatment of Migraine. ( Lau, CI; Wang, YF, 2022)
"Cerebral vasospasm was more often only mild and rates of cerebral infarctions were lower in the OTA group but not on a significant level."	1.51	Pain medication at ictus of subarachnoid hemorrhage-the influence of one-time acetylsalicylic acid usage on bleeding pattern, treatment course, and outcome: a matched pair analysis. ( Brawanski, N; Bruder, M; Kashefiolasl, S; Keil, F; Konczalla, J; Seifert, V; Won, SY, 2019)
"Giant cell arteritis is a common cause of headache in patients aged more than 50 years."	1.40	A stroke of bad luck. ( Joshi, Y; Nagasayi, S; White, S, 2014)
" The reference dose of Diclofenac used in all randomized controlled trials is 150 mg/die; this controlled release dosage allows to decrease the number of daily administrations, ensuring a better patient compliance, especially if elderly and/or in polytherapy."	1.40	[Diclofenac: update on tolerableness and spinal anti-inflammatory action]. ( Sandri, A, 2014)
"Unilateral vertebral artery dissection has been described in fewer than 40% of cases of RCVS."	1.39	Reversible cerebral vasoconstriction syndrome and bilateral vertebral artery dissection presenting in a patient after cesarean section. ( Do, HM; Mitchell, LA; Santarelli, JG; Singh, IP, 2013)
"Treatment of intracranial fusiform aneurysms is complex and controversial, and is associated with high morbidity and mortality rates."	1.39	Using Leo Plus stent as flow diverter and endoluminal remodeling in endovascular treatment of intracranial fusiform aneurysms. ( Ageitos, M; Arias-Rivas, S; Blanco, M; Castiñeira-Mourenza, JA; Masso, A; Pumar, JM; Rodríguez-Yáñez, M; Vazquez-Herrero, F, 2013)
"Previously, all reports of intracranial hemorrhages in MDMA abusers were associated with coingestion of other sympathomimetic drugs, or with pre-existing cerebrovascular lesions."	1.38	3 cases of primary intracranial hemorrhage associated with "Molly", a purified form of 3,4-methylenedioxymethamphetamine (MDMA). ( Benveniste, RJ; Ferraro, N; Kahn, DE, 2012)
"This study identified underdiagnosis of migraine, low use of migraine prophylaxis and triptans, and high prevalence of medication overuse among subjects seeking self-medication for regular headache."	1.38	[Self-medication of regular headache: a community pharmacy-based survey in Belgium]. ( Boussery, K; Christiaens, T; De Bolle, L; Evrard, B; Mehuys, E; Paemeleire, K; Philippe, G; Piette, M; Prévôt, ML; Remon, JP; Van Bortel, L; Van Hees, T; Van Tongelen, I, 2012)
"Postpartum headache is quite common and often related to potentially ominous cerebrovascular accidents."	1.37	Postpartum headache due to spontaneous cervical artery dissection. ( Baldacci, F; Berti, C; Bonuccelli, U; Borelli, P; Logi, C; Lucetti, C; Nuti, A; Orlandi, G, 2011)
"Moyamoya disease is a progressive, unilateral, or bilateral carotid artery stenosis of unknown etiology."	1.35	Moyamoya disease in an 8-year-old boy presenting with weakness. ( Johnson, LH; Tenney, J, 2009)
"Aspirin was used by 7."	1.33	Use and misuse of aspirin in rural Ethiopia. ( Aref-Adib, G; Britton, J; Davey, G; Duncan, P; Venn, A, 2006)
"Moreover, chronic renal failure may occur due to a chronic interstitial nephritis or an analgesic nephropathy that is characterized by capillary sclerosis and papillary necrosis in addition to chronic interstitial nephritis."	1.33	[Chronic interstitial nephritis in an 18-year-old due to intake of a compound analgesic]. ( Janssen, U; Jochum, E, 2006)
"We report 6 cases of Kawasaki disease (KD) diagnosed over a period of one year and review of all the cases reported from India."	1.33	Kawasaki disease: are we missing the diagnosis? ( Anirudh, D; Goel, H; Kabra, SK; Lodha, R; Sridhar, MR, 2005)
" This clinical report suggests that chronic use of headache powders can also be a factor leading to tooth erosion."	1.31	Dental erosion and aspirin headache powders: a clinical report. ( McCracken, M; O'Neal, SJ, 2000)
"The long-term effects of substance abuse are contingent on the compounds that are used."	1.28	Drug abuse and headache. ( Elkind, AH, 1991)
" It is proposed in general that pharmacokinetic parameters may vary in accord with the physiologic circadian phase at the time of drug challenge."	1.26	Chronopharmacokinetics of ethanol. III. Variation in rate of ethanolemia decay in human subjects. ( Pauly, JE; Scheving, LE; Sturtevant, FM; Sturtevant, RP, 1978)
"Aspirin prescriptions were consistent over the entire study period among inpatients, but preadmission use decreased substantially."	1.26	Acetaminophen and aspirin. Prescription, use, and accidental ingestion among children. ( Lovejoy, FH; Mitchell, AA; Shapiro, S; Slone, D, 1982)
" If preterm labour was stopped, the dosage had been reduced."	1.26	[Clinical study of the labour inhibiting effects an side effects of acetylsalicylic acid (ASA) (author's transl)]. ( Berg, R; Bolte, A; Wolff, F, 1981)

Research

Studies (203)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Duration of Headache Free Period at 7 Days

Number of Participants With Development of Hypertensive Disease of Pregnancy Within 28 Days

Number of Participants With Development of Hypertensive Disease of Pregnancy Within 7 Days

Number of Participants With Injection Site Complication (Infection, Hematoma, and Ecchymosis)

Number of Participants With Need for Admission for Treatment of Headache

Number of Participants With Need for Crossover Treatment

Number of Participants With Need for Neurology Consult

Number of Participants With Need for Representation for Treatment of Headache With 28 Days

Timeframe	Studies, this research(%)	All Research%
pre-1990	89 (43.84)	18.7374
1990's	29 (14.29)	18.2507
2000's	36 (17.73)	29.6817
2010's	42 (20.69)	24.3611
2020's	7 (3.45)	2.80

Authors	Studies
Kazama, I	1
Senzaki, M	1
Kang, MK	1
Cha, JK	1
Chang, DI	1
Kim, HY	1
Chung, JW	1
Jung, KH	1
Hong, KS	1
Chang, JY	1
Rha, JH	1
Park, JM	1
Kim, BK	1
Lee, SJ	1
Park, MS	1
Lee, KY	1
Shin, DI	1
Yoon, BW	1
Lau, CI	1
Wang, YF	1
Chernov, D	1
Karavassilis, ME	1
Hassan, F	1
Bhandari, M	1
Eisenmenger, LB	1
Rivera-Rivera, LA	1
Johnson, KM	1
Drolet, BA	1
Li, J	1
Chen, Y	1
Liu, J	1
Mai, X	1
Jing, S	1
McGrath, E	1
Jadcherla, Y	1
Held, J	1
Ang, JY	1
Van Meter, MI	1
Khan, SM	1
Taulbee-Cotton, BV	1
Dimmitt, NH	1
Hubbard, ND	1
Green, AM	1
Webster, GK	1
McVey, PA	1
Hewett, KM	1
Lorenzetti, B	1
Jackson, BF	1
Lipton, RB	4
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Acute Headache Treatment in Pregnancy: Improvement in Pain Scores With Occipital Nerve Block vs PO Acetaminophen With Caffeine A Randomized Controlled Trial[NCT03951649]	Phase 4	62 participants (Actual)	Interventional	2020-02-10	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	days (Median)
Occipital Nerve Block	6
Oral Acetaminophen/Caffeine Group	1

Intervention	Participants (Count of Participants)
Occipital Nerve Block	9
Oral Acetaminophen/Caffeine Group	4

Intervention	Participants (Count of Participants)
Occipital Nerve Block	7
Oral Acetaminophen/Caffeine Group	2

Intervention	Participants (Count of Participants)
Occipital Nerve Block	0
Oral Acetaminophen/Caffeine Group	2

Intervention	Participants (Count of Participants)
Occipital Nerve Block	0
Oral Acetaminophen/Caffeine Group	0

Intervention	Participants (Count of Participants)
Occipital Nerve Block	9
Oral Acetaminophen/Caffeine Group	14

Intervention	Participants (Count of Participants)
Occipital Nerve Block	4
Oral Acetaminophen/Caffeine Group	2

Emergency department for treatment of headache since treatment asked at 28 day follow up (NCT03951649)
Timeframe: 28 days

Number of Participants With Need for Second Line Treatment

Number of Participants With Response to Occipital Nerve Block in Pregnancy

Intervention	Participants (Count of Participants)
Occipital Nerve Block	5
Oral Acetaminophen/Caffeine Group	1

Intervention	Participants (Count of Participants)
Occipital Nerve Block	5
Oral Acetaminophen/Caffeine Group	5

Based on guidelines from the International Headache Society the primary outcome is the portion of women who experience resolution of headache or improvement of headache to mild range (VRS ≤ 3) at 2 hours following treatment with Occipital nerve block as compared to acetaminophen/caffeine cocktail. (NCT03951649)
Timeframe: 60-300 min

Response to Cross Over Treatment at 60 Min

Intervention	Participants (Count of Participants)
Occipital Nerve Block	20
Oral Acetaminophen/Caffeine Group	16

"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 60 min

Response to Second Line Treatment at 60 Min

Intervention	score on a scale (Median)
Occipital Nerve Block	6
Oral Acetaminophen/Caffeine Group	3

Response to Treatment Within 2 Hours

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Headache as a model for testing mild analgesics. Research and clinical studies in headache, 1978, Volume: 6 Topics: Adult; Aminopyrine; Analgesics; Antipyrine; Aspirin; Barbiturates; Caffeine; Clinical Trials as Topi	1978
A new (?) Clinical headache entity "chronic paroxysmal hemicrania" 2. Acta neurologica Scandinavica, 1976, Volume: 54, Issue:2 Topics: Affective Symptoms; Aspirin; Cerebrovascular Circulation; Chronic Disease; Clinical Trials as Topic;	1976
A double-blind cross-over evaluation of ketoprofen and aspirin in rheumatoid arthritis. Scandinavian journal of rheumatology. Supplement, 1976, Volume: 1976, Issue:0 Topics: Adult; Aged; Analgesics; Arthritis, Rheumatoid; Aspirin; Benzophenones; Clinical Trials as Topic; Dr	1976
[Therapeutic possibilities in idiopathic headaches. Analysis of 1000 cases (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1975, Sep-19, Volume: 117, Issue:38 Topics: Aspirin; Caffeine; Cinnarizine; Clinical Trials as Topic; Clonidine; Cyproheptadine; Drug Therapy, C	1975
Long-term treatment with ketoprofen in rheumatoid arthritis. A clinical trial with special reference to side-effects. Scandinavian journal of rheumatology. Supplement, 1976, Volume: 1976, Issue:0 Topics: Analgesics; Arthritis, Rheumatoid; Aspirin; Benzophenones; Clinical Trials as Topic; Diarrhea; Drug	1976
Acetylsalicylic acid activates antinociceptive brain-stem reflex activity in headache patients and in healthy subjects. Pain, 1992, Volume: 48, Issue:2 Topics: Adult; Analysis of Variance; Aspirin; Brain Stem; Electromyography; Female; Headache; Humans; Male;	1992
Headache pain model for assessing and comparing the efficacy of over-the-counter analgesic agents. Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:3 Topics: Acetaminophen; Adult; Analgesics; Aspirin; Caffeine; Double-Blind Method; Drug Combinations; Drug Ev	1991
Comparison of long-term safety of ketorolac tromethamine and aspirin in the treatment of chronic pain. Pharmacotherapy, 1990, Volume: 10, Issue:6 ( Pt 2) Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; D	1990
Analgesic use and chronic renal disease. The New England journal of medicine, 1989, May-11, Volume: 320, Issue:19 Topics: Acetaminophen; Adult; Aged; Analgesics; Arthritis; Aspirin; Chronic Disease; Dose-Response Relations	1989
Fiorinal with codeine in the treatment of tension headache--the contribution of components to the combination drug. Clinical therapeutics, 1988, Volume: 10, Issue:3 Topics: Adolescent; Adult; Aspirin; Barbiturates; Caffeine; Codeine; Double-Blind Method; Drug Combinations;	1988
Flurbiprofen versus ASA in influenza symptomatology: a double-blind study. International journal of clinical pharmacology research, 1986, Volume: 6, Issue:6 Topics: Adult; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Flurbiprofen; Headache; Human	1986
Fiorinal with Codeine in the management of tension headache: impact of placebo response. Clinical therapeutics, 1987, Volume: 9, Issue:2 Topics: Adult; Anxiety; Aspirin; Barbiturates; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Met	1987
Effervescent ASA versus solid ASA in the treatment of tension headache. A double-blind, placebo controlled study. Headache, 1987, Volume: 27, Issue:2 Topics: Adolescent; Adult; Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Headache; H	1987
Assessment of Fiorinal with Codeine in the treatment of tension headache. Clinical therapeutics, 1986, Volume: 8, Issue:6 Topics: Aspirin; Barbiturates; Caffeine; Codeine; Drug Combinations; Emotions; Headache; Humans; Muscle Cont	1986
Effect of small doses of aspirin and acetaminophen on total menstrual loss and pain of cramps and headache. Gynecologic and obstetric investigation, 1985, Volume: 19, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Analysis of Variance; Aspirin; Clinical Trials as Topic; Double-Bl	1985
Evaluation of indomethacin by a controlled, cross-over technique in 30 patients with ankylosing spondylitis. Canadian Medical Association journal, 1967, Jun-03, Volume: 96, Issue:22 Topics: Alkaline Phosphatase; Anemia, Hypochromic; Aspartate Aminotransferases; Aspirin; Central Nervous Sys	1967
Double-blind study of the analgesic effect of ethoheptazine-aspirin. Current therapeutic research, clinical and experimental, 1974, Volume: 16, Issue:7 Topics: Adolescent; Adult; Aged; Analysis of Variance; Aspirin; Azepines; Clinical Trials as Topic; Depressi	1974
[First results of the clinical use of injectable lysine acetylsalicylate]. Minerva medica, 1972, Nov-21, Volume: 63, Issue:83 Topics: Adult; Aged; Analgesics; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Combinations	1972
Analysis of symptoms of patients with headaches and their response to treatment with ergot derivatives. The Quarterly journal of medicine, 1968, Volume: 37, Issue:146 Topics: Adolescent; Adult; Aged; Aspirin; Clinical Trials as Topic; Ergonovine; Ergotamine; Female; Headache	1968
Experimental observations on flufenamic, mefenamic, and meclofenamic acids. IV. Toleration by normal human subjects. Annals of physical medicine, 1966, Volume: Suppl Topics: Adult; Anti-Inflammatory Agents; Aspirin; Biphenyl Compounds; Blood Coagulation; Blood Urea Nitrogen	1966
Propoxyphene hydrochloride. A critical review. JAMA, 1970, Aug-10, Volume: 213, Issue:6 Topics: Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Female; Headac	1970
Controlled and uncontrolled studies on "Fiorinal-PA" for symptomatic relief in tension headache. The Medical journal of Australia, 1970, Jul-25, Volume: 2, Issue:4 Topics: Acetaminophen; Aspirin; Barbiturates; Caffeine; Clinical Trials as Topic; Drug Synergism; Headache;	1970

Article	Year
Does immunosuppressive property of non-steroidal anti-inflammatory drugs (NSAIDs) reduce COVID-19 vaccine-induced systemic side effects? Drug discoveries & therapeutics, 2021, Nov-21, Volume: 15, Issue:5 Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; COVID-19 Vaccines; Fati	2021
2022 Taiwan Guidelines for Acute Treatment of Migraine. Acta neurologica Taiwanica, 2022, Jun-30, Volume: 31(2) Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Aspirin; Caffeine; Calcitonin G	2022
Bilateral paramedian pontine infarcts: a rare cause of bilateral horizontal gaze palsy. BMJ case reports, 2019, Oct-31, Volume: 12, Issue:10 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atrial Flutter; Brain; Cerebral Infarction;	2019
Utilisation of advanced MRI techniques to understand neurovascular complications of PHACE syndrome: a case of arterial stenosis and dissection. BMJ case reports, 2020, Sep-14, Volume: 13, Issue:9 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aortic Coarctation; Aspirin; Child; Eye Abnormalities; Fema	2020
Is it coincidental or correlative between reversible splenial lesion syndrome and atrial septal defect?: A case report. Medicine, 2020, Oct-23, Volume: 99, Issue:43 Topics: Administration, Oral; Antihypertensive Agents; Aspirin; Brain Diseases; Corpus Callosum; Diffusion M	2020
A Real Pain in the Neck. Clinical pediatrics, 2021, Volume: 60, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atlanto-Axial Joint; Cellulitis; Cervical Vertebra	2021
Diagnosis of Agglomeration and Crystallinity of Active Pharmaceutical Ingredients in Over the Counter Headache Medication by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging. Molecules (Basel, Switzerland), 2021, Jan-25, Volume: 26, Issue:3 Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Caffeine; Headache; Lasers; Nonprescription Drugs;	2021
Ataxia and Headache in a Child: A Case of Acute Cerebellar Infarction. Pediatric emergency care, 2017, Volume: 33, Issue:8 Topics: Acute Disease; Anticoagulants; Aspirin; Cerebellar Ataxia; Cerebellum; Cerebral Infarction; Child, P	2017
Physicians Addicted to Prescribing Aspirin-a Disorder Of Cardiologists (PAPA-DOC) Syndrome: The Headache of Nonevidence-Based Medicine for Ischemic Heart Disease? JACC. Heart failure, 2018, Volume: 6, Issue:2 Topics: Aspirin; Atrial Fibrillation; Cardiologists; Headache; Heart Failure; Humans; Myocardial Ischemia; P	2018
[«Man-in-the-barrel» syndrome: atypical manifestation of giant cell arteritis]. Revista de neurologia, 2018, Jun-01, Volume: 66, Issue:11 Topics: Aged; Aorta; Aspirin; Brachial Plexus Neuropathies; Craniofacial Fibrous Dysplasia; Electromyography	2018
Pain medication at ictus of subarachnoid hemorrhage-the influence of one-time acetylsalicylic acid usage on bleeding pattern, treatment course, and outcome: a matched pair analysis. Neurosurgical review, 2019, Volume: 42, Issue:2 Topics: Adult; Aged; Anticoagulants; Aspirin; Cerebral Infarction; Female; Fibrinolytic Agents; Headache; Ho	2019
Unusual right internal carotid artery supraclinoid segment fenestration associated with multiple aneurysms treated with flow diversion and coiling. BMJ case reports, 2018, Sep-10, Volume: 2018 Topics: Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Clopidogrel; Endovascular Procedures; Fe	2018
Early detection of vertebral artery dissection. BMJ case reports, 2018, Nov-28, Volume: 11, Issue:1 Topics: Adult; Aftercare; Aspirin; Computed Tomography Angiography; Diagnosis, Differential; Early Diagnosis	2018
Significant infrarenal aortic stenosis in pregnancy: a case report. Journal of medical case reports, 2019, May-01, Volume: 13, Issue:1 Topics: Adult; Aortic Valve Stenosis; Aspirin; Calcium; Calcium-Regulating Hormones and Agents; Cesarean Sec	2019
57-Year-Old Man With Vertigo. Mayo Clinic proceedings, 2019, Volume: 94, Issue:6 Topics: Aspirin; Cerebellum; Cerebral Infarction; Headache; Humans; Magnetic Resonance Angiography; Male; Mi	2019
Posterior reversible encephalopathy syndrome, preeclampsia or stroke? A diagnostic dilemma. BMJ case reports, 2019, Jul-27, Volume: 12, Issue:7 Topics: Abdominal Pain; Adrenergic beta-Antagonists; Aspirin; Diagnosis, Differential; Factor V; Female; Hea	2019
Using Leo Plus stent as flow diverter and endoluminal remodeling in endovascular treatment of intracranial fusiform aneurysms. Journal of neurointerventional surgery, 2013, Volume: 5 Suppl 3 Topics: Adult; Aged; Anesthesia, General; Aneurysm; Angiography, Digital Subtraction; Aspirin; Blepharoptosi	2013
Problem based review: The patient with a pyrexia of unknown origin. Acute medicine, 2013, Volume: 12, Issue:2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Infective Agents; Anti-Inflammatory Agents; Aorta; Aor	2013
Sudden bilateral vision loss and brain infarction following cosmetic hyaluronic acid injection. JAMA ophthalmology, 2013, Volume: 131, Issue:9 Topics: Acetazolamide; Antihypertensive Agents; Aspirin; Blindness; Cerebral Infarction; Cosmetic Techniques	2013
Dipyridamole-induced headache and lower recurrence risk in secondary prevention of ischaemic stroke: a post hoc analysis. European journal of neurology, 2014, Volume: 21, Issue:10 Topics: Aged; Aspirin; Brain Ischemia; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination;	2014
[Diclofenac: update on tolerableness and spinal anti-inflammatory action]. Minerva medica, 2014, Volume: 105, Issue:4 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood-Brain Barrier; Car	2014
A stroke of bad luck. Clinical medicine (London, England), 2014, Volume: 14, Issue:6 Topics: Aspirin; Female; Giant Cell Arteritis; Headache; Humans; Middle Aged; Steroids; Stroke	2014
Use of aspirin combinations with caffeine and increasing headache frequency: a prospective population-based study. Pain, 2015, Volume: 156, Issue:9 Topics: Adolescent; Adult; Aged; Aspirin; Caffeine; Cohort Studies; Community Health Planning; Drug Combinat	2015
[Cerebral venous thrombosis revealing Behçet disease in a child]. The Pan African medical journal, 2015, Volume: 20 Topics: Aspirin; Azathioprine; Behcet Syndrome; Child; Drug Therapy, Combination; Headache; Humans; Immunosu	2015
Bifrontal headache · blurred vision · vomiting · Dx? The Journal of family practice, 2015, Volume: 64, Issue:6 Topics: Aspirin; Clopidogrel; Diagnosis, Differential; Drug Therapy, Combination; Female; Headache; Humans;	2015
[Acute unilateral arteritic anterior ischemic optic neuropathy becoming bilateral despite corticosteroid therapy]. Journal francais d'ophtalmologie, 2016, Volume: 39, Issue:1 Topics: Acute Disease; Aged; Alzheimer Disease; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Disease P	2016
Utilization of over the counter medication among pregnant women; a cross-sectional study conducted at Isra University Hospital, Hyderabad. JPMA. The Journal of the Pakistan Medical Association, 2016, Volume: 66, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal;	2016
Aspirin and loxoprofen relieve refractory pruritus in patients with prurigo nodularis. The Journal of dermatology, 2016, Volume: 43, Issue:9 Topics: Administration, Cutaneous; Administration, Oral; Anti-Bacterial Agents; Anti-Inflammatory Agents, No	2016
Rare case of bilateral traumatic internal carotid artery dissection. BMJ case reports, 2016, Sep-20, Volume: 2016 Topics: Aspirin; Carotid Artery, Internal, Dissection; Clopidogrel; Headache; Humans; Infarction, Anterior C	2016
Comparison of stadol NS and fiorinal with codeine. Headache, 1999, Volume: 39, Issue:2 Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Aspirin; Barbiturates; Butorph	1999
45-year-old woman with recurrent headache and photophobia. Mayo Clinic proceedings, 2008, Volume: 83, Issue:8 Topics: Acyclovir; Anti-Bacterial Agents; Antiviral Agents; Aspirin; Diagnosis, Differential; Female; Headac	2008
[Inhibition of platelet aggregation and angiotensin II-receptor blockade following TIA; the unexpected results of the Prevention Regimen For Effectively Avoiding Second Strokes (PROFESS) trial]. Nederlands tijdschrift voor geneeskunde, 2008, Aug-30, Volume: 152, Issue:35 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Aspirin; Benzimida	2008
Low-dose acetylsalicylic Acid analog and acetazolamide for prevention of acute mountain sickness. High altitude medicine & biology, 2008,Winter, Volume: 9, Issue:4 Topics: Acetazolamide; Acute Disease; Altitude Sickness; Aspirin; Dose-Response Relationship, Drug; Headache	2008
Risk indicators for development of headache during dipyridamole treatment after cerebral ischaemia of arterial origin. Journal of neurology, neurosurgery, and psychiatry, 2009, Volume: 80, Issue:4 Topics: Aged; Aspirin; Brain Ischemia; Cerebral Arteries; Dipyridamole; Drug Therapy, Combination; Female; H	2009
Moyamoya disease in an 8-year-old boy presenting with weakness. Pediatric emergency care, 2009, Volume: 25, Issue:5 Topics: Anti-Inflammatory Agents; Aspirin; Attention Deficit Disorder with Hyperactivity; Brain Ischemia; Ch	2009
A case of ecchordosis physaliphora presenting with an intratumoral hemorrhage. Turkish neurosurgery, 2009, Volume: 19, Issue:3 Topics: Aspirin; Brain Diseases; Cranial Fossa, Posterior; Hamartoma; Headache; Humans; Magnetic Resonance I	2009
JAK2V617F mutation-positive childhood essential thrombocythemia associated with cerebral venous sinus thrombosis. Journal of pediatric hematology/oncology, 2009, Volume: 31, Issue:9 Topics: Aspirin; Child; Clone Cells; Cytotoxins; Diagnosis, Differential; Female; Headache; Humans; Hydroxyu	2009
Headache as the sole presenting symptom of acute myocardial infarction. The Journal of the Association of Physicians of India, 2009, Volume: 57 Topics: Angioplasty, Balloon, Coronary; Anticholesteremic Agents; Aspirin; Atorvastatin; Clopidogrel; Headac	2009
How can stretching maneuvers involving the neck cause vertebral artery dissection and transient ischemic attack? Journal of occupational and environmental medicine, 2010, Volume: 52, Issue:7 Topics: Adult; Aged; Aspirin; Confusion; Headache; Heparin; Humans; Ischemic Attack, Transient; Muscle Stret	2010
A hangover remedy for the holidays? Consumer reports, 2011, Volume: 76, Issue:1 Topics: Alcohol Drinking; Aspirin; Caffeine; Headache; Humans; Pain; Pain Management	2011
Postpartum headache due to spontaneous cervical artery dissection. Headache, 2011, Volume: 51, Issue:5 Topics: Adult; Aspirin; Carotid Artery, Internal, Dissection; Female; Headache; Humans; Platelet Aggregation	2011
Intravenous aspirin (lysine acetylsalicylate) in the inpatient management of headache. Neurology, 2011, Apr-05, Volume: 76, Issue:14 Topics: Aspirin; Disease Management; Headache; Humans; Infusions, Intravenous; Randomized Controlled Trials	2011
[Self-medication of regular headache: a community pharmacy-based survey in Belgium]. Journal de pharmacie de Belgique, 2012, Issue:2 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster	2012
3 cases of primary intracranial hemorrhage associated with "Molly", a purified form of 3,4-methylenedioxymethamphetamine (MDMA). Journal of the neurological sciences, 2012, Dec-15, Volume: 323, Issue:1-2 Topics: Adult; Alcohol Drinking; Amphetamine-Related Disorders; Anticoagulants; Aspirin; Cerebral Angiograph	2012
Two cases of pediatric essential thrombocythemia managed effectively with hydroxyurea. International journal of hematology, 2012, Volume: 96, Issue:6 Topics: Aspirin; Asymptomatic Diseases; Bone Marrow; Child; Child, Preschool; Female; Headache; Humans; Hydr	2012
[Acute analgesic-induced renal papillary necrosis]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2013, Volume: 185, Issue:4 Topics: Analgesics; Aspirin; Diagnosis, Differential; Dose-Response Relationship, Drug; Female; Headache; He	2013
Reversible cerebral vasoconstriction syndrome and bilateral vertebral artery dissection presenting in a patient after cesarean section. BMJ case reports, 2013, Jan-24, Volume: 2013 Topics: Aspirin; Cerebral Angiography; Cesarean Section; Clopidogrel; Female; Headache; Humans; Magnetic Res	2013
Generalized lichen planus-like eruption due to acetylsalicylic acid. Journal of the European Academy of Dermatology and Venereology : JEADV, 2003, Volume: 17, Issue:4 Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Aspirin; Biopsy, Needle; Drug Eruptions; Female; F	2003
Fiorinal for symptomatic treatment of nonvascular headache. Missouri medicine, 1953, Volume: 50, Issue:4 Topics: Analgesics; Aspirin; Barbiturates; Caffeine; Drug Combinations; Headache; Humans	1953
Clinical and blood chemical studies with ascriptin; with particular reference to headaches and arthritic pains. New York state journal of medicine, 1958, Mar-01, Volume: 58, Issue:5 Topics: Aluminum Hydroxide; Antacids; Arthritis; Aspirin; Drug Combinations; Headache; Humans; Magnesium Hyd	1958
Evaluation of a salicylamide compound in the treatment of headache. Medical bulletin (Ann Arbor, Mich.), 1958, Volume: 24, Issue:10 Topics: Aspirin; Headache; Humans; Salicylamides	1958
Effectiveness of a new analgesic-calmative preparation and acetylsalicylic acid in the treatment of headache and other pain. Mississippi Valley medical journal (Quincy, Ill), 1959, Volume: 81, Issue:4 Topics: Analgesics; Anti-Allergic Agents; Aspirin; Caffeine; Headache; Histamine H1 Antagonists; Humans; Pai	1959
[CLINICAL USE OF TH-2152. APROPOS OF 57 CASES]. Lyon medical, 1964, May-10, Volume: 211 Topics: Analgesia; Aspirin; Carbonates; Fever; Headache; Humans; Infections; Neoplasms; Neuralgia; Pain Mana	1964
COMPARATIVE EFFECTIVENESS OF THREE ORAL MEDICATIONS IN SINUSTIS AND RHINITIS; A DOUBLE-BLIND STUDY. Medical times, 1964, Volume: 92 Topics: Anti-Allergic Agents; Aspirin; Biomedical Research; Codeine; Double-Blind Method; Headache; Histamin	1964
[USE OF TH-2152 IN PAINFUL SYNDROMES]. Gazette medicale de France, 1964, Jun-10, Volume: 71 Topics: Abscess; Analgesia; Aspirin; Back Pain; Bicarbonates; Biomedical Research; Burns; Craniocerebral Tra	1964
[THE USE OF SALICYLIC ACID DERIVATIVES IN PEDIATRICS]. Gazette medicale de France, 1964, Jun-10, Volume: 71 Topics: Analgesia; Aspirin; Bicarbonates; Biomedical Research; Child; Headache; Infant; Joint Diseases; Pedi	1964
[CLINICAL EXPERIMENTATION WITH TH-2152 IN GYNECOLOGY AND OBSTETRICS]. Gazette medicale de France, 1964, Jun-10, Volume: 71 Topics: Analgesia; Aspirin; Bicarbonates; Biomedical Research; Dysmenorrhea; Female; Gynecology; Headache; H	1964
[TRIALS WITH TH-2152 (CATALGINE). (APROPOS OF 397 CASES)]. Gazette medicale de France, 1964, Jun-10, Volume: 71 Topics: Arthritis; Aspirin; Bicarbonates; Biomedical Research; Headache; Humans; Influenza, Human; Joint Dis	1964
DRUGS FOR HEADACHE OF MIGRAINOUS, VASCULAR OR MUSCULAR ORIGIN. Canadian Medical Association journal, 1964, Jul-25, Volume: 91 Topics: Aspirin; Caffeine; Cardiovascular Agents; Ergot Alkaloids; Ergotamine; Headache; Humans; Meprobamate	1964
THE EFFECTS OF THERAPY WITH A NONDEPRESSANT ANALGESIC COMBINATION. Current therapeutic research, clinical and experimental, 1964, Volume: 6 Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Arthritis; Aspirin; Biomedical Research; Caffein	1964
PHENACETIN NEPHROPATHY. Canadian Medical Association journal, 1965, Jan-09, Volume: 92 Topics: Acidosis; Animals; Aspirin; Bacteriuria; Biological Transport; Caffeine; Codeine; Dogs; Drug Therapy	1965
ANALGESIC COMBINATION IN HEADACHE. Headache, 1965, Volume: 5 Topics: Analgesics; Arthritis; Aspirin; Back Pain; Caffeine; Cervical Vertebrae; Drug Therapy; Headache; Hum	1965
NEPHROPATHY ASSOCIATED WITH THE USE OF ANALGESIC MEDICATIONS. Annals of internal medicine, 1965, Volume: 62 Topics: Acute Kidney Injury; Amobarbital; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antip	1965
DOUBLE-BLIND COMPARISON OF NAMOXYRATE, CODEINE, ASPIRIN, AND PLACEBO. Current therapeutic research, clinical and experimental, 1965, Volume: 7 Topics: Analgesia; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Biomedical Research; Codeine	1965
TENSION HEADACHE: A NEW AGENT FOR ITS SYMPTOMATIC RELIEF. Headache, 1965, Volume: 5 Topics: Aspirin; Barbiturates; Caffeine; Diagnosis; Drug Therapy; Headache; Humans; Mental Disorders; Phenac	1965
Acute onset of bilateral myoclonus in a 16-year-old female. Journal of the Mississippi State Medical Association, 2004, Volume: 45, Issue:6 Topics: Acetaminophen; Acute Disease; Adolescent; Aspirin; Attention Deficit Disorder with Hyperactivity; Ca	2004
Kawasaki disease: are we missing the diagnosis? Indian journal of pediatrics, 2005, Volume: 72, Issue:10 Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Child, Preschool; Diagnosis, D	2005
A questionnaire-based study on prevalence and treatment of headache in young children. The journal of headache and pain, 2005, Volume: 6, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Female; Headache; Humans; Incidence; Male;	2005
The risks and safety of clopidogrel in pediatric arterial ischemic stroke. Stroke, 2006, Volume: 37, Issue:4 Topics: Adolescent; Aspirin; Brain Ischemia; Child; Child, Preschool; Clopidogrel; Cohort Studies; Drug Ther	2006
Use and misuse of aspirin in rural Ethiopia. East African medical journal, 2006, Volume: 83, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Child; Cross-Sectional Studies; Ethiopia; Female; F	2006
Acetylsalicylic acid, paracetamol and caffeine combination in headache. Cephalalgia : an international journal of headache, 2006, Volume: 26, Issue:10 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine;	2006
[Chronic interstitial nephritis in an 18-year-old due to intake of a compound analgesic]. Medizinische Klinik (Munich, Germany : 1983), 2006, Oct-15, Volume: 101, Issue:10 Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy; Caffeine; Creat	2006
The fixed combination of acetylsalicylic acid, paracetamol and caffeine. Cephalalgia : an international journal of headache, 2006, Volume: 26, Issue:12 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine;	2006
From the nutcracker-phenomenon of the left renal vein to the midline congestion syndrome as a cause of migraine, headache, back and abdominal pain and functional disorders of pelvic organs. Medical hypotheses, 2007, Volume: 68, Issue:6 Topics: Abdominal Pain; Adolescent; Aspirin; Back Pain; Child; Child, Preschool; Constriction, Pathologic; D	2007
[The combination of acetylsalicylic acid and dipyridamole is more effective in secondary prevention following transient ischaemic attack or cerebral infarction: the debate is closed]. Nederlands tijdschrift voor geneeskunde, 2006, Dec-02, Volume: 150, Issue:48 Topics: Aspirin; Cerebral Infarction; Dipyridamole; Headache; Humans; Ischemic Attack, Transient; Platelet A	2006
Intracranial hypotension following motor vehicle accident: an overlooked cause of post-traumatic head and neck pain? Pain practice : the official journal of World Institute of Pain, 2007, Volume: 7, Issue:1 Topics: Accidents, Traffic; Analgesics; Aspirin; Blood Patch, Epidural; Diplopia; Drug Therapy, Combination;	2007
Analgesic nephropathy. Kidney international, 2007, Volume: 72, Issue:4 Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Aspirin; Drug Combinations; Headache; Humans; Kidney	2007
Benign long-term outcome of conservatively treated cervical aneurysms due to carotid dissection. Neurology, 2007, Jul-31, Volume: 69, Issue:5 Topics: Adult; Aged; Aneurysm, Ruptured; Anticoagulants; Aortic Dissection; Aspirin; Carotid Artery, Interna	2007
Fiorinal and other sedative-analgesic drugs for "tension" headache. The Medical letter on drugs and therapeutics, 1967, May-19, Volume: 9, Issue:10 Topics: Aspirin; Barbiturates; Caffeine; Codeine; Headache; Humans; Phenacetin	1967
Drugs for pain in the elderly. Geriatrics, 1982, Volume: 37, Issue:2 Topics: Aged; Analgesics; Anti-Inflammatory Agents; Anticonvulsants; Arteritis; Arthritis; Aspirin; Geriatri	1982
[New contributions on extinction tests of essential headache. I. The test with lysine acetylsalicylate]. Bollettino della Societa italiana di biologia sperimentale, 1983, Aug-30, Volume: 59, Issue:8 Topics: Adult; Analgesics; Aspirin; beta-Endorphin; Endorphins; Female; Headache; Humans; Lysine; Male	1983
Do aspirin and acetaminophen affect total menstrual loss? Gynecologic and obstetric investigation, 1984, Volume: 18, Issue:3 Topics: Acetaminophen; Adolescent; Adult; Analgesics; Aspirin; Double-Blind Method; Dysmenorrhea; Female; He	1984
Headache--diagnosis and effective management. The Western journal of medicine, 1984, Volume: 140, Issue:6 Topics: Analgesics; Aspirin; Barbiturates; Caffeine; Cluster Headache; Drug Combinations; Ergotamine; Headac	1984
A plain man's guide to the management of migraine. British medical journal (Clinical research ed.), 1982, Apr-10, Volume: 284, Issue:6322 Topics: Acetaminophen; Aspirin; Ergotamine; Headache; Humans; Metoclopramide; Migraine Disorders; Sleep	1982
[Clinical study of the labour inhibiting effects an side effects of acetylsalicylic acid (ASA) (author's transl)]. Geburtshilfe und Frauenheilkunde, 1981, Volume: 41, Issue:2 Topics: Aspirin; Female; Fenoterol; Headache; Humans; Hyperventilation; Obstetric Labor, Premature; Pregnanc	1981
Aspirin intolerance presenting as chronic rhinitis. Rhode Island medical journal, 1980, Volume: 63, Issue:3 Topics: Aspirin; Chronic Disease; Diagnosis, Differential; Drug Hypersensitivity; Eosinophilia; Female; Head	1980
Acetaminophen and aspirin. Prescription, use, and accidental ingestion among children. American journal of diseases of children (1960), 1982, Volume: 136, Issue:11 Topics: Acetaminophen; Adolescent; Aspirin; Child; Child, Preschool; Drug Prescriptions; Drug Utilization; F	1982
Pulmonary edema in a 52-year-old woman ingesting large amounts of aspirin. JAMA, 1981, Nov-13, Volume: 246, Issue:19 Topics: Aspirin; Female; Headache; Humans; Middle Aged; Pulmonary Edema; Radiography	1981
Newer drug therapies for headache. Postgraduate medicine, 1980, Volume: 68, Issue:1 Topics: Antidepressive Agents; Aspirin; Bromocriptine; Clonidine; Cluster Headache; Dipyridamole; Headache;	1980
Branch retinal artery occlusion in pregnancy. British journal of obstetrics and gynaecology, 1994, Volume: 101, Issue:1 Topics: Adult; Aspirin; Female; Headache; Humans; Pregnancy; Pregnancy Complications, Cardiovascular; Recurr	1994
[Pharmacology of anti-migraine drugs]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1993, Jan-10, Volume: 82, Issue:1 Topics: Aspirin; Ergotamine; Headache; Humans; Inflammation; Mental Disorders; Muscle Contraction; Neuralgia	1993
[Aspirin: as recommended by WHO]. La Clinica terapeutica, 1993, Volume: 142, Issue:3 Topics: Analgesics; Aspirin; Dose-Response Relationship, Drug; Headache; Humans; Migraine Disorders; World H	1993
Toxic reaction to salicylate in a newborn infant: similarities to neonatal sepsis. The Journal of pediatrics, 1993, Volume: 122, Issue:6 Topics: Aspirin; Diagnosis, Differential; Female; Fetus; Headache; Humans; Infant, Newborn; Infections; Pois	1993
Headaches and the primary care pediatrician. Pediatric annals, 1995, Volume: 24, Issue:9 Topics: Analgesics; Aspirin; Headache; Health Maintenance Organizations; Humans; Pediatrics; Primary Health	1995
Over-the-counter analgesics and kidney disease. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1996, Volume: 27, Issue:6 Topics: Acetaminophen; Analgesics; Aspirin; Drug Combinations; Headache; Humans; Kidney Diseases; Nonprescri	1996
Granulomatous hepatitis induced by aspirin-kodein analgesics. Journal of internal medicine, 1996, Volume: 239, Issue:3 Topics: Analgesics; Aspirin; Biopsy; Chemical and Drug Induced Liver Injury; Codeine; Drug Combinations; Gra	1996
Hypoglossal nerve paresis caused by spontaneous dissection of kinked internal carotid artery--case report. Neurologia medico-chirurgica, 1998, Volume: 38, Issue:3 Topics: Aortic Dissection; Aspirin; Carotid Artery, Internal; Cranial Nerve Diseases; Dysarthria; Headache;	1998
High-altitude headache. Health news (Waltham, Mass.), 1998, Jun-01, Volume: 4, Issue:7 Topics: Altitude Sickness; Aspirin; Headache; Humans	1998
Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:9 Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, No	1998
Craniofacial pain followed by scalp necrosis and stroke. An unusual presentation of the primary antiphospholipid syndrome. Journal of neurology, 1999, Volume: 246, Issue:2 Topics: Aged; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Autoimmune D	1999
Comparison of the effects of acetylsalicylic acid, ticlopidine and cilostazol on primary hemostasis using a quantitative bleeding time test apparatus. Haemostasis, 1999, Volume: 29, Issue:5 Topics: Adult; Aspirin; Bleeding Time; Cilostazol; Fibrinolytic Agents; Gastrointestinal Diseases; Headache;	1999
Dental erosion and aspirin headache powders: a clinical report. Journal of prosthodontics : official journal of the American College of Prosthodontists, 2000, Volume: 9, Issue:2 Topics: Administration, Sublingual; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Crowns; Female;	2000
Diabetes mellitus with left transverse sinus thrombosis and right transverse sinus aplasia. Diabetes research and clinical practice, 2001, Volume: 51, Issue:1 Topics: Aged; Aspirin; Cerebral Angiography; Cranial Sinuses; Diabetes Mellitus, Type 2; Diabetic Angiopathi	2001
Drug Points: tachycardia associated with moxifloxacin. BMJ (Clinical research ed.), 2001, Jan-06, Volume: 322, Issue:7277 Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Aza Compounds; Bronchitis;	2001
[Fernand Widal syndrome: apropos of 2 cases]. Dakar medical, 1999, Volume: 44, Issue:2 Topics: Adult; Airway Obstruction; Aspirin; Asthma; Cyclooxygenase Inhibitors; Female; Headache; Humans; Hyp	1999
"Shiatsu sympathectomy": ICA dissection associated with a shiatsu massager. Neurology, 2002, Apr-23, Volume: 58, Issue:8 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carotid Artery Injuries; Female; Headache; Humans;	2002
Chronopharmacokinetics of ethanol. III. Variation in rate of ethanolemia decay in human subjects. International journal of clinical pharmacology and biopharmacy, 1978, Volume: 16, Issue:12 Topics: Adult; Aspirin; Ethanol; Headache; Humans; Kinetics; Male; Middle Aged	1978
[Pain suppression in childhood]. Wiener medizinische Wochenschrift (1946), 1977, Volume: 127, Issue:4 Topics: Age Factors; Aminopyrine; Analgesics; Aspirin; Body Weight; Child, Preschool; Headache; Humans; Infa	1977
Letter: Aspirin hepatotoxicity. Annals of internal medicine, 1975, Volume: 82, Issue:4 Topics: Adult; Aspirin; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Common Cold; Female; Headach	1975
Trauma of cervical spine as cause of chronic headache. The Journal of trauma, 1975, Volume: 15, Issue:5 Topics: Adolescent; Adult; Aged; Aspirin; Cervical Vertebrae; Child; Chronic Disease; Female; Food Hypersens	1975
Diseases of the central nervous system. Relief of pain: headache, facial neuralgia, migraine, and phantom limb. British medical journal, 1975, Oct-11, Volume: 4, Issue:5988 Topics: Analgesics; Aspirin; Carbamazepine; Ergotamines; Facial Neuralgia; Giant Cell Arteritis; Headache; H	1975
Intravascular coagulation in acute lupus erythematosus. JAMA, 1975, Nov-03, Volume: 234, Issue:5 Topics: Acute Disease; Adult; Aspirin; Disseminated Intravascular Coagulation; Female; Headache; Hemolysis;	1975
Young woman with headaches and pulmonary edema. Indiana medicine : the journal of the Indiana State Medical Association, 1991, Volume: 84, Issue:2 Topics: Adult; Aspirin; Drug Overdose; Female; Headache; Humans; Pulmonary Edema; Radiography; Self Administ	1991
Drug abuse and headache. The Medical clinics of North America, 1991, Volume: 75, Issue:3 Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Ergot Alkaloi	1991
[A staged program for treatment of headache syndromes with low dose acetylsalicylic acid]. Zeitschrift fur arztliche Fortbildung, 1991, Jan-25, Volume: 85, Issue:1-2 Topics: Aspirin; Blood; Combined Modality Therapy; Dose-Response Relationship, Drug; Headache; Heparin; Huma	1991
A protocol for butalbital, aspirin and caffeine (BAC) detoxification in headache patients. Headache, 1990, Volume: 30, Issue:8 Topics: Adult; Aspirin; Barbiturates; Caffeine; Clinical Protocols; Combined Modality Therapy; Female; Heada	1990
Delirious woman with disabling headaches. Hospital practice (Office ed.), 1988, Apr-15, Volume: 23, Issue:4 Topics: Acid-Base Imbalance; Aspirin; Dementia; Female; Headache; Humans; Medication Errors; Middle Aged; Se	1988
Intravenous aspirin for intractable headache and facial pain. Headache, 1988, Volume: 28, Issue:1 Topics: Adult; Aspirin; Facial Pain; Headache; Humans; Infusions, Intravenous; Middle Aged	1988
Food sensitivity or analgesic withdrawal? Headache, 1987, Volume: 27, Issue:6 Topics: Aspirin; Diet; Headache; Humans	1987
A classification of headache. International ophthalmology clinics, 1970,Fall, Volume: 10, Issue:3 Topics: Antidepressive Agents; Anxiety; Arteritis; Aspirin; Depression; Ergot Alkaloids; Facial Neuralgia; H	1970
Pain in haemophilia. Lancet (London, England), 1973, May-05, Volume: 1, Issue:7810 Topics: Acetaminophen; Analgesics; Aspirin; Codeine; Cryotherapy; Gastrointestinal Hemorrhage; Headache; Hem	1973
Acetylsalicylic acid as a cause of pancytopenia from bone-marrow damage. Lancet (London, England), 1966, Oct-08, Volume: 2, Issue:7467 Topics: Adult; Aged; Anemia, Aplastic; Aspirin; Blood Platelets; Bone Marrow Diseases; Female; Headache; Hem	1966
[The effect of various drugs in clinical use on thrombocyte functions]. Folia haematologica (Leipzig, Germany : 1928), 1969, Volume: 92, Issue:4 Topics: Adolescent; Adult; Aged; Aminobenzoates; Aminocaproates; Arthritis, Rheumatoid; Aspirin; Blood Coagu	1969
The diagnosis and treatment of cerebral concussion. International surgery, 1967, Volume: 47, Issue:4 Topics: Ascorbic Acid; Aspirin; Brain Concussion; Cerebral Ventriculography; Cortisone; Diphenhydramine; Ele	1967
Survey of adolescent drug use. I. Sex and grade distribution. American journal of public health, 1971, Volume: 61, Issue:12 Topics: Adolescent; Age Factors; Alcohol Drinking; Amphetamine; Aspirin; Barbiturates; Cannabis; Cocaine; De	1971
[Clinical study of a new antalgic: Propofan]. Lyon medical, 1972, Jan-23, Volume: 227, Issue:2 Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Caffeine; Dextropropoxyphene; Female; Headache; His	1972
[Octadon N]. Therapie der Gegenwart, 1974, Volume: 113, Issue:7 Topics: Analgesics; Aspirin; Caffeine; Drug Combinations; Germany, West; Headache; Humans; Migraine Disorder	1974
The interesting case of furan aspirin. Texas reports on biology and medicine, 1972,Summer, Volume: 30, Issue:2 Topics: Animals; Aspirin; Drug Combinations; Furans; Headache; History, 20th Century; Humans; Male; Rats; Un	1972
Reflections on the treatment of headache. Headache, 1972, Volume: 11, Issue:4 Topics: Animals; Aspirin; Cyproheptadine; Ergotamine; Haplorhini; Headache; Hormones; Humans; Methysergide;	1972
The origins of analgesic nephropathy. The British journal of psychiatry : the journal of mental science, 1973, Volume: 123, Issue:572 Topics: Adult; Affective Symptoms; Aged; Alcoholism; Analgesics; Antipyrine; Aspirin; Codeine; Creatinine; F	1973
Q fever. British medical journal, 1973, Apr-07, Volume: 2, Issue:5857 Topics: Acetaminophen; Animals; Aspirin; Cattle; Coxiella; Disease Reservoirs; Feces; Fever; Headache; Human	1973
[Salicylate poisoning by percutaneous resorption]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1973, Volume: 24, Issue:12 Topics: Administration, Topical; Aspirin; Deafness; Epistaxis; Female; Hallucinations; Headache; Humans; Poi	1973
Altitude headache. Headache, 1972, Volume: 12, Issue:3 Topics: Acetazolamide; Altitude; Ammonium Chloride; Aspirin; Furosemide; Headache; Humans; Hypoxia; Potassiu	1972
Headache nostrums and chronic illness. Journal of chronic diseases, 1966, Volume: 19, Issue:10 Topics: Analgesics; Aspirin; Chronic Disease; Gastrointestinal Hemorrhage; Headache; Kidney Diseases; Monoam	1966
"Fiorinal" in the treatment of tension headache and other painful states associated with nervous tension. The Medical journal of Australia, 1968, Feb-17, Volume: 1, Issue:7 Topics: Adolescent; Adult; Analgesics; Aspirin; Barbiturates; Caffeine; Dysmenorrhea; Female; Headache; Huma	1968
Analgesic habits of 500 veterans: incidence and complications of abuse. Canadian Medical Association journal, 1968, Mar-30, Volume: 98, Issue:13 Topics: Adult; Aged; Analgesics; Anemia; Arthritis; Aspirin; Caffeine; Canada; Codeine; Gastrointestinal Hem	1968
[Tension headache. Treatment using FIO]. Hospital (Rio de Janeiro, Brazil), 1968, Volume: 74, Issue:2 Topics: Adult; Aged; Aspirin; Barbiturates; Caffeine; Drug Synergism; Female; Headache; Humans; Male; Middle	1968
[Headache (4): tension headache]. Lakartidningen, 1970, Oct-21, Volume: 67, Issue:43 Topics: Aspirin; Headache; Humans; Muscle Contraction; Nicotinic Acids	1970
[Use and misuse of light analgetics for headache]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1971, Mar-10, Volume: 91, Issue:7 Topics: Acetaminophen; Antipyrine; Aspirin; Dextropropoxyphene; Headache; Humans; Phenacetin; Salicylamides;	1971
[Control of pain with target therapy with "Spasmo-Dolviran"]. Hippokrates, 1967, Apr-15, Volume: 38, Issue:7 Topics: Analgesics; Aspirin; Codeine; Female; Headache; Humans; Menopause; Neuralgia; Pain; Phenacetin; Phen	1967
Syndrome associated with the abuse of analgesics. Annals of internal medicine, 1968, Volume: 68, Issue:4 Topics: Adult; Age Factors; Analgesics; Anemia; Animals; Aspirin; Caffeine; Cats; Dogs; Female; Guinea Pigs;	1968

aspirin and Bilateral Headache