aspirin has been researched along with B16 Melanoma in 12 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thromboxane A2 (TXA2) was the prostanoid product of COX-1 responsible for this antimetastatic effect." | 1.51 | Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2. ( Allen, PD; Armstrong, PC; Cerutti, C; Gil-Bernabé, AM; Gomes, AL; Lucotti, S; Markelc, B; Mitchell, JA; Muschel, RJ; Ridley, AJ; Smart, S; Soyer, M; Warner, TD; Watson, K, 2019) |
| " Interestingly, the acute toxic death could not be reached at the maximum administrable dose (5 g/kg)." | 1.42 | Aspirin, lysine, mifepristone and doxycycline combined can effectively and safely prevent and treat cancer metastasis: prevent seeds from gemmating on soil. ( Dong, H; Gao, Y; Jia, L; Li, T; Lu, Y; Ma, J; Shao, J; Tu, X; Wan, L; Wang, J; Xie, F; Xie, J; Xu, B; Xu, H; Zhang, T; Zhu, Y, 2015) |
| " As determined by Toxilight-cytotoxicity assay, the drug was only toxic to the cancer cells at 100 microM." | 1.33 | Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells. ( Chiu, LC; Ooi, VE; Tong, KF, 2005) |
| "Both the B16 melanoma and the MMTV carcinoma parental cell lines, which can be classed as intermediate metastatic, aggregated platelets well." | 1.27 | Tumour-cell-induced platelet aggregation: studies with cloned metastatic and non-metastatic variants. ( Crawford, N; Lampugnani, MG, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thyagarajan, A | 1 |
| Saylae, J | 1 |
| Sahu, RP | 1 |
| Lucotti, S | 1 |
| Cerutti, C | 1 |
| Soyer, M | 1 |
| Gil-Bernabé, AM | 1 |
| Gomes, AL | 1 |
| Allen, PD | 1 |
| Smart, S | 1 |
| Markelc, B | 1 |
| Watson, K | 1 |
| Armstrong, PC | 1 |
| Mitchell, JA | 1 |
| Warner, TD | 1 |
| Ridley, AJ | 1 |
| Muschel, RJ | 1 |
| Vad, NM | 1 |
| Kudugunti, SK | 1 |
| Wang, H | 1 |
| Bhat, GJ | 1 |
| Moridani, MY | 1 |
| Wan, L | 1 |
| Dong, H | 1 |
| Xu, H | 1 |
| Ma, J | 1 |
| Zhu, Y | 1 |
| Lu, Y | 1 |
| Wang, J | 1 |
| Zhang, T | 1 |
| Li, T | 1 |
| Xie, J | 1 |
| Xu, B | 1 |
| Xie, F | 1 |
| Gao, Y | 1 |
| Shao, J | 1 |
| Tu, X | 1 |
| Jia, L | 1 |
| Tsai, CS | 1 |
| Luo, SF | 1 |
| Ning, CC | 1 |
| Lin, CL | 1 |
| Jiang, MC | 1 |
| Liao, CF | 1 |
| Ordan, O | 1 |
| Rotem, R | 1 |
| Jaspers, I | 1 |
| Flescher, E | 1 |
| Chiu, LC | 1 |
| Tong, KF | 1 |
| Ooi, VE | 1 |
| Sato, K | 1 |
| Takahashi, H | 1 |
| Iraha, R | 1 |
| Toriyama, M | 1 |
| Uluçkan, O | 1 |
| Eagleton, MC | 1 |
| Floyd, DH | 1 |
| Morgan, EA | 1 |
| Hirbe, AC | 1 |
| Kramer, M | 1 |
| Dowland, N | 1 |
| Prior, JL | 1 |
| Piwnica-Worms, D | 1 |
| Jeong, SS | 1 |
| Chen, R | 1 |
| Weilbaecher, K | 1 |
| Ferrario, A | 1 |
| Gomer, CJ | 1 |
| Talmadge, JE | 1 |
| Bowersox, O | 1 |
| Tribble, H | 1 |
| Shepard, M | 1 |
| Liggitt, D | 1 |
| Lampugnani, MG | 1 |
| Crawford, N | 1 |
12 other studies available for aspirin and B16 Melanoma
| Article | Year |
|---|---|
Acetylsalicylic acid inhibits the growth of melanoma tumors via SOX2-dependent-PAF-R-independent signaling pathway.
Topics: Animals; Apoptosis; Aspirin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dinoprost; Dinopro | 2017 |
Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cell Line, Tumor; Cycloo | 2019 |
Efficacy of acetylsalicylic acid (aspirin) in skin B16-F0 melanoma tumor-bearing C57BL/6 mice.
Topics: Alanine Transaminase; Animals; Anticarcinogenic Agents; Aspirin; Glutathione; Kidney; Lipid Peroxida | 2014 |
Aspirin, lysine, mifepristone and doxycycline combined can effectively and safely prevent and treat cancer metastasis: prevent seeds from gemmating on soil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Doxycycline; Drug Interactions; Fe | 2015 |
Acetylsalicylic acid regulates MMP-2 activity and inhibits colorectal invasion of murine B16F0 melanoma cells in C57BL/6J mice: effects of prostaglandin F(2)alpha.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasm | 2009 |
Stress-responsive JNK mitogen-activated protein kinase mediates aspirin-induced suppression of B16 melanoma cellular proliferation.
Topics: Anticarcinogenic Agents; Aspirin; Cell Death; Drug Synergism; Genes, jun; Humans; JNK Mitogen-Activa | 2003 |
Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells.
Topics: Antineoplastic Agents; Aspirin; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Cyclooxygen | 2005 |
Down-regulation of tyrosinase expression by acetylsalicylic acid in murine B16 melanoma.
Topics: Animals; Aspirin; Cell Line, Tumor; Cell Proliferation; Dihydroxyphenylalanine; Down-Regulation; Mel | 2008 |
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apyrase; Aspirin; Bone Neoplasms; Diagnosti | 2008 |
Systemic toxicity in mice induced by localized porphyrin photodynamic therapy.
Topics: Animals; Aspirin; Blood Cell Count; Dihematoporphyrin Ether; Dose-Response Relationship, Radiation; | 1990 |
Therapeutic and toxic activity of tumor necrosis factor is synergistic with gamma interferon.
Topics: Animals; Aspirin; Cells, Cultured; Dexamethasone; Drug Synergism; Immunotherapy; Injections, Intrape | 1989 |
Tumour-cell-induced platelet aggregation: studies with cloned metastatic and non-metastatic variants.
Topics: Adenosine Diphosphate; Animals; Aspirin; Cell Line; Creatine Kinase; Heparin; Humans; Mammary Neopla | 1987 |