Page last updated: 2024-10-23

aspirin and Asymptomatic Conditions

aspirin has been researched along with Asymptomatic Conditions in 29 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"Prospective cohort study as a secondary analysis of the Effects of Aspirin in Gestation and Reproduction randomized controlled trial of preconception-initiated low-dose aspirin among women with one or two prior pregnancy losses."9.34Physical activity and incidence of subclinical and clinical pregnancy loss: a secondary analysis in the effects of aspirin in gestation and reproduction randomized trial. ( Freeman, JR; Grewal, J; Mumford, SL; Perkins, NJ; Russo, LM; Schisterman, EF; Schliep, KC; Silver, RM; Sjaarda, LA; Whitcomb, BW, 2020)
"Orchitis is characterized by acute or chronic testicular inflammation and is a primary cause of male infertility."5.62Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice ( Chen, X; Ding, W; Jin, L; Lai, R; Liu, Y; Mwangi, J; Qiu, H; Zhao, L; Zhu, T, 2021)
"Aspirin resistance was measured by the PFA-100 system (collagen/epinephrine cartridge) and glycoprotein IIIa P1A1/A2 polymorphism was determined by PCR."5.43Aspirin resistance in cerebrovascular disease and the role of glycoprotein IIIa polymorphism in Turkish stroke patients. ( Ataç, BF; Bayraktar, N; Can, U; Çelikkol, C; Derle, E; Kibaroğlu, S; Öcal, R; Verdi, H, 2016)
"Prospective cohort study as a secondary analysis of the Effects of Aspirin in Gestation and Reproduction randomized controlled trial of preconception-initiated low-dose aspirin among women with one or two prior pregnancy losses."5.34Physical activity and incidence of subclinical and clinical pregnancy loss: a secondary analysis in the effects of aspirin in gestation and reproduction randomized trial. ( Freeman, JR; Grewal, J; Mumford, SL; Perkins, NJ; Russo, LM; Schisterman, EF; Schliep, KC; Silver, RM; Sjaarda, LA; Whitcomb, BW, 2020)
"Semi-structured interviews with people who were eligible but had declined to participate in the Aspirin for Asymptomatic Atherosclerosis (AAA) trial (N = 11), and AAA trial participants who had stopped taking the trial medication (N = 11)."5.15Accrual and drop out in a primary prevention randomised controlled trial: qualitative study. ( Cunningham-Burley, S; Eborall, HC; Fowkes, FG; Price, JF; Stewart, MC, 2011)
" Data from one randomised controlled trial showed no significant difference in benefit with aspirin versus placebo in asymptomatic carotid stenosis, but it is still reasonable to recommend aspirin (81-325 mg daily) for prevention of vascular events in these patients."5.01Optimal Antiplatelet Therapy in Moderate to Severe Asymptomatic and Symptomatic Carotid Stenosis: A Comprehensive Review of the Literature. ( de Borst, GJ; Halliday, A; Hamilton, G; Kakkos, S; McCabe, DJH; Murphy, SJX; Naylor, AR; Ricco, JB; Sillesen, H; Vega de Ceniga, M, 2019)
"A case of asymptomatic eosinophilia in the setting of acetylsalicylic acid (aspirin) use was presented, followed by discussion of the clinical characteristics, diagnosis, and management of drug-induced eosinophilia."4.98Drug-induced eosinophilia. ( Freeman, A; Rauscher, C, 2018)
" Of 2 treatment trials meeting inclusion criteria, 1 large trial (n = 3350) showed that low-dose aspirin did not prevent CVD events in persons with a screen-detected low ABI but may have increased the risk for major bleeding events."4.89The ankle-brachial index for peripheral artery disease screening and cardiovascular disease prediction among asymptomatic adults: a systematic evidence review for the U.S. Preventive Services Task Force. ( Johnson, ES; Lin, JS; Olson, CM; Whitlock, EP, 2013)
"In the peripheral arteries, a thrombus superimposed on atherosclerosis contributes to the progression of peripheral artery disease (PAD), producing intermittent claudication (IC), ischemic necrosis, and, potentially, loss of the limb."2.50Systematic reviews and meta-analyses for more profitable strategies in peripheral artery disease. ( Cafaro, G; de Gaetano, G; Di Minno, A; Di Minno, G; Lupoli, R; Petitto, M; Spadarella, G; Tremoli, E, 2014)
"Patients suffering from carotid artery stenosis symptomatic or not."2.48Carotid endarterectomy plus medical therapy or medical therapy alone for carotid artery stenosis in symptomatic or asymptomatic patients: a meta-analysis. ( Guay, J; Ochroch, EA, 2012)
"Orchitis is characterized by acute or chronic testicular inflammation and is a primary cause of male infertility."1.62Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice ( Chen, X; Ding, W; Jin, L; Lai, R; Liu, Y; Mwangi, J; Qiu, H; Zhao, L; Zhu, T, 2021)
"It is a marker of atherosclerotic plaque burden and the strongest independent predictor of future myocardial infarction and mortality."1.46Cardiac Society of Australia and New Zealand position statement executive summary: coronary artery calcium scoring. ( Chan, J; Chow, CK; Hamilton-Craig, CR; Jelinek, VM; Liew, GY; Younger, JF, 2017)
"All the patients presented with carotid artery stenosis >70% (North American Symptomatic Carotid Endarterectomy Trial [NASCET] criteria), which was symptomatic in 42 patients (transient ischemic attack, n = 32; minor stroke, n = 10) and asymptomatic in 146."1.46Dual Antiplatelet Therapy Does Not Increase the Risk of Bleeding After Carotid Endarterectomy: Results of a Prospective Study. ( Calio', FG; Illuminati, G; Masci, F; Pizzardi, G; Ricco, JB; Schneider, F, 2017)
"Aspirin resistance was measured by the PFA-100 system (collagen/epinephrine cartridge) and glycoprotein IIIa P1A1/A2 polymorphism was determined by PCR."1.43Aspirin resistance in cerebrovascular disease and the role of glycoprotein IIIa polymorphism in Turkish stroke patients. ( Ataç, BF; Bayraktar, N; Can, U; Çelikkol, C; Derle, E; Kibaroğlu, S; Öcal, R; Verdi, H, 2016)
"In the Asymptomatic Carotid Artery Stenosis trial (1995), medical management was defined as aspirin in addition to adequate control of comorbidities."1.39Efficacy of contemporary medical management for asymptomatic carotid artery stenosis. ( Ahn, JE; Chang, J; Chun, L; Landsman, N; Patel, KK; Rhee, K, 2013)
"Aspirin is a widely used medication for primary and secondary prevention of cardiovascular and cerebrovascular events."1.39The prevalence of gastroduodenal mucosal injuries in aspirin users. ( Thongbai, T, 2013)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (3.45)29.6817
2010's25 (86.21)24.3611
2020's3 (10.34)2.80

Authors

AuthorsStudies
Zhu, T1
Chen, X1
Qiu, H1
Liu, Y1
Mwangi, J1
Zhao, L1
Ding, W1
Lai, R1
Jin, L1
Chang, CC1
Spitzer, E1
Chichareon, P1
Takahashi, K1
Modolo, R1
Kogame, N1
Tomaniak, M1
Komiyama, H1
Yap, SC1
Hoole, SP1
Gori, T1
Zaman, A1
Frey, B1
Ferreira, RC1
Bertrand, OF1
Koh, TH1
Sousa, A1
Moschovitis, A1
van Geuns, RJ1
Steg, PG1
Hamm, C1
Jüni, P1
Vranckx, P1
Valgimigli, M1
Windecker, S1
Serruys, PW1
Soliman, O1
Onuma, Y1
Russo, LM1
Whitcomb, BW1
Freeman, JR1
Mumford, SL1
Sjaarda, LA1
Perkins, NJ1
Schliep, KC1
Grewal, J1
Silver, RM1
Schisterman, EF1
Hamilton-Craig, CR1
Chow, CK1
Younger, JF1
Jelinek, VM1
Chan, J1
Liew, GY1
Rauscher, C1
Freeman, A1
Guirguis-Blake, JM1
Evans, CV1
Redmond, N1
Lin, JS2
Curry, SJ1
Krist, AH1
Owens, DK1
Barry, MJ1
Caughey, AB1
Davidson, KW1
Doubeni, CA1
Epling, JW1
Kemper, AR1
Kubik, M1
Landefeld, CS1
Mangione, CM1
Silverstein, M1
Simon, MA1
Tseng, CW1
Wong, JB1
Murphy, SJX1
Naylor, AR1
Ricco, JB2
Sillesen, H1
Kakkos, S1
Halliday, A1
de Borst, GJ1
Vega de Ceniga, M1
Hamilton, G1
McCabe, DJH1
de Havenon, A1
Meyer, C1
McNally, JS1
Alexander, M1
Chung, L1
Conrad, MF3
Boulom, V1
Baloum, V1
Mukhopadhyay, S1
Garg, A1
Patel, VI2
Cambria, RP2
Olson, CM1
Johnson, ES1
Whitlock, EP1
Moyer, VA1
Chang, J1
Ahn, JE1
Landsman, N1
Rhee, K1
Chun, L1
Patel, KK1
Bakri, SJ1
Luqman, A1
Pathik, B1
Chandrasekaran, K1
Thongbai, T1
Alcocer, F1
Novak, Z1
Combs, BR1
Lowman, B1
Passman, MA1
Mujib, M1
Jordan, WD1
Michalczyk, MJ1
Opalacz, A1
LaMuraglia, GM1
Di Minno, G2
Spadarella, G1
Cafaro, G1
Petitto, M1
Lupoli, R1
Di Minno, A1
de Gaetano, G1
Tremoli, E1
Argulian, E1
Conen, D1
Messerli, FH1
Derle, E1
Öcal, R1
Kibaroğlu, S1
Çelikkol, C1
Bayraktar, N1
Verdi, H1
Ataç, BF1
Can, U1
Jones, DW1
Goodney, PP1
Nolan, BW1
Rzucidlo, EM1
Powell, RJ1
Cronenwett, JL1
Stone, DH1
Illuminati, G1
Schneider, F1
Pizzardi, G1
Masci, F1
Calio', FG1
Shankarappa, RK1
Panneerselvam, A1
Dwarakaprasad, R1
Karur, S1
Krishnanaik, GB1
Nanjappa, MC1
Tufano, A1
Guida, A1
Cerbone, AM1
Eborall, HC1
Stewart, MC1
Cunningham-Burley, S1
Price, JF1
Fowkes, FG1
Guay, J1
Ochroch, EA1
Dua, V1
Yadav, SP1
Kumar, V1
Saxena, R1
Sachdeva, A1
Spence, JD1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of Aspirin in Gestation and Reproduction: A Multi-center, Controlled, Double-blind Randomized Trial.[NCT00467363]1,228 participants (Actual)Interventional2007-06-30Completed
Health Program for prEvention of cardiovascuLar disEases Based on a Risk screeNing Strategy With Ankle-brachial Index.[NCT05884840]54,000 participants (Anticipated)Interventional2023-11-20Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Abruption

Partial or complete abruption (ie, premature separation of the placenta) (NCT00467363)
Timeframe: until delivery

Interventionparticipants (Number)
Aspirin7
Placebo5

Clinically Recognized Pregnancy

(NCT00467363)
Timeframe: 8-weeks

Interventionpregnancy (Number)
Aspirin374
Placebo346

Early Pregnancy Loss (EPL)

Implantation failures (NCT00467363)
Timeframe: 8 weeks

Interventionpregnancy (Number)
Aspirin28
Placebo27

Ectopic Pregnancy

(NCT00467363)
Timeframe: within 6 weeks

Interventionpregnancy (Number)
Aspirin3
Placebo3

Fetal Pregnancy Loss

(NCT00467363)
Timeframe: until 40 weeks

Interventionpregnancy (Number)
Aspirin4
Placebo6

hCG Recognized Pregnancy

(NCT00467363)
Timeframe: within 8-weeks of gestation

Interventionpregnancy (Number)
Aspirin394
Placebo363

Live Birth

Live birth was obtained prospectively by maternal report and abstraction from medical records by trained staff . (NCT00467363)
Timeframe: after delivery

Interventionlivebirths (Number)
Aspirin309
Placebo286

Molar Pregnancy

(NCT00467363)
Timeframe: 8 weeks

Interventionpregnancy (Number)
Aspirin0
Placebo0

Preeclampsia

(NCT00467363)
Timeframe: until delivery

Interventionparticipants (Number)
Aspirin32
Placebo30

Pregnancy Losses Occurring Less Than 10 Weeks

Includes preembryonic and embryonic losses (exclusive of implantation failures) (NCT00467363)
Timeframe: less than 10-weeks

Interventionpregnancy (Number)
Aspirin56
Placebo53

Preterm Birth

(NCT00467363)
Timeframe: until delivery

Interventioninfants (Number)
Aspirin22
Placebo31

Small for Gestational Age Infant

birthweight (NCT00467363)
Timeframe: until delivery

Interventiongrams (Mean)
Aspirin3327
Placebo3315

Stillbirth

(NCT00467363)
Timeframe: 40 weeks

Interventionparticipants (Number)
Aspirin2
Placebo2

Reviews

8 reviews available for aspirin and Asymptomatic Conditions

ArticleYear
Drug-induced eosinophilia.
    Allergy and asthma proceedings, 2018, May-01, Volume: 39, Issue:3

    Topics: Adult; Allergens; Aspirin; Asymptomatic Diseases; Cardiomyopathies; Drug Hypersensitivity; Eosinophi

2018
Screening for Peripheral Artery Disease Using the Ankle-Brachial Index: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
    JAMA, 2018, 07-10, Volume: 320, Issue:2

    Topics: Ankle Brachial Index; Aspirin; Asymptomatic Diseases; Early Diagnosis; Exercise Therapy; Fibrinolyti

2018
Optimal Antiplatelet Therapy in Moderate to Severe Asymptomatic and Symptomatic Carotid Stenosis: A Comprehensive Review of the Literature.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2019, Volume: 57, Issue:2

    Topics: Aspirin; Asymptomatic Diseases; Carotid Stenosis; Clopidogrel; Dipyridamole; Drug Therapy, Combinati

2019
Subclinical Cerebrovascular Disease: Epidemiology and Treatment.
    Current atherosclerosis reports, 2019, 07-27, Volume: 21, Issue:10

    Topics: Aged; Aged, 80 and over; Aspirin; Asymptomatic Diseases; Brain Infarction; Dementia; Female; Humans;

2019
The ankle-brachial index for peripheral artery disease screening and cardiovascular disease prediction among asymptomatic adults: a systematic evidence review for the U.S. Preventive Services Task Force.
    Annals of internal medicine, 2013, Sep-03, Volume: 159, Issue:5

    Topics: Adult; Ankle Brachial Index; Aspirin; Asymptomatic Diseases; Cardiovascular Diseases; Fibrinolytic A

2013
Systematic reviews and meta-analyses for more profitable strategies in peripheral artery disease.
    Annals of medicine, 2014, Volume: 46, Issue:7

    Topics: Adenosine; Aspirin; Asymptomatic Diseases; Cilostazol; Clopidogrel; Fibrinolytic Agents; Humans; Int

2014
Misconceptions and Facts About Atrial Fibrillation.
    The American journal of medicine, 2015, Volume: 128, Issue:9

    Topics: Administration, Oral; Alcohol Drinking; Anticoagulants; Aspirin; Asymptomatic Diseases; Atrial Fibri

2015
Carotid endarterectomy plus medical therapy or medical therapy alone for carotid artery stenosis in symptomatic or asymptomatic patients: a meta-analysis.
    Journal of cardiothoracic and vascular anesthesia, 2012, Volume: 26, Issue:5

    Topics: Aspirin; Asymptomatic Diseases; Carotid Stenosis; Endarterectomy, Carotid; Humans; Life Style; Rando

2012

Trials

3 trials available for aspirin and Asymptomatic Conditions

ArticleYear
Ascertainment of Silent Myocardial Infarction in Patients Undergoing Percutaneous Coronary Intervention (from the GLOBAL LEADERS Trial).
    The American journal of cardiology, 2019, 12-15, Volume: 124, Issue:12

    Topics: Aged; Analysis of Variance; Aspirin; Asymptomatic Diseases; Coronary Angiography; Drug Therapy, Comb

2019
Physical activity and incidence of subclinical and clinical pregnancy loss: a secondary analysis in the effects of aspirin in gestation and reproduction randomized trial.
    Fertility and sterility, 2020, Volume: 113, Issue:3

    Topics: Abortion, Spontaneous; Adolescent; Adult; Aspirin; Asymptomatic Diseases; Cohort Studies; Exercise;

2020
Accrual and drop out in a primary prevention randomised controlled trial: qualitative study.
    Trials, 2011, Jan-11, Volume: 12

    Topics: Aged; Aspirin; Asymptomatic Diseases; Atherosclerosis; Cardiovascular Agents; Female; Focus Groups;

2011

Other Studies

18 other studies available for aspirin and Asymptomatic Conditions

ArticleYear
Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice
    Frontiers in immunology, 2021, Volume: 12

    Topics: Acetylation; Air Pollutants; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asymptomatic

2021
Screening for Asymptomatic Carotid Artery Stenosis: Recommendation Statement.
    American family physician, 2021, 05-15, Volume: 103, Issue:10

    Topics: Aged; Aspirin; Asymptomatic Diseases; Cardiovascular Diseases; Carotid Stenosis; Health Behavior; He

2021
Cardiac Society of Australia and New Zealand position statement executive summary: coronary artery calcium scoring.
    The Medical journal of Australia, 2017, Oct-16, Volume: 207, Issue:8

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asymptomatic Diseases; Coronary Artery Disea

2017
Screening for Peripheral Artery Disease and Cardiovascular Disease Risk Assessment With the Ankle-Brachial Index: US Preventive Services Task Force Recommendation Statement.
    JAMA, 2018, 07-10, Volume: 320, Issue:2

    Topics: Adult; Ankle Brachial Index; Aspirin; Asymptomatic Diseases; Early Diagnosis; Exercise Therapy; Fibr

2018
Progression of asymptomatic carotid stenosis despite optimal medical therapy.
    Journal of vascular surgery, 2013, Volume: 58, Issue:1

    Topics: Aged; Aged, 80 and over; Aspirin; Asymptomatic Diseases; Biomarkers; Cardiovascular Agents; Carotid

2013
Screening for peripheral artery disease and cardiovascular disease risk assessment with the ankle-brachial index in adults: U.S. Preventive Services Task Force recommendation statement.
    Annals of internal medicine, 2013, Sep-03, Volume: 159, Issue:5

    Topics: Adult; Ankle Brachial Index; Aspirin; Asymptomatic Diseases; Cardiovascular Diseases; Cost of Illnes

2013
Efficacy of contemporary medical management for asymptomatic carotid artery stenosis.
    The American surgeon, 2013, Volume: 79, Issue:10

    Topics: Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors;

2013
Is carotid ultrasound necessary in the evaluation of the asymptomatic Hollenhorst plaque?
    Ophthalmology, 2013, Volume: 120, Issue:12

    Topics: Arterioles; Aspirin; Asymptomatic Diseases; Carotid Arteries; Carotid Stenosis; Endarterectomy, Caro

2013
The prevalence of gastroduodenal mucosal injuries in aspirin users.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2013, Volume: 96, Issue:11

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asymptomatic Diseases; Endoscopy, Gastrointe

2013
Dual antiplatelet therapy (clopidogrel and aspirin) is associated with increased all-cause mortality after carotid revascularization for asymptomatic carotid disease.
    Journal of vascular surgery, 2014, Volume: 59, Issue:4

    Topics: Aged; Alabama; Angioplasty; Aspirin; Asymptomatic Diseases; Carotid Stenosis; Clopidogrel; Drug Ther

2014
The natural history of asymptomatic severe carotid artery stenosis.
    Journal of vascular surgery, 2014, Volume: 60, Issue:5

    Topics: Aged; Aspirin; Asymptomatic Diseases; Blood Flow Velocity; Cardiovascular Agents; Carotid Stenosis;

2014
Aspirin resistance in cerebrovascular disease and the role of glycoprotein IIIa polymorphism in Turkish stroke patients.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2016, Volume: 27, Issue:2

    Topics: Age Factors; Aged; Aged, 80 and over; Aspirin; Asymptomatic Diseases; Blood Platelets; Drug Resistan

2016
Dual antiplatelet therapy reduces stroke but increases bleeding at the time of carotid endarterectomy.
    Journal of vascular surgery, 2016, Volume: 63, Issue:5

    Topics: Aged; Aspirin; Asymptomatic Diseases; Carotid Artery Diseases; Chi-Square Distribution; Clopidogrel;

2016
Dual Antiplatelet Therapy Does Not Increase the Risk of Bleeding After Carotid Endarterectomy: Results of a Prospective Study.
    Annals of vascular surgery, 2017, Volume: 40

    Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Asymptomatic Diseases; Carotid Stenosis; Clopidogr

2017
Spontaneous asymptomatic coronary artery dissection in a young man.
    Journal of cardiology, 2009, Volume: 54, Issue:3

    Topics: Acute Coronary Syndrome; Adult; Age Factors; Aortic Dissection; Aspirin; Asymptomatic Diseases; Coro

2009
The "antiphospholipid triangle" in an asymptomatic patient: a case report.
    Internal and emergency medicine, 2010, Volume: 5, Issue:5

    Topics: Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Aspirin; Asymptomatic Diseases; beta 2-Glyco

2010
Two cases of pediatric essential thrombocythemia managed effectively with hydroxyurea.
    International journal of hematology, 2012, Volume: 96, Issue:6

    Topics: Aspirin; Asymptomatic Diseases; Bone Marrow; Child; Child, Preschool; Female; Headache; Humans; Hydr

2012
Asymptomatic carotid stenosis.
    Circulation, 2013, Feb-12, Volume: 127, Issue:6

    Topics: Aged; Amlodipine; Anticholesteremic Agents; Aspirin; Asymptomatic Diseases; Atorvastatin; Azetidines

2013