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aspirin and Asymmetric Diabetic Proximal Motor Neuropathy

aspirin has been researched along with Asymmetric Diabetic Proximal Motor Neuropathy in 15 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"Morphine is a drug used in chronic pain such as diabetic neuropathy, but the development of tolerance to its antinociceptive effect is an important clinical problem."4.31Aspirin attenuates morphine antinociceptive tolerance in rats with diabetic neuropathy by inhibiting apoptosis in the dorsal root ganglia. ( Avcı, O; Gunes, H; Gursoy, S; Inan, ZDS; Ozdemir, E; Taskiran, AS, 2023)
"In at-risk patients with type 2 diabetes, intensive intervention with multiple drug combinations and behavior modification had sustained beneficial effects with respect to vascular complications and on rates of death from any cause and from cardiovascular causes."2.73Effect of a multifactorial intervention on mortality in type 2 diabetes. ( Gaede, P; Lund-Andersen, H; Parving, HH; Pedersen, O, 2008)
"Pentosidine levels were significantly correlated with severity of retinopathy and neuropathy, but not nephropathy."2.68Effects of aspirin or basic amino acids on collagen cross-links and complications in NIDDM. ( Blanco, MC; Camejo, M; Contreras, I; Giansante, E; Gonzalez, F; Lopez, T; Martinez, N; Molina, M; Postalian, S; Reiser, KM; Sanchez, MR; Suarez, N, 1997)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.67)18.7374
1990's7 (46.67)18.2507
2000's2 (13.33)29.6817
2010's4 (26.67)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Ozdemir, E1
Avcı, O1
Inan, ZDS1
Taskiran, AS1
Gunes, H1
Gursoy, S1
Cerit, L1
Duygu, H1
Bhatt, DL1
Grosser, T1
Dong, JF1
Logan, D1
Jeske, W1
Angiolillo, DJ1
Frelinger, AL1
Liang, J1
Cryer, B1
Marathi, U1
Micov, A1
Tomić, M1
Pecikoza, U1
Ugrešić, N1
Stepanović-Petrović, R1
Bhatt, LK1
Veeranjaneyulu, A1
Brown, AF1
Mangione, CM1
Saliba, D1
Sarkisian, CA1
Gaede, P1
Lund-Andersen, H1
Parving, HH1
Pedersen, O1
Courteix, C1
Bardin, M1
Chantelauze, C1
Lavarenne, J1
Eschalier, A1
Homberg, M1
Tschöpe, D1
Greber, H1
Hackländer, T1
Schwippert, B1
Gries, FA1
Mödder, U1
Julu, PO1
Gow, JW1
Jamal, GA1
Husstedt, IW1
Grotemeyer, KH1
Evers, S1
Staschewski, F1
Wertelewski, R1
Contreras, I1
Reiser, KM1
Martinez, N1
Giansante, E1
Lopez, T1
Suarez, N1
Postalian, S1
Molina, M1
Gonzalez, F1
Sanchez, MR1
Camejo, M1
Blanco, MC1
Davis, MD1
Fisher, MR1
Gangnon, RE1
Barton, F1
Aiello, LM1
Chew, EY1
Ferris, FL1
Knatterud, GL1
Kwaan, HC1
Colwell, JA1
Cruz, S1
Suwanwela, N1
Dobbie, JG1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Identifying and Overcoming Barriers to Diabetes Management in the Elderly: An Intervention Study[NCT01480804]48 participants (Actual)Interventional2006-11-30Completed
Identifying and Overcoming Barriers to Diabetes Management in the Elderly: A Cost-effective Intervention Study[NCT01486290]52 participants (Actual)Interventional2007-07-31Completed
The Impact of Novel Strategies to Improve Cardiometabolic Status and Adherence to Exercise Regimens in Patients at High Risk for Cardiovascular Disease[NCT03103854]500 participants (Anticipated)Interventional2014-01-01Recruiting
Intensified Multifactorial Intervention in Patients With Type 2 Diabetes and Microalbuminuria[NCT00320008]160 participants (Actual)Interventional1992-01-31Active, not recruiting
A Randomised Controlled Trial of a Duodenal Sleeve Bypass Device (EndoBarrier)Compared With Standard Medical Therapy for the Management of Obese Subjects With Type 2 Diabetes[NCT02459561]170 participants (Actual)Interventional2015-03-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for aspirin and Asymmetric Diabetic Proximal Motor Neuropathy

ArticleYear
Effect of a multifactorial intervention on mortality in type 2 diabetes.
    The New England journal of medicine, 2008, Feb-07, Volume: 358, Issue:6

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Behavior Therapy; Cardiovascular Diseases;

2008
Effect of a multifactorial intervention on mortality in type 2 diabetes.
    The New England journal of medicine, 2008, Feb-07, Volume: 358, Issue:6

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Behavior Therapy; Cardiovascular Diseases;

2008
Effect of a multifactorial intervention on mortality in type 2 diabetes.
    The New England journal of medicine, 2008, Feb-07, Volume: 358, Issue:6

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Behavior Therapy; Cardiovascular Diseases;

2008
Effect of a multifactorial intervention on mortality in type 2 diabetes.
    The New England journal of medicine, 2008, Feb-07, Volume: 358, Issue:6

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Behavior Therapy; Cardiovascular Diseases;

2008
Effect of a multifactorial intervention on mortality in type 2 diabetes.
    The New England journal of medicine, 2008, Feb-07, Volume: 358, Issue:6

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Behavior Therapy; Cardiovascular Diseases;

2008
Effect of a multifactorial intervention on mortality in type 2 diabetes.
    The New England journal of medicine, 2008, Feb-07, Volume: 358, Issue:6

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Behavior Therapy; Cardiovascular Diseases;

2008
Effect of a multifactorial intervention on mortality in type 2 diabetes.
    The New England journal of medicine, 2008, Feb-07, Volume: 358, Issue:6

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Behavior Therapy; Cardiovascular Diseases;

2008
Effect of a multifactorial intervention on mortality in type 2 diabetes.
    The New England journal of medicine, 2008, Feb-07, Volume: 358, Issue:6

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Behavior Therapy; Cardiovascular Diseases;

2008
Effect of a multifactorial intervention on mortality in type 2 diabetes.
    The New England journal of medicine, 2008, Feb-07, Volume: 358, Issue:6

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Behavior Therapy; Cardiovascular Diseases;

2008
Effects of aspirin or basic amino acids on collagen cross-links and complications in NIDDM.
    Diabetes care, 1997, Volume: 20, Issue:5

    Topics: Analysis of Variance; Arginine; Aspirin; Biopsy; Blood Glucose; Collagen; Cross-Linking Reagents; Cy

1997
Risk factors for high-risk proliferative diabetic retinopathy and severe visual loss: Early Treatment Diabetic Retinopathy Study Report #18.
    Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:2

    Topics: Adolescent; Adult; Aged; Aspirin; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neu

1998

Other Studies

12 other studies available for aspirin and Asymmetric Diabetic Proximal Motor Neuropathy

ArticleYear
Aspirin attenuates morphine antinociceptive tolerance in rats with diabetic neuropathy by inhibiting apoptosis in the dorsal root ganglia.
    Metabolic brain disease, 2023, Volume: 38, Issue:6

    Topics: Analgesics; Animals; Apoptosis; Aspirin; bcl-2-Associated X Protein; Caspase 3; Diabetes Mellitus, E

2023
Collapse of the Aspirin Empire: Is it Diabetic Gastroparesis or Cardioprotective Paresis?
    Journal of the American College of Cardiology, 2017, 06-13, Volume: 69, Issue:23

    Topics: Aspirin; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Gastroparesis; Humans; Paresis

2017
Reply: Collapse of the Aspirin Empire: Is it Diabetic Gastroparesis or Cardioprotective Paresis?
    Journal of the American College of Cardiology, 2017, 06-13, Volume: 69, Issue:23

    Topics: Aspirin; Diabetic Neuropathies; Gastroparesis; Humans; Paresis

2017
Levetiracetam synergises with common analgesics in producing antinociception in a mouse model of painful diabetic neuropathy.
    Pharmacological research, 2015, Volume: 97

    Topics: Acetaminophen; Analgesics; Animals; Aspirin; Diabetic Neuropathies; Dose-Response Relationship, Drug

2015
Minocycline with aspirin: a therapeutic approach in the treatment of diabetic neuropathy.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2010, Volume: 31, Issue:6

    Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diabetic Neuropathies;

2010
Guidelines for improving the care of the older person with diabetes mellitus.
    Journal of the American Geriatrics Society, 2003, Volume: 51, Issue:5 Suppl Gu

    Topics: Accidental Falls; Aged; Aspirin; Cognition Disorders; Depression; Diabetes Complications; Diabetes M

2003
Guidelines for improving the care of the older person with diabetes mellitus.
    Journal of the American Geriatrics Society, 2003, Volume: 51, Issue:5 Suppl Gu

    Topics: Accidental Falls; Aged; Aspirin; Cognition Disorders; Depression; Diabetes Complications; Diabetes M

2003
Guidelines for improving the care of the older person with diabetes mellitus.
    Journal of the American Geriatrics Society, 2003, Volume: 51, Issue:5 Suppl Gu

    Topics: Accidental Falls; Aged; Aspirin; Cognition Disorders; Depression; Diabetes Complications; Diabetes M

2003
Guidelines for improving the care of the older person with diabetes mellitus.
    Journal of the American Geriatrics Society, 2003, Volume: 51, Issue:5 Suppl Gu

    Topics: Accidental Falls; Aged; Aspirin; Cognition Disorders; Depression; Diabetes Complications; Diabetes M

2003
Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics.
    Pain, 1994, Volume: 57, Issue:2

    Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Aspirin; Clonidine; Diabetes Mellitus, Experi

1994
[Optic neuropathy in type-1 diabetes and acetylsalicylic acid-refractory thrombocyte activation].
    Deutsche medizinische Wochenschrift (1946), 1993, Mar-05, Volume: 118, Issue:9

    Topics: Adult; Aspirin; Chronic Disease; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diabetic Neuropa

1993
Endogenous cyclo-oxygenase substrates mediate the neuroactivity of evening primrose oil in rats.
    Journal of lipid mediators and cell signalling, 1996, Volume: 13, Issue:2

    Topics: Animals; Aspirin; Blood Glucose; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diabeti

1996
Progression of distal symmetric polyneuropathy during diabetes mellitus: clinical, neurophysiological, haemorheological changes and self-rating scales of patients.
    European neurology, 1997, Volume: 37, Issue:2

    Topics: Adolescent; Adult; Aged; Aspirin; Blood Glucose; Blood Viscosity; Diabetes Mellitus, Type 1; Diabete

1997
Drugs for pain.
    The Medical letter on drugs and therapeutics, 1998, Aug-14, Volume: 40, Issue:1033

    Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics

1998
Increased platelet aggregation in diabetes mellitus.
    The Journal of laboratory and clinical medicine, 1972, Volume: 80, Issue:2

    Topics: Adenosine Diphosphate; Aspirin; Blood Chemical Analysis; Blood Proteins; Creatinine; Diabetes Mellit

1972