aspirin and Arterial Brain Diseases studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

Excerpt	Relevance	Reference
"The Fraxiparin in Stroke Study for the treatment of ischemic stroke (FISS-tris) study showed no superiority of low-molecular-weight heparin (LMWH) over aspirin for the primary end point (Barthel Index) in acute ischemic stroke due to large artery occlusive disease."	9.16	Low-molecular-weight heparin versus aspirin for acute ischemic stroke with large artery occlusive disease: subgroup analyses from the Fraxiparin in Stroke Study for the treatment of ischemic stroke (FISS-tris) study. ( Chen, C; Chen, XY; Han, JH; Leung, TW; Mok, V; Soo, Y; Wang, QS; Wong, KS, 2012)
" The effects of cilostazol and aspirin on ischemic stroke prevention and treatment were almost equal (combined odds ratio (OR) 0."	8.89	Systematic study of cilostazol on secondary stroke prevention: a meta-analysis. ( Bi, Q; Qian, Y, 2013)
"Accordingly, 50 mg clopidogrel plus aspirin, and 75 mg clopidogrel plus aspirin were all superior to aspirin alone as stroke prevention in patients with cerebral infarction or transient ischemic attack combined with intracranial and extracranial arteriostenosis."	5.24	The effectiveness and safety of dual antiplatelet therapy in ischemic cerebrovascular disease with intracranial and extracranial arteriostenosis in Chinese patients: A randomized and controlled trail. ( Dong, AQ; Liu, H; Liu, JQ; Su, N; Wu, HJ; Zuo, FT, 2017)
"The Fraxiparin in Stroke Study for the treatment of ischemic stroke (FISS-tris) study showed no superiority of low-molecular-weight heparin (LMWH) over aspirin for the primary end point (Barthel Index) in acute ischemic stroke due to large artery occlusive disease."	5.16	Low-molecular-weight heparin versus aspirin for acute ischemic stroke with large artery occlusive disease: subgroup analyses from the Fraxiparin in Stroke Study for the treatment of ischemic stroke (FISS-tris) study. ( Chen, C; Chen, XY; Han, JH; Leung, TW; Mok, V; Soo, Y; Wang, QS; Wong, KS, 2012)
" The effects of cilostazol and aspirin on ischemic stroke prevention and treatment were almost equal (combined odds ratio (OR) 0."	4.89	Systematic study of cilostazol on secondary stroke prevention: a meta-analysis. ( Bi, Q; Qian, Y, 2013)
"Location of stenosis, type of qualifying event, and prior use of antithrombotic medications were not associated with increased risk."	2.72	Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis. ( Benesch, CG; Chaturvedi, S; Chimowitz, MI; Cloft, HJ; Frankel, MR; Hertzberg, VS; Howlett-Smith, H; Jovin, TG; Kasner, SE; Levine, SR; Lynn, MJ; Romano, JG; Sila, CA; Stern, BJ, 2006)
"Losartan is known to inhibit transforming growth factor β signaling and may be a specific modulator of disease expression in this syndrome."	1.37	Arterial tortuosity syndrome with multiple intracranial aneurysms: a case report. ( Levinson, JR; MacRae, CA; Nahed, BV; Naunheim, MR; Ogilvy, CS; Walcott, BP, 2011)

Research

Studies (11)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Cumulative Morbidity and Mortality Rate (Ischemic Event, Parenchymal Brain Hemorrhage, Subarachnoid or Intraventricular Hemorrhage or Death)

Cumulative Stroke Rate at 12 Months

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (27.27)	29.6817
2010's	8 (72.73)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Li, X	1
Zhao, K	1
Ma, N	1
Sun, S	1
Miao, Z	1
Zhao, Z	1
Li, J	1
Wang, A	2
Zhao, X	2
Liu, L	2
Meng, X	2
Lin, J	1
Jing, J	2
Zou, X	2
Wang, Y	4
Qian, Y	1
Bi, Q	1
Wong, KS	2
Leng, X	1
Pu, Y	1
Pan, Y	1
Wang, C	1
Soo, Y	2
Johnston, SC	1
Zuo, FT	1
Liu, H	1
Wu, HJ	1
Su, N	1
Liu, JQ	1
Dong, AQ	1
Naunheim, MR	1
Walcott, BP	1
Nahed, BV	1
MacRae, CA	1
Levinson, JR	1
Ogilvy, CS	1
Bang, OY	1
Kim, JS	1
Wang, QS	1
Chen, C	1
Chen, XY	1
Han, JH	1
Leung, TW	1
Mok, V	1
Gere, J	1
Minier, D	1
Osseby, GV	1
Couvreur, G	1
Moreau, T	1
Giroud, M	1
Kasner, SE	1
Chimowitz, MI	2
Lynn, MJ	2
Howlett-Smith, H	1
Stern, BJ	1
Hertzberg, VS	1
Frankel, MR	1
Levine, SR	1
Chaturvedi, S	1
Benesch, CG	1
Sila, CA	1
Jovin, TG	1
Romano, JG	1
Cloft, HJ	1
Williams, JE	1
Cotsonis, GA	1
Waddy, SP	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Randomized,Double-blind Trial Comparing the Effects of a 3-month Clopidogrel Regimen,Combined With ASA During the First 21days,Versus ASA Alone for the Acute Treatment of TIA or Minor Stroke[NCT00979589]	Phase 3	5,100 participants (Actual)	Interventional	2009-12-31	Completed
Implantation of CERENOVUS ENTERPRISE 2 Intracranial Stent in Patients With Severe Symptomatic Intracranial Atherosclerotic Stenosis: A Multicenter, Prospective and Single-Arm Study in China[NCT05316311]		194 participants (Anticipated)	Interventional	2022-05-24	Recruiting
An International Registry of the Wingspan™ Stent System for the Treatment of Intracranial Atherosclerotic Stenosis[NCT00929383]		82 participants (Actual)	Observational	2009-02-28	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	participants (Number)
Patients Treated With a Wingspan Stent	12

The cumulative stroke rate at 12 months (any stroke or neurological death /= 31 days is 15.9% or 13 events per 82 patients (NCT00929383)
Timeframe: 12 months

Rate of Recurrent Ischemic Stroke in the Target Territory

Intervention	participants (Number)
Patients Treated With a Wingspan Stent	13

The rate of recurrent ischemic stroke from 31 days to 12 months post procedure was 1.3% or 1 event per 77 patients analyzed. (NCT00929383)
Timeframe: 12 Months

Rate of Restenosis

Intervention	participants (Number)
Patients Treated With a Wingspan Stent	1

"The rate of restenosis at 12 months was defined as the degree of residual stenosis greater than 50% as determined by the study sites using the WASID method. There was a 10.4% rate of restenosis >50% or 8 patients out of 77 analyzed. The differences in this analysis population N=77 vs. ITT N= 82 populations results from exclusion of N=4 patients with no stent implanted and N=1 patient who died prior to any follow up measures of restenosis.~The WASID method is a standardized protocol for measuring intracranial arterial stenosis.~[1-(Dstenosis/Dnormal)] x100=% stenosis (where D=vessel diameter)" (NCT00929383)
Timeframe: 12 Months

Successful Wingspan™ Stent Implantation (Access to the Lesion With the Stent, Accurate Deployment of the Stent Across the Target Lesion)

Intervention	participants (Number)
Patients Treated With a Wingspan Stent	8

The number of Wingspan Stents successfully deployed across the target lesion. (NCT00929383)
Timeframe: Peri-procedural

Article	Year
Systematic study of cilostazol on secondary stroke prevention: a meta-analysis. European journal of medical research, 2013, Dec-06, Volume: 18 Topics: Aspirin; Brain Ischemia; Cilostazol; Clinical Trials as Topic; Disease Progression; Humans; Incidenc	2013
[Indications for anticoagulant use in secondary prevention of strokes]. Presse medicale (Paris, France : 1983), 2003, Jul-26, Volume: 32, Issue:25 Topics: Anticoagulants; Antiphospholipid Syndrome; Arteriosclerosis; Aspirin; Atrial Fibrillation; Cardiovas	2003

Article	Year
High-sensitive C-reactive protein and dual antiplatelet in intracranial arterial stenosis. Neurology, 2018, 02-06, Volume: 90, Issue:6 Topics: Aged; Aspirin; C-Reactive Protein; Clopidogrel; Constriction, Pathologic; Double-Blind Method; Drug	2018
Dual antiplatelet therapy in stroke and ICAS: Subgroup analysis of CHANCE. Neurology, 2015, Sep-29, Volume: 85, Issue:13 Topics: Aged; Aspirin; Clopidogrel; Constriction, Pathologic; Double-Blind Method; Drug Therapy, Combination	2015
The effectiveness and safety of dual antiplatelet therapy in ischemic cerebrovascular disease with intracranial and extracranial arteriostenosis in Chinese patients: A randomized and controlled trail. Medicine, 2017, Volume: 96, Issue:1 Topics: Arterial Occlusive Diseases; Aspirin; China; Clopidogrel; Dose-Response Relationship, Drug; Drug The	2017
Low-molecular-weight heparin versus aspirin for acute ischemic stroke with large artery occlusive disease: subgroup analyses from the Fraxiparin in Stroke Study for the treatment of ischemic stroke (FISS-tris) study. Stroke, 2012, Volume: 43, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Arterial Occlusive Diseases; As	2012
Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis. Circulation, 2006, Jan-31, Volume: 113, Issue:4 Topics: Aged; Anticoagulants; Aspirin; Brain Ischemia; Cerebrovascular Circulation; Constriction, Pathologic	2006
Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis. Circulation, 2006, Jan-31, Volume: 113, Issue:4 Topics: Aged; Anticoagulants; Aspirin; Brain Ischemia; Cerebrovascular Circulation; Constriction, Pathologic	2006
Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis. Circulation, 2006, Jan-31, Volume: 113, Issue:4 Topics: Aged; Anticoagulants; Aspirin; Brain Ischemia; Cerebrovascular Circulation; Constriction, Pathologic	2006
Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis. Circulation, 2006, Jan-31, Volume: 113, Issue:4 Topics: Aged; Anticoagulants; Aspirin; Brain Ischemia; Cerebrovascular Circulation; Constriction, Pathologic	2006
Gender differences in outcomes among patients with symptomatic intracranial arterial stenosis. Stroke, 2007, Volume: 38, Issue:7 Topics: Aged; Anticoagulants; Aspirin; Constriction, Pathologic; Female; Humans; Intracranial Arterial Disea	2007

Article	Year
Association of ABCB1 promoter methylation with aspirin exposure, platelet function, and clinical outcomes in Chinese intracranial artery stenosis patients. European journal of clinical pharmacology, 2017, Volume: 73, Issue:10 Topics: Arterial Occlusive Diseases; Aspirin; ATP Binding Cassette Transporter, Subfamily B; Case-Control St	2017
Arterial tortuosity syndrome with multiple intracranial aneurysms: a case report. Archives of neurology, 2011, Volume: 68, Issue:3 Topics: Aged; Angiography; Antihypertensive Agents; Aorta; Aspirin; Circle of Willis; Connective Tissue Dise	2011
Low-molecular-weight heparin in atherosclerotic stroke: a surprising resurrection of anticoagulants? Stroke, 2012, Volume: 43, Issue:2 Topics: Antifibrinolytic Agents; Arterial Occlusive Diseases; Aspirin; Brain Ischemia; Female; Humans; Intra	2012

aspirin and Arterial Brain Diseases