aspirin and Anovulation studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Anovulation: Suspension or cessation of OVULATION in animals or humans with follicle-containing ovaries (OVARIAN FOLLICLE). Depending on the etiology, OVULATION may be induced with appropriate therapy.

Research Excerpts

Excerpt	Relevance	Reference
"Among women with a single, recent pregnancy loss, daily preconception low-dose aspirin (LDA) increased the live birth rate with no effect on pregnancy loss."	9.24	Low-Dose Aspirin and Sporadic Anovulation in the EAGeR Randomized Trial. ( Chen, Z; Galai, N; Lesher, LL; Mumford, SL; Perkins, NJ; Radin, RG; Schisterman, EF; Silver, RM; Sjaarda, LA; Wactawski-Wende, J, 2017)
"To evaluate the efficacy of co-administration of low-dose aspirin (LDA) and tamoxifen on ovulation rates, endometrial thickness and clinical pregnancy rates in anovulatory PCOS women."	5.30	A new look at low-dose aspirin: Co-administration with tamoxifen in ovulation induction in anovulatory PCOS women. ( Ahmed, MR; Ahmed, WAS; Aref, NK; Sedik, WF, 2019)
"Among women with a single, recent pregnancy loss, daily preconception low-dose aspirin (LDA) increased the live birth rate with no effect on pregnancy loss."	5.24	Low-Dose Aspirin and Sporadic Anovulation in the EAGeR Randomized Trial. ( Chen, Z; Galai, N; Lesher, LL; Mumford, SL; Perkins, NJ; Radin, RG; Schisterman, EF; Silver, RM; Sjaarda, LA; Wactawski-Wende, J, 2017)

Research

Studies (4)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Abruption

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	4 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Aref, NK	1
Ahmed, WAS	1
Ahmed, MR	1
Sedik, WF	1
Matyas, RA	1
Mumford, SL	2
Schliep, KC	1
Ahrens, KA	1
Sjaarda, LA	2
Perkins, NJ	2
Filiberto, AC	1
Mattison, D	1
Zarek, SM	1
Wactawski-Wende, J	2
Schisterman, EF	2
Radin, RG	1
Silver, RM	1
Chen, Z	1
Lesher, LL	1
Galai, N	1
Espín López, L	1
Carrillo Verdejo, E	1
González Javier, F	1
Ordoñana Martín, JR	1
Gómez-Amor, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Effects of Aspirin in Gestation and Reproduction: A Multi-center, Controlled, Double-blind Randomized Trial.[NCT00467363]		1,228 participants (Actual)	Interventional	2007-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Partial or complete abruption (ie, premature separation of the placenta) (NCT00467363)
Timeframe: until delivery

Clinically Recognized Pregnancy

Early Pregnancy Loss (EPL)

Ectopic Pregnancy

Fetal Pregnancy Loss

hCG Recognized Pregnancy

Live Birth

Intervention	participants (Number)
Aspirin	7
Placebo	5

Intervention	pregnancy (Number)
Aspirin	374
Placebo	346

Intervention	pregnancy (Number)
Aspirin	28
Placebo	27

Intervention	pregnancy (Number)
Aspirin	3
Placebo	3

Intervention	pregnancy (Number)
Aspirin	4
Placebo	6

Intervention	pregnancy (Number)
Aspirin	394
Placebo	363

Live birth was obtained prospectively by maternal report and abstraction from medical records by trained staff . (NCT00467363)
Timeframe: after delivery

Molar Pregnancy

Preeclampsia

Pregnancy Losses Occurring Less Than 10 Weeks

Intervention	livebirths (Number)
Aspirin	309
Placebo	286

Intervention	pregnancy (Number)
Aspirin	0
Placebo	0

Intervention	participants (Number)
Aspirin	32
Placebo	30

Includes preembryonic and embryonic losses (exclusive of implantation failures) (NCT00467363)
Timeframe: less than 10-weeks

Article	Year
A new look at low-dose aspirin: Co-administration with tamoxifen in ovulation induction in anovulatory PCOS women. Journal of gynecology obstetrics and human reproduction, 2019, Volume: 48, Issue:8 Topics: Adult; Anovulation; Aspirin; Dose-Response Relationship, Drug; Drug Therapy, Combination; Egypt; End	2019
Low-Dose Aspirin and Sporadic Anovulation in the EAGeR Randomized Trial. The Journal of clinical endocrinology and metabolism, 2017, 01-01, Volume: 102, Issue:1 Topics: Adolescent; Adult; Anovulation; Aspirin; Double-Blind Method; Female; Follow-Up Studies; Humans; Liv	2017

Article	Year
Effects of over-the-counter analgesic use on reproductive hormones and ovulation in healthy, premenopausal women. Human reproduction (Oxford, England), 2015, Volume: 30, Issue:7 Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anovulation; Aspirin; Female; Follicular	2015
Incidence of anovulatory menstrual cycles among dysmenorrheic and non-non-dysmenorrheic [corrected] women: effects on symptomatology and mood. Psicothema, 2010, Volume: 22, Issue:4 Topics: Adolescent; Affect; Amenorrhea; Anovulation; Aspirin; Body Temperature; Comorbidity; Dizziness; Dysm	2010

aspirin and Anovulation