aspirin has been researched along with Angiogenesis, Pathologic in 59 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion with that of aspirin." | 9.13 | Long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion. ( Farahvash, MM; Farahvash, MS; Mohammadzadeh, S; Moradimogadam, M, 2008) |
| "VEGF and endostatin concentrations were measured with a quantitative immunoassay before and after 1 to 5 weeks of treatment in 30 women with breast cancer treated with either tamoxifen (n = 14) or aromatase inhibitors (n = 16)." | 9.13 | Tamoxifen and aromatase inhibitors differentially affect vascular endothelial growth factor and endostatin levels in women with breast cancer. ( Holmes, CE; Howard, AB; Huang, JC; Muss, HB; Pace, TR, 2008) |
| "Rosacea is a chronic, relapsing inflammatory skin disease featured by abnormal activation of immune responses, vascular dysfunction and prominent permeability barrier alterations." | 5.62 | Aspirin alleviates skin inflammation and angiogenesis in rosacea. ( Chen, M; Deng, Z; Li, J; Liu, T; Peng, Q; Sha, K; Wang, B; Xiao, W; Xie, H; Xu, S; Zhang, Y, 2021) |
| "Stroke is the major cause of death and decrease in the activities of daily living." | 5.40 | Neurovascular protection of cilostazol in stroke-prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation. ( Abe, K; Deguchi, K; Ikeda, Y; Kono, S; Kurata, T; Liu, N; Liu, W; Omote, Y; Yamashita, T, 2014) |
| "Rheumatoid arthritis is a chronic inflammatory disease characterized by overproduction of inflammatory mediators along with undermined oxidative defensive mechanisms." | 5.40 | Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. ( El-Azab, MF; El-Sayed, RM; Moustafa, YM, 2014) |
| "Aspirin resistance was defined when epinephrine closure time <174 s." | 5.34 | Prevalence and biologic profile of aspirin resistance in patients with angiographically proven coronary artery disease. ( de Lafuente, JP; Iriarte, JA; Lafita, M; Molinero, E; Monica, S; Narvaez, I; Saez, Y; Sagastagoitia, JD; Vacas, M, 2007) |
| "To compare the long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion with that of aspirin." | 5.13 | Long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion. ( Farahvash, MM; Farahvash, MS; Mohammadzadeh, S; Moradimogadam, M, 2008) |
| "VEGF and endostatin concentrations were measured with a quantitative immunoassay before and after 1 to 5 weeks of treatment in 30 women with breast cancer treated with either tamoxifen (n = 14) or aromatase inhibitors (n = 16)." | 5.13 | Tamoxifen and aromatase inhibitors differentially affect vascular endothelial growth factor and endostatin levels in women with breast cancer. ( Holmes, CE; Howard, AB; Huang, JC; Muss, HB; Pace, TR, 2008) |
| "Although full platelet inhibition with aspirin and thienopyridines before coronary stenting has significantly reduced the risk of acute stent thrombosis, peri-procedural myonecrosis still occurs frequently and is associated with increased death rate." | 5.11 | Does pre-treatment with aspirin and loading dose clopidogrel obviate the need for glycoprotein IIb/IIIa antagonists during elective coronary stenting? A focus on peri-procedural myonecrosis. ( Bosmans, JM; Claeys, MJ; Michiels, JJ; Van Der Goten, P; Van der Planken, MG; Vertessen, F; Vrints, CJ; Wuyts, FL, 2005) |
| "Color vision function was measured at baseline in 2,701 patients enrolled in the Early Treatment Diabetic Retinopathy Study, a randomized trial investigating photocoagulation and aspirin in the treatment of diabetic retinopathy." | 5.09 | Impaired color vision associated with diabetic retinopathy: Early Treatment Diabetic Retinopathy Study Report No. 15. ( Barton, FB; Bresnick, GH; Fong, DS, 1999) |
| " Aspirin (acetylsalicylic acid) has been shown to reduce atherosclerosis-related events as well as development of certain tumors." | 3.77 | Angiostatic effects of aspirin in hypoxia-reoxygenation are linked to modulation of TGFβ1 signaling. ( Khaidakov, M; Mehta, JL; Mitra, S; Szwedo, J, 2011) |
| " In a mouse model of hypoxia-induced retinal angiogenesis, the situation of thrombocytopenia as well as inhibition of platelet aggregation by a highly specific alphaIIbbeta3-integrin antagonist or acetyl salicylic acid (Aspirin) administration, respectively, resulted in about 35-50% reduction of retinal neovascularization, compatible with a significant contribution of blood platelets in angiogenesis." | 3.72 | The functional role of blood platelet components in angiogenesis. ( Black, M; Fischer, S; Hammes, HP; Morgenstern, E; Preissner, KT; Rhee, JS; Schubert, U, 2004) |
| "The growth rate (studied by mean tumor dry weight) and vascularization (studied by microangiography) of two transplantable rat tumors, a 20-methylcholanthrene-induced fibrosarcoma and a hepatoma, were significantly reduced by three prostaglandin synthesis inhibitors, indomethacin, diclofenac-sodium and aspirin, irrespective of whether the drugs were administered early or late during tumor growth." | 3.66 | Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat. ( Peterson, HI, 1983) |
| "Aspirin is an old drug extracted from willow bark and is widely used for the prevention and treatment of cardiovascular diseases." | 2.72 | Mechanisms of the antiangiogenic effects of aspirin in cancer. ( Huang, Y; Wang, Y; Xie, S; Yang, B, 2021) |
| "Aspirin use has been shown to be associated with reduced risk of aggressive prostate cancer, although the mechanisms are not fully understood." | 1.72 | Aspirin use and prostate tumor angiogenesis. ( Clinton, SK; Fu, BC; Giovannucci, EL; Mucci, LA; Wang, K, 2022) |
| "Rosacea is a chronic, relapsing inflammatory skin disease featured by abnormal activation of immune responses, vascular dysfunction and prominent permeability barrier alterations." | 1.62 | Aspirin alleviates skin inflammation and angiogenesis in rosacea. ( Chen, M; Deng, Z; Li, J; Liu, T; Peng, Q; Sha, K; Wang, B; Xiao, W; Xie, H; Xu, S; Zhang, Y, 2021) |
| "Platelets also promoted cancer cell invasion in vitro." | 1.56 | Platelets disrupt vasculogenic mimicry by cancer cells. ( Bonder, CS; Cockshell, MP; Dale, BJ; Ebert, LM; Hyslop, SR; Josefsson, EC; Martini, C; Thompson, EJ; Woods, AE, 2020) |
| "Of note, patients with breast cancer receiving aspirin had lower circulating IL-8, and their platelets did not increase tumor cell invasion compared with patients not receiving aspirin." | 1.51 | Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis. ( Battinelli, EM; Ceglowski, JR; Chen, WY; El-Husayni, S; Forward, JA; Italiano, JE; Johnson, KE; Kulenthirarajan, R; Machlus, KR; Malloy, MW; Roweth, HG; Tippy, MD, 2019) |
| "Aspirin-PC was more potent (vs." | 1.43 | Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer. ( Bottsford-Miller, JN; Dial, EJ; Dorniak, PL; Fang, D; Filant, J; Haemmerle, M; Hansen, JM; Hatakeyama, H; Hu, W; Huang, Y; Lichtenberger, LM; Lyons, Y; Pradeep, S; Previs, RA; Shen, F; Sood, AK; Taylor, M; Wagner, MJ, 2016) |
| "Stroke is the major cause of death and decrease in the activities of daily living." | 1.40 | Neurovascular protection of cilostazol in stroke-prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation. ( Abe, K; Deguchi, K; Ikeda, Y; Kono, S; Kurata, T; Liu, N; Liu, W; Omote, Y; Yamashita, T, 2014) |
| "Rheumatoid arthritis is a chronic inflammatory disease characterized by overproduction of inflammatory mediators along with undermined oxidative defensive mechanisms." | 1.40 | Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. ( El-Azab, MF; El-Sayed, RM; Moustafa, YM, 2014) |
| "Aspirin is a salicylate drug that is widely used, and recently it has been shown to influence the development of various types of cancers." | 1.39 | Impact of acetylsalicylic acid on tumor angiogenesis and lymphangiogenesis through inhibition of VEGF signaling in a murine sarcoma model. ( Jia, Q; Wang, Z; Wu, L; Zhang, W; Zhang, X; Zhang, Y, 2013) |
| "In support of this, the breast cancer cell line MCF-7 stimulated secretion of VEGF and a pro-angiogenic releasate from platelets." | 1.37 | Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis. ( Battinelli, EM; Italiano, JE; Markens, BA, 2011) |
| "Aspirin resistance was defined when epinephrine closure time <174 s." | 1.34 | Prevalence and biologic profile of aspirin resistance in patients with angiographically proven coronary artery disease. ( de Lafuente, JP; Iriarte, JA; Lafita, M; Molinero, E; Monica, S; Narvaez, I; Saez, Y; Sagastagoitia, JD; Vacas, M, 2007) |
| "Symptomatic pulmonary manifestations of Kawasaki disease (KD) are uncommon." | 1.32 | Inflammatory pulmonary nodules in Kawasaki disease. ( Cornwall, ML; Crawford, SE; Ferrando-Monleón, S; Finn, LS; Freeman, AF; López-Andreu, JA; Pérez-Tamarit, D; Rowley, AH; Shulman, ST, 2003) |
| "We found that colon cancer medium-induced COX-2 protein expression in EC and aspirin or sodium salicylate suppressed the cancer-induced COX-2 protein levels at concentrations correlated with those that suppressed endothelial tube formation." | 1.32 | Aspirin and salicylate inhibit colon cancer medium- and VEGF-induced endothelial tube formation: correlation with suppression of cyclooxygenase-2 expression. ( Juneja, HS; Lee, S; Shtivelband, MI; Wu, KK, 2003) |
| "Ticlopidine treatment resulted in increased platelet endostatin content and release." | 1.31 | Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. ( Buret, A; Cirino, G; Elliott, SN; Ignarro, LJ; Ma, L; Wallace, JL, 2001) |
| "We report a case of unilateral central retinal vein occlusion resulting from essential thrombocythemia, a rare myeloproliferative disorder with abnormally increased platelet count." | 1.29 | Essential thrombocythemia and central retinal vein occlusion with neovascular glaucoma. ( Townsend-Pico, W; Yoshizumi, MO, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (8.47) | 18.7374 |
| 1990's | 5 (8.47) | 18.2507 |
| 2000's | 22 (37.29) | 29.6817 |
| 2010's | 21 (35.59) | 24.3611 |
| 2020's | 6 (10.17) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, BC | 1 |
| Wang, K | 1 |
| Mucci, LA | 1 |
| Clinton, SK | 1 |
| Giovannucci, EL | 1 |
| Mueller-Diesing, F | 1 |
| Lederle, W | 1 |
| Rix, A | 1 |
| Koletnik, S | 1 |
| Doleschel, D | 1 |
| Snelting, M | 1 |
| Gremse, F | 1 |
| Kiessling, F | 1 |
| Martini, C | 1 |
| Thompson, EJ | 1 |
| Hyslop, SR | 1 |
| Cockshell, MP | 1 |
| Dale, BJ | 1 |
| Ebert, LM | 1 |
| Woods, AE | 1 |
| Josefsson, EC | 1 |
| Bonder, CS | 1 |
| Zhang, Z | 1 |
| Li, S | 1 |
| Deng, J | 1 |
| Yang, S | 1 |
| Xiang, Z | 1 |
| Guo, H | 1 |
| Xi, H | 1 |
| Sang, M | 1 |
| Zhang, W | 2 |
| Xie, S | 1 |
| Wang, Y | 1 |
| Huang, Y | 2 |
| Yang, B | 1 |
| Deng, Z | 1 |
| Xu, S | 1 |
| Peng, Q | 1 |
| Sha, K | 1 |
| Xiao, W | 1 |
| Liu, T | 1 |
| Zhang, Y | 2 |
| Wang, B | 1 |
| Xie, H | 1 |
| Chen, M | 1 |
| Li, J | 1 |
| Dai, X | 1 |
| Yan, J | 1 |
| Fu, X | 1 |
| Pan, Q | 1 |
| Sun, D | 1 |
| Xu, Y | 1 |
| Wang, J | 1 |
| Nie, L | 1 |
| Tong, L | 1 |
| Shen, A | 1 |
| Zheng, M | 1 |
| Huang, M | 1 |
| Tan, M | 1 |
| Liu, H | 1 |
| Huang, X | 1 |
| Ding, J | 1 |
| Geng, M | 1 |
| Verma, S | 1 |
| Das, P | 1 |
| Kumar, VL | 1 |
| Chighizola, CB | 1 |
| Shoenfeld, Y | 1 |
| Meroni, PL | 1 |
| Hsieh, CC | 1 |
| Wang, CH | 1 |
| Johnson, KE | 1 |
| Ceglowski, JR | 1 |
| Roweth, HG | 1 |
| Forward, JA | 1 |
| Tippy, MD | 1 |
| El-Husayni, S | 1 |
| Kulenthirarajan, R | 1 |
| Malloy, MW | 1 |
| Machlus, KR | 1 |
| Chen, WY | 1 |
| Italiano, JE | 2 |
| Battinelli, EM | 2 |
| Zhang, X | 1 |
| Wang, Z | 2 |
| Jia, Q | 1 |
| Wu, L | 1 |
| Etulain, J | 1 |
| Fondevila, C | 1 |
| Negrotto, S | 1 |
| Schattner, M | 1 |
| Salvado, MD | 1 |
| Di Gennaro, A | 1 |
| Lindbom, L | 1 |
| Agerberth, B | 1 |
| Haeggström, JZ | 1 |
| Palladino, M | 1 |
| Gatto, I | 1 |
| Neri, V | 1 |
| Straino, S | 1 |
| Smith, RC | 1 |
| Silver, M | 1 |
| Gaetani, E | 1 |
| Marcantoni, M | 1 |
| Giarretta, I | 1 |
| Stigliano, E | 1 |
| Capogrossi, M | 1 |
| Hlatky, L | 1 |
| Landolfi, R | 1 |
| Pola, R | 1 |
| Omote, Y | 1 |
| Deguchi, K | 1 |
| Kono, S | 1 |
| Liu, N | 1 |
| Liu, W | 1 |
| Kurata, T | 1 |
| Yamashita, T | 1 |
| Ikeda, Y | 1 |
| Abe, K | 1 |
| El-Sayed, RM | 1 |
| Moustafa, YM | 1 |
| El-Azab, MF | 1 |
| Usman, MW | 1 |
| Luo, F | 1 |
| Cheng, H | 1 |
| Zhao, JJ | 1 |
| Liu, P | 1 |
| Franco, AT | 1 |
| Corken, A | 1 |
| Ware, J | 1 |
| Rauzi, F | 1 |
| Kirkby, NS | 1 |
| Edin, ML | 1 |
| Whiteford, J | 1 |
| Zeldin, DC | 1 |
| Mitchell, JA | 1 |
| Warner, TD | 1 |
| Lichtenberger, LM | 1 |
| Taylor, M | 1 |
| Bottsford-Miller, JN | 1 |
| Haemmerle, M | 1 |
| Wagner, MJ | 1 |
| Lyons, Y | 1 |
| Pradeep, S | 1 |
| Hu, W | 1 |
| Previs, RA | 1 |
| Hansen, JM | 1 |
| Fang, D | 1 |
| Dorniak, PL | 1 |
| Filant, J | 1 |
| Dial, EJ | 1 |
| Shen, F | 1 |
| Hatakeyama, H | 1 |
| Sood, AK | 1 |
| Ouyang, N | 1 |
| Williams, JL | 1 |
| Rigas, B | 2 |
| Farahvash, MS | 1 |
| Farahvash, MM | 1 |
| Moradimogadam, M | 1 |
| Mohammadzadeh, S | 1 |
| Hyde, CA | 1 |
| Missailidis, S | 1 |
| Green, DL | 1 |
| Karpatkin, S | 1 |
| Khaidakov, M | 1 |
| Szwedo, J | 1 |
| Mitra, S | 1 |
| Mehta, JL | 1 |
| Goertz, O | 1 |
| Ring, A | 1 |
| Buschhaus, B | 1 |
| Hirsch, T | 1 |
| Daigeler, A | 1 |
| Steinstraesser, L | 1 |
| Steinau, HU | 1 |
| Langer, S | 1 |
| Gravitz, L | 1 |
| Markens, BA | 1 |
| Belotti, A | 1 |
| Elli, E | 1 |
| Speranza, T | 1 |
| Lanzi, E | 1 |
| Pioltelli, P | 1 |
| Pogliani, E | 1 |
| Ma, C | 1 |
| Wang, Q | 1 |
| Man, Y | 1 |
| Kemmner, W | 1 |
| Brown, JR | 2 |
| Seed, MP | 2 |
| Willoughby, DA | 2 |
| Freeman, AF | 1 |
| Crawford, SE | 1 |
| Finn, LS | 1 |
| López-Andreu, JA | 1 |
| Ferrando-Monleón, S | 1 |
| Pérez-Tamarit, D | 1 |
| Cornwall, ML | 1 |
| Shulman, ST | 1 |
| Rowley, AH | 1 |
| Shtivelband, MI | 1 |
| Juneja, HS | 1 |
| Lee, S | 1 |
| Wu, KK | 1 |
| Garcia-Porrua, C | 1 |
| Pego-Reigosa, R | 1 |
| Armesto, V | 1 |
| Gonzalez-Gay, MA | 1 |
| Yoshida, S | 1 |
| Amano, H | 1 |
| Hayashi, I | 1 |
| Kitasato, H | 1 |
| Kamata, M | 1 |
| Inukai, M | 1 |
| Yoshimura, H | 1 |
| Majima, M | 1 |
| Pourati, I | 1 |
| Kimmelstiel, C | 1 |
| Rand, W | 1 |
| Karas, RH | 1 |
| Rhee, JS | 1 |
| Black, M | 1 |
| Schubert, U | 1 |
| Fischer, S | 1 |
| Morgenstern, E | 1 |
| Hammes, HP | 1 |
| Preissner, KT | 1 |
| Claeys, MJ | 1 |
| Van der Planken, MG | 1 |
| Bosmans, JM | 1 |
| Michiels, JJ | 1 |
| Vertessen, F | 1 |
| Van Der Goten, P | 1 |
| Wuyts, FL | 1 |
| Vrints, CJ | 1 |
| Ghezzo, F | 1 |
| Cesano, L | 1 |
| Mognetti, B | 1 |
| Pesce, E | 1 |
| Pirro, E | 1 |
| Corvetti, G | 1 |
| Berta, GN | 1 |
| Zingaro, B | 1 |
| Di Carlo, F | 1 |
| Thiex, R | 1 |
| Küker, W | 1 |
| Jungbluth, P | 1 |
| Kayser, C | 1 |
| Müller, HD | 1 |
| Rohde, I | 1 |
| Gilsbach, JM | 1 |
| Rohde, V | 1 |
| Cezar-de-Mello, PF | 1 |
| Nascimento-Silva, V | 1 |
| Villela, CG | 1 |
| Fierro, IM | 1 |
| Narvaez, I | 1 |
| Sagastagoitia, JD | 1 |
| Vacas, M | 1 |
| Saez, Y | 1 |
| Lafita, M | 1 |
| Monica, S | 1 |
| de Lafuente, JP | 1 |
| Molinero, E | 1 |
| Iriarte, JA | 1 |
| Holmes, CE | 1 |
| Huang, JC | 1 |
| Pace, TR | 1 |
| Howard, AB | 1 |
| Muss, HB | 1 |
| McAuslan, BR | 1 |
| Gole, GA | 1 |
| Kamiński, MJ | 1 |
| Majewski, S | 1 |
| Kamińska, G | 1 |
| Bem, W | 1 |
| Szmurło, A | 1 |
| Peterson, HI | 1 |
| Valone, J | 1 |
| Yoshizumi, MO | 1 |
| Townsend-Pico, W | 1 |
| Freemantle, CN | 1 |
| Alam, CA | 1 |
| Colville-Nash, PR | 1 |
| Papworth, JL | 1 |
| Somerville, KW | 1 |
| Horan, AH | 1 |
| Fong, DS | 1 |
| Barton, FB | 1 |
| Bresnick, GH | 1 |
| Shiff, SJ | 1 |
| Yogo, K | 1 |
| Shimokawa, H | 1 |
| Funakoshi, H | 1 |
| Kandabashi, T | 1 |
| Miyata, K | 1 |
| Okamoto, S | 1 |
| Egashira, K | 1 |
| Huang, P | 1 |
| Akaike, T | 1 |
| Takeshita, A | 1 |
| Samaniego, F | 1 |
| Pati, S | 1 |
| Karp, JE | 1 |
| Prakash, O | 1 |
| Bose, D | 1 |
| Ma, L | 1 |
| Elliott, SN | 1 |
| Cirino, G | 1 |
| Buret, A | 1 |
| Ignarro, LJ | 1 |
| Wallace, JL | 1 |
| Bing, RJ | 1 |
| Narumiya, S | 1 |
| FitzGerald, GA | 1 |
| Patz, A | 1 |
| Finkelstein, D | 1 |
| Fine, SL | 1 |
| Murphy, RP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mobilization of Endothelial Progenitor Cells Following Alcohol Septal Ablation in Hypertrophic Obstructive Cardiomyopathy: Randomized Controlled Trial of Aspirin[NCT02674958] | Phase 3 | 6 participants (Actual) | Interventional | 2016-05-31 | Terminated (stopped due to Covid-19 pandemic) | ||
| Gastrointestinal Ulceration in Patients on Dual Antiplatelet Therapy After Percutaneous Coronary Intervention[NCT00413309] | 30 participants (Anticipated) | Interventional | 2006-04-30 | Completed | |||
| Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer[NCT02418312] | 228 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Pantoprazole Versus Famotidine for the Prevention of Recurrent Peptic Ulcers in Thienopyridine Users - a Double-blind Randomized Controlled Trial[NCT02551744] | 101 participants (Actual) | Interventional | 2012-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Follow-up endoscopy was performed at the end of the 6th month (NCT02418312)
Timeframe: 6 months
| Intervention | participants (Number) |
|---|---|
| Histamine-2 Receptor Antagonist Group | 106 |
| Placebo Group | 101 |
Follow-up endoscopy was performed at the end of the 6th month (NCT02551744)
Timeframe: six month
| Intervention | participants (Number) |
|---|---|
| Proton Pump Inhibitor Group | 1 |
| Histamine-2 Receptor Antagonist Group | 7 |
9 reviews available for aspirin and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Mechanisms of the antiangiogenic effects of aspirin in cancer.
Topics: Angiogenesis Inhibitors; Animals; Aspirin; Humans; Neoplasms; Neovascularization, Pathologic; Signal | 2021 |
Chemopreventive effects of aspirin at a glance.
Topics: Anticarcinogenic Agents; Aspirin; Cyclooxygenase 1; Cyclooxygenase Inhibitors; DNA Damage; Humans; N | 2015 |
Platelets at the interface of thrombosis, inflammation, and cancer.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Blood Platelets; Cell Death; Cell Proliferation; Cell-Der | 2015 |
Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis.
Topics: Animals; Antineoplastic Agents; Arachidonic Acid; Aspirin; Cell Cycle Proteins; Cell Proliferation; | 2009 |
Effect of cancer on platelets.
Topics: Animals; Aspirin; Blood Platelets; Cell Adhesion; Clinical Trials as Topic; Endothelium, Vascular; H | 2009 |
Cardiovascular medications in angiogenesis--how to avoid the sting in the tail.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Aspirin; Calcium Cha | 2012 |
Proliferative diabetic retinopathy and patient age: presentation, prognosis, and management.
Topics: Adolescent; Adult; Age Factors; Anticoagulants; Aspirin; Diabetes Mellitus, Type 1; Diabetic Retinop | 1984 |
Myocardial ischemia and infarction: growth of ideas.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; Cyclooxygenase Inhibit | 2001 |
Genetic and pharmacological analysis of prostanoid receptor function.
Topics: Animals; Aspirin; Biological Transport; Bone Resorption; Cell Nucleus; Colonic Neoplasms; Cyclooxyge | 2001 |
4 trials available for aspirin and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion.
Topics: Aspirin; Dalteparin; Female; Fibrinolytic Agents; Humans; Iris; Male; Middle Aged; Neovascularizatio | 2008 |
Does pre-treatment with aspirin and loading dose clopidogrel obviate the need for glycoprotein IIb/IIIa antagonists during elective coronary stenting? A focus on peri-procedural myonecrosis.
Topics: Abciximab; Aged; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Angiography; Coronary Diseas | 2005 |
Tamoxifen and aromatase inhibitors differentially affect vascular endothelial growth factor and endostatin levels in women with breast cancer.
Topics: Adult; Antineoplastic Agents; Aromatase Inhibitors; Aspirin; Blood Platelets; Breast Neoplasms; Endo | 2008 |
Impaired color vision associated with diabetic retinopathy: Early Treatment Diabetic Retinopathy Study Report No. 15.
Topics: Adolescent; Adult; Aged; Aging; Aspirin; Color; Color Perception; Diabetic Retinopathy; Discriminati | 1999 |
46 other studies available for aspirin and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Aspirin use and prostate tumor angiogenesis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Follow-Up Studies; Humans; Male; Neovascularizatio | 2022 |
Molecular Ultrasound Imaging Depicts the Modulation of Tumor Angiogenesis by Acetylsalicylic Acid.
Topics: Animals; Aspirin; Mice; Neoplasms; Neovascularization, Pathologic; Ultrasonography; Vascular Endothe | 2023 |
Platelets disrupt vasculogenic mimicry by cancer cells.
Topics: Animals; Apoptosis; Aspirin; Blood Platelets; Breast Neoplasms; Cell Line, Tumor; Female; Male; Mela | 2020 |
Aspirin inhibits endometrial fibrosis by suppressing the TGF‑β1‑Smad2/Smad3 pathway in intrauterine adhesions.
Topics: Adult; Aspirin; Endometrium; Estrogens; Female; Fibrosis; Humans; Neovascularization, Pathologic; Re | 2020 |
Aspirin alleviates skin inflammation and angiogenesis in rosacea.
Topics: Animals; Anti-Inflammatory Agents; Antimicrobial Cationic Peptides; Aspirin; Cathelicidins; Dermatit | 2021 |
Aspirin Inhibits Cancer Metastasis and Angiogenesis via Targeting Heparanase.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Aspirin; Cell Line, Tumor; Chick Embryo; Di | 2017 |
Chemoprevention by artesunate in a preclinical model of colorectal cancer involves down regulation of β-catenin, suppression of angiogenesis, cellular proliferation and induction of apoptosis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Apoptosis; Artemisinins; Artesunate; Aspirin; b | 2017 |
Therapy for antiphospholipid miscarriages: Throwing the baby out with the bathwater?
Topics: Abortion, Habitual; Antibodies, Antiphospholipid; Aspirin; Drug Therapy, Combination; Endometrium; E | 2018 |
Aspirin Disrupts the Crosstalk of Angiogenic and Inflammatory Cytokines between 4T1 Breast Cancer Cells and Macrophages.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Cell Line, Tumor | 2018 |
Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis.
Topics: Aspirin; Blood Platelets; Breast Neoplasms; Cell Line, Tumor; Cytokines; Female; Humans; Neoplasm Me | 2019 |
Impact of acetylsalicylic acid on tumor angiogenesis and lymphangiogenesis through inhibition of VEGF signaling in a murine sarcoma model.
Topics: Animals; Aspirin; Fluorouracil; Lymphangiogenesis; Lymphatic Vessels; Male; Mice; Neovascularization | 2013 |
Platelet-mediated angiogenesis is independent of VEGF and fully inhibited by aspirin.
Topics: Aspirin; Blood Platelets; Cell Proliferation; Endostatins; Endothelial Cells; Humans; In Vitro Techn | 2013 |
Cathelicidin LL-37 induces angiogenesis via PGE2-EP3 signaling in endothelial cells, in vivo inhibition by aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimicrobial Cationic Peptides; Aspirin; Calcium; Cathelic | 2013 |
Angiogenic impairment of the vascular endothelium: a novel mechanism and potential therapeutic target in muscular dystrophy.
Topics: Animals; Apoptosis; Aspirin; Carcinoma, Lewis Lung; Caveolin 1; Cell Movement; Cell Proliferation; C | 2013 |
Neurovascular protection of cilostazol in stroke-prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation.
Topics: Animals; Antigens; Aspirin; Cerebrovascular Circulation; Cilostazol; Clopidogrel; Disease Models, An | 2014 |
Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1.
Topics: Administration, Oral; Angiopoietin-1; Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Ex | 2014 |
Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.
Topics: Aspirin; Blood Platelets; Cells, Cultured; Cyclooxygenase 1; Eicosanoids; Endothelium; Humans; Hydro | 2016 |
Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Biomarkers; Cell Line, | 2016 |
NO-donating aspirin inhibits angiogenesis by suppressing VEGF expression in HT-29 human colon cancer mouse xenografts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; HT29 Cells; Humans; Im | 2008 |
Angiostatic effects of aspirin in hypoxia-reoxygenation are linked to modulation of TGFβ1 signaling.
Topics: Angiogenesis Inhibitors; Aspirin; Atherosclerosis; Cell Hypoxia; Cell Migration Assays; Cells, Cultu | 2011 |
Influence of anti-inflammatory and vasoactive drugs on microcirculation and angiogenesis after burn in mice.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Burns; Disease Models, Animal; Endothelium; Injections, | 2011 |
Chemoprevention: First line of defence.
Topics: Animals; Aspirin; Celecoxib; Clinical Trials, Phase II as Topic; Colonic Neoplasms; Cyclooxygenase I | 2011 |
Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis.
Topics: Adenosine Diphosphate; Angiogenesis Modulating Agents; Aspirin; Blood Platelets; Breast Neoplasms; C | 2011 |
Circulating endothelial cells and endothelial activation in essential thrombocythemia: results from CD146+ immunomagnetic enrichment--flow cytometry and soluble E-selectin detection.
Topics: Alkylating Agents; Anticoagulants; Aspirin; CD146 Antigen; Drug Therapy, Combination; E-Selectin; En | 2012 |
Relationship between apoptosis, angiogenesis and colon-26 tumour growth after oral NSAID-treatment.
Topics: Adenocarcinoma; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; A | 2002 |
Inflammatory pulmonary nodules in Kawasaki disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Immunoglobulin A; Immunoglobulins, Intrave | 2003 |
Aspirin and salicylate inhibit colon cancer medium- and VEGF-induced endothelial tube formation: correlation with suppression of cyclooxygenase-2 expression.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cells, Cultured; Collagen; Colo | 2003 |
Neovascularization around the optic nerve in giant cell arteritis.
Topics: Aged; Aspirin; Giant Cell Arteritis; Humans; Magnetic Resonance Imaging; Male; Neovascularization, P | 2003 |
COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo.
Topics: Animals; Antibodies, Blocking; Aspirin; Benzenesulfonates; Carcinoma, Lewis Lung; Cyclooxygenase Inh | 2003 |
Statin use is associated with enhanced collateralization of severely diseased coronary arteries.
Topics: Aged; Aspirin; Atorvastatin; Calcium Channels; Collateral Circulation; Coronary Angiography; Coronar | 2003 |
The functional role of blood platelet components in angiogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Component Transfusion; Blood Platel | 2004 |
Salicylate inhibition of rat mammary carcinogenesis and angiogenesis in female rat compatible with misoprostol administration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Transformation, Neoplastic; Disease | 2005 |
Minor inflammation after surgical evacuation compared with fibrinolytic therapy of experimental intracerebral hemorrhages.
Topics: Analysis of Variance; Animals; Aspirin; Blood Transfusion, Autologous; Cerebral Hemorrhage; Confiden | 2005 |
Aspirin-triggered Lipoxin A4 inhibition of VEGF-induced endothelial cell migration involves actin polymerization and focal adhesion assembly.
Topics: Actins; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Adhesion; Cell Movement; Cells, Cultu | 2006 |
Prevalence and biologic profile of aspirin resistance in patients with angiographically proven coronary artery disease.
Topics: Aged; Apolipoproteins B; Aspirin; Blood Platelets; Coronary Artery Disease; Drug Resistance; Epineph | 2007 |
Cellular and molecular mechanisms in angiogenesis.
Topics: Animals; Anterior Chamber; Aspirin; Carcinoma 256, Walker; Cell Movement; Copper; Copper Sulfate; Co | 1980 |
Protease-mediated enhancement of lymphocyte-induced angiogenesis in X-ray irradiated mice.
Topics: Aminocaproic Acid; Animals; Aprotinin; Aspirin; Cortisone; Dose-Response Relationship, Radiation; Fe | 1983 |
Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat.
Topics: Animals; Aspirin; Diclofenac; Fibrosarcoma; Indomethacin; Liver Neoplasms, Experimental; Neoplasm Tr | 1983 |
Essential thrombocythemia and central retinal vein occlusion with neovascular glaucoma.
Topics: Adrenergic beta-Antagonists; Antisickling Agents; Aspirin; Bone Marrow; Fluorescein Angiography; Fun | 1996 |
Apoptosis induction and inhibition of colon-26 tumour growth and angiogenesis: findings on COX-1 and COX-2 inhibitors in vitro & in vivo and topical diclofenac in hyaluronan.
Topics: Administration, Topical; Animals; Apoptosis; Aspirin; Cell Division; Cell Survival; Colonic Neoplasm | 1997 |
Re: Advances in angiogenesis research: relevance to urological oncology.
Topics: Aspirin; Humans; Male; Neovascularization, Pathologic; Prostatic Neoplasms; Research | 1998 |
Aspirin for cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Humans; Neopla | 1999 |
Different vasculoprotective roles of NO synthase isoforms in vascular lesion formation in mice.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Aspirin; Carotid Arteries; Female; F | 2000 |
Human herpesvirus 8 K1-associated nuclear factor-kappa B-dependent promoter activity: role in Kaposi's sarcoma inflammation?
Topics: Amino Acid Motifs; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chlorocebus aethiops; | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
The role of fluorescein angiography in national collaborative studies.
Topics: Aspirin; Choroid; Clinical Trials as Topic; Diabetic Retinopathy; Fluorescein Angiography; Forecasti | 1986 |