Page last updated: 2024-10-23

aspirin and Angiogenesis, Pathologic

aspirin has been researched along with Angiogenesis, Pathologic in 59 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"To compare the long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion with that of aspirin."9.13Long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion. ( Farahvash, MM; Farahvash, MS; Mohammadzadeh, S; Moradimogadam, M, 2008)
"VEGF and endostatin concentrations were measured with a quantitative immunoassay before and after 1 to 5 weeks of treatment in 30 women with breast cancer treated with either tamoxifen (n = 14) or aromatase inhibitors (n = 16)."9.13Tamoxifen and aromatase inhibitors differentially affect vascular endothelial growth factor and endostatin levels in women with breast cancer. ( Holmes, CE; Howard, AB; Huang, JC; Muss, HB; Pace, TR, 2008)
"Rosacea is a chronic, relapsing inflammatory skin disease featured by abnormal activation of immune responses, vascular dysfunction and prominent permeability barrier alterations."5.62Aspirin alleviates skin inflammation and angiogenesis in rosacea. ( Chen, M; Deng, Z; Li, J; Liu, T; Peng, Q; Sha, K; Wang, B; Xiao, W; Xie, H; Xu, S; Zhang, Y, 2021)
"Stroke is the major cause of death and decrease in the activities of daily living."5.40Neurovascular protection of cilostazol in stroke-prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation. ( Abe, K; Deguchi, K; Ikeda, Y; Kono, S; Kurata, T; Liu, N; Liu, W; Omote, Y; Yamashita, T, 2014)
"Rheumatoid arthritis is a chronic inflammatory disease characterized by overproduction of inflammatory mediators along with undermined oxidative defensive mechanisms."5.40Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. ( El-Azab, MF; El-Sayed, RM; Moustafa, YM, 2014)
"Aspirin resistance was defined when epinephrine closure time <174 s."5.34Prevalence and biologic profile of aspirin resistance in patients with angiographically proven coronary artery disease. ( de Lafuente, JP; Iriarte, JA; Lafita, M; Molinero, E; Monica, S; Narvaez, I; Saez, Y; Sagastagoitia, JD; Vacas, M, 2007)
"To compare the long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion with that of aspirin."5.13Long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion. ( Farahvash, MM; Farahvash, MS; Mohammadzadeh, S; Moradimogadam, M, 2008)
"VEGF and endostatin concentrations were measured with a quantitative immunoassay before and after 1 to 5 weeks of treatment in 30 women with breast cancer treated with either tamoxifen (n = 14) or aromatase inhibitors (n = 16)."5.13Tamoxifen and aromatase inhibitors differentially affect vascular endothelial growth factor and endostatin levels in women with breast cancer. ( Holmes, CE; Howard, AB; Huang, JC; Muss, HB; Pace, TR, 2008)
"Although full platelet inhibition with aspirin and thienopyridines before coronary stenting has significantly reduced the risk of acute stent thrombosis, peri-procedural myonecrosis still occurs frequently and is associated with increased death rate."5.11Does pre-treatment with aspirin and loading dose clopidogrel obviate the need for glycoprotein IIb/IIIa antagonists during elective coronary stenting? A focus on peri-procedural myonecrosis. ( Bosmans, JM; Claeys, MJ; Michiels, JJ; Van Der Goten, P; Van der Planken, MG; Vertessen, F; Vrints, CJ; Wuyts, FL, 2005)
"Color vision function was measured at baseline in 2,701 patients enrolled in the Early Treatment Diabetic Retinopathy Study, a randomized trial investigating photocoagulation and aspirin in the treatment of diabetic retinopathy."5.09Impaired color vision associated with diabetic retinopathy: Early Treatment Diabetic Retinopathy Study Report No. 15. ( Barton, FB; Bresnick, GH; Fong, DS, 1999)
" Aspirin (acetylsalicylic acid) has been shown to reduce atherosclerosis-related events as well as development of certain tumors."3.77Angiostatic effects of aspirin in hypoxia-reoxygenation are linked to modulation of TGFβ1 signaling. ( Khaidakov, M; Mehta, JL; Mitra, S; Szwedo, J, 2011)
" In a mouse model of hypoxia-induced retinal angiogenesis, the situation of thrombocytopenia as well as inhibition of platelet aggregation by a highly specific alphaIIbbeta3-integrin antagonist or acetyl salicylic acid (Aspirin) administration, respectively, resulted in about 35-50% reduction of retinal neovascularization, compatible with a significant contribution of blood platelets in angiogenesis."3.72The functional role of blood platelet components in angiogenesis. ( Black, M; Fischer, S; Hammes, HP; Morgenstern, E; Preissner, KT; Rhee, JS; Schubert, U, 2004)
"The growth rate (studied by mean tumor dry weight) and vascularization (studied by microangiography) of two transplantable rat tumors, a 20-methylcholanthrene-induced fibrosarcoma and a hepatoma, were significantly reduced by three prostaglandin synthesis inhibitors, indomethacin, diclofenac-sodium and aspirin, irrespective of whether the drugs were administered early or late during tumor growth."3.66Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat. ( Peterson, HI, 1983)
"Aspirin is an old drug extracted from willow bark and is widely used for the prevention and treatment of cardiovascular diseases."2.72Mechanisms of the antiangiogenic effects of aspirin in cancer. ( Huang, Y; Wang, Y; Xie, S; Yang, B, 2021)
"Aspirin use has been shown to be associated with reduced risk of aggressive prostate cancer, although the mechanisms are not fully understood."1.72Aspirin use and prostate tumor angiogenesis. ( Clinton, SK; Fu, BC; Giovannucci, EL; Mucci, LA; Wang, K, 2022)
"Rosacea is a chronic, relapsing inflammatory skin disease featured by abnormal activation of immune responses, vascular dysfunction and prominent permeability barrier alterations."1.62Aspirin alleviates skin inflammation and angiogenesis in rosacea. ( Chen, M; Deng, Z; Li, J; Liu, T; Peng, Q; Sha, K; Wang, B; Xiao, W; Xie, H; Xu, S; Zhang, Y, 2021)
"Platelets also promoted cancer cell invasion in vitro."1.56Platelets disrupt vasculogenic mimicry by cancer cells. ( Bonder, CS; Cockshell, MP; Dale, BJ; Ebert, LM; Hyslop, SR; Josefsson, EC; Martini, C; Thompson, EJ; Woods, AE, 2020)
"Of note, patients with breast cancer receiving aspirin had lower circulating IL-8, and their platelets did not increase tumor cell invasion compared with patients not receiving aspirin."1.51Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis. ( Battinelli, EM; Ceglowski, JR; Chen, WY; El-Husayni, S; Forward, JA; Italiano, JE; Johnson, KE; Kulenthirarajan, R; Machlus, KR; Malloy, MW; Roweth, HG; Tippy, MD, 2019)
"Aspirin-PC was more potent (vs."1.43Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer. ( Bottsford-Miller, JN; Dial, EJ; Dorniak, PL; Fang, D; Filant, J; Haemmerle, M; Hansen, JM; Hatakeyama, H; Hu, W; Huang, Y; Lichtenberger, LM; Lyons, Y; Pradeep, S; Previs, RA; Shen, F; Sood, AK; Taylor, M; Wagner, MJ, 2016)
"Stroke is the major cause of death and decrease in the activities of daily living."1.40Neurovascular protection of cilostazol in stroke-prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation. ( Abe, K; Deguchi, K; Ikeda, Y; Kono, S; Kurata, T; Liu, N; Liu, W; Omote, Y; Yamashita, T, 2014)
"Rheumatoid arthritis is a chronic inflammatory disease characterized by overproduction of inflammatory mediators along with undermined oxidative defensive mechanisms."1.40Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. ( El-Azab, MF; El-Sayed, RM; Moustafa, YM, 2014)
"Aspirin is a salicylate drug that is widely used, and recently it has been shown to influence the development of various types of cancers."1.39Impact of acetylsalicylic acid on tumor angiogenesis and lymphangiogenesis through inhibition of VEGF signaling in a murine sarcoma model. ( Jia, Q; Wang, Z; Wu, L; Zhang, W; Zhang, X; Zhang, Y, 2013)
"In support of this, the breast cancer cell line MCF-7 stimulated secretion of VEGF and a pro-angiogenic releasate from platelets."1.37Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis. ( Battinelli, EM; Italiano, JE; Markens, BA, 2011)
"Aspirin resistance was defined when epinephrine closure time <174 s."1.34Prevalence and biologic profile of aspirin resistance in patients with angiographically proven coronary artery disease. ( de Lafuente, JP; Iriarte, JA; Lafita, M; Molinero, E; Monica, S; Narvaez, I; Saez, Y; Sagastagoitia, JD; Vacas, M, 2007)
"Symptomatic pulmonary manifestations of Kawasaki disease (KD) are uncommon."1.32Inflammatory pulmonary nodules in Kawasaki disease. ( Cornwall, ML; Crawford, SE; Ferrando-Monleón, S; Finn, LS; Freeman, AF; López-Andreu, JA; Pérez-Tamarit, D; Rowley, AH; Shulman, ST, 2003)
"We found that colon cancer medium-induced COX-2 protein expression in EC and aspirin or sodium salicylate suppressed the cancer-induced COX-2 protein levels at concentrations correlated with those that suppressed endothelial tube formation."1.32Aspirin and salicylate inhibit colon cancer medium- and VEGF-induced endothelial tube formation: correlation with suppression of cyclooxygenase-2 expression. ( Juneja, HS; Lee, S; Shtivelband, MI; Wu, KK, 2003)
"Ticlopidine treatment resulted in increased platelet endostatin content and release."1.31Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. ( Buret, A; Cirino, G; Elliott, SN; Ignarro, LJ; Ma, L; Wallace, JL, 2001)
"We report a case of unilateral central retinal vein occlusion resulting from essential thrombocythemia, a rare myeloproliferative disorder with abnormally increased platelet count."1.29Essential thrombocythemia and central retinal vein occlusion with neovascular glaucoma. ( Townsend-Pico, W; Yoshizumi, MO, 1996)

Research

Studies (59)

TimeframeStudies, this research(%)All Research%
pre-19905 (8.47)18.7374
1990's5 (8.47)18.2507
2000's22 (37.29)29.6817
2010's21 (35.59)24.3611
2020's6 (10.17)2.80

Authors

AuthorsStudies
Fu, BC1
Wang, K1
Mucci, LA1
Clinton, SK1
Giovannucci, EL1
Mueller-Diesing, F1
Lederle, W1
Rix, A1
Koletnik, S1
Doleschel, D1
Snelting, M1
Gremse, F1
Kiessling, F1
Martini, C1
Thompson, EJ1
Hyslop, SR1
Cockshell, MP1
Dale, BJ1
Ebert, LM1
Woods, AE1
Josefsson, EC1
Bonder, CS1
Zhang, Z1
Li, S1
Deng, J1
Yang, S1
Xiang, Z1
Guo, H1
Xi, H1
Sang, M1
Zhang, W2
Xie, S1
Wang, Y1
Huang, Y2
Yang, B1
Deng, Z1
Xu, S1
Peng, Q1
Sha, K1
Xiao, W1
Liu, T1
Zhang, Y2
Wang, B1
Xie, H1
Chen, M1
Li, J1
Dai, X1
Yan, J1
Fu, X1
Pan, Q1
Sun, D1
Xu, Y1
Wang, J1
Nie, L1
Tong, L1
Shen, A1
Zheng, M1
Huang, M1
Tan, M1
Liu, H1
Huang, X1
Ding, J1
Geng, M1
Verma, S1
Das, P1
Kumar, VL1
Chighizola, CB1
Shoenfeld, Y1
Meroni, PL1
Hsieh, CC1
Wang, CH1
Johnson, KE1
Ceglowski, JR1
Roweth, HG1
Forward, JA1
Tippy, MD1
El-Husayni, S1
Kulenthirarajan, R1
Malloy, MW1
Machlus, KR1
Chen, WY1
Italiano, JE2
Battinelli, EM2
Zhang, X1
Wang, Z2
Jia, Q1
Wu, L1
Etulain, J1
Fondevila, C1
Negrotto, S1
Schattner, M1
Salvado, MD1
Di Gennaro, A1
Lindbom, L1
Agerberth, B1
Haeggström, JZ1
Palladino, M1
Gatto, I1
Neri, V1
Straino, S1
Smith, RC1
Silver, M1
Gaetani, E1
Marcantoni, M1
Giarretta, I1
Stigliano, E1
Capogrossi, M1
Hlatky, L1
Landolfi, R1
Pola, R1
Omote, Y1
Deguchi, K1
Kono, S1
Liu, N1
Liu, W1
Kurata, T1
Yamashita, T1
Ikeda, Y1
Abe, K1
El-Sayed, RM1
Moustafa, YM1
El-Azab, MF1
Usman, MW1
Luo, F1
Cheng, H1
Zhao, JJ1
Liu, P1
Franco, AT1
Corken, A1
Ware, J1
Rauzi, F1
Kirkby, NS1
Edin, ML1
Whiteford, J1
Zeldin, DC1
Mitchell, JA1
Warner, TD1
Lichtenberger, LM1
Taylor, M1
Bottsford-Miller, JN1
Haemmerle, M1
Wagner, MJ1
Lyons, Y1
Pradeep, S1
Hu, W1
Previs, RA1
Hansen, JM1
Fang, D1
Dorniak, PL1
Filant, J1
Dial, EJ1
Shen, F1
Hatakeyama, H1
Sood, AK1
Ouyang, N1
Williams, JL1
Rigas, B2
Farahvash, MS1
Farahvash, MM1
Moradimogadam, M1
Mohammadzadeh, S1
Hyde, CA1
Missailidis, S1
Green, DL1
Karpatkin, S1
Khaidakov, M1
Szwedo, J1
Mitra, S1
Mehta, JL1
Goertz, O1
Ring, A1
Buschhaus, B1
Hirsch, T1
Daigeler, A1
Steinstraesser, L1
Steinau, HU1
Langer, S1
Gravitz, L1
Markens, BA1
Belotti, A1
Elli, E1
Speranza, T1
Lanzi, E1
Pioltelli, P1
Pogliani, E1
Ma, C1
Wang, Q1
Man, Y1
Kemmner, W1
Brown, JR2
Seed, MP2
Willoughby, DA2
Freeman, AF1
Crawford, SE1
Finn, LS1
López-Andreu, JA1
Ferrando-Monleón, S1
Pérez-Tamarit, D1
Cornwall, ML1
Shulman, ST1
Rowley, AH1
Shtivelband, MI1
Juneja, HS1
Lee, S1
Wu, KK1
Garcia-Porrua, C1
Pego-Reigosa, R1
Armesto, V1
Gonzalez-Gay, MA1
Yoshida, S1
Amano, H1
Hayashi, I1
Kitasato, H1
Kamata, M1
Inukai, M1
Yoshimura, H1
Majima, M1
Pourati, I1
Kimmelstiel, C1
Rand, W1
Karas, RH1
Rhee, JS1
Black, M1
Schubert, U1
Fischer, S1
Morgenstern, E1
Hammes, HP1
Preissner, KT1
Claeys, MJ1
Van der Planken, MG1
Bosmans, JM1
Michiels, JJ1
Vertessen, F1
Van Der Goten, P1
Wuyts, FL1
Vrints, CJ1
Ghezzo, F1
Cesano, L1
Mognetti, B1
Pesce, E1
Pirro, E1
Corvetti, G1
Berta, GN1
Zingaro, B1
Di Carlo, F1
Thiex, R1
Küker, W1
Jungbluth, P1
Kayser, C1
Müller, HD1
Rohde, I1
Gilsbach, JM1
Rohde, V1
Cezar-de-Mello, PF1
Nascimento-Silva, V1
Villela, CG1
Fierro, IM1
Narvaez, I1
Sagastagoitia, JD1
Vacas, M1
Saez, Y1
Lafita, M1
Monica, S1
de Lafuente, JP1
Molinero, E1
Iriarte, JA1
Holmes, CE1
Huang, JC1
Pace, TR1
Howard, AB1
Muss, HB1
McAuslan, BR1
Gole, GA1
Kamiński, MJ1
Majewski, S1
Kamińska, G1
Bem, W1
Szmurło, A1
Peterson, HI1
Valone, J1
Yoshizumi, MO1
Townsend-Pico, W1
Freemantle, CN1
Alam, CA1
Colville-Nash, PR1
Papworth, JL1
Somerville, KW1
Horan, AH1
Fong, DS1
Barton, FB1
Bresnick, GH1
Shiff, SJ1
Yogo, K1
Shimokawa, H1
Funakoshi, H1
Kandabashi, T1
Miyata, K1
Okamoto, S1
Egashira, K1
Huang, P1
Akaike, T1
Takeshita, A1
Samaniego, F1
Pati, S1
Karp, JE1
Prakash, O1
Bose, D1
Ma, L1
Elliott, SN1
Cirino, G1
Buret, A1
Ignarro, LJ1
Wallace, JL1
Bing, RJ1
Narumiya, S1
FitzGerald, GA1
Patz, A1
Finkelstein, D1
Fine, SL1
Murphy, RP1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Mobilization of Endothelial Progenitor Cells Following Alcohol Septal Ablation in Hypertrophic Obstructive Cardiomyopathy: Randomized Controlled Trial of Aspirin[NCT02674958]Phase 36 participants (Actual)Interventional2016-05-31Terminated (stopped due to Covid-19 pandemic)
Gastrointestinal Ulceration in Patients on Dual Antiplatelet Therapy After Percutaneous Coronary Intervention[NCT00413309]30 participants (Anticipated)Interventional2006-04-30Completed
Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer[NCT02418312]228 participants (Actual)Interventional2012-01-31Completed
Pantoprazole Versus Famotidine for the Prevention of Recurrent Peptic Ulcers in Thienopyridine Users - a Double-blind Randomized Controlled Trial[NCT02551744]101 participants (Actual)Interventional2012-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Healed Peptic Ulcer

Follow-up endoscopy was performed at the end of the 6th month (NCT02418312)
Timeframe: 6 months

Interventionparticipants (Number)
Histamine-2 Receptor Antagonist Group106
Placebo Group101

Number of Participants With Ulcer Recurrence

Follow-up endoscopy was performed at the end of the 6th month (NCT02551744)
Timeframe: six month

Interventionparticipants (Number)
Proton Pump Inhibitor Group1
Histamine-2 Receptor Antagonist Group7

Reviews

9 reviews available for aspirin and Angiogenesis, Pathologic

ArticleYear
Mechanisms of the antiangiogenic effects of aspirin in cancer.
    European journal of pharmacology, 2021, May-05, Volume: 898

    Topics: Angiogenesis Inhibitors; Animals; Aspirin; Humans; Neoplasms; Neovascularization, Pathologic; Signal

2021
Chemopreventive effects of aspirin at a glance.
    Biochimica et biophysica acta, 2015, Volume: 1855, Issue:2

    Topics: Anticarcinogenic Agents; Aspirin; Cyclooxygenase 1; Cyclooxygenase Inhibitors; DNA Damage; Humans; N

2015
Platelets at the interface of thrombosis, inflammation, and cancer.
    Blood, 2015, Jul-30, Volume: 126, Issue:5

    Topics: Animals; Anticarcinogenic Agents; Aspirin; Blood Platelets; Cell Death; Cell Proliferation; Cell-Der

2015
Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis.
    International immunopharmacology, 2009, Volume: 9, Issue:6

    Topics: Animals; Antineoplastic Agents; Arachidonic Acid; Aspirin; Cell Cycle Proteins; Cell Proliferation;

2009
Effect of cancer on platelets.
    Cancer treatment and research, 2009, Volume: 148

    Topics: Animals; Aspirin; Blood Platelets; Cell Adhesion; Clinical Trials as Topic; Endothelium, Vascular; H

2009
Cardiovascular medications in angiogenesis--how to avoid the sting in the tail.
    International journal of cancer, 2012, Sep-15, Volume: 131, Issue:6

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Aspirin; Calcium Cha

2012
Proliferative diabetic retinopathy and patient age: presentation, prognosis, and management.
    International ophthalmology clinics, 1984,Winter, Volume: 24, Issue:4

    Topics: Adolescent; Adult; Age Factors; Anticoagulants; Aspirin; Diabetes Mellitus, Type 1; Diabetic Retinop

1984
Myocardial ischemia and infarction: growth of ideas.
    Cardiovascular research, 2001, Volume: 51, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; Cyclooxygenase Inhibit

2001
Genetic and pharmacological analysis of prostanoid receptor function.
    The Journal of clinical investigation, 2001, Volume: 108, Issue:1

    Topics: Animals; Aspirin; Biological Transport; Bone Resorption; Cell Nucleus; Colonic Neoplasms; Cyclooxyge

2001

Trials

4 trials available for aspirin and Angiogenesis, Pathologic

ArticleYear
Long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion.
    Archives of Iranian medicine, 2008, Volume: 11, Issue:5

    Topics: Aspirin; Dalteparin; Female; Fibrinolytic Agents; Humans; Iris; Male; Middle Aged; Neovascularizatio

2008
Does pre-treatment with aspirin and loading dose clopidogrel obviate the need for glycoprotein IIb/IIIa antagonists during elective coronary stenting? A focus on peri-procedural myonecrosis.
    European heart journal, 2005, Volume: 26, Issue:6

    Topics: Abciximab; Aged; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Angiography; Coronary Diseas

2005
Tamoxifen and aromatase inhibitors differentially affect vascular endothelial growth factor and endostatin levels in women with breast cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, May-15, Volume: 14, Issue:10

    Topics: Adult; Antineoplastic Agents; Aromatase Inhibitors; Aspirin; Blood Platelets; Breast Neoplasms; Endo

2008
Impaired color vision associated with diabetic retinopathy: Early Treatment Diabetic Retinopathy Study Report No. 15.
    American journal of ophthalmology, 1999, Volume: 128, Issue:5

    Topics: Adolescent; Adult; Aged; Aging; Aspirin; Color; Color Perception; Diabetic Retinopathy; Discriminati

1999

Other Studies

46 other studies available for aspirin and Angiogenesis, Pathologic

ArticleYear
Aspirin use and prostate tumor angiogenesis.
    Cancer causes & control : CCC, 2022, Volume: 33, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Follow-Up Studies; Humans; Male; Neovascularizatio

2022
Molecular Ultrasound Imaging Depicts the Modulation of Tumor Angiogenesis by Acetylsalicylic Acid.
    International journal of molecular sciences, 2023, Apr-11, Volume: 24, Issue:8

    Topics: Animals; Aspirin; Mice; Neoplasms; Neovascularization, Pathologic; Ultrasonography; Vascular Endothe

2023
Platelets disrupt vasculogenic mimicry by cancer cells.
    Scientific reports, 2020, 04-03, Volume: 10, Issue:1

    Topics: Animals; Apoptosis; Aspirin; Blood Platelets; Breast Neoplasms; Cell Line, Tumor; Female; Male; Mela

2020
Aspirin inhibits endometrial fibrosis by suppressing the TGF‑β1‑Smad2/Smad3 pathway in intrauterine adhesions.
    International journal of molecular medicine, 2020, Volume: 45, Issue:5

    Topics: Adult; Aspirin; Endometrium; Estrogens; Female; Fibrosis; Humans; Neovascularization, Pathologic; Re

2020
Aspirin alleviates skin inflammation and angiogenesis in rosacea.
    International immunopharmacology, 2021, Volume: 95

    Topics: Animals; Anti-Inflammatory Agents; Antimicrobial Cationic Peptides; Aspirin; Cathelicidins; Dermatit

2021
Aspirin Inhibits Cancer Metastasis and Angiogenesis via Targeting Heparanase.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2017, Oct-15, Volume: 23, Issue:20

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Aspirin; Cell Line, Tumor; Chick Embryo; Di

2017
Chemoprevention by artesunate in a preclinical model of colorectal cancer involves down regulation of β-catenin, suppression of angiogenesis, cellular proliferation and induction of apoptosis.
    Chemico-biological interactions, 2017, Dec-25, Volume: 278

    Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Apoptosis; Artemisinins; Artesunate; Aspirin; b

2017
Therapy for antiphospholipid miscarriages: Throwing the baby out with the bathwater?
    American journal of reproductive immunology (New York, N.Y. : 1989), 2018, Volume: 79, Issue:3

    Topics: Abortion, Habitual; Antibodies, Antiphospholipid; Aspirin; Drug Therapy, Combination; Endometrium; E

2018
Aspirin Disrupts the Crosstalk of Angiogenic and Inflammatory Cytokines between 4T1 Breast Cancer Cells and Macrophages.
    Mediators of inflammation, 2018, Volume: 2018

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Cell Line, Tumor

2018
Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis.
    Blood advances, 2019, 01-22, Volume: 3, Issue:2

    Topics: Aspirin; Blood Platelets; Breast Neoplasms; Cell Line, Tumor; Cytokines; Female; Humans; Neoplasm Me

2019
Impact of acetylsalicylic acid on tumor angiogenesis and lymphangiogenesis through inhibition of VEGF signaling in a murine sarcoma model.
    Oncology reports, 2013, Volume: 29, Issue:5

    Topics: Animals; Aspirin; Fluorouracil; Lymphangiogenesis; Lymphatic Vessels; Male; Mice; Neovascularization

2013
Platelet-mediated angiogenesis is independent of VEGF and fully inhibited by aspirin.
    British journal of pharmacology, 2013, Volume: 170, Issue:2

    Topics: Aspirin; Blood Platelets; Cell Proliferation; Endostatins; Endothelial Cells; Humans; In Vitro Techn

2013
Cathelicidin LL-37 induces angiogenesis via PGE2-EP3 signaling in endothelial cells, in vivo inhibition by aspirin.
    Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimicrobial Cationic Peptides; Aspirin; Calcium; Cathelic

2013
Angiogenic impairment of the vascular endothelium: a novel mechanism and potential therapeutic target in muscular dystrophy.
    Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:12

    Topics: Animals; Apoptosis; Aspirin; Carcinoma, Lewis Lung; Caveolin 1; Cell Movement; Cell Proliferation; C

2013
Neurovascular protection of cilostazol in stroke-prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation.
    Journal of neuroscience research, 2014, Volume: 92, Issue:3

    Topics: Animals; Antigens; Aspirin; Cerebrovascular Circulation; Cilostazol; Clopidogrel; Disease Models, An

2014
Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1.
    Inflammopharmacology, 2014, Volume: 22, Issue:5

    Topics: Administration, Oral; Angiopoietin-1; Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Ex

2014
Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016, Volume: 30, Issue:12

    Topics: Aspirin; Blood Platelets; Cells, Cultured; Cyclooxygenase 1; Eicosanoids; Endothelium; Humans; Hydro

2016
Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer.
    Molecular cancer therapeutics, 2016, Volume: 15, Issue:12

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Biomarkers; Cell Line,

2016
NO-donating aspirin inhibits angiogenesis by suppressing VEGF expression in HT-29 human colon cancer mouse xenografts.
    Carcinogenesis, 2008, Volume: 29, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; HT29 Cells; Humans; Im

2008
Angiostatic effects of aspirin in hypoxia-reoxygenation are linked to modulation of TGFβ1 signaling.
    Journal of cardiovascular pharmacology and therapeutics, 2011, Volume: 16, Issue:1

    Topics: Angiogenesis Inhibitors; Aspirin; Atherosclerosis; Cell Hypoxia; Cell Migration Assays; Cells, Cultu

2011
Influence of anti-inflammatory and vasoactive drugs on microcirculation and angiogenesis after burn in mice.
    Burns : journal of the International Society for Burn Injuries, 2011, Volume: 37, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Burns; Disease Models, Animal; Endothelium; Injections,

2011
Chemoprevention: First line of defence.
    Nature, 2011, Mar-24, Volume: 471, Issue:7339

    Topics: Animals; Aspirin; Celecoxib; Clinical Trials, Phase II as Topic; Colonic Neoplasms; Cyclooxygenase I

2011
Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis.
    Blood, 2011, Aug-04, Volume: 118, Issue:5

    Topics: Adenosine Diphosphate; Angiogenesis Modulating Agents; Aspirin; Blood Platelets; Breast Neoplasms; C

2011
Circulating endothelial cells and endothelial activation in essential thrombocythemia: results from CD146+ immunomagnetic enrichment--flow cytometry and soluble E-selectin detection.
    American journal of hematology, 2012, Volume: 87, Issue:3

    Topics: Alkylating Agents; Anticoagulants; Aspirin; CD146 Antigen; Drug Therapy, Combination; E-Selectin; En

2012
Relationship between apoptosis, angiogenesis and colon-26 tumour growth after oral NSAID-treatment.
    Advances in experimental medicine and biology, 2002, Volume: 507

    Topics: Adenocarcinoma; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; A

2002
Inflammatory pulmonary nodules in Kawasaki disease.
    Pediatric pulmonology, 2003, Volume: 36, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Immunoglobulin A; Immunoglobulins, Intrave

2003
Aspirin and salicylate inhibit colon cancer medium- and VEGF-induced endothelial tube formation: correlation with suppression of cyclooxygenase-2 expression.
    Journal of thrombosis and haemostasis : JTH, 2003, Volume: 1, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cells, Cultured; Collagen; Colo

2003
Neovascularization around the optic nerve in giant cell arteritis.
    Arthritis and rheumatism, 2003, Oct-15, Volume: 49, Issue:5

    Topics: Aged; Aspirin; Giant Cell Arteritis; Humans; Magnetic Resonance Imaging; Male; Neovascularization, P

2003
COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo.
    Laboratory investigation; a journal of technical methods and pathology, 2003, Volume: 83, Issue:10

    Topics: Animals; Antibodies, Blocking; Aspirin; Benzenesulfonates; Carcinoma, Lewis Lung; Cyclooxygenase Inh

2003
Statin use is associated with enhanced collateralization of severely diseased coronary arteries.
    American heart journal, 2003, Volume: 146, Issue:5

    Topics: Aged; Aspirin; Atorvastatin; Calcium Channels; Collateral Circulation; Coronary Angiography; Coronar

2003
The functional role of blood platelet components in angiogenesis.
    Thrombosis and haemostasis, 2004, Volume: 92, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Component Transfusion; Blood Platel

2004
Salicylate inhibition of rat mammary carcinogenesis and angiogenesis in female rat compatible with misoprostol administration.
    International journal of oncology, 2005, Volume: 26, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Transformation, Neoplastic; Disease

2005
Minor inflammation after surgical evacuation compared with fibrinolytic therapy of experimental intracerebral hemorrhages.
    Neurological research, 2005, Volume: 27, Issue:5

    Topics: Analysis of Variance; Animals; Aspirin; Blood Transfusion, Autologous; Cerebral Hemorrhage; Confiden

2005
Aspirin-triggered Lipoxin A4 inhibition of VEGF-induced endothelial cell migration involves actin polymerization and focal adhesion assembly.
    Oncogene, 2006, Jan-05, Volume: 25, Issue:1

    Topics: Actins; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Adhesion; Cell Movement; Cells, Cultu

2006
Prevalence and biologic profile of aspirin resistance in patients with angiographically proven coronary artery disease.
    Thrombosis research, 2007, Volume: 120, Issue:5

    Topics: Aged; Apolipoproteins B; Aspirin; Blood Platelets; Coronary Artery Disease; Drug Resistance; Epineph

2007
Cellular and molecular mechanisms in angiogenesis.
    Transactions of the ophthalmological societies of the United Kingdom, 1980, Volume: 100, Issue:3

    Topics: Animals; Anterior Chamber; Aspirin; Carcinoma 256, Walker; Cell Movement; Copper; Copper Sulfate; Co

1980
Protease-mediated enhancement of lymphocyte-induced angiogenesis in X-ray irradiated mice.
    International journal of radiation biology and related studies in physics, chemistry, and medicine, 1983, Volume: 43, Issue:2

    Topics: Aminocaproic Acid; Animals; Aprotinin; Aspirin; Cortisone; Dose-Response Relationship, Radiation; Fe

1983
Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat.
    Invasion & metastasis, 1983, Volume: 3, Issue:3

    Topics: Animals; Aspirin; Diclofenac; Fibrosarcoma; Indomethacin; Liver Neoplasms, Experimental; Neoplasm Tr

1983
Essential thrombocythemia and central retinal vein occlusion with neovascular glaucoma.
    American journal of ophthalmology, 1996, Volume: 121, Issue:6

    Topics: Adrenergic beta-Antagonists; Antisickling Agents; Aspirin; Bone Marrow; Fluorescein Angiography; Fun

1996
Apoptosis induction and inhibition of colon-26 tumour growth and angiogenesis: findings on COX-1 and COX-2 inhibitors in vitro & in vivo and topical diclofenac in hyaluronan.
    Advances in experimental medicine and biology, 1997, Volume: 433

    Topics: Administration, Topical; Animals; Apoptosis; Aspirin; Cell Division; Cell Survival; Colonic Neoplasm

1997
Re: Advances in angiogenesis research: relevance to urological oncology.
    The Journal of urology, 1998, Volume: 160, Issue:1

    Topics: Aspirin; Humans; Male; Neovascularization, Pathologic; Prostatic Neoplasms; Research

1998
Aspirin for cancer.
    Nature medicine, 1999, Volume: 5, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Humans; Neopla

1999
Different vasculoprotective roles of NO synthase isoforms in vascular lesion formation in mice.
    Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:11

    Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Aspirin; Carotid Arteries; Female; F

2000
Human herpesvirus 8 K1-associated nuclear factor-kappa B-dependent promoter activity: role in Kaposi's sarcoma inflammation?
    Journal of the National Cancer Institute. Monographs, 2001, Issue:28

    Topics: Amino Acid Motifs; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chlorocebus aethiops;

2001
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, May-22, Volume: 98, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood

2001
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, May-22, Volume: 98, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood

2001
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, May-22, Volume: 98, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood

2001
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, May-22, Volume: 98, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood

2001
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, May-22, Volume: 98, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood

2001
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, May-22, Volume: 98, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood

2001
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, May-22, Volume: 98, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood

2001
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, May-22, Volume: 98, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood

2001
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, May-22, Volume: 98, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood

2001
The role of fluorescein angiography in national collaborative studies.
    Ophthalmology, 1986, Volume: 93, Issue:11

    Topics: Aspirin; Choroid; Clinical Trials as Topic; Diabetic Retinopathy; Fluorescein Angiography; Forecasti

1986