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aspirin and Angina Pectoris, Variant

aspirin has been researched along with Angina Pectoris, Variant in 23 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Angina Pectoris, Variant: A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.

Research Excerpts

ExcerptRelevanceReference
"796 men with unstable coronary artery disease (unstable angina or non-Q-wave myocardial infarction [MI] ), were randomised to double-blind placebo-controlled treatment with oral aspirin 75 mg/day and/or 5 days of intermittent intravenous heparin."9.06Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. The RISC Group. ( , 1990)
" Although a 150 mg dose of aspirin reduced urinary dinor-TxB2 levels by over 75 per cent, it had no effect on the course of the chronic recurrent form of angina pectoris due to vasospasm ("vasotonic angina")."9.05Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials. ( FitzGerald, GA; Friesinger, GC; Maas, RL; Oates, JA; Roberts, LJ; Robertson, D; Robertson, RM, 1981)
"In vasospastic angina without significant coronary artery stenosis, patients taking low-dose aspirin are at higher risk of MACE, driven primarily by tendency toward rehospitalization."7.83Clinical implications of low-dose aspirin on vasospastic angina patients without significant coronary artery stenosis; a propensity score-matched analysis. ( Ahn, J; Carriere, KC; Cho, SW; Choi, JH; Choi, SH; Gwag, HB; Gwon, HC; Hahn, JY; Lee, da H; Lee, SH; Lim, AY; Oh, MS; Park, TK; Seong, CS; Song, YB; Yang, JH, 2016)
"A 42-year-old man with aspirin-induced asthma also developed Prinzmetal's variant angina shortly after aspirin ingestion suggesting a possible physiologic relationship between bronchospasm and coronary spasm in aspirin-sensitive patients."7.67Is coronary arterial spasm part of the aspirin-induced asthma syndrome? ( Habbab, MA; Haft, JI; Szwed, SA, 1986)
"796 men with unstable coronary artery disease (unstable angina or non-Q-wave myocardial infarction [MI] ), were randomised to double-blind placebo-controlled treatment with oral aspirin 75 mg/day and/or 5 days of intermittent intravenous heparin."5.06Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. The RISC Group. ( , 1990)
" Although a 150 mg dose of aspirin reduced urinary dinor-TxB2 levels by over 75 per cent, it had no effect on the course of the chronic recurrent form of angina pectoris due to vasospasm ("vasotonic angina")."5.05Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials. ( FitzGerald, GA; Friesinger, GC; Maas, RL; Oates, JA; Roberts, LJ; Robertson, D; Robertson, RM, 1981)
"In vasospastic angina without significant coronary artery stenosis, patients taking low-dose aspirin are at higher risk of MACE, driven primarily by tendency toward rehospitalization."3.83Clinical implications of low-dose aspirin on vasospastic angina patients without significant coronary artery stenosis; a propensity score-matched analysis. ( Ahn, J; Carriere, KC; Cho, SW; Choi, JH; Choi, SH; Gwag, HB; Gwon, HC; Hahn, JY; Lee, da H; Lee, SH; Lim, AY; Oh, MS; Park, TK; Seong, CS; Song, YB; Yang, JH, 2016)
"A 42-year-old man with aspirin-induced asthma also developed Prinzmetal's variant angina shortly after aspirin ingestion suggesting a possible physiologic relationship between bronchospasm and coronary spasm in aspirin-sensitive patients."3.67Is coronary arterial spasm part of the aspirin-induced asthma syndrome? ( Habbab, MA; Haft, JI; Szwed, SA, 1986)
" Aspirin alone appears to be safe for use in those patients."1.51Clopidogrel plus Aspirin Use is Associated with Worse Long-Term Outcomes, but Aspirin Use Alone is Safe in Patients with Vasospastic Angina: Results from the VA-Korea Registry, A Prospective Multi-Center Cohort. ( Baek, SH; Cho, SS; Gwon, HC; Han, SH; Her, SH; Jo, SH; Kim, SE; Lee, BK; Lee, KY; Lee, MH; Park, KH; Rha, SW; Seo, WW; Suh, JW; Yang, TH, 2019)
"Prednisolone was therefore seen to be effective for treating variant angina that manifested as a non-respiratory tract symptom of aspirin-exacerbated respiratory disease."1.43[A CASE OF ASPIRIN-EXACERBATED RESPIRATORY DISEASE COMPLICATED BY REFRACTORY VARIANT ANGINA, WHICH SHOWED EXCELLENT RESPONSE TO STEROID TREATMENT]. ( Naito, T, 2016)
"The mean degree of stenosis was reduced from 77 +/- 12% to 29 +/- 15% and the mean systolic pressure gradient from 78 +/- 18 to 25 +/- 9 mmHg."1.27Role of percutaneous transluminal coronary angioplasty in patients with variant angina and coexistent coronary stenosis refractory to maximal medical therapy. ( Brücke, P; Herbinger, W; Leisch, F, 1984)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199012 (52.17)18.7374
1990's2 (8.70)18.2507
2000's3 (13.04)29.6817
2010's5 (21.74)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Cho, SS1
Jo, SH1
Han, SH1
Lee, KY1
Her, SH1
Lee, MH1
Seo, WW1
Kim, SE1
Yang, TH1
Park, KH2
Suh, JW1
Lee, BK1
Rha, SW1
Gwon, HC2
Baek, SH1
Agrawal, Y1
Ponna, PK1
Halabi, AR1
Aloka, F1
Naito, T1
Lim, AY1
Park, TK1
Cho, SW1
Oh, MS1
Lee, da H1
Seong, CS1
Gwag, HB1
Yang, JH1
Song, YB1
Hahn, JY1
Choi, JH1
Lee, SH1
Ahn, J1
Carriere, KC1
Choi, SH1
Wang, AC1
Chen, SJ1
Lee, PC1
Hwang, BT1
Tsai, MC1
Soysal, D1
Karakuş, V1
Yavaş, HH1
Biçeroğlu, S1
Köseoğlu, M1
Yeşil, M1
Kim, MC1
Ahn, Y1
Sim, DS1
Yoon, NS1
Yoon, HJ1
Kim, KH1
Hong, YJ1
Park, HW1
Kim, JH1
Jeong, MH1
Cho, JG1
Park, JC1
Kang, JC1
Seniuk, W1
Mularek-Kubzdela, T1
Grygier, M1
Grajek, S1
Cieśliński, A1
Dobarro, D1
Gómez-Rubín, MC1
Sánchez-Recalde, A1
Moreno, R1
Leisch, F1
Herbinger, W1
Brücke, P1
Gunby, P1
Willerson, JT1
Campbell, WB1
Winniford, MD1
Schmitz, J1
Apprill, P1
Firth, BG1
Ashton, J1
Smitherman, T1
Bush, L1
Buja, LM1
Lewy, RI1
Al-Abbasi, AH1
Miwa, K2
Kambara, H2
Kawai, C2
Handin, RI1
Alexander, RW1
Robertson, RM1
Robertson, D1
Roberts, LJ1
Maas, RL1
FitzGerald, GA1
Friesinger, GC1
Oates, JA1
Takatsu, F1
Nishiyama, A1
Shiga, Y1
Watarai, M1
Shimizu, S1
Arrigo, F1
Coglitore, S1
Virga, T1
Giannetto, M1
Bramanti, B1
Melluso, C1
Consolo, F1
De Servi, S1
Ferrario, M1
Rondanelli, R1
Corsico, G1
Poma, E1
Ghio, S1
Mussini, A1
Angoli, L1
Bramucci, E1
Bré, E1
Habbab, MA1
Szwed, SA1
Haft, JI1

Trials

5 trials available for aspirin and Angina Pectoris, Variant

ArticleYear
Aspirin curbs MIs in unstable angina cases.
    JAMA, 1983, Jan-07, Volume: 249, Issue:1

    Topics: Angina Pectoris, Variant; Aspirin; Clinical Trials as Topic; Coronary Vasospasm; Double-Blind Method

1983
Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials.
    The New England journal of medicine, 1981, Apr-23, Volume: 304, Issue:17

    Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Arteries; Aspirin; Clinical Trials as Topic; Coron

1981
Exercise-induced angina provoked by aspirin administration in patients with variant angina.
    The American journal of cardiology, 1981, Volume: 47, Issue:6

    Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Aspirin; Coronary Angiography; Electrocardio

1981
Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. The RISC Group.
    Lancet (London, England), 1990, Oct-06, Volume: 336, Issue:8719

    Topics: Administration, Oral; Aged; Angina Pectoris, Variant; Aspirin; Drug Administration Schedule; Electro

1990
Coronary vasoconstrictor response to cold pressor test in variant angina: lack of relation to intracoronary thromboxane concentrations.
    American heart journal, 1987, Volume: 114, Issue:3

    Topics: Adult; Angina Pectoris, Variant; Angiography; Aorta; Aspirin; Blood Pressure; Cold Temperature; Coro

1987

Other Studies

18 other studies available for aspirin and Angina Pectoris, Variant

ArticleYear
Clopidogrel plus Aspirin Use is Associated with Worse Long-Term Outcomes, but Aspirin Use Alone is Safe in Patients with Vasospastic Angina: Results from the VA-Korea Registry, A Prospective Multi-Center Cohort.
    Scientific reports, 2019, 11-28, Volume: 9, Issue:1

    Topics: Aged; Angina Pectoris, Variant; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Mal

2019
Prinzmetal angina: echocardiographic captured and angiographically proven without provocative testing.
    BMJ case reports, 2020, Sep-13, Volume: 13, Issue:9

    Topics: Angina Pectoris, Variant; Aspirin; Calcium Channel Blockers; Cardiac Catheterization; Coronary Angio

2020
[A CASE OF ASPIRIN-EXACERBATED RESPIRATORY DISEASE COMPLICATED BY REFRACTORY VARIANT ANGINA, WHICH SHOWED EXCELLENT RESPONSE TO STEROID TREATMENT].
    Arerugi = [Allergy], 2016, Volume: 65, Issue:2

    Topics: Angina Pectoris, Variant; Aspirin; Drug Hypersensitivity; Female; Humans; Middle Aged; Prednisolone;

2016
Clinical implications of low-dose aspirin on vasospastic angina patients without significant coronary artery stenosis; a propensity score-matched analysis.
    International journal of cardiology, 2016, Oct-15, Volume: 221

    Topics: Angina Pectoris, Variant; Aspirin; Coronary Angiography; Coronary Stenosis; Coronary Vasospasm; Coro

2016
Variant angina in an adolescent coexisting with intermittent Wolff-Parkinson-White syndrome.
    The American journal of emergency medicine, 2008, Volume: 26, Issue:8

    Topics: Adolescent; Angina Pectoris, Variant; Aspirin; Calcium Channel Blockers; Coronary Angiography; Dilti

2008
C-reactive protein in unstable angina pectoris and its relation to coronary angiographic severity and diffusion scores of coronary lesions.
    Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2010, Volume: 10, Issue:5

    Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris, Variant; Aspirin; Biomarkers; C-Reactive Protein

2010
Clinical outcomes of low-dose aspirin administration in patients with variant angina pectoris.
    International journal of cardiology, 2013, Sep-01, Volume: 167, Issue:5

    Topics: Adult; Aged; Angina Pectoris, Variant; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Fol

2013
Cardiac arrest related to coronary spasm in patients with variant angina: a three-case study.
    Journal of internal medicine, 2002, Volume: 252, Issue:4

    Topics: Amiodarone; Angina Pectoris, Variant; Anti-Arrhythmia Agents; Aspirin; Calcium Channel Blockers; Car

2002
[Severe vasoespasm during coronary angiograms in a patient with Prinzmetal syndrome].
    Medicina clinica, 2008, Mar-08, Volume: 130, Issue:8

    Topics: Administration, Cutaneous; Administration, Oral; Angina Pectoris, Variant; Aspirin; Cardiovascular A

2008
Role of percutaneous transluminal coronary angioplasty in patients with variant angina and coexistent coronary stenosis refractory to maximal medical therapy.
    Clinical cardiology, 1984, Volume: 7, Issue:12

    Topics: Adult; Angina Pectoris, Variant; Angiography; Angioplasty, Balloon; Aspirin; Constriction, Pathologi

1984
Conversion from chronic to acute coronary artery disease: speculation regarding mechanisms.
    The American journal of cardiology, 1984, Dec-01, Volume: 54, Issue:10

    Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Angina, Unstable; Aorta; Aspirin; Blood Pres

1984
Role of thromboxanes in vasotonic versus vaso-occlusive angina.
    Archives des maladies du coeur et des vaisseaux, 1983, Volume: 76 Spec No

    Topics: Angina Pectoris; Angina Pectoris, Variant; Arterial Occlusive Diseases; Aspirin; Blood Platelets; Ca

1983
Salicylate-induced variant angina.
    American heart journal, 1983, Volume: 106, Issue:6

    Topics: Angina Pectoris, Variant; Aspirin; Humans

1983
Effect of aspirin in large doses on attacks of variant angina.
    American heart journal, 1983, Volume: 105, Issue:2

    Topics: Adult; Aged; Angina Pectoris, Variant; Aspirin; Coronary Vasospasm; Diltiazem; Electrocardiography;

1983
Humoral heartache -- do platelets have a role?
    The New England journal of medicine, 1981, Apr-23, Volume: 304, Issue:17

    Topics: Angina Pectoris; Angina Pectoris, Variant; Animals; Aspirin; Blood Platelets; Coronary Circulation;

1981
Long-term follow-up of coronary narrowing with spasm.
    International journal of cardiology, 1994, Volume: 47, Issue:1 Suppl

    Topics: Angina Pectoris, Variant; Aspirin; Coronary Angiography; Coronary Artery Disease; Coronary Vasospasm

1994
[Prinzmetal's angina. Considerations on a clinical case].
    Bollettino della Societa italiana di cardiologia, 1977, Volume: 22, Issue:3

    Topics: Adrenergic beta-Antagonists; Adult; Angina Pectoris; Angina Pectoris, Variant; Aspirin; Electrocardi

1977
Is coronary arterial spasm part of the aspirin-induced asthma syndrome?
    Chest, 1986, Volume: 90, Issue:1

    Topics: Adult; Angina Pectoris, Variant; Aspirin; Asthma; Coronary Vasospasm; Electrocardiography; Humans; M

1986