Page last updated: 2024-10-22

aspirin and Angina, Unstable

aspirin has been researched along with Angina, Unstable in 498 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Angina, Unstable: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"Among patients with unstable angina or myocardial infarction without ST-segment elevation, prasugrel did not significantly reduce the frequency of the primary end point, as compared with clopidogrel, and similar risks of bleeding were observed."9.16Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. ( Ardissino, D; Armstrong, PW; Aylward, PE; Bhatt, DL; Boden, WE; Brown, EB; Cinteză, M; Clemmensen, P; Corbalan, R; Cornel, JH; Dalby, AJ; Fox, KA; Gasparovic, V; Goodman, SG; Gottlieb, S; Goudev, AR; Gurbel, PA; Hamm, C; Hochman, JS; Huber, K; Leiva-Pons, JL; Lokhnygina, Y; Martinez, F; McGuire, DK; McLendon, RC; Merkely, B; Nicolau, JC; Ohman, EM; Oto, A; Parkhomenko, A; Pavlides, G; Prabhakaran, D; Roe, MT; Ruzyllo, W; Topacio, GO; Tseng, CD; White, HD; Winters, KJ, 2012)
"The trial was terminated prematurely after recruitment of 7392 patients because of an increase in major bleeding events with apixaban in the absence of a counterbalancing reduction in recurrent ischemic events."9.15Apixaban with antiplatelet therapy after acute coronary syndrome. ( Alexander, JH; Atar, D; Bhatt, DL; Cools, F; Cornel, JH; Darius, H; De Caterina, R; Diaz, R; Flather, M; Geraldes, M; Goodman, S; Harrington, RA; He, Y; Huber, K; Husted, SE; James, S; Jansky, P; Keltai, M; Kilaru, R; Lawrence, J; Leiva-Pons, JL; Liaw, D; Lopes, RD; Lopez-Sendon, J; Mohan, P; Ogawa, H; Pais, P; Parkhomenko, A; Ruda, M; Ruzyllo, W; Verheugt, FW; Vinereanu, D; Wallentin, L; White, H, 2011)
" Orbofiban, despite no significant excess risk of ICH, was not effective in preventing ischemic stroke or TIA."9.12Risk factors for stroke after acute coronary syndromes in the Orbofiban in Patients with Unstable Coronary Syndromes--Thrombolysis In Myocardial Infarction (OPUS-TIMI) 16 study. ( Cannon, CP; Feske, SK; Murphy, S; Schwamm, LH; Smith, EE, 2006)
"Patients with high-risk non-ST-segment elevation acute coronary syndromes (NSTE ACS) benefit from the early administration of aspirin, a small molecule glycoprotein IIb/IIIa inhibitor such as eptifibatide, and heparin."9.12Randomized evaluation of the efficacy of enoxaparin versus unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes receiving the glycoprotein IIb/IIIa inhibitor eptifibatide. Long-term results of the Integrilin ( Armstrong, PW; Fitchett, DH; Goodman, SG; Langer, A; Mendelsohn, A; Tan, M, 2006)
"Thrombocytopenia, though uncommon, was associated with orbofiban use and an increased risk of bleeding, but also death and MI."9.12Drug-induced thrombocytopenia and thrombosis: evidence from patients receiving an oral glycoprotein IIb/IIIa inhibitor in the Orbofiban in Patients with Unstable coronary Syndromes- (OPUS-TIMI 16) trial. ( Aster, RH; Brassard, J; Braunwald, E; Cannon, CP; Charlesworth, A; Cooper, R; McCabe, CH; Scirica, BM; Skene, AM, 2006)
" The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial demonstrated the effectiveness of clopidogrel plus acetylsalicylic acid (ASA) compared with ASA alone in reducing cardiovascular events in patients with acute coronary syndromes and, in addition, patients undergoing percutaneous coronary intervention in the Percutaneous Coronary Intervention in CURE (PCI-CURE) trial."9.12Cost-effectiveness of clopidogrel in acute coronary syndromes in Canada: a long-term analysis based on the CURE trial. ( Kolm, P; Mehta, SR; O'Brien, JA; Veledar, E; Weintraub, WS; Yuan, Y, 2007)
"We studied the benefits and risks of adding clopidogrel to different doses of aspirin in the treatment of patients with acute coronary syndrome (ACS)."9.10Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study. ( Commerford, PJ; Diaz, R; Fox, KA; Kopecky, SL; Lewis, BS; Mehta, SR; Peters, RJ; Valentin, V; Yusuf, S; Zhao, F, 2003)
"Aspirin therapy confers conclusive net benefits in the acute phase of evolving myocardial infarction, but no clear evidence of benefit from the long-term use of aspirin after acute myocardial infarction (AMI) has been shown in any single study."9.09Effects of aspirin and trapidil on cardiovascular events after acute myocardial infarction. Japanese Antiplatelets Myocardial Infarction Study (JAMIS) Investigators. ( Hattori, R; Ishikawa, K; Masuda, Y; Miyazaki, S; Motomiya, T; Ogawa, H; Saito, M; Tamura, Y; Tanaka, H; Yamaguchi, T; Yasue, H, 1999)
"Forty-three patients presenting with unstable angina or myocardial infarction were randomised double blind to warfarin [target international normalised ratio (INR), 2."9.09Coronary artery flow ten weeks after myocardial infarction or unstable angina: effects of combined warfarin and aspirin therapy. ( Stewart, RA; Williams, MJ, 1999)
"The rate of death, myocardial infarction, and urgent revascularization at days 8 and 43 after randomization was compared among patients who received aspirin within the week before randomization with those who did not receive aspirin in the TIMI 11B trial."9.09Prior aspirin users with acute non-ST-elevation coronary syndromes are at increased risk of cardiac events and benefit from enoxaparin. ( Antman, EM; Bozovich, GE; Gurfinkel, EP; Marcos, E; Mautner, B; McCabe, CH; Santopinto, J; Torres, V, 2001)
" We evaluated tirofiban, a specific inhibitor of the platelet glycoprotein IIb/IIIa receptor, in the treatment of unstable angina and non-Q-wave myocardial infarction."9.08Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction. ( , 1998)
"The aim of this trial was to compare the efficacy of combination antithrombotic therapy with a prostacyclin-sparing aspirin plus anticoagulation versus conventional aspirin plus anticoagulation, when added to antianginal therapy, in patients with unstable angina or non-Q wave myocardial infarction already being treated with aspirin."9.07Prospective evaluation of a prostacyclin-sparing aspirin formulation and heparin/warfarin in aspirin users with unstable angina or non-Q wave myocardial infarction at rest. The Antithrombotic Therapy in Acute Coronary Syndromes Research Group. ( Adams, PC; Chamberlain, D; Cohen, M; Fox, KA; Fuster, V; Kronmal, R; Parry, G; Wieczorek, I; Xiong, J, 1994)
"This study compared the effects of heparin and aspirin versus aspirin alone on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina."9.07Comparison of the effect of heparin and aspirin versus aspirin alone on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina. ( Cunningham, D; Fox, K; Hendry, G; Holdright, D; Hubbard, W; Patel, D; Sutton, G; Thomas, R, 1994)
"This study documents that heparin prevents myocardial infarction better than aspirin during the acute phase of unstable angina."9.07Aspirin versus heparin to prevent myocardial infarction during the acute phase of unstable angina. ( de Guise, P; Juneau, M; McCans, J; Qiu, S; Théroux, P; Waters, D, 1993)
"In this study, 796 men with unstable coronary artery disease (that is, unstable angina or non-Q wave myocardial infarction) were randomized to double-blind placebo-controlled treatment with aspirin (75 mg/day)."9.07Aspirin (75 mg/day) after an episode of unstable coronary artery disease: long-term effects on the risk for myocardial infarction, occurrence of severe angina and the need for revascularization. Research Group on Instability in Coronary Artery Disease in ( Wallentin, LC, 1991)
"Both experimental and clinical studies suggest that the prehospital administration of aspirin may be beneficial in patients with unstable angina and acute myocardial infarction."8.79Prehospital administration of aspirin in patients with unstable angina and acute myocardial infarction. ( Eisenberg, MJ; Topal, EJ, 1996)
"To estimate the risk of myocardial infarction (MI) and death in patients with unstable angina who are treated with aspirin plus heparin compared with patients treated with aspirin alone."8.79Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina. A meta-analysis. ( Grady, D; Oler, A; Oler, J; Whooley, MA, 1996)
"The use of aspirin and thrombolytic agents in the management of acute myocardial infarction is now accepted as standard clinical practice, but not all patients with heart attack are suitable for such therapy."8.78Aspirin and thrombolytic therapy in the management of acute myocardial infarction. ( Hockings, B, 1990)
"One-year treatment with clopidogrel in addition to aspirin is a cost-effective treatment option for secondary prevention in patients with acute coronary syndrome without ST-segment elevation in Greece."7.78Economic evaluation of clopidogrel in acute coronary syndrome patients without ST-segment elevation in Greece: a cost-utility analysis. ( Fragoulakis, V; Kourlaba, G; Maniadakis, N, 2012)
"In this study, we aimed to assess the factors associated with laboratory-defined aspirin resistance and the relationship of this laboratory-defined aspirin resistance with thrombolysis in myocardial infarction risk score, markers of cardiac necrosis, and inflammatory and thrombotic risk factors in patients with unstable angina or non-ST elevation myocardial infarction."7.75The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes. ( Acikel, S; Aydinalp, A; Bal, U; Kaynar, G; Muderrisoglu, H; Ozin, B; Yildirir, A, 2009)
"Recent studies have suggested that low-dose aspirin has preserved benefit with less bleeding compared with standard-dose aspirin when given with or without clopidogrel in patients with high-risk non-ST-segment elevation acute coronary syndromes (NSTE ACSs)."7.74Patterns of aspirin dosing in non-ST-elevation acute coronary syndromes in the CRUSADE Quality Improvement Initiative. ( Cannon, CP; Gibler, WB; Milford-Beland, S; Ohman, EM; Peterson, ED; Pollack, CV; Roe, MT; Tickoo, S, 2007)
"To compare the efficacy of intravenous versus oral aspirin use in patients with acute coronary syndrome (ACS)."7.74[Efficacy of intravenous aspirin use in patients with acute coronary syndrome]. ( Shen, LH; Yang, M; Zhao, Y, 2007)
"Aspirin has been used for secondary prevention of myocardial infarction (MI) in individuals with coronary disease."7.74Failure of aspirin to prevent myocardial infarction and adverse outcome during follow-up - a large series of all-comers. ( Eskola, M; Karhunen, PJ; Mikkelsson, J; Niemela, K; Nikus, K, 2008)
"Our study demonstrates an increased risk of major bleeding in unselected patients receiving combination therapy with ASA and clopidogrel after UAP or NSTEMI."7.73[Bleeding complications after treatment with clopidogrel and acetylsalicylic acid after acute coronary syndrome]. ( Kjaer, J; Larsen, CH; Mickley, H; Møller, JE; Poulsen, TS, 2006)
"We report a case of a 76-year-old-man who developed spontaneous hemarthrosis of his right knee following clopidogrel-aspirin treatment."7.72Spontaneous hemarthrosis of the knee associated with clopidogrel and aspirin treatment. ( Behrens, P; Bernotat, J; Böhm, S; Gille, J; Löhr, JF, 2003)
"Aspirin is widely used as an antiplatelet drug in patients with coronary heart disease."7.72Unstable angina, stroke, myocardial infarction and death in aspirin non-responders. A prospective, randomized trial. The ASCET (ASpirin non-responsiveness and Clopidogrel Endpoint Trial) design. ( Abdelnoor, M; Arnesen, H; Pettersen, AA; Seljeflot, I, 2004)
"Aspirin's role in the management of suspected myocardial infarction has been well established."7.71A study of the use of aspirin by general practitioners in suspected myocardial infarction. ( O'Shea, EB, 2001)
" The CURE trial shows that clopidogrel in addition to aspirin achieves this double goal, with a 20% relative risk reduction in the primary composite endpoint of cardiovascular death, myocardial infarction or stroke in the first 30 days."7.71[Clopidogrel in acute coronary syndromes with non-ST elevation. Clinical implications of the CURE trial]. ( Valentín, V, 2001)
"SYMPHONY (Sibrafiban versus aspirin to Yield Maximum Protection from ischemic Heart events post-acute cOroNary syndromes) was a randomized, double-blind, aspirin-controlled trial with 2 concentration regimens of sibrafiban, an oral peptidomimetic GP IIb/IIIa antagonist, for long-term treatment instead of aspirin in patients after an ACS."7.70Long-term oral platelet glycoprotein IIb/IIIa receptor antagonism with sibrafiban after acute coronary syndromes: study design of the sibrafiban versus aspirin to yield maximum protection from ischemic heart events post-acute coronary syndromes (SYMPHONY) ( Newby, LK, 1999)
"We conducted a retrospective case-control study to compare the frequency of myocardial infarction (MI) or unstable angina (UA) precipitated by aspirin-induced upper gastrointestinal (GI) bleeding among patients with and without ischemic heart disease(IHD), and to determine whether the risk of MI or UA is related to the hemoglobin level on admission."7.69Low dose aspirin in patients with ischemic heart disease may precipitate secondary myocardial infarction. ( Amital, H; Bar Dayan, Y; Levy, Y; Shoenfeld, Y, 1996)
"We present a series of fifteen patients treated with low dose aspirin for secondary prevention of ischemic heart disease who had upper GI bleeding and were admitted to our hospital because of unstable angina or myocardial infarction."7.69Aspirin for prevention of myocardial infarction. A double-edged sword. ( Amital, H; Bar-Dayan, Y; Levy, Y; Shoenfeld, Y, 1997)
"Platelet functional parameters (platelet aggregation, blood circulating reversibly and irreversibly aggregated platelet complexes, thromboxane B2, 6-keto-PGF1 alpha) were examined in unstable angina treated with aspirin in a daily dose of 320 mg in relation to the outcome of the disease: Group 1, stabilization and Group 2, evolving myocardial infarction."7.68[Development of myocardial infarction in aspirin-treated unstable angina pectoris. Repeated studies of platelet aggregation and of the thromboxane-prostacyclin system]. ( Shalaev, SV, 1992)
"We examined the prevalence and medical treatment of hypertension among 15,904 ACS patients randomized in the SYMPHONY and 2nd SYMPHONY trials."6.71Prevalence and management of hypertension in acute coronary syndrome patients varies by sex: observations from the Sibrafiban versus aspirin to Yield Maximum Protection from ischemic Heart events postacute cOroNary sYndromes (SYMPHONY) randomized clinical ( Armstrong, PW; Aylward, PE; Bhapkar, MV; Frazier, CG; Klein, WW; Kristinsson, A; McGuire, DK; Newby, LK; Sadowski, Z; Shah, SH; Weaver, WD, 2005)
"When ticlopidine was given for 72 hours, TF levels were similar to normal laboratory values both in stable and unstable patients."6.69Effect of aspirin and ticlopidine on plasma tissue factor levels in stable and unstable angina pectoris. ( Ariëns, RA; Bernies, M; Bossi, IM; Brambilla, GM; Donatelli, F; Fajadet, J; Gregorini, L; Marco, I; Marco, J; Mari, D; Romano, SM; Somalvico, F, 2000)
"In secondary-prevention trials to treat unstable angina, which were performed in USA and Canada, the number of non-fatal myocardial infarctions was reduced by about 50 per cent."6.38Anti-thrombotic drugs in the treatment of coronary heart disease: the present situation with aspirin. ( Born, GV, 1990)
"The mainstay of treatment for unstable coronary artery disease (UCAD) currently consists of antithrombotic therapy with aspirin plus unfractionated heparin (UFH), together with anti-ischemic treatment with beta blockers and nitrates."6.19Long-term management--the way forward? ( Wallentin, L, 2000)
" On the basis of present information it is evident that, in addition to heparin, all patients suffering from suspected acute myocardial infarction should receive immediate low dose aspirin which should be continued for one to six months."6.16Restoration of flow in acute coronary obstructive syndromes: consequences of different management strategies. ( McGregor, M; Silberberg, JS, 1989)
" The use of aspirin in unstable angina in the Canadian Aspirin trial was key to establishing the benefit of aspirin in acute coronary syndrome."5.22The Evolution of Antiplatelet Therapy After Percutaneous Coronary Interventions: A 40-Year Journey. ( Bainey, KR; Marquis-Gravel, G; Mehta, SR; Robert-Halabi, M; Tanguay, JF, 2022)
"Among patients with unstable angina or myocardial infarction without ST-segment elevation, prasugrel did not significantly reduce the frequency of the primary end point, as compared with clopidogrel, and similar risks of bleeding were observed."5.16Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. ( Ardissino, D; Armstrong, PW; Aylward, PE; Bhatt, DL; Boden, WE; Brown, EB; Cinteză, M; Clemmensen, P; Corbalan, R; Cornel, JH; Dalby, AJ; Fox, KA; Gasparovic, V; Goodman, SG; Gottlieb, S; Goudev, AR; Gurbel, PA; Hamm, C; Hochman, JS; Huber, K; Leiva-Pons, JL; Lokhnygina, Y; Martinez, F; McGuire, DK; McLendon, RC; Merkely, B; Nicolau, JC; Ohman, EM; Oto, A; Parkhomenko, A; Pavlides, G; Prabhakaran, D; Roe, MT; Ruzyllo, W; Topacio, GO; Tseng, CD; White, HD; Winters, KJ, 2012)
"Patients with medically managed unstable angina or non-ST-segment elevation myocardial infarction were enrolled in the TRILOGY ACS trial (2008 to 2011) comparing clopidogrel vs prasugrel."5.16Platelet function during extended prasugrel and clopidogrel therapy for patients with ACS treated without revascularization: the TRILOGY ACS platelet function substudy. ( Armstrong, PW; Brown, E; Chan, MY; Cornel, JH; Erlinge, D; Fox, KA; Goodman, SG; Gurbel, PA; Huber, K; Jakubowski, JA; Neely, B; Neely, M; Ohman, EM; Prabhakaran, D; Roe, MT; Tantry, US; White, HD; Zhou, C, 2012)
"The trial was terminated prematurely after recruitment of 7392 patients because of an increase in major bleeding events with apixaban in the absence of a counterbalancing reduction in recurrent ischemic events."5.15Apixaban with antiplatelet therapy after acute coronary syndrome. ( Alexander, JH; Atar, D; Bhatt, DL; Cools, F; Cornel, JH; Darius, H; De Caterina, R; Diaz, R; Flather, M; Geraldes, M; Goodman, S; Harrington, RA; He, Y; Huber, K; Husted, SE; James, S; Jansky, P; Keltai, M; Kilaru, R; Lawrence, J; Leiva-Pons, JL; Liaw, D; Lopes, RD; Lopez-Sendon, J; Mohan, P; Ogawa, H; Pais, P; Parkhomenko, A; Ruda, M; Ruzyllo, W; Verheugt, FW; Vinereanu, D; Wallentin, L; White, H, 2011)
"Acetylsalicylic acid (aspirin) is widely used in the secondary prevention of coronary artery disease."5.14Dose-related effect of aspirin on laboratory-defined platelet aggregation and clinical outcome after coronary stenting. ( Jannati, M; Khalili, A; Kojuri, J; Mahboodi, A; Mahmoody, Y; Zangbar Sabegh, B, 2010)
"Prasugrel is superior to clopidogrel in preventing ischemic events in patients with an acute coronary syndrome who are undergoing percutaneous coronary intervention, but it is associated with an increased risk of major bleeding."5.13Early and late benefits of prasugrel in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a TRITON-TIMI 38 (TRial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet InhibitioN with Prasugrel-Thrombolys ( Antman, EM; Braunwald, E; Chandna, H; Hasin, Y; Macias, W; McCabe, CH; Murphy, SA; Voitk, J; Widimsky, P; Wiviott, SD, 2008)
" Orbofiban, despite no significant excess risk of ICH, was not effective in preventing ischemic stroke or TIA."5.12Risk factors for stroke after acute coronary syndromes in the Orbofiban in Patients with Unstable Coronary Syndromes--Thrombolysis In Myocardial Infarction (OPUS-TIMI) 16 study. ( Cannon, CP; Feske, SK; Murphy, S; Schwamm, LH; Smith, EE, 2006)
"Patients with high-risk non-ST-segment elevation acute coronary syndromes (NSTE ACS) benefit from the early administration of aspirin, a small molecule glycoprotein IIb/IIIa inhibitor such as eptifibatide, and heparin."5.12Randomized evaluation of the efficacy of enoxaparin versus unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes receiving the glycoprotein IIb/IIIa inhibitor eptifibatide. Long-term results of the Integrilin ( Armstrong, PW; Fitchett, DH; Goodman, SG; Langer, A; Mendelsohn, A; Tan, M, 2006)
"Aspirin can inhibit inflammatory reactions and platelet aggregation, but little is known about the effects of the combination of aspirin plus clopidogrel, a new antiplatelet agent, on inflammation."5.12Effect of aspirin plus clopidogrel on inflammatory markers in patients with non-ST-segment elevation acute coronary syndrome. ( Chen, YG; Ji, QS; Li, RJ; Lü, RJ; Sun, Y; Xu, F; Zhang, Y, 2006)
"Thrombocytopenia, though uncommon, was associated with orbofiban use and an increased risk of bleeding, but also death and MI."5.12Drug-induced thrombocytopenia and thrombosis: evidence from patients receiving an oral glycoprotein IIb/IIIa inhibitor in the Orbofiban in Patients with Unstable coronary Syndromes- (OPUS-TIMI 16) trial. ( Aster, RH; Brassard, J; Braunwald, E; Cannon, CP; Charlesworth, A; Cooper, R; McCabe, CH; Scirica, BM; Skene, AM, 2006)
"Aspirin resistance may increase up to more then threefold the risk of major cardiovascular events (MACE) in patients with stable coronary artery disease."5.12The role of aspirin resistance on outcome in patients with acute coronary syndrome and the effect of clopidogrel therapy in the prevention of major cardiovascular events. ( Mercanoglu, F; Meric, M; Nisanci, Y; Oflaz, H; Oncul, A; Ozcan, M; Pamukcu, B; Umman, B, 2006)
" The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial demonstrated the effectiveness of clopidogrel plus acetylsalicylic acid (ASA) compared with ASA alone in reducing cardiovascular events in patients with acute coronary syndromes and, in addition, patients undergoing percutaneous coronary intervention in the Percutaneous Coronary Intervention in CURE (PCI-CURE) trial."5.12Cost-effectiveness of clopidogrel in acute coronary syndromes in Canada: a long-term analysis based on the CURE trial. ( Kolm, P; Mehta, SR; O'Brien, JA; Veledar, E; Weintraub, WS; Yuan, Y, 2007)
"We evaluated whether the use of glycoprotein IIb/IIIa receptor inhibitors, in addition to heparin and aspirin, imparts an incremental benefit in a subgroup of patients with acute coronary syndromes (ACS) who had congestive heart failure (CHF) symptoms at presentation."5.11Evaluating the benefits of glycoprotein IIb/IIIa inhibitors in heart failure at baseline in acute coronary syndromes. ( Harrington, RA; Hochman, JS; Houghtaling, PL; Jaber, WA; Marso, SP; Menon, V; Prior, DL; Simoons, ML; Srichai, MB, 2004)
" Platelet-leukocyte conjugate formation (induced by thrombin receptor activating peptide (TRAP)) and platelet aggregation (induced by ADP and arachidonic acid) were assessed in 30 patients with unstable angina or non-ST elevation myocardial infarction."5.11Prospective evaluation of the relationship between platelet-leukocyte conjugate formation and recurrent myocardial ischemia in patients with acute coronary syndromes. ( Bolton, ED; Braunstein, JB; Chiles, KA; Faraday, N; Gerstenblith, G; Heldman, AW; Schulman, SP, 2004)
"In the Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) trial, 12 562 patients were randomized to clopidogrel or placebo in addition to aspirin, and the primary outcome was cardiovascular (CV) death, myocardial infarction (MI), or stroke."5.11Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) Trial. ( Fox, KA; Gersh, BJ; Lakkis, N; Mehta, SR; Peters, R; Yusuf, S; Zhao, F, 2004)
"We evaluated stroke incidence, subtypes, and outcomes, in addition to demographics and clinical risk characteristics associated with stroke among patients enrolled in the Sibrafiban versus Aspirin to Yield Maximum Protection from Ischemic Heart Events Post-acute Coronary Syndromes (SYMPHONY) and 2nd SYMPHONY trials."5.11Incidence and characteristics of stroke during 90-day follow-up in patients stabilized after an acute coronary syndrome. ( Bhapkar, MV; Califf, RM; Graffagnino, C; Kassem-Moussa, H; Mahaffey, KW; Newby, LK; Sila, CA; Simes, RJ; Tasissa, G; White, HD, 2004)
" The purpose of the study was to evaluate the effects of tirofiban on clinical stabilization parameters in patients with unstable angina (UA) and non-Q-wave myocardial infarction (MI)."5.10Effects of glycoprotein IIb/IIIa inhibition on clinical stabilization parameters in patients with unstable angina and non-Q-wave myocardial infarction. ( Cakmak, M; Cam, N; Okmen, E; Tartan, Z, 2003)
"We studied the benefits and risks of adding clopidogrel to different doses of aspirin in the treatment of patients with acute coronary syndrome (ACS)."5.10Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study. ( Commerford, PJ; Diaz, R; Fox, KA; Kopecky, SL; Lewis, BS; Mehta, SR; Peters, RJ; Valentin, V; Yusuf, S; Zhao, F, 2003)
"Despite the use of heparin, aspirin, and other antiplatelet agents, acute coronary syndrome patients without ST-segment elevation remain at risk of cardiovascular thrombotic events."5.10Efficacy assessment of meloxicam, a preferential cyclooxygenase-2 inhibitor, in acute coronary syndromes without ST-segment elevation: the Nonsteroidal Anti-Inflammatory Drugs in Unstable Angina Treatment-2 (NUT-2) pilot study. ( Altman, R; Berman, SG; Del Rio, F; Gonzalez, C; Lopez, R; Luciardi, HL; Muntaner, J, 2002)
"Aspirin therapy confers conclusive net benefits in the acute phase of evolving myocardial infarction, but no clear evidence of benefit from the long-term use of aspirin after acute myocardial infarction (AMI) has been shown in any single study."5.09Effects of aspirin and trapidil on cardiovascular events after acute myocardial infarction. Japanese Antiplatelets Myocardial Infarction Study (JAMIS) Investigators. ( Hattori, R; Ishikawa, K; Masuda, Y; Miyazaki, S; Motomiya, T; Ogawa, H; Saito, M; Tamura, Y; Tanaka, H; Yamaguchi, T; Yasue, H, 1999)
"Forty-three patients presenting with unstable angina or myocardial infarction were randomised double blind to warfarin [target international normalised ratio (INR), 2."5.09Coronary artery flow ten weeks after myocardial infarction or unstable angina: effects of combined warfarin and aspirin therapy. ( Stewart, RA; Williams, MJ, 1999)
"Despite use of heparin and aspirin, 5-10% of patients with unstable angina develop myocardial infarction (MI) or refractory angina in the hospital."5.09Design, baseline characteristics, and preliminary clinical results of the Organization to Assess Strategies for Ischemic Syndromes-2 (OASIS-2) trial. ( Yusuf, S, 1999)
"The long-term risk of myocardial infarction (MI) or death remains high in patients with unstable angina, despite the use of aspirin."5.09Effects of long-term, moderate-intensity oral anticoagulation in addition to aspirin in unstable angina. The Organization to Assess Strategies for Ischemic Syndromes (OASIS) Investigators. ( , 2001)
"The rate of death, myocardial infarction, and urgent revascularization at days 8 and 43 after randomization was compared among patients who received aspirin within the week before randomization with those who did not receive aspirin in the TIMI 11B trial."5.09Prior aspirin users with acute non-ST-elevation coronary syndromes are at increased risk of cardiac events and benefit from enoxaparin. ( Antman, EM; Bozovich, GE; Gurfinkel, EP; Marcos, E; Mautner, B; McCabe, CH; Santopinto, J; Torres, V, 2001)
" At 5 hospitals, 39 patients with unstable angina or non-Q wave myocardial infarction, who were receiving aspirin and heparin, were administered intravenous AR-C69931MX with stepped dose increments over 3 h to a plateau of either 2 microg/kg/min for 21 h (Part 1; n = 12) or up to 69 h (Part 2; n = 13) or 4 microg/kg/min for up to 69 h (Part 3: n = 14)."5.09Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes. ( Oldroyd, KG; Storey, RF; Wilcox, RG, 2001)
"In patients with unstable angina and myocardial infarction without ST-segment elevation who were treated with the glycoprotein IIb/IIIa inhibitor tirofiban, the use of an early invasive strategy significantly reduced the incidence of major cardiac events."5.09Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban. ( Braunwald, E; Cannon, CP; DeLucca, PT; Demopoulos, LA; DiBattiste, PM; Frey, MJ; Gibson, CM; Lakkis, N; Neumann, FJ; Robertson, DH; Vicari, R; Weintraub, WS, 2001)
"The authors examined the bleeding complications in 75 patients who received acenocoumarol and acetylsalicylic acid combined therapy."5.08[Adverse effects of combined use of acenocoumarol and acetylsalicylic acid after myocardial infarct and unstable angina]. ( Farkas, A; Sámóczi, M; Sipos, E; Tarján, J, 1995)
"1506 patients with unstable CAD (unstable angina or non-Q-wave myocardial infarction) took part in a double-blind trial and were randomly assigned subcutaneous dalteparin (Fragmin; 120 IU per kg bodyweight [maximum 10 000 IU] twice daily for 6 days then 7500 IU once daily for the next 35-45 days) or placebo injections."5.08Low-molecular-weight heparin during instability in coronary artery disease, Fragmin during Instability in Coronary Artery Disease (FRISC) study group. ( , 1996)
"Our results add to previous evidence suggesting that the low-molecular-weight heparin dalteparin administered by twice-daily subcutaneous injection may be an alternative to unfractionated heparin in the acute treatment of unstable angina or non-Q-wave myocardial infarction."5.08Comparison of low-molecular-weight heparin with unfractionated heparin acutely and with placebo for 6 weeks in the management of unstable coronary artery disease. Fragmin in unstable coronary artery disease study (FRIC) ( Buchwald, A; Hillis, SE; Klein, W; Ludwig, K; Monrad, S; Olaisson, E; Sanz, G; Turpie, AG; Undeland, S; van der Meer, J, 1997)
"Antithrombotic therapy with enoxaparin plus aspirin was more effective than unfractionated heparin plus aspirin in reducing the incidence of ischemic events in patients with unstable angina or non-Q-wave myocardial infarction in the early phase."5.08A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events Study Group. ( Bigonzi, F; Califf, RM; Cohen, M; Demers, C; Fox, KA; Fromell, GJ; Goodman, S; Gurfinkel, EP; Langer, A; Premmereur, J; Turpie, AG, 1997)
" We evaluated tirofiban, a specific inhibitor of the platelet glycoprotein IIb/IIIa receptor, in the treatment of unstable angina and non-Q-wave myocardial infarction."5.08Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction. ( , 1998)
"In a multicenter trial of antithrombotic therapy in unstable angina or non-Q wave myocardial infarction, 358 patients admitted within 48 h of chest pain were randomized to antithrombotic therapy with either 1) aspirin alone, or 2) aspirin plus heparin followed by aspirin plus warfarin, and were prospectively followed up for 12 weeks."5.07Prospective comparison of unstable angina versus non-Q wave myocardial infarction during antithrombotic therapy. Antithrombotic Therapy in Acute Coronary Syndromes Research Group. ( Adams, PC; Chamberlain, D; Chesebro, JH; Cohen, M; Fox, KA; Fuster, V; McBride, R; Parry, G; Wieczorek, I; Xiong, J, 1993)
"The aim of this trial was to compare the efficacy of combination antithrombotic therapy with a prostacyclin-sparing aspirin plus anticoagulation versus conventional aspirin plus anticoagulation, when added to antianginal therapy, in patients with unstable angina or non-Q wave myocardial infarction already being treated with aspirin."5.07Prospective evaluation of a prostacyclin-sparing aspirin formulation and heparin/warfarin in aspirin users with unstable angina or non-Q wave myocardial infarction at rest. The Antithrombotic Therapy in Acute Coronary Syndromes Research Group. ( Adams, PC; Chamberlain, D; Cohen, M; Fox, KA; Fuster, V; Kronmal, R; Parry, G; Wieczorek, I; Xiong, J, 1994)
"This study compared the effects of heparin and aspirin versus aspirin alone on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina."5.07Comparison of the effect of heparin and aspirin versus aspirin alone on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina. ( Cunningham, D; Fox, K; Hendry, G; Holdright, D; Hubbard, W; Patel, D; Sutton, G; Thomas, R, 1994)
"This study documents that heparin prevents myocardial infarction better than aspirin during the acute phase of unstable angina."5.07Aspirin versus heparin to prevent myocardial infarction during the acute phase of unstable angina. ( de Guise, P; Juneau, M; McCans, J; Qiu, S; Théroux, P; Waters, D, 1993)
"The purpose of this study was to compare combination antithrombotic therapy with aspirin plus anticoagulation versus aspirin alone, when added to conventional antianginal therapy in patients with unstable rest angina or non-Q-wave myocardial infarction who were nonprior aspirin users."5.07Combination antithrombotic therapy in unstable rest angina and non-Q-wave infarction in nonprior aspirin users. Primary end points analysis from the ATACS trial. Antithrombotic Therapy in Acute Coronary Syndromes Research Group. ( Adams, PC; Chamberlain, D; Chesebro, JH; Cohen, M; Fox, KA; Keller, C; Parry, G; Strain, J; Wieczorek, I; Xiong, J, 1994)
"In this study, 796 men with unstable coronary artery disease (that is, unstable angina or non-Q wave myocardial infarction) were randomized to double-blind placebo-controlled treatment with aspirin (75 mg/day)."5.07Aspirin (75 mg/day) after an episode of unstable coronary artery disease: long-term effects on the risk for myocardial infarction, occurrence of severe angina and the need for revascularization. Research Group on Instability in Coronary Artery Disease in ( Wallentin, LC, 1991)
"We tested the usefulness of aspirin (325 mg twice daily), heparin (1000 units per hour by intravenous infusion), and a combination of the two in the early management of acute unstable angina pectoris in a double-blind, randomized, placebo-controlled trial involving 479 patients."5.06Aspirin, heparin, or both to treat acute unstable angina. ( deGuise, P; Joly, P; Juneau, M; Latour, JG; Lévy, G; McCans, J; Ouimet, H; Pelletier, E; Stasiak, J; Théroux, P, 1988)
"A randomized, double-blind clinical trial in 1266 men with unstable angina showed that 324 mg of aspirin daily for 12 weeks reduced the incidence of myocardial infarction by 51% (p = ."5.05Unstable angina: status of aspirin and other forms of therapy. ( Lewis, HD, 1985)
"In aspirin-treated patients with acute coronary syndromes without ST-segment elevation unfractionated heparin (UFH) or low molecular weight heparin (LMWH) treatment < 7 days significantly reduce the risk of acute myocardial infarction (AMI), and LMWH furthermore reduces revascularisation."4.86[Unfractionated heparin and low molecular weight heparin for acute coronary syndromes--assessment of a Cochrane review]. ( Husted, SE; Nielsen, HK, 2010)
" Irrespective of International normalized ratio (INR), A+W did not significantly affect the risk of major adverse events (MAE: all cause death, non-fatal myocardial infarction, and non-fatal thrombo-embolic stroke) when compared with aspirin alone [OR 0."4.83Aspirin plus warfarin compared to aspirin alone after acute coronary syndromes: an updated and comprehensive meta-analysis of 25,307 patients. ( Andreotti, F; Biondi-Zoccai, GG; Crea, F; Testa, L, 2006)
" The CURE study evaluated the efficacy and safety of clopidogrel on top of acetylsalicylic acid (ASA) versus standard therapy (including ASA) in over 12,000 patients with unstable angina or non-ST-segment elevation myocardial infarction (MI)."4.82Recent clinical trial results with antiplatelet therapy: implications in stroke prevention. ( Teal, PA, 2004)
" In patients with NSTEMI/UA, beta-blockers, nitrates and calcium antagonists will improve chest pain, and invasive management of ACS is indicated in < 48 h, if risk factors are present."4.82[Acute chest pain]. ( Perings, C; Trappe, HJ, 2005)
" Beta-blockers, nitrates, and calcium-channel blockers are useful for antiischemic therapy in patients with acute coronary syndromes."4.81[Acute coronary syndromes: an update. I. Pathogenesis and drug therapy]. ( Auer, J; Berent, R; Eber, B; Maurer, E; Mayr, H; Weber, T, 2001)
" coronary angioplasty (PTCA) with or without stent implantation), and in unstable angina/non-ST-segment elevation myocardial infarction, the risk of acute vessel occlusion by thrombosis is high in spite of treatment with aspirin and heparin."4.81Platelet glycoprotein IIb/IIIa blockers for percutaneous coronary revascularization, and unstable angina and non-ST-segment elevation myocardial infarction. ( Bosch, X; Marrugat, J, 2001)
" In the CAPRIE (Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events) Trial, clopidogrel (clopidogrel bisulphate) was superior to acetylsalicylic acid (ASA) in reducing the combined risk of ischaemic stroke (IS), myocardial infarction (MI) or vascular death in patients with symptomatic atherosclerosis."4.81From CURE to MATCH: ADP receptor antagonists as the treatment of choice for high-risk atherothrombotic patients. ( Hacke, W, 2002)
" On the contrary, the initial treatment with clopidogrel in addition to aspirin and anticoagulation led to a 20% relative risk reduction for an endpoint of death, myocardial infarction and stroke in the CURE trial."4.81[Modern therapy in acute coronary syndrome]. ( Blankenberg, S; Espinola-Klein, C; Meyer, J; Rupprecht, HJ, 2002)
"Antithrombotic and antiplatelet agents, particularly unfractionated heparin and aspirin, are longstanding therapeutic mainstays for acute coronary syndromes such as unstable angina and non-Q-wave myocardial infarction (MI)."4.80Anticoagulants in acute coronary syndromes. ( Turpie, AG, 1999)
"Aspirin, a potent platelet inhibitor, is widely used in patients with cardiovascular diseases."4.80[Aspirin and prevention of cardiovascular risk]. ( Gabriel Steg, P; Karila-Cohen, D, 2000)
"In the medical literature reports are accumulating a number of case reports suggesting the potential efficacy and safety of the combination of low-dose aspirin and warfarin to improve the efficacy of antithrombotic therapy in several clinical conditions, ranging from unstable angina to myocardial infarction."4.79[The new frontier of antithrombotic therapy: ASA + warfarin, the ideal solution?]. ( Casazza, F; Cimminiello, C; Soncini, M, 1995)
" The recent clinical reports suggest that there is a narrower window of safety with recombinant hirudin than initially thought particularly when it is used in conjunction with thrombolytic agents and aspirin in acute myocardial infarction."4.79Advances in antithrombotic therapy: novel agents. ( Hirsh, J; Turpie, AG; Weitz, JI, 1995)
"Both experimental and clinical studies suggest that the prehospital administration of aspirin may be beneficial in patients with unstable angina and acute myocardial infarction."4.79Prehospital administration of aspirin in patients with unstable angina and acute myocardial infarction. ( Eisenberg, MJ; Topal, EJ, 1996)
"To estimate the risk of myocardial infarction (MI) and death in patients with unstable angina who are treated with aspirin plus heparin compared with patients treated with aspirin alone."4.79Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina. A meta-analysis. ( Grady, D; Oler, A; Oler, J; Whooley, MA, 1996)
"The formation of the proischemic and prothrombotic thromboxane A2 (TXA2) and of its functional antagonist prostacyclin is increased in patients with unstable angina and myocardial infarction."4.78Pathophysiological role of thromboxane A2 and pharmacological approaches to its inhibition. ( Hornberger, W; Patscheke, H; Zehender, H, 1990)
"The use of aspirin and thrombolytic agents in the management of acute myocardial infarction is now accepted as standard clinical practice, but not all patients with heart attack are suitable for such therapy."4.78Aspirin and thrombolytic therapy in the management of acute myocardial infarction. ( Hockings, B, 1990)
" These studies, in conjunction with recent histopathologic studies demonstrating plaque defects and overlying thrombosis in patients with unstable ischemia and sudden death, suggest a common mechanism for unstable angina and myocardial infarction and strongly support the rationale for antithrombotic therapy with heparin and with aspirin in the management of patients with unstable angina."4.77Thrombosis in unstable angina: angiographic aspects. ( Cowley, MJ; DiSciascio, G; Rehr, RB, 1987)
"The present study concluded that long-term dual antiplatelet therapy including clopidogrel and aspirin could decrease the risks of all-cause death, myocardial infarction."4.02Treatment Outcomes of Clopidogrel in Patients With ACS and Diabetes Undergoing PCI-Analysis of Beijing Municipal Medical Insurance Database. ( Guo, L; Man, F; Pan, Q; Wang, W; Wang, X; Zhang, J; Zhang, L, 2021)
"Antithrombotic treatment of unstable angina is a highly controversial subject."3.79[Antithrombotic agents in unstable angina. Review of clinical trials]. ( Habis, M; Morice, MC, 1998)
"One-year treatment with clopidogrel in addition to aspirin is a cost-effective treatment option for secondary prevention in patients with acute coronary syndrome without ST-segment elevation in Greece."3.78Economic evaluation of clopidogrel in acute coronary syndrome patients without ST-segment elevation in Greece: a cost-utility analysis. ( Fragoulakis, V; Kourlaba, G; Maniadakis, N, 2012)
"Pre-hospitalization medication such as aspirin and nitrates has been shown to affect the mode of presentation in acute coronary syndrome (ACS)."3.77Differences in the mode of presentation for acute coronary syndrome by pre-hospitalization medication, in relation to coronary risk factors, East-Osaka acute coronary syndrome (EACS) registry. ( Hoshida, S; Iwasaka, J; Iwasaka, T; Kijima, Y; Lim, YJ; Yuasa, F, 2011)
"In this study, we aimed to assess the factors associated with laboratory-defined aspirin resistance and the relationship of this laboratory-defined aspirin resistance with thrombolysis in myocardial infarction risk score, markers of cardiac necrosis, and inflammatory and thrombotic risk factors in patients with unstable angina or non-ST elevation myocardial infarction."3.75The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes. ( Acikel, S; Aydinalp, A; Bal, U; Kaynar, G; Muderrisoglu, H; Ozin, B; Yildirir, A, 2009)
" Poisson regression models were used to assess whether CAM use was independently associated with lower rates of aspirin, beta-blocker, and statin use in 596 patients with established coronary artery disease (CAD)."3.74Self-reported use of complementary and alternative medicine in patients with previous acute coronary syndrome. ( Banerjee, S; Buchanan, DM; Decker, C; Huddleston, J; Jones, A; Kosiborod, M; Spertus, JA; Stoner, C, 2007)
"Recent studies have suggested that low-dose aspirin has preserved benefit with less bleeding compared with standard-dose aspirin when given with or without clopidogrel in patients with high-risk non-ST-segment elevation acute coronary syndromes (NSTE ACSs)."3.74Patterns of aspirin dosing in non-ST-elevation acute coronary syndromes in the CRUSADE Quality Improvement Initiative. ( Cannon, CP; Gibler, WB; Milford-Beland, S; Ohman, EM; Peterson, ED; Pollack, CV; Roe, MT; Tickoo, S, 2007)
"Platelet function analyses, which included measures of platelet aggregation and activation, were performed in 173 T2DM patients with coronary artery disease on chronic treatment with aspirin and clopidogrel."3.74Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease. ( Alfonso, F; Angiolillo, DJ; Bañuelos, C; Bass, TA; Bernardo, E; Costa, MA; Escaned, J; Fernandez-Ortiz, A; Guzman, LA; Hernández-Antolin, R; Jimenez-Quevedo, P; Macaya, C; Moreno, R; Palazuelos, J; Sabaté, M, 2007)
"To compare the efficacy of intravenous versus oral aspirin use in patients with acute coronary syndrome (ACS)."3.74[Efficacy of intravenous aspirin use in patients with acute coronary syndrome]. ( Shen, LH; Yang, M; Zhao, Y, 2007)
"Aspirin has been used for secondary prevention of myocardial infarction (MI) in individuals with coronary disease."3.74Failure of aspirin to prevent myocardial infarction and adverse outcome during follow-up - a large series of all-comers. ( Eskola, M; Karhunen, PJ; Mikkelsson, J; Niemela, K; Nikus, K, 2008)
" Hospital charts review revealed key information for clinical variables, smoking, obesity and use of aspirin at admission."3.74Positive predictive value of ICD-9 codes 410 and 411 in the identification of cases of acute coronary syndromes in the Saskatchewan Hospital automated database. ( Aguado, J; Castellsague, J; Perez-Gutthann, S; Stang, MR; Tomas, L; Varas-Lorenzo, C, 2008)
" The cost-effectiveness of longer combination therapy depends critically on the balance of thrombotic event rates, durable efficacy, and the increased bleeding rate in patients taking clopidogrel."3.73A cost-effectiveness analysis of combination antiplatelet therapy for high-risk acute coronary syndromes: clopidogrel plus aspirin versus aspirin alone. ( Heidenreich, PA; Schleinitz, MD, 2005)
"Utilizing data from the Global Registry of Acute Coronary Events, we studied 15 693 patients admitted with non-ST-segment elevation myocardial infarction (MI) or unstable angina, dividing them according to discharge medications: aspirin alone (group I); aspirin + clopidogrel (group II); aspirin + statin (group III); aspirin + clopidogrel + statin (group IV)."3.73Impact of combined pharmacologic treatment with clopidogrel and a statin on outcomes of patients with non-ST-segment elevation acute coronary syndromes: perspectives from a large multinational registry. ( Agnelli, G; Dabbous, OH; Dibenedetto, D; Eagle, KA; Gore, JM; Kline-Rogers, EM; Lim, MJ; Mehta, RH; Spencer, FA, 2005)
"Our study demonstrates an increased risk of major bleeding in unselected patients receiving combination therapy with ASA and clopidogrel after UAP or NSTEMI."3.73[Bleeding complications after treatment with clopidogrel and acetylsalicylic acid after acute coronary syndrome]. ( Kjaer, J; Larsen, CH; Mickley, H; Møller, JE; Poulsen, TS, 2006)
"We report a case of a 76-year-old-man who developed spontaneous hemarthrosis of his right knee following clopidogrel-aspirin treatment."3.72Spontaneous hemarthrosis of the knee associated with clopidogrel and aspirin treatment. ( Behrens, P; Bernotat, J; Böhm, S; Gille, J; Löhr, JF, 2003)
"We performed a retrospective analysis of the Mayo Clinic PCI database and identified 66 consecutive patients who were discharged from hospital after PCI between January 2000 and August 2002 (inclusive) receiving a combination of dual antiplatelet therapy (aspirin and clopidogrel) and systemic anticoagulation (warfarin) to determine the incidence of bleeding and other clinical events during the treatment period."3.72Safety and efficacy of aspirin, clopidogrel, and warfarin after coronary stent placement in patients with an indication for anticoagulation. ( Berger, PB; Burger, K; Fasseas, P; Holmes, DR; Melby, S; Orford, JL; Steinhubl, SR, 2004)
"The possible additive antiplatelet effects of aspirin and clopidogrel have been explored in the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) and Management of Atherothrombosis with Clopidogrel in High Risk Patients (MATCH) studies."3.72Long-term combination therapy with aspirin and clopidogrel. ( Cheung, BM; Cheung, G; Kumana, CR; Lauder, IJ, 2004)
"Aspirin is widely used as an antiplatelet drug in patients with coronary heart disease."3.72Unstable angina, stroke, myocardial infarction and death in aspirin non-responders. A prospective, randomized trial. The ASCET (ASpirin non-responsiveness and Clopidogrel Endpoint Trial) design. ( Abdelnoor, M; Arnesen, H; Pettersen, AA; Seljeflot, I, 2004)
" The coronary reperfusion was achieved in 59% patients with acute myocardial infarction (MI) treated with thrombolysis, but in 27% patients with MI treated only heparin and aspirin."3.71[Prospective analysis of conservative treatment of acute coronary syndrome]. ( Batyraliev, TA; Daniiarov, BS; Niiazova-Karben, ZA; Pershukov, IV; Pia, IuV; Preobrazhenskiĭ, DV; Sidorenko, BA, 2002)
"Aspirin's role in the management of suspected myocardial infarction has been well established."3.71A study of the use of aspirin by general practitioners in suspected myocardial infarction. ( O'Shea, EB, 2001)
"ASPIRIN AND HEPARIN: In several studies aspirin has been found to be very effective in unstable angina pectoris reducing fatal and non-fatal myocardial infarction by 50-70%."3.71[Optimal platelet inhibition therapy in unstable angina pectoris and after coronary interventions]. ( Huber, K; Niessner, A; Niessner, H, 2001)
" The CURE trial shows that clopidogrel in addition to aspirin achieves this double goal, with a 20% relative risk reduction in the primary composite endpoint of cardiovascular death, myocardial infarction or stroke in the first 30 days."3.71[Clopidogrel in acute coronary syndromes with non-ST elevation. Clinical implications of the CURE trial]. ( Valentín, V, 2001)
"The current standard of care for patients with non-ST-segment elevation acute coronary syndromes (ACS) includes antithrombotic therapy with aspirin and heparin."3.71Influence of patient characteristics and renal function on factor Xa inhibition pharmacokinetics and pharmacodynamics after enoxaparin administration in non-ST-segment elevation acute coronary syndromes. ( Antman, EM; Ball, SP; Becker, RC; Gibson, M; Murphy, SA; Rush, JE; Sanderink, G; Spencer, FA, 2002)
"Aspirin is an established therapy for the management of acute myocardial infarction (AMI) and unstable angina."3.70New antiplatelet agents. ( Ellis, CJ; French, JK; White, HD, 1998)
"SYMPHONY (Sibrafiban versus aspirin to Yield Maximum Protection from ischemic Heart events post-acute cOroNary syndromes) was a randomized, double-blind, aspirin-controlled trial with 2 concentration regimens of sibrafiban, an oral peptidomimetic GP IIb/IIIa antagonist, for long-term treatment instead of aspirin in patients after an ACS."3.70Long-term oral platelet glycoprotein IIb/IIIa receptor antagonism with sibrafiban after acute coronary syndromes: study design of the sibrafiban versus aspirin to yield maximum protection from ischemic heart events post-acute coronary syndromes (SYMPHONY) ( Newby, LK, 1999)
"(1) Enoxaparin and dalteparin are the only low-molecular-weight heparins so far approved for the treatment of unstable angina and non Q-wave myocardial infarction."3.70Enoxaparin and dalteparin in unstable angina: new indication. Enoxaparin: a reference treatment. Dalteparin: no better than unfractionated heparin. ( , 1999)
" We analyzed the early (30 days) and late outcome of a cohort of 459 consecutive patients who underwent stent placement with ticlopidine and aspirin as antithrombotic regimen according to the presence (group 1, n = 151) or absence (group 2, n = 308) of unstable angina at rest (Braunwald classes II and III)."3.70Long-term outcome in patients treated by intracoronary stenting with ticlopidine and aspirin, and deleterious prognostic role of unstable angina pectoris. ( Alla, F; Angioi, M; Cherrier, F; Danchin, N; Gangloff, C; Grentzinger, A; Houplon, P; Juillière, Y; Preiss, JP; Rodriguez, RM; Sunthorn, H, 2000)
"(1) Aspirin reduces acute-phase mortality after myocardial infarction, and also reduces the risk of myocardial infarction and death in patients with unstable angina."3.70Antiplatelet drugs in cardiovascular prevention: coronary events: acute phase and secondary prevention. ( , 2000)
"The present study was designed to investigate whether the prior use of aspirin could influence the severity of the manifestation of acute coronary artery syndromes, given the well-documented observations that aspirin can prevent myocardial infarction, stroke, and death in cardiovascular disease."3.69Previous aspirin use may attenuate the severity of the manifestation of acute ischemic syndromes. ( Garcia-Dorado, D; Oliveras, J; Sambola, A; Santos, M; Soler Soler, J; Théroux, P; Tornos, P, 1995)
"We conducted a retrospective case-control study to compare the frequency of myocardial infarction (MI) or unstable angina (UA) precipitated by aspirin-induced upper gastrointestinal (GI) bleeding among patients with and without ischemic heart disease(IHD), and to determine whether the risk of MI or UA is related to the hemoglobin level on admission."3.69Low dose aspirin in patients with ischemic heart disease may precipitate secondary myocardial infarction. ( Amital, H; Bar Dayan, Y; Levy, Y; Shoenfeld, Y, 1996)
"We present a series of fifteen patients treated with low dose aspirin for secondary prevention of ischemic heart disease who had upper GI bleeding and were admitted to our hospital because of unstable angina or myocardial infarction."3.69Aspirin for prevention of myocardial infarction. A double-edged sword. ( Amital, H; Bar-Dayan, Y; Levy, Y; Shoenfeld, Y, 1997)
"Platelet functional parameters (platelet aggregation, blood circulating reversibly and irreversibly aggregated platelet complexes, thromboxane B2, 6-keto-PGF1 alpha) were examined in unstable angina treated with aspirin in a daily dose of 320 mg in relation to the outcome of the disease: Group 1, stabilization and Group 2, evolving myocardial infarction."3.68[Development of myocardial infarction in aspirin-treated unstable angina pectoris. Repeated studies of platelet aggregation and of the thromboxane-prostacyclin system]. ( Shalaev, SV, 1992)
"We randomly divided 100 unstable angina pectoris (UAP) patients into two groups: the trial group received Sulfotanshinone Sodium Injection (SSI) 60 mg combined with a loading dose of 300 mg aspirin and a maintenance dose of 100 mg of aspirin plus baseline therapy, and the control group received the same doses of aspirin and baseline therapy."2.74Sulfotanshinone Sodium Injection could decrease fibrinogen level and improve clinical outcomes in patients with unstable angina pectoris. ( Liu, Y; Liu, YF; Yan, FF; Zhao, YX, 2009)
"Myocardial infarction was more frequent in the early invasive strategy group (106 [18."2.73Long-term outcome after an early invasive versus selective invasive treatment strategy in patients with non-ST-elevation acute coronary syndrome and elevated cardiac troponin T (the ICTUS trial): a follow-up study. ( Cornel, JH; de Winter, RJ; Hirsch, A; Tijssen, JG; Verheugt, FW; Windhausen, F, 2007)
"0001), and major adverse cardiac events (8."2.73Safety of sirolimus-eluting stenting and its effect on restenosis in patients with unstable angina pectoris (a SIRIUS substudy). ( Holmes, DR; Kuntz, RE; Leon, MB; Mishkel, G; Moses, JW; Popma, JJ; Raizner, AE; Satler, LF; Teirstein, PS; Wang, P; Weisz, G; Wilensky, RL, 2007)
"We examined the prevalence and medical treatment of hypertension among 15,904 ACS patients randomized in the SYMPHONY and 2nd SYMPHONY trials."2.71Prevalence and management of hypertension in acute coronary syndrome patients varies by sex: observations from the Sibrafiban versus aspirin to Yield Maximum Protection from ischemic Heart events postacute cOroNary sYndromes (SYMPHONY) randomized clinical ( Armstrong, PW; Aylward, PE; Bhapkar, MV; Frazier, CG; Klein, WW; Kristinsson, A; McGuire, DK; Newby, LK; Sadowski, Z; Shah, SH; Weaver, WD, 2005)
"Both aspirin and beta-adrenergic blocking drugs have been shown to reduce the risk of death or acute myocardial infarction (AMI) in patients with unstable angina, but their effect during chronic use on the presentation of acute coronary syndromes is less well defined."2.69Effects of prior aspirin and anti-ischemic therapy on outcome of patients with unstable angina. TIMI 7 Investigators. Thrombin Inhibition in Myocardial Ischemia. ( Antman, EM; Becker, RC; Borzak, S; Braunwald, E; Cannon, CP; Douthat, L; Fuchs, J; Henry, T; Hochman, JS; Kraft, PL; McCabe, C; Palmeri, ST, 1998)
"Tirofiban was generally well tolerated and, as compared with heparin, reduced ischemic events during the 48-hour infusion period, during which revascularization procedures were not performed."2.69A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina. ( , 1998)
"Eptifibatide was not associated with an increase in intracranial hemorrhage, and no significant effect on nonhemorrhagic stroke was observed."2.69Stroke in patients with acute coronary syndromes: incidence and outcomes in the platelet glycoprotein IIb/IIIa in unstable angina. Receptor suppression using integrilin therapy (PURSUIT) trial. The PURSUIT Investigators. ( Alberts, MJ; Berdan, LG; Califf, RM; Deckers, J; Graffagnino, C; Granger, CB; Harrington, RA; Laskowitz, DT; Lincoff, AM; MacAulay, CM; Mahaffey, KW; Miller, JM; Simoons, ML; Sloan, MA; Topol, EJ, 1999)
"Abciximab produced a 58% reduction in thrombus formation (11,631 +/- 861 vs 4, 925 +/- 585 microm(2); p <0."2.69Antithrombotic effects of abciximab. ( Badimon, JJ; Badimon, L; Chesebro, JH; Coller, BS; Dangas, G; Fallon, JT; Fuster, V; Hayes, R; Marmur, JD; Sharma, SK, 2000)
"In dalteparin-treated patients, delta vWf was elevated (+48 +/- 8%) and did not differ from the unfractionated heparin group (NS)."2.69Effects of various anticoagulant treatments on von Willebrand factor release in unstable angina. ( Ankri, A; Choussat, R; Collet, JP; Drobinski, G; Lison, L; Montalescot, G; Perlemuter, K; Philippe, F; Thomas, D; Vicaut, E, 2000)
"Unstable angina is associated with enhanced lipid peroxidation and reduced antioxidant defenses."2.69Oxidant stress and aspirin-insensitive thromboxane biosynthesis in severe unstable angina. ( Bucciarelli, T; Ciabattoni, G; Cipollone, F; Cuccurullo, F; Davì, G; Di Gregorio, D; Pasquale, M; Patrignani, P; Patrono, C, 2000)
"When ticlopidine was given for 72 hours, TF levels were similar to normal laboratory values both in stable and unstable patients."2.69Effect of aspirin and ticlopidine on plasma tissue factor levels in stable and unstable angina pectoris. ( Ariëns, RA; Bernies, M; Bossi, IM; Brambilla, GM; Donatelli, F; Fajadet, J; Gregorini, L; Marco, I; Marco, J; Mari, D; Romano, SM; Somalvico, F, 2000)
"Nonfatal myocardial infarction was present in seven patients in group A, four in group B and none in group C (group B vs."2.68Low molecular weight heparin versus regular heparin or aspirin in the treatment of unstable angina and silent ischemia. ( Cerdá, MA; Daroca, AM; Duronto, EA; García, CN; Gurfinkel, EP; Manos, EJ; Mautner, B; Mejaíl, RI, 1995)
"Prognosis of unstable angina pectoris is related to admission EKG changes and prompt symptom control."2.68[Diltiazem versus intravenous nitroglycerin in the treatment of unstable angina pectoris. A randomized study]. ( Castro, P; Corbalán, R; Kunstmann, S; Vergara, I, 1995)
"Dipyridamole was applied in 550 interventions (455 interventions in men, 95 interventions in women, age = 59."2.68[Intracoronary dipyridamole reduces the incidence of acute coronary vessel occlusion in percutaneous transluminal coronary angioplasty--a prospective randomized study]. ( Heidland, UE; Heintzen, MP; Kelm, M; Klimek, WJ; Leschke, M; Michel, CJ; Schwartzkopff, B; Strauer, BE; Vester, EG, 1997)
"Ticlopidine was found to produce more marked effects on ADT-induced plasma platelet aggregation, in vivo reversible platelet aggregation, and reduced platelet levels of free cholesterol, as compared to aspirin."2.67[Ticlopidine and aspirin in the treatment of unstable angina: comparative evaluation of their effect of anti-aggregation and platelet membranes]. ( Mezhetskaia, IA; Shalaev, SV, 1993)
"Heparin is an effective, widely used treatment for unstable angina."2.67Reactivation of unstable angina after the discontinuation of heparin. ( Juneau, M; Lam, J; McCans, J; Théroux, P; Waters, D, 1992)
"We conclude that patients with unstable angina pectoris have a similar outcome after two years whether they receive medical therapy alone or coronary bypass surgery plus medical therapy."2.66Comparison of medical and surgical treatment for unstable angina pectoris. Results of a Veterans Administration Cooperative Study. ( Deupree, RH; Luchi, RJ; Scott, SM, 1987)
"Patients with unstable angina pectoris/non-ST-elevation myocardial infarction (NSTEMI) should be treated with dual antiplatelet therapy with the use of aspirin plus either clopidogrel, prasugrel, or ticagrelor depending on the clinical circumstances as discussed in this article."2.49Use of antiplatelet drugs in the treatment of acute coronary syndromes. ( Aronow, WS, 2013)
"Non-ST elevation acute coronary syndromes are responsible for approximately 1 million admissions to U."2.48Unstable angina and non-ST elevation myocardial infarction. ( Braunwald, E, 2012)
"As well as initiating thrombus formation at the site of a ruptured atherosclerotic plaque, platelets play a key role in vascular inflammation, through release of their own pro-inflammatory mediators and interactions with other relevant cell types (endothelial cells, leukocytes, and smooth muscle cells)."2.44Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease. ( Badimon, JJ; Bhatt, DL; Herbert, JM; Lüscher, TF; Steinhubl, SR, 2007)
"Elderly patients with unstable angina pectoris/non-ST-segment elevation myocardial infarction should be hospitalized."2.42Treatment of unstable angina pectoris/non-ST-segment elevation myocardial infarction in elderly patients. ( Aronow, WS, 2003)
"Aspirin, however, has become a lifelong therapy for many patients, based on clinical trials and medical experience."2.42Role of clopidogrel in unstable angina and non-ST-segment elevation myocardial infarction: from literature and guidelines to practice. ( Kerr, JL; Oppelt, TF; Rowen, RC, 2004)
"Patients presenting with unstable angina pectoris or non-Q-wave myocardial infarction (MI), if treated inadequately, are at a high risk of MI and subsequent mortality."2.41Current management of unstable angina: lessons from the TACTICS-TIMI 18 trial. ( Adgey, AA; Manoharan, G, 2002)
"The National Heart Attack Alert Program established a Working Group to review the utility of critical pathways on quality of care and outcomes for patients with ACS."2.41Critical pathways for management of patients with acute coronary syndromes: an assessment by the National Heart Attack Alert Program. ( Bahr, R; Boden, WE; Cannon, CP; Christenson, R; Eagle, K; Gibler, WB; Hand, MH; Lambrew, CT; Lee, TH; MacLeod, B; Ornato, JP; Selker, HP; Steele, P; Zalenski, RJ, 2002)
" Because of the need for frequent anticoagulation monitoring and dosage adjustment, the use of heparin is limited to short-term treatment during the acute in-hospital phase."2.40New therapies for unstable angina and non-Q-wave myocardial infarction: recent clinical trials. ( Cohen, M, 1998)
" Clinical trial evidence is now available to show that the LMWH enoxaparin, in a dosage of 1."2.40Treatment options in unstable angina: a clinical update. ( Antman, EM; Fox, KA, 1998)
" Women presenting with unstable angina or myocardial infarction should receive aspirin 325 mg as soon as the diagnosis is confirmed, and this dosage should be continued on a chronic basis."2.38Aspirin for the prevention of vascular death in women. ( Corn, CR; Hamilton, SF; McAnally, LE, 1992)
"Unstable angina is a clinical syndrome characterized by increased rate and severity of angina pectoris attacks and, sometimes but not always, accompanied by ECG changes similar to those seen in coronary insufficiency."2.38Unstable angina: pathophysiology and drug therapy. ( Bleifeld, W, 1990)
" There was disagreement concerning the dosage of heparin and the exact use of betablockers, aspirin, warfarin, ACE-inhibitors, magnesium and antiarrhythmics."2.38[Drug therapy of acute coronary syndrome. Summary of a hearing arranged by the Norwegian Cardiologic Society and the Institute of pharmacotherapy]. ( Amlie, JP; Aursnes, I; Osnes, JB; Platou, ES; Smiseth, OA, 1990)
"In secondary-prevention trials to treat unstable angina, which were performed in USA and Canada, the number of non-fatal myocardial infarctions was reduced by about 50 per cent."2.38Anti-thrombotic drugs in the treatment of coronary heart disease: the present situation with aspirin. ( Born, GV, 1990)
"Heparin therapy for unstable angina has appeared promising, but no properly conducted randomized trial has been accomplished."2.37Which role for antiplatelet and anticoagulant drugs in unstable angina pectoris? ( Lewis, HD, 1988)
"Age above 55 years was associated with recurrence of ACS in C2238/ANP-minor allele carriers (hazard ratio 1."1.43T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients. ( Abbolito, S; Battistoni, A; Bianchi, F; Burocchi, S; Cangianiello, S; Caprinozzi, M; Comito, F; Cotugno, M; De Giusti, M; Di Castro, S; Dito, E; Farcomeni, A; Greco, ES; Marchitti, S; Pagliaro, B; Pierelli, G; Rubattu, S; Sciarretta, S; Stanzione, R; Volpe, M, 2016)
"Aspirin fills were more common in younger veterans, Blacks, Hispanics, males, hypertensive veterans, mentally ill patients, those with no co-pay and those prescribed antiplatelets/anticoagulants in addition to aspirin postoperatively."1.42Use of Health Care System-Supplied Aspirin by Veterans With Postoperative Heart Attack or Unstable Angina. ( Copeland, LA; MacCarthy, DJ; McNeal, CJ; Mortensen, EM; Pugh, MJ; Rivera, CM, 2015)
"Smoking, alcohol abuse, and obesity were more common in patients with ST elevation myocardial infarction (STEMI) (P < 0."1.42Management of acute coronary syndromes in a developing country; time for a paradigm shift? an observational study. ( Bandara, R; De Silva, C; Galgomuwa, MP; Medagama, A, 2015)
"Hemorrhagic cholecystitis is a rare and potentially fatal complication of biliary tract disease."1.36Hemorrhagic cholecystitis after anticoagulation therapy. ( Chen, CL; Chen, YY; Hsu, YH; Huang, SC; Yi, CH, 2010)
"Aspirin resistance was observed in 38 patients (36."1.35Responsiveness to aspirin in patients with unstable angina pectoris by whole blood aggregometry. ( Dong, HM; Huang, L; Jian, Z; Li, JB; Wu, XJ; Yu, SY; Zhao, XH, 2009)
" Examined a different way, the mean percentage of days that the correct aspirin dosage (1 pill per day for all patients) was taken was significantly lower in the persistently depressed patients (76."1.33Persistent depressive symptoms lower aspirin adherence after acute coronary syndromes. ( Burg, MM; Chaplin, WF; Davidson, KW; Gerin, W; Haas, D; Kronish, IM; Rieckmann, N; Vorchheimer, D, 2006)
"Diabetes Mellitus is a chronic disease frequently associated to ischemic heart disease and both disease require continuing medical care, aggressive treatment of other risk factors, educational programs for self management of disease to prevent acute complication."1.32[Recommendations for cardiovascular rehabilitation in diabetes mellitus]. ( Biorci, ML; Camerini, A; Chieffo, C; Comaschi, M; Faglia, E; Fattirolli, F; Gattone, M; Giorda, C; Griffo, R; Mannucci, E, 2003)
"In patients with unstable angina pectoris or non-ST-elevation myocardial infarction treated with aspirin, heparin, and tirofiban, performance of an exercise or a pharmacologic stress test in selected patients within 48 to 72 hours after admission appears to be associated with a low risk of complications."1.32Safety of stress testing during the evolution of unstable angina pectoris or non-ST-elevation myocardial infarction. ( Cannon, CP; Dibattiste, PM; Gibson, CM; Karha, J; Murphy, SA, 2004)
"Unstable angina was defined as transient S-T segment changes without significant increases in CK and CK-MB."1.31Prior aspirin use in unstable angina patients with modified plasma inflammatory markers and endothelial nitric oxide synthase in neutrophils. ( de Andres, R; Farré, J; García-Méndez, A; Gómez, J; López-Farré, A; Mateos-Cáreres, PJ; Rico, L; Romero, J; Sánchez de Miguel, L, 2002)
"Aspirin has the potential to influence CRP release, either by its anti-inflammatory activity or by reducing myocardial necrosis."1.31The effect of aspirin on C-reactive protein as a marker of risk in unstable angina. ( Clarke, H; Cooper, J; Kennon, S; Mills, PG; Price, CP; Ranjadayalan, K; Timmis, AD, 2001)
" We present several illustrative cases in which platelet monitoring with the Rapid Platelet Function Assay (RPFA, Accumetrics) was used to guide dosing of a glycoprotein (GP) IIb/IIIa inhibitor for coronary and peripheral intervention among patients at increased bleeding risk."1.31Clinical application of procedural platelet monitoring during percutaneous coronary intervention among patients at increased bleeding risk. ( Chew, DP; Moliterno, DJ; Mukherjee, D; Raymond, RE; Robbins, M; Yadav, JS, 2001)
"Aspirin was prescribed to 82."1.31Quality of care among elderly patients hospitalized with unstable angina. ( Krumholz, HM; Lewis, JM; Petrillo, MK; Radford, MJ; Rathore, SS; Shahi, CN; Thakur, R; Wang, Y; Wu, WC, 2001)
" The investigations were performed with different amounts of 4 different inducers (ADP, arachidonic acid, epinephrine and collagen) taking dose-response curves."1.30[The rate of acetylsalicylic acid non-respondents among patients hospitalized for acute coronary disease, previously undergoing secondary salicylic acid prophylaxis]. ( Barczi, V; Blaskó, G; Dinnyés, J; Hamvas, J; Jáger, R; Kinczel, A; Pál, A; Poór, F; Salamon, A; Tarján, J, 1999)
" With the increase of aspirin dosage the degree of these two changes increased (P < 0."1.29[Effects of different lowdoses of aspirin on platelet activation and the number of platelets in the patients with coronary heart disease]. ( Ouyang, M; Sheng, C; Si, F, 1996)
"Questionnaires about therapy in unstable angina pectoris were sent to 63 Danish medical departments and were answered by 52 departments (82."1.28[Treatment of unstable angina pectoris. A questionnaire study]. ( Christiansen, IB; Juul, A; Nielsen, JD; Siemsen, M; Stoltenberg, M, 1990)

Research

Studies (498)

TimeframeStudies, this research(%)All Research%
pre-199044 (8.84)18.7374
1990's183 (36.75)18.2507
2000's227 (45.58)29.6817
2010's38 (7.63)24.3611
2020's6 (1.20)2.80

Authors

AuthorsStudies
Marquis-Gravel, G1
Robert-Halabi, M1
Bainey, KR1
Tanguay, JF1
Mehta, SR8
Martí, D1
Carballeira, D1
Morales, MJ1
Concepción, R1
Del Castillo, H1
Marschall, A1
Delgado-Calva, FA1
Dejuán-Bitriá, C1
Pérez-Guzmán, J1
López-Soberón, E1
Palazuelos, J2
Álvarez-Antón, S1
Cheng, D1
Zhao, S1
Hao, Y1
Corbett, SJ1
Ftouh, S1
Lewis, S1
Lovibond, K1
Clarkson, SA1
Heindl, B1
Cai, A1
Beasley, M1
Dillon, C1
Limdi, N1
Brown, TM1
Wang, W1
Wang, X1
Zhang, L2
Zhang, J1
Man, F1
Pan, Q1
Guo, L1
Bishop, W1
Girao, G1
Schäfer, A3
Bauersachs, J2
Ertaş, FS1
Tokgozoglu, L1
Aronow, WS2
Arntz, HR1
Boudriot, E1
Garlichs, C1
Hoffmann, S1
Ince, H1
Klingenheben, T1
Weil, J1
Zugck, C1
Helms, TM1
Silber, S1
Zaval's'ka, TV1
Cho, EH1
Ligh, C1
Hodulik, KL1
Hollenbeck, ST1
Agmadova, ZM1
Kallaeva, AN1
Rubattu, S1
De Giusti, M1
Farcomeni, A1
Abbolito, S1
Comito, F1
Cangianiello, S1
Greco, ES1
Dito, E1
Pagliaro, B1
Cotugno, M1
Stanzione, R1
Marchitti, S1
Bianchi, F1
Di Castro, S1
Battistoni, A1
Burocchi, S1
Caprinozzi, M1
Pierelli, G1
Sciarretta, S1
Volpe, M1
Rajpurohit, N1
Ayaz, SZ1
Yee, J1
Khan, MA1
Stys, A1
Barbieri, L1
Verdoia, M1
Schaffer, A1
Marino, P1
De Luca, G1
Rivera, CM1
Copeland, LA1
McNeal, CJ1
Mortensen, EM1
Pugh, MJ1
MacCarthy, DJ1
Medagama, A1
Bandara, R1
De Silva, C1
Galgomuwa, MP1
Beauloye, C1
Vrolix, M1
Claeys, MJ1
van de Borne, P1
Vandendriessche, E1
Van De Werf, F4
Hagström, E1
Roe, MT6
Hafley, G1
Neely, ML1
Sidhu, MS1
Winters, KJ2
Prabhakaran, D4
White, HD10
Armstrong, PW10
Fox, KA15
Ohman, EM7
Boden, WE3
Buccheri, D1
Minacapelli, A1
Piraino, D1
La Grutta, L1
Andolina, G1
Cornel, JH5
Neely, B2
Jakubowski, JA2
Bhatt, DL7
Ardissino, D3
Erlinge, D2
Tantry, US2
Gurbel, PA3
Yan, FF3
Liu, YF3
Liu, Y3
Zhao, YX3
Moliterno, DJ6
Li, JB1
Dong, HM1
Jian, Z1
Wu, XJ1
Zhao, XH1
Yu, SY1
Huang, L1
Wang, TY1
Ou, FS1
Harrington, RA7
Gibler, WB3
Peterson, ED2
Guerra, M1
Mota, JC1
Veloso, M1
Gama, V1
Vouga, L1
Sarkees, ML1
Bavry, AA1
Acikel, S1
Yildirir, A1
Aydinalp, A1
Bal, U1
Kaynar, G1
Ozin, B1
Muderrisoglu, H1
Unger, EF1
Venkitachalam, L1
Kip, KE1
Mulukutla, SR1
Selzer, F1
Laskey, W1
Slater, J1
Cohen, HA1
Wilensky, RL2
Williams, DO3
Marroquin, OC1
Sutton-Tyrrell, K1
Bunker, CH1
Kelsey, SF1
Damman, P1
Hirsch, A2
Windhausen, F2
Tijssen, JG2
de Winter, RJ2
Zafar, MU1
Paz-Yepes, M1
Shimbo, D1
Vilahur, G1
Burg, MM2
Chaplin, W1
Fuster, V6
Davidson, KW2
Badimon, JJ4
Kojuri, J1
Mahmoody, Y1
Zangbar Sabegh, B1
Jannati, M1
Mahboodi, A1
Khalili, A1
Chen, YY1
Yi, CH1
Chen, CL1
Huang, SC1
Hsu, YH1
Zeymer, U1
Zahn, R2
Senges, J1
Gitt, A1
Ortega-Loayza, AG1
Raza, S1
Minisi, AJ1
Topaz, O1
Heller, A1
Jovin, IS1
Husted, SE3
Nielsen, HK1
Merella, P1
Casu, G1
Meloni, I1
Good, CW1
Berger, PB3
Radke, PW1
Alexander, JH2
Lopes, RD1
James, S1
Kilaru, R1
He, Y1
Mohan, P1
Goodman, S2
Verheugt, FW7
Flather, M2
Huber, K5
Liaw, D1
Lopez-Sendon, J2
De Caterina, R3
Jansky, P1
Darius, H3
Vinereanu, D1
Cools, F1
Atar, D1
Leiva-Pons, JL2
Keltai, M1
Ogawa, H5
Pais, P1
Parkhomenko, A2
Ruzyllo, W3
Diaz, R2
White, H2
Ruda, M1
Geraldes, M1
Lawrence, J1
Wallentin, L11
Hoshida, S1
Yuasa, F1
Lim, YJ1
Kijima, Y1
Iwasaka, J1
Iwasaka, T1
Braunwald, E8
Vassilev, D1
Hazan, M1
Dean, L1
Jia, XQ1
Dong, CM1
Qin, J1
Kourlaba, G1
Fragoulakis, V1
Maniadakis, N1
Kilickesmez, KO1
Kocas, C1
Abaci, O1
Okcun, B1
Gorcin, B1
Gurmen, T1
May, CH1
Lincoff, AM4
Goodman, SG5
Clemmensen, P1
Martinez, F1
Nicolau, JC3
Dalby, AJ1
McGuire, DK4
Gottlieb, S1
Topacio, GO1
Hamm, C1
Pavlides, G1
Goudev, AR1
Oto, A1
Tseng, CD1
Merkely, B1
Gasparovic, V1
Corbalan, R2
Cinteză, M1
McLendon, RC1
Brown, EB1
Lokhnygina, Y2
Aylward, PE4
Hochman, JS5
Neely, M1
Chan, MY1
Brown, E1
Zhou, C1
Klein, W4
Brieger, D1
Steg, PG2
Dabbous, O1
Avezum, A1
Natarajan, M5
Loma-Osorio, A1
García-Castrillo, L1
Arós, F1
Lopetegui, P1
Recuerda, E1
Epelde, F1
Alberts, MJ2
Easton, JD1
McRedmond, J1
Fitzgerald, D1
Orford, JL2
Lennon, R1
Melby, S2
Fasseas, P2
Bell, MR1
Rihal, CS1
Holmes, DR5
Howard, PA1
Grenier, O2
Cambou, JP2
Ferrières, J2
Thomas, D3
Amelineau, E2
Cantet, C2
Danchin, N3
Niiazova-Karben, ZA1
Sidorenko, BA1
Batyraliev, TA1
Preobrazhenskiĭ, DV1
Pershukov, IV1
Pia, IuV1
Daniiarov, BS1
Theroux, P9
Cipollone, F3
Ganci, A1
Greco, A2
Panara, MR2
Pasquale, M2
Di Gregorio, D2
Porreca, E1
Mezzetti, A1
Cuccurullo, F3
Patrignani, P4
Mateos-Cáreres, PJ1
García-Méndez, A1
Farré, J1
Sánchez de Miguel, L1
Gómez, J1
de Andres, R1
Rico, L1
Romero, J1
López-Farré, A1
Grand, A1
Moustapha, A1
Anderson, HV2
Collet, JP2
Montalescot, G3
Fine, E1
Golmard, JL1
Dalby, M1
Choussat, R2
Ankri, A2
Dumaine, R1
Lesty, C1
Vignolles, N1
Hughes, K1
Yusuf, S8
Zhao, F3
Gersh, BJ2
Commerford, PJ2
Blumenthal, M1
Budaj, A1
Wittlinger, T1
Gille, J1
Bernotat, J1
Böhm, S1
Behrens, P1
Löhr, JF1
Gharbi, M1
Barakett, N1
Lahidheb, DH1
Smiri, Z1
Fehri, W1
Azzouzi, F1
Rahal, N1
Mhenni, H1
Haouala, H1
Guediche, M1
Gerschutz, GP1
Hanania, G1
Vaur, L1
Guéret, P1
Blanchard, D1
Genès, N1
Lablanche, JM1
Maurin, T1
Zeller, M1
Cottin, Y1
Touzery, C1
Beer, JC1
L'Huillier, I1
Fraison, M1
Buffet, P1
Louis, P1
Wolf, JE1
Damås, JK2
Waehre, T2
Yndestad, A2
Otterdal, K2
Hognestad, A1
Solum, NO1
Gullestad, L2
Frøland, SS2
Aukrust, P2
Biviano, AB1
Rabbani, LE1
Paultre, F1
Hurley, E1
Sullivan, J1
Giglio, J1
Mosca, L1
Fries, R1
Böhm, M1
Kopp, CW1
Steiner, S1
Priglinger, U1
Christ, G1
Probst, P1
Maurer, G1
Minar, E1
Okmen, E1
Cakmak, M1
Tartan, Z1
Cam, N1
Kennon, S2
Price, CP2
Mills, PG2
Macey, M1
Cooper, J2
Clarke, H2
Timmis, AD2
Peters, RJ1
Lewis, BS1
Kopecky, SL1
Valentin, V2
Wodlinger, AM1
Pieper, JA1
Averkov, OV3
Slavina, NN1
Gratsianskiĭ, NA4
Srichai, MB1
Jaber, WA1
Prior, DL1
Marso, SP1
Houghtaling, PL1
Menon, V1
Simoons, ML7
Lange, RA1
Hillis, LD3
Manoharan, G1
Adgey, AA1
Teal, PA1
Sabatine, MS1
Morrow, DA1
Giugliano, RP2
Murphy, SA4
Demopoulos, LA2
DiBattiste, PM3
Weintraub, WS4
McCabe, CH5
Antman, EM7
Cannon, CP12
Faraday, N1
Braunstein, JB1
Heldman, AW1
Bolton, ED1
Chiles, KA1
Gerstenblith, G3
Schulman, SP5
Burger, K1
Steinhubl, SR4
Kimura, K1
Kosuge, M1
Rodgers, JE1
Camerini, A1
Chieffo, C1
Griffo, R1
Comaschi, M1
Gattone, M1
Mannucci, E1
Faglia, E1
Giorda, C1
Biorci, ML1
Fattirolli, F1
Arjomand, H1
Cohen, M9
Ezekowitz, MD1
Bakhritdinov, FSh1
Kamilov, ShM1
Trynkin, AV1
Babadzhanov, SA1
Kandzari, DE1
Banas, JS1
Gawaz, M1
Müller, I1
Besta, F1
Aghababian, RV1
Peters, R1
Lakkis, N2
Kerr, JL1
Oppelt, TF1
Rowen, RC1
Kassem-Moussa, H1
Mahaffey, KW2
Graffagnino, C2
Tasissa, G1
Sila, CA1
Simes, RJ1
Califf, RM11
Bhapkar, MV3
Newby, LK8
Rupprecht, HJ2
Hirsh, J4
Melero, JM1
Porras, C1
Such, M1
Olalla, E1
Alonso, J1
Stejskal, D1
Prosková, J1
Lacnák, B1
Horalík, D1
Hamplová, A1
Oral, I1
Hrabovská, I1
Ochmanová, R1
Adamovská, S1
Juráková, R1
Ozanová, G1
Juchelka, J1
Kulísková, O1
Pĕnkavová, H1
Michelson, AD1
Chesebro, JH7
Karha, J1
Gibson, CM3
Sonson, JM1
Lum, JJ1
Madison, JR1
Seto, TB1
Spies, C1
Kumana, CR1
Cheung, G1
Lauder, IJ1
Cheung, BM1
Campbell, CL1
Schleinitz, MD1
Heidenreich, PA1
Lim, MJ1
Spencer, FA2
Gore, JM2
Dabbous, OH2
Agnelli, G2
Kline-Rogers, EM1
Dibenedetto, D1
Eagle, KA2
Mehta, RH2
Pettersen, AA1
Seljeflot, I1
Abdelnoor, M1
Arnesen, H1
Aranki, S1
Byrne, J1
Bhatia, D1
Mehta, S1
Mills, R1
Elsässer, A1
Nef, H1
Möllmann, H1
Hamm, CW1
Akowuah, E1
Shrivastava, V1
Jamnadas, B1
Hopkinson, D1
Sarkar, P1
Storey, R1
Braidley, P1
Cooper, G1
James, SK1
Oldgren, J1
Lindbäck, J1
Johnston, N1
Siegbahn, A1
Sick, PB1
Brosteanu, O1
Ulrich, M1
Thiele, H1
Niebauer, J1
Busch, I1
Schuler, G1
Granger, CB4
Peterson, E1
Kline-Rogers, E1
Allegrone, J1
Dibra, A1
Mehilli, J1
Braun, S1
Hadamitzky, M1
Baum, H1
Dirschinger, J1
Schühlen, H1
Schömig, A1
Kastrati, A1
Trappe, HJ1
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Hornberger, W1
Zehender, H1
Roberts, R1
Joelson, JM1
Degré, SG1
Fang, ZY1
Sobolski, J1
Abramowicz, M1
Unger, P1
Berkenboom, G1
Boem, A1
Gazzetti, P1
Sicari, R1
Giannessi, D1
Rutherford, JD1
Chard, RB1
Kam, CA1
Nunn, GR1
Johnson, DC1
Meldrum-Hanna, W1
Charvát, J2
Fiserová, J1
Hockings, B1
Cox, RA1
Penkov, N1
Sirakova, V1
Kristensen, SD1
Bath, PM1
Vejar, M2
Fragasso, G1
Hackett, D2
Lipkin, DP1
Bunnell, P2
Tenney, RD1
McNulty, A2
Kikel, M2
Miller, DH2
Zola, BE1
Tracy, R1
Stump, D1
Ianetti, M1
Galassi, AR1
Lipkin, D1
Oates, JA1
von Dohlen, TW1
Rogers, WB1
Frank, MJ1
Silberberg, JS1
McGregor, M1
Kuruvilla, T1
Fluch, N1
Dusleag, J1
Weinrauch, V1
Rotman, B1
Gasser, R1
Kronberger-Schaffer, E1
Castaigne, A1
Duval-Moulin, AM1
Dutoit, C1
Devereux, RB1
Tenney, R1
Zola, B1
Borhani, NO1
Hugenholtz, PG1
Cohen, LS1
Luchi, RJ1
Scott, SM1
Deupree, RH1
Leeman, DE1
Faxon, DP1
Lorell, BH1
Kellett, MA1
McKay, RG1
Varricchione, T1
Baim, DS1
Seth, A1
Perry, RA1
Shiu, MF1
Slany, J1
Hamad, JF1
Wittes, J1
Friedman, L1
Ouimet, H1
Latour, JG1
Joly, P1
Lévy, G1
Pelletier, E1
Stasiak, J1
deGuise, P1
Petch, MC1
Panetta, A1
Pinto, S1
Favilla, S1
Rehr, RB1
DiSciascio, G1
Cowley, MJ1
Hansen, JF1
Hansen, BF1
Resnekov, L1
Chediak, J1
Lewis, D1
Nicolas, G1
Orlov, VA1
Iakunin, GA2
Khishtovani, AI2
Bates, ER1
Mickelson, JK1
Winniford, M1
Dmitriev, AA1
Kormer, AIa1
Oelz, O1
Gent, M1
Singer, J1
Finnie, KJ1
Froggatt, GM1
Holder, DA1
Jablonsky, G1
Kostuk, WJ1
Melendez, LJ1
Myers, MG1

Clinical Trials (27)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Long-term Follow-up of Antithrombotic Management Patterns in Acute Coronary Syndrome Patients[NCT01171404]10,568 participants (Actual)Observational2010-09-30Completed
A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects With Unstable Angina/Non-ST-Elevation Myocardial Infarction Who Are Medically Managed[NCT00699998]Phase 39,326 participants (Actual)Interventional2008-06-30Completed
Apixaban for Prevention of Acute Ischemic Events - 2 A Phase 3, Randomized, Double-Blind, Evaluation of the Safety and Efficacy of Apixaban In Subjects With a Recent Acute Coronary Syndrome[NCT00831441]Phase 37,484 participants (Actual)Interventional2009-03-31Terminated
Effects of Edoxaban on Platelet Aggregation in Patients With Stable Coronary Artery Disease[NCT05122455]Phase 2/Phase 370 participants (Anticipated)Interventional2021-09-14Recruiting
Laboratory Implications of Non Obstructive Atherosclerotic Plaques Identified by Multiple Detector Coronary Angiotomography[NCT03632785]90 participants (Actual)Observational2017-03-27Completed
Gastrointestinal Ulceration in Patients on Dual Antiplatelet Therapy After Percutaneous Coronary Intervention[NCT00413309]30 participants (Anticipated)Interventional2006-04-30Completed
Clopidogrel After Surgery for Coronary Artery Disease (CASCADE Trial): Does Clopidogrel Prevent Saphenous Vein Graft Disease After Coronary Bypass?[NCT00228423]Phase 2113 participants (Actual)Interventional2006-05-31Completed
Efficacy Evaluation of Observation Unit Cardiac Magnetic Resonance Imaging (MRI) in Patients With Intermediate Risk Acute Chest Pain[NCT00869245]124 participants (Actual)Interventional2009-03-31Completed
Randomized Investigation of Chest Pain Diagnostic Strategies[NCT01035047]105 participants (Actual)Interventional2010-01-31Completed
Randomized Cost Comparison of Cardiac MRI Use in ED Patients With Chest Pain[NCT00678639]110 participants (Actual)Interventional2008-01-31Completed
Aspirin Non-responsiveness and Clopidogrel Endpoint Trial.[NCT00222261]Phase 41,001 participants (Actual)Interventional2003-04-30Completed
Maintenance Of aNtiplatElet Therapy in Patients With Coronary Stenting Undergoing Surgery[NCT03445273]1,800 participants (Anticipated)Observational [Patient Registry]2018-11-21Not yet recruiting
[NCT00000614]Phase 30 participants Interventional1998-09-30Completed
Variation Between Hospitals in Short-term Mortality After Acute Coronary Syndromes: A CALIBER Study[NCT01111071]316,648 participants (Actual)Observational2010-04-30Completed
Study of the Efficacy and Safety of Cilostazol in the Prevention of Ischemic Vascular Events in Diabetic Patients With Symptomatic Peripheral Artery Disease.[NCT02983214]Phase 4826 participants (Actual)Interventional2016-11-30Completed
Clinical Feature and Outcome of Angiographic Coronary Artery Disease in Chronic Kidney Disease Patients[NCT00651521]1,000 participants (Actual)Observational2009-04-30Active, not recruiting
Cardiac Magnetic Resonance Imaging Strategy for the Management of Patients With Acute Chest Pain and Detectable to Elevated Troponin[NCT01931852]312 participants (Actual)Interventional2013-09-30Completed
The Role of Multiple Electrode Aggregometry in Detection of Clopidogrel Resistance in Diabetic Patients With Coronary Artery Disease and Prediction of Clinical Outcomes. A Comparative-method, Non Interventional, Single Center Study.[NCT01991093]280 participants (Actual)Observational2014-06-30Completed
A Randomized, Open-label, Active-controlled, Parallel-group Study to Investigate the Platelet Inhibition of Ticagrelor Versus Clopidogrel in Patients With Stable Coronary Artery Disease and Type 2 Diabetes Mellitus After Recent Elective Percutaneous Coron[NCT02748330]Phase 440 participants (Actual)Interventional2016-06-30Completed
A Comparison of CS-747 and Clopidogrel in Acute Coronary Syndrome Subjects Who Are to Undergo Percutaneous Coronary Intervention[NCT00097591]Phase 313,619 participants (Actual)Interventional2004-11-30Completed
A Double Blind Randomized Control Trial of Post-Operative Low Molecular Weight Heparin Bridging Therapy Versus Placebo Bridging Therapy for Patients Who Are at High Risk for Arterial Thromboembolism (PERIOP 2)[NCT00432796]Phase 31,473 participants (Actual)Interventional2006-12-31Active, not recruiting
[NCT00000472]Phase 30 participants Interventional1989-04-30Completed
Study of the Efficacy, Safety and Tolerability of Low Molecular Weight Heparin vs. Unfractionated Heparin as Bridging Therapy in Patients With Embolic Stroke Due to Atrial Fibrillation[NCT02159287]Phase 280 participants (Anticipated)Interventional2014-01-31Recruiting
Uninterrupted Direct-acting Oral Anticoagulation in Patients Undergoing Transradial Percutaneous Coronary Procedures[NCT05292846]Phase 4200 participants (Anticipated)Interventional2022-01-20Recruiting
The Effect of Serum LDL Lowering on Aspirin Resistance[NCT00466154]40 participants Interventional2005-07-31Completed
WilL LOWer Dose Aspirin be More Effective Following ACS? (WILLOW-ACS)[NCT02741817]Phase 420 participants (Actual)Interventional2016-06-26Completed
A Clinical Trial of Conservative Versus Routine Invasive Management in Patients With Prior Coronary Artery Bypass Surgery in Patients With a Non-ST Elevation Acute Coronary Syndrome: a Pilot Trial and Registry.[NCT01895751]Phase 460 participants (Actual)Interventional2012-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Percentage of Participants With a Composite Endpoint of All-cause Death, MI, or Stroke

The percentage of participants is the total number of participants experiencing an all-cause death, nonfatal MI, or nonfatal stroke divided by number of participants in the treatment arm. Endpoint events were adjudicated by the Clinical Endpoint Committee. (NCT00699998)
Timeframe: Randomization through end of study (30-month visit)

Interventionpercentage of participants with an event (Number)
Prasugrel: <75 Years of Age10.61
Prasugrel: 75 Years of Age or Older27.04
Clopidogrel: <75 Years of Age11.12
Clopidogrel: 75 Years of Age or Older26.83

Percentage of Participants With a Composite Endpoint of Cardiovascular (CV) Death, Myocardial Infarction (MI), or Stroke

The percentage of participants is the total number of participants experiencing a CV death, nonfatal MI, or nonfatal stroke divided by number of participants in the treatment arm multiplied by 100. Endpoint events were adjudicated by the Clinical Endpoint Committee. (NCT00699998)
Timeframe: Randomization through end of study (30-month visit)

Interventionpercentage of participants with an event (Number)
Prasugrel: <75 Years of Age10.06
Prasugrel: 75 Years of Age or Older24.64
Clopidogrel: <75 Years of Age10.96
Clopidogrel: 75 Years of Age or Older24.13

Percentage of Participants With a Composite Endpoint of CV Death and MI

The percentage of participants is the total number of participants experiencing a CV death or nonfatal MI divided by number of participants in the treatment arm. Endpoint events were adjudicated by the Clinical Endpoint Committee. (NCT00699998)
Timeframe: Randomization through end of study (30-month visit)

Interventionpercentage of participants with an event (Number)
Prasugrel: <75 Years of Age9.61
Prasugrel: 75 Years of Age or Older22.53
Clopidogrel: <75 Years of Age10.21
Clopidogrel: 75 Years of Age or Older22.69

Percentage of Participants With a Composite Endpoint of CV Death, MI, Stroke, or Re-hospitalization for Recurrent Unstable Angina (UA)

The percentage of participants is the total number of participants experiencing a CV death, nonfatal MI, nonfatal stroke or re-hospitalization for a recurrent UA divided by number of participants in the treatment arm. Endpoints events were adjudicated by the Clinical Endpoint Committee. (NCT00699998)
Timeframe: Randomization through end of study (30-month visit)

Interventionpercentage of participants with an event (Number)
Prasugrel: <75 Years of Age12.13
Prasugrel: 75 Years of Age or Older26.27
Clopidogrel: <75 Years of Age12.83
Clopidogrel: 75 Years of Age or Older25.67

Biomarker Measurements of Inflammation/Hemodynamic Stress: Brain Natriuretic Peptide (BNP)

Brain natriuretic peptide (BNP) is secreted by the ventricles of the heart in response to hemodynamic stress and is a biomarker associated with increased CV risk. Results are presented as geometric least squares means (Geometric LS means). Geometric LS means were adjusted for treatment + baseline value + clopidogrel status at randomization. (NCT00699998)
Timeframe: Day 30 and 6 Months

,,,
Interventionpicograms per milliliter (pg/mL) (Geometric Mean)
Day 306 Months (n=725, 125, 701, 174)
Clopidogrel: <75 Years of Age319.345250.982
Clopidogrel: 75 Years of Age or Older951.359722.750
Prasugrel: <75 Years of Age313.494253.434
Prasugrel: 75 Years of Age or Older1082.396770.132

Biomarker Measurements of Inflammation/Hemodynamic Stress: C-Reactive Protein (CRP)

C-Reactive Protein (CRP) is a biomarker associated with inflammation and increased CV risk. Results are presented as geometric least squares means (Geometric LS means). Geometric LS means were adjusted for treatment + baseline value + clopidogrel status at randomization. (NCT00699998)
Timeframe: Day 30 and Month 6

,,,
Interventionmilligrams per liter (mg/L) (Geometric Mean)
Day 306 Months (n=755, 143, 745, 178)
Clopidogrel: <75 Years of Age2.2872.149
Clopidogrel: 75 Years of Age or Older2.2261.543
Prasugrel: <75 Years of Age2.3302.272
Prasugrel: 75 Years of Age or Older2.4411.593

Economic and Quality of Life Outcomes

Seattle Angina Questionnaire (SAQ) is a validated, disease-specific questionnaire containing 11 questions (Q) yielding 5 summary scales related to angina: physical limitations, angina stability, angina frequency, treatment satisfaction and disease perception. In this study only angina frequency and the physical limitations scales were assessed. Anginal Frequency was assessed using Q3 and Q4 which consists of a Likert scale ranging from 1 to 6 (higher values equals better quality of life) to assess how often a patient is having symptoms now. Physical limitations was assessed using Q1 which contains 9 items each assessed via Likert scale ranging from 1 to 6 (higher values equals better quality of life) to assess how much a participant's condition is hampering their ability to do what they want to do. Scale scores are transformed to a 0-100 by subtracting the lowest possible score, dividing by the range of the scale, and multiplying by 100. Higher values equal better quality of life. (NCT00699998)
Timeframe: Baseline and follow-up (24 months)

,
Interventionunits on a scale (Mean)
Baseline, physical limitationsBaseline, angina frequency24 Months, physical limitations (n=420, 412)24 Months, angina frequency (n=420, 412)
Clopidogrel67.073.174.589.5
Prasugrel67.873.675.189.7

Genotyping Related to Drug Metabolism

Variation in the genes encoding the cytochrome P450 (CYP) enzymes (CYP2C19) can reduce the ability to metabolize clopidogrel and a reduced platelet response and have been associated with increased rates of CV events including CV death. Participants were classified as extensive metabolizers (EM); reduced metabolizers (RM); or unknown (UNK) metabolizers based on their CYP2C19 genotype. Possible extensive metabolizer (EM) phenotypes include EM=extensive metabolizer, UM=ultra-rapid metabolizer, and EM (non-UM) that are not UM. Possible reduced metabolizer (RM) phenotypes include IM=intermediate metabolizer and PM=poor metabolizer. Genotypes associated with each predicted phenotype are presented; predicted phenotype is presented first followed by the genotype. Percentage=(number of participants with the predicted phenotype and genotype divided by the total number of participants per arm) multiplied by 100. (NCT00699998)
Timeframe: Baseline

,,,
Interventionpercentage participants with geneotype (Number)
UM, *1/*17UM, *17/*17EM (non-UM), *1/*1IM, *1/*2IM, *1/*3IM, *1/*4IM, *1/*6IM, *1/*8PM, *2/*2PM, *2/*3PM, *2/*4PM, *2/*6PM, *2/*8PM, *3/*3UNK, *1/*10UNK, *1/*13UNK, *1/*9UNK, *1/*9, *9/*17UNK, *13/*17UNK, *2/*13UNK, *2/*17UNK, *2/*9UNK, *3/*17UNK, *4/*17UNK, *4/*9UNK, *6/*17UNK, *8/*17UNK, *9/*17UNK, Undefined genotype
Clopidogrel: <75 Years of Age25.15.435.719.80.50.10.00.44.30.30.20.00.00.20.10.00.00.00.00.06.80.10.00.20.00.00.10.00.5
Clopidogrel: 75 Years of Age or Older21.84.341.219.70.60.30.20.33.80.30.20.00.00.00.00.00.00.00.00.06.20.00.30.00.00.20.00.00.6
Prasugrel: <75 Years of Age24.05.138.818.60.80.40.00.13.90.30.00.00.00.00.00.00.10.00.00.06.30.00.10.20.00.00.20.00.7
Prasugrel: 75 Years of Age or Older25.03.642.118.30.60.00.20.52.20.20.20.00.00.00.00.20.20.00.00.06.10.00.00.20.00.00.00.00.6

Platelet Aggregation Measures

Platelet aggregation was measured by as measured by Accumetrics Verify Now™ P2Y12. Results were reported in P2Y12 Reaction Units (PRU). PRU represents the rate and extent of adenosine (ADP)-stimulated platelet aggregation. Lower values indicate greater P2Y12 platelet inhibition and lower platelet activity and aggregation. ANCOVA Model was used and values were corrected for treatment + baseline value + clopidogrel status at randomization. (NCT00699998)
Timeframe: Day 30 and 12 Months

,,,
InterventionP2Y12 Reaction Units (PRU) (Least Squares Mean)
Day 30Month 12 (n=386, 76, 400, 103)
Clopidogrel: <75 Years of Age193.489199.003
Clopidogrel: 75 Years of Age or Older200.285181.360
Prasugrel: <75 Years of Age93.28094.529
Prasugrel: 75 Years of Age or Older151.872135.096

Summary of All Deaths

All deaths, regardless of possible relatedness, with the exception of 1 event, were adjudicated by the Clinical Endpoint Committee (CEC) and are reported in this table. The 1 event which was not adjudicated was a result of the revocation of consent by the participant prior to their death. Deaths possibly related to study drug in the opinion of the investigator are also contained in the Serious Adverse Event (SAE) module. (NCT00699998)
Timeframe: Randomization through end of study (30-month visit)

,,,
Interventionparticipants (Number)
Congestive Heart FailureCardiogenic ShockCardiac RuptureMyocardial InfarctionDysrhythmiaStent ThrombosisDirectly Related to Revascularization-CABG or PCIIntracranial HemorrhageNon-Hemorrhagic StrokeSudden death due to cardiovascular eventPulmonary EmbolismStroke, unknown typeOther Cardiovascular EventCardiovascular event, unknown typeAccidentalTraumaHemorrhage, not intracranialInfectionMalignancySuicideOther Non-Cardiovascular eventCause unknown (nonadjudicated event)
Clopidogrel: <75 Years of Age13100246014470200451001614080
Clopidogrel: 75 Years of Age or Older2390213011343101451141711060
Prasugrel: <75 Years of Age1080165012475006401211414180
Prasugrel: 75 Years of Age or Older214124201143911141031217041

Event Rate of All Bleeding Reported by the Investigator During the Treatment Period - Treated Participants

Bleeding events were adjudicated by the Adjudication Committee and classified according to Thrombolysis in Myocardial Infarction (TIMI) major, minor, minimal, and International Society on Thrombosis and Hemostasis (ISTH) major and clinically relevant non-major bleeding (CRNM) criteria. The adjudicated results based on TIMI and ISTH classifications, and programmatically identified events (not adjudicated) according to Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) classification were used in the analyses of bleeding endpoints. GUSTO Bleed Criteria included Severe or life-threatening: Intracranial hemorrhage, or bleeding that causes hemodynamic compromise requiring intervention; Moderate: Bleeding that requires a blood transfusion, but does not result in hemodynamic compromise; Mild: Bleeding that does not meet criteria for either severe or moderate bleeding. Treatment Period=events with onset from first dose to last dose plus 2 days. (NCT00831441)
Timeframe: From first dose to first occurrence of event (Bleeding) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years

Interventionpercentage of participants/100-pt years (Number)
Placebo16.33
Apixaban 5 mg BID39.98

Event Rate of Cardiovascular Death, Myocardial Infarction, or Ischemic Stroke During the Intended Treatment Period - Randomized Participants

Event rate was percent of participants with an event of cardiovascular (CV) death, myocardial infarction (MI), or ischemic stroke (number of participants with event/number randomized) per 100 patient (100-pt) years. Study was terminated early and last patient, last visit was in Year 2. Only events confirmed by the adjudication committee were included in the analyses. CV death included deaths due to CV causes (eg, cardiogenic shock, heart failure, arrhythmia/sudden death, cardiac rupture, ischemic stroke, pulmonary embolism, venous/arterial thrombotic events) and other sudden deaths for which an alternative cause was not identified. Intended Treatment Period: the period that started on the day of randomization and ended at the efficacy cut-off date (cut-off date: the date all sites were informed that study drug should be discontinued for all participants, 18 November 2010). (NCT00831441)
Timeframe: Randomization (Day 1) to first event (CV death, MI, ischemic stroke), up to March 2011, approximately 2 years

Interventionpercentage of participants/100-pt years (Number)
Placebo13.96
Apixaban 5 mg BID13.20

Event Rate of Composite of All-Cause Death, Myocardial Infarction, or Stroke During the Intended Treatment Period - Randomized Participants

"Cause of death was determined by the principal condition that caused the death, not the immediate mode of death.~CV death: included deaths due to CV causes. Non-CV death: included non-CV deaths caused primarily by a malignancy, infection, bleeding, trauma, non-CV system organ failure, or non-CV surgery. Unknown: included deaths that were not attributable to one of the above categories of CV death or to a non-CV cause. MI accounted whether the participant had a recent PCI or CABG surgery. Diagnosis of stroke required a new, non-traumatic, focal neurological deficit of sudden onset, lasting at least 24 hours that was not due to a readily identifiable non-vascular cause. Only events confirmed by the adjudication committee were included in analyses. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off date (notification of study termination)." (NCT00831441)
Timeframe: Randomization (Day 1) to first event (All Cause Death, MI, or Stroke), up to March 2011, approximately 2 years

Interventionpercentage of participants/100-pt years (Number)
Placebo15.65
Apixaban 5 mg BID15.48

Event Rate of Composite of Cardiovascular Death, Fatal Bleed, Myocardial Infarction, or Stroke During the Intended Treatment Period - Randomized Participants

Event rate was percent of participants with an event of CV death, fatal bleed, MI, or stroke (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. CV death included deaths due to CV causes; Diagnosis of stroke required a new, non-traumatic, focal neurological deficit of sudden onset, lasting at least 24 hours that was not due to a readily identifiable non-vascular cause; Fatal bleeding defined as bleeding that Adjudication Committee determined was the primary cause of death or contributed directly to death; MI took into account whether the participant had a recent PCI or CABG surgery. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off date (notification of study termination). (NCT00831441)
Timeframe: Randomization (Day 1) to first event (CV death, Fatal Bleed, MI, or stroke), up to March 2011, approximately 2 years

Interventionpercentage of participants/100-pt years (Number)
Placebo14.27
Apixaban 5 mg BID13.97

Event Rate of Composite of Cardiovascular Death, Myocardial Infarction, Unstable Angina, or Ischemic Stroke During the Intended Treatment Period - Randomized Participants

Event rate was percent of participants with an event of CV death, MI, unstable angina (UA), or ischemic stroke (number of participants with event/number randomized) per 100-pt years. Only events confirmed by the adjudication committee were included in the analyses. Each type of event was counted once per participant, but participants could have been counted in multiple categories. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off date (notification of study termination). (NCT00831441)
Timeframe: Randomization (Day 1) to first event (CV death, MI, UA, Ischemic Stroke, up to March 2011, approximately 2 years

Interventionpercentage of participants/100-pt years (Number)
Placebo17.95
Apixaban 5 mg BID16.92

Event Rate of Confirmed Major Bleeding or Clinically Relevant Non-Major Bleeding (CRNM) Using ISTH Criteria During the Treatment Period - Treated Participants

ISTH Major bleed: acute clinically overt bleeding accompanied by one or more of the following: A decrease in Hgb of 2 g/dL or more over 24 hours; A transfusion of 2 or more units of packed RBCs; Bleeding that occurs in at least one of the following critical sites: intracranial, intraspinal, intraocular (within the corpus of the eye), pericardial, intra-articular, intramuscular with compartment syndrome, retroperitoneal; Bleeding that was fatal. CRNM: acute clinically overt bleeding that did not satisfy additional criteria required for the bleeding event to be defined as a major bleeding event and meets at least one of the following: Hospital admission for bleeding; Physician guided medical or surgical treatment for bleeding; Change in anti-thrombotic treatment (anticoagulant or antiplatelet) therapy. Bleeding events were adjudicated by the Adjudication Committee. Treatment Period=events with onset from first dose to last dose plus 2 days. (NCT00831441)
Timeframe: From first dose to first occurrence of event (ISTH major or CRNM bleed) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years

Interventionpercentage of participants/100-pt years (Number)
Placebo2.29
Apixaban 5 mg BID6.15

Event Rate of Confirmed Major Bleeding Using International Society on Thrombosis and Hemostasis (ISTH) Criteria During the Treatment Period - Treated Participants

ISTH Criteria: Acute clinically overt bleeding defined as new onset, visible bleeding or signs or symptoms suggestive of bleeding confirmed by imaging techniques, which can detect the presence of blood (eg, ultrasound, CT, MRI). Major bleeding: acute clinically overt bleeding accompanied by one or more of the following: A decrease in Hgb of 2 g/dL or more over 24 hours; A transfusion of 2 or more units of packed red blood cells (RBCs); Bleeding that occurs in at least one of the following sites: intracranial, intraspinal, intraocular (within the corpus of the eye; thus, a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, retroperitoneal; Bleeding that was fatal. Bleeding events were adjudicated by the Adjudication Committee. Event rate was percent of participants with an event (number with event/number randomized) per 100-pt years. Treatment Period=events with onset from first dose to last dose plus 2 days. (NCT00831441)
Timeframe: From first dose to first occurrence of event (ISTH major bleed) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years

Interventionpercentage of participants/100-pt years (Number)
Placebo2.04
Apixaban 5 mg BID5.13

Event Rate of Confirmed Major Bleeding Using Thrombolysis in Myocardial Infarction (TIMI) Criteria During the Treatment Period - Treated Participants

TIMI Major Bleed Criteria: Fatal bleeding, intracranial hemorrhage, and clinically overt bleeding with a hemoglobin (Hgb) drop of ≥ 5 grams per deciliter (g/dL), or ≥15% absolute decrease in hematocrit. To account for transfusions, Hgb measurements were adjusted for transfusions. A transfusion of 1 unit of blood was assumed to result in an increase by 1 g/dL in Hgb or 3% in hematocrit. Event rate was percent of participants with an event of Major Bleed as per TIMI (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. Treatment Period=events with onset from first dose to last dose plus 2 days. (NCT00831441)
Timeframe: From first dose to first occurrence of event (TIMI major bleeding) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years

Interventionpercentage of participants/100-pt years (Number)
Placebo0.91
Apixaban 5 mg BID2.40

Event Rate of Myocardial Infarction (MI) During the Intended Treatment Period - Randomized Participants

MI took into account whether the participant had a recent percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery. Selected key criteria: Elevation of cardiac biomarkers (eg, Creatine Kinase MB fraction (CKMB), Troponin T, Troponin I) above the upper reference limit (URL) plus ischemic symptoms, ECG changes, or imaging evidence of new loss of viable myocardium or new regional wall motion abnormality; Death of CV etiology with new ST-segment elevation or left bundle branch block (LBBB) or fresh intracoronary thrombus by angiography or at autopsy occurring before biomarkers could be obtained or before their appearance in the blood; Following a PCI, elevation of cardiac biomarkers more than 3*URL; Following CABG surgery, elevation of cardiac biomarkers more than 5*URL; New, significant (≥0.04 s) Q waves in ≥2 contiguous leads; Pathologic findings of acute MI. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off notice. (NCT00831441)
Timeframe: Randomization (Day 1) to first event (MI), up to March 2011, approximately 2 years

Interventionpercentage of participants/100-pt years (Number)
Placebo9.20
Apixaban 5 mg BID8.59

Event Rate of Stent Thrombosis During the Intended Treatment Period - Randomized Participants

Stent thrombosis: Definite stent thrombosis considered to have occurred by either angiographic or pathological confirmation; Probable stent thrombosis considered to have occurred in the following cases: any unexplained death within the first 30 days after stent implantation; irrespective of the time after the procedure, any MI that was related to documented acute ischemia in the territory of the implanted stent without angiographic confirmation of stent thrombosis and in the absence of any other obvious cause; Possible stent thrombosis considered to have occurred with any unexplained death from 30 days after intracoronary stenting until end of study (in Year 2). Event rate was percent of participants with an event of stent thrombosis (number with event/number randomized) per 100-pt years. Only events confirmed by the adjudication committee were included in the analyses. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off notice of study termination. (NCT00831441)
Timeframe: Randomization (Day 1) to first event (stent thrombosis), up to March 2011, approximately 2 years

Interventionpercentage of participants/100-pt years (Number)
Placebo2.21
Apixaban 5 mg BID1.61

Event Rate of Stroke During the Intended Treatment Period - Randomized Participants

Event rate was percent of participants with an event of stroke (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. Diagnosis of stroke required a new, non-traumatic, focal neurological deficit of sudden onset, lasting at least 24 hours that was not due to a readily identifiable non-vascular cause (ie, brain tumor). All strokes were classified as hemorrhagic (documentation on imaging (eg computed tomography scan or magnetic resonance imaging) of hemorrhage in the cerebral parenchyma, or a subdural or subarachnoid hemorrhage), non-hemorrhagic/ischemic stroke, ischemic stroke with hemorrhagic conversion, or type unknown. Intended Treatment Period: the period that started on the day of randomization (Day 1) and ended at the efficacy cut-off date (notification of study termination). (NCT00831441)
Timeframe: Randomization (Day 1) to first event (stroke), up to March 2011, approximately 2 years

Interventionpercentage of participants/100-pt years (Number)
Placebo1.85
Apixaban 5 mg BID1.65

Event Rate of Unstable Angina (UA) During the Intended Treatment Period - Randomized Participants

Unstable Angina (UA) defined as worsening or recurrent severe or repetitive angina symptoms at rest lasting at least 10 minutes with at least 2 of the following: New and dynamic electrocardiogram (ECG) changes; angina symptoms leading to inpatient hospitalization; angina symptoms leading to an unplanned or urgent cardiac catheterization, with or without revascularization, that showed evidence of hemodynamically and clinically significant stenosis. Event rate was percent of participants with an event of unstable angina (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. Intended Treatment Period: the period that started on the day of randomization and ended at the efficacy cut-off date (cut-off date: the date all sites were informed that study drug should be discontinued for all participants, 18 November 2010). (NCT00831441)
Timeframe: Randomization (Day 1) to first event of UA, up to March 2011, approximately 2 years

Interventionpercentage of participants/100-pt years (Number)
Placebo4.21
Apixaban 5 mg BID3.95

Incidence of Major Adverse Coronary Events Within One Year Following Surgery

(NCT00228423)
Timeframe: 1 year

InterventionParticipants (Count of Participants)
75mg Clopidogrel4
Placebo5

Incidence of Major Bleeding Events Within One Year Following Surgery

(NCT00228423)
Timeframe: 1 year

InterventionParticipants (Count of Participants)
75mg Clopidogrel1
Placebo0

Vein Graft Angiographic Patency

Postoperative angiogram 12 months post-CABG (NCT00228423)
Timeframe: One year following surgery

Interventionpercentage (Number)
75mg Clopidogrel94.3
Placebo93.2

Vein Graft Intimal Area

IVUS imaging 12 months post-CABG, and the average intimal area in the proximal 40 mm of one vein graft per patient will be assessed (NCT00228423)
Timeframe: One year following surgery

Interventionmm (Mean)
75mg Clopidogrel4.1
Placebo4.5

Acute Coronary Syndrome

(NCT01035047)
Timeframe: Index Hospitalization discharge through 90 days

Interventionparticipants (Number)
CDU-CMR Protocol0
Inpatient Care3

Length of Stay

(NCT01035047)
Timeframe: Duration of Index Hospitalization, an average of 1-2 days

Interventionhours (Median)
CDU-CMR Protocol21.1
Inpatient Care26.3

Mortality

(NCT01035047)
Timeframe: Index Hospitalization through 90 days

Interventionparticipants (Number)
CDU-CMR Protocol0
Inpatient Care0

Stress Testing-related Adverse Event

(NCT01035047)
Timeframe: Index Hospitalization through 90 days

Interventionparticipants (Number)
CDU-CMR Protocol1
Inpatient Care0

The Composite of Revascularization, Re-hospitalization, and Recurrent Cardiac Testing Through 90 Days.

(NCT01035047)
Timeframe: Index Hospitalization through 90 days

Interventionparticipants (Number)
CDU-CMR Protocol7
Inpatient Care20

Adverse Events During Magnetic Resonance Imaging (MRI) Scanning

Any event leading to early termination of the MRI acquisition, or requiring intervention by a physician, will be considered an adverse event related to MRI, excluding physician termination of image acquisition due to concerns of cardiac ischemia. (NCT00678639)
Timeframe: Occuring in the MRI scanning suite or within 30 minutes of the last image acquisition.

InterventionParticipants (Number)
Emergency Department (ED) Observation Unit3
Usual Care1

Correct Admission Decision, Based Upon the Reference Standard of Acute Coronary Syndrome (ACS) at 30 Days

Participants with ACS and admitted or not experiencing ACS and discharged will be considered a correct admission decision. Remaining participants will be considered to have incorrect admission decisions. (NCT00678639)
Timeframe: 30 Days

InterventionParticipants (Number)
Emergency Department (ED) Observation Unit43
Usual Care6

Cost of Index Hospitalization

Index hospitalization refers to the hospital visit during which the participant was enrolled in the trial. The primary outcome is examining the cost for this visit. (NCT00678639)
Timeframe: Emergency Department (ED) arrival through hospital discharge, median length of stay was 28.1 hours

InterventionUS Dollars (Median)
Emergency Department (ED) Observation Unit2062
Usual Care2680

The Number of Participants Randomized to the OU and Were Able to Complete CMR Imaging

The number of participants able to complete the planned imaging sequences will be measured. (NCT00678639)
Timeframe: Emergency Department (ED) arrival through hospital discharge

InterventionParticipants (Number)
Emergency Department (ED) Observation Unit46

Number of Participants Who Utilized the Indicated Health Care Procedures

Measured as self report, assessed during telephone follow-up. (NCT00678639)
Timeframe: 30d, 3mo, 6mo, and 1 year

,
InterventionParticipants (Number)
Cardiac related office visitCardiac related ED visitCardiac related hospitalizationCardiac related proceduresCardiac CatheterizationStress TestResting Echocardiogram
Emergency Department (ED) Observation Unit7000000
Usual Care4434311

Number of Subjects Reaching the Composite Endpoint of All-Cause Death, Nonfatal Myocardial Infarction (MI), or Nonfatal Stroke

The endpoint in this measure is a combination of all-cause death, nonfatal MI, or nonfatal stroke. Results are reported for the All ACS population. (NCT00097591)
Timeframe: Randomization up to 15 months

InterventionParticipants (Number)
Prasugrel692
Clopidogrel822

Number of Subjects Reaching the Composite Endpoint of Cardiovascular (CV) Death, Nonfatal Myocardial Infarction (MI), Nonfatal Stroke, or Rehospitalization for Cardiac Ischemic Events

The endpoint in this measure is a combination of CV death, nonfatal MI, nonfatal stroke, or rehospitalization for cardiac ischemic events. Results are reported for the All ACS population. (NCT00097591)
Timeframe: Randomization up to 15 months

InterventionParticipants (Number)
Prasugrel797
Clopidogrel938

Number of Subjects Reaching the Composite Endpoint of Cardiovascular (CV) Death, Nonfatal Myocardial Infarction (MI), or Nonfatal Stroke

The endpoint in this measure is a combination of CV death, nonfatal MI, or nonfatal stroke. Results are reported for the All ACS population for the 30 and 90 day periods. (NCT00097591)
Timeframe: Randomization to 30 days; randomization to 90 days

,
InterventionParticipants (Number)
All ACS (Through 30 days)All ACS (Through 90 days)
Clopidogrel502573
Prasugrel389462

Number of Subjects Reaching the Composite Endpoint of Cardiovascular (CV) Death, Nonfatal Myocardial Infarction (MI), or Nonfatal Stroke

The endpoint in this measure is a combination of CV death, nonfatal MI, or nonfatal stroke. The data is presented by the study population, which is represented as follows: 1) subjects who presented with unstable angina and non-ST-segment elevation myocardial infarction (UA/NSTEMI), 2) subjects who presented with ST segment elevation myocardial infarction (STEMI), and 3) all subjects with acute coronary syndromes (ACS) (i.e. all subjects with UA/NSTEMI or STEMI). (NCT00097591)
Timeframe: Randomization up to 15 months

,
InterventionParticipants (Number)
UA/NSTEMI (n=5044, n=5030)STEMI (n=1769, n=1765)All ACS (n=6813, n=6795)
Clopidogrel565216781
Prasugrel469174643

Number of Subjects Reaching the Composite Endpoint of Cardiovascular (CV) Death, Nonfatal Myocardial Infarction (MI), or Urgent Target Vessel Revascularization (UTVR)

The endpoint in this measure is a combination of CV death, nonfatal MI, or UTVR. Results are reported for the All ACS subject population for the 30 and 90 day periods. (NCT00097591)
Timeframe: Randomization to 30 days; randomization to 90 days

,
InterventionParticipants (Number)
All ACS (Through 30 days)All ACS (Through 90 days)
Clopidogrel504588
Prasugrel399472

Number of Treated Subjects With Non-Coronary Artery Bypass Graft (CABG) Related Thrombolysis In Myocardial Infarction (TIMI) Study Group Major and Minor Bleeding Events

TIMI classification for major and minor bleeding in the subset of subjects who did not undergo a coronary artery bypass operation (CABG) were defined as follows: Major bleeding: any intracranial hemorrhage (ICH) OR any clinically overt bleeding (including bleeding evident on imaging studies) associated with a fall in hemoglobin (Hgb) of ≥5 grams/deciliter (gm/dL)from baseline. Minor Bleeding: any clinically overt bleeding associated with a fall in Hgb of ≥3 gm/dL but <5 gm/dL from baseline. Major bleeding events were further examined as events that were deemed life threatening and/or fatal. (NCT00097591)
Timeframe: First dose of study drug up to 15 months (while at risk)

,
InterventionParticipants (Number)
TIMI Major or Minor BleedingTIMI Major BleedingTIMI Major Bleeding - Life-threatening (LT)LT - FatalLT - Symptomatic intracranial hemorrage (ICH)LT - Requiring inotropesLT - Requiring surgical interventionLT - Requiring transfusion (>=4 units)TIMI Minor Bleeding
Clopidogrel2311115651781930125
Prasugrel303146852119211945164

Reviews

155 reviews available for aspirin and Angina, Unstable

ArticleYear
The Evolution of Antiplatelet Therapy After Percutaneous Coronary Interventions: A 40-Year Journey.
    The Canadian journal of cardiology, 2022, Volume: 38, Issue:10 Suppl1

    Topics: Acute Coronary Syndrome; Angina, Unstable; Aspirin; Canada; Clopidogrel; Drug Therapy, Combination;

2022
Use of antiplatelet drugs in the treatment of acute coronary syndromes.
    Cardiovascular & hematological disorders drug targets, 2013, Volume: 13, Issue:2

    Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Clinical Trials as Topi

2013
[Differentiated antiplatelet therapy for acute coronary syndromes].
    Deutsche medizinische Wochenschrift (1946), 2014, Volume: 139, Issue:4

    Topics: Acute Coronary Syndrome; Adenosine; Angina, Unstable; Aspirin; Blood Platelets; Clopidogrel; Hemorrh

2014
Role of platelet inhibition in microvascular surgery.
    Journal of reconstructive microsurgery, 2014, Volume: 30, Issue:9

    Topics: Angina, Unstable; Aspirin; Coronary Disease; Endothelium, Vascular; Free Tissue Flaps; Humans; Plate

2014
Review of acute coronary syndromes: diagnosis and management of unstable angina and non ST-elevation myocardial infarction.
    South Dakota medicine : the journal of the South Dakota State Medical Association, 2015, Volume: 68, Issue:2

    Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Angina, Unstable; Angiotensin-Converting Enzym

2015
Advances in antiplatelet therapy for ACS and PCI.
    Journal of interventional cardiology, 2008, Volume: 21 Suppl 1

    Topics: Acute Coronary Syndrome; Adenosine Monophosphate; Angina, Unstable; Aspirin; Blood Platelets; Cardia

2008
Acute coronary syndrome (unstable angina and non-ST elevation MI).
    BMJ clinical evidence, 2009, Jan-13, Volume: 2009

    Topics: Acute Coronary Syndrome; Acute Disease; Administration, Oral; Angina, Unstable; Aspirin; Calcium Cha

2009
[Unfractionated heparin and low molecular weight heparin for acute coronary syndromes--assessment of a Cochrane review].
    Ugeskrift for laeger, 2010, Oct-18, Volume: 172, Issue:42

    Topics: Acute Coronary Syndrome; Angina, Unstable; Anticoagulants; Aspirin; Evidence-Based Medicine; Fibrino

2010
P2Y12 antagonists in acute coronary syndrome: in whom should they be started, and when?
    Current cardiology reports, 2011, Volume: 13, Issue:4

    Topics: Acute Coronary Syndrome; Adenosine; Angina, Unstable; Aspirin; Humans; Integrin alpha2; Myocardial I

2011
[Acute myocardial infarction: diagnosis and treatment].
    Medizinische Monatsschrift fur Pharmazeuten, 2011, Volume: 34, Issue:3

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Electrocardiography; Emer

2011
Unstable angina and non-ST elevation myocardial infarction.
    American journal of respiratory and critical care medicine, 2012, May-01, Volume: 185, Issue:9

    Topics: Acute Coronary Syndrome; Adenosine; Angina, Unstable; Anticoagulants; Aspirin; Clopidogrel; Coronary

2012
Antiplatelet agents in ischemic heart disease.
    Handbook of experimental pharmacology, 2012, Issue:210

    Topics: Angina, Unstable; Aspirin; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardial Revascular

2012
Unstable angina.
    Clinical evidence, 2002, Issue:7

    Topics: Angina, Unstable; Aspirin; Drug Therapy, Combination; Fibrinolytic Agents; Heparin, Low-Molecular-We

2002
[Treatment of coronary insufficiency in diabetics: Part 2: acute coronary insufficiency].
    Annales de cardiologie et d'angeiologie, 1999, Volume: 48, Issue:2

    Topics: Acute Disease; Adrenergic beta-Antagonists; Angina, Unstable; Angioplasty, Balloon, Coronary; Angiot

1999
Contemporary view of the acute coronary syndromes.
    The Journal of invasive cardiology, 2003, Volume: 15, Issue:2

    Topics: Acute Disease; Angina, Unstable; Anticoagulants; Aspirin; Clinical Trials as Topic; Coronary Disease

2003
Unstable angina.
    Clinical evidence, 2002, Issue:8

    Topics: Angina, Unstable; Aspirin; Drug Therapy, Combination; Fibrinolytic Agents; Heparin, Low-Molecular-We

2002
Short- and long-term oral antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention.
    Journal of the American College of Cardiology, 2003, Feb-19, Volume: 41, Issue:4 Suppl S

    Topics: Acute Disease; Administration, Oral; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clop

2003
[Role of low-molecular-weight heparin in acute coronary syndromes].
    La Tunisie medicale, 2002, Volume: 80, Issue:12

    Topics: Acute Disease; Angina, Unstable; Anticoagulants; Aspirin; Coronary Disease; Drug Administration Sche

2002
Appropriate antiplatelet and antithrombotic therapy in patients with acute coronary syndromes: recent updates to the ACC/AHA guidelines.
    The Journal of invasive cardiology, 2002, Volume: 14 Suppl E

    Topics: Abciximab; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopid

2002
Low-dose aspirin in the primary prevention of cardiovascular disease: how to balance the benefits and the risks.
    Italian heart journal : official journal of the Italian Federation of Cardiology, 2003, Volume: 4, Issue:4

    Topics: Angina, Unstable; Aspirin; Coronary Disease; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ri

2003
[Update cardiology 2001/2002-part II. From unstable coronary syndrome to terminal heart failure].
    Medizinische Klinik (Munich, Germany : 1983), 2003, Jun-15, Volume: 98, Issue:6

    Topics: Abciximab; Acute Disease; Adrenergic beta-Antagonists; Angina, Unstable; Antibodies, Monoclonal; Ant

2003
Angina (unstable).
    Clinical evidence, 2003, Issue:9

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Heparin, Low-Molecular-Weight; Humans; Platelet Aggregation

2003
The role of clopidogrel in the management of acute coronary syndromes.
    Clinical therapeutics, 2003, Volume: 25, Issue:8

    Topics: Acute Disease; Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Disease; C

2003
Treatment of unstable angina pectoris/non-ST-segment elevation myocardial infarction in elderly patients.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2003, Volume: 58, Issue:10

    Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Angiotensin-Converting Enzyme Inhibitors; Antic

2003
Aspirin insensitive eicosanoid biosynthesis in cardiovascular disease.
    Thrombosis research, 2003, Jun-15, Volume: 110, Issue:5-6

    Topics: Angina, Unstable; Aspirin; Cardiovascular Diseases; Drug Resistance; Eicosanoids; Humans; Isoprostan

2003
Current management of unstable angina: lessons from the TACTICS-TIMI 18 trial.
    American journal of cardiovascular drugs : drugs, devices, and other interventions, 2002, Volume: 2, Issue:4

    Topics: Angina, Unstable; Angioplasty, Balloon; Aspirin; Dalteparin; Drug Therapy, Combination; Fibrinolytic

2002
Recent clinical trial results with antiplatelet therapy: implications in stroke prevention.
    Cerebrovascular diseases (Basel, Switzerland), 2004, Volume: 17 Suppl 3

    Topics: Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Humans; Myocardial Infarction; Pla

2004
[Drug therapy for patients with unstable angina].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2004, Feb-10, Volume: 93, Issue:2

    Topics: Abciximab; Adrenergic beta-Antagonists; Angina, Unstable; Antibodies, Monoclonal; Aspirin; Calcium C

2004
Clopidogrel's role in the management of atherosclerotic disease: a focus on acute coronary syndromes.
    Expert review of cardiovascular therapy, 2003, Volume: 1, Issue:4

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Arteriosclerosis; Aspirin; Clinical Trials as Topi

2003
Combination antithrombotic therapy with antiplatelet agents and anticoagulants for patients with atherosclerotic heart disease.
    The Journal of invasive cardiology, 2004, Volume: 16, Issue:5

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Coronary Artery Disease; Drug Therapy, Combination; Hemor

2004
Current concepts in the antithrombotic management of non-ST-elevation acute coronary syndromes.
    Current cardiology reports, 2004, Volume: 6, Issue:4

    Topics: Angina, Unstable; Aspirin; Clinical Trials as Topic; Coronary Artery Disease; Heparin, Low-Molecular

2004
Combined antithrombotic therapy for acute coronary syndrome.
    Seminars in vascular medicine, 2003, Volume: 3, Issue:2

    Topics: Administration, Oral; Angina, Unstable; Anticoagulants; Aspirin; Clopidogrel; Coronary Thrombosis; D

2003
Role of clopidogrel in unstable angina and non-ST-segment elevation myocardial infarction: from literature and guidelines to practice.
    Pharmacotherapy, 2004, Volume: 24, Issue:8

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Hemorrhage; Humans;

2004
Comparative benefits of clopidogrel and aspirin in high-risk patient populations: lessons from the CAPRIE and CURE studies.
    Archives of internal medicine, 2004, Oct-25, Volume: 164, Issue:19

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Comorbidity; Diabetes Mellitus; Humans; Hypercholesterolemia

2004
Platelet function testing in cardiovascular diseases.
    Circulation, 2004, Nov-09, Volume: 110, Issue:19

    Topics: Angina, Unstable; Aspirin; Cardiovascular Diseases; Case Management; Clopidogrel; Drug Resistance; H

2004
Acute coronary syndromes: pathogenesis, acute diagnosis with risk stratification, and treatment.
    The American heart hospital journal, 2004,Fall, Volume: 2, Issue:4 Suppl 1

    Topics: Acute Disease; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Exercise Test; Heparin; Hu

2004
Angina (unstable).
    Clinical evidence, 2003, Issue:10

    Topics: Angina, Unstable; Aspirin; Cardiac Catheterization; Heparin, Low-Molecular-Weight; Humans; Platelet

2003
Variability in response to aspirin: do we understand the clinical relevance?
    Journal of thrombosis and haemostasis : JTH, 2005, Volume: 3, Issue:4

    Topics: Acute Disease; Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials a

2005
Issues in the management of antiplatelet therapy in patients undergoing surgical revascularization. A roundtable discussion.
    The Journal of invasive cardiology, 2005, Volume: 17, Issue:5

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; C

2005
Clopidogrel in acute coronary syndrome: when, how much, how long?
    Zeitschrift fur Kardiologie, 2005, Volume: 94, Issue:6

    Topics: Acute Disease; Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Disease; D

2005
[Acute chest pain].
    Medizinische Klinik (Munich, Germany : 1983), 2005, Aug-15, Volume: 100, Issue:8

    Topics: Acute Disease; Adrenergic beta-Antagonists; Aged; Algorithms; Angina, Unstable; Angioplasty, Balloon

2005
Aspirin plus warfarin compared to aspirin alone after acute coronary syndromes: an updated and comprehensive meta-analysis of 25,307 patients.
    European heart journal, 2006, Volume: 27, Issue:5

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Drug Therapy, Combination; Humans; Myocardial Infarction;

2006
Best evidence topic report. Clopidogrel plus aspirin or aspirin alone in unstable angina.
    Emergency medicine journal : EMJ, 2006, Volume: 23, Issue:2

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhi

2006
[Secondary prevention of acute coronary syndromes: are we following correctly the guidelines?].
    Giornale italiano di cardiologia (2006), 2006, Volume: 7, Issue:3

    Topics: Acute Disease; Adrenergic beta-Antagonists; Algorithms; Angina, Unstable; Angiotensin-Converting Enz

2006
[Anti-platelet drugs (aspirin, ticlopidine, etc)].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64, Issue:4

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clinical Trials as Topic; Humans; Meta-An

2006
[Acute coronary syndrome risk management].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64, Issue:4

    Topics: Angina, Unstable; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Coronary Artery Disease; Humans

2006
[Antiplatelet therapy in acute coronary syndromes without ST segment elevation].
    Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2006, Volume: 6 Suppl 1

    Topics: Angina, Unstable; Aspirin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet

2006
Angina (unstable).
    Clinical evidence, 2005, Issue:14

    Topics: Angina, Unstable; Aspirin; Cardiac Catheterization; Clopidogrel; Heparin, Low-Molecular-Weight; Huma

2005
Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease.
    Vascular medicine (London, England), 2007, Volume: 12, Issue:2

    Topics: Angina, Unstable; Aspirin; Atherosclerosis; Biomarkers; Blood Platelets; Clopidogrel; Humans; Inflam

2007
Antithrombotic therapy and the transition to the catheterization laboratory in UA/NSTEMI.
    Minerva cardioangiologica, 2007, Volume: 55, Issue:5

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Th

2007
[Unstable angina].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Sep-28, Volume: Suppl 5 Pt 2

    Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Angina, Unstable; Angioplasty, Balloon, Corona

2007
Aspirin combined with clopidogrel (Plavix) decreases cardiovascular events in patients with acute coronary syndrome.
    American family physician, 2007, Dec-01, Volume: 76, Issue:11

    Topics: Acute Coronary Syndrome; Angina, Unstable; Aspirin; Clopidogrel; Coronary Artery Disease; Evidence-B

2007
[Therapy of chronic stable angina].
    Der Internist, 2008, Volume: 49, Issue:1

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitors; Aspirin;

2008
Translational therapeutics at the platelet vascular interface. Summary.
    Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:3

    Topics: Angina, Unstable; Animals; Aspirin; Blood Platelets; Clopidogrel; Disease Models, Animal; Drug Evalu

2008
Mechanisms contributing to precipitation of unstable angina and acute myocardial infarction: implications regarding therapy.
    The American journal of cardiology, 1984, Dec-01, Volume: 54, Issue:10

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon; Animals; Antic

1984
Percutaneous transluminal coronary angioplasty.
    The American journal of the medical sciences, 1984, Volume: 288, Issue:2

    Topics: Angina, Unstable; Angioplasty, Balloon; Animals; Aspirin; Calcium Channel Blockers; Coronary Artery

1984
New directions in anticoagulant and antiplatelet treatment.
    British heart journal, 1995, Volume: 74, Issue:4

    Topics: Angina, Unstable; Aspirin; Chronic Disease; Drug Therapy, Combination; Humans; Myocardial Infarction

1995
Cardiology--I: Treatment of myocardial infarction, unstable angina, and angina pectoris.
    BMJ (Clinical research ed.), 1994, Nov-19, Volume: 309, Issue:6965

    Topics: Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inh

1994
[Coronary disease: benefits of aspirin. What dose for which disease?].
    Annales de cardiologie et d'angeiologie, 1994, Volume: 43, Issue:4

    Topics: Adult; Aged; Angina, Unstable; Aspirin; Coronary Disease; Dose-Response Relationship, Drug; Female;

1994
Unstable angina: pathogenesis, diagnosis, and treatment.
    Current problems in cardiology, 1993, Volume: 18, Issue:3

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Calcium Chan

1993
Antiplatelet therapy--Part I.
    The Western journal of medicine, 1993, Volume: 158, Issue:4

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Cardiovascular Diseases; Coronary Artery Bypass; Coronar

1993
[Blood platelet aggregation inhibitors in the treatment of heart diseases].
    Nederlands tijdschrift voor geneeskunde, 1993, Aug-14, Volume: 137, Issue:33

    Topics: Angina, Unstable; Aspirin; Coronary Artery Disease; Coronary Disease; Dipyridamole; Humans; Platelet

1993
[The new frontier of antithrombotic therapy: ASA + warfarin, the ideal solution?].
    Giornale italiano di cardiologia, 1995, Volume: 25, Issue:9

    Topics: Angina, Unstable; Aspirin; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Myocardial Infarc

1995
Oral anticoagulant treatment with and without aspirin.
    Thrombosis and haemostasis, 1995, Volume: 74, Issue:1

    Topics: Administration, Oral; Angina, Unstable; Anticoagulants; Aspirin; Clinical Trials as Topic; Dipyridam

1995
Advances in antithrombotic therapy: novel agents.
    Thrombosis and haemostasis, 1995, Volume: 74, Issue:1

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Antithrombins; Aspirin; Clinical Trials as Topic;

1995
[Treatment of unstable angina pectoris].
    Duodecim; laaketieteellinen aikakauskirja, 1995, Volume: 111, Issue:8

    Topics: Adrenergic beta-Antagonists; Algorithms; Angina, Unstable; Aspirin; Calcium Channel Blockers; Drug T

1995
Prehospital administration of aspirin in patients with unstable angina and acute myocardial infarction.
    Archives of internal medicine, 1996, Jul-22, Volume: 156, Issue:14

    Topics: Angina, Unstable; Animals; Aspirin; Clinical Trials as Topic; Hospitalization; Humans; Myocardial In

1996
[Contemporary opinions on the use of aspirin, heparin and thrombolytic therapy in unstable angina pectoris--pathogenetic findings versus results of many clinical tests].
    Przeglad lekarski, 1996, Volume: 53, Issue:1

    Topics: Angina, Unstable; Angiography; Aspirin; Hemorrhage; Heparin; Humans; Thrombolytic Therapy; Thrombosi

1996
Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina. A meta-analysis.
    JAMA, 1996, Sep-11, Volume: 276, Issue:10

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Drug Therapy, Combination; Hemorrhage; He

1996
Coronary heart disease, unstable angina, PTCA: new indications for low molecular weight heparins?
    Thrombosis research, 1996, Volume: 81, Issue:2 Suppl

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Animals; Anticoagulants; Aspirin; Coronary Disease

1996
Recognition and treatment of unstable angina.
    Drugs, 1996, Volume: 52, Issue:2

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Aspirin; Guidelines as Topic; Humans; Platelet Aggreg

1996
Low molecular weight heparins: a valuable tool in the treatment of acute coronary syndromes.
    European heart journal, 1996, Volume: 17, Issue:10

    Topics: Angina, Unstable; Aspirin; Drug Administration Schedule; Drug Therapy, Combination; Heparin, Low-Mol

1996
[Clinical studies of the effectiveness of aspirin in the prevention of major cardio-cerebrovascular occurrences].
    Cardiologia (Rome, Italy), 1995, Volume: 40, Issue:12 Suppl 1

    Topics: Angina, Unstable; Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Humans; Myocardial I

1995
[The use of acetylsalicylic acid in IHD].
    Terapevticheskii arkhiv, 1996, Volume: 68, Issue:8

    Topics: Angina, Unstable; Aspirin; Coronary Vessels; Cyclooxygenase Inhibitors; Dose-Response Relationship,

1996
[Low molecular weight heparin in unstable angina].
    Archives des maladies du coeur et des vaisseaux, 1996, Volume: 89, Issue:11 Suppl

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Dalteparin; Dose-Response Relationship, Drug; Drug Therap

1996
Unmet therapeutic needs in the management of acute ischemia.
    The American journal of cardiology, 1997, Aug-18, Volume: 80, Issue:4A

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Coronary Artery Disease; Fibrinolytic Agents; Humans; Myo

1997
Platelet activation and inhibition in unstable coronary syndromes.
    The American journal of cardiology, 1997, Sep-04, Volume: 80, Issue:5A

    Topics: Angina, Unstable; Aspirin; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation

1997
[Current aspects of thrombolytic therapy in unstable angina pectoris].
    Zeitschrift fur Kardiologie, 1997, Volume: 86, Issue:11

    Topics: Angina, Unstable; Aspirin; Heparin, Low-Molecular-Weight; Humans; Myocardial Infarction; Platelet Gl

1997
New therapies for unstable angina and non-Q-wave myocardial infarction: recent clinical trials.
    American heart journal, 1998, Volume: 135, Issue:6 Pt 3 Su

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Clinical Trials as Topic; Hematologic Agents; Heparin; He

1998
Clinical potential of antithrombotic drugs in coronary syndromes.
    The American journal of cardiology, 1998, Sep-10, Volume: 82, Issue:5B

    Topics: Angina, Unstable; Aspirin; Coronary Thrombosis; Dose-Response Relationship, Drug; Drug Therapy, Comb

1998
[Antithrombotic agents in unstable angina. Review of clinical trials].
    Annales de cardiologie et d'angeiologie, 1998, Volume: 47, Issue:1

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Hirudin

1998
Treatment options in unstable angina: a clinical update.
    European heart journal, 1998, Volume: 19 Suppl K

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Coronary Thrombosis; Drug Therapy, Combination; Electroca

1998
Antithrombotic agents in coronary artery disease.
    Chest, 1998, Volume: 114, Issue:5 Suppl

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Coronary Disease; Coronary Thrombosis; Fibrinolytic Agent

1998
Antithrombotic therapy of unstable angina and non-Q-wave myocardial infarction.
    International journal of cardiology, 1999, Apr-10, Volume: 68 Suppl 1

    Topics: Abciximab; Angina, Unstable; Antibodies, Monoclonal; Anticoagulants; Aspirin; Fibrinolytic Agents; H

1999
[Conservative management in patients with acute coronary syndrome].
    Journal of cardiology, 1999, Volume: 33 Suppl 1

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Fibrinolytic Agents; Heparin; Hirudin Therapy; Hirudins;

1999
Low molecular weight heparins in the cardiac catheterization laboratory.
    Journal of thrombosis and thrombolysis, 1999, Volume: 7, Issue:3

    Topics: Abciximab; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants;

1999
Glycoprotein IIb/IIIa receptor inhibition in interventional cardiology.
    Journal of thrombosis and thrombolysis, 1999, Volume: 7, Issue:3

    Topics: Abciximab; Administration, Oral; Adult; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Anti

1999
"Traditional" medical therapy for unstable angina. How important? How to use?
    Cardiology clinics, 1999, Volume: 17, Issue:2

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Anticoagulants; Aspirin; Calcium Channel Blockers; He

1999
Management of high-risk subsets in unstable angina.
    Cardiology clinics, 1999, Volume: 17, Issue:2

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Atherectomy, Coronary; Calcium Channel Bl

1999
[Current therapy for unstable angina pectoris].
    Deutsche medizinische Wochenschrift (1946), 1999, Jun-11, Volume: 124, Issue:23

    Topics: Angina, Unstable; Anti-Bacterial Agents; Anticholesteremic Agents; Anticoagulants; Antithrombins; As

1999
Combination therapy for acute myocardial infarction: glycoprotein IIb/IIIa inhibitors plus thrombolysis.
    Clinical cardiology, 1999, Volume: 22, Issue:8 Suppl

    Topics: Angina, Unstable; Aspirin; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Myocardial Infarc

1999
Anticoagulants in acute coronary syndromes.
    The American journal of cardiology, 1999, Sep-02, Volume: 84, Issue:5A

    Topics: Acute Disease; Angina, Unstable; Anticoagulants; Aspirin; Clinical Trials as Topic; Coronary Disease

1999
Ticlopidine and clopidogrel.
    Circulation, 1999, Oct-12, Volume: 100, Issue:15

    Topics: Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Angina, Unstable; Aspirin; Bo

1999
[Angioplasty in unstable chest angina. Angioplasty in unstable angina].
    Archives des maladies du coeur et des vaisseaux, 1999, Volume: 92, Issue:11 Suppl

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Angioplasty, Balloon, Coronary; Anti-Inflammatory Age

1999
Unfractionated and low-molecular-weight heparins in acute coronary syndromes: current recommendations.
    Cleveland Clinic journal of medicine, 2000, Volume: 67, Issue:1

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Clinical Trials as Topic; Coronary Disease; Enoxaparin; F

2000
Long-term management--the way forward?
    Clinical cardiology, 2000, Volume: 23 Suppl 1

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Coronary Artery Disease; Dalteparin; Drug Therapy, Combin

2000
Targeting treatment for optimal outcome.
    Clinical cardiology, 2000, Volume: 23 Suppl 1

    Topics: Age Factors; Aged; Angina, Unstable; Anticoagulants; Aspirin; Biomarkers; Clinical Protocols; Daltep

2000
Aspirin.
    Circulation, 2000, Mar-14, Volume: 101, Issue:10

    Topics: Angina, Unstable; Aspirin; Cerebrovascular Disorders; Digestive System; Humans; Myocardial Infarctio

2000
[Aspirin and prevention of cardiovascular risk].
    La Revue de medecine interne, 2000, Volume: 21 Suppl 1

    Topics: Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents, Non-Ste

2000
Percutaneous revascularization for unstable angina in the elderly.
    Coronary artery disease, 2000, Volume: 11, Issue:4

    Topics: Abciximab; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagu

2000
Anti-thrombotic therapy for elderly patients with acute coronary syndromes.
    Coronary artery disease, 2000, Volume: 11, Issue:4

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Heparin; Heparin, Low-Molecular-Weight; Humans; Myocardia

2000
Oral platelet glycoprotein IIb/IIIa inhibition.
    Current cardiology reports, 2000, Volume: 2, Issue:5

    Topics: Alanine; Angina, Unstable; Aspirin; Benzamidines; Clinical Trials, Phase II as Topic; Clinical Trial

2000
Contemporary diagnosis and management of unstable angina.
    Mayo Clinic proceedings, 2000, Volume: 75, Issue:9

    Topics: Abciximab; Acute Disease; Algorithms; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies,

2000
Clinical trials of unfractionated heparin and low-molecular-weight heparin in addition to aspirin for the treatment of unstable angina pectoris: do the results apply to all patients?
    The American journal of cardiology, 2000, Nov-01, Volume: 86, Issue:9

    Topics: Adult; Aged; Analysis of Variance; Angina, Unstable; Aspirin; Chi-Square Distribution; Cohort Studie

2000
[Therapeutic inhibition of platelets in a acute coronary syndrome and in coronary intervention: mechanisms and clinical results].
    Zeitschrift fur Kardiologie, 2000, Volume: 89 Suppl 7

    Topics: Abciximab; Acute Disease; Adult; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary;

2000
[Low molecular weight heparin in the treatment of acute coronary syndromes without ST-segment elevation: unstable angina and non-Q-wave myocardial infarction].
    Medicina clinica, 2000, Nov-04, Volume: 115, Issue:15

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Clinical Trials as Topic; Confidence Intervals; Daltepari

2000
[Platelet-leukocyte interactions in coronary heart disease: pathophysiology, clinical relevance, pharmacological modulation].
    Journal des maladies vasculaires, 2000, Volume: 25, Issue:5

    Topics: Abciximab; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal

2000
Present treatment options for unstable angina and non-Q-wave myocardial infarction.
    QJM : monthly journal of the Association of Physicians, 2001, Volume: 94, Issue:1

    Topics: Algorithms; Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Coro

2001
Low-molecular-weight heparin and other antithrombotic agents in the setting of a fast-track revascularization in unstable coronary artery disease.
    Haemostasis, 2000, Volume: 30 Suppl 2

    Topics: Abciximab; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants;

2000
Low-molecular-weight heparin and other antithrombotic agents in the setting of a primarily medical treatment of unstable coronary artery disease.
    Haemostasis, 2000, Volume: 30 Suppl 2

    Topics: Acute Disease; Administration, Oral; Angina, Unstable; Anticoagulants; Aspirin; Clinical Trials as T

2000
Low-molecular-weight heparins in the management of unstable angina.
    Haemostasis, 2000, Volume: 30 Suppl 2

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Combined Modality Therapy; Double-Blind Method; Drug Admi

2000
[Acute coronary syndromes: an update. I. Pathogenesis and drug therapy].
    Herz, 2001, Volume: 26, Issue:2

    Topics: Acute Disease; Administration, Oral; Adrenergic beta-Antagonists; Angina, Unstable; Anticoagulants;

2001
Antithrombotic drugs for older subjects. Guidelines formulated jointly by the Italian Societies of Haemostasis and Thrombosis (SISET) and of Gerontology and Geriatrics (SIGG).
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2001, Volume: 11, Issue:1

    Topics: Aged; Angina, Unstable; Anticoagulants; Aspirin; Female; Fibrinolytic Agents; Heparin; Heparin, Low-

2001
Current guidelines for the management of unstable angina: a new diagnostic and management paradigm.
    Internal medicine journal, 2001, Volume: 31, Issue:2

    Topics: Adrenergic beta-Antagonists; Algorithms; Angina, Unstable; Anticoagulants; Aspirin; Biomarkers; Coro

2001
Management of acute coronary syndromes.
    American journal of respiratory and critical care medicine, 2001, Sep-15, Volume: 164, Issue:6

    Topics: Abciximab; Acute Disease; Adrenergic beta-Antagonists; Aged; Angina, Unstable; Angiotensin-Convertin

2001
Platelet glycoprotein IIb/IIIa blockers for percutaneous coronary revascularization, and unstable angina and non-ST-segment elevation myocardial infarction.
    The Cochrane database of systematic reviews, 2001, Issue:4

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Fibrinolytic Agents; Heparin; Humans; Myo

2001
New approaches to the pharmacological treatment of angina.
    Current opinion in pharmacology, 2001, Volume: 1, Issue:2

    Topics: Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inh

2001
Combination therapy with clopidogrel and aspirin: can the CURE results be extrapolated to cerebrovascula patients?
    Stroke, 2001, Dec-01, Volume: 32, Issue:12

    Topics: Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans;

2001
Unstable angina and non-ST-segment elevation myocardial infarction: perspectives on combination therapy.
    Texas Heart Institute journal, 2001, Volume: 28, Issue:4

    Topics: Adenosine Diphosphate; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Dr

2001
From CURE to MATCH: ADP receptor antagonists as the treatment of choice for high-risk atherothrombotic patients.
    Cerebrovascular diseases (Basel, Switzerland), 2002, Volume: 13 Suppl 1

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Drug Therapy, Combination; Heparin; Humans; Intracranial Art

2002
Persistence of the prothrombotic state after acute coronary syndromes: implications for treatment.
    American heart journal, 2002, Volume: 143, Issue:2

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Coronary Thrombosis; Heparin, Low-Molecular-Weight; Humans;

2002
[Modern therapy in acute coronary syndrome].
    Medizinische Klinik (Munich, Germany : 1983), 2002, Apr-15, Volume: 97, Issue:4

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Di

2002
Critical pathways for management of patients with acute coronary syndromes: an assessment by the National Heart Attack Alert Program.
    American heart journal, 2002, Volume: 143, Issue:5

    Topics: Acute Disease; Angina, Unstable; Anticoagulants; Aspirin; Clinical Trials as Topic; Coronary Care Un

2002
Antiplatelet treatment in unstable angina: aspirin, clopidogrel, glycoprotein IIb/IIIa antagonist, or all three?
    Heart (British Cardiac Society), 2002, Volume: 88, Issue:1

    Topics: Administration, Oral; Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Costs;

2002
[Acetylsalicylic acid in unstable angina, after coronary revascularization and in prevention of cardiac thromboembolism].
    Zeitschrift fur Kardiologie, 1992, Volume: 81 Suppl 4

    Topics: Angina, Unstable; Aspirin; Coronary Artery Bypass; Graft Occlusion, Vascular; Heart Valve Prosthesis

1992
[Prostaglandins and ischemic cardiopathy].
    Giornale italiano di cardiologia, 1992, Volume: 22, Issue:12

    Topics: Angina, Unstable; Aspirin; Coronary Thrombosis; Humans; Myocardial Ischemia; Platelet Activation; Pr

1992
[Coronary insufficiency and heparin].
    Arquivos brasileiros de cardiologia, 1992, Volume: 58, Issue:1

    Topics: Angina, Unstable; Aspirin; Coronary Thrombosis; Drug Therapy, Combination; Heparin; Humans; Myocardi

1992
Aspirin for the prevention of vascular death in women.
    The Annals of pharmacotherapy, 1992, Volume: 26, Issue:12

    Topics: Angina, Unstable; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Female; Humans; Risk

1992
[Angioplasty in unstable angina].
    Cardiologia (Rome, Italy), 1992, Volume: 37, Issue:2

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clinical Trials as Topic; Combined Modali

1992
[Coronary insufficiency and heparin].
    Arquivos brasileiros de cardiologia, 1991, Volume: 57, Issue:2

    Topics: Angina, Unstable; Aspirin; Coronary Thrombosis; Drug Therapy, Combination; Fibrinolytic Agents; Hepa

1991
Unstable angina: pathophysiology and drug therapy.
    European journal of clinical pharmacology, 1990, Volume: 38 Suppl 1

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Anticoagulants; Aspirin; Calcium Cha

1990
[Drug therapy of acute coronary syndrome. Summary of a hearing arranged by the Norwegian Cardiologic Society and the Institute of pharmacotherapy].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1990, Sep-10, Volume: 110, Issue:21

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Angiotensin-Converting Enzyme Inhibitors; Aspirin; He

1990
Anti-thrombotic drugs in the treatment of coronary heart disease: the present situation with aspirin.
    Zeitschrift fur Kardiologie, 1990, Volume: 79 Suppl 3

    Topics: Angina, Unstable; Aspirin; Combined Modality Therapy; Coronary Disease; Coronary Thrombosis; Humans;

1990
Pathophysiological role of thromboxane A2 and pharmacological approaches to its inhibition.
    Zeitschrift fur Kardiologie, 1990, Volume: 79 Suppl 3

    Topics: Angina, Unstable; Animals; Aspirin; Humans; Myocardial Infarction; Prostaglandin Endoperoxides, Synt

1990
Unstable angina and thrombolysis.
    Chest, 1990, Volume: 97, Issue:4 Suppl

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Coronary Thrombosis; Heparin; Humans; Thrombolytic Thera

1990
Use of desmopressin in the management of aspirin-related and intractable haemorrhage after cardiopulmonary bypass.
    The Australian and New Zealand journal of surgery, 1990, Volume: 60, Issue:2

    Topics: Adult; Aged; Angina, Unstable; Aspirin; Blood Coagulation Tests; Cardiopulmonary Bypass; Deamino Arg

1990
Aspirin and thrombolytic therapy in the management of acute myocardial infarction.
    Australian family physician, 1990, Volume: 19, Issue:7

    Topics: Angina, Unstable; Aspirin; Fibrinolytic Agents; Humans; Myocardial Infarction; Thrombolytic Therapy

1990
[Aspirin in ischemic heart disease].
    Vutreshni bolesti, 1990, Volume: 29, Issue:4

    Topics: Angina, Unstable; Aspirin; Coronary Disease; Humans; Myocardial Infarction; Platelet Aggregation; Po

1990
The Jeremiah Metzger lecture. Participation of eicosanoids in the syndromes of myocardial ischemia.
    Transactions of the American Clinical and Climatological Association, 1990, Volume: 101

    Topics: Angina, Unstable; Arteriosclerosis; Aspirin; Coronary Disease; Eicosanoids; Humans; Myocardial Infar

1990
Pathophysiology and management of unstable angina.
    Clinical cardiology, 1989, Volume: 12, Issue:7

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Aspirin; Electrocardiography; Hepari

1989
Restoration of flow in acute coronary obstructive syndromes: consequences of different management strategies.
    The Canadian journal of cardiology, 1989, Volume: 5, Issue:3

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Clinical Trials as Topic; Coronary Circulation; Humans;

1989
Current perspectives in the antiplatelet therapy of thrombotic disorders.
    Seminars in thrombosis and hemostasis, 1989, Volume: 15, Issue:2

    Topics: Angina, Unstable; Aspirin; Clinical Trials as Topic; Coronary Disease; Coronary Thrombosis; Humans;

1989
[Platelet antiaggregants and coronary pathology].
    La Revue du praticien, 1989, Nov-01, Volume: 39, Issue:25

    Topics: Angina, Unstable; Aspirin; Coronary Disease; Humans; Myocardial Infarction; Recurrence

1989
Management of unstable angina soon after myocardial infarction.
    British journal of hospital medicine, 1988, Volume: 39, Issue:5

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon; Anticoagulants

1988
[The state of thrombolytic therapy in acute myocardial infarct].
    Wiener klinische Wochenschrift, 1985, Sep-13, Volume: 97, Issue:17

    Topics: Angina, Unstable; Angioplasty, Balloon; Aspirin; Coronary Artery Bypass; Coronary Vessels; Creatine

1985
Overview of results of randomized clinical trials in heart disease. II. Unstable angina, heart failure, primary prevention with aspirin, and risk factor modification.
    JAMA, 1988, Oct-21, Volume: 260, Issue:15

    Topics: Angina, Unstable; Aspirin; Blood Pressure; Cholesterol; Exercise; Heart Diseases; Heart Failure; Hum

1988
Which role for antiplatelet and anticoagulant drugs in unstable angina pectoris?
    Cardiovascular drugs and therapy, 1988, Volume: 2, Issue:1

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Humans; Platelet Aggregation Inhibitors

1988
Thrombosis in unstable angina: angiographic aspects.
    Cardiovascular clinics, 1987, Volume: 18, Issue:1

    Topics: Angina Pectoris; Angina, Unstable; Angiography; Arteries; Aspirin; Coronary Circulation; Coronary Di

1987
Clinical trials of antiplatelet drug therapy in acute myocardial infarction, unstable angina, and aortocoronary bypass surgery.
    Cardiovascular clinics, 1987, Volume: 18, Issue:1

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Blood Platelets; Clinical Trials as Topic; Coronary Arte

1987
[Unstable angina pectoris, acute myocardial infarct, sudden heart death. Patho-anatomy and pathophysiology].
    Ugeskrift for laeger, 1987, Nov-02, Volume: 149, Issue:45

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Calcium Channel Blockers; Coronary Angiography; Coronary

1987
Antithrombotic agents in coronary artery disease.
    Chest, 1986, Volume: 89, Issue:2 Suppl

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Blood Platelets; Clinical Trials as Topic; Coronary Disea

1986
Effectiveness of anticoagulants.
    Seminars in thrombosis and hemostasis, 1986, Volume: 12, Issue:1

    Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Angina, Unstable; Anticoagulants; Aspirin; Blood

1986
Aspirin for the prevention of coronary thrombosis: current facts and perspectives.
    European heart journal, 1986, Volume: 7, Issue:6

    Topics: Angina, Unstable; Animals; Aspirin; Clinical Trials as Topic; Coronary Artery Bypass; Coronary Disea

1986
[Anti-aggregating agents: for which patients?].
    Annales de cardiologie et d'angeiologie, 1986, Volume: 35, Issue:10

    Topics: Angina, Unstable; Aspirin; Coronary Artery Bypass; Heart Valve Prosthesis; Humans; Myocardial Infarc

1986
[Controversy on platelet-inhibiting drugs].
    Schweizerische medizinische Wochenschrift, 1985, May-18, Volume: 115, Issue:20

    Topics: Angina, Unstable; Aspirin; Blood Platelets; Cerebrovascular Disorders; Clinical Trials as Topic; Cor

1985

Trials

153 trials available for aspirin and Angina, Unstable

ArticleYear
[The effect of clopidogrel and aspigrel on myocardial ischemia in patients with unstable angina pectoris].
    Likars'ka sprava, 2013, Issue:2

    Topics: Aged; Angina, Unstable; Aspirin; Clopidogrel; Drug Combinations; Drug Therapy, Combination; Humans;

2013
Association Between Very Low Levels of High-Density Lipoprotein Cholesterol and Long-term Outcomes of Patients With Acute Coronary Syndrome Treated Without Revascularization: Insights From the TRILOGY ACS Trial.
    Clinical cardiology, 2016, Volume: 39, Issue:6

    Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Biomarkers; Cholesterol, HDL; Clopidogrel;

2016
Sulfotanshinone Sodium Injection could decrease fibrinogen level and improve clinical outcomes in patients with unstable angina pectoris.
    International journal of cardiology, 2009, Jun-26, Volume: 135, Issue:2

    Topics: Abietanes; Angina, Unstable; Anticoagulants; Aspirin; Dimerization; Drugs, Chinese Herbal; Female; F

2009
5-year clinical outcomes in the ICTUS (Invasive versus Conservative Treatment in Unstable coronary Syndromes) trial a randomized comparison of an early invasive versus selective invasive management in patients with non-ST-segment elevation acute coronary
    Journal of the American College of Cardiology, 2010, Mar-02, Volume: 55, Issue:9

    Topics: Abciximab; Acute Coronary Syndrome; Adolescent; Adult; Aged; Aged, 80 and over; Angina, Unstable; An

2010
Dose-related effect of aspirin on laboratory-defined platelet aggregation and clinical outcome after coronary stenting.
    Cardiovascular therapeutics, 2010, Volume: 28, Issue:3

    Topics: Adenosine Diphosphate; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Chi-Square D

2010
Apixaban with antiplatelet therapy after acute coronary syndrome.
    The New England journal of medicine, 2011, Aug-25, Volume: 365, Issue:8

    Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Double-Blind Method; Drug Therapy, Combina

2011
Apixaban with antiplatelet therapy after acute coronary syndrome.
    The New England journal of medicine, 2011, Aug-25, Volume: 365, Issue:8

    Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Double-Blind Method; Drug Therapy, Combina

2011
Apixaban with antiplatelet therapy after acute coronary syndrome.
    The New England journal of medicine, 2011, Aug-25, Volume: 365, Issue:8

    Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Double-Blind Method; Drug Therapy, Combina

2011
Apixaban with antiplatelet therapy after acute coronary syndrome.
    The New England journal of medicine, 2011, Aug-25, Volume: 365, Issue:8

    Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Double-Blind Method; Drug Therapy, Combina

2011
[Changes in coagulation and fibrinolysis in the patients with coronary heart disease in acute period and effect of drug intervention].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2012, Volume: 24, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Blood Coagulation; Case-Control Studies;

2012
Prasugrel versus clopidogrel for acute coronary syndromes without revascularization.
    The New England journal of medicine, 2012, Oct-04, Volume: 367, Issue:14

    Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Cardiovascular Diseases; Clopidogrel; Doub

2012
Platelet function during extended prasugrel and clopidogrel therapy for patients with ACS treated without revascularization: the TRILOGY ACS platelet function substudy.
    JAMA, 2012, Nov-07, Volume: 308, Issue:17

    Topics: Acute Coronary Syndrome; Age Factors; Aged; Angina, Unstable; Aspirin; Body Weight; Clopidogrel; Fem

2012
Platelet function during extended prasugrel and clopidogrel therapy for patients with ACS treated without revascularization: the TRILOGY ACS platelet function substudy.
    JAMA, 2012, Nov-07, Volume: 308, Issue:17

    Topics: Acute Coronary Syndrome; Age Factors; Aged; Angina, Unstable; Aspirin; Body Weight; Clopidogrel; Fem

2012
Platelet function during extended prasugrel and clopidogrel therapy for patients with ACS treated without revascularization: the TRILOGY ACS platelet function substudy.
    JAMA, 2012, Nov-07, Volume: 308, Issue:17

    Topics: Acute Coronary Syndrome; Age Factors; Aged; Angina, Unstable; Aspirin; Body Weight; Clopidogrel; Fem

2012
Platelet function during extended prasugrel and clopidogrel therapy for patients with ACS treated without revascularization: the TRILOGY ACS platelet function substudy.
    JAMA, 2012, Nov-07, Volume: 308, Issue:17

    Topics: Acute Coronary Syndrome; Age Factors; Aged; Angina, Unstable; Aspirin; Body Weight; Clopidogrel; Fem

2012
Modulation of aspirin-insensitive eicosanoid biosynthesis by 6-methylprednisolone in unstable angina.
    Circulation, 2003, Jan-07, Volume: 107, Issue:1

    Topics: Adult; Angina, Unstable; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Double-Blind Method; E

2003
Early and late effects of clopidogrel in patients with acute coronary syndromes.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Acute Disease; Angina, Unstable; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combinatio

2003
The Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) study: to what extent should the results be generalizable?
    American heart journal, 2003, Volume: 145, Issue:4

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Coronary Disease; Double-Blind Method; Female; Heart Failure

2003
Interleukin-7-mediated inflammation in unstable angina: possible role of chemokines and platelets.
    Circulation, 2003, Jun-03, Volume: 107, Issue:21

    Topics: Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cells, Cultured

2003
Parameters of the tissue factor pathway with coumadin/dipyridamole versus ticlopidine as adjunct antithrombotic-drug regimen in coronary artery stenting.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2003, Volume: 14, Issue:4

    Topics: Adult; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; C

2003
Effects of glycoprotein IIb/IIIa inhibition on clinical stabilization parameters in patients with unstable angina and non-Q-wave myocardial infarction.
    Heart and vessels, 2003, Volume: 18, Issue:3

    Topics: Adult; Aged; Angina, Unstable; Aspirin; Female; Fibrinolytic Agents; Heart Conduction System; Hepari

2003
Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study.
    Circulation, 2003, Oct-07, Volume: 108, Issue:14

    Topics: Acute Disease; Angina, Unstable; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Double-Blin

2003
[Non ST elevation acute coronary syndrome. Some characteristics of coagulation and von Willebrand factor during short term use of ticlopidine or clopidogrel].
    Kardiologiia, 2003, Volume: 43, Issue:10

    Topics: Acute Disease; Adult; Angina, Unstable; Anticoagulants; Aspirin; Blood Coagulation; Clopidogrel; Dat

2003
Evaluating the benefits of glycoprotein IIb/IIIa inhibitors in heart failure at baseline in acute coronary syndromes.
    American heart journal, 2004, Volume: 147, Issue:1

    Topics: Aged; Angina, Unstable; Aspirin; Chi-Square Distribution; Double-Blind Method; Eptifibatide; Female;

2004
Prospective evaluation of the relationship between platelet-leukocyte conjugate formation and recurrent myocardial ischemia in patients with acute coronary syndromes.
    Platelets, 2004, Volume: 15, Issue:1

    Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Aged; Angina, Unstable; Arachidonic Acid; Aspiri

2004
Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) Trial.
    Circulation, 2004, Sep-07, Volume: 110, Issue:10

    Topics: Acute Disease; Adult; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel;

2004
Incidence and characteristics of stroke during 90-day follow-up in patients stabilized after an acute coronary syndrome.
    American heart journal, 2004, Volume: 148, Issue:3

    Topics: Acute Disease; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Coronary Artery Bypa

2004
Comparison of two strategies for the management of antiplatelet therapy during urgent surgery.
    The Annals of thoracic surgery, 2005, Volume: 80, Issue:1

    Topics: Aged; Angina, Unstable; Aprotinin; Aspirin; Clopidogrel; Coronary Artery Bypass; Female; Hemostatics

2005
Prospective randomized comparison of early and late results of a carbonized stent versus a high-grade stainless steel stent of identical design: the PREVENT Trial [corrected].
    American heart journal, 2005, Volume: 149, Issue:4

    Topics: Adult; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Biocompatibl

2005
Coronary stent restenosis in patients treated with cilostazol.
    Circulation, 2005, Nov-01, Volume: 112, Issue:18

    Topics: Aged; Angina, Unstable; Aspirin; Cilostazol; Coronary Restenosis; Double-Blind Method; Female; Human

2005
Platelet hyper-function in acute coronary syndromes.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2005, Volume: 16, Issue:8

    Topics: Administration, Oral; Angina, Unstable; Aspirin; Bleeding Time; Female; Humans; Male; Myocardial Inf

2005
Prevalence and management of hypertension in acute coronary syndrome patients varies by sex: observations from the Sibrafiban versus aspirin to Yield Maximum Protection from ischemic Heart events postacute cOroNary sYndromes (SYMPHONY) randomized clinical
    American heart journal, 2005, Volume: 150, Issue:6

    Topics: Acute Disease; Aged; Angina, Unstable; Aspirin; Chemistry, Pharmaceutical; Coronary Disease; Female;

2005
Risk factors for stroke after acute coronary syndromes in the Orbofiban in Patients with Unstable Coronary Syndromes--Thrombolysis In Myocardial Infarction (OPUS-TIMI) 16 study.
    American heart journal, 2006, Volume: 151, Issue:2

    Topics: Aged; Alanine; Angina, Unstable; Aspirin; Cerebral Hemorrhage; Female; Fibrinolytic Agents; Follow-U

2006
Randomized evaluation of the efficacy of enoxaparin versus unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes receiving the glycoprotein IIb/IIIa inhibitor eptifibatide. Long-term results of the Integrilin
    American heart journal, 2006, Volume: 151, Issue:2

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Enoxaparin; Eptifibatide; Female; Heparin; Humans; Male;

2006
Effect of aspirin plus clopidogrel on inflammatory markers in patients with non-ST-segment elevation acute coronary syndrome.
    Chinese medical journal, 2006, Jan-05, Volume: 119, Issue:1

    Topics: Adult; Aged; Angina, Unstable; Aspirin; C-Reactive Protein; Clopidogrel; Drug Therapy, Combination;

2006
Randomized comparison of the effects of ASA plus clopidogrel versus ASA alone on early platelet activation in acute coronary syndromes with elevated high-sensitivity C-reactive protein and soluble CD40 ligand levels.
    Clinical therapeutics, 2006, Volume: 28, Issue:6

    Topics: Acute Disease; Aged; Angina, Unstable; Aspirin; C-Reactive Protein; CD40 Ligand; Clopidogrel; Dose-R

2006
Erythrocyte deformability and white blood cell count are associated with aspirin resistance in high-risk vascular patients.
    Clinical hemorheology and microcirculation, 2006, Volume: 35, Issue:1-2

    Topics: Aged; Angina, Unstable; Aspirin; Bleeding Time; Blood Viscosity; Clopidogrel; Drug Resistance; Eryth

2006
Drug-induced thrombocytopenia and thrombosis: evidence from patients receiving an oral glycoprotein IIb/IIIa inhibitor in the Orbofiban in Patients with Unstable coronary Syndromes- (OPUS-TIMI 16) trial.
    Journal of thrombosis and thrombolysis, 2006, Volume: 22, Issue:2

    Topics: Aged; Alanine; Angina, Unstable; Aspirin; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged;

2006
The role of aspirin resistance on outcome in patients with acute coronary syndrome and the effect of clopidogrel therapy in the prevention of major cardiovascular events.
    Journal of thrombosis and thrombolysis, 2006, Volume: 22, Issue:2

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Follow-Up

2006
Long-term outcome after an early invasive versus selective invasive treatment strategy in patients with non-ST-elevation acute coronary syndrome and elevated cardiac troponin T (the ICTUS trial): a follow-up study.
    Lancet (London, England), 2007, Mar-10, Volume: 369, Issue:9564

    Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Aspirin; Biomarkers; Cardiac Catheterization; C

2007
Safety of sirolimus-eluting stenting and its effect on restenosis in patients with unstable angina pectoris (a SIRIUS substudy).
    The American journal of cardiology, 2007, Apr-15, Volume: 99, Issue:8

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Corona

2007
Effects of Quyu xiaoban capsules on clinical outcomes and platelet activation and aggregation in patients with unstable angina pectoris.
    Journal of alternative and complementary medicine (New York, N.Y.), 2007, Volume: 13, Issue:3

    Topics: Angina, Unstable; Aspirin; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Comb

2007
Effects of Quyu Xiaoban capsules on clinical outcomes and platelet activation and aggregation in patients with unstable angina pectoris.
    Journal of alternative and complementary medicine (New York, N.Y.), 2007, Volume: 13, Issue:5

    Topics: Adult; Angina, Unstable; Aspirin; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therap

2007
Use of evidence-based medicine for acute coronary syndromes in the elderly and very elderly: insights from the Sibrafiban vs aspirin to Yield Maximum Protection from ischemic Heart events postacute cOroNary sYndromes trials.
    American heart journal, 2007, Volume: 154, Issue:2

    Topics: Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Cardiovascular Agents; Evidence-Based Medicine;

2007
Timing of death and myocardial infarction in patients with non-ST elevation acute coronary syndromes: insights from randomized clinical trials.
    Journal of interventional cardiology, 2007, Volume: 20, Issue:5

    Topics: Acute Disease; Aged; Angina, Unstable; Aspirin; Female; Hirudin Therapy; Hirudins; Humans; Male; Mid

2007
Cost-effectiveness of clopidogrel in acute coronary syndromes in Canada: a long-term analysis based on the CURE trial.
    The Canadian journal of cardiology, 2007, Volume: 23, Issue:13

    Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Canada; Cl

2007
[Unstable angina: efficacy and tolerability of therapy with aspirin and aspirin combined with ticlopidine].
    Kardiologiia, 2007, Volume: 47, Issue:5

    Topics: Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Progression; Drug Therap

2007
Early and late benefits of prasugrel in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a TRITON-TIMI 38 (TRial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet InhibitioN with Prasugrel-Thrombolys
    Journal of the American College of Cardiology, 2008, May-27, Volume: 51, Issue:21

    Topics: Acute Coronary Syndrome; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Com

2008
Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of a Veterans Administration Cooperative Study.
    The New England journal of medicine, 1983, Aug-18, Volume: 309, Issue:7

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Aspirin; Clinical Trials as Topic; Death, Sudden; Dou

1983
Mechanisms contributing to precipitation of unstable angina and acute myocardial infarction: implications regarding therapy.
    The American journal of cardiology, 1984, Dec-01, Volume: 54, Issue:10

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon; Animals; Antic

1984
The diagnostic and prognostic importance of ambulatory ST recording compared to a predischarge exercise test after an episode of unstable angina or non-Q wave myocardial infarction.
    European heart journal, 1995, Volume: 16, Issue:7

    Topics: Administration, Oral; Adult; Aged; Ambulatory Care; Angina, Unstable; Aspirin; Coronary Disease; Dos

1995
Low molecular weight heparin versus regular heparin or aspirin in the treatment of unstable angina and silent ischemia.
    Journal of the American College of Cardiology, 1995, Volume: 26, Issue:2

    Topics: Adult; Aged; Angina, Unstable; Aspirin; Chi-Square Distribution; Drug Therapy, Combination; Female;

1995
Hirulog in the treatment of unstable angina. Results of the Thrombin Inhibition in Myocardial Ischemia (TIMI) 7 trial.
    Circulation, 1995, Aug-15, Volume: 92, Issue:4

    Topics: Adult; Aged; Angina, Unstable; Aspirin; Coronary Angiography; Dose-Response Relationship, Drug; Doub

1995
Randomised comparison of subcutaneous heparin, intravenous heparin, and aspirin in unstable angina. Studio Epoorine Sottocutanea nell'Angina Instobile (SESAIR) Refrattorie Group.
    Lancet (London, England), 1995, May-13, Volume: 345, Issue:8959

    Topics: Angina, Unstable; Aspirin; Female; Heparin; Humans; Infusions, Intravenous; Injections, Subcutaneous

1995
Heparin and aspirin in unstable angina: insufficient sample size may lead to erroneous conclusions.
    Journal of the American College of Cardiology, 1995, Volume: 25, Issue:2

    Topics: Angina, Unstable; Aspirin; Drug Therapy, Combination; Heparin; Humans; Myocardial Ischemia; Sample S

1995
[Adverse effects of combined use of acenocoumarol and acetylsalicylic acid after myocardial infarct and unstable angina].
    Orvosi hetilap, 1995, Jan-22, Volume: 136, Issue:4

    Topics: Acenocoumarol; Angina, Unstable; Aspirin; Drug Synergism; Drug Therapy, Combination; Female; Hemorrh

1995
Prospective comparison of unstable angina versus non-Q wave myocardial infarction during antithrombotic therapy. Antithrombotic Therapy in Acute Coronary Syndromes Research Group.
    Journal of the American College of Cardiology, 1993, Nov-01, Volume: 22, Issue:5

    Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Aspirin; Calcium Channel Blockers; Drug Therapy

1993
[Unstable angina: effect of aspirin and heparin on treatment outcome in hospital patients (a double-blind, placebo-controlled study)].
    Kardiologiia, 1993, Volume: 33, Issue:5

    Topics: Administration, Oral; Adult; Aged; Angina, Unstable; Aspirin; Double-Blind Method; Female; Follow-Up

1993
[Ticlopidine and aspirin in the treatment of unstable angina: comparative evaluation of their effect of anti-aggregation and platelet membranes].
    Kardiologiia, 1993, Volume: 33, Issue:5

    Topics: Adult; Aged; Angina, Unstable; Anti-Arrhythmia Agents; Aspirin; Cholesterol; Heparin; Humans; Male;

1993
Prospective evaluation of a prostacyclin-sparing aspirin formulation and heparin/warfarin in aspirin users with unstable angina or non-Q wave myocardial infarction at rest. The Antithrombotic Therapy in Acute Coronary Syndromes Research Group.
    European heart journal, 1994, Volume: 15, Issue:9

    Topics: Adult; Angina, Unstable; Aspirin; Delayed-Action Preparations; Drug Therapy, Combination; Epoprosten

1994
Comparison of the effect of heparin and aspirin versus aspirin alone on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina.
    Journal of the American College of Cardiology, 1994, Volume: 24, Issue:1

    Topics: Adult; Aged; Angina, Unstable; Aspirin; Chi-Square Distribution; Diltiazem; Drug Therapy, Combinatio

1994
Aspirin versus heparin in the acute phase of unstable angina.
    Circulation, 1994, Volume: 90, Issue:2

    Topics: Angina, Unstable; Aspirin; Heparin; Humans; Linear Models; Logistic Models; Myocardial Infarction

1994
[Unstable angina: tissue-type plasminogen activator inhibitor and other hemostatic factors in aspirin and intravenous heparin administration].
    Kardiologiia, 1993, Volume: 33, Issue:8

    Topics: Administration, Oral; Angina, Unstable; Aspirin; Double-Blind Method; Female; Hemostasis; Heparin; H

1993
The role of extraplatelet thromboxane A2 in unstable angina investigated with a dual thromboxane A2 inhibitor: importance of activated monocytes.
    Coronary artery disease, 1994, Volume: 5, Issue:2

    Topics: Aged; Angina Pectoris; Angina, Unstable; Aspirin; Double-Blind Method; Female; Follow-Up Studies; Hu

1994
Aspirin versus heparin to prevent myocardial infarction during the acute phase of unstable angina.
    Circulation, 1993, Volume: 88, Issue:5 Pt 1

    Topics: Acute Disease; Angina, Unstable; Aspirin; Double-Blind Method; Drug Therapy, Combination; Factor Ana

1993
Combination antithrombotic therapy in unstable rest angina and non-Q-wave infarction in nonprior aspirin users. Primary end points analysis from the ATACS trial. Antithrombotic Therapy in Acute Coronary Syndromes Research Group.
    Circulation, 1994, Volume: 89, Issue:1

    Topics: Angina, Unstable; Aspirin; Drug Therapy, Combination; Electrocardiography; Female; Fibrinolytic Agen

1994
Risk stratification by early exercise testing after an episode of unstable coronary artery disease. The RISC Study Group.
    International journal of cardiology, 1993, Volume: 39, Issue:2

    Topics: Aged; Angina, Unstable; Aspirin; Coronary Disease; Electrocardiography; Exercise Test; Hemodynamics;

1993
Antiplatelet therapy--Part I.
    The Western journal of medicine, 1993, Volume: 158, Issue:4

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Cardiovascular Diseases; Coronary Artery Bypass; Coronar

1993
[Diltiazem versus intravenous nitroglycerin in the treatment of unstable angina pectoris. A randomized study].
    Revista medica de Chile, 1995, Volume: 123, Issue:7

    Topics: Aged; Analysis of Variance; Angina, Unstable; Anticoagulants; Aspirin; Blood Pressure; Cardiovascula

1995
Low-molecular-weight heparin during instability in coronary artery disease, Fragmin during Instability in Coronary Artery Disease (FRISC) study group.
    Lancet (London, England), 1996, Mar-02, Volume: 347, Issue:9001

    Topics: Adult; Aged; Aged, 80 and over; Angina, Unstable; Anticoagulants; Aspirin; Coronary Disease; Daltepa

1996
Early continuous ST segment monitoring in unstable angina: prognostic value additional to the clinical characteristics and the admission electrocardiogram.
    Heart (British Cardiac Society), 1996, Volume: 75, Issue:3

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina, Unstable; Aspirin; Electrocardiography; Electrocar

1996
Antiplatelet therapy in therapy-resistant unstable angina. A pilot study with REO PRO (c7E3).
    European heart journal, 1995, Volume: 16 Suppl L

    Topics: Abciximab; Adult; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; As

1995
Effects of integrelin, a platelet glycoprotein IIb/IIIa receptor antagonist, in unstable angina. A randomized multicenter trial.
    Circulation, 1996, Nov-01, Volume: 94, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Angina, Unstable; Anticoagulants; Aspirin; Bleeding Time; Dose-Respo

1996
Refining the treatment of women with unstable angina--a randomized, double-blind, comparative safety and efficacy evaluation of Integrelin versus aspirin in the management of unstable angina.
    Clinical cardiology, 1996, Volume: 19, Issue:11

    Topics: Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Double-Blind Method; Electrocardiography, Ambula

1996
Comparison of heparin therapy for < or = 48 hours to > 48 hours in unstable angina pectoris.
    The American journal of cardiology, 1997, Feb-01, Volume: 79, Issue:3

    Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Case-Control Studies; Coronary Angi

1997
Hemorrhagic events during therapy with recombinant tissue plasminogen activator, heparin, and aspirin for unstable angina (Thrombolysis in Myocardial Ischemia, phase IIIB trial).
    The American journal of cardiology, 1997, Feb-15, Volume: 79, Issue:4

    Topics: Aged; Angina, Unstable; Anticoagulants; Aspirin; Hemorrhage; Heparin; Humans; Plasminogen Activators

1997
Pathophysiology of transient myocardial ischemia in acute coronary syndromes. Characterization by continuous ST-segment monitoring.
    Circulation, 1997, Mar-04, Volume: 95, Issue:5

    Topics: Acute Disease; Angina, Unstable; Anticoagulants; Aspirin; Circadian Rhythm; Drug Therapy, Combinatio

1997
[Secondary prevention in chronic coronary heart disease].
    Schweizerische medizinische Wochenschrift, 1997, Feb-15, Volume: 127, Issue:7

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angina, Unstable; Angiotensin-Convertin

1997
Comparison of low-molecular-weight heparin with unfractionated heparin acutely and with placebo for 6 weeks in the management of unstable coronary artery disease. Fragmin in unstable coronary artery disease study (FRIC)
    Circulation, 1997, Jul-01, Volume: 96, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Angina, Unstable; Anticoagulants; Aspirin; Blood Coagulation Tests;

1997
First chronic platelet glycoprotein IIb/IIIa integrin blockade. A randomized, placebo-controlled pilot study of xemilofiban in unstable angina with percutaneous coronary interventions.
    Circulation, 1997, Jul-01, Volume: 96, Issue:1

    Topics: Adult; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Benzamidines; Coronary Arter

1997
Progression of the culprit lesion in unstable coronary artery disease with warfarin and aspirin versus aspirin alone: preliminary study.
    Journal of the American College of Cardiology, 1997, Volume: 30, Issue:2

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Coronary Angiography; Coronary Vessels; Double-Blind Meth

1997
A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events Study Group.
    The New England journal of medicine, 1997, Aug-14, Volume: 337, Issue:7

    Topics: Aged; Angina, Unstable; Aspirin; Double-Blind Method; Drug Therapy, Combination; Enoxaparin; Female;

1997
A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events Study Group.
    The New England journal of medicine, 1997, Aug-14, Volume: 337, Issue:7

    Topics: Aged; Angina, Unstable; Aspirin; Double-Blind Method; Drug Therapy, Combination; Enoxaparin; Female;

1997
A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events Study Group.
    The New England journal of medicine, 1997, Aug-14, Volume: 337, Issue:7

    Topics: Aged; Angina, Unstable; Aspirin; Double-Blind Method; Drug Therapy, Combination; Enoxaparin; Female;

1997
A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events Study Group.
    The New England journal of medicine, 1997, Aug-14, Volume: 337, Issue:7

    Topics: Aged; Angina, Unstable; Aspirin; Double-Blind Method; Drug Therapy, Combination; Enoxaparin; Female;

1997
Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina.
    Circulation, 1997, Aug-19, Volume: 96, Issue:4

    Topics: Aged; Angina, Unstable; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cy

1997
Low-molecular-weight heparin (Fragmin) during instability in coronary artery disease (FRISC). FRISC Study Group.
    The American journal of cardiology, 1997, Sep-04, Volume: 80, Issue:5A

    Topics: Adult; Aged; Aged, 80 and over; Angina, Unstable; Anticoagulants; Aspirin; Dalteparin; Double-Blind

1997
[Intracoronary dipyridamole reduces the incidence of acute coronary vessel occlusion in percutaneous transluminal coronary angioplasty--a prospective randomized study].
    Zeitschrift fur Kardiologie, 1997, Volume: 86, Issue:12

    Topics: Adult; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Coronary Artery Bypass; Coro

1997
[Clinical safety using the thrombocyte aggregation inhibitor c7E3 in interventional cardiology in 520 patients].
    Zeitschrift fur Kardiologie, 1997, Volume: 86, Issue:12

    Topics: Abciximab; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Angina, Unstable

1997
Effects of prior aspirin and anti-ischemic therapy on outcome of patients with unstable angina. TIMI 7 Investigators. Thrombin Inhibition in Myocardial Ischemia.
    The American journal of cardiology, 1998, Mar-15, Volume: 81, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina, Unstable; Aspirin; Calcium Channel Blockers; Elect

1998
Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction.
    The New England journal of medicine, 1998, 05-21, Volume: 338, Issue:21

    Topics: Aged; Angina, Unstable; Aspirin; Double-Blind Method; Drug Therapy, Combination; Female; Fibrinolyti

1998
A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina.
    The New England journal of medicine, 1998, 05-21, Volume: 338, Issue:21

    Topics: Aged; Angina, Unstable; Aspirin; Double-Blind Method; Drug Therapy, Combination; Female; Fibrinolyti

1998
International, randomized, controlled trial of lamifiban (a platelet glycoprotein IIb/IIIa inhibitor), heparin, or both in unstable angina. The PARAGON Investigators. Platelet IIb/IIIa Antagonism for the Reduction of Acute coronary syndrome events in a Gl
    Circulation, 1998, Jun-23, Volume: 97, Issue:24

    Topics: Acetates; Aged; Angina, Unstable; Anticoagulants; Aspirin; Female; Hemorrhage; Heparin; Humans; Male

1998
Randomised comparison of implantation of heparin-coated stents with balloon angioplasty in selected patients with coronary artery disease (Benestent II)
    Lancet (London, England), 1998, Aug-29, Volume: 352, Issue:9129

    Topics: Adult; Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspi

1998
Long-term oral anticoagulant therapy in patients with unstable angina or suspected non-Q-wave myocardial infarction: organization to assess strategies for ischemic syndromes (OASIS) pilot study results.
    Circulation, 1998, Sep-15, Volume: 98, Issue:11

    Topics: Administration, Oral; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Antithrombin

1998
Reduction of recurrent ischemia with abciximab during continuous ECG-ischemia monitoring in patients with unstable angina refractory to standard treatment (CAPTURE).
    Circulation, 1998, Oct-06, Volume: 98, Issue:14

    Topics: Abciximab; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin;

1998
[Antithrombotic agents in unstable angina. Review of clinical trials].
    Annales de cardiologie et d'angeiologie, 1998, Volume: 47, Issue:1

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Hirudin

1998
[Effectiveness of unstable angina pectoris treatment by aggregation inhibitors ticlid and aspirin].
    Klinicheskaia meditsina, 1998, Volume: 76, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Electrocardiography, Ambulatory; Female;

1998
Effects of aprotinin during cardiopulmonary bypass in patients treated with acetylsalicylic acid.
    Scandinavian cardiovascular journal : SCJ, 1998, Volume: 32, Issue:5

    Topics: Adenosine Triphosphate; Adult; Aged; Angina, Unstable; Aprotinin; Aspirin; Blood Loss, Surgical; Blo

1998
Attenuated severity of new acute ischemic events in patients with previous coronary heart disease receiving long-acting nitrates.
    Clinical cardiology, 1999, Volume: 22, Issue:4

    Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Calcium Channel Blo

1999
Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes. PURSUIT Investigators. Platelet IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy.
    The American journal of cardiology, 1999, Apr-15, Volume: 83, Issue:8

    Topics: Acute Disease; Aged; Angina, Unstable; Aspirin; Electrocardiography; Eptifibatide; Female; Follow-Up

1999
Effects of aspirin and trapidil on cardiovascular events after acute myocardial infarction. Japanese Antiplatelets Myocardial Infarction Study (JAMIS) Investigators.
    The American journal of cardiology, 1999, May-01, Volume: 83, Issue:9

    Topics: Aged; Angina, Unstable; Aspirin; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation I

1999
Stroke in patients with acute coronary syndromes: incidence and outcomes in the platelet glycoprotein IIb/IIIa in unstable angina. Receptor suppression using integrilin therapy (PURSUIT) trial. The PURSUIT Investigators.
    Circulation, 1999, May-11, Volume: 99, Issue:18

    Topics: Acute Disease; Age Factors; Aged; Angina, Unstable; Aspirin; Brain Damage, Chronic; Cerebral Hemorrh

1999
Coronary artery flow ten weeks after myocardial infarction or unstable angina: effects of combined warfarin and aspirin therapy.
    International journal of cardiology, 1999, Apr-30, Volume: 69, Issue:1

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Blood Flow Velocity; Coronary Angiography; Coronary Circu

1999
Glycoprotein IIb/IIIa receptor inhibition in interventional cardiology.
    Journal of thrombosis and thrombolysis, 1999, Volume: 7, Issue:3

    Topics: Abciximab; Administration, Oral; Adult; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Anti

1999
Randomized clinical trial of urokinase versus heparin in unstable angina.
    Journal of thrombosis and thrombolysis, 1999, Volume: 8, Issue:3

    Topics: Adult; Aged; Angina, Unstable; Aspirin; China; Dose-Response Relationship, Drug; Drug Therapy, Combi

1999
Design, baseline characteristics, and preliminary clinical results of the Organization to Assess Strategies for Ischemic Syndromes-2 (OASIS-2) trial.
    The American journal of cardiology, 1999, Sep-02, Volume: 84, Issue:5A

    Topics: Adult; Angina, Unstable; Anticoagulants; Aspirin; Death, Sudden, Cardiac; Double-Blind Method; Drug

1999
The Organization to Assess Strategies for Ischemic Syndromes (OASIS) Pilot Study: evaluation of acute and long-term therapies for patients with acute coronary syndromes without ST elevation.
    The American journal of cardiology, 1999, Sep-02, Volume: 84, Issue:5A

    Topics: Acute Disease; Aged; Angina, Unstable; Anticoagulants; Aspirin; Canada; Death, Sudden, Cardiac; Dose

1999
Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: a randomised trial. The SYMPHONY Investigators. Sibrafiban versus Aspirin to Yield Maximum Protection from Ischemic Heart Events Post-acute Coron
    Lancet (London, England), 2000, Jan-29, Volume: 355, Issue:9201

    Topics: Administration, Oral; Aged; Angina, Unstable; Aspirin; Double-Blind Method; Female; Humans; Male; Mi

2000
Long-term management--the way forward?
    Clinical cardiology, 2000, Volume: 23 Suppl 1

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Coronary Artery Disease; Dalteparin; Drug Therapy, Combin

2000
Antithrombotic effects of abciximab.
    The American journal of cardiology, 2000, May-15, Volume: 85, Issue:10

    Topics: Abciximab; Angina, Unstable; Antibodies, Monoclonal; Aspirin; Drug Therapy, Combination; Fibrinolyti

2000
Predictors of recurrent ischemic events and death in unstable coronary artery disease after treatment with combination antithrombotic therapy.
    American heart journal, 2000, Volume: 139, Issue:6

    Topics: Aged; Angina, Unstable; Aspirin; Drug Administration Routes; Drug Therapy, Combination; Electrocardi

2000
Effects of various anticoagulant treatments on von Willebrand factor release in unstable angina.
    Journal of the American College of Cardiology, 2000, Volume: 36, Issue:1

    Topics: Aged; Angina, Unstable; Anticoagulants; Antithrombins; Aspirin; Biomarkers; Blood Platelets; Daltepa

2000
Oxidant stress and aspirin-insensitive thromboxane biosynthesis in severe unstable angina.
    Circulation, 2000, Aug-29, Volume: 102, Issue:9

    Topics: Angina, Unstable; Antioxidants; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprost; Dose-Respons

2000
[Clinical effectiveness and specific action of antiaggregants in patients with unstable angina].
    Klinicheskaia meditsina, 2000, Volume: 78, Issue:7

    Topics: Angina, Unstable; Aspirin; Electrocardiography, Ambulatory; Female; Hemostasis; Humans; Male; Middle

2000
Glycoprotein IIb/IIIa receptor blockade improves outcomes in diabetic patients presenting with unstable angina/non-ST-elevation myocardial infarction: results from the Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Uns
    Circulation, 2000, Nov-14, Volume: 102, Issue:20

    Topics: Aged; Angina, Unstable; Anticoagulants; Aspirin; Diabetes Complications; Disease Progression; Double

2000
Effect of aspirin and ticlopidine on plasma tissue factor levels in stable and unstable angina pectoris.
    The American journal of cardiology, 2000, Mar-01, Volume: 85, Issue:5

    Topics: Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Antithrombin III; Aspirin; Athere

2000
The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial programme; rationale, design and baseline characteristics including a meta-analysis of the effects of thienopyridines in vascular disease.
    European heart journal, 2000, Volume: 21, Issue:24

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Humans; Meta-Analysis as Topic; Platelet Aggregation Inhibit

2000
Safety and preliminary efficacy of one month glycoprotein IIb/IIIa inhibition with lefradafiban in patients with acute coronary syndromes without ST-elevation; a phase II study.
    European heart journal, 2000, Volume: 21, Issue:24

    Topics: Aged; Angina, Unstable; Anticoagulants; Aspirin; Biphenyl Compounds; Double-Blind Method; Female; He

2000
Effects of long-term, moderate-intensity oral anticoagulation in addition to aspirin in unstable angina. The Organization to Assess Strategies for Ischemic Syndromes (OASIS) Investigators.
    Journal of the American College of Cardiology, 2001, Volume: 37, Issue:2

    Topics: Administration, Oral; Adult; Aged; Angina, Unstable; Anticoagulants; Aspirin; Dose-Response Relation

2001
Prior aspirin users with acute non-ST-elevation coronary syndromes are at increased risk of cardiac events and benefit from enoxaparin.
    American heart journal, 2001, Volume: 141, Issue:4

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Double-Blind Method; Enoxaparin; Female; Heparin; Humans;

2001
Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes.
    Thrombosis and haemostasis, 2001, Volume: 85, Issue:3

    Topics: Acute Disease; Adenosine Monophosphate; Adult; Aged; Angina, Unstable; Aspirin; Blood Coagulation Te

2001
Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban.
    The New England journal of medicine, 2001, Jun-21, Volume: 344, Issue:25

    Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Combined Modality Therapy; Coronary

2001
Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban.
    The New England journal of medicine, 2001, Jun-21, Volume: 344, Issue:25

    Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Combined Modality Therapy; Coronary

2001
Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban.
    The New England journal of medicine, 2001, Jun-21, Volume: 344, Issue:25

    Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Combined Modality Therapy; Coronary

2001
Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban.
    The New England journal of medicine, 2001, Jun-21, Volume: 344, Issue:25

    Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Combined Modality Therapy; Coronary

2001
Genetic variation in glycoprotein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes.
    Blood, 2001, Dec-01, Volume: 98, Issue:12

    Topics: Aged; Alanine; Angina, Unstable; Antigens, Human Platelet; Aspirin; Double-Blind Method; Female; Gen

2001
[Effect of Composite Salviae Dropping Pill on function of platelet activation in patients with unstable angina pectoris].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2000, Volume: 20, Issue:6

    Topics: Adult; Aged; Angina, Unstable; Aspirin; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Hu

2000
Insights from CURE: using clopidogrel on top of standard therapy.
    Cerebrovascular diseases (Basel, Switzerland), 2002, Volume: 13 Suppl 1

    Topics: Aged; Angina, Unstable; Aspirin; Clopidogrel; Double-Blind Method; Female; Follow-Up Studies; Hepari

2002
[Comparative efficacy of tiklid and aspirin in patients with unstable angina].
    Terapevticheskii arkhiv, 2001, Volume: 73, Issue:12

    Topics: Angina, Unstable; Aspirin; Blood Coagulation; Endothelium, Vascular; Female; Fibrinolytic Agents; Hu

2001
Prognostic significance of elevated troponin I after percutaneous coronary intervention.
    Journal of the American College of Cardiology, 2002, Jun-05, Volume: 39, Issue:11

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Creatine Kinase; Creatine Kin

2002
Efficacy assessment of meloxicam, a preferential cyclooxygenase-2 inhibitor, in acute coronary syndromes without ST-segment elevation: the Nonsteroidal Anti-Inflammatory Drugs in Unstable Angina Treatment-2 (NUT-2) pilot study.
    Circulation, 2002, Jul-09, Volume: 106, Issue:2

    Topics: Acute Disease; Adult; Aged; Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Coro

2002
Coronary revascularisation in insulin-dependent diabetic patients with chronic renal failure.
    Lancet (London, England), 1992, Oct-24, Volume: 340, Issue:8826

    Topics: Adult; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Calcium Channel Blockers; Coronary

1992
Randomized trial of thrombolysis versus heparin in unstable angina.
    Circulation, 1992, Volume: 86, Issue:5

    Topics: Angina, Unstable; Aspirin; Female; Heparin; Humans; Incidence; Male; Middle Aged; Myocardial Infarct

1992
Diagnostic and prognostic importance of ST recording after an episode of unstable angina or non-Q-wave myocardial infarction.
    European heart journal, 1992, Volume: 13, Issue:2

    Topics: Administration, Oral; Adult; Aged; Angina, Unstable; Aspirin; Coronary Care Units; Double-Blind Meth

1992
Reactivation of unstable angina after the discontinuation of heparin.
    The New England journal of medicine, 1992, Jul-16, Volume: 327, Issue:3

    Topics: Acute Disease; Angina, Unstable; Aspirin; Double-Blind Method; Drug Therapy, Combination; Female; He

1992
Thrombolytic therapy in refractory unstable angina: the role of Holter monitoring.
    Clinical cardiology, 1991, Volume: 14, Issue:4

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Aspirin; Calcium Channel Blockers; Electrocardiograph

1991
Should the exercise test (ET) be performed at discharge or one month later after an episode of unstable angina or non-Q-wave myocardial infarction?
    International journal of cardiac imaging, 1991, Volume: 7, Issue:1

    Topics: Angina, Unstable; Aspirin; Double-Blind Method; Electrocardiography; Exercise Test; Follow-Up Studie

1991
Aspirin (75 mg/day) after an episode of unstable coronary artery disease: long-term effects on the risk for myocardial infarction, occurrence of severe angina and the need for revascularization. Research Group on Instability in Coronary Artery Disease in
    Journal of the American College of Cardiology, 1991, Volume: 18, Issue:7

    Topics: Administration, Oral; Angina, Unstable; Aspirin; Coronary Angiography; Electrocardiography; Follow-U

1991
Effect of heparin, aspirin, or alteplase in reduction of myocardial ischaemia in refractory unstable angina.
    Lancet (London, England), 1990, Mar-17, Volume: 335, Issue:8690

    Topics: Administration, Oral; Aged; Analysis of Variance; Angina Pectoris; Angina, Unstable; Aspirin; Double

1990
Ticlopidine in unstable angina. A more expensive aspirin?
    Circulation, 1990, Volume: 82, Issue:1

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Clinical Trials as Topic; Cost-Benefit Analysis; Cycloox

1990
Intravenous recombinant tissue-type plasminogen activator in patients with unstable angina pectoris. Results of a placebo-controlled, randomized trial.
    Circulation, 1990, Volume: 82, Issue:2

    Topics: Aged; Angina Pectoris; Angina, Unstable; Angiography; Aspirin; Cardiac Catheterization; Coronary Ang

1990
Long-term maintenance of thromboxane inhibition by two different aspirin regimens in patients with unstable angina.
    Thrombosis research, 1990, Oct-15, Volume: 60, Issue:2

    Topics: Angina, Unstable; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dose-Response Relationship, D

1990
[Anticoagulantion and antiaggregation therapy in patients with unstableangina pectoris].
    Vnitrni lekarstvi, 1990, Volume: 36, Issue:6

    Topics: Angina, Unstable; Aspirin; Dipyridamole; Drug Therapy, Combination; Electrocardiography; Female; Hep

1990
Ticlopidine in unstable angina.
    Circulation, 1990, Volume: 82, Issue:6

    Topics: Angina, Unstable; Aspirin; Humans; Platelet Aggregation Inhibitors; Ticlopidine

1990
Dissociation of platelet activation and spontaneous myocardial ischemia in unstable angina.
    Thrombosis and haemostasis, 1990, Apr-12, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Coron

1990
Unstable angina or non-Q wave infarction despite long-term aspirin: response to thrombolytic therapy with implications on mechanisms.
    American heart journal, 1990, Volume: 120, Issue:2

    Topics: Aged; Angina Pectoris; Angina, Unstable; Angiography; Aspirin; Biomechanical Phenomena; Cerebral Hem

1990
Comparison of low-dose aspirin and coronary vasodilators in acute unstable angina.
    Circulation, 1990, Volume: 81, Issue:1 Suppl

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Diltiazem; Drug Therapy, Combination; Electrocardiograph

1990
Restoration of flow in acute coronary obstructive syndromes: consequences of different management strategies.
    The Canadian journal of cardiology, 1989, Volume: 5, Issue:3

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Clinical Trials as Topic; Coronary Circulation; Humans;

1989
Comparative study of heparin and antiplatelets in treatment of preinfarction angina.
    Cardiologia (Rome, Italy), 1989, Volume: 34, Issue:2

    Topics: Adult; Aged; Angina Pectoris; Angina, Unstable; Aspirin; Clinical Trials as Topic; Dipyridamole; Dru

1989
Current perspectives in the antiplatelet therapy of thrombotic disorders.
    Seminars in thrombosis and hemostasis, 1989, Volume: 15, Issue:2

    Topics: Angina, Unstable; Aspirin; Clinical Trials as Topic; Coronary Disease; Coronary Thrombosis; Humans;

1989
Aspirin for prevention of myocardial infarction and stroke.
    The Medical letter on drugs and therapeutics, 1989, Aug-25, Volume: 31, Issue:799

    Topics: Angina, Unstable; Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Humans; Ischemic Att

1989
[Do thrombocyte aggregation inhibitors modify silent episodes of unstable angina pectoris in combined anti-angina therapy?].
    Zeitschrift fur Kardiologie, 1989, Volume: 78 Suppl 2

    Topics: Aged; Angina Pectoris; Angina, Unstable; Aspirin; Coronary Circulation; Diltiazem; Drug Therapy, Com

1989
Urokinase plus heparin versus aspirin in unstable angina and non-Q-wave myocardial infarction.
    The American journal of cardiology, 1989, Oct-15, Volume: 64, Issue:14

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Coronary Angiography; Drug Therapy, Combination; Electro

1989
Prevention of coronary heart disease in practice. Implications of the results of recent clinical trials.
    JAMA, 1985, Jul-12, Volume: 254, Issue:2

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina, Unstable; Aspirin; Blood Platelets; Cholesterol; C

1985
Comparison of medical and surgical treatment for unstable angina pectoris. Results of a Veterans Administration Cooperative Study.
    The New England journal of medicine, 1987, Apr-16, Volume: 316, Issue:16

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Angiography; Aspirin; Clinical Trial

1987
Aspirin, heparin, or both to treat acute unstable angina.
    The New England journal of medicine, 1988, Oct-27, Volume: 319, Issue:17

    Topics: Acute Disease; Angina Pectoris; Angina, Unstable; Aspirin; Clinical Trials as Topic; Double-Blind Me

1988
Clinical trials of antiplatelet drug therapy in acute myocardial infarction, unstable angina, and aortocoronary bypass surgery.
    Cardiovascular clinics, 1987, Volume: 18, Issue:1

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Blood Platelets; Clinical Trials as Topic; Coronary Arte

1987
Antithrombotic agents in coronary artery disease.
    Chest, 1986, Volume: 89, Issue:2 Suppl

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Blood Platelets; Clinical Trials as Topic; Coronary Disea

1986
Aspirin to prevent myocardial infarction and death.
    The Medical letter on drugs and therapeutics, 1986, Mar-14, Volume: 28, Issue:709

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Clinical Trials as Topic; Female; Humans; Male; Myocardi

1986
Effectiveness of anticoagulants.
    Seminars in thrombosis and hemostasis, 1986, Volume: 12, Issue:1

    Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Angina, Unstable; Anticoagulants; Aspirin; Blood

1986
Aspirin for the prevention of coronary thrombosis: current facts and perspectives.
    European heart journal, 1986, Volume: 7, Issue:6

    Topics: Angina, Unstable; Animals; Aspirin; Clinical Trials as Topic; Coronary Artery Bypass; Coronary Disea

1986
[Controversy on platelet-inhibiting drugs].
    Schweizerische medizinische Wochenschrift, 1985, May-18, Volume: 115, Issue:20

    Topics: Angina, Unstable; Aspirin; Blood Platelets; Cerebrovascular Disorders; Clinical Trials as Topic; Cor

1985
Aspirin, sulfinpyrazone, or both in unstable angina. Results of a Canadian multicenter trial.
    The New England journal of medicine, 1985, Nov-28, Volume: 313, Issue:22

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Ther

1985
Unstable angina: status of aspirin and other forms of therapy.
    Circulation, 1985, Volume: 72, Issue:6 Pt 2

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Clinical Trials as Topic; Coronary Artery Bypass; Double

1985

Other Studies

202 other studies available for aspirin and Angina, Unstable

ArticleYear
Impact of Anemia on the Risk of Bleeding Following Percutaneous Coronary Interventions in Patients ≥75 Years of Age.
    The American journal of cardiology, 2020, 04-15, Volume: 125, Issue:8

    Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Anemia; Angina, Unstable; Anticoagulants; Antithro

2020
Net platelet clot strength of thromboelastography platelet mapping assay for the identification of high on-treatment platelet reactivity in post-PCI patients.
    Bioscience reports, 2020, 07-31, Volume: 40, Issue:7

    Topics: Aged; Angina, Unstable; Aspirin; Blood Platelets; Female; Humans; Male; Middle Aged; Myocardial Infa

2020
Acute coronary syndromes: summary of updated NICE guidance.
    BMJ (Clinical research ed.), 2021, 01-15, Volume: 372

    Topics: Acute Coronary Syndrome; Angina, Unstable; Aspirin; Cardiac Rehabilitation; Clopidogrel; Combined Mo

2021
Outcomes of Individuals With and Without Heart Failure Presenting With Acute Coronary Syndrome.
    The American journal of cardiology, 2021, 06-01, Volume: 148

    Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Case-Control Studies; Clopidogrel; Diabete

2021
Treatment Outcomes of Clopidogrel in Patients With ACS and Diabetes Undergoing PCI-Analysis of Beijing Municipal Medical Insurance Database.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Acute Coronary Syndrome; Angina, Unstable; Aspirin; Beijing; Clopidogrel; Databases, Factual; Diabet

2021
Pragmatic approach to chest pain patients discharged with undetectable high-sensitivity troponin T and normal electrocardiogram: the STABS + CT protocol.
    Internal medicine journal, 2017, Volume: 47, Issue:6

    Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Aspirin; Biomarkers; Chest Pain; Computed Tomog

2017
[Focused update on dual antiplatelet treatment : ESC guidelines 2017].
    Herz, 2017, Volume: 42, Issue:8

    Topics: Acute Coronary Syndrome; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Com

2017
[Platelet inhibition in elderly patients].
    Herz, 2018, Volume: 43, Issue:3

    Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Humans; Percutaneous Coronary Intervention

2018
Long-term follow-up of antithrombotic management patterns in acute coronary syndrome patients.
    Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2018, Volume: 46, Issue:3

    Topics: Acute Coronary Syndrome; Angina, Unstable; Anticoagulants; Aspirin; Female; Follow-Up Studies; Human

2018
[Special characteristics of progression of myocardial remodeling in patients with various forms of unstable angina].
    Kardiologiia, 2014, Volume: 54, Issue:7

    Topics: Aged; Angina, Unstable; Aspirin; Benzopyrans; Cardiovascular Agents; Disease Progression; Drug Thera

2014
T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2016, Volume: 17, Issue:8

    Topics: Acute Coronary Syndrome; Aged; Alleles; Angina, Unstable; Aspirin; Atrial Natriuretic Factor; Female

2016
[Two catheters for one coronary perforation].
    Giornale italiano di cardiologia (2006), 2015, Volume: 16, Issue:2

    Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Antihypertensive Agents; Aspirin; Cardiac Ca

2015
Use of Health Care System-Supplied Aspirin by Veterans With Postoperative Heart Attack or Unstable Angina.
    The American journal of the medical sciences, 2015, Volume: 350, Issue:4

    Topics: Aged; Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiology; Evidence-Based

2015
Management of acute coronary syndromes in a developing country; time for a paradigm shift? an observational study.
    BMC cardiovascular disorders, 2015, Oct-24, Volume: 15

    Topics: Acute Coronary Syndrome; Aged; Alcoholism; Angina, Unstable; Aspirin; Delayed Diagnosis; Developing

2015
Pre-hospital management of acute coronary syndrome patients in Belgium and Luxembourg and other Western European countries.
    Acta cardiologica, 2016, Volume: 71, Issue:1

    Topics: Acute Coronary Syndrome; Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Belgium

2016
Searching the right coronary artery we found a rare anomaly documented by 3-dimensional volume rendering.
    International journal of cardiology, 2016, Nov-01, Volume: 222

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Aspirin; Computed Tomography Angiography; Conservativ

2016
Relationship of Platelet Reactivity With Bleeding Outcomes During Long-Term Treatment With Dual Antiplatelet Therapy for Medically Managed Patients With Non-ST-Segment Elevation Acute Coronary Syndromes.
    Journal of the American Heart Association, 2016, 11-04, Volume: 5, Issue:11

    Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Blood Platelets; Clopidogrel; Drug Therapy

2016
[Acute coronary syndrome -- long term protection by dual thrombocyte aggregation inhibition during twelve months].
    MMW Fortschritte der Medizin, 2008, Oct-16, Volume: 150, Issue:42

    Topics: Acute Coronary Syndrome; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clinical Trials

2008
Responsiveness to aspirin in patients with unstable angina pectoris by whole blood aggregometry.
    International journal of clinical practice, 2009, Volume: 63, Issue:3

    Topics: Aged; Angina, Unstable; Aspirin; Drug Resistance; Electric Impedance; Female; Humans; Male; Middle A

2009
Incidence and prognostic significance of thrombocytopenia developed during acute coronary syndrome in contemporary clinical practice.
    Circulation, 2009, May-12, Volume: 119, Issue:18

    Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angina, Unstable; Anticoagulants; Aspirin; Clopido

2009
Combined carotid stenting and urgent coronary artery surgery in unstable angina patients with severe carotid stenosis.
    Interactive cardiovascular and thoracic surgery, 2009, Volume: 9, Issue:2

    Topics: Aged; Aged, 80 and over; Angina, Unstable; Angioplasty, Balloon; Anticoagulants; Aspirin; Carotid St

2009
The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2009, Volume: 20, Issue:6

    Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Comorbidity; Drug Resistance; Electrocardi

2009
Weighing benefits and risks--the FDA's review of prasugrel.
    The New England journal of medicine, 2009, Sep-03, Volume: 361, Issue:10

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Causality; Clini

2009
Temporal trends in patient-reported angina at 1 year after percutaneous coronary revascularization in the stent era: a report from the National Heart, Lung, and Blood Institute-sponsored 1997-2006 dynamic registry.
    Circulation. Cardiovascular quality and outcomes, 2009, Volume: 2, Issue:6

    Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; An

2009
Anxiety is a better predictor of platelet reactivity in coronary artery disease patients than depression.
    European heart journal, 2010, Volume: 31, Issue:13

    Topics: Adenosine Diphosphate; Aged; Angina, Unstable; Anxiety Disorders; Aspirin; Clopidogrel; Cross-Sectio

2010
Hemorrhagic cholecystitis after anticoagulation therapy.
    The American journal of the medical sciences, 2010, Volume: 340, Issue:4

    Topics: Adenocarcinoma; Aged; Angina, Unstable; Anticoagulants; Aspirin; Cholecystitis; Female; Gallbladder

2010
[Registries of myocardial infarction in Germany. Consequences for drug therapy of patients with acute ST elevation myocardial infarction].
    Der Internist, 2010, Volume: 51, Issue:10

    Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angina, Unstable; Angioplasty, Balloon, Corona

2010
Aspirin desensitization/challenge in 3 patients with unstable angina.
    The American journal of the medical sciences, 2010, Volume: 340, Issue:5

    Topics: Angina, Unstable; Aspirin; Desensitization, Immunologic; Humans; Male; Middle Aged; Platelet Aggrega

2010
Dosing of clopidogrel and aspirin in acute coronary syndromes.
    The New England journal of medicine, 2010, 12-16, Volume: 363, Issue:25

    Topics: Acute Coronary Syndrome; Algorithms; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clop

2010
Differences in the mode of presentation for acute coronary syndrome by pre-hospitalization medication, in relation to coronary risk factors, East-Osaka acute coronary syndrome (EACS) registry.
    Atherosclerosis, 2011, Volume: 219, Issue:1

    Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Aged; Angina, Unstable; Aspirin; Coronary Arte

2011
Aneurysm formation after drug-eluting balloon treatment of drug-eluting in-stent restenosis: first case report.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2012, Dec-01, Volume: 80, Issue:7

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Cardiac Catheters; Cardiovascular Agents;

2012
Economic evaluation of clopidogrel in acute coronary syndrome patients without ST-segment elevation in Greece: a cost-utility analysis.
    Applied health economics and health policy, 2012, Jul-01, Volume: 10, Issue:4

    Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Clopidogrel; Computer Simulation; Cost-Ben

2012
Follow-up of aspirin-resistant patients with end-stage kidney disease.
    International urology and nephrology, 2013, Volume: 45, Issue:4

    Topics: Aged; Angina, Unstable; Area Under Curve; Aspirin; Cause of Death; Cohort Studies; Drug Resistance;

2013
[New US guidelines. Myocardial infarct is now treated more aggressively].
    MMW Fortschritte der Medizin, 2002, May-16, Volume: 144, Issue:20

    Topics: Angina, Unstable; Aspirin; Cerebral Infarction; Clopidogrel; Drug Therapy, Combination; Humans; Myoc

2002
Management of acute coronary syndromes. Variations in practice and outcome; findings from the Global Registry of Acute Coronary Events (GRACE).
    European heart journal, 2002, Volume: 23, Issue:15

    Topics: Acute Disease; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Australia; Canada; E

2002
[Role of emergency departments in acute myocardial infarction care. EVICURE study].
    Revista espanola de cardiologia, 2002, Volume: 55, Issue:10

    Topics: Aged; Angina, Unstable; Aspirin; Coronary Care Units; Diagnosis, Differential; Emergency Service, Ho

2002
Clopidogrel plus aspirin for stroke prevention.
    Stroke, 2002, Volume: 33, Issue:11

    Topics: Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Follow-

2002
A partial CURE for acute coronary syndromes--but how did it happen?
    European heart journal, 2002, Volume: 23, Issue:22

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Platele

2002
Frequency and correlates of coronary stent thrombosis in the modern era: analysis of a single center registry.
    Journal of the American College of Cardiology, 2002, Nov-06, Volume: 40, Issue:9

    Topics: Aged; Aged, 80 and over; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cor

2002
New treatment guidelines for unstable angina/non-ST-segment elevation myocardial infartion.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:11

    Topics: Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Heparin, Low-Molecu

2002
[New guidelines in acute coronary syndrome. Clopidogrel for nine months is recommended].
    MMW Fortschritte der Medizin, 2002, Oct-03, Volume: 144, Issue:40

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Hum

2002
[Baseline characteristics and management of patients less than 45 years of age hospitalized for acute coronary syndromes: results from the nationwide French PREVENIR 1 and PREVENIR 2 studies].
    Annales de cardiologie et d'angeiologie, 2002, Volume: 51, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Angina, Unstable; Angiotensin-Converting Enzyme Inh

2002
[Prospective analysis of conservative treatment of acute coronary syndrome].
    Kardiologiia, 2002, Volume: 42, Issue:5

    Topics: Acute Disease; Adult; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Cor

2002
Unstable angina and non-Q-wave myocardial infarction. Treatment beyond aspirin and heparin.
    Cardiologia (Rome, Italy), 1999, Volume: 44 Suppl 1, Issue:Pt 2

    Topics: Angina, Unstable; Aspirin; Electrocardiography; Fibrinolytic Agents; Heparin; Humans; Myocardial Inf

1999
[In acute coronary syndrome. Seize platelets with pliers].
    MMW Fortschritte der Medizin, 2002, Nov-07, Volume: 144, Issue:45

    Topics: Acute Disease; Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Cyclooxygenase Inhi

2002
Prior aspirin use in unstable angina patients with modified plasma inflammatory markers and endothelial nitric oxide synthase in neutrophils.
    European journal of clinical investigation, 2002, Volume: 32, Issue:12

    Topics: Aged; Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Case-Control S

2002
Enoxaparin in unstable angina patients who would have been excluded from randomized pivotal trials.
    Journal of the American College of Cardiology, 2003, Jan-01, Volume: 41, Issue:1

    Topics: Aged; Aged, 80 and over; Angina, Unstable; Anticoagulants; Aspirin; Creatinine; Drug Monitoring; Eno

2003
Pharmacological treatment of acute coronary syndromes.
    Professional nurse (London, England), 2003, Volume: 18, Issue:5

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Aspirin; Clopidogrel; Humans; Myocardial Infarction;

2003
Spontaneous hemarthrosis of the knee associated with clopidogrel and aspirin treatment.
    Zeitschrift fur Rheumatologie, 2003, Volume: 62, Issue:1

    Topics: Aged; Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Coagulation Tests; C

2003
[Trends in discharge prescriptions for patients hospitalized for acute coronary syndromes in France from 1995 to 2000. Data from the Usik 1995, Prevenir 1, Prevenir 2 and Usic 2000 surveys].
    Annales de cardiologie et d'angeiologie, 2003, Volume: 52, Issue:1

    Topics: Acute Disease; Adrenergic beta-Antagonists; Aged; Angina, Unstable; Angiotensin-Converting Enzyme In

2003
Long-term prognosis of patients with acute coronary syndrome and moderate coronary artery stenosis.
    Cardiology, 2003, Volume: 99, Issue:2

    Topics: Acute Disease; Adrenergic beta-Antagonists; Aged; Angina, Unstable; Aspirin; Coronary Angiography; C

2003
Usefulness of an acute coronary syndrome pathway to improve adherence to secondary prevention guidelines.
    The American journal of cardiology, 2003, May-15, Volume: 91, Issue:10

    Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Angiotensin-Converting Enzyme Inhibitors; Aspir

2003
[Acute coronary syndrome. The second platelet inhibitor is self-paid].
    MMW Fortschritte der Medizin, 2003, Jun-12, Volume: 145, Issue:24

    Topics: Acute Disease; Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Cost-Benefit Analys

2003
The central role of platelet activation in determining the severity of acute coronary syndromes.
    Heart (British Cardiac Society), 2003, Volume: 89, Issue:10

    Topics: Angina, Unstable; Aspirin; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activa

2003
[Dual platelet inhibition with clopidogrel and ASS. Who profits from the combination?].
    MMW Fortschritte der Medizin, 2003, Jul-10, Volume: 145, Issue:27-28

    Topics: Acute Disease; Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Cyclooxygenase Inhi

2003
Antiplatelet therapy for ischemic heart disease.
    The New England journal of medicine, 2004, Jan-15, Volume: 350, Issue:3

    Topics: Abciximab; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopid

2004
Implications of upstream glycoprotein IIb/IIIa inhibition and coronary artery stenting in the invasive management of unstable angina/non-ST-elevation myocardial infarction: a comparison of the Thrombolysis In Myocardial Infarction (TIMI) IIIB trial and th
    Circulation, 2004, Feb-24, Volume: 109, Issue:7

    Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Combined Modality Therapy; Comorbid

2004
Safety and efficacy of aspirin, clopidogrel, and warfarin after coronary stent placement in patients with an indication for anticoagulation.
    American heart journal, 2004, Volume: 147, Issue:3

    Topics: Aged; Aged, 80 and over; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin;

2004
[Recommendations for cardiovascular rehabilitation in diabetes mellitus].
    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, 2003, Volume: 60, Issue:4

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Angioplasty, Balloon; Aspirin; Blood Glucose; Cardiov

2003
[Experience with the use of autoarterial conduits in coronary surgery].
    Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery, 2004, Volume: 10, Issue:1

    Topics: Anastomosis, Surgical; Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; A

2004
Long-term management of patients with unstable angina and non-ST-elevation MI.
    The Journal of family practice, 2004, Volume: 53, Issue:6

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Evidence-Based Medicine; Humans; Hydroxymethylglutaryl-CoA R

2004
Building evidence for early initiation of clopidogrel loading in non-ST-segment elevation acute coronary syndromes: going past the American College of Cardiology/American Heart Association guidelines.
    Annals of emergency medicine, 2004, Volume: 43, Issue:5

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; E

2004
[Combination is standard. Dual thrombocyte function inhibition in acute coronary syndrome].
    MMW Fortschritte der Medizin, 2004, Volume: 146 Suppl 1

    Topics: Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans;

2004
[Interview with Prof. Dr. H. J. Rupprecht about secondary prevention: what is the optimal thrombocyte function inhibition?].
    MMW Fortschritte der Medizin, 2004, Volume: 146 Suppl 1

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Long-Term Care; Myocardia

2004
Severe stenosis of anastomoses by using the symmetry aortic connector system.
    The Annals of thoracic surgery, 2004, Volume: 78, Issue:5

    Topics: Aged; Angina, Unstable; Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Arter

2004
[Use of assessment of aggregation of thrombocytes induced by cationic propyl gallate to estimate recurrence of cardiovascular complications].
    Vnitrni lekarstvi, 2004, Volume: 50, Issue:8

    Topics: Adult; Aged; Angina, Unstable; Aspirin; Drug Resistance; Female; Humans; Male; Myocardial Infarction

2004
Safety of stress testing during the evolution of unstable angina pectoris or non-ST-elevation myocardial infarction.
    The American journal of cardiology, 2004, Dec-15, Volume: 94, Issue:12

    Topics: Angina, Unstable; Aspirin; Exercise Test; Female; Heparin; Humans; Male; Middle Aged; Myocardial Inf

2004
Safety of stress testing during the evolution of unstable angina pectoris or non-ST-elevation myocardial infarction.
    The American journal of cardiology, 2004, Dec-15, Volume: 94, Issue:12

    Topics: Angina, Unstable; Aspirin; Exercise Test; Female; Heparin; Humans; Male; Middle Aged; Myocardial Inf

2004
Safety of stress testing during the evolution of unstable angina pectoris or non-ST-elevation myocardial infarction.
    The American journal of cardiology, 2004, Dec-15, Volume: 94, Issue:12

    Topics: Angina, Unstable; Aspirin; Exercise Test; Female; Heparin; Humans; Male; Middle Aged; Myocardial Inf

2004
Safety of stress testing during the evolution of unstable angina pectoris or non-ST-elevation myocardial infarction.
    The American journal of cardiology, 2004, Dec-15, Volume: 94, Issue:12

    Topics: Angina, Unstable; Aspirin; Exercise Test; Female; Heparin; Humans; Male; Middle Aged; Myocardial Inf

2004
Safety of stress testing during the evolution of unstable angina pectoris or non-ST-elevation myocardial infarction.
    The American journal of cardiology, 2004, Dec-15, Volume: 94, Issue:12

    Topics: Angina, Unstable; Aspirin; Exercise Test; Female; Heparin; Humans; Male; Middle Aged; Myocardial Inf

2004
Safety of stress testing during the evolution of unstable angina pectoris or non-ST-elevation myocardial infarction.
    The American journal of cardiology, 2004, Dec-15, Volume: 94, Issue:12

    Topics: Angina, Unstable; Aspirin; Exercise Test; Female; Heparin; Humans; Male; Middle Aged; Myocardial Inf

2004
Safety of stress testing during the evolution of unstable angina pectoris or non-ST-elevation myocardial infarction.
    The American journal of cardiology, 2004, Dec-15, Volume: 94, Issue:12

    Topics: Angina, Unstable; Aspirin; Exercise Test; Female; Heparin; Humans; Male; Middle Aged; Myocardial Inf

2004
Safety of stress testing during the evolution of unstable angina pectoris or non-ST-elevation myocardial infarction.
    The American journal of cardiology, 2004, Dec-15, Volume: 94, Issue:12

    Topics: Angina, Unstable; Aspirin; Exercise Test; Female; Heparin; Humans; Male; Middle Aged; Myocardial Inf

2004
Safety of stress testing during the evolution of unstable angina pectoris or non-ST-elevation myocardial infarction.
    The American journal of cardiology, 2004, Dec-15, Volume: 94, Issue:12

    Topics: Angina, Unstable; Aspirin; Exercise Test; Female; Heparin; Humans; Male; Middle Aged; Myocardial Inf

2004
Gender differences in therapy for patients admitted for unstable angina and myocardial infarction with underlying chronic kidney disease.
    Hawaii medical journal, 2004, Volume: 63, Issue:11

    Topics: Acute Disease; Aged; Aged, 80 and over; Angina, Unstable; Angiotensin-Converting Enzyme Inhibitors;

2004
Long-term combination therapy with aspirin and clopidogrel.
    Journal of cardiovascular pharmacology and therapeutics, 2004, Volume: 9, Issue:4

    Topics: Angina, Unstable; Arteriosclerosis; Aspirin; Clopidogrel; Cyclooxygenase Inhibitors; Double-Blind Me

2004
Summaries for patients. Is it cost-effective to treat high-risk cardiac patients with clopidogrel plus aspirin as opposed to aspirin alone?
    Annals of internal medicine, 2005, Feb-15, Volume: 142, Issue:4

    Topics: Angina, Unstable; Aspirin; Cardiovascular Diseases; Clopidogrel; Computer Simulation; Cost-Benefit A

2005
A cost-effectiveness analysis of combination antiplatelet therapy for high-risk acute coronary syndromes: clopidogrel plus aspirin versus aspirin alone.
    Annals of internal medicine, 2005, Feb-15, Volume: 142, Issue:4

    Topics: Angina, Unstable; Aspirin; Cardiovascular Diseases; Clopidogrel; Computer Simulation; Cost-Benefit A

2005
Impact of combined pharmacologic treatment with clopidogrel and a statin on outcomes of patients with non-ST-segment elevation acute coronary syndromes: perspectives from a large multinational registry.
    European heart journal, 2005, Volume: 26, Issue:11

    Topics: Adolescent; Adult; Aged; Angina, Unstable; Aspirin; Clopidogrel; Drug Therapy, Combination; Female;

2005
Unstable angina, stroke, myocardial infarction and death in aspirin non-responders. A prospective, randomized trial. The ASCET (ASpirin non-responsiveness and Clopidogrel Endpoint Trial) design.
    Scandinavian cardiovascular journal : SCJ, 2004, Volume: 38, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Blood Platelets; Clopidogrel;

2004
An acute inflammatory reaction induced by myocardial damage is superimposed on a chronic inflammation in unstable coronary artery disease.
    American heart journal, 2005, Volume: 149, Issue:4

    Topics: Abciximab; Adult; Aged; Angina, Unstable; Antibodies, Monoclonal; Anticoagulants; Aspirin; C-Reactiv

2005
Medication performance measures and mortality following acute coronary syndromes.
    The American journal of medicine, 2005, Volume: 118, Issue:8

    Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Angina, Unstable; Angiotensin-Converting Enzyme Inhi

2005
Inflammatory response after intervention assessed by serial C-reactive protein measurements correlates with restenosis in patients treated with coronary stenting.
    American heart journal, 2005, Volume: 150, Issue:2

    Topics: Abciximab; Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Mono

2005
Cost-effectiveness of clopidogrel plus aspirin versus aspirin alone.
    Annals of internal medicine, 2005, Sep-20, Volume: 143, Issue:6

    Topics: Angina, Unstable; Aspirin; Cardiovascular Diseases; Clopidogrel; Cost-Benefit Analysis; Drug Therapy

2005
Cost-effectiveness of clopidogrel plus aspirin versus aspirin alone.
    Annals of internal medicine, 2005, Sep-20, Volume: 143, Issue:6

    Topics: Angina, Unstable; Aspirin; Cardiovascular Diseases; Clopidogrel; Cost-Benefit Analysis; Drug Therapy

2005
Outcomes of acute coronary syndrome in a large Canadian cohort: impact of chronic renal insufficiency, cardiac interventions, and anemia.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 46, Issue:5

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Anemia; Angina, Unstable; Angiotensin-Converting Enzyme In

2005
Potent low dose platelet inhibitory effects of clopidogrel and aspirin on coronary thrombus formation in an animal model of acute unstable angina.
    Thrombosis and haemostasis, 2006, Volume: 95, Issue:2

    Topics: Acute Disease; Angina, Unstable; Animals; Aspirin; Clopidogrel; Coronary Thrombosis; Disease Models,

2006
Embedded guideline information without patient specificity in a commercial emergency department computerized order-entry system.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2006, Volume: 13, Issue:4

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Aspirin; Clopidogrel; Decision Support Systems, Clini

2006
Delay in the diagnosis of acute myocardial infarction: effect on quality of care and its assessment.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2006, Volume: 13, Issue:9

    Topics: Adrenergic beta-Antagonists; Age Distribution; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; C

2006
[Bleeding complications after treatment with clopidogrel and acetylsalicylic acid after acute coronary syndrome].
    Ugeskrift for laeger, 2006, Sep-18, Volume: 168, Issue:38

    Topics: Age Factors; Aged; Angina, Unstable; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Com

2006
Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation.
    Journal of the American College of Cardiology, 2006, Oct-17, Volume: 48, Issue:8

    Topics: Acute Disease; Angina Pectoris; Angina, Unstable; Arteries; Aspirin; beta-Thromboglobulin; Blood Pla

2006
Persistent depressive symptoms lower aspirin adherence after acute coronary syndromes.
    American heart journal, 2006, Volume: 152, Issue:5

    Topics: Aged; Angina, Unstable; Aspirin; Depression; Female; Humans; Male; Middle Aged; Myocardial Infarctio

2006
Non-ST-elevation acute coronary syndromes.
    Lancet (London, England), 2007, Mar-10, Volume: 369, Issue:9564

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Aspirin; Cardiac Catheterization; Coronary Angiograph

2007
Self-reported use of complementary and alternative medicine in patients with previous acute coronary syndrome.
    The American journal of cardiology, 2007, Apr-01, Volume: 99, Issue:7

    Topics: Adrenergic beta-Antagonists; Aged; Analysis of Variance; Angina, Unstable; Aspirin; Complementary Th

2007
Patterns of aspirin dosing in non-ST-elevation acute coronary syndromes in the CRUSADE Quality Improvement Initiative.
    The American journal of cardiology, 2007, Jun-01, Volume: 99, Issue:11

    Topics: Acute Disease; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Clopidogrel; Coronary Artery Dise

2007
Aspirin is lifesaving for cancer patients with ACS. Benefits of aspirin treatment for patients with acute coronary syndrome are immediate.
    DukeMedicine healthnews, 2007, Volume: 13, Issue:5

    Topics: Angina, Unstable; Aspirin; Humans; Myocardial Infarction; Neoplasms; Platelet Aggregation Inhibitors

2007
[Soluble CD40 ligand: a potential marker of cardiovascular risk].
    Revista clinica espanola, 2007, Volume: 207, Issue:8

    Topics: Abciximab; Acute Coronary Syndrome; Alanine; Angina, Unstable; Animals; Antibodies, Monoclonal; Anti

2007
Serial changes in von Willebrand factor-cleaving protease (ADAMTS13) and prognosis after acute myocardial infarction.
    The American journal of cardiology, 2007, Sep-01, Volume: 100, Issue:5

    Topics: ADAM Proteins; ADAMTS13 Protein; Adult; Aged; Aged, 80 and over; Angina, Unstable; Anticoagulants; A

2007
Guideline-based discharge therapy for unstable angina pectoris/non-ST elevation myocardial infarction.
    Clinical cardiology, 2007, Volume: 30, Issue:10

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Electrocardiography; Humans; Hypolipidemic Agents; Myocardia

2007
Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease.
    Journal of the American College of Cardiology, 2007, Oct-16, Volume: 50, Issue:16

    Topics: Aged; Angina, Unstable; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Death, Sudde

2007
Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease.
    Journal of the American College of Cardiology, 2007, Oct-16, Volume: 50, Issue:16

    Topics: Aged; Angina, Unstable; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Death, Sudde

2007
Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease.
    Journal of the American College of Cardiology, 2007, Oct-16, Volume: 50, Issue:16

    Topics: Aged; Angina, Unstable; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Death, Sudde

2007
Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease.
    Journal of the American College of Cardiology, 2007, Oct-16, Volume: 50, Issue:16

    Topics: Aged; Angina, Unstable; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Death, Sudde

2007
Sweet and sticky: diabetic platelets, enhanced reactivity, and cardiovascular risk.
    Journal of the American College of Cardiology, 2007, Oct-16, Volume: 50, Issue:16

    Topics: Angina, Unstable; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Death, Sudden, Car

2007
The truth and consequences of the COURAGE trial.
    Journal of the American College of Cardiology, 2007, Oct-16, Volume: 50, Issue:16

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Coronary Ang

2007
2007 Focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2008, Jan-01, Volume: 71, Issue:1

    Topics: Acute Coronary Syndrome; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin;

2008
[Efficacy of intravenous aspirin use in patients with acute coronary syndrome].
    Zhonghua xin xue guan bing za zhi, 2007, Volume: 35, Issue:12

    Topics: Acute Coronary Syndrome; Administration, Oral; Adult; Aged; Aged, 80 and over; Angina, Unstable; Asp

2007
[Antiplatelet treatment after acute and chronic ischemic heart and brain events is insufficient according to recommendations].
    Ugeskrift for laeger, 2008, Mar-31, Volume: 170, Issue:14

    Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Angina Pectoris; Angina, Unstable; Aspirin;

2008
Failure of aspirin to prevent myocardial infarction and adverse outcome during follow-up - a large series of all-comers.
    Annals of medicine, 2008, Volume: 40, Issue:4

    Topics: Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Coronary Disease; Disease-Free Survival; Female;

2008
Positive predictive value of ICD-9 codes 410 and 411 in the identification of cases of acute coronary syndromes in the Saskatchewan Hospital automated database.
    Pharmacoepidemiology and drug safety, 2008, Volume: 17, Issue:8

    Topics: Acute Coronary Syndrome; Adult; Age Distribution; Aged; Aged, 80 and over; Angina, Unstable; Aspirin

2008
Unstable angina in a patient with mucocutaneous lymph node syndrome.
    Japanese heart journal, 1984, Volume: 25, Issue:4

    Topics: Aneurysm; Angina Pectoris; Angina, Unstable; Aspirin; Child; Coronary Angiography; Coronary Artery B

1984
Conversion from chronic to acute coronary artery disease: speculation regarding mechanisms.
    The American journal of cardiology, 1984, Dec-01, Volume: 54, Issue:10

    Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Angina, Unstable; Aorta; Aspirin; Blood Pres

1984
Treating unstable angina.
    The Journal of family practice, 1995, Volume: 41, Issue:6

    Topics: Adult; Aged; Angina, Unstable; Aspirin; Female; Heparin; Humans; Injections, Intravenous; Injections

1995
Heparin in unstable angina.
    Lancet (London, England), 1995, Jul-22, Volume: 346, Issue:8969

    Topics: Angina, Unstable; Aspirin; Drug Therapy, Combination; Female; Heparin; Humans; Infusions, Intravenou

1995
Heparin in unstable angina.
    Lancet (London, England), 1995, Jul-22, Volume: 346, Issue:8969

    Topics: Angina, Unstable; Aspirin; Drug Therapy, Combination; Female; Heparin; Humans; Infusions, Intravenou

1995
Previous aspirin use may attenuate the severity of the manifestation of acute ischemic syndromes.
    Circulation, 1995, Oct-01, Volume: 92, Issue:7

    Topics: Angina, Unstable; Aspirin; Case-Control Studies; Chest Pain; Electrocardiography; Female; Humans; Ma

1995
Increased number of thromboxane A2-prostaglandin H2 platelet receptors in active unstable angina and causative role of enhanced thrombin formation.
    American heart journal, 1995, Volume: 129, Issue:5

    Topics: Aged; Angina Pectoris; Angina, Unstable; Aspirin; Blood Platelets; Dose-Response Relationship, Drug;

1995
Management of cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia using prostaglandin E1 and aspirin.
    Journal of cardiothoracic and vascular anesthesia, 1994, Volume: 8, Issue:5

    Topics: Aged; Alprostadil; Angina, Unstable; Aspirin; Cardiopulmonary Bypass; Coronary Artery Bypass; Female

1994
Plasma lipoprotein(a) levels and fibrinolytic activity in patients with unstable angina.
    Japanese circulation journal, 1993, Volume: 57, Issue:10

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Calcium Chan

1993
[Sliding indications for balloon angioplasty].
    Nederlands tijdschrift voor geneeskunde, 1994, Jul-23, Volume: 138, Issue:30

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspi

1994
Antithrombin-III plasma activity during and after prolonged use of heparin in unstable angina.
    Thrombosis research, 1993, Oct-01, Volume: 72, Issue:1

    Topics: Angina, Unstable; Antithrombin III; Antithrombin III Deficiency; Aspirin; Female; Heparin; Humans; M

1993
Effects of aspirin DL-lysine on thrombin generation in unstable angina pectoris.
    The American journal of cardiology, 1993, May-15, Volume: 71, Issue:13

    Topics: Aged; Aged, 80 and over; Angina, Unstable; Antithrombin III; Aspirin; Blood Coagulation; Female; Hum

1993
Platelet activation in acute myocardial infarction and unstable angina is inhibited by nitric oxide donors.
    Arteriosclerosis, thrombosis, and vascular biology, 1996, Volume: 16, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Female; Flow Cytometry; Glutathione; Huma

1996
Low dose aspirin in patients with ischemic heart disease may precipitate secondary myocardial infarction.
    Israel journal of medical sciences, 1996, Volume: 32, Issue:5

    Topics: Aged; Angina, Unstable; Aspirin; Gastrointestinal Hemorrhage; Hemoglobins; Humans; Middle Aged; Myoc

1996
[Current point of view on medical treatment of unstable angina].
    Archives des maladies du coeur et des vaisseaux, 1996, Volume: 89 Spec No 5

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Anticoagulants; Aspirin; Fibrinolytic Agents; Heparin

1996
Benefit of heparin plus aspirin vs aspirin alone in unstable angina.
    JAMA, 1996, Dec-18, Volume: 276, Issue:23

    Topics: Angina, Unstable; Aspirin; Heparin; Humans; Meta-Analysis as Topic; Myocardial Infarction

1996
Benefit of heparin plus aspirin vs aspirin alone in unstable angina.
    JAMA, 1996, Dec-18, Volume: 276, Issue:23

    Topics: Angina, Unstable; Aspirin; Hemorrhage; Heparin; Humans; Myocardial Infarction

1996
Benefit of heparin plus aspirin vs aspirin alone in unstable angina.
    JAMA, 1996, Dec-18, Volume: 276, Issue:23

    Topics: Angina, Unstable; Aspirin; Hemorrhage; Heparin; Humans; Myocardial Infarction

1996
[Medical treatment of acute coronary syndrome].
    Cardiologia (Rome, Italy), 1995, Volume: 40, Issue:12 Suppl 1

    Topics: Acute Disease; Angina, Unstable; Aspirin; Coronary Disease; Fibrinolytic Agents; Heparin; Humans; Pl

1995
Increasing the stability of unstable angina.
    Archives of internal medicine, 1997, Jan-27, Volume: 157, Issue:2

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Dalteparin; Drug Therapy, Combination; Humans; Treatment

1997
Unstable coronary artery disease--need for long-term antithrombotic treatment. Aspirin alone is not sufficient, I would associate an anticoagulant.
    Cardiovascular research, 1997, Volume: 33, Issue:2

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Coronary Disease; Drug Therapy, Combination; Humans; Plat

1997
Outcome of unstable angina in patients with diabetes mellitus.
    Diabetic medicine : a journal of the British Diabetic Association, 1997, Volume: 14, Issue:3

    Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Angioplasty; Aspirin; Calcium Channel Blockers;

1997
Unstable angina: integrating new treatments.
    Hospital practice (1995), 1997, Oct-15, Volume: 32, Issue:10

    Topics: Abciximab; Angina, Unstable; Antibodies, Monoclonal; Aspirin; Contraindications; Drug Therapy, Combi

1997
[Low-dose ASA and infarct prophylaxis. Acetylsalicylic acid (ASA): low doses with high efficiency].
    Der Internist, 1995, Volume: 36, Issue:1 Suppl Lo

    Topics: Angina, Unstable; Aspirin; Dose-Response Relationship, Drug; Humans; Myocardial Infarction

1995
Early aggressive treatment of unstable angina without on-site cardiac surgical facilities: a prospective study of acute and long-term outcome.
    Giornale italiano di cardiologia, 1998, Volume: 28, Issue:2

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angina, Unstable; Angioplasty, Balloon,

1998
Aspirin for prevention of myocardial infarction. A double-edged sword.
    Annales de medecine interne, 1997, Volume: 148, Issue:6

    Topics: Aged; Aged, 80 and over; Anemia; Angina, Unstable; Aspirin; Female; Gastrointestinal Hemorrhage; Hum

1997
Trends in the quality of care for Medicare beneficiaries admitted to the hospital with unstable angina.
    Journal of the American College of Cardiology, 1998, Volume: 31, Issue:5

    Topics: Aged; Aged, 80 and over; Angina, Unstable; Anticoagulants; Aspirin; Connecticut; Female; Guideline A

1998
Platelet glycoprotein IIb/IIIa receptor blockade in unstable coronary disease.
    The New England journal of medicine, 1998, May-21, Volume: 338, Issue:21

    Topics: Angina, Unstable; Aspirin; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Humans; Myocardi

1998
[Effects of different lowdoses of aspirin on platelet activation and the number of platelets in the patients with coronary heart disease].
    Zhonghua nei ke za zhi, 1996, Volume: 35, Issue:8

    Topics: Aged; Angina, Unstable; Aspirin; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Aggregation

1996
Influence of insurance type on the use of procedures, medications and hospital outcome in patients with unstable angina: results from the GUARANTEE Registry. Global Unstable Angina Registry and Treatment Evaluation.
    Journal of the American College of Cardiology, 1998, Volume: 32, Issue:2

    Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Aspirin; Cardiac Catheterization; Cohort Studie

1998
Tirofiban in unstable coronary disease.
    The New England journal of medicine, 1998, Oct-15, Volume: 339, Issue:16

    Topics: Angina, Unstable; Aspirin; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Humans; Myocardi

1998
Low molecular weight heparins in acute ischaemic syndromes.
    Australian and New Zealand journal of medicine, 1998, Volume: 28, Issue:4

    Topics: Angina, Unstable; Aspirin; Female; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Male;

1998
New antiplatelet agents.
    Australian and New Zealand journal of medicine, 1998, Volume: 28, Issue:4

    Topics: Abciximab; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopid

1998
Coronary stenting in unstable angina: early and late clinical outcomes.
    The Canadian journal of cardiology, 1998, Volume: 14, Issue:9

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Coronary Artery Bypass; Coronary Disease;

1998
Effect of intravenous heparin infusion on thrombin-antithrombin complex and fibrinopeptide A in unstable angina.
    American heart journal, 1998, Volume: 136, Issue:6

    Topics: Aged; Angina, Unstable; Anticoagulants; Antithrombin III; Aspirin; Biomarkers; Female; Fibrinopeptid

1998
Eptifibatide in acute coronary syndromes.
    The New England journal of medicine, 1999, Jan-07, Volume: 340, Issue:1

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Eptifibatide; Heparin; Humans; Myocardial Infarction; Pep

1999
Super-aspirins in severe angina.
    Harvard heart letter : from Harvard Medical School, 1998, Volume: 9, Issue:4

    Topics: Angina, Unstable; Aspirin; Drug Therapy, Combination; Eptifibatide; Fibrinolytic Agents; Heparin; Hu

1998
Long-term oral platelet glycoprotein IIb/IIIa receptor antagonism with sibrafiban after acute coronary syndromes: study design of the sibrafiban versus aspirin to yield maximum protection from ischemic heart events post-acute coronary syndromes (SYMPHONY)
    American heart journal, 1999, Volume: 138, Issue:2 Pt 1

    Topics: Angina, Unstable; Aspirin; Clinical Trials, Phase III as Topic; Double-Blind Method; Humans; Myocard

1999
Four-year survival of patients with acute coronary syndromes without ST-segment elevation and prognostic significance of 0.5-mm ST-segment depression.
    The American journal of cardiology, 1999, Aug-15, Volume: 84, Issue:4

    Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Aspirin; Drug Therapy, Combination; Electrocard

1999
Trends in the post-hospitalization medical treatment of unstable angina pectoris: 1990 to 1995.
    The American journal of cardiology, 1999, Sep-15, Volume: 84, Issue:6

    Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Aspirin; Calcium Channel Blockers; Cohort Studi

1999
Enoxaparin and dalteparin in unstable angina: new indication. Enoxaparin: a reference treatment. Dalteparin: no better than unfractionated heparin.
    Prescrire international, 1999, Volume: 8, Issue:41

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Dalteparin; Enoxaparin; Humans; Myocardial Infarction; Tr

1999
[The rate of acetylsalicylic acid non-respondents among patients hospitalized for acute coronary disease, previously undergoing secondary salicylic acid prophylaxis].
    Orvosi hetilap, 1999, Oct-17, Volume: 140, Issue:42

    Topics: Acute Disease; Aged; Angina, Unstable; Aspirin; Coronary Disease; Drug Resistance; Female; Hospitali

1999
Clinical practice guidelines in unstable angina improve clinical outcomes by assuring early intensive medical treatment.
    Journal of the American College of Cardiology, 1999, Nov-15, Volume: 34, Issue:6

    Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Aspiri

1999
Low molecular weight heparins in acute coronary syndrome.
    South Dakota journal of medicine, 2000, Volume: 53, Issue:1

    Topics: Acute Disease; Angina, Unstable; Anticoagulants; Aspirin; Dalteparin; Double-Blind Method; Enoxapari

2000
Introduction: Expanding the horizons in unstable coronary artery disease.
    Clinical cardiology, 2000, Volume: 23 Suppl 1

    Topics: Angina, Unstable; Anticoagulants; Aspirin; Coronary Artery Disease; Coronary Thrombosis; Disease Man

2000
Guidelines for the diagnosis and management of unstable angina and non-Q-wave myocardial infarction: proposed revisions. International Cardiology Forum.
    American heart journal, 2000, Volume: 139, Issue:3

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Anticholesteremic Agents; Aspirin; Clinical Trials as

2000
Long-term outcome in patients treated by intracoronary stenting with ticlopidine and aspirin, and deleterious prognostic role of unstable angina pectoris.
    The American journal of cardiology, 2000, May-01, Volume: 85, Issue:9

    Topics: Aged; Angina, Unstable; Aspirin; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors;

2000
[Unstable angina pectoris: preventing the infarct. Thrombosis ABC, 14].
    MMW Fortschritte der Medizin, 2000, Mar-30, Volume: 142, Issue:13

    Topics: Angina, Unstable; Aspirin; Coronary Thrombosis; Heparin; Heparin, Low-Molecular-Weight; Humans; Prog

2000
Unstable angina pectoris.
    The New England journal of medicine, 2000, Jun-01, Volume: 342, Issue:22

    Topics: Angina, Unstable; Aspirin; Humans; Platelet Aggregation Inhibitors; Ticlopidine

2000
Heparin should be administered to every patient admitted to the hospital with possible unstable angina.
    The Western journal of medicine, 2000, Volume: 173, Issue:2

    Topics: Angina, Unstable; Aspirin; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Humans; Myoc

2000
Drip and ship: a new strategy for the treatment of acute coronary syndromes.
    Journal of thrombosis and thrombolysis, 2000, Volume: 10, Issue:1

    Topics: Abciximab; Acute Disease; Adult; Aged; Aged, 80 and over; Angina, Unstable; Antibodies, Monoclonal;

2000
Increased rate of formation of small-sized platelet aggregates in patients with acute coronary syndromes.
    Japanese circulation journal, 2000, Volume: 64, Issue:9

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Cohort Studies; Coronary D

2000
Antiplatelet drugs in cardiovascular prevention: coronary events: acute phase and secondary prevention.
    Prescrire international, 2000, Volume: 9, Issue:47

    Topics: Angina, Unstable; Angioplasty; Anticoagulants; Aspirin; Cardiovascular Diseases; Clinical Trials as

2000
Randomisation in the SYMPHONY trial.
    Lancet (London, England), 2000, Oct-28, Volume: 356, Issue:9240

    Topics: Angina, Unstable; Aspirin; Double-Blind Method; Humans; Oximes; Piperidines; Platelet Aggregation In

2000
[Therapy of acute coronary syndrome with glycoprotein IIb/IIIa antagonists].
    Medicina clinica, 2000, Oct-07, Volume: 115, Issue:11

    Topics: Abciximab; Acute Disease; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal;

2000
How hot is inflammation in acute coronary syndrome?
    European heart journal, 2000, Volume: 21, Issue:24

    Topics: Angina, Unstable; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Corona

2000
The effect of aspirin on C-reactive protein as a marker of risk in unstable angina.
    Journal of the American College of Cardiology, 2001, Volume: 37, Issue:5

    Topics: Aged; Angina, Unstable; Aspirin; Biomarkers; C-Reactive Protein; Cohort Studies; Female; Follow-Up S

2001
Platelet aggregability under shear is enhanced in patients with unstable angina pectoris who developed acute myocardial infarction.
    Japanese circulation journal, 2001, Volume: 65, Issue:4

    Topics: Aged; Angina, Unstable; Anticoagulants; Aspirin; Biomarkers; Comorbidity; Coronary Thrombosis; Creat

2001
A study of the use of aspirin by general practitioners in suspected myocardial infarction.
    Irish medical journal, 2001, Volume: 94, Issue:2

    Topics: Adult; Aged; Angina, Unstable; Aspirin; Chest Pain; Data Collection; Drug Utilization; Family Practi

2001
[Optimal platelet inhibition therapy in unstable angina pectoris and after coronary interventions].
    Herz, 2001, Volume: 26 Suppl 1

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clinical Trials as Topic;

2001
Clinical application of procedural platelet monitoring during percutaneous coronary intervention among patients at increased bleeding risk.
    Journal of thrombosis and thrombolysis, 2001, Volume: 11, Issue:2

    Topics: Abciximab; Adult; Aged; Aged, 80 and over; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibod

2001
[Which medical treatment can minimize late complications after pharmacologic treatment of unstable angina?].
    Polskie Archiwum Medycyny Wewnetrznej, 2000, Volume: 104, Issue:6

    Topics: Adrenergic beta-Antagonists; Ambulatory Care; Angina, Unstable; Angiotensin-Converting Enzyme Inhibi

2000
Quality of care among elderly patients hospitalized with unstable angina.
    American heart journal, 2001, Volume: 142, Issue:2

    Topics: Aged; Aged, 80 and over; Angina, Unstable; Anticoagulants; Aspirin; Connecticut; Electrocardiography

2001
Clopidogrel in invasive management of non-ST-elevation ACS.
    Lancet (London, England), 2001, Aug-18, Volume: 358, Issue:9281

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Humans; My

2001
[Antithrombotic therapy of unstable angina pectoris].
    Duodecim; laaketieteellinen aikakauskirja, 1998, Volume: 114, Issue:15

    Topics: Angina, Unstable; Aspirin; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Humans; Myocardi

1998
[Clopidogrel in acute coronary syndromes with non-ST elevation. Clinical implications of the CURE trial].
    Revista espanola de cardiologia, 2001, Volume: 54, Issue:10

    Topics: Angina, Unstable; Aspirin; Clopidogrel; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Hu

2001
Bivalirudin versus heparin during coronary angioplasty for unstable or postinfarction angina: Final report reanalysis of the Bivalirudin Angioplasty Study.
    American heart journal, 2001, Volume: 142, Issue:6

    Topics: Actuarial Analysis; Adult; Aged; Aged, 80 and over; Angina Pectoris; Angina, Unstable; Angioplasty,

2001
Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes.
    The New England journal of medicine, 2001, Nov-22, Volume: 345, Issue:21

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Combined Modality Therapy; Fibrinolytic A

2001
Guideline-compliant care improves one-year outcomes in patients with unstable angina.
    Report on medical guidelines & outcomes research, 2000, Aug-03, Volume: 11, Issue:16

    Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Aspirin; Coronary Artery Bypass; Heart Failure;

2000
Influence of patient characteristics and renal function on factor Xa inhibition pharmacokinetics and pharmacodynamics after enoxaparin administration in non-ST-segment elevation acute coronary syndromes.
    American heart journal, 2002, Volume: 143, Issue:5

    Topics: Age Factors; Aged; Angina, Unstable; Area Under Curve; Aspirin; Biomarkers; Body Weight; Coronary Ar

2002
Early statin initiation and outcomes in patients with acute coronary syndromes.
    JAMA, 2002, Jun-19, Volume: 287, Issue:23

    Topics: Acute Disease; Aged; Angina, Unstable; Aspirin; Female; Humans; Hydroxymethylglutaryl-CoA Reductase

2002
[Development of myocardial infarction in aspirin-treated unstable angina pectoris. Repeated studies of platelet aggregation and of the thromboxane-prostacyclin system].
    Kardiologiia, 1992, Volume: 32, Issue:9-10

    Topics: Adult; Angina, Unstable; Aspirin; Epoprostenol; Humans; Male; Middle Aged; Myocardial Infarction; Pl

1992
Predischarge exercise echocardiography in patients with unstable angina who respond to medical treatment.
    Clinical cardiology, 1992, Volume: 15, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina, Unstable; Aspirin; Calcium Channel Blockers; Cardi

1992
Effect of maximal medical therapy on refractoriness of unstable angina pectoris.
    The American journal of cardiology, 1992, Sep-01, Volume: 70, Issue:6

    Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Calciu

1992
Is thrombolytic therapy striking out in unstable angina?
    Circulation, 1992, Volume: 86, Issue:5

    Topics: Angina, Unstable; Aspirin; Heparin; Humans; Myocardial Infarction; Thrombolytic Therapy; Urokinase-T

1992
Thrombosis in unstable angina.
    The New England journal of medicine, 1992, Jul-16, Volume: 327, Issue:3

    Topics: Angina, Unstable; Aspirin; Coronary Thrombosis; Heparin; Humans; Myocardial Infarction; Prognosis; T

1992
Low-dose aspirin and heparin in unstable coronary artery disease.
    Lancet (London, England), 1991, Feb-23, Volume: 337, Issue:8739

    Topics: Angina, Unstable; Aspirin; Heparin; Humans; Time Factors

1991
[Heparin therapy in coronary disease].
    Deutsche medizinische Wochenschrift (1946), 1992, Jan-03, Volume: 117, Issue:1

    Topics: Angina, Unstable; Aspirin; Coronary Disease; Drug Therapy, Combination; Heparin; Humans; Myocardial

1992
Use of acetylsalicylic acid by physicians and in the community.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1991, Nov-01, Volume: 145, Issue:9

    Topics: Adolescent; Adult; Aged; Angina, Unstable; Aspirin; Cardiovascular Diseases; Community Medicine; Dru

1991
Clinical and angiographic characteristics and outcome of patients with rest-unstable angina occurring during regular aspirin use.
    Journal of the American College of Cardiology, 1991, Nov-15, Volume: 18, Issue:6

    Topics: Adult; Aged; Angina, Unstable; Aspirin; Chi-Square Distribution; Coronary Angiography; Female; Follo

1991
Coronary angioplasty for medically refractory unstable angina in patients with prior coronary bypass surgery.
    Catheterization and cardiovascular diagnosis, 1990, Volume: 20, Issue:3

    Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary

1990
[Treatment of unstable angina pectoris. A questionnaire study].
    Ugeskrift for laeger, 1990, Aug-13, Volume: 152, Issue:33

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Aspirin; Calcium Channel Blockers; Denmark; Drug Util

1990
[Drug therapy of unstable angina].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1990, Nov-10, Volume: 79, Issue:11

    Topics: Adrenergic beta-Antagonists; Angina, Unstable; Aspirin; Calcium Channel Blockers; Drug Therapy, Comb

1990
Therapeutic interventions which may improve survival in patients with coronary artery disease.
    Acta cardiologica, 1990, Volume: 45, Issue:6

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Aspirin; Coronary Artery Bypass; Cor

1990
[Adhesive activity of blood platelets in patients with stable or unstable angina pectoris and acute myocardial infarct].
    Kardiologiia, 1991, Volume: 31, Issue:2

    Topics: Adult; Aged; Angina Pectoris; Angina, Unstable; Aspirin; Creatine Kinase; Humans; Male; Microscopy,

1991
Detection of silent myocardial ischemia in asymptomatic selected population and in unstable angina.
    Advances in cardiology, 1990, Volume: 37

    Topics: Adult; Aged; Angina, Unstable; Aspirin; Coronary Disease; Electrocardiography, Ambulatory; Exercise

1990
Product licences and devious promotion.
    Drug and therapeutics bulletin, 1990, Mar-05, Volume: 28, Issue:5

    Topics: Advertising; Angina, Unstable; Aspirin; Drug Industry; Myocardial Infarction; United Kingdom

1990
[Aspirin in the prevention and management of coronary artery disease].
    Boletin de la Asociacion Medica de Puerto Rico, 1990, Volume: 82, Issue:6

    Topics: Angina, Unstable; Aspirin; Coronary Disease; Humans; Myocardial Infarction

1990
Differences in bleeding time, aspirin sensitivity and adrenaline between acute myocardial infarction and unstable angina.
    Cardiovascular research, 1990, Volume: 24, Issue:1

    Topics: Aged; Angina Pectoris; Angina, Unstable; Aspirin; Bleeding Time; Blood Platelets; Chest Pain; Epinep

1990
[Unstable stenocardia: various problems of pathogenesis and treatment].
    Kardiologiia, 1989, Volume: 29, Issue:10

    Topics: Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Constriction, Pathologic

1989
Aspirin, heparin, or both to treat unstable angina.
    The New England journal of medicine, 1989, Apr-13, Volume: 320, Issue:15

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Heparin; Humans; Myocardial Infarction

1989
Unstable angina revisited once more.
    European heart journal, 1986, Volume: 7, Issue:12

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon; Aspirin; Combi

1986
Management of patients after myocardial infarction.
    Hospital practice (Office ed.), 1987, Apr-15, Volume: 22, Issue:4

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Anticoagulants; Aspirin; Cardiac Cat

1987
Use of percutaneous transluminal coronary angioplasty and bypass surgery despite improved medical therapy for unstable angina pectoris.
    The American journal of cardiology, 1988, May-09, Volume: 61, Issue:14

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon; Aspirin; Calci

1988
Coronary angioplasty in refractory unstable angina.
    The New England journal of medicine, 1986, Jan-30, Volume: 314, Issue:5

    Topics: Angina Pectoris; Angina, Unstable; Angioplasty, Balloon; Aspirin; Coronary Vessels; Humans

1986
Aspirin for unstable angina?
    British medical journal (Clinical research ed.), 1986, Jul-05, Volume: 293, Issue:6538

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Humans; Myocardial Infarction; Platelet Aggregation; Pro

1986
Altered intraplatelet arachidonic acid metabolism during the acute state of unstable angina.
    Thrombosis research, 1987, Apr-15, Volume: 46, Issue:2

    Topics: Acute Disease; Angina Pectoris; Angina, Unstable; Arachidonic Acid; Arachidonic Acids; Aspirin; Bloo

1987
Secondary prevention of vascular disease by prolonged antiplatelet treatment. Antiplatelet Trialists' Collaboration.
    British medical journal (Clinical research ed.), 1988, Jan-30, Volume: 296, Issue:6618

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Cerebrovascular Disorders; Dipyridamole; Drug Combinatio

1988
[Effect of various drugs on rheological properties of the blood and hemostasis in patients with unstable stenocardia].
    Klinicheskaia meditsina, 1987, Volume: 65, Issue:4

    Topics: Adult; Aged; Angina Pectoris; Angina, Unstable; Aspirin; Blood Viscosity; Female; Hemostasis; Humans

1987
Dissolution of angiographically detected intracoronary thrombus for unstable angina pectoris after aspirin therapy.
    The American journal of cardiology, 1987, Sep-15, Volume: 60, Issue:8

    Topics: Aged; Angina Pectoris; Angina, Unstable; Angiography; Aspirin; Coronary Disease; Coronary Thrombosis

1987
Speculation regarding mechanisms responsible for acute ischemic heart disease syndromes.
    Journal of the American College of Cardiology, 1986, Volume: 8, Issue:1

    Topics: Angina, Unstable; Animals; Aspirin; Coronary Circulation; Coronary Disease; Coronary Vasospasm; Dogs

1986
[Effect of hemosorption and the separate and combined use of obsidan, trental and colpharit on rheological and hemostatic properties of the blood in patients with unstable stenocardia].
    Terapevticheskii arkhiv, 1986, Volume: 58, Issue:5

    Topics: Adult; Aged; Angina Pectoris; Angina, Unstable; Aspirin; Blood Viscosity; Combined Modality Therapy;

1986