aspirin has been researched along with American Trypanosomiasis in 16 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The consequences of using aspirin (ASA) for the pathogenesis of Chagas disease are unclear." | 7.85 | Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease. ( Araújo, EJ; Massocatto, CL; Moreira, NM; Muniz, E; Pinge-Filho, P; Rossi, RM; Sant'Ana, DM, 2017) |
| " cruzi infection (Brazil strain) beginning 5 days post infection (dpi) with aspirin (ASA) increased mortality (2-fold) and parasitemia (12-fold)." | 7.77 | Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease. ( Ashton, AW; Collado, JE; Factor, SM; Fine, EJ; Huang, H; Jelicks, LA; Koba, W; Machado, FS; Mukherjee, S; Oz, HS; Prado, CM; Tanowitz, HB; Weiss, LM; Zhao, D, 2011) |
| "Thus treatment with aspirin in the chronic phase of Chagas' disease changes the natural history of the disease and raises the possibility of using it as a new therapeutic approach to the treatment of this aspect of Chagas' disease pathology." | 5.46 | Treatment with low doses of aspirin during chronic phase of experimental Chagas' disease increases oesophageal nitrergic neuronal subpopulation in mice. ( de Almeida Araújo, EJ; de Mello Gonçales Sant'ana, D; Marques de Araújo, S; Martins Moreira, N; Massocatto, CL; Muniz, E; Pinge-Filho, P; Rossi, RM, 2017) |
| "The consequences of using aspirin (ASA) for the pathogenesis of Chagas disease are unclear." | 3.85 | Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease. ( Araújo, EJ; Massocatto, CL; Moreira, NM; Muniz, E; Pinge-Filho, P; Rossi, RM; Sant'Ana, DM, 2017) |
| " cruzi infection (Brazil strain) beginning 5 days post infection (dpi) with aspirin (ASA) increased mortality (2-fold) and parasitemia (12-fold)." | 3.77 | Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease. ( Ashton, AW; Collado, JE; Factor, SM; Fine, EJ; Huang, H; Jelicks, LA; Koba, W; Machado, FS; Mukherjee, S; Oz, HS; Prado, CM; Tanowitz, HB; Weiss, LM; Zhao, D, 2011) |
| "Chagas disease is a vector-borne disease caused by the protozoan parasite Trypanosoma cruzi." | 1.56 | Notch receptor expression in Trypanosoma cruzi-infected human umbilical vein endothelial cells treated with benznidazole or simvastatin revealed by microarray analysis. ( Campos-Estrada, C; Carillo, I; Castillo, C; González-Herrera, F; Greif, G; Guzmán-Rivera, D; Kemmerling, U; Liempi, A; Maya, JD; Robello, C, 2020) |
| "Chagas disease is a potentially fatal disease caused by the parasite Trypanosoma cruzi, which can in some cases affect the central nervous system." | 1.48 | Protective effect of aspirin treatment on mouse behavior in the acute phase of experimental infection with Trypanosoma cruzi. ( Acosta, N; Centurión-Wenninger, C; Figueredo-Thiel, S; Meza-Ojeda, A; Mongelós-Cardozo, M; Morínigo-Guayuán, S; Sanchez, DF; Silvero-Isidre, A, 2018) |
| "Aspirin treatment during the acute phase of infection reduced parasitemia (P<." | 1.46 | Myenteric neuroprotective role of aspirin in acute and chronic experimental infections with Trypanosoma cruzi. ( Araújo, EJA; Araújo, SM; Belém, MO; Buttow, NC; Carlos, TM; Gouveia, R; Luchetti, BFC; Massocatto, CL; Moreira, NM; Oda, JY; Pinge-Filho, P; Sant Ana, DMG, 2017) |
| "Thus treatment with aspirin in the chronic phase of Chagas' disease changes the natural history of the disease and raises the possibility of using it as a new therapeutic approach to the treatment of this aspect of Chagas' disease pathology." | 1.46 | Treatment with low doses of aspirin during chronic phase of experimental Chagas' disease increases oesophageal nitrergic neuronal subpopulation in mice. ( de Almeida Araújo, EJ; de Mello Gonçales Sant'ana, D; Marques de Araújo, S; Martins Moreira, N; Massocatto, CL; Muniz, E; Pinge-Filho, P; Rossi, RM, 2017) |
| "Gastritis is a common ailment that can be caused by poor dietary habits, intake of alcohol or other gastric irritants, bacterial infection, or by the widespread use of non-steroidal anti-inflammatory drugs (NSAIDs)." | 1.43 | Aspirin treatment exacerbates oral infections by Trypanosoma cruzi. ( Cossentini, LA; Da Silva, RV; De Almeida Araújo, EJ; Pinge-Filho, P; Yamada-Ogatta, SF; Yamauchi, LM, 2016) |
| "PGE2 involvement in experimental Trypanosoma cruzi infection depends on the lethal capacity of the parasite subpopulation used." | 1.29 | PGE2 involvement in experimental infection with Trypanosoma cruzi subpopulations. ( Borda, E; Celentano, AM; González Cappa, SM; Gorelik, G; Solana, ME; Sterin-Borda, L, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 5 (31.25) | 2.80 |
| Authors | Studies |
|---|---|
| Pavão, RB | 1 |
| Moreira, HT | 1 |
| Pintya, AO | 1 |
| Haddad, JL | 1 |
| Badran, AV | 1 |
| Lima-Filho, MO | 1 |
| Lago, IM | 1 |
| Chierice, JRA | 1 |
| Schmidt, A | 1 |
| Marin-Neto, JA | 1 |
| do Carmo Neto, JR | 1 |
| Guerra, RO | 1 |
| Rodrigues, WF | 1 |
| da Silva, MV | 1 |
| Machado, JR | 1 |
| Dos Santos, LF | 1 |
| Rodrigues, GF | 1 |
| Malvezi, AD | 2 |
| de Souza, M | 1 |
| Nakama, RP | 1 |
| Lovo-Martins, MI | 2 |
| Pinge-Filho, P | 6 |
| Campos-Estrada, C | 2 |
| González-Herrera, F | 1 |
| Greif, G | 1 |
| Carillo, I | 1 |
| Guzmán-Rivera, D | 1 |
| Liempi, A | 1 |
| Robello, C | 1 |
| Kemmerling, U | 2 |
| Castillo, C | 2 |
| Maya, JD | 2 |
| Pereira, RS | 1 |
| Lucchetti, BFC | 1 |
| Santos, JP | 1 |
| Tavares, ER | 1 |
| Verri, WA | 1 |
| de Almeida Araújo, EJ | 3 |
| Yamauchi, LM | 2 |
| Yamada-Ogatta, SF | 2 |
| Martins-Pinge, MC | 1 |
| Oda, JY | 1 |
| Belém, MO | 1 |
| Carlos, TM | 1 |
| Gouveia, R | 1 |
| Luchetti, BFC | 1 |
| Moreira, NM | 3 |
| Massocatto, CL | 4 |
| Araújo, SM | 2 |
| Sant Ana, DMG | 1 |
| Buttow, NC | 1 |
| Araújo, EJA | 2 |
| Silvero-Isidre, A | 1 |
| Morínigo-Guayuán, S | 1 |
| Meza-Ojeda, A | 1 |
| Mongelós-Cardozo, M | 1 |
| Centurión-Wenninger, C | 1 |
| Figueredo-Thiel, S | 1 |
| Sanchez, DF | 1 |
| Acosta, N | 1 |
| Martins Moreira, N | 1 |
| Muniz, E | 2 |
| Marques de Araújo, S | 1 |
| Rossi, RM | 2 |
| de Mello Gonçales Sant'ana, D | 1 |
| Souza, ND | 1 |
| Belin, BS | 1 |
| Sant'ana, DMG | 1 |
| P Filho, P | 1 |
| Nihei, OK | 1 |
| Molina-Berríos, A | 1 |
| Henriquez, N | 1 |
| Faúndez, M | 1 |
| Torres, G | 1 |
| Escanilla, S | 1 |
| Morello, A | 1 |
| López-Muñoz, RA | 1 |
| Araújo, EJ | 1 |
| Sant'Ana, DM | 1 |
| Cossentini, LA | 1 |
| Da Silva, RV | 1 |
| Mukherjee, S | 1 |
| Machado, FS | 1 |
| Huang, H | 1 |
| Oz, HS | 1 |
| Jelicks, LA | 1 |
| Prado, CM | 1 |
| Koba, W | 1 |
| Fine, EJ | 1 |
| Zhao, D | 1 |
| Factor, SM | 1 |
| Collado, JE | 1 |
| Weiss, LM | 1 |
| Tanowitz, HB | 1 |
| Ashton, AW | 1 |
| Paiva, CN | 1 |
| Arras, RH | 1 |
| Lessa, LP | 1 |
| Gibaldi, D | 1 |
| Alves, L | 1 |
| Metz, CN | 1 |
| Gazzinelli, R | 1 |
| Pyrrho, AS | 1 |
| Lannes-Vieira, J | 1 |
| Bozza, MT | 1 |
| de Bracco, MM | 1 |
| Sterin-Borda, L | 2 |
| Fink, S | 1 |
| Finiasz, M | 1 |
| Borda, E | 2 |
| Celentano, AM | 1 |
| Gorelik, G | 1 |
| Solana, ME | 1 |
| González Cappa, SM | 1 |
1 review available for aspirin and American Trypanosomiasis
| Article | Year |
|---|---|
Neuroprotective Treatments for Digestive Forms of Chagas Disease in Experimental Models: A Systematic Review.
Topics: Animals; Aspirin; Chagas Disease; Cyclophosphamide; Humans; Mice; Neuroprotective Agents; Trypanosom | 2022 |
1 trial available for aspirin and American Trypanosomiasis
| Article | Year |
|---|---|
Aspirin plus verapamil relieves angina and perfusion abnormalities in patients with coronary microvascular dysfunction and Chagas disease: a pilot non-randomized study.
Topics: Angina Pectoris; Aspirin; Chagas Disease; Female; Humans; Male; Middle Aged; Perfusion; Quality of L | 2021 |
14 other studies available for aspirin and American Trypanosomiasis
| Article | Year |
|---|---|
Beneficial effects of acetylsalicylic acid (aspirin) on the actions of extracellular vesicles shed by Trypanosoma cruzi in macrophages.
Topics: Aspirin; Chagas Disease; Cyclooxygenase 2; Extracellular Vesicles; Humans; Macrophages; Nitric Oxide | 2023 |
Notch receptor expression in Trypanosoma cruzi-infected human umbilical vein endothelial cells treated with benznidazole or simvastatin revealed by microarray analysis.
Topics: Aspirin; Cells, Cultured; Chagas Disease; Gene Expression; HMGB1 Protein; Human Umbilical Vein Endot | 2020 |
Combination Therapy Using Benznidazole and Aspirin during the Acute Phase of Experimental Chagas Disease Prevents Cardiovascular Dysfunction and Decreases Typical Cardiac Lesions in the Chronic Phase.
Topics: Animals; Aspirin; Chagas Disease; Drug Combinations; Humans; Mice; Nitroimidazoles; Trypanocidal Age | 2020 |
Myenteric neuroprotective role of aspirin in acute and chronic experimental infections with Trypanosoma cruzi.
Topics: Animals; Aspirin; Chagas Disease; Cyclooxygenase Inhibitors; Disease Models, Animal; Male; Mice; Mye | 2017 |
Protective effect of aspirin treatment on mouse behavior in the acute phase of experimental infection with Trypanosoma cruzi.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Behavior, Animal; Chagas Disease; Male; M | 2018 |
Treatment with low doses of aspirin during chronic phase of experimental Chagas' disease increases oesophageal nitrergic neuronal subpopulation in mice.
Topics: Animals; Aspirin; Chagas Disease; Chronic Disease; Colon; Disease Models, Animal; Esophagus; Male; M | 2017 |
Effect of acetylsalicylic acid on total myenteric neurons in mice experimentally infected with Trypanosoma cruzi.
Topics: Animals; Aspirin; Chagas Disease; Chronic Disease; Disease Models, Animal; Male; Mice; Myenteric Ple | 2019 |
Protective role of acetylsalicylic acid in experimental Trypanosoma cruzi infection: evidence of a 15-epi-lipoxin A₄-mediated effect.
Topics: Animals; Aspirin; Cell Line; Chagas Disease; Disease Models, Animal; Lipoxins; Male; Mice; Mice, Inb | 2013 |
Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease.
Topics: Animals; Aspirin; Atrophy; Chagas Disease; Chronic Disease; Cyclooxygenase Inhibitors; Disease Model | 2017 |
Aspirin treatment exacerbates oral infections by Trypanosoma cruzi.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Beverages; Chagas Disease; Dietary Carboh | 2016 |
Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chagas Disease; Chronic Disease; Cyclooxy | 2011 |
Unraveling the lethal synergism between Trypanosoma cruzi infection and LPS: a role for increased macrophage reactivity.
Topics: Animals; Aspirin; Chagas Disease; Cyclooxygenase Inhibitors; Endotoxemia; Enzyme-Linked Immunosorben | 2007 |
Stimulatory effect of lymphocytes from Chagas' patients on spontaneously beating rat atria.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aspirin; Catechols; Chagas Cardiomyopathy; Chagas Disease; | 1984 |
PGE2 involvement in experimental infection with Trypanosoma cruzi subpopulations.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Aspirin; Cell Adhesion; Chagas Disease; Dinoprostone; Indom | 1995 |